BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (262 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q18865 Putative uncharacterized protein n=6 Tax=Caenorh...   529   e-149
UniRef50_A8XAK9 Putative uncharacterized protein n=1 Tax=Caenorh...   311   1e-83
UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorh...   303   5e-81
UniRef50_Q18684 Protein T13H10.1, confirmed by transcript eviden...   244   2e-63
UniRef50_Q20933 Putative uncharacterized protein n=1 Tax=Caenorh...   231   2e-59
UniRef50_A8WMP8 Putative uncharacterized protein n=1 Tax=Caenorh...   220   3e-56
UniRef50_P34265 Probable tyrosine-protein kinase kin-31 n=4 Tax=...   205   1e-51
UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax...   197   3e-49
UniRef50_A8NEQ9 Protein kinase domain containing protein (Fragme...   191   2e-47
UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax...   184   2e-45
UniRef50_Q9N4T6 Putative uncharacterized protein n=1 Tax=Caenorh...   180   5e-44
UniRef50_O17755 Protein F01D4.3, partially confirmed by transcri...   172   1e-41
UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia mal...   171   2e-41
UniRef50_Q9TYX4 Putative uncharacterized protein R11E3.1 n=3 Tax...   170   3e-41
UniRef50_A8PJL3 Protein kinase domain containing protein n=1 Tax...   170   4e-41
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...   167   2e-40
UniRef50_Q22765 Protein T25B9.4, partially confirmed by transcri...   159   7e-38
UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, part...   159   8e-38
UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateri...   158   2e-37
UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA    157   3e-37
UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=...   157   3e-37
UniRef50_A8Q767 Protein kinase domain containing protein n=1 Tax...   156   5e-37
UniRef50_A8PMN8 Protein kinase domain containing protein n=1 Tax...   156   6e-37
UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria...   155   1e-36
UniRef50_Q23554 Putative uncharacterized protein n=1 Tax=Caenorh...   152   9e-36
UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1...   152   1e-35
UniRef50_Q9XXE5 Protein Y43C5B.2, partially confirmed by transcr...   151   3e-35
UniRef50_UPI000186DA97 tyrosine-protein kinase transforming prot...   149   1e-34
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...   147   2e-34
UniRef50_Q4S351 Chromosome 4 SCAF14752, whole genome shotgun seq...   147   4e-34
UniRef50_O44570 Putative uncharacterized protein n=1 Tax=Caenorh...   146   6e-34
UniRef50_A8QBK0 Protein kinase domain containing protein n=1 Tax...   144   4e-33
UniRef50_P91360 Putative uncharacterized protein n=3 Tax=root Re...   142   1e-32
UniRef50_O01798 Defective spermatogenesis protein 8 n=3 Tax=Caen...   141   2e-32
UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidenc...   140   5e-32
UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia ...   137   3e-31
UniRef50_A8XL41 Putative uncharacterized protein n=2 Tax=Caenorh...   136   6e-31
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...   135   2e-30
UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes relate...   134   4e-30
UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephyd...   133   6e-30
UniRef50_A8QEG4 Protein kinase domain containing protein n=1 Tax...   132   1e-29
UniRef50_A8XFQ1 Putative uncharacterized protein n=2 Tax=Caenorh...   131   2e-29
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   131   2e-29
UniRef50_A8Q7I8 Protein kinase domain containing protein n=1 Tax...   131   3e-29
UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76...   131   3e-29
UniRef50_Q19726 Protein F22D6.1, partially confirmed by transcri...   130   6e-29
UniRef50_Q7YSY1 Fes-like tyrosine kinase protein n=5 Tax=Schisto...   128   2e-28
UniRef50_Q8I4A8 Protein ZK20.2, partially confirmed by transcrip...   128   2e-28
UniRef50_Q21764 Protein R05H5.4, partially confirmed by transcri...   127   3e-28
UniRef50_A8P3F9 Protein kinase domain containing protein n=1 Tax...   121   3e-26
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...   120   3e-26
UniRef50_Q23102 Protein W01B6.5, partially confirmed by transcri...   119   1e-25
UniRef50_A8WPD7 Putative uncharacterized protein n=4 Tax=Caenorh...   118   2e-25
UniRef50_A8XI09 Putative uncharacterized protein n=1 Tax=Caenorh...   117   4e-25
UniRef50_Q21292 Protein K07F5.4a, partially confirmed by transcr...   117   5e-25
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   116   9e-25
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...   115   1e-24
UniRef50_Q9U2T8 Protein Y116A8C.38, partially confirmed by trans...   114   3e-24
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   112   1e-23
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...   112   1e-23
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...   111   2e-23
UniRef50_C4Q4A1 Term=tyrosine kinase 5;db_xref=PMID:11289068;wit...   111   2e-23
UniRef50_A8XXS8 Putative uncharacterized protein n=2 Tax=Caenorh...   110   4e-23
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   110   4e-23
UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californic...   110   4e-23
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   110   6e-23
UniRef50_B3XVX8 Protein tyrosine kinase fes/fps n=1 Tax=Codonosi...   110   7e-23
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   110   7e-23
UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepI...   109   7e-23
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...   109   8e-23
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          109   1e-22
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          108   1e-22
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   108   1e-22
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   108   2e-22
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   108   2e-22
UniRef50_Q19704 Protein F22B3.8, partially confirmed by transcri...   107   4e-22
UniRef50_A8WVF6 Putative uncharacterized protein n=2 Tax=root Re...   107   5e-22
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   107   6e-22
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   107   6e-22
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   106   7e-22
UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative ...   106   1e-21
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE     105   1e-21
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   105   1e-21
UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein ...   105   2e-21
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   105   2e-21
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   105   2e-21
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...   103   4e-21
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...   103   4e-21
UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosi...   103   8e-21
UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni ...   102   9e-21
UniRef50_Q9XW34 Protein Y69E1A.3, partially confirmed by transcr...   102   1e-20
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   100   5e-20
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...   100   8e-20
UniRef50_A8WSQ7 Putative uncharacterized protein n=2 Tax=Caenorh...   100   9e-20
UniRef50_A8PFG2 Protein kinase domain containing protein n=1 Tax...    99   1e-19
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...    99   2e-19
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...    99   2e-19
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...    98   3e-19
UniRef50_C4XV88 Venus kinase receptor (Fragment) n=3 Tax=Coeloma...    98   3e-19
UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax...    97   5e-19
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...    96   8e-19
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...    96   8e-19
UniRef50_Q9U3B5 Protein K09B11.5a, confirmed by transcript evide...    96   8e-19
UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun se...    95   2e-18
UniRef50_C5H7R9 Venus kinase receptor (Fragment) n=2 Tax=Triboli...    95   3e-18
UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine ki...    95   3e-18
UniRef50_Q25197 Putative insulin-like peptide receptor n=3 Tax=E...    93   8e-18
UniRef50_UPI000186EE87 tyrosine kinase receptor, putative n=4 Ta...    93   8e-18
UniRef50_UPI00017915D5 PREDICTED: similar to tyrosine-protein ki...    93   1e-17
UniRef50_UPI0001792C07 PREDICTED: similar to tyrosine-protein ki...    92   1e-17
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...    92   2e-17
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...    92   2e-17
UniRef50_C4XV92 Venus kinase receptor (Fragment) n=6 Tax=Drosoph...    91   3e-17
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...    91   4e-17
UniRef50_Q17JW1 Tyrosine protein kinase n=2 Tax=Culicini RepID=Q...    91   5e-17
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...    91   5e-17
UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Su...    91   6e-17
UniRef50_A8NM59 Protein kinase domain containing protein n=1 Tax...    90   6e-17
UniRef50_Q52V39 Tyrosine-protein kinase receptor n=3 Tax=Branchi...    90   6e-17
UniRef50_C5H7S1 Venus kinase receptor n=3 Tax=Culicidae RepID=C5...    90   7e-17
UniRef50_B7QM19 Tyrosine-protein kinase receptor n=2 Tax=Ixodes ...    90   7e-17
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...    90   8e-17
UniRef50_P08922 Proto-oncogene tyrosine-protein kinase ROS n=24 ...    90   8e-17
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...    90   9e-17
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...    90   9e-17
UniRef50_A8XS61 Putative uncharacterized protein n=2 Tax=Caenorh...    89   1e-16
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...    89   1e-16
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...    89   1e-16
UniRef50_Q5MCM8 Protein-tyrosine kinase (Fragment) n=4 Tax=Antho...    89   1e-16
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...    89   1e-16
UniRef50_UPI0001791F4A PREDICTED: similar to AGAP011648-PA n=1 T...    89   2e-16
UniRef50_C4XV89 Venus kinase receptor (Fragment) n=2 Tax=Pedicul...    89   2e-16
UniRef50_UPI00004D86FC Tyrosine-protein kinase Tec (EC 2.7.10.2)...    89   2e-16
UniRef50_UPI00004D7E5F Proto-oncogene tyrosine-protein kinase ME...    88   2e-16
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...    88   2e-16
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...    88   2e-16
UniRef50_P34152 Focal adhesion kinase 1 n=16 Tax=Eutheria RepID=...    88   3e-16
UniRef50_B7P3J2 Leukocyte tyrosine kinase receptor, putative n=1...    88   4e-16
UniRef50_UPI0000DB6DD4 PREDICTED: similar to Insulin-like growth...    87   4e-16
UniRef50_P00529 Tyrosine-protein kinase transforming protein ros...    87   4e-16
UniRef50_P06213 Insulin receptor subunit beta n=70 Tax=Euteleost...    87   4e-16
UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona inte...    87   5e-16
UniRef50_Q25410 Putative molluscan insulin-related peptide(s) re...    87   5e-16
UniRef50_B3XVX1 Protein tyrosine kinase syk (Fragment) n=1 Tax=M...    87   6e-16
UniRef50_Q05397 Focal adhesion kinase 1 n=105 Tax=cellular organ...    87   7e-16
UniRef50_Q9VBW3 Tyrosine kinase receptor Cad96Ca n=14 Tax=Coelom...    87   7e-16
UniRef50_B3RWF6 Putative uncharacterized protein (Fragment) n=1 ...    87   7e-16
UniRef50_P14616 Insulin receptor-related protein beta chain n=11...    87   7e-16
UniRef50_UPI0000DB7426 PREDICTED: similar to insulin-like growth...    87   7e-16
UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera...    87   8e-16
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...    87   8e-16
UniRef50_Q2LC18 Tyrosine-protein kinase receptor (Fragment) n=2 ...    87   8e-16
UniRef50_Q5C5Y5 SJCHGC03615 protein (Fragment) n=1 Tax=Schistoso...    87   8e-16
UniRef50_Q4RM64 Chromosome 10 SCAF15019, whole genome shotgun se...    86   1e-15
UniRef50_UPI0000EC9DFD Insulin receptor related tyrosine kinase ...    86   1e-15
UniRef50_UPI000194BA20 PREDICTED: EPH receptor A3 n=2 Tax=Eutele...    86   1e-15
UniRef50_B7QAX3 Tyrosine-protein kinase receptor n=1 Tax=Ixodes ...    86   1e-15
UniRef50_P08069 Insulin-like growth factor 1 receptor beta chain...    86   1e-15
UniRef50_UPI000155484B PREDICTED: similar to type 1 IGF receptor...    86   1e-15
UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes...    85   2e-15
UniRef50_Q9GRH1 Tyrosine-protein kinase receptor n=4 Tax=Porifer...    85   2e-15
UniRef50_Q7Q0F6 Tyrosine-protein kinase receptor n=1 Tax=Anophel...    85   2e-15
UniRef50_UPI0001757DA5 PREDICTED: similar to insulin receptor, p...    85   2e-15
UniRef50_UPI0001927441 PREDICTED: similar to cDNA sequence BC021...    85   2e-15
UniRef50_A9V908 Predicted protein n=1 Tax=Monosiga brevicollis R...    85   2e-15
UniRef50_Q4RVA1 Chromosome 15 SCAF14992, whole genome shotgun se...    85   3e-15
UniRef50_B4JP34 GH13860 n=4 Tax=Diptera RepID=B4JP34_DROGR             85   3e-15
UniRef50_Q4SP88 Ephrin receptor (Fragment) n=4 Tax=Euteleostomi ...    85   3e-15
UniRef50_Q21299 Protein W08D2.8, partially confirmed by transcri...    85   3e-15
UniRef50_C5H7S0 Venus kinase receptor (Fragment) n=2 Tax=Apis me...    84   3e-15
UniRef50_Q4T272 Chromosome undetermined SCAF10323, whole genome ...    84   4e-15
UniRef50_Q9U5A8 Tyrosine-protein kinase receptor n=4 Tax=Coeloma...    84   4e-15
UniRef50_UPI0000ECD739 Cytoplasmic tyrosine-protein kinase BMX (...    84   4e-15
UniRef50_B7Q0S4 Tyrosine-protein kinase receptor n=1 Tax=Ixodes ...    84   5e-15
UniRef50_B4JPQ9 GH13351 n=3 Tax=Drosophila RepID=B4JPQ9_DROGR          84   5e-15
UniRef50_A8XT57 Putative uncharacterized protein n=1 Tax=Caenorh...    84   5e-15
UniRef50_Q29D86 GA13409 n=5 Tax=Drosophila RepID=Q29D86_DROPS          84   5e-15
UniRef50_Q24488 Tyrosine-protein kinase transmembrane receptor R...    84   6e-15
UniRef50_Q05688 Insulin-like growth factor 1 receptor beta chain...    84   6e-15
UniRef50_UPI000186E0DC Insulin receptor precursor, putative n=2 ...    84   7e-15
UniRef50_B6HTA0 Pc22g17780 protein n=1 Tax=Penicillium chrysogen...    84   7e-15
UniRef50_UPI0000D57178 PREDICTED: similar to Ret oncogene CG1439...    83   8e-15
UniRef50_UPI000194C599 PREDICTED: similar to leukocyte tyrosine ...    83   8e-15
UniRef50_UPI000186EF8B ALK tyrosine kinase receptor precursor, p...    83   9e-15
UniRef50_Q9Y1X8 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...    83   9e-15
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...    83   9e-15
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...    83   1e-14
UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n...    83   1e-14
UniRef50_Q03351 NT-3 growth factor receptor n=21 Tax=Euteleostom...    83   1e-14
UniRef50_Q16288 NT-3 growth factor receptor n=57 Tax=Euteleostom...    83   1e-14
UniRef50_Q98TD0 Ephrin receptor n=6 Tax=Amniota RepID=Q98TD0_CHICK     82   1e-14
UniRef50_C4V8N0 Putative uncharacterized protein n=1 Tax=Nosema ...    82   1e-14
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...    82   2e-14
UniRef50_A3KPS2 Tyrosine-protein kinase receptor (Fragment) n=11...    82   2e-14
UniRef50_Q4SUM3 Ephrin receptor (Fragment) n=5 Tax=Tetraodontida...    82   2e-14
UniRef50_UPI000194BE92 PREDICTED: similar to fusion protein EML4...    82   2e-14
UniRef50_A9UQ73 Predicted protein (Fragment) n=1 Tax=Monosiga br...    82   2e-14
UniRef50_A8NGE1 Protein kinase domain containing protein n=1 Tax...    82   2e-14
UniRef50_Q12866 Tyrosine-protein kinase Mer n=37 Tax=root RepID=...    82   2e-14
UniRef50_C4QEV8 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...    82   2e-14
UniRef50_C4Q2H0 Tyrosine kinase n=2 Tax=Schistosoma mansoni RepI...    82   2e-14
UniRef50_Q7PYY7 AGAP011648-PA (Fragment) n=2 Tax=Culicidae RepID...    82   3e-14
UniRef50_B4LZ52 GJ23294 n=4 Tax=Coelomata RepID=B4LZ52_DROVI           81   3e-14
UniRef50_A2QHV0 Contig An04c0070, complete genome n=2 Tax=Asperg...    81   3e-14
UniRef50_UPI000186EA5D proto-oncogene receptor tyrosine protein ...    81   3e-14
UniRef50_Q7KJ08 Alk n=7 Tax=melanogaster group RepID=Q7KJ08_DROME      81   3e-14
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...    81   3e-14
UniRef50_Q8T2I8 Putative uncharacterized protein sepA n=1 Tax=Di...    81   4e-14
UniRef50_B2W0T3 Serine/threonine-protein kinase 3 n=5 Tax=Leotio...    81   4e-14
UniRef50_Q7PZ80 AGAP011776-PA n=4 Tax=Culicidae RepID=Q7PZ80_ANOGA     81   4e-14
UniRef50_Q9VZI2 Ack n=9 Tax=Drosophila RepID=Q9VZI2_DROME              81   4e-14
UniRef50_Q28WN9 GA20930 n=6 Tax=Drosophila RepID=Q28WN9_DROPS          81   4e-14
UniRef50_B4DSE0 Ephrin receptor n=19 Tax=Euteleostomi RepID=B4DS...    81   4e-14
UniRef50_Q4SK07 Tyrosine-protein kinase receptor (Fragment) n=2 ...    81   4e-14
UniRef50_Q16620 BDNF/NT-3 growth factors receptor n=90 Tax=Eutel...    81   4e-14
UniRef50_P09208 Insulin-like receptor subunit beta 2 n=48 Tax=Co...    81   4e-14
UniRef50_C3XPN4 Putative uncharacterized protein n=1 Tax=Branchi...    81   4e-14
UniRef50_C5DPQ3 ZYRO0A05214p n=1 Tax=Zygosaccharomyces rouxii Re...    81   4e-14
UniRef50_O81809 MAP3K epsilon protein kinase n=9 Tax=Magnoliophy...    81   4e-14
UniRef50_UPI000176070B PREDICTED: v-ros UR2 sarcoma virus oncoge...    80   5e-14
UniRef50_UPI00019252ED PREDICTED: similar to predicted protein n...    80   5e-14
UniRef50_C4QVZ2 Putative uncharacterized protein n=1 Tax=Pichia ...    80   5e-14
UniRef50_Q170Z1 Tyrosine-protein kinase receptor (Fragment) n=1 ...    80   6e-14
UniRef50_A8NSH8 Putative uncharacterized protein n=1 Tax=Coprino...    80   6e-14
UniRef50_C1EGF7 Predicted protein n=1 Tax=Micromonas sp. RCC299 ...    80   6e-14
UniRef50_P29323 Ephrin type-B receptor 2 n=364 Tax=Eumetazoa Rep...    80   7e-14
UniRef50_B0XJJ2 Testis-specific serine/threonine-protein kinase ...    80   7e-14
UniRef50_Q9UM73 ALK tyrosine kinase receptor n=79 Tax=root RepID...    80   8e-14
UniRef50_UPI00017930FA PREDICTED: similar to protein kinase prot...    80   8e-14
UniRef50_Q07912 Activated CDC42 kinase 1 n=46 Tax=Euteleostomi R...    80   8e-14
UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata R...    80   8e-14
UniRef50_B3XVW0 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...    80   8e-14
UniRef50_Q14289 Protein-tyrosine kinase 2-beta n=51 Tax=Euteleos...    80   8e-14
UniRef50_C4M8T8 Protein kinase, putative n=3 Tax=Entamoeba RepID...    80   9e-14
UniRef50_Q9GRH2 Tyrosine-protein kinase receptor n=1 Tax=Sycon r...    80   1e-13
UniRef50_B3RT16 Tyrosine-protein kinase receptor (Fragment) n=1 ...    80   1e-13
UniRef50_O97191 Tyrosine-protein kinase receptor n=1 Tax=Geodia ...    80   1e-13
UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2...    80   1e-13
UniRef50_UPI000186D702 tyrosine-protein kinase pr2, putative n=1...    80   1e-13
UniRef50_A9SD09 Predicted protein n=1 Tax=Physcomitrella patens ...    79   1e-13
UniRef50_C4R9I2 Tyrosine kinase non-receptor n=10 Tax=Euteleosto...    79   1e-13
UniRef50_Q4SQX3 Chromosome 11 SCAF14528, whole genome shotgun se...    79   1e-13
UniRef50_C9DED1 Fibroblast growth factor receptor B n=1 Tax=Sacc...    79   1e-13
UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Tak...    79   1e-13
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...    79   1e-13
UniRef50_A7TJU8 Putative uncharacterized protein n=1 Tax=Vanderw...    79   1e-13
UniRef50_UPI000186D99E conserved hypothetical protein n=1 Tax=Pe...    79   1e-13
UniRef50_UPI000175855D PREDICTED: similar to focal adhesion kina...    79   1e-13
UniRef50_D1I166 Whole genome shotgun sequence of line PN40024, s...    79   1e-13
UniRef50_Q7Z1D3 Focal adhesion kinase n=1 Tax=Lytechinus variega...    79   1e-13

>UniRef50_Q18865 Putative uncharacterized protein n=6 Tax=Caenorhabditis
           RepID=Q18865_CAEEL
          Length = 431

 Score =  529 bits (1363), Expect = e-149,   Method: Compositional matrix adjust.
 Identities = 257/261 (98%), Positives = 258/261 (98%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEK TSANH
Sbjct: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKNTSANH 60

Query: 61  FVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           FVVRE+DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVK VLK AVERQKWELYHED
Sbjct: 61  FVVREADHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKVVLKHAVERQKWELYHED 120

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN
Sbjct: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIH 240
           LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIH
Sbjct: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIH 240

Query: 241 EKNLMHRDVAARNCLYGGGQV 261
           EKNLMHRDVAARNCLYGGGQV
Sbjct: 241 EKNLMHRDVAARNCLYGGGQV 261


>UniRef50_A8XAK9 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8XAK9_CAEBR
          Length = 417

 Score =  311 bits (797), Expect = 1e-83,   Method: Compositional matrix adjust.
 Identities = 160/243 (65%), Positives = 179/243 (73%), Gaps = 41/243 (16%)

Query: 20  DIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHK-VYVDKIGFP 78
           +  EML+KPG FL+RTSEP+KG+ RQF+LS +G  ++S NHFV+RES++K V+VD+ GF 
Sbjct: 53  ETSEMLHKPGDFLVRTSEPIKGQPRQFILSAIGSGQSSLNHFVIRESENKKVFVDQRGFS 112

Query: 79  TIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKG 138
           TIIELVNHYVS K+   TKD  VK VLK AVERQKWEL HEDV+LTKKLGEGAFGEVWKG
Sbjct: 113 TIIELVNHYVSQKDPIFTKDQKVKVVLKNAVERQKWELQHEDVQLTKKLGEGAFGEVWKG 172

Query: 139 KLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEP 198
           KLLK                                        HINVVKF+GVAAGTEP
Sbjct: 173 KLLK----------------------------------------HINVVKFYGVAAGTEP 192

Query: 199 LYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           LYVIMELADGGALDSAL K +FPMIKKYE+IYQAA GLAYIHEK LMHRDVAARNCLYGG
Sbjct: 193 LYVIMELADGGALDSALSKQNFPMIKKYEMIYQAACGLAYIHEKELMHRDVAARNCLYGG 252

Query: 259 GQV 261
           GQV
Sbjct: 253 GQV 255


>UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorhabditis briggsae
           RepID=A8XFT2_CAEBR
          Length = 577

 Score =  303 bits (775), Expect = 5e-81,   Method: Compositional matrix adjust.
 Identities = 155/266 (58%), Positives = 194/266 (72%), Gaps = 13/266 (4%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKK---TS 57
           M DKD+  + +YHGLLPREDI+ ML K G FL+R++EP +GE RQ+VLS +  ++     
Sbjct: 1   MFDKDIHTEPWYHGLLPREDIKAMLRKTGDFLIRSTEPKQGEARQYVLSAMQNEELEDAG 60

Query: 58  ANHFVVR-ESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL 116
             H+V+R  ++++++++  GF TI  LVN+Y++TK+           VLK  + +Q WE+
Sbjct: 61  VKHYVMRVNANNQIFLETKGFETITSLVNYYMTTKDPIKKM-----TVLKTPIVKQDWEI 115

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
            H  VELTKKLGEGAFGEVWKGK   I   N +    A+KTAKLES+ KEQIKEIMREAR
Sbjct: 116 EHSQVELTKKLGEGAFGEVWKGK---ITMKNGKVEDCAIKTAKLESLNKEQIKEIMREAR 172

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK-LHFPMIKKYELIYQAANG 235
           LMRNLDH NVVKFFGV AG EPLYVIMELAD GALDS L K  + P  KK E+IYQAA G
Sbjct: 173 LMRNLDHPNVVKFFGVGAGQEPLYVIMELADCGALDSYLQKNTNLPPAKKMEMIYQAACG 232

Query: 236 LAYIHEKNLMHRDVAARNCLYGGGQV 261
           + Y+HE+ L+HRD+AARNCLYGGGQV
Sbjct: 233 IGYMHERKLLHRDIAARNCLYGGGQV 258


>UniRef50_Q18684 Protein T13H10.1, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q18684_CAEEL
          Length = 533

 Score =  244 bits (624), Expect = 2e-63,   Method: Compositional matrix adjust.
 Identities = 132/258 (51%), Positives = 175/258 (67%), Gaps = 9/258 (3%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           L  + +YHGLLPRED++++L + G FL+R ++P  GE R+FVLSV         H+V+RE
Sbjct: 11  LAKEPWYHGLLPREDMKQLLTQRGDFLVRFTDPKVGEPRKFVLSVYVGVIEDIRHYVIRE 70

Query: 66  SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTK 125
            ++K  VDK  F +I +L+N+Y  +KE  +   G  + V+ + + R+ WE  H DV L K
Sbjct: 71  HNNKFAVDKKWFSSIADLLNYYHRSKEPVA---GGPETVIIRPIGREPWEKQHSDVTLIK 127

Query: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
           KLGEGAFGEV  G++ +I +   +    A+K AKLES+TKEQIKEIM EARLMR   H N
Sbjct: 128 KLGEGAFGEVQLGEI-RIGNTVKK---AAIKLAKLESLTKEQIKEIMHEARLMRKFKHPN 183

Query: 186 VVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKN 243
           VV F+GVAAG EPL VIMELAD GALDS L K     P+ KK+ ++ QA  GL Y+H   
Sbjct: 184 VVTFYGVAAGQEPLMVIMELADNGALDSYLKKNIGSLPISKKHTMVLQAGLGLEYLHSLQ 243

Query: 244 LMHRDVAARNCLYGGGQV 261
           ++HRD+A+RNCLYG GQV
Sbjct: 244 IIHRDIASRNCLYGNGQV 261


>UniRef50_Q20933 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q20933_CAEEL
          Length = 444

 Score =  231 bits (589), Expect = 2e-59,   Method: Compositional matrix adjust.
 Identities = 131/256 (51%), Positives = 167/256 (65%), Gaps = 16/256 (6%)

Query: 9   QKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVV-GEKKTSANHFVVRESD 67
           Q ++HGLLPRE+++ +L K G +L+RTSEP +G+ R  ++SV+  E      H+V+R SD
Sbjct: 6   QPFFHGLLPREEVKLLLQKNGDYLMRTSEP-QGQARHLIISVMQNETSQEVAHYVIRTSD 64

Query: 68  HKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKK 126
               + DKI F T+ ELVNH+   K S    +    +VL   + RQ WEL H D+ +TK 
Sbjct: 65  GAYSITDKIKFGTLTELVNHHKQAKIS----EEVASSVLVNPIGRQSWELNHADITMTKV 120

Query: 127 LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINV 186
           LGEGAFGEV     L  L      V VA+K AKLE +TKEQIKEI+ EARLMR  DH NV
Sbjct: 121 LGEGAFGEV----KLGTLKMGSTTVDVAIKVAKLEKVTKEQIKEIITEARLMRGFDHKNV 176

Query: 187 VKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAANGLAYIHEKN 243
           VK +GVAA  EPL V+MEL  GGALD  L K   + +P  +K ++I Q A GLAYIH KN
Sbjct: 177 VKCYGVAAIDEPLLVVMELVPGGALDKYLQKNSSVQWP--EKLDIIAQVAAGLAYIHSKN 234

Query: 244 LMHRDVAARNCLYGGG 259
           ++HRD+AARN LYG G
Sbjct: 235 IIHRDIAARNILYGKG 250


>UniRef50_A8WMP8 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8WMP8_CAEBR
          Length = 284

 Score =  220 bits (561), Expect = 3e-56,   Method: Compositional matrix adjust.
 Identities = 128/265 (48%), Positives = 165/265 (62%), Gaps = 19/265 (7%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN------ 59
           ++ + YYHGLLPRED   +L + G FL+R SEP  G ++ F+LS + + K+ +N      
Sbjct: 11  IIREGYYHGLLPREDAAALLTQNGDFLIRISEPTDGAEQNFILSCMTDDKSKSNDENPGM 70

Query: 60  -HFVVRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
            +FVV   + +  V +   FPTI +LV         F  K+      L + + RQ WEL 
Sbjct: 71  QNFVVGFQNGRYLVAENHSFPTIEKLV--------EFHKKNRIQNIFLNRPIMRQSWELD 122

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
           HE V + KKLGEGAFGEV  G+    +    +PV VAVK AK E +TK QIKE MREAR+
Sbjct: 123 HETVVILKKLGEGAFGEVSMGEYTPKMGG--KPVKVAVKQAKPEKLTKVQIKEFMREARI 180

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKY-ELIYQAANGL 236
           M+NL H NVVKF+GVAA  EPLY++MELA  G+LD  L K      + Y E+I QAA GL
Sbjct: 181 MKNLSHENVVKFYGVAAVQEPLYMVMELASNGSLDGYLKKNPDLRPEVYNEMILQAAWGL 240

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQV 261
            Y HEKN++HRD+A RNCLYG  QV
Sbjct: 241 EYCHEKNIIHRDMAVRNCLYGDRQV 265


>UniRef50_P34265 Probable tyrosine-protein kinase kin-31 n=4 Tax=Caenorhabditis
           RepID=KIN31_CAEEL
          Length = 437

 Score =  205 bits (521), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 111/259 (42%), Positives = 164/259 (63%), Gaps = 13/259 (5%)

Query: 9   QKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKK----TSANHFVVR 64
           + Y+HGL+ RED+ ++L+  G +++R S+P  GE R ++LSV+   K    +S  HFV+ 
Sbjct: 18  EAYFHGLIQREDVFQLLDNNGDYVVRLSDPKPGEPRSYILSVMFNNKLDENSSVKHFVIN 77

Query: 65  ESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
             ++K +V+  + F TI ++++HY  ++             +   V RQ WEL H ++ +
Sbjct: 78  SVENKYFVNNNMSFNTIQQMLSHYQKSRTEILEA-----CKILHPVRRQFWELDHGNIVI 132

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
            KKLGEGAFGEV  G +        + V VAVK  K + + K+QIK+ + EAR MRNL H
Sbjct: 133 EKKLGEGAFGEVSSGVMK--FKRGGRLVKVAVKQVKTDGIGKDQIKDFLMEARTMRNLGH 190

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-FPMIKKYELIYQAANGLAYIHEK 242
            N+V+F G+A   EPL+++MELA GGALDS L      P+ K++E++ QAA GL YIH K
Sbjct: 191 PNIVRFLGIAVLQEPLFLVMELATGGALDSYLKHNELLPIDKRHEMLLQAAWGLEYIHGK 250

Query: 243 NLMHRDVAARNCLYGGGQV 261
            ++HRD+AARNCLYG G+V
Sbjct: 251 PMLHRDIAARNCLYGDGKV 269


>UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax=Brugia malayi
           RepID=A8P4D4_BRUMA
          Length = 428

 Score =  197 bits (501), Expect = 3e-49,   Method: Compositional matrix adjust.
 Identities = 111/259 (42%), Positives = 160/259 (61%), Gaps = 9/259 (3%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA-N 59
           M   +L  + YYHGLLPRED+  +L   G FL+R+SE    + RQ ++S++ EK+ +   
Sbjct: 1   MGGGNLEDENYYHGLLPREDLPHLLINEGDFLVRSSETAPNQPRQVIISILVEKRGAILR 60

Query: 60  HFVVRESDHKVYVD--KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
           H VV+++ +  YV   +  F ++ EL+  Y    E   +     KAVLK+A+ R  WEL 
Sbjct: 61  HIVVQQNAYGKYVTDARASFDSVPELIQFYQKCGEPVLST--VPKAVLKRAITRPPWELR 118

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
           HE V +  K+GEG FGEV+ GK  K+     + + VA+K AK    +KE+IKE+M+EARL
Sbjct: 119 HETVIIENKIGEGEFGEVFSGKY-KL--PTGRVIEVAIKLAKTAETSKEKIKEMMKEARL 175

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE-LIYQAANGL 236
           MRN +H NV++ +GV    +PL ++MEL DGGALD  L K    +  K E ++   A G+
Sbjct: 176 MRNYEHPNVIRMYGVCVEHDPLLIVMELVDGGALDDFLKKNRVSVKDKVEKMVAGGAWGV 235

Query: 237 AYIHEKNLMHRDVAARNCL 255
            Y+H KN +HRD+AARNCL
Sbjct: 236 EYLHSKNCIHRDIAARNCL 254


>UniRef50_A8NEQ9 Protein kinase domain containing protein (Fragment) n=1 Tax=Brugia
           malayi RepID=A8NEQ9_BRUMA
          Length = 293

 Score =  191 bits (486), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 104/203 (51%), Positives = 140/203 (68%), Gaps = 7/203 (3%)

Query: 60  HFVV-RESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
           H+V+ R  + K  ++K GF ++ E++N +++  ES   K+  V   L   + RQ WEL+H
Sbjct: 3   HYVIQRTPNGKYTIEKYGFDSVPEMINFHLNKHESL-VKNAEV--FLTTPILRQTWELHH 59

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           EDVE TKKLGEGAFGEV  G+L      N + V VA+K AKLE++TKEQIKEIM+EARL 
Sbjct: 60  EDVEPTKKLGEGAFGEVHLGRLRL---RNGRKVDVAIKLAKLEALTKEQIKEIMKEARLH 116

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAY 238
           R  DH NV K +GVAAG EPL ++MELA+ GALDS L K H  + +K ++   A+ GL Y
Sbjct: 117 RTFDHPNVCKCYGVAAGQEPLMIVMELANKGALDSYLQKNHVSVEQKMDMCLGASWGLEY 176

Query: 239 IHEKNLMHRDVAARNCLYGGGQV 261
           +H K ++HRD+AARNCL+G  +V
Sbjct: 177 LHAKPVLHRDIAARNCLFGDNKV 199


>UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QDY0_BRUMA
          Length = 384

 Score =  184 bits (468), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 101/248 (40%), Positives = 154/248 (62%), Gaps = 11/248 (4%)

Query: 10  KYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHK 69
           ++YHGLLPR+DI  +L+K GQFL+R +E  KGE  Q VLSV    KT   HF++R  D K
Sbjct: 12  EWYHGLLPRKDINILLSKQGQFLVRETEIKKGEGLQLVLSVKWNDKTM--HFIIRHVDGK 69

Query: 70  VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
           V+++K  F +I  L+ +++ +K+  + + G   A+L  AV RQ WE+ HE +EL + LGE
Sbjct: 70  VFIEKRQFNSIHALIRYHLVSKDPITDQSG---AMLLHAVPRQSWEVRHEQIELHELLGE 126

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           GA   V+KG    I   +     VA+K  K   + +E +++I REAR+MR L+H NVV+ 
Sbjct: 127 GAMSAVYKG----IFRGDESEKQVAIKVRKGRRLDRETVEQICREARIMRRLEHPNVVRL 182

Query: 190 FGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY--QAANGLAYIHEKNLMHR 247
           +G+A   EP+ ++MEL   G+LD  L      +  + +L +    A+GL ++H   ++HR
Sbjct: 183 YGIAISKEPIMLLMELLKDGSLDVFLVTKGSKLSTREKLYFCLDIASGLEFLHNNGVIHR 242

Query: 248 DVAARNCL 255
           D++ARNCL
Sbjct: 243 DISARNCL 250


>UniRef50_Q9N4T6 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q9N4T6_CAEEL
          Length = 448

 Score =  180 bits (456), Expect = 5e-44,   Method: Compositional matrix adjust.
 Identities = 103/265 (38%), Positives = 156/265 (58%), Gaps = 22/265 (8%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEK---RQFVLSVV--------GEK 54
           L H ++YHG LPRED+Q  L  PG FLLR SE V+GE    R+ +LS++         E 
Sbjct: 74  LRHFEFYHGFLPREDLQSTLQNPGDFLLRVSEVVEGENKVNREIILSLIPIQEEGKEDED 133

Query: 55  KTSANHFVVRESDHKVYVDKI-GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK 113
           K    + V++ + +  + +    F +I EL+N+Y+  K + S    T +  L   + +Q 
Sbjct: 134 KIRTRNVVIKRAGYLFFCETTRSFDSIFELINYYM--KNTGSCSSATFQ--LLNPILQQP 189

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLES-MTKEQIKEIM 172
           WE  H DV + K LGEGAFG+V  G  LK+ D ++  V VA+K  K+ + ++K +IKE+M
Sbjct: 190 WEYMHSDVTIGKVLGEGAFGKVCSG-TLKLKDGSN--VEVAIKMTKVSAFLSKMKIKEMM 246

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIY 230
            EAR +RN +H NVV+ +GVA   +PLY+++EL  GG+L   + K      + ++     
Sbjct: 247 NEARFIRNFNHKNVVRLYGVAHHEQPLYILLELVKGGSLQDHMKKEKGAVTIAERIRFCC 306

Query: 231 QAANGLAYIHEKNLMHRDVAARNCL 255
            A  G+ Y+H+ N +HRD+AARNCL
Sbjct: 307 GAGRGIEYLHQNNCIHRDIAARNCL 331


>UniRef50_O17755 Protein F01D4.3, partially confirmed by transcript evidence n=2
           Tax=Caenorhabditis elegans RepID=O17755_CAEEL
          Length = 561

 Score =  172 bits (435), Expect = 1e-41,   Method: Compositional matrix adjust.
 Identities = 101/264 (38%), Positives = 153/264 (57%), Gaps = 27/264 (10%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGE---KRQFVLSVV---------GEKKTSA 58
           +YHG LPRED+   L+  G +L+R SE V+GE    R+ +LS++          EKK   
Sbjct: 150 FYHGFLPREDLHSTLHNSGDYLIRVSEVVEGETKVNREVILSLIPIQSDGKEDTEKKNCR 209

Query: 59  NHFVVRESDHKVYVDKI-GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
           N  V++   +K + +    F ++ +L+ +Y  T  S S  +G  +  LK  + +Q WE  
Sbjct: 210 N-VVIKRVGNKCFCEPTRTFESVTDLIKYY--TDNSGSCSNGRFQ--LKNPILQQPWEYM 264

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLES-MTKEQIKEIMREAR 176
           H DV   K LGEGAFG+V+ G  LK+ D +     VA+K  K+ + ++K +IKE+M EAR
Sbjct: 265 HSDVTAGKVLGEGAFGKVFSG-TLKLKDGSS--AEVAIKMTKVSAFLSKIKIKEMMNEAR 321

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-----FPMIKKYELIYQ 231
            +RN +H NVV+ +GVA   +PLY+++EL  GG+L   + K        P+ +K      
Sbjct: 322 FIRNFNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDHMKKAKATGTVVPIAEKVRFCIG 381

Query: 232 AANGLAYIHEKNLMHRDVAARNCL 255
           AA G+ Y+H+ N +HRD+AARNCL
Sbjct: 382 AARGIEYLHQNNCIHRDIAARNCL 405


>UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NNY7_BRUMA
          Length = 303

 Score =  171 bits (434), Expect = 2e-41,   Method: Compositional matrix adjust.
 Identities = 102/251 (40%), Positives = 148/251 (58%), Gaps = 14/251 (5%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV-RESDHK 69
           YYHGL+PR DI+ +L K G FLLR +E   GE    VL++      +  HF+V ++ D  
Sbjct: 24  YYHGLIPRTDIEPLLKKEGDFLLRKTELTPGE---IVLAISVRHNNAVRHFMVNQDQDGS 80

Query: 70  VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
            Y +     ++ +L+ +Y STKE  S    + +A L++ +ER +W L H+ + L KKLGE
Sbjct: 81  FYCEHHHEKSVSDLIQYYKSTKEPLS---ASSQARLRRPIERPQWLLNHDSIRLVKKLGE 137

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           GAFGEV+    L       +   VAVKT + E+ T+E   + M+EARLMR  +H +VV+ 
Sbjct: 138 GAFGEVF----LAEYSFGTEKQEVAVKTMRQEA-TREARLKFMKEARLMRRYEHKHVVRI 192

Query: 190 FGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYELIYQAANGLAYIHEKNLMHR 247
            GVA    PL +IME   GG+L S L   K+  P+  K     +AA+G+AY+H++  +HR
Sbjct: 193 LGVAVHEHPLMIIMENCPGGSLLSYLRKEKVKVPLAMKLRFATEAADGMAYLHKQKCIHR 252

Query: 248 DVAARNCLYGG 258
           D+AARN L  G
Sbjct: 253 DIAARNVLLSG 263


>UniRef50_Q9TYX4 Putative uncharacterized protein R11E3.1 n=3 Tax=root
           RepID=Q9TYX4_CAEEL
          Length = 549

 Score =  170 bits (431), Expect = 3e-41,   Method: Compositional matrix adjust.
 Identities = 108/289 (37%), Positives = 154/289 (53%), Gaps = 40/289 (13%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSE------PVKGEKRQFVLSVV------ 51
           K L    +YHG LPR+D+  ++   G +L+R SE         G KR  +LSV       
Sbjct: 73  KSLQAMPFYHGFLPRDDLGVIIRNEGDYLIRVSEITTKKEGTTGIKRDIILSVCSSERGG 132

Query: 52  ------------------GEKKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKES 93
                             GE+K    + V+R  D K  +    FPTI  L+ +Y  T  +
Sbjct: 133 TETEQTNTKSDAKSELNLGERK--MRNMVIRRFDGKFGIKGNLFPTIEALLANYHVTN-A 189

Query: 94  FSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLV 153
             TK+      LK  ++ Q WE  H  V+L  KLGEGA+GEV KG    +L   ++ + V
Sbjct: 190 LETKEN---RFLKTPIDLQVWENRHSAVKLGDKLGEGAYGEVRKG----VLHRKNKKLDV 242

Query: 154 AVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDS 213
           AVK  K   + K +I+E+M EARLMRN  H N+V+FFGVA   +PLY+++EL +GGAL++
Sbjct: 243 AVKLMKGGELNKMKIREMMNEARLMRNFKHKNIVRFFGVAVVEQPLYILLELVNGGALNT 302

Query: 214 ALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            L K     ++   +   AA GL Y+H  + +HRD+AARNCLY   +V+
Sbjct: 303 YLQKNKVSDLELMRMCLGAAQGLQYLHANHCIHRDIAARNCLYSNDKVV 351


>UniRef50_A8PJL3 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8PJL3_BRUMA
          Length = 668

 Score =  170 bits (431), Expect = 4e-41,   Method: Compositional matrix adjust.
 Identities = 110/260 (42%), Positives = 149/260 (57%), Gaps = 29/260 (11%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKV 70
           Y+HG LPRED   +    G FLLRT+E   GE R+  LSV    K    H ++      +
Sbjct: 243 YFHGFLPREDANMLCILDGDFLLRTTEVFSGEDRKLCLSVAWHGK----HHII------L 292

Query: 71  YVDKI----------GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           + DK+           FPTI +LVN+Y   +     +    + +LK  +  Q WEL H+ 
Sbjct: 293 HYDKLKNRYGIKPSRTFPTITDLVNYYAQHRFKILKE----RVLLKNPIVTQSWELKHQQ 348

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           ++L +KLGEGAFGEV    L  +    H  V  AVK  K ++MTKE+++E M E R++RN
Sbjct: 349 LQLLQKLGEGAFGEVHSANL-ALTPRFH--VKAAVKVLKCDAMTKEKVREAMCEVRMLRN 405

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELIYQAANGLAY 238
           L H N+V+F+GVA   EPL ++MEL   GALD  L K   +  M  K  +I  AA GLAY
Sbjct: 406 LRHENIVRFYGVANRKEPLMIVMELVKEGALDVFLRKNGNNLSMKNKLLMIRDAAFGLAY 465

Query: 239 IHEKNLMHRDVAARNCLYGG 258
           +H +N+MHRD+A RNCLY G
Sbjct: 466 LHSQNIMHRDLATRNCLYTG 485


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score =  167 bits (424), Expect = 2e-40,   Method: Compositional matrix adjust.
 Identities = 102/266 (38%), Positives = 152/266 (57%), Gaps = 21/266 (7%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           +++K L  Q +YHG +PR + QE+L K G FL+R S    GE   +VLSV  + +    H
Sbjct: 450 ISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGE---YVLSVYSDGQR--RH 504

Query: 61  FVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           F+++  D+    +  GF  I +L++H+ +TK+  + K G V  +L    + +KW L HED
Sbjct: 505 FIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVV--LLNPIPKDKKWILSHED 562

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V L + LG+G FGEV+KG L            VAVKT K E + +E   + ++EA++++ 
Sbjct: 563 VILGELLGKGNFGEVYKGTL-------KDKTSVAVKTCK-EDLPQELKIKFLQEAKILKQ 614

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK----LHFPMIKKYELIYQAANGL 236
            DH N+VK  GV    +P+Y+IMEL  GG   + L +    L    + K+ L   AA G+
Sbjct: 615 YDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSL--DAAAGM 672

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQVL 262
            Y+  KN +HRD+AARNCL G   VL
Sbjct: 673 LYLESKNCIHRDLAARNCLVGENNVL 698


>UniRef50_Q22765 Protein T25B9.4, partially confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=Q22765_CAEEL
          Length = 546

 Score =  159 bits (403), Expect = 7e-38,   Method: Compositional matrix adjust.
 Identities = 98/278 (35%), Positives = 158/278 (56%), Gaps = 29/278 (10%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKG--EKRQFVLSVVGEKKTSA- 58
           T K L++QK+YHG LPRED+  +L K G F+ R +E   G  +K+  VLS+    ++ A 
Sbjct: 7   TFKWLMNQKFYHGYLPREDLPYVLKKKGDFIFRVTERTVGKEQKKDIVLSIAWPTESVAM 66

Query: 59  ------NHFVVRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER 111
                  ++++  S + V++D KI F +I  L NHY         K+  V   L+  + R
Sbjct: 67  IDTKDIKNYLIERSANSVWLDLKISFHSIDALYNHY--------RKNELVHPNLRIKLGR 118

Query: 112 QK----WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLE-SMTKE 166
                 WE  H  + L KK+G+GA+GEV+KG + +     ++    A+K  + +     E
Sbjct: 119 PICLFFWEFKHSQINLIKKVGKGAYGEVFKGTVTR----GNKTFNGAIKAMRKDLDAGNE 174

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIK 224
           ++KE+M EARLMR+L+H N+V+  G+A   +P+Y+++E  +GG LDS L K      M +
Sbjct: 175 KMKEVMAEARLMRSLNHPNIVRCRGIAVLEQPVYIVIEFINGGGLDSYLKKNSQTLTMDQ 234

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           K  +   AA G+ ++H  +++HRD+AARNCLY    ++
Sbjct: 235 KNRMAISAAWGIEFMHSHDIIHRDIAARNCLYDNKNLV 272


>UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, partial n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793081
          Length = 770

 Score =  159 bits (402), Expect = 8e-38,   Method: Compositional matrix adjust.
 Identities = 91/257 (35%), Positives = 152/257 (59%), Gaps = 22/257 (8%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVV--GEKKTSANHF 61
           K L+ ++++HG+LPRE++  +L K G FL+R  E  + ++ Q VLSV   G K     HF
Sbjct: 530 KSLIEEEWFHGVLPREEVVRLLTKEGDFLVR--ETTRNDENQTVLSVCWGGHK-----HF 582

Query: 62  VVRE-SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           +V+  S+ +   +   FPTI EL+ +   +    +++ G   A+L+Q + R++WEL ++D
Sbjct: 583 IVQTTSEGEFRFEGPSFPTIQELITYQYQSALPVTSRSG---AILRQPIPRERWELNNDD 639

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V L +K+G G FG+V+K +L      N +    AVKT ++ ++  E  K+ ++E R+++ 
Sbjct: 640 VLLLEKIGRGNFGDVYKARLRS---TNKE---AAVKTCRV-TVPDEHKKKFLQEGRILKQ 692

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAY 238
            DH NVVK  G+    +P+ ++MEL  GG+L S L        +++   +   AA G+ Y
Sbjct: 693 YDHPNVVKLIGICVQKQPIMIVMELVAGGSLLSYLRNNSKTLSVLQLVSMCRDAAAGMMY 752

Query: 239 IHEKNLMHRDVAARNCL 255
           +  KN +HRD+AARNCL
Sbjct: 753 LESKNCIHRDLAARNCL 769


>UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateria RepID=FPS_DROME
          Length = 1325

 Score =  158 bits (399), Expect = 2e-37,   Method: Compositional matrix adjust.
 Identities = 92/260 (35%), Positives = 155/260 (59%), Gaps = 24/260 (9%)

Query: 2    TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVV--GEKKTSAN 59
            T++ L  ++++HG+LPRE++  +LN  G FL+R  E ++ E+ Q VLSV   G K     
Sbjct: 951  TNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVR--ETIRNEESQIVLSVCWNGHK----- 1003

Query: 60   HFVVRESDHKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
            HF+V+ +    +  +   F +I EL+ H   ++   + K G   A+L++ V R++WEL +
Sbjct: 1004 HFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSG---AILRRPVCRERWELSN 1060

Query: 119  EDVELTKKLGEGAFGEVWKGKLLKI-LDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
            +DV L +++G G FG+V+K KL    LD       VAVKT ++ ++  EQ ++ ++E R+
Sbjct: 1061 DDVVLLERIGRGNFGDVYKAKLKSTKLD-------VAVKTCRM-TLPDEQKRKFLQEGRI 1112

Query: 178  MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE--LIYQAANG 235
            ++  DH N+VK  G+    +P+ ++MEL  GG+L + L K    +  + +  +   AA G
Sbjct: 1113 LKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAG 1172

Query: 236  LAYIHEKNLMHRDVAARNCL 255
            + Y+  KN +HRD+AARNCL
Sbjct: 1173 MRYLESKNCIHRDLAARNCL 1192


>UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA
          Length = 1315

 Score =  157 bits (398), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 93/266 (34%), Positives = 157/266 (59%), Gaps = 21/266 (7%)

Query: 2    TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVV--GEKKTSAN 59
            T++ L  ++++HG+LPRE++  +L   G FL+R  E  + ++ Q VLSV   G K     
Sbjct: 942  TNRPLHEEEWFHGVLPREEVVRLLRNEGDFLVR--ETTRNDESQTVLSVCWNGHK----- 994

Query: 60   HFVVRESDHKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
            HF+V+ +    Y  +   FP+I EL+ H   ++   + + G   AVL++ V R++WEL +
Sbjct: 995  HFIVQTTAEGHYRFEGPAFPSIQELIVHQYQSELPVTGRSG---AVLRKPVLRERWELSN 1051

Query: 119  EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
            +DV L  K+G G FG+V+K KL      + +  LVAVKT ++ ++ +EQ ++ ++E R++
Sbjct: 1052 DDVILLDKIGRGNFGDVYKAKL-----KSSKNTLVAVKTCRM-TLPEEQKRKFLQEGRIL 1105

Query: 179  RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK--YELIYQAANGL 236
            +  DH N+VK  G+    +P+ ++MEL  GG+L   L K    + ++    +   AA G+
Sbjct: 1106 KQYDHPNIVKLIGICVQKQPIMIVMELVAGGSLLMFLRKNASTLGQRQMMGMCRDAAAGM 1165

Query: 237  AYIHEKNLMHRDVAARNCLYGGGQVL 262
             Y+  KN +HRD+AARNCL G   ++
Sbjct: 1166 RYLESKNCIHRDLAARNCLIGSENIV 1191


>UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=4 Tax=Endopterygota
           RepID=P18106-3
          Length = 475

 Score =  157 bits (398), Expect = 3e-37,   Method: Compositional matrix adjust.
 Identities = 90/258 (34%), Positives = 153/258 (59%), Gaps = 20/258 (7%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           T++ L  ++++HG+LPRE++  +LN  G FL+R  E ++ E+ Q VLSV         HF
Sbjct: 101 TNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVR--ETIRNEESQIVLSVCW---NGHKHF 155

Query: 62  VVRESDHKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           +V+ +    +  +   F +I EL+ H   ++   + K G   A+L++ V R++WEL ++D
Sbjct: 156 IVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSG---AILRRPVCRERWELSNDD 212

Query: 121 VELTKKLGEGAFGEVWKGKLLKI-LDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           V L +++G G FG+V+K KL    LD       VAVKT ++ ++  EQ ++ ++E R+++
Sbjct: 213 VVLLERIGRGNFGDVYKAKLKSTKLD-------VAVKTCRM-TLPDEQKRKFLQEGRILK 264

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE--LIYQAANGLA 237
             DH N+VK  G+    +P+ ++MEL  GG+L + L K    +  + +  +   AA G+ 
Sbjct: 265 QYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMR 324

Query: 238 YIHEKNLMHRDVAARNCL 255
           Y+  KN +HRD+AARNCL
Sbjct: 325 YLESKNCIHRDLAARNCL 342


>UniRef50_A8Q767 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q767_BRUMA
          Length = 500

 Score =  156 bits (395), Expect = 5e-37,   Method: Compositional matrix adjust.
 Identities = 105/274 (38%), Positives = 152/274 (55%), Gaps = 20/274 (7%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLS--VVGEKKTSANHF 61
           K +L + YYHG LPRED+  +L + G F++R ++    +  + +LS  V  +   SA   
Sbjct: 20  KKVLDESYYHGFLPREDLPCLLEQVGDFIIRITQLKPRDPCELILSLRVSDQNSPSAIRH 79

Query: 62  VV----RESDHKV---YVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKW 114
           VV    +  D K+      +  F ++ EL++ YVS+K+  + +  T + +  + + RQ W
Sbjct: 80  VVIHRLKGKDGKIEWLTNQENRFNSLKELIDAYVSSKKPINPEIKTSQLI--RPIARQSW 137

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLV----AVKTAKLESMTKEQIKE 170
           E  HE++ L   LGEG FGEV  G+   I+D    PV V     +K  K     KE+IKE
Sbjct: 138 EFLHENIILKDMLGEGQFGEVRAGEA--IIDGKKIPVAVKIAKTIKDKKNIQQAKEKIKE 195

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYE- 227
           +M EARLMR  DH NVVK  GVA   EPL +I+EL +GG L   L   K +    +K E 
Sbjct: 196 MMHEARLMRYFDHENVVKIHGVAVCREPLMIIIELVNGGCLSDVLESRKGNIDEDEKIEN 255

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
           +   +A GL YIH + ++HRD+AARN LY   +V
Sbjct: 256 MSLGSARGLEYIHAQRIIHRDIAARNVLYTENRV 289


>UniRef50_A8PMN8 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8PMN8_BRUMA
          Length = 420

 Score =  156 bits (395), Expect = 6e-37,   Method: Compositional matrix adjust.
 Identities = 86/251 (34%), Positives = 146/251 (58%), Gaps = 12/251 (4%)

Query: 9   QKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES-- 66
           + +YHG +   + + +L   G FL+R +E + GE  Q+V++V+ E      +F+++++  
Sbjct: 33  EPFYHGFMSNNECKPLLTNAGDFLVRRAE-IDGEM-QYVITVLPENSNEITNFIIKKTRP 90

Query: 67  DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKK 126
            H  YV    F TI +L+ ++   K+  + ++      + + + R  W+L HE +E  KK
Sbjct: 91  KHLYYVYIYAFKTISDLIAYHSRMKKPLNNEN----VCILKGIARSDWQLAHEQIERNKK 146

Query: 127 LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINV 186
           LGEGAFGEVW+G L   +   + PV  A+KT    +++ ++  + +REA LM  L H N+
Sbjct: 147 LGEGAFGEVWEGTLNLGVFRGYIPV--AIKTLHSGNISADERIKFLREANLMLKLSHPNI 204

Query: 187 VKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQ--AANGLAYIHEKNL 244
           +KF+GVA   +P+ ++ME A GG+L + +     P     ++ Y   AA+GLAY+    +
Sbjct: 205 IKFYGVATLKDPIMIVMEFASGGSLLARVQNTKRPPTDADKIRYCAGAASGLAYLETMQI 264

Query: 245 MHRDVAARNCL 255
           +HRD+AARNCL
Sbjct: 265 IHRDIAARNCL 275


>UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria RepID=Q2VXS8_HUMAN
          Length = 764

 Score =  155 bits (392), Expect = 1e-36,   Method: Compositional matrix adjust.
 Identities = 92/263 (34%), Positives = 154/263 (58%), Gaps = 22/263 (8%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           K L  Q +YHG +PR ++ E+L   G FL+R S+     K+++VLSV+ +      HF++
Sbjct: 395 KPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ----GKQEYVLSVLWDGL--PRHFII 448

Query: 64  RESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
           +  D+   ++  GFP+I  L++H +ST++  + K G V   L +AV + KW L HED+ L
Sbjct: 449 QSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVV---LHRAVPKDKWVLNHEDLVL 505

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
            +++G G FGEV+ G+L     A++   LVAVK+ + E++  +   + ++EAR+++   H
Sbjct: 506 GEQIGRGNFGEVFSGRL----RADN--TLVAVKSCR-ETLPPDLKAKFLQEARILKQYSH 558

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSAL----GKLHFPMIKKYELIYQAANGLAYI 239
            N+V+  GV    +P+Y++MEL  GG   + L     +L    +   +++  AA G+ Y+
Sbjct: 559 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL--LQMVGDAAAGMEYL 616

Query: 240 HEKNLMHRDVAARNCLYGGGQVL 262
             K  +HRD+AARNCL     VL
Sbjct: 617 ESKCCIHRDLAARNCLVTEKNVL 639


>UniRef50_Q23554 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q23554_CAEEL
          Length = 419

 Score =  152 bits (385), Expect = 9e-36,   Method: Compositional matrix adjust.
 Identities = 92/248 (37%), Positives = 138/248 (55%), Gaps = 10/248 (4%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE-SDHK 69
           +YHGLLPR DI  +L   G FL+RTS  V  +  + VLSV  + K   +H+ ++E  D  
Sbjct: 32  WYHGLLPRADINTLLENDGDFLVRTSHIVGQDSAKTVLSV--KWKGKCHHWQLQEKEDGS 89

Query: 70  VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
           + +++  F +++++V      +   S       A+L   + +Q WEL H+ ++L K LGE
Sbjct: 90  IVIEERKFESVLDMVTTLRMKRLPVS---ANCPALLLNPINKQDWELRHDQIKLGKMLGE 146

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           GAFG V+K           + V V V     +  T+  I+++ +EAR+MR   H NVV F
Sbjct: 147 GAFGGVYKAAFY--CKGEKRMVAVKVNKGNEKISTRAMIEDVCKEARIMRQYQHPNVVCF 204

Query: 190 FGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYELIYQAANGLAYIHEKNLMHR 247
           FGV    EP+ ++MELA  GALDS L   K +  +  K +  + A+ GL Y+H+   +HR
Sbjct: 205 FGVCVEKEPIMLVMELASQGALDSFLKNEKNNVSLRDKLKYSFDASKGLEYLHQHGCIHR 264

Query: 248 DVAARNCL 255
           DVAARN L
Sbjct: 265 DVAARNFL 272


>UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7PSP3_IXOSC
          Length = 674

 Score =  152 bits (383), Expect = 1e-35,   Method: Compositional matrix adjust.
 Identities = 91/256 (35%), Positives = 151/256 (58%), Gaps = 20/256 (7%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           L  + ++HG+LPRE++  +L   G +L+R  E ++ E++Q VLSV  +      HF+V+ 
Sbjct: 308 LQDEDWFHGVLPREEVVRLLVNNGDYLVR--ETMRNEEKQVVLSVCWQ---GHKHFIVQT 362

Query: 66  -SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT 124
            SD K   +   F T+ EL+ +        ++K G   A+L+  + R++WEL ++DVEL 
Sbjct: 363 TSDGKYRFEGPAFGTVQELIVYQHHLGLPVTSKSG---AILQNPIFRERWELNNDDVELV 419

Query: 125 KKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHI 184
           +K+G G FG+V++  L      + Q   VAVKT ++ ++  E  K+ ++E R+++  DH 
Sbjct: 420 EKIGRGNFGDVYRAVL------HPQRTEVAVKTCRV-NLPDEHKKKFLQEGRILKQYDHP 472

Query: 185 NVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELI---YQAANGLAYIHE 241
           N+VKF G+    +P+ ++MEL  GG+L + L +   P +   EL+      A G+AY+  
Sbjct: 473 NIVKFIGICVQKQPIMIVMELVPGGSLLAFL-RNQGPKLNPKELLNMCIDTAAGMAYLES 531

Query: 242 KNLMHRDVAARNCLYG 257
           KN +HRD+AARNCL G
Sbjct: 532 KNCIHRDLAARNCLVG 547


>UniRef50_Q9XXE5 Protein Y43C5B.2, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q9XXE5_CAEEL
          Length = 245

 Score =  151 bits (381), Expect = 3e-35,   Method: Compositional matrix adjust.
 Identities = 89/222 (40%), Positives = 130/222 (58%), Gaps = 16/222 (7%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSV---VGEKKTS 57
           M    +  + YYHG LPRED++ +L   G F++R SEP  G  R  +LSV   V   +  
Sbjct: 8   MQRPSIEKEPYYHGFLPREDVKTVLKNNGDFVIRISEPQAGSPRSNILSVMHCVPPMEEE 67

Query: 58  ANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
             H+V++    K++++K+ F +I E+V  +++ KES   KD      L +A+ RQ WEL 
Sbjct: 68  IKHYVIKTKGDKIFIEKVSFLSIPEMVEWHLTKKESVQ-KD----VFLIKAISRQAWELD 122

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
           H+++E  KKLGEGAFGEV  G +        + V VA+K AKL ++TKEQIKE M EAR+
Sbjct: 123 HDNIEPLKKLGEGAFGEVMMGTMK--FRKGGKSVQVAIKQAKLSNLTKEQIKEFMGEARV 180

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH 219
           MR+L H +VV+F+GV          + +A   +L+  L K H
Sbjct: 181 MRSLSHPHVVRFYGVPRRR------VNVALCRSLNEFLAKCH 216


>UniRef50_UPI000186DA97 tyrosine-protein kinase transforming protein FPS, putative n=1
           Tax=Pediculus humanus corporis RepID=UPI000186DA97
          Length = 850

 Score =  149 bits (375), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 88/259 (33%), Positives = 152/259 (58%), Gaps = 22/259 (8%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVV--GEKKTSANHF 61
           K L+ ++++HG+LPRE++  +L   G FL+R  E  + ++ Q VLSV   G K     HF
Sbjct: 479 KALIDEEWFHGVLPREEVVRLLRHEGDFLVR--ETTRNDECQTVLSVAWGGHK-----HF 531

Query: 62  VVRES-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           +V+ + +     +   FPTI EL+ +   +    +++ G   A+LK+ + R+ WEL ++D
Sbjct: 532 IVQTNLEGHFRFEGPSFPTIQELILYQYQSGLPVTSRSG---AILKKPILREVWELNNDD 588

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V+L  K+G G FG+V+K KL      N +   VAVKT ++ ++  E  ++ ++E R+++ 
Sbjct: 589 VQLLDKIGRGNFGDVYKAKL---KSTNQE---VAVKTCRV-ALPDENKRKFLQEGRILKQ 641

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK--YELIYQAANGLAY 238
            DH N+VK  G+    +P+ ++MEL  GG+L + L      + +K   ++    A+G+ Y
Sbjct: 642 YDHPNIVKLIGICVQKQPIMIVMELVPGGSLLTFLRNNASTLTQKLLLKMCRDTASGMQY 701

Query: 239 IHEKNLMHRDVAARNCLYG 257
           +  +N +HRD+AARNCL G
Sbjct: 702 LESRNCIHRDLAARNCLIG 720


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score =  147 bits (372), Expect = 2e-34,   Method: Compositional matrix adjust.
 Identities = 83/262 (31%), Positives = 143/262 (54%), Gaps = 18/262 (6%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           K +  Q ++HG +PR +   +L + G FLLR S    G+   FVLS   + +    HF V
Sbjct: 463 KTIKEQTWFHGTIPRTESLRLLQQDGDFLLRESNNSLGD---FVLSAKADGQ--VRHFKV 517

Query: 64  RESDHKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           + +D+ +Y  +   FPT++ L++H+   +E  + +      +L   + + KW+L H+D  
Sbjct: 518 QVTDNGMYRFEADQFPTVLNLISHHYQKREPVTKR---TNCLLLNPICKDKWQLSHDDFT 574

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           +  K+G+G FGEV+K   ++      +   VAVKT K E++     ++ + EA++++  D
Sbjct: 575 IDCKIGQGNFGEVYKALFIR------ENYYVAVKTCK-ETVDNNTKEKFLMEAKILKGYD 627

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKY--ELIYQAANGLAYIH 240
           H N+V+  GV    +P+Y++ME   GG L   L +    +  ++  +  + A  GLAY+ 
Sbjct: 628 HKNIVRLIGVCTDRQPIYIVMEFVSGGDLVKYLKQNQHELCPRHLVQFCHDACMGLAYLE 687

Query: 241 EKNLMHRDVAARNCLYGGGQVL 262
           +K  +HRDVAARNCL     V+
Sbjct: 688 DKKCIHRDVAARNCLVSDDLVV 709


>UniRef50_Q4S351 Chromosome 4 SCAF14752, whole genome shotgun sequence n=2
           Tax=Tetraodon nigroviridis RepID=Q4S351_TETNG
          Length = 810

 Score =  147 bits (370), Expect = 4e-34,   Method: Compositional matrix adjust.
 Identities = 95/263 (36%), Positives = 137/263 (52%), Gaps = 46/263 (17%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           +++ L  Q++YHG +PR + QE+L + G+FL        G+ R                 
Sbjct: 470 SERPLAEQEWYHGAIPRTEAQELLRQQGEFL--------GQYR----------------- 504

Query: 62  VVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDV 121
                      +  GF TI +L+ H+ S+K+  + K G V  +L   V+ +KW L HEDV
Sbjct: 505 ----------FEGTGFTTIPQLIEHHFSSKQVITKKSGVV--LLNPVVKDKKWILNHEDV 552

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
            L + LG+G FGEV+KG L +    +  PV  AVKT K E +  E     + EAR+++  
Sbjct: 553 VLGELLGKGNFGEVFKGTLQR----DKTPV--AVKTCK-EDLPSELKIRFLSEARILKQY 605

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY--QAANGLAYI 239
           DH N+VK  GV    +P+Y++MEL  GG   S L K    +  K  L +   AA G+AY+
Sbjct: 606 DHPNIVKLIGVCTQRQPIYIVMELVPGGDFLSYLRKKKDELKTKQLLRFAVDAAAGMAYL 665

Query: 240 HEKNLMHRDVAARNCLYGGGQVL 262
             KN +HRD+AARNCL G    L
Sbjct: 666 ESKNCIHRDLAARNCLVGDNNAL 688


>UniRef50_O44570 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=O44570_CAEEL
          Length = 448

 Score =  146 bits (369), Expect = 6e-34,   Method: Compositional matrix adjust.
 Identities = 99/283 (34%), Positives = 152/283 (53%), Gaps = 43/283 (15%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGE---KRQFVLSVVG----- 52
           + +K L    +YHG  PRED+Q  L+  G FLLR SE V+GE    R+ +LS++      
Sbjct: 170 ILEKKLREFNFYHGFFPREDLQTTLHNLGDFLLRVSEVVEGEHKVNREVILSLIPVSTVS 229

Query: 53  ----EKK-----TSAN------HFVVRESDHKVYVDKI----------GFPTIIELVNHY 87
               EKK       AN      +F+   +   V + ++           F +I +L+N+Y
Sbjct: 230 RDEEEKKKVRRLIQANAPACCLYFLTYLAPRNVVIKRVRNLFFCEPPRTFESISDLLNYY 289

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
             TK       GT +  LK  + +Q WE  H DV + K LGEGAFG+V  G L K+ D  
Sbjct: 290 --TKNHGGCASGTFQ--LKHPILQQSWEFMHSDVTIGKVLGEGAFGKVCSGTL-KLKDGT 344

Query: 148 HQPVLVAVKTAKLES-MTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELA 206
           +  V VA+K  K+ + ++K +IKE+M EAR +RN +H NVV+ +GVA   +PLY+++EL 
Sbjct: 345 N--VDVAIKMTKVSAFLSKMKIKEMMNEARFIRNFNHKNVVRLYGVAHHEQPLYILLELV 402

Query: 207 DGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHR 247
            GG+L   + K      ++++ +    A  G+ Y+H+ N +HR
Sbjct: 403 KGGSLQDHMKKEKGAVSIVERIKFCRGAGRGIEYLHQNNCIHR 445


>UniRef50_A8QBK0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QBK0_BRUMA
          Length = 442

 Score =  144 bits (362), Expect = 4e-33,   Method: Compositional matrix adjust.
 Identities = 89/255 (34%), Positives = 140/255 (54%), Gaps = 12/255 (4%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           + +LL + YYHG++   D++++L + G FL     P + E+   V  V   +   A +  
Sbjct: 64  NDNLLSETYYHGIVNCVDVEKLLIRDGDFLFGI--PEEDEEESIVWVVRYNRDLWAFNIG 121

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           + E D   +V++  F  I E+V+ Y+ T++       T+  V+K+ V    W + H+ V 
Sbjct: 122 LTEKDL-YFVNQKCFKKISEMVSDYIRTRKPIHE---TLPIVVKRPVPHPAWVVSHDRVR 177

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L  +LGEGAFG V+KG    IL   H  + VA KT   ++  K +    ++EA++MR+  
Sbjct: 178 LKDELGEGAFGRVYKG----ILQVGHTYMTVAAKTCVGQASDKTKRASFLQEAKVMRDYK 233

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELIYQAANGLAYIH 240
           H N+V+F G+A   EPL +I+E   GG+L   L K   H  +  +Y    +A+ GL Y+ 
Sbjct: 234 HENLVQFIGIACQKEPLMIIVEFCGGGSLLKYLRKKGAHLGIATRYRFGKEASAGLKYLE 293

Query: 241 EKNLMHRDVAARNCL 255
           EK  +HRDVAARNCL
Sbjct: 294 EKRCIHRDVAARNCL 308


>UniRef50_P91360 Putative uncharacterized protein n=3 Tax=root RepID=P91360_CAEEL
          Length = 577

 Score =  142 bits (358), Expect = 1e-32,   Method: Compositional matrix adjust.
 Identities = 99/280 (35%), Positives = 151/280 (53%), Gaps = 41/280 (14%)

Query: 12  YHGLLPREDIQEMLNKPGQFLLRTSEP--------------------VKGEK----RQFV 47
           +HG + RED  ++L  PG +L+R S P                     KG K    + FV
Sbjct: 173 FHGYICREDAAQILKHPGDWLVRLSVPPSNDQDKKNKAQNLAKSVERTKGHKSTMQKVFV 232

Query: 48  LSVV------GEKKTSANHFVVRESDHKVYVDKIGF-PTIIELVNHYVSTKESFSTKDGT 100
           +SV+         K++  + V++ ++ K  +D + +   + +L +HY  T  S   K+G 
Sbjct: 233 ISVLCKGKALSPAKSNNRNLVIKTNNGKFSIDSVHWLVKLKDLFSHYQGT--SAVHKNGE 290

Query: 101 VKAVLKQAVERQKWELYHEDVEL-TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAK 159
            +  L   +   KWE  HED EL  KKLGEGAFGEV  G+L    D   + V VAVK  K
Sbjct: 291 FQ--LLNPISLSKWEFQHEDTELLAKKLGEGAFGEVRVGRLT-TKDPKKKLVEVAVKMLK 347

Query: 160 --LESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK 217
              +S+T++Q++E++ E R+MR LDH NV++ +GVA   EPLY+++EL   GAL   L +
Sbjct: 348 SSADSVTRDQVEELLHETRIMRKLDHPNVLRSYGVAVLREPLYLMIELCSNGALREYLKE 407

Query: 218 LH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
            H    +  K   +  +A G+AY+H + ++HRD+A RN L
Sbjct: 408 NHKTITLADKINFVLGSARGVAYLHSQRILHRDLAVRNIL 447


>UniRef50_O01798 Defective spermatogenesis protein 8 n=3 Tax=Caenorhabditis
           RepID=O01798_CAEEL
          Length = 512

 Score =  141 bits (356), Expect = 2e-32,   Method: Compositional matrix adjust.
 Identities = 90/256 (35%), Positives = 141/256 (55%), Gaps = 15/256 (5%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHK- 69
           +YHG + R + + ML+  G FL+R +E   G++  +V+S+  + K    H +V+ +  K 
Sbjct: 114 FYHGFMGRNECEAMLSNHGDFLIRMTEI--GKRVAYVISI--KWKYQNIHVLVKRTKTKK 169

Query: 70  -VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLG 128
             +  K  F +I EL+ ++    +     +G     L   + R  W+L +E V L KKLG
Sbjct: 170 LYWTKKYAFKSICELIAYHKRNHKPIY--EGMT---LICGLARHGWQLNNEQVTLNKKLG 224

Query: 129 EGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVK 188
           EG FGEV KG L   + A   PV VAVKT     ++  +    +REA +M  L H NV+K
Sbjct: 225 EGQFGEVHKGSLKTSVFA--APVTVAVKTLHQNHLSANEKILFLREANVMLTLSHPNVIK 282

Query: 189 FFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY--QAANGLAYIHEKNLMH 246
           F+GV    EP+ ++ME  DG +L+ AL      +  + +++Y   AA G+ Y+H K ++H
Sbjct: 283 FYGVCTMKEPIMIVMEFCDGKSLEDALLSKEEKVSAEDKILYLFHAACGIDYLHGKQVIH 342

Query: 247 RDVAARNCLYGGGQVL 262
           RD+AARNCL    ++L
Sbjct: 343 RDIAARNCLLNSKKIL 358


>UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=O01325_CAEEL
          Length = 474

 Score =  140 bits (353), Expect = 5e-32,   Method: Compositional matrix adjust.
 Identities = 95/251 (37%), Positives = 145/251 (57%), Gaps = 14/251 (5%)

Query: 9   QKYYHGLLPREDIQEMLNKPGQFLLRTSEPVK-GEKRQFVLSVVGEKKTSANHFVVRESD 67
           + +YHG + RE+ ++++   G+FLLR +E  K GE    VLSV  ++    +H VV +++
Sbjct: 89  EPFYHGYMSREESEKLVRSQGEFLLRKTELTKRGE--VVVLSVFWDE--GVHHLVVEKAN 144

Query: 68  HKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKK 126
           + +Y + +  F  I +LV ++  T+ S   K G     L   V R++W+LYHE + L KK
Sbjct: 145 NGLYYLKEFCFENISDLVRYHHQTRASV-YKSGIK---LFSWVVREEWQLYHEQINLGKK 200

Query: 127 LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINV 186
           LG G FGEV++G L   +  N   V VAVKT K   +T ++    +REA LM  L+H  V
Sbjct: 201 LGNGEFGEVFQGVLSVGIFTND--VEVAVKTMKGSKVTADERITFLREANLMLKLNHKYV 258

Query: 187 VKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNL 244
           V+ +GVA   EP+ ++MEL  GG L S + K       + K +   Q A G+ Y+ +K +
Sbjct: 259 VRLYGVATQQEPIMIVMELCSGGCLKSRIEKKDEQLSDVLKRKYCKQIAKGMRYLEKKQV 318

Query: 245 MHRDVAARNCL 255
           +HRD+AARN L
Sbjct: 319 IHRDLAARNVL 329


>UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia malayi
           RepID=A8Q5B5_BRUMA
          Length = 1138

 Score =  137 bits (345), Expect = 3e-31,   Method: Compositional matrix adjust.
 Identities = 94/267 (35%), Positives = 144/267 (53%), Gaps = 19/267 (7%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSV-VGEKKTSANHFV 62
           K+L  Q +YHGLL REDI+++L K G FL+R ++       Q VLS+ VGE+       V
Sbjct: 716 KELEDQHWYHGLLSREDIEKLLVKNGDFLVRVTD--NQGVHQIVLSIHVGERNIHLTIAV 773

Query: 63  VRESDHKVYVDKIG--FPTIIELVNHYVSTKESFSTKDGTVKAV-LKQAVERQKWELYHE 119
             +   ++ V + G  FP+I +LV +Y   K     KD + K + L   V + KW + HE
Sbjct: 774 TEDGHFQLSVLRRGPRFPSIYDLVQYYKMHK--IKIKDASGKDIRLGDGVPKPKWLVKHE 831

Query: 120 DVELTKK--------LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +   K         LG G F +V+ G      D N Q + VA+K  K E     + K+ 
Sbjct: 832 AINYDKNKACHLNLPLGSGNFADVYLGTFTCEKDGNKQIIPVAIKIIKPEKGGGREAKQS 891

Query: 172 M-REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI--KKYEL 228
           M RE ++M   +H N+V+F+GVA    P+ ++ME   GG+L++ L K    ++  ++ E 
Sbjct: 892 MIREGKIMSFYNHENIVQFYGVACDRPPIAIVMEYCPGGSLENHLKKQKENIVIGERIEY 951

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCL 255
             +AA G+ Y+H +  +HRD+AARNCL
Sbjct: 952 CLEAALGMRYLHMQGCLHRDLAARNCL 978


>UniRef50_A8XL41 Putative uncharacterized protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8XL41_CAEBR
          Length = 505

 Score =  136 bits (343), Expect = 6e-31,   Method: Compositional matrix adjust.
 Identities = 94/286 (32%), Positives = 143/286 (50%), Gaps = 45/286 (15%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF-VVR 64
           L+  ++YHG++PR +I  +L   G F +R +     E+ + ++ +  + +    HF +V 
Sbjct: 70  LIEHRWYHGVMPRGEISTLLEDEGDFCVRKTT----ERGKPIVCISVKCQKEVRHFPLVF 125

Query: 65  ESDH---KVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDV 121
           E+     K  +    F  ++EL+N  V+ K + S       A+L +AV R  + + H D+
Sbjct: 126 ENGQWTLKNLIKTRRFYEVVELLNALVTEKIALSG------AILVRAVPRPDYYIPHSDI 179

Query: 122 ELTKKLGEGAFGEVWKGKLLK--------------------------ILDANHQP----V 151
            L  KLGEGAFGEVWKG L +                           L  N +     +
Sbjct: 180 SLICKLGEGAFGEVWKGSLKRHEDGKAKKAEEKSAAPSSAAPSSAGSALSGNSEKGKSRL 239

Query: 152 LVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGAL 211
            VAVK  K  + TK   +E + EA+LMR L H N+V  +GVA   EPL +++ELA  G L
Sbjct: 240 YVAVKKMK-GNATKAMTEEFVMEAKLMRQLVHPNIVTVYGVAPSEEPLMIVLELAGNGCL 298

Query: 212 DSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
            S + K   P  +  +    AA G+AY+  K ++HRD+AARN L G
Sbjct: 299 KSYVAKYQCPPDQLLQFTADAARGMAYLSSKLVIHRDLAARNLLLG 344


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score =  135 bits (339), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 93/288 (32%), Positives = 146/288 (50%), Gaps = 51/288 (17%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           ++ L  Q +YHG +PR ++Q++L K G FL+R S+    EK  +VLSV      +  HF+
Sbjct: 520 ERPLEQQTWYHGAIPRLEVQQLLTKDGDFLVRKSQ----EKPGYVLSV--HWSGACKHFL 573

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           V+  D+   +D   F TI +L+  Y ++++  + K    + VL++ V + KW L H+D+ 
Sbjct: 574 VQNKDNMYCLDGESFHTIPQLIQQYQTSQQHVTKKS---EVVLRRPVLKDKWVLEHDDII 630

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA------- 175
           L   +G G FGEV+KG+    L  ++ P  VAVKT K  ++  EQ  + + EA       
Sbjct: 631 LGHIIGRGNFGEVYKGQ----LRPDNTP--VAVKTCK-NNLPLEQKSKFLIEARSAHTHT 683

Query: 176 -------------------------RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGA 210
                                    R+++  DH NVVK  GV    +P+Y++MEL  G  
Sbjct: 684 HTHTHTHTHTHAHAHAALYSHPTLSRILKQYDHPNVVKLIGVCTQKQPIYIVMELIQGSG 743

Query: 211 LDSALGKLHFPMIKKYELIYQA---ANGLAYIHEKNLMHRDVAARNCL 255
                 +     +K   L+  A   A+G+AY+  K  +HRD+AARNCL
Sbjct: 744 DFLTFLRNQGRDLKPKALVKMAENVASGMAYLESKKCIHRDLAARNCL 791


>UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes related) tyrosine kinase
           (phosphoprotein NCP94), partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E47E92
          Length = 527

 Score =  134 bits (336), Expect = 4e-30,   Method: Compositional matrix adjust.
 Identities = 84/266 (31%), Positives = 150/266 (56%), Gaps = 20/266 (7%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           T+  L  +++YHG LPR++ + +L   G F++R      G   ++VLS   +  +   HF
Sbjct: 198 TELRLEEEEFYHGALPRKETEALLVNDGDFVVREKSDAWG---RYVLS--AKHASKVRHF 252

Query: 62  VVRESDHKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWE--LYH 118
            ++ +D  +Y ++   F T+ EL+   +++++  +      +A+L + V R + E  L H
Sbjct: 253 PIQINDENMYRLEGDAFQTVGELIRFQLNSRQPVTK---ASQAILLKPVCRVRNEHDLRH 309

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           E+++L +KLG G FG+V +G++ +        + VAVKT K E++     ++ ++EA ++
Sbjct: 310 EEIDLEEKLGAGHFGDVHRGRIKRTQ------LAVAVKTCK-ETVDAATRRKFLQEANIL 362

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGL 236
           +  DH N+VK  GV     P+Y++MEL  GG L S L   +      ++ ++   AA+G+
Sbjct: 363 KQYDHANIVKLIGVCTDKHPIYIVMELVPGGDLLSFLRTDQNELSTKQRVKMGEDAASGM 422

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQVL 262
           AY+  K  +HRD+AARNCL G   V+
Sbjct: 423 AYLESKQCIHRDLAARNCLVGNKNVI 448


>UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y1_9METZ
          Length = 893

 Score =  133 bits (335), Expect = 6e-30,   Method: Compositional matrix adjust.
 Identities = 83/265 (31%), Positives = 146/265 (55%), Gaps = 31/265 (11%)

Query: 9   QKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVV--GEKKTSANHFVVRES 66
           +++++  + R++ +E     G +L+R S     ++ ++VL+V   G+ K    HFV++E+
Sbjct: 524 ERWFYPNMERKEAEEKCKNTGDYLIRYS----SKQNRYVLTVCWAGQGK----HFVIQEA 575

Query: 67  DH-----KVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ--KWELYHE 119
                  K   +   FP++ EL++ +V+++   +   G   A+L + + R+  KW L HE
Sbjct: 576 PDEQTKTKYRFESRSFPSVRELLDFHVNSQTPVTKASG---AILSRPILREDDKWALKHE 632

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           D+++ +KLG+GAFG+VW+  L            VAVKT +   +   +  + ++EA +++
Sbjct: 633 DIKMGRKLGKGAFGDVWEAAL-------KGQGKVAVKTCRSTDVPDRE--KFLQEAEILK 683

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK--YELIYQAANGLA 237
             DH N+VK  GV+  TEP+ ++MEL  GG+L   L K    M K     +   A  G+ 
Sbjct: 684 QYDHPNIVKLIGVSWDTEPVLIVMELMPGGSLLDYLRKKAAQMTKGKLLHMSIDACGGME 743

Query: 238 YIHEKNLMHRDVAARNCLYGGGQVL 262
           Y+  KN +HRD+AARNCL G   ++
Sbjct: 744 YLESKNCIHRDLAARNCLVGENDIV 768


>UniRef50_A8QEG4 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QEG4_BRUMA
          Length = 392

 Score =  132 bits (332), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 85/261 (32%), Positives = 127/261 (48%), Gaps = 38/261 (14%)

Query: 12  YHGLLPREDIQEMLNKPGQFLLRTSEPVKGEK-------------RQFVLSVVGEKKTSA 58
           +HG++P ED   +L   G FL+R  E  +G K              + V  + G  K   
Sbjct: 29  WHGMIPDEDTAMLLKNSGDFLMRAVEHDRGYKITLSIRWGNEVVNSEIVPGIQGGYKFQG 88

Query: 59  NHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
            HF   +                +L++ Y  TK   +    ++   L+  + RQ WEL H
Sbjct: 89  KHFCQTK----------------DLIDSYQVTKRPLTVN--SIVVTLEIPIRRQHWELQH 130

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           + + L KK+G G+FG V+KG    I     + + VAVK  +L  +T E    + REAR+M
Sbjct: 131 KMIRLGKKIGSGSFGTVYKGA---ITIGIKKSITVAVK--ELTEITAEASNALWREARVM 185

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYELIYQAANGL 236
           R  DH NVVK++GVA    P Y++ME   GGA+D  L           + +++ +AA GL
Sbjct: 186 RMYDHPNVVKYYGVANDYTPYYLVMEFVSGGAVDEYLCKKGKKIAAKARVKILQEAAIGL 245

Query: 237 AYIHEKNLMHRDVAARNCLYG 257
            Y+H +  +HRD+A RN L G
Sbjct: 246 EYLHRQKCLHRDIACRNLLIG 266


>UniRef50_A8XFQ1 Putative uncharacterized protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8XFQ1_CAEBR
          Length = 643

 Score =  131 bits (330), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 93/282 (32%), Positives = 148/282 (52%), Gaps = 44/282 (15%)

Query: 12  YHGLLPREDIQEMLNKPGQFLLRTS-EPVKGEKRQ------------------------- 45
           +HG + RED+  +L   G +L+R S +P K  +++                         
Sbjct: 224 FHGYICREDVTILLKNSGDWLVRLSVQPCKENEKKASKGAKSVERGSKARGSKNRSKDNN 283

Query: 46  --FVLSV-----VGEKKTSANHFVVRESDHKVYVDKIG-FPTIIELVNHYVSTKESFSTK 97
             FV+SV     V   K+S  + V++ +D K  +D I  F  + +  ++Y  T  ++   
Sbjct: 284 KVFVISVHSRKAVSPGKSSCRNLVIKTNDGKFSIDSIKWFMKVADFFSYYQGTVATYKES 343

Query: 98  DGTVKAVLKQAVERQKWELYHEDVEL-TKKLGEGAFGEVWKGKL-LKILDANHQPVLVAV 155
           +  +      +V    WE + +D+EL +KKLGEGAFG+V  G++  K        V VAV
Sbjct: 344 EFQLLHPCHLSV----WEFHQDDIELMSKKLGEGAFGDVRVGRMTTKDPKKTVAVVDVAV 399

Query: 156 KTAK--LESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDS 213
           K  K  LES+T++Q+ E++ EAR+MR LDH NV++ +GV+   EPLY++ EL   GAL  
Sbjct: 400 KMLKNSLESITRDQVDELLHEARVMRRLDHPNVLRTYGVSVLREPLYLMNELCANGALRE 459

Query: 214 ALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARN 253
            L + H    +  K   +  AA G+AY+H + ++HRD+A RN
Sbjct: 460 YLKENHKTITISDKLNFVLGAARGVAYLHSQRIIHRDLAVRN 501


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  131 bits (329), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 93/275 (33%), Positives = 141/275 (51%), Gaps = 39/275 (14%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
           D+ L  + ++ G + R D ++ L    NK G FL+R SE  KGE   F LSV+       
Sbjct: 108 DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGE---FSLSVL--DGAVV 162

Query: 59  NHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER----- 111
            H+ ++  D   +    +  F T+ E V+HY  T +    K G  K  LK  V       
Sbjct: 163 KHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLG--KPCLKIQVPAPFDLS 220

Query: 112 ----QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
                +WE+    ++L K+LG G FGEVW+G     L  N  PV  AVKT K  SM    
Sbjct: 221 YKTVDQWEIDRNSIQLLKRLGSGQFGEVWEG-----LWNNTTPV--AVKTLKPGSMDP-- 271

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL-----GKLHFPM 222
             + +REA++M+NL H  +++ + V    +P+Y+I EL   G+L   L      K+H  +
Sbjct: 272 -NDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIH--L 328

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
            ++ ++  Q A+G+AY+  +N +HRD+AARN L G
Sbjct: 329 TQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVG 363


>UniRef50_A8Q7I8 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q7I8_BRUMA
          Length = 375

 Score =  131 bits (329), Expect = 3e-29,   Method: Compositional matrix adjust.
 Identities = 92/258 (35%), Positives = 140/258 (54%), Gaps = 30/258 (11%)

Query: 7   LHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKK----TSANHFV 62
           L + +YHG LP  DI  +L + G F++R     K +K    LS +   K    ++ N+F 
Sbjct: 11  LQRTFYHGFLPHADIDPLLKEEGDFVIR-----KTDKDGNHLSKIYNWKIIFQSAQNNFF 65

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
                + +  +K    T+ +L+N + +T    S       A L   V RQ W L H++++
Sbjct: 66  CSCYFYCLQDEK----TMHDLINWHKTTGTPISAGS---HAKLVNGVGRQPWLLEHDEIQ 118

Query: 123 LTKKLGEGAFGEVWKGKLL---KILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           L +KLGEGAFGEV+  + +   KI D       VAVKT + E+  + ++K  M+EAR+MR
Sbjct: 119 LQRKLGEGAFGEVYLAQYVQMNKITD-------VAVKTMREEASRQARLK-FMKEARIMR 170

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK--KYELIYQAANGLA 237
              H NVVK  G+     PL ++MEL   G++ S L K + P+    K   + +A+ GLA
Sbjct: 171 KFSHPNVVKIMGIVVYENPLMIVMELCPEGSMLSYLRK-NVPVNSDLKLRFVTEASAGLA 229

Query: 238 YIHEKNLMHRDVAARNCL 255
           Y+  K+ +HRD+AARNCL
Sbjct: 230 YLESKHCIHRDIAARNCL 247


>UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76978_9METZ
          Length = 879

 Score =  131 bits (329), Expect = 3e-29,   Method: Compositional matrix adjust.
 Identities = 82/263 (31%), Positives = 146/263 (55%), Gaps = 30/263 (11%)

Query: 9   QKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDH 68
           + +YHG + R++   +L K G FL+R S     +K  + L+V   K     HF+++ ++ 
Sbjct: 515 EPWYHGEISRQEATGLLKKMGDFLVRYS----ADKEHYTLTV---KMEGIKHFIIQHNEE 567

Query: 69  KVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER---QKWELYHEDVELTK 125
               +   +P+I  L++H+   +   + K    +A+L+Q V++   +++ + H+++ + +
Sbjct: 568 GFRFEGDPYPSIPMLIDHHFKNRLPVTRKS---QAILRQPVKKPDLREYNISHDNILIGE 624

Query: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
           K+G+G FG+V+KG L       H  + VAVK+ + E    +Q  + ++EA +++   H N
Sbjct: 625 KIGKGNFGDVFKGYL-----KTHN-MEVAVKSCRSEDFPDKQ--KFLQEAEILKQYRHPN 676

Query: 186 VVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKY------ELIYQAANGLAYI 239
           +V+  GV A  EPLY+IMEL  GG     L  L  P  K+       E+  +AA G+ ++
Sbjct: 677 IVELIGVCAEKEPLYIIMELMAGGNF---LSFLRGPEGKRLKVNNLTEMCVEAAAGMVFL 733

Query: 240 HEKNLMHRDVAARNCLYGGGQVL 262
            ++N +HRD+AARNCL G   VL
Sbjct: 734 EQRNCIHRDLAARNCLVGDNNVL 756


>UniRef50_Q19726 Protein F22D6.1, partially confirmed by transcript evidence n=5
           Tax=root RepID=Q19726_CAEEL
          Length = 418

 Score =  130 bits (326), Expect = 6e-29,   Method: Compositional matrix adjust.
 Identities = 93/261 (35%), Positives = 140/261 (53%), Gaps = 24/261 (9%)

Query: 8   HQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESD 67
           + +++HG+L R+D  E+L KPG FLLR SE V G K   +LSV  + K   N  V  ++ 
Sbjct: 27  NNEWFHGVLQRQDADELLVKPGSFLLRASE-VHG-KMSMILSVRHDGKLH-NIAVNSDTG 83

Query: 68  HKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKL 127
              + +     +I +LV  +++T     TK   VK  LK  + +  W + HE+V   KKL
Sbjct: 84  ENFWFEGHREKSIDQLVQWHMTTSTPI-TKTSGVK--LKYPIGKADWIISHENVIFIKKL 140

Query: 128 GEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVV 187
           GEGAFGEV     L   +   + V  AVKT + + MT++     M+EARLMR   H ++V
Sbjct: 141 GEGAFGEV----SLAECEIGGRKVETAVKTMRCQ-MTRDTRAAFMKEARLMRKYSHPHIV 195

Query: 188 KFF-----------GVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAAN 234
           +             G+A    PL ++ME+   G+L S L   K    + ++     ++A+
Sbjct: 196 RIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHGSLLSFLRKNKGKTTLSERLRFCIESAD 255

Query: 235 GLAYIHEKNLMHRDVAARNCL 255
           GLAY+ +K  +HRD+AARNCL
Sbjct: 256 GLAYLEKKQCLHRDIAARNCL 276


>UniRef50_Q7YSY1 Fes-like tyrosine kinase protein n=5 Tax=Schistosoma mansoni
            RepID=Q7YSY1_SCHMA
          Length = 1259

 Score =  128 bits (321), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 81/293 (27%), Positives = 143/293 (48%), Gaps = 52/293 (17%)

Query: 1    MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEP---------------------- 38
            + D D+  + ++HG+LPR +++ +L   G FL+R +                        
Sbjct: 811  ICDMDINKEPWFHGVLPRAEVERLLQNQGDFLVRQTSKRSSGRDTIGHWNGTNGDLINGN 870

Query: 39   -----------VKGEKRQFVLSVVGEKKTSANHFVVR---ESDHKVYVDKIGFPTIIELV 84
                       + G   + VLSV         HF++    E+    +++   F TI EL+
Sbjct: 871  HNETILNKDHNMDGTVLRMVLSVFWH---GHRHFILYGGPETGEGWHLEDGHFSTIRELI 927

Query: 85   NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKIL 144
             +++ T+   + K G   A L   + R  WEL + DV+L +K+G+G FG+V++G      
Sbjct: 928  EYHMKTQTPVTAKSG---ACLVTPISRPDWELDNRDVQLLQKIGQGNFGDVYRGV----- 979

Query: 145  DANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIME 204
               +    VAVKT +++    +  ++ ++      N +H N+VK  G+A  + P+ ++ME
Sbjct: 980  ---YNGCEVAVKTCRVDMTASDLRRKFLQGETTALNFNHPNIVKLVGIAVQSYPIMIVME 1036

Query: 205  LADGGALDSAL--GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
               GG+L + L   K   P++K  ++   AANG+ Y+  +N +HRD+AARNCL
Sbjct: 1037 YVPGGSLLNHLRKSKNALPVMKLLQMSLDAANGMMYLEARNCIHRDLAARNCL 1089


>UniRef50_Q8I4A8 Protein ZK20.2, partially confirmed by transcript evidence n=2
           Tax=Caenorhabditis elegans RepID=Q8I4A8_CAEEL
          Length = 365

 Score =  128 bits (321), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 83/223 (37%), Positives = 130/223 (58%), Gaps = 28/223 (12%)

Query: 44  RQFVLSVVGEKKTSA------NHFVVRE--SDHKVY-VDKIGFPTIIELVNHYVSTKESF 94
           R ++LSV      S       N  +++E   + K+Y +    F +I ++VNHY++TKE  
Sbjct: 7   RHYILSVKHNSPPSPDLVPIINMVIMQEVVCNRKMYSIQCKCFESIQQMVNHYLTTKELI 66

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           S+   +  A L +AV RQ WEL H+++ + ++L +GAF E+  G+L K  ++    + VA
Sbjct: 67  SSIYSS--AHLIKAVPRQHWELDHKNIFIQQRLRDGAFEEIMMGQL-KCRNSGKM-IHVA 122

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           +K  K+ ++TK+QIKE M+EAR+M                 TEPLY++ ELA  G LD+ 
Sbjct: 123 IKKTKMRNLTKDQIKEFMQEARVM---------------PTTEPLYIVTELAFHGPLDNY 167

Query: 215 LGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
           L K    + +K E+  QAA G+ Y+H K ++HRD+AARN +YG
Sbjct: 168 LKKNELSIDRKNEMTLQAAWGIEYLHSKPVIHRDIAARNFVYG 210


>UniRef50_Q21764 Protein R05H5.4, partially confirmed by transcript evidence n=6
           Tax=Caenorhabditis RepID=Q21764_CAEEL
          Length = 414

 Score =  127 bits (320), Expect = 3e-28,   Method: Compositional matrix adjust.
 Identities = 82/255 (32%), Positives = 135/255 (52%), Gaps = 18/255 (7%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKV 70
           Y+HG L   D  ++L   G F++   + +   K Q  L+V    K     + ++ +    
Sbjct: 16  YFHGALMNIDADQLLVNEGDFMVTMKKQLDINKLQLFLAV--RLKKGIRRYEIKRTSKTA 73

Query: 71  YVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEG 130
            +       I++L+N   +       +    K VLK+A+ + K++L H+DV   KK+G G
Sbjct: 74  KIGGKTSQNIVKLINMLKADPIEIRGE----KVVLKRAIPKGKFQLMHKDVIFQKKIGAG 129

Query: 131 AFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFF 190
           A+G V++GKL+K  +      ++AVK    E   ++ + E+M+EAR+M+  DH N+VKF 
Sbjct: 130 AYGTVYRGKLVKTDE------VIAVKKLDPEGADEDGLAEMMKEARVMQLYDHPNIVKFH 183

Query: 191 GVAAGTEPLYVIMELADGGALDSALG----KLHFPMIKKYELIYQAANGLAYIHEKNLMH 246
           G      P  +++E  +GGA++  L     K+  P   KY   Y AA G+ Y+H+KN +H
Sbjct: 184 GFILDDLPYLLVLEYCNGGAVEDRLRDKGEKIKVPTRVKY--TYMAACGMDYLHKKNCIH 241

Query: 247 RDVAARNCLYGGGQV 261
           RD+A+RNCL   G V
Sbjct: 242 RDIASRNCLIHKGVV 256


>UniRef50_A8P3F9 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P3F9_BRUMA
          Length = 441

 Score =  121 bits (303), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 78/253 (30%), Positives = 137/253 (54%), Gaps = 13/253 (5%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKV 70
           ++HG L  +D+ ++L   G FLL+T      +K + +L++    +T        E  +++
Sbjct: 9   FFHGALLDDDVDKLLELNGDFLLQTKFEQSKKKNKLILAIRHGHRTIRIPISRLEKGYRI 68

Query: 71  YVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEG 130
           +     F T+  L+ +Y   +E      G    +L++ +++ ++EL H D+++ KK+G G
Sbjct: 69  FGR--SFSTMNTLIKYY---QEHNIEAHGIDSLLLRRPIKKGRFELNHSDIKIMKKIGYG 123

Query: 131 AFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFF 190
           A+G V+KG LLK L        VA+K       +++ + ++M+EAR+M+  DHINVVKF+
Sbjct: 124 AYGTVYKGILLKNL------CPVAIKRIDCADKSEQALIDLMKEARVMQLYDHINVVKFY 177

Query: 191 GVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRD 248
           G     EP  ++ME    G+++  L +      +  + ++  Q A GL Y+H K  +HRD
Sbjct: 178 GFIVDREPFLLVMEYCKDGSVEDKLRQYGRRLSIESRIDIACQIARGLEYLHLKGCIHRD 237

Query: 249 VAARNCLYGGGQV 261
           +A RNCL  G  V
Sbjct: 238 IATRNCLLNGAVV 250


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score =  120 bits (302), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 80/260 (30%), Positives = 130/260 (50%), Gaps = 25/260 (9%)

Query: 9   QKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVR 64
           +++++  + R+D +  L    NKPG +L+R SE  KG     +  V  + +    H+ +R
Sbjct: 125 EEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVVKHYKIR 184

Query: 65  ESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTK--DGTVKAVLKQAVERQKWELYHED 120
             D+  Y    KI F  I  ++ HY    +    K      K   ++  ++  WE+  + 
Sbjct: 185 SLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKAQKPWDKDAWEISKDS 244

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           +++ KKLG G FGEVW       +   +    VAVKT K  +M+   ++  + EA LM+ 
Sbjct: 245 IKMVKKLGAGQFGEVW-------MAFYNNSTKVAVKTLKPGTMS---VEAFLEEANLMKT 294

Query: 181 LDHINVVKFFGVAAGTEPLYVIME-LADGGALD----SALGKLHFPMIKKYELIYQAANG 235
           L H  +V+ + V   TEP+Y+I E +A+G  LD     A  K+  P +  +    Q A G
Sbjct: 295 LQHDRLVRLYAVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSA--QIAEG 352

Query: 236 LAYIHEKNLMHRDVAARNCL 255
           +AYI +KN +HRD+ A N L
Sbjct: 353 MAYIEKKNYIHRDLRAANVL 372


>UniRef50_Q23102 Protein W01B6.5, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q23102_CAEEL
          Length = 536

 Score =  119 bits (298), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 92/300 (30%), Positives = 145/300 (48%), Gaps = 62/300 (20%)

Query: 12  YHGLLPREDIQEMLNKPGQFLLRTS-EPVKGE---------------------------- 42
           +HG + RED+  +L   G FL+RTS +P K E                            
Sbjct: 110 FHGFIGREDLMSVLKNVGDFLIRTSVQPNKHEVEKMKKNQADVKVLGNLSREKCAKKEKE 169

Query: 43  ------------KRQFVLSVVGEKK----------TSANHFVVRESDHKVYVDKI-GFPT 79
                       +R+FV+SV  + K          T   + V++  +  V+V+ +  F T
Sbjct: 170 KEEKLAGMGDVGRREFVISVYCKDKEKPATDKPQYTPIRNLVIKRDNGMVHVEPLRKFKT 229

Query: 80  IIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT-KKLGEGAFGEVWKG 138
           + E   +Y   K S   K+   + +    +    WE  HED+ L  KKLGEGAFGEV  G
Sbjct: 230 LTEFFGYY--QKNSGICKETDFQLIT--PIPLSNWEFIHEDIALQQKKLGEGAFGEVRIG 285

Query: 139 KLLKILDANHQPVLVAVKTAK-LESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE 197
           K+   L +  + V VAVK  +  E + +EQ+ E++ EAR+MR +DH NV++ +G+A   E
Sbjct: 286 KMK--LKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMMDHKNVLRSYGIAVLKE 343

Query: 198 PLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
           PLY++ E+   GAL   L   +    + +K   +  ++ G+ Y+H +  +HRD+A RN L
Sbjct: 344 PLYLMTEMCACGALREYLRENQETVTLAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNIL 403


>UniRef50_A8WPD7 Putative uncharacterized protein n=4 Tax=Caenorhabditis
           RepID=A8WPD7_CAEBR
          Length = 423

 Score =  118 bits (295), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 82/259 (31%), Positives = 134/259 (51%), Gaps = 22/259 (8%)

Query: 7   LHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
           L+  Y+HG L  +D  ++L   G F++     +   K      +V   K     + ++  
Sbjct: 11  LNLPYFHGALMNQDADQLLVNDGDFMVTMKLQIDINK------LVVRLKKGIRRYEIKRL 64

Query: 67  DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKK 126
                +      TI +L+N   S K       G  K VLK+A+ + K++L H+DV   KK
Sbjct: 65  PGSAKLGSRSKETIDKLIN---SLKTDVLEIKGE-KIVLKRAIAKGKFQLMHKDVIFKKK 120

Query: 127 LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINV 186
           +G GA+G V++G+L+K  +      ++AVK    ES  ++ + E+M+EAR+M+  DH N+
Sbjct: 121 IGAGAYGTVYRGRLVKTNE------VIAVKKLDPESADEDGLAEMMKEARVMQLYDHPNI 174

Query: 187 VKFFGVAAGTEPLYVIMELADGGALDSAL----GKLHFPMIKKYELIYQAANGLAYIHEK 242
           VKF G      P  +++E  +GG+++  L     +L  P    Y   Y AA G+ Y+H+K
Sbjct: 175 VKFHGFILDDLPYLLVLEFCNGGSVEDRLRDKGSRLTVPTRVHY--TYMAACGMDYLHKK 232

Query: 243 NLMHRDVAARNCLYGGGQV 261
             +HRD+A+RNCL   G V
Sbjct: 233 GCIHRDIASRNCLIHRGIV 251


>UniRef50_A8XI09 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8XI09_CAEBR
          Length = 468

 Score =  117 bits (293), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 87/242 (35%), Positives = 126/242 (52%), Gaps = 29/242 (11%)

Query: 29  GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIGF-PTIIELVNHY 87
           G +LLR +EP +G   QF+  V+  K+      V    D +  + +  F PT        
Sbjct: 66  GDYLLRRAEPTEGIGGQFL--VISVKREGGFVHVPLSQDREGPLKQFYFMPT-------- 115

Query: 88  VSTKESFSTKDG----------TVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWK 137
           V      S  DG          T  A L++ V R  W + HEDV L KK+G GAFGEV+ 
Sbjct: 116 VKDTSVLSVIDGHLARGLPICITWNAYLRKPVNRSTWLIAHEDVILYKKIGSGAFGEVF- 174

Query: 138 GKLLKILDANHQPVL-VAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAG 195
             L +++D   + VL  AVK  K+E+    +++  M+EAR+MR    H +VV  FG+A  
Sbjct: 175 --LARMVDPTSEYVLDCAVKKLKMEATMDAKLR-FMKEARMMRKCYKHKHVVMIFGIATL 231

Query: 196 TEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARN 253
             PL ++MEL   G+L S L   K    ++ K     +A++GLA++ + N +HRDVAARN
Sbjct: 232 NSPLLILMELCPNGSLVSHLRKNKGKVTVLDKLRFSAEASSGLAHLEKMNCIHRDVAARN 291

Query: 254 CL 255
           CL
Sbjct: 292 CL 293


>UniRef50_Q21292 Protein K07F5.4a, partially confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q21292_CAEEL
          Length = 517

 Score =  117 bits (292), Expect = 5e-25,   Method: Compositional matrix adjust.
 Identities = 84/273 (30%), Positives = 134/273 (49%), Gaps = 38/273 (13%)

Query: 10  KYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSV---VGEKKTSANHFVV 63
           K YHG+  R+  ++ L    +PG FL R+     G      LSV    G+   + +H+ V
Sbjct: 28  KCYHGVRRRKKSRKNLMRGERPGTFLFRSCFVKSGVALALFLSVKVRAGDSDANIHHYQV 87

Query: 64  RESDHKVYV-------------DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE 110
            +   + Y+             +   FPT+ EL+ H+   + +        K  L + ++
Sbjct: 88  EDRAGEYYLMQELMEKEELVTRESKAFPTLEELIGHFQHHRLA-------CKIRLGRPLK 140

Query: 111 RQKWELYHEDV--ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
           R  W+L H  V  + T KLG G F  V++G L K      + + VA+K +K        +
Sbjct: 141 RPSWQLRHNSVVYDDTGKLGSGNFCIVYRGMLRK----QGKIIPVAIKVSKNSDKESAAL 196

Query: 169 KE----IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPM-- 222
            E    ++ EAR+M N ++INV++ +GVA    P  V ME   GG+L+ AL K    M  
Sbjct: 197 METRNLLLAEARIMMNYNNINVIRIYGVACDVPPFMVCMEFCSGGSLEDALKKYGKDMEE 256

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
            ++  L+  AA G+ Y+H+K  +HRD+A+RNCL
Sbjct: 257 FERQILLIDAARGMRYLHDKKCVHRDLASRNCL 289


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  116 bits (290), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 79/267 (29%), Positives = 138/267 (51%), Gaps = 34/267 (12%)

Query: 11  YYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
           +Y+G + R   +++L    NK G FL+R SE       ++ +S   E K    HF ++ S
Sbjct: 250 WYYGNINRVKAEKLLLASQNKDGSFLVRISE---SHSDEYTISARSEGKVF--HFRIQRS 304

Query: 67  DHKVYV--DKIGFPTIIELVNHY--------VSTKESFSTKDGTVKAVL---KQAVERQK 113
               Y   D+I F T+ EL+++Y        V  +E  + +     ++L   ++  + + 
Sbjct: 305 SIGAYFVSDRISFATLGELISYYQRNNRSLGVLLEEPCAQQRPLTPSLLCLQRELFDMEP 364

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE   E+  L +KLGEG FGEVW+         + +   VA+KT K E   ++   E ++
Sbjct: 365 WERPREEFRLLRKLGEGHFGEVWEALW------STENRRVAIKTLKQEDTKQD---EFVK 415

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY--- 230
           E + +++L H  +++   + +  EP+Y++ EL   G+L + L      ++    LIY   
Sbjct: 416 EVQALKSLHHPKLIQLLAMCSRGEPVYIVTELMTKGSLKAYLASAEGQVLTSAHLIYMGS 475

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYG 257
           Q A G+AY+ ++N++HRD+AARN L G
Sbjct: 476 QIAEGMAYLEDRNIVHRDLAARNILVG 502



 Score = 75.5 bits (184), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 69/246 (28%), Positives = 117/246 (47%), Gaps = 31/246 (12%)

Query: 26  NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIG--FPTIIEL 83
           N  G FL+R SE    +   +VLSV         H+ V ++D   +  + G  F ++ EL
Sbjct: 733 NSEGAFLIRVSEK---DNVGYVLSV--RSGDQVKHYKVLQTDQNRFYVEPGRRFSSLAEL 787

Query: 84  VNHYVSTKESFS------TKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWK 137
           V++Y  T  + +       K  T+            WEL  ++ EL ++LG G F  V++
Sbjct: 788 VDYYQKTSLNNAGPLGNPCKRNTLSTPALLPFPTIGWELPKKEFELEEELGSGCFARVYR 847

Query: 138 GKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE 197
           G+   +       + VAVK  K +S       +   E ++++NL H +++  F V   + 
Sbjct: 848 GRWKNL-------IRVAVKILKSDSELNH--GDFQTEVQILKNLRHRHLLSLFAVCTESR 898

Query: 198 PLYVIMELADGGALDSALGKLHFP------MIKKYELIYQAANGLAYIHEKNLMHRDVAA 251
           P ++I EL + G+L   L  L  P      +    ++  Q A+G++Y+ E+  +HRD+AA
Sbjct: 899 PYWIITELMEKGSL---LIFLRSPEGQNQDVASLIDMGTQVADGMSYLEEQKSIHRDLAA 955

Query: 252 RNCLYG 257
           RN L G
Sbjct: 956 RNVLVG 961


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score =  115 bits (289), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 83/269 (30%), Positives = 138/269 (51%), Gaps = 29/269 (10%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS 57
           + + L  Q +Y   + R   Q++L    N+PG FL+R SE   G    + LSV  + K  
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLG---GYSLSVRAQAKV- 166

Query: 58  ANHFVVRESDHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-WE 115
            ++ V   +D  +Y+ K   FP + EL+ +Y +  +    ++  ++  + Q   RQ  WE
Sbjct: 167 CHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLI--QNPLLQPCMPQKAPRQDVWE 224

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
             H +  L +KLGEG FGEVW+G  L  L        VA+K  K  +M   ++ ++ +E 
Sbjct: 225 RPHSEFALGRKLGEGYFGEVWEGLWLGSLP-------VAIKVIKSANM---KLTDLAKEI 274

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK-----LHFPMIKKYELIY 230
           + ++ L H  +++   V +G EP+Y++ EL   G L + LG      L  P +  +    
Sbjct: 275 QTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFAC-- 332

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGG 259
           Q A G++Y+ E+ ++HRD+AARN L   G
Sbjct: 333 QVAEGMSYLEEQRVVHRDLAARNVLVDDG 361


>UniRef50_Q9U2T8 Protein Y116A8C.38, partially confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=Q9U2T8_CAEEL
          Length = 528

 Score =  114 bits (286), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 80/265 (30%), Positives = 138/265 (52%), Gaps = 34/265 (12%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKV 70
           YYHG++ R+ ++  L + G +L+R ++    E  +F+LS   +K+  + H  ++  D + 
Sbjct: 70  YYHGMVARDLVESKLTRCGDYLIRATDNRIME-FEFILSFFNKKRIHS-HLTIK-CDVEA 126

Query: 71  YVDKIG------FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT 124
               +G      F ++++L N Y        T        LK+A+ + K+ + H+ ++ +
Sbjct: 127 GKWALGLLSVNQFSSVVDLTNFY-------KTNPIGAGFFLKRAISKGKYMIAHDRIKYS 179

Query: 125 KK---LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK---------EIM 172
            K   LG G F +V++GK+    +  +Q V VA+KT KL   T +  K         E++
Sbjct: 180 PKDDLLGTGNFSDVFRGKI----ELENQMVNVALKTTKLLDDTMDPTKNVKANKIKKEMI 235

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIY 230
           +EA +M  L H NV  FFG+A    P+ +I+E  +GG L   L K        +++  ++
Sbjct: 236 QEAEVMSQLRHANVTSFFGIAVDRLPILLIIEFCNGGNLQGHLIKFGDRIGTNERFLYLH 295

Query: 231 QAANGLAYIHEKNLMHRDVAARNCL 255
            A+ GL YIH  ++ HRD+AARNCL
Sbjct: 296 DASAGLNYIHAMSITHRDIAARNCL 320


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  112 bits (280), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 82/271 (30%), Positives = 133/271 (49%), Gaps = 39/271 (14%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+ +
Sbjct: 122 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHYRI 176

Query: 64  RE-SDHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-------- 113
              SD K+YV     F T+ ELV+H+ +        DG +  +   A +R K        
Sbjct: 177 NTASDGKLYVSSESRFNTLAELVHHHSTVA------DGLITTLHYPAPKRNKPTVYGVSP 230

Query: 114 ----WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
               WE+   D+ +  KLG G +GEV++G   K        + VAVKT K ++M   +++
Sbjct: 231 NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKY------SLTVAVKTLKEDTM---EVE 281

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELI 229
           E ++EA +M+ + H N+V+  GV     P Y+I E    G L   L + +   +    L+
Sbjct: 282 EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLL 341

Query: 230 Y---QAANGLAYIHEKNLMHRDVAARNCLYG 257
           Y   Q ++ + Y+ +KN +HRD+AARNCL G
Sbjct: 342 YMATQISSAMEYLEKKNFIHRDLAARNCLVG 372


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score =  112 bits (279), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 88/276 (31%), Positives = 134/276 (48%), Gaps = 39/276 (14%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    +YHG + R   + +L+    G FL+R SE   G  R   L   G       H+ +
Sbjct: 182 LEKHSWYHGPISRNAAEYLLSSGIDGSFLVRDSESSPGH-RSISLRFDGR----VYHYRI 236

Query: 64  RE-SDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-------- 113
              SD KV+V  +  F TI ELV+H+   K+S    DG +  +   A + QK        
Sbjct: 237 SSGSDGKVFVTTESKFSTIAELVHHHC--KQS----DGLITTLRYPAAKMQKPIIYGVSP 290

Query: 114 ----WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
               WE+   D+ +  KLG G +GEV++    K     H  + VAVKT + E+M   ++ 
Sbjct: 291 LPDEWEIERTDISMKNKLGGGQYGEVYEAIWKK-----HNKI-VAVKTLREENM---RVD 341

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKY 226
           E +REA +M+N+ H N+V+  GV     P Y++ E    G L   L    +   P +   
Sbjct: 342 EFLREAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYGNLLEYLRDNDETSLPAVTLL 401

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            +  Q A G++Y+ + + +HRD+AARNCL G   +L
Sbjct: 402 YMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLL 437


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score =  111 bits (278), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 82/262 (31%), Positives = 131/262 (50%), Gaps = 32/262 (12%)

Query: 11  YYHGLLPREDIQEMLNK---PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESD 67
           + HG + R     +L +    G +L+R S+   G   Q+ L V  E K+   H+ + + D
Sbjct: 74  WCHGAISRNGADYLLKQHGIDGMYLVRESQSQPG---QYTLDVWKEGKSV--HYRITKGD 128

Query: 68  HKVYVDK-IGFPTIIELVNHY-------VSTKESFSTKDGTVKAVLKQAVERQKWELYHE 119
              +  + + FPTI EL+ H+        S+ +  + K      V+   +E+ KWEL   
Sbjct: 129 EGYFFRQGVCFPTIPELIQHHQTRSDGLCSSLDHIAPKAHAKTIVIGMDMEK-KWELKRS 187

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           +V L  +LG G +GEV+KG         +    VA+KT K ESM   +  E M+EA +M+
Sbjct: 188 EVILGDRLGGGNYGEVFKGI--------YNNKTVAIKTIKEESM---ETVEFMKEAHVMK 236

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL----GKLHFPMIKKYELIYQAANG 235
            L H N+VK  GV +   P+Y++ E    G L S L     ++    +    +  Q A+G
Sbjct: 237 KLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLRLPQSRIQLDHVSMLYIAQQIADG 296

Query: 236 LAYIHEKNLMHRDVAARNCLYG 257
           ++ +  +N +HRD+AARNCL G
Sbjct: 297 MSALEAQNTIHRDLAARNCLVG 318


>UniRef50_C4Q4A1 Term=tyrosine kinase
           5;db_xref=PMID:11289068;with=UniProt:Q9NH62;evidence=tra
           cea ble author statement n=2 Tax=Schistosoma mansoni
           RepID=C4Q4A1_SCHMA
          Length = 653

 Score =  111 bits (278), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 83/273 (30%), Positives = 136/273 (49%), Gaps = 41/273 (15%)

Query: 9   QKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKK------TSA 58
           ++++  +L R+D + +L    N  G FL+R SE  +G      LSV  E++       + 
Sbjct: 177 EEWFMPMLSRKDSERLLLLEGNAQGVFLVRESETSQGS---LTLSVRDEERGLSGIMNTV 233

Query: 59  NHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAV------- 109
            H+ ++  D++ Y    K  F ++ EL+  Y         K    +A L           
Sbjct: 234 KHYRIKHPDYRYYYITTKCSFSSLQELIQFYSIDSHGLCCK--LTRACLCPPPITSDLSV 291

Query: 110 -ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
             +  WE+    + L +KLG G FGEVWKG      +       VAVKT K  +MTKE  
Sbjct: 292 KTKDHWEISKSSIVLIEKLGAGQFGEVWKGTWNGTTE-------VAVKTLKQGTMTKE-- 342

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL----GKLHFPMIK 224
            + ++EAR+MR   H  +V+ + V    +P+Y++ EL   G+L   L    GK +  + +
Sbjct: 343 -DFLKEARIMRAAQHPKLVRLYAVCT-EDPIYIVTELMCNGSLLQYLRDGPGK-NLLINQ 399

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
             +++ Q ANG+AY+ +++ +HRD+AARN L G
Sbjct: 400 LVDMMAQIANGMAYLEKEHYIHRDLAARNILVG 432


>UniRef50_A8XXS8 Putative uncharacterized protein n=2 Tax=Caenorhabditis briggsae
           AF16 RepID=A8XXS8_CAEBR
          Length = 403

 Score =  110 bits (276), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 71/196 (36%), Positives = 110/196 (56%), Gaps = 24/196 (12%)

Query: 62  VVRESDHKVYVDKI-GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           V++   +  Y ++   F +I EL+ +Y  TK + +    T +  LK  +  Q WE +H D
Sbjct: 74  VIKRVSNMFYCEQTRPFDSITELITYY--TKHTGACTSATFQ--LKNPILLQPWEFHHSD 129

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLES-MTKEQIKEIMREARLMR 179
           V + K LGEGAFG+V  G L K+ D +   V VA+K  K+ + ++K +I+E+M EAR +R
Sbjct: 130 VTVGKVLGEGAFGKVCSGTL-KLKDGS--VVEVAIKMTKVSAFLSKLKIREMMNEARFIR 186

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYI 239
           N +H NVV+ +GVA   +PLY+++EL  GG+L   + K               ANG    
Sbjct: 187 NFNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDHMKK-------------AKANGTTVT 233

Query: 240 HEKNLMHRDVAARNCL 255
             + +  +D+AARNCL
Sbjct: 234 IAERI--KDIAARNCL 247


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  110 bits (276), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 84/273 (30%), Positives = 141/273 (51%), Gaps = 38/273 (13%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           K L  ++++ G + R + ++MLN+     G FL+R SE   G+   F LSV  + +    
Sbjct: 115 KSLDAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGD---FSLSVKDQDRV--R 169

Query: 60  HFVVRE-SDHKVYVDKIG-FPTIIELVNHYVSTKESFSTK---------DGTVKAVLKQA 108
           H+ VR   D  ++V +   F  + ELV+HY    +    K               +L+QA
Sbjct: 170 HYRVRRLEDGSLFVTRRSTFQILHELVDHYKIETDGLCCKLLYPCLQAEKPQTAGLLRQA 229

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
            E  +WE+    ++L ++LG G FGEVW+G         +    VAVKT K  +M+   +
Sbjct: 230 NE--EWEIEKTQIKLLRRLGAGQFGEVWEGLW-------NGTTSVAVKTLKPGTMS---V 277

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL----GKLHFPMIK 224
           +E ++EA +M+ L H  +++ + V    EP+Y++ EL   G+L   L    G L    + 
Sbjct: 278 EEFLQEASIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQL- 336

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
             ++  Q A+G++Y+ ++N +HRD+AARN L G
Sbjct: 337 -VDVAAQVASGMSYLEQQNYIHRDLAARNILVG 368


>UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californica
           RepID=B6DVV3_APLCA
          Length = 517

 Score =  110 bits (275), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 81/244 (33%), Positives = 120/244 (49%), Gaps = 28/244 (11%)

Query: 26  NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN----HFVVRESDHK---VYVDKIGFP 78
           N  G FL+R +     +K  +VLSV    K S      H+ VR+ D +       K  F 
Sbjct: 145 NPRGTFLVREAT----DKSTYVLSVRDNDKASGEPCVKHYRVRKMDDERGYFISAKKTFK 200

Query: 79  TIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKG 138
           T+ +++ HY    +    + G      +  V+ ++ E+  E +ELT KLG G FGEVWKG
Sbjct: 201 TLFDVIEHYKDNSDGLCCQLGAACPRSRPTVQFRELEIKREVIELTNKLGAGCFGEVWKG 260

Query: 139 KLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEP 198
           KL K+++       VAVKT K  +M+ E     + EA++M  L H  +V+   V +  EP
Sbjct: 261 KLRKVVE-------VAVKTLKPGTMSSEA---FLNEAKIMHKLTHAKLVQLMAVVSVQEP 310

Query: 199 LYVIMELADGGALDSAL-----GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARN 253
             +I EL   GAL   L      KL F ++   ++  Q A G+ Y+   N +HRD+ A N
Sbjct: 311 FLIITELMVNGALLDYLRSEEGKKLKFDVL--IDMNAQVAEGMTYLESVNFVHRDLRAAN 368

Query: 254 CLYG 257
            L G
Sbjct: 369 ILVG 372


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  110 bits (274), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 81/267 (30%), Positives = 127/267 (47%), Gaps = 29/267 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    +YHG + R   + +L+    G FL+R SE   G++     S+         H+ +
Sbjct: 192 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYDGRVYHYRI 246

Query: 64  RE-SDHKVYVD-KIGFPTIIELVNHYVSTKES--------FSTKDGTVKAVLKQAVERQK 113
            E SD KVYV  +  F T+ ELV+H+    E         +         V   + E  +
Sbjct: 247 SEDSDGKVYVTAEAKFNTLAELVHHHSVLHEGHGLITPLLYPAPKQNKPTVFPLSPEPDE 306

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ + 
Sbjct: 307 WEICRTDIVMKHKLGGGQYGEVYEAVWKRYGNT------VAVKTLKEDTMA---LKDFLE 357

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY--- 230
           EA +M+ + H N+V+  GV     P Y+I E    G L   L       +    L+Y   
Sbjct: 358 EAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMAT 417

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYG 257
           Q A+G++Y+  +N +HRD+AARNCL G
Sbjct: 418 QIASGMSYLESRNFIHRDLAARNCLVG 444


>UniRef50_B3XVX8 Protein tyrosine kinase fes/fps n=1 Tax=Codonosiga gracilis
           RepID=B3XVX8_9EUKA
          Length = 792

 Score =  110 bits (274), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 79/253 (31%), Positives = 129/253 (50%), Gaps = 17/253 (6%)

Query: 12  YHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVY 71
           Y G +PR ++  +L+ PG FL+R     +    ++VLSV+ E     +  +    +  V 
Sbjct: 435 YFGPIPRNEVPMILSDPGDFLIRLGS--ENSATKYVLSVLEEGGNCRHFNIFYCPNGYVK 492

Query: 72  VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH-EDVELTKKLGEG 130
           ++K  FP+I  L+ HY+    S S   G     +   V R+K E++  +D+E   KLG+G
Sbjct: 493 IEKQEFPSISHLIRHYIDNDLSLSKNSG---VTIAHGVSRKKMEIWKPKDLESAAKLGKG 549

Query: 131 AFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFF 190
            FG V K K  KI D      + AVKT   ES+      E ++EA       H+N+    
Sbjct: 550 CFGVVQKMKS-KISDD-----VFAVKTCSDESV---HPWEFLKEALDFAKFKHVNICVHR 600

Query: 191 GVAAGTEPLYVIMELADGGALDSALGKLHFPMIK-KYELIYQAANGLAYIHEKNLMHRDV 249
           G++  + P +++M+L   GA++S L       ++ K++   +A  G+ Y+   N++HRD+
Sbjct: 601 GISL-SFPYFILMDLCGNGAVNSYLHDHKDTSLEIKFKWALEACEGMEYLTTNNVVHRDL 659

Query: 250 AARNCLYGGGQVL 262
           AARNCL     VL
Sbjct: 660 AARNCLLTDDLVL 672


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  110 bits (274), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 82/263 (31%), Positives = 129/263 (49%), Gaps = 27/263 (10%)

Query: 9   QKYYHGLLPREDIQEMLNKPGQ----FLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVR 64
           +++Y G + R+D + +L  PG     FL+R SE  KG     +      +  +  H+ +R
Sbjct: 156 EEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIR 215

Query: 65  ESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLK---QAVERQKWELYHE 119
           + D+  Y    +  F T+ +LV HY    +    K  TV   +K   Q + +  WE+  E
Sbjct: 216 KLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRE 275

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
            + L  KLG+G FGEVW G         +    VA+KT K  +M  E     ++EA++M+
Sbjct: 276 SLRLEVKLGQGCFGEVWMGTW-------NGTTKVAIKTLKPGTMMPEA---FLQEAQIMK 325

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL----GK-LHFPMIKKYELIYQAAN 234
            L H  +V  + V +  EP+Y++ E    G+L   L    GK L  P +   ++  Q A+
Sbjct: 326 KLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQL--VDMAAQIAD 382

Query: 235 GLAYIHEKNLMHRDVAARNCLYG 257
           G+AYI   N +HRD+ A N L G
Sbjct: 383 GMAYIERMNYIHRDLRAANILVG 405


>UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepID=Q8T6F8_CAEEL
          Length = 533

 Score =  109 bits (273), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 79/273 (28%), Positives = 131/273 (47%), Gaps = 42/273 (15%)

Query: 9   QKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSV--VGEKKT--SANH 60
           +++Y G +PR   + ++       G FL+R  E    + R+F L++    +++   +  H
Sbjct: 136 EEWYAGKIPRNRAERLVLSSHLPKGTFLIRERE---ADTREFALTIRDTDDQRNGGTVKH 192

Query: 61  FVVRESDHK---VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE------R 111
           + ++  DH        +  F ++ ELV +Y    +    +       L           +
Sbjct: 193 YKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQ 252

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
           Q WE+    + L +KLG+G FGEVW GK   I++       VA+KT K  +M+ E     
Sbjct: 253 QNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVE-------VAIKTMKPGTMSPE---AF 302

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGAL-------DSALGKLHFPMIK 224
           ++EA++M+  DH N+VK + V    EP Y+I E    G+L        S LG     +  
Sbjct: 303 LQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLG-----IQA 357

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
             ++  Q ANG+ Y+ E+ L+HRD+AARN L G
Sbjct: 358 LVDMAAQIANGMMYLEERKLVHRDLAARNVLVG 390


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score =  109 bits (273), Expect = 8e-23,   Method: Compositional matrix adjust.
 Identities = 84/272 (30%), Positives = 132/272 (48%), Gaps = 39/272 (14%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
            L    +YHG + R   + +L+    G FL+R SE   G+ R   L   G       H+ 
Sbjct: 7   SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQ-RSISLRYEGR----VYHYR 61

Query: 63  VRE-SDHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK------- 113
           +   SD K+YV     F T+ ELV+H+ +        DG +  +   A +R K       
Sbjct: 62  INTASDGKLYVSSESRFNTLAELVHHHSTVA------DGLITTLHYPAPKRNKPTIYGVS 115

Query: 114 -----WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
                WE+   D+ +  KLG G +GEV++G   K        + VAVKT K ++M   ++
Sbjct: 116 PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYS------LTVAVKTLKEDTM---EV 166

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYEL 228
           +E ++EA +M+ + H N+V+  GV     P Y+I E    G L   L + +   +    L
Sbjct: 167 EEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVL 226

Query: 229 IY---QAANGLAYIHEKNLMHRDVAARNCLYG 257
           +Y   Q ++ + Y+ +KN +HRD+AARNCL G
Sbjct: 227 LYMATQISSAMEYLEKKNFIHRDLAARNCLVG 258


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  109 bits (272), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 79/272 (29%), Positives = 130/272 (47%), Gaps = 29/272 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+ +
Sbjct: 257 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHYRI 311

Query: 64  RES-DHKVYV-DKIGFPTIIELVNHYVSTKES--------FSTKDGTVKAVLKQAVERQK 113
            E  D KV+V  +  F T+ ELV+H+    E         +         V   + E  +
Sbjct: 312 SEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDE 371

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ + 
Sbjct: 372 WEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT------VAVKTLKEDTMA---LKDFLE 422

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY--- 230
           EA +M+ + H N+V+  GV     P Y+I E    G L   L       +    L+Y   
Sbjct: 423 EAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMAT 482

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q A+G++Y+  +N +HRD+AARNCL G  +++
Sbjct: 483 QIASGMSYLESRNYIHRDLAARNCLVGDNKLV 514


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  108 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 79/272 (29%), Positives = 130/272 (47%), Gaps = 29/272 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+ +
Sbjct: 248 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHYRI 302

Query: 64  RES-DHKVYV-DKIGFPTIIELVNHYVSTKES--------FSTKDGTVKAVLKQAVERQK 113
            E  D KV+V  +  F T+ ELV+H+    E         +         V   + E  +
Sbjct: 303 SEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDE 362

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ + 
Sbjct: 363 WEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT------VAVKTLKEDTMA---LKDFLE 413

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY--- 230
           EA +M+ + H N+V+  GV     P Y+I E    G L   L       +    L+Y   
Sbjct: 414 EAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMAT 473

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q A+G++Y+  +N +HRD+AARNCL G  +++
Sbjct: 474 QIASGMSYLESRNYIHRDLAARNCLVGDNKLV 505


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  108 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 79/272 (29%), Positives = 130/272 (47%), Gaps = 29/272 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+ +
Sbjct: 249 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHYRI 303

Query: 64  RES-DHKVYV-DKIGFPTIIELVNHYVSTKES--------FSTKDGTVKAVLKQAVERQK 113
            E  D KV+V  +  F T+ ELV+H+    E         +         V   + E  +
Sbjct: 304 SEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDE 363

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ + 
Sbjct: 364 WEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT------VAVKTLKEDTMA---LKDFLE 414

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY--- 230
           EA +M+ + H N+V+  GV     P Y+I E    G L   L       +    L+Y   
Sbjct: 415 EAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMAT 474

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q A+G++Y+  +N +HRD+AARNCL G  +++
Sbjct: 475 QIASGMSYLESRNYIHRDLAARNCLVGDNKLV 506


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  108 bits (270), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 83/266 (31%), Positives = 135/266 (50%), Gaps = 31/266 (11%)

Query: 5   DLLHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVV----GEKKTSA 58
           DL ++ ++HG + R + + +L  ++PG FL+R SE +KG    + L+++    G K+ S 
Sbjct: 62  DLTNEPWFHGNIGRIEAENLLQYSEPGTFLIRESETIKG---SYTLTMIQIKDGTKQIS- 117

Query: 59  NHFVVRESDHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK---W 114
            HF +   D K ++     F  + +L+ HY+   +  +     V    K ++E  +   W
Sbjct: 118 -HFRINYDDGKYFITSARRFLGLHQLIQHYMQNSDGLACN--LVYPQPKPSIEYMELDVW 174

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+    ++L  KLG G FG+VWKG     LD +     VA+K  ++ +MT E   E   E
Sbjct: 175 EIDRGRLKLETKLGSGGFGDVWKG----TLDGS---FTVAIKQLQIGTMTTEAFLE---E 224

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKYELIYQ 231
           A+ M+ L H  +VK   V   TEP+Y++ E    G L S L   G     +    ++  Q
Sbjct: 225 AKAMKQLQHDKLVKLHAVVP-TEPVYIVSEFMCNGDLLSYLKRKGSYDLQLGDLLDMAAQ 283

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYG 257
            A+G+A+I   N +HRD+ A N L G
Sbjct: 284 VASGMAFIEANNYIHRDLRAANILVG 309


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  108 bits (269), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 85/275 (30%), Positives = 136/275 (49%), Gaps = 43/275 (15%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLN----KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
           +K    +++Y G + R + ++ L       G FL+R +E   G    F LSV      S 
Sbjct: 118 EKSYEAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVG---NFSLSV--RDGDSV 172

Query: 59  NHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAV---------LKQ 107
            H+ VR+ D   Y    +  F ++ ELV HY  TK++    DG V A+         +  
Sbjct: 173 KHYRVRKLDTGGYFITTRAPFNSLYELVQHY--TKDA----DGLVCALTLPCPKDKPVTG 226

Query: 108 AVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
            + +  WE+  E + L +KLG G FGEVW G    + +   Q   VAVKT K  +M+   
Sbjct: 227 GIAKDAWEIPRESLRLNRKLGAGQFGEVWAG----VWNNTTQ---VAVKTLKPGTMSP-- 277

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK-----LHFPM 222
               + EA +M+ L H ++V+ + + +  EP+Y++ E   GG+L   L K     L  P 
Sbjct: 278 -ASFLDEAGVMKKLRHKHLVQLYAICSDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLPT 336

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
           +   ++  Q A+G+A++  +  +HRD+AARN L G
Sbjct: 337 L--IDMAAQVASGMAFLEAQGYIHRDLAARNILVG 369


>UniRef50_Q19704 Protein F22B3.8, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q19704_CAEEL
          Length = 442

 Score =  107 bits (267), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 93/305 (30%), Positives = 140/305 (45%), Gaps = 54/305 (17%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTS-EPVKGEKRQ-------------- 45
           M D  LL  +++HG + +E    +L   G FLLR S +P K  K+               
Sbjct: 1   MIDNYLLRYQFFHGFVLQELQLILLKTNGDFLLRLSHQPEKNAKKPTTPDKSATDPIPLT 60

Query: 46  ---FVLSVVGEKKTSAN-----------------HFVVRESDHK---VYVD-KIGFPTII 81
               VLSV   +KT                    H  + E+  K    Y++ +  FPTI 
Sbjct: 61  RVILVLSVNITQKTGTTRSFYGDLEDVKKENMDMHLFIEETAGKWTSFYIERRFKFPTID 120

Query: 82  ELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT-KKLGEGAFGEVWKGKL 140
           EL+N+Y      +       +  LK+ +  Q WEL  E +++T KKLGEGAFG V+ G+ 
Sbjct: 121 ELINYYKVNPICYH----NTRVFLKRPIVLQDWELRAEGIDMTPKKLGEGAFGIVYLGRW 176

Query: 141 LKILDAN----HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGT 196
            +    +    H+   VAVKT K +  ++  + E+M EARL   L H NV+ F GV    
Sbjct: 177 AQPFSVDQKEFHKWCDVAVKTVKNDD-SRAALLEVMHEARLQLQLRHKNVLAFRGVFLLK 235

Query: 197 EPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLY 256
           +P+ ++ E       ++ L K    + +K      ++ GL YIH K L+HRD+A RN L 
Sbjct: 236 KPIMLVSEFC-----ENYLQKSKVSVDEKLRFCLGSSCGLEYIHFKGLIHRDLATRNILV 290

Query: 257 GGGQV 261
              + 
Sbjct: 291 SADKT 295


>UniRef50_A8WVF6 Putative uncharacterized protein n=2 Tax=root RepID=A8WVF6_CAEBR
          Length = 579

 Score =  107 bits (266), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 84/280 (30%), Positives = 133/280 (47%), Gaps = 39/280 (13%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLR--TSEPVK-GEKRQFVL---SVVGEKKTSAN 59
           L    Y+HG +   + +EML   G FL+R  T+E VK G  R F     + V   + S N
Sbjct: 6   LTSLPYFHGTIDTRECREMLPDLGDFLIRNPTNEMVKSGGTRTFACILTTAVTPDQASEN 65

Query: 60  ------------HFVVRESDHKVYVDK-----IGFP----TIIELVNHYVSTKESFSTKD 98
                           R   + + ++      +G P    ++ EL N Y S++++F    
Sbjct: 66  SKMLPKDYSLRLECTTRLKSYGIILENGVYSLLGTPETYQSVEELCNAYTSSRKAFPQGG 125

Query: 99  GTVKAVLKQAVERQKWELYHEDVELTKK---LGEGAFGEVWKGKLLKILDANHQPVLVAV 155
             ++      V R+ W+L   D+E       LG G FG+V +GKLL+       P+ VA+
Sbjct: 126 MALR-----PVARRPWQLLLSDIEFPVPEVVLGSGEFGKVIRGKLLR---HGVPPIDVAL 177

Query: 156 KTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL 215
           K A  E+   E I E+  EAR MR L H N+++F GV     PLY+++E  +G +L  AL
Sbjct: 178 KRATAENHA-EIISEMFTEARAMRALMHPNIIRFEGVVVEKLPLYLVIEFLEGSSLLDAL 236

Query: 216 GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
            K     + ++ +       + ++H  N +HRD+AARN +
Sbjct: 237 RKKKVNNVYRFPICMAVLYAVLWMHMHNYIHRDIAARNVM 276


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  107 bits (266), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 78/265 (29%), Positives = 125/265 (47%), Gaps = 29/265 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    +YHG + R   + +L+    G FL+R SE   G++     S+         H+ +
Sbjct: 268 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYDGRVYHYRI 322

Query: 64  RES-DHKVYV-DKIGFPTIIELVNHYVSTKES--------FSTKDGTVKAVLKQAVERQK 113
            E  D KV+V  +  F T+ ELV+H+    E         +         V   + E  +
Sbjct: 323 SEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDE 382

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ + 
Sbjct: 383 WEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT------VAVKTLKEDTMA---LKDFLE 433

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY--- 230
           EA +M+ + H N+V+  GV     P Y+I E    G L   L       +    L+Y   
Sbjct: 434 EAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMAT 493

Query: 231 QAANGLAYIHEKNLMHRDVAARNCL 255
           Q A+G++Y+  +N +HRD+AARNCL
Sbjct: 494 QIASGMSYLESRNYIHRDLAARNCL 518


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  107 bits (266), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 80/257 (31%), Positives = 125/257 (48%), Gaps = 41/257 (15%)

Query: 26  NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVY--VDKIGFPTIIEL 83
           N+ G FL+R SE        + LSV      +  H+ +R+ D   +    +  F T+ EL
Sbjct: 149 NEHGAFLIRDSE---SRHNDYSLSV--RDGDTVKHYRIRQLDEGGFFIARRTTFRTLQEL 203

Query: 84  VNHYVSTKESFSTKDGTVKAVLKQAVE-------------RQKWELYHEDVELTKKLGEG 130
           V HY  +K+S    DG    + K  V+             R +WE+    ++  +KLG G
Sbjct: 204 VEHY--SKDS----DGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSG 257

Query: 131 AFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFF 190
            FG+VW+G     L  N  PV  A+KT K  +M     K+ + EA++M+ L H  +++ +
Sbjct: 258 QFGDVWEG-----LWNNTTPV--AIKTLKSGTMDP---KDFLAEAQIMKKLRHTKLIQLY 307

Query: 191 GVAAGTEPLYVIMELADGGALDSALGKL-----HFPMIKKYELIYQAANGLAYIHEKNLM 245
            V    EP+Y+I EL   G+L   L  +        M    ++  Q A G+AY+  +N +
Sbjct: 308 AVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYI 367

Query: 246 HRDVAARNCLYGGGQVL 262
           HRD+AARN L G G ++
Sbjct: 368 HRDLAARNVLVGDGNIV 384


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  106 bits (265), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 78/269 (28%), Positives = 128/269 (47%), Gaps = 31/269 (11%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           KD+    +YH  + R   + +L     G FL+R S    GE     L   G+ +T   H+
Sbjct: 121 KDINRNPWYHSNISRNTAEYLLKSGVDGSFLVRESLSSPGEY-SITLRCDGKART---HY 176

Query: 62  VVRESDHKVYVDKIG--FPTIIELVNHY-------VSTKESFSTKDGTVKAVLKQAVERQ 112
            +   D + Y    G  F T+ +LV H+       V+  +    +    K ++    E +
Sbjct: 177 RINH-DARGYFVAAGKFFATVEQLVAHHAVVADGLVACLKQHPVEKAEAKPLVLSKEEDE 235

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WE+   ++ L  +LGEG +GEV+ G+          P  VA+KT K  +M   + K+ M
Sbjct: 236 QWEIARSEIVLGHRLGEGQYGEVYVGEW--------GPHRVAIKTIKDGAM---EAKDFM 284

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGAL----DSALGKLHFPMIKKYEL 228
           +EA +M+ + H N+V+  GV     PL+++ E  + G L     S  G+           
Sbjct: 285 KEADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQSERGRAEIDPTSMMHC 344

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYG 257
             Q A G++++ EK+ +HRD+AARNCL G
Sbjct: 345 ALQIAEGMSFLEEKHFIHRDLAARNCLVG 373


>UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186E29F
          Length = 466

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 75/239 (31%), Positives = 122/239 (51%), Gaps = 27/239 (11%)

Query: 26  NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIGFPTIIELVN 85
           N+ G FL+R SE     +  + LSV      +  H+ +      ++  K  F T+ ELV 
Sbjct: 120 NEHGAFLIRDSE---SRRNDYSLSV--RDGDTVKHYRIDIRRRWIFCSKNNFRTLQELVE 174

Query: 86  HYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILD 145
           H         T +  V   L  +  R +WE+  + ++  +KLG G FG+VW+G     L 
Sbjct: 175 H---------TIEKPVTGGLSHST-RDQWEIDRKSLKFVRKLGHGQFGDVWEG-----LW 219

Query: 146 ANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMEL 205
            N  PV  A+KT K  +M     K+ + EA++M+ L H  +++ + V    EP+Y+I EL
Sbjct: 220 NNTTPV--AIKTLKPGTMDP---KDFLAEAQIMKKLRHQKLIQLYAVCTMEEPIYIITEL 274

Query: 206 ADGGALDSAL-GK-LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              G+L   L GK     + +  ++  Q A+G+A++  +N +HRD+AARN L G G ++
Sbjct: 275 MKNGSLLEYLQGKGRQLKLAQLVDMAAQIASGMAFLESQNYIHRDLAARNVLVGDGNIV 333


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score =  105 bits (263), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 77/251 (30%), Positives = 121/251 (48%), Gaps = 34/251 (13%)

Query: 26  NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKI-GFPTIIELV 84
           N  G FL+R SE    +   +VLSV    K +A HF + ++  + YVD +  F +I+E++
Sbjct: 153 NNYGSFLVRVSE---SDDMGYVLSV--RTKENAKHFKIFQTGDQFYVDALFKFSSIVEVI 207

Query: 85  NHY----VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKL 140
            HY    +S  +  S     +K          +WEL  E+ +L  +LG G F +V+ GK 
Sbjct: 208 EHYQSHPLSIGDLLSEPCIRIKPENVPPPSTDEWELPKEEFQLENQLGSGHFADVYSGKW 267

Query: 141 LKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLY 200
                 NH  V + +    L++     ++E   E ++M+ L H +++  F V   + P Y
Sbjct: 268 -----KNHSKVAIKI----LKNNDALVLREFQLEVQIMKRLRHKHLISLFAVCTSSSPFY 318

Query: 201 VIMELADGGALDSALGKLHF---------PMIKKYELIYQAANGLAYIHEKNLMHRDVAA 251
           +I EL + G L      LHF          M    ++  Q A+G+AY+   N +HRD+AA
Sbjct: 319 IITELIEKGDL------LHFLRNPEGRSLQMESLIDMAAQVADGMAYLEANNSIHRDLAA 372

Query: 252 RNCLYGGGQVL 262
           RN L G G V 
Sbjct: 373 RNVLVGDGYVC 383


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  105 bits (263), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 79/265 (29%), Positives = 131/265 (49%), Gaps = 27/265 (10%)

Query: 11  YYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES-D 67
           +YHG + R   + +L+    G FL+R SE   G+     LS+    +    H+ +  + D
Sbjct: 173 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQ-----LSISLRYEGRVYHYRINTTAD 227

Query: 68  HKVYVD-KIGFPTIIELVNHYVSTKES------FSTKDGTVKAVLKQAVERQKWELYHED 120
            KVYV  +  F T+ ELV+H+ +  +       +         V   +    KWE+   D
Sbjct: 228 GKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTD 287

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           + +  KLG G +GEV+ G   K        + VAVKT K ++M   +++E ++EA +M+ 
Sbjct: 288 ITMKHKLGGGQYGEVYVGVWKKYS------LTVAVKTLKEDTM---EVEEFLKEAAVMKE 338

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY---QAANGLA 237
           + H N+V+  GV     P Y++ E    G L   L + +   +    L+Y   Q ++ + 
Sbjct: 339 IKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAME 398

Query: 238 YIHEKNLMHRDVAARNCLYGGGQVL 262
           Y+ +KN +HRD+AARNCL G   V+
Sbjct: 399 YLEKKNFIHRDLAARNCLVGENHVV 423


>UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein tyrosine kinase n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E4736E
          Length = 387

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 84/269 (31%), Positives = 134/269 (49%), Gaps = 38/269 (14%)

Query: 14  GLLPREDIQEML-----NKPGQFLLRTSEPVKGEKRQFVLSVVG---EKKTSANHFVVRE 65
           G+  R+D ++ L     NK GQF++R  +P       F LSV     +K     H+ + +
Sbjct: 10  GMCSRQDAEKKLMAIGINK-GQFIVRDRDP-----GTFELSVRDNNPQKGDHVKHYRIWK 63

Query: 66  SD--HKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQ-----AVERQKWELY 117
            D  +  ++ +   FPT+ ELV HY    +    K    +A  K+      + + KWE  
Sbjct: 64  MDGGNSFFIFQGSVFPTVSELVRHYQMNSDGLCCK--LTEACPKENPNTIGLGKDKWETP 121

Query: 118 HEDV-ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
            + + ++ ++LGEG FGEVW+G    + + N     VAVKT K  +M+       + EA 
Sbjct: 122 RKSLGQMNRRLGEGKFGEVWQG----VWNGN---TPVAVKTLKERTMSPAAF---LAEAN 171

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAA--- 233
           +M+ L H  +V+ + V +  EP+Y++ EL   G L + L        K   LI   A   
Sbjct: 172 VMKKLRHEGIVQLYAVCSDKEPIYIVTELMSNGDLRTYLKSDKCKNTKMTTLIDMGAHIA 231

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +G+ Y+  KN++HRD+AARN L G G V+
Sbjct: 232 SGMDYLGSKNVVHRDLAARNVLVGKGNVV 260


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 79/266 (29%), Positives = 129/266 (48%), Gaps = 28/266 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+ +
Sbjct: 169 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHYRI 223

Query: 64  RE--SDHKVYVD-KIGFPTIIELVNHYVSTKESFSTK------DGTVKAVLKQAVERQKW 114
            E  SD KVYV  +  F T+ ELV+H+    +   T+            V   + E  +W
Sbjct: 224 NEDTSDGKVYVTTESRFNTLAELVHHHSMHSDGLITQLLYPAPKHNKPTVFALSPEPDEW 283

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+   D+ +  KLG G +G+V++    +        + VAVKT K ++M    +K+ + E
Sbjct: 284 EINRTDIVMRHKLGGGQYGDVYEAVWKRY------NMTVAVKTLKEDTMA---LKDFLEE 334

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY---Q 231
           A +M+ + H N+V+  GV     P Y+I E    G L   L + +   I    L+Y   Q
Sbjct: 335 AAIMKEMKHPNLVQLLGVCTREPPFYIITEFMSKGNLLDYLRQGNRENINAVVLMYMATQ 394

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYG 257
            A+ ++Y+  +  +HRD+AARNCL G
Sbjct: 395 IASAMSYLESRMFIHRDLAARNCLVG 420


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  105 bits (261), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 80/271 (29%), Positives = 126/271 (46%), Gaps = 30/271 (11%)

Query: 9   QKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVR 64
           +++Y G L R+D +  L    N  G FL+R SE  KG     +      K     H+ +R
Sbjct: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIR 206

Query: 65  ESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTK------DGTVKAVLKQAVERQKWEL 116
           + D+  Y    +  F T+ +LV HY         +       G  +        +  WE+
Sbjct: 207 KLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEI 266

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
             E ++L K+LG G FGEVW G      + N +   VA+KT K  +M+ E   E   EA+
Sbjct: 267 PRESLQLIKRLGNGQFGEVWMG----TWNGNTK---VAIKTLKPGTMSPESFLE---EAQ 316

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGAL-----DSALGKLHFPMIKKYELIYQ 231
           +M+ L H  +V+ + V +  EP+Y++ E  + G+L     D     L  P +   ++  Q
Sbjct: 317 IMKKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNL--VDMAAQ 373

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            A G+AYI   N +HRD+ + N L G G + 
Sbjct: 374 VAAGMAYIERMNYIHRDLRSANILVGNGLIC 404


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score =  103 bits (258), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 82/268 (30%), Positives = 133/268 (49%), Gaps = 40/268 (14%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L  + YYHG +PR   +  L+    G FL+R S+   GE     +S+  + K    H+ +
Sbjct: 174 LDSEPYYHGRIPRTTAEFFLSNGINGSFLVRESQSNAGE---HTISLRCDGKVF--HYRI 228

Query: 64  RESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ--------- 112
             +D  V++  D++ F T+ +LV  Y          DG V   L+ AV +          
Sbjct: 229 SRTDKGVFIAADRV-FSTVQDLVKFY------HQQSDGLVHP-LRHAVPKNRQEITASPS 280

Query: 113 -KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            KWE+    + +  +LG G +GEV++  L    + N     VAVKT K E+M   + K+ 
Sbjct: 281 DKWEIDRSSIMMGTRLGAGQYGEVYEAVLT---NKNRH---VAVKTLKEEAM---EAKDF 331

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIME-LADGGALDSALGKLHFPMIKKYELIY 230
           ++EA +M+ L H N+V+  GV     PLY++ E + +G  LD     +    I    ++Y
Sbjct: 332 LKEAEVMKKLKHPNLVELIGVCTLESPLYIVTEYMCNGCLLDYIRDPIKQKEITPTAMMY 391

Query: 231 ---QAANGLAYIHEKNLMHRDVAARNCL 255
              Q + G+ ++  +N +HRD+AARNCL
Sbjct: 392 IAEQISAGMEFLESQNFIHRDLAARNCL 419


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score =  103 bits (258), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 80/265 (30%), Positives = 134/265 (50%), Gaps = 28/265 (10%)

Query: 7   LHQ-KYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           LH+  ++ G + RE  +E+L   + G FL+R S    G+    V+S    KK   ++ V+
Sbjct: 87  LHEMPWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVE-HYRVI 145

Query: 64  RESDHKVYVDKIGF-PTIIELVNHYVSTKESFST------KDGT---VKAVLKQAVERQK 113
             SD++V VD+  F PT+IEL+ HY    +   T      K  T     A+ K++ +++ 
Sbjct: 146 STSDNQVTVDEEAFFPTLIELIKHYEKDADGLCTMLKKPLKKKTEILQSAIFKESFQKEG 205

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           W +  EDVE  + +G+G FG V+KG   K          VA+K  + +S T +    ++ 
Sbjct: 206 WAVPIEDVEFKELIGKGEFGNVYKGVWAK--------KTVAIKKLRDDSKTAQS---LLA 254

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKYELIY 230
           EA +M  L H N+V    ++   + + ++ E  + G L   L   G+    + ++     
Sbjct: 255 EASVMTTLQHKNLVVLVAISFQGDSILILTEYCEKGVLVEYLRTRGRAVITLEEQKGFAI 314

Query: 231 QAANGLAYIHEKNLMHRDVAARNCL 255
              NG+ Y+ EKN++HRD+AARN L
Sbjct: 315 DVCNGMRYLEEKNIIHRDLAARNVL 339


>UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosine kinase 6 n=1 Tax=Danio
           rerio RepID=UPI000175FB8C
          Length = 510

 Score =  103 bits (256), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 86/279 (30%), Positives = 143/279 (51%), Gaps = 47/279 (16%)

Query: 9   QKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVV-GEKKTSANHFVV 63
           Q +Y G L R + + +L  P    G FL+R SE    +   +VLSV+ G++     H  +
Sbjct: 121 QPWYFGTLNRFETEILLLAPENDVGAFLVRHSE---KDNIGYVLSVLSGDRSREVKHIKI 177

Query: 64  RES-DHKVYVDKI-GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-------- 113
            ++ +   Y+DK   F ++ +LV++Y        + DG   + LKQ   R +        
Sbjct: 178 HQNQNESFYLDKSQTFQSLEKLVDYYWKY-----SLDG--DSFLKQPCRRPEPKPKDLSH 230

Query: 114 -----WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
                WEL  E+  L ++LG+G F +V++GK   +++       VA+K  K +S+     
Sbjct: 231 STVNDWELPKEEFTLEEELGKGFFADVYRGKWKGMVN-------VAIKILKNDSINH--- 280

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL-GK----LHFPMI 223
           +E M E ++++ L H +++  F V   + P Y+I EL + G L S L GK    L+  M+
Sbjct: 281 REFMLETQILKKLRHKHLIALFAVCTSSSPFYIITELMEKGDLLSLLKGKEGQDLNAQML 340

Query: 224 KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              E+  Q A+G+AY+ E+N +HRD+AARN L G   + 
Sbjct: 341 T--EMASQVADGMAYLEEQNSIHRDLAARNVLVGANYIC 377


>UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni RepID=Q70DV1_SCHMA
          Length = 647

 Score =  102 bits (255), Expect = 9e-21,   Method: Compositional matrix adjust.
 Identities = 80/275 (29%), Positives = 130/275 (47%), Gaps = 37/275 (13%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNKPGQ----FLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
            L   ++Y G L R + +  L  PG     FL+R SE    +  ++ LSV   ++ +  H
Sbjct: 216 SLESNEWYFGELKRIEAEHYLQLPGNDHGSFLVRISE---SQSSEYSLSV--REENTVKH 270

Query: 61  FVVRE-------SDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDG--TVKAVLKQAVE 110
           + +R        +  + Y+ + + F  I +LVNHY+  +     + G   ++    + V 
Sbjct: 271 YRIRSRYSRTDPTLKRFYISRQLPFVNIQQLVNHYLENQSGLCCRLGKPCIRPTHPEPVG 330

Query: 111 RQ-----KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTK 165
                  KWE+    + L +K+G+G FGEV+K    K         +VAVKT K  S   
Sbjct: 331 LSHKLIDKWEIPKSSIILKEKIGQGQFGEVFKAVWNKT-------TIVAVKTLKPSSC-- 381

Query: 166 EQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK 225
               + +REA+ M+ L H N+++ + V   TEP Y++ E    G+L + L       +  
Sbjct: 382 -DAADFLREAQTMKRLHHPNLIQLYAVCTQTEPFYIVTEYMSKGSLLNYLQSPEGNALNM 440

Query: 226 YELIYQAAN---GLAYIHEKNLMHRDVAARNCLYG 257
             LI  AA    G+AY+  +  +HRD+AARN L G
Sbjct: 441 QCLIMMAAKIAPGMAYLESRRHIHRDLAARNVLVG 475


>UniRef50_Q9XW34 Protein Y69E1A.3, partially confirmed by transcript evidence n=4
           Tax=Caenorhabditis elegans RepID=Q9XW34_CAEEL
          Length = 563

 Score =  102 bits (254), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 57/141 (40%), Positives = 85/141 (60%), Gaps = 3/141 (2%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           L H  + L KKLG GAFGEV+KG+  K + + + P+ VAVK   L +  ++QI+E   EA
Sbjct: 193 LIHSTINLDKKLGCGAFGEVFKGQY-KAVGSTNPPIEVAVKRI-LGNAKRKQIQEFCNEA 250

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAAN 234
           ++M  L H N+V F+G A+  EP+ V+MEL  GG L        + P ++        A+
Sbjct: 251 QIMTVLQHENIVAFYGFASLEEPIMVVMELVTGGDLRKYFQTTQNIPKLQILWFAMNVAS 310

Query: 235 GLAYIHEKNLMHRDVAARNCL 255
           G+ ++  K ++HRD+AARNCL
Sbjct: 311 GMRHLSSKGIIHRDLAARNCL 331


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  100 bits (249), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 75/264 (28%), Positives = 125/264 (47%), Gaps = 37/264 (14%)

Query: 11  YYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDH 68
           +YHG + R D + +L     G FL+R SE   G   Q+ +SV  + +       V  ++ 
Sbjct: 194 WYHGKISRSDSEAILGSGITGSFLVRESETSIG---QYTISVRHDGRVFHYRINVDNTEK 250

Query: 69  KVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK--------------W 114
                ++ F T+ ELV+H+          DG +  ++  A ++ K              W
Sbjct: 251 MFITQEVKFRTLGELVHHHSVHA------DGLICLLMYPASKKDKGRGLFSLSPNAPDEW 304

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           EL   ++ +  KLG G +G+V++G   +          +AVK  K ++M    + E + E
Sbjct: 305 ELDRSEIIMHNKLGGGQYGDVYEGYWKR------HDCTIAVKALKEDAMP---LHEFLAE 355

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKYELIYQ 231
           A +M++L H N+V+  GV     P Y+I E    G L   L    K   P I   ++  Q
Sbjct: 356 AAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQ 415

Query: 232 AANGLAYIHEKNLMHRDVAARNCL 255
            A+G++Y+  ++ +HRD+AARNCL
Sbjct: 416 IASGMSYLEARHFIHRDLAARNCL 439


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score = 99.8 bits (247), Expect = 8e-20,   Method: Compositional matrix adjust.
 Identities = 79/244 (32%), Positives = 120/244 (49%), Gaps = 30/244 (12%)

Query: 29  GQFLLRTSEPVKGEKRQFVLSVV----GEKKTSANHFVVRESDHK--VYVD-KIGFPTII 81
           G FL+R SE   G    + L+V     G   T  N+ V +  D     +++ +  F T+I
Sbjct: 135 GTFLVRESETRPG---TYALTVRETDHGHPPTIKNYRVDKTKDGSELFFINPQRKFNTVI 191

Query: 82  ELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-----WELYHEDVELTKKLGEGAFGEVW 136
           ++V  + S      +K   +K   KQ    +      WEL    ++L  KLG+G FG VW
Sbjct: 192 DVVKFHTSQPGGLCSK--LLKPCPKQTPNTRTLGHEVWELPRSSLKLLDKLGQGQFGAVW 249

Query: 137 KGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGT 196
           KG    I D     V VAVKT +  +M+ E     + EA LM+ L H+ +V  +G+ +  
Sbjct: 250 KG----IYDGK---VEVAVKTLRPGTMSPEAF---LAEANLMKELKHVKLVNLYGICSDE 299

Query: 197 EPLYVIMELADGGALDSAL---GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARN 253
           EP+Y+I EL   G+L   L   G  +  + +  ++  Q A G+ Y+  K  +HRD+AARN
Sbjct: 300 EPIYIITELMVNGSLLGYLREGGGQYLGLRELVDIAAQIARGMNYLESKGYVHRDLAARN 359

Query: 254 CLYG 257
            L G
Sbjct: 360 VLIG 363


>UniRef50_A8WSQ7 Putative uncharacterized protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8WSQ7_CAEBR
          Length = 481

 Score = 99.8 bits (247), Expect = 9e-20,   Method: Compositional matrix adjust.
 Identities = 89/306 (29%), Positives = 141/306 (46%), Gaps = 56/306 (18%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTS-EPVK-----GEKRQ--------- 45
           M + +LL   ++HG + +E    +L   G +++R S +P K     G K+          
Sbjct: 26  MIENNLLRYPFFHGFVLQELQLMLLKTNGDYIMRLSHQPEKKAKSIGAKKASAEKTGPVD 85

Query: 46  --------FVLSV------------------VGEKKTSANHFVVRESDHK---VYVDK-I 75
                    VLSV                  V +K+    H  + E + K    +V++  
Sbjct: 86  QSTLTRVILVLSVNITQKPDNTRSFYGDLDEVKQKENMDMHVCIEEINGKWVSFFVERRT 145

Query: 76  GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL--TKKLGEGAFG 133
            F +I +L+ +Y +    +       +  LK+ +  Q WEL  + +E+  TKKLGEGA+G
Sbjct: 146 KFASIDDLITYYRTNPICYQA----TRVFLKRPIPLQDWELRKDGLEVIKTKKLGEGAYG 201

Query: 134 EVWKGKLLKILDAN----HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           EV+ GK  +    +    H+   VAVK  K +  ++  + EIM EARL   L H NV+ F
Sbjct: 202 EVYLGKWAQPFSVDQKEFHKWCDVAVKMLKKDD-SRAALFEIMHEARLQLQLRHKNVLAF 260

Query: 190 FGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
            GV    +P+ ++ E  + G+L   L K    +  K      ++ GL YIH K L+HRD+
Sbjct: 261 RGVFLLKKPIMLVSEFCENGSLKDYLQKNKVGVDDKLRFCLGSSCGLEYIHFKGLIHRDL 320

Query: 250 AARNCL 255
           A RN L
Sbjct: 321 ATRNIL 326


>UniRef50_A8PFG2 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8PFG2_BRUMA
          Length = 553

 Score = 99.4 bits (246), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 89/275 (32%), Positives = 140/275 (50%), Gaps = 43/275 (15%)

Query: 17  PREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIG 76
           P + I   L+KPG + +R+S     ++  FV++ V EK        VRE    VY++ + 
Sbjct: 8   PWDHIISHLSKPGDWCVRSSG-TNAKRLLFVITKVDEKN-------VRELKL-VYIENLK 58

Query: 77  FPTIIELVN---------HYVSTKESFSTKDGTVKAV-LKQAVERQKWELYHEDVELTK- 125
             T++++ N          Y S  E  S++    + + L+  + R  + L  E++++T  
Sbjct: 59  GWTLMDVKNVNRNNNELITYGSIHELLSSESSFCQKMNLRNPINRPNYLLNDENLKITNI 118

Query: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTA----KLESMTKEQIKEIMR-------- 173
           KLGEG + EV KG +LK+ D   + + VAVK      K+    K   K+I+R        
Sbjct: 119 KLGEGHYAEVLKG-MLKVGD---EEISVAVKRCLQVDKVSITDKRSTKDIIRIKLAKSQM 174

Query: 174 --EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE---L 228
             EARL+ +  H N++K +GVA  + P+ V+ME   GG+L + L K H   IK  E    
Sbjct: 175 IAEARLVCDFMHENIIKIYGVACNSAPVKVVMEYCPGGSLKNLLIK-HKETIKNEERNIF 233

Query: 229 IYQAANGLAYIHEKNLMHR-DVAARNCLYGGGQVL 262
           +++AA  L ++  K  +HR DVAARNCL G    L
Sbjct: 234 LFEAAKALRHLQLKKCVHRWDVAARNCLIGNNGSL 268


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score = 98.6 bits (244), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 77/242 (31%), Positives = 116/242 (47%), Gaps = 27/242 (11%)

Query: 25  LNKPGQFLLRTSEPVKGEKRQFVLSV--VGEKKTSANHFVVRESDHKVY--VDKIGFPTI 80
           +NK G FL+R SE  KG    F LSV  V  +     H+ +R  D   Y    +I FP++
Sbjct: 142 INKAGSFLIRESETNKG---AFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSL 198

Query: 81  IELVNHYVSTKESFSTKD--GTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKG 138
             LV HY    +    +     V+   +    + +WE+  + + L +KLG G FGEVW G
Sbjct: 199 QALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMG 258

Query: 139 KLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEP 198
                +        VA+KT K  +M+ E     + EA +M+ L H  +V+ + V    EP
Sbjct: 259 YYKNNMK-------VAIKTLKEGTMSPEA---FLGEANVMKALQHERLVRLYAVVT-KEP 307

Query: 199 LYVIME-LADGGALD----SALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARN 253
           +Y++ E +A G  LD        +L  P +   ++  Q A G+AYI   N +HRD+ A N
Sbjct: 308 IYIVTEYMARGCLLDFLKTDEGSRLSLPRL--IDMSAQIAEGMAYIERMNSIHRDLRAAN 365

Query: 254 CL 255
            L
Sbjct: 366 IL 367


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score = 98.6 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 83/274 (30%), Positives = 129/274 (47%), Gaps = 44/274 (16%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L  +K+YHG + R   + +LN    G FL+R SE   G   Q  +S+  E +    H+ +
Sbjct: 162 LESEKWYHGAIQRSYAEYLLNSGITGSFLIRESESHPG---QLTISLRYEGQIW--HYRI 216

Query: 64  RESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKW------- 114
              D  +Y  ++   F ++ +LV+H+   K S    DG    +L  A +R +        
Sbjct: 217 HRDDSNMYYVIESNKFTSVSDLVHHH--EKHS----DGLACTLLYPAPKRDRTSSELRMD 270

Query: 115 ------ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQP--VLVAVKTAKLESMTKE 166
                 E+   ++ +  KLG G +G V+        +A  +P  VLVAVKT K     ++
Sbjct: 271 PSFDIREIDRTEIVMKHKLGSGQYGVVY--------EAVWKPYNVLVAVKTLKENVTVRD 322

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKY 226
              E + EARLM++L H N+V   G      P Y++ E    G L   L       +   
Sbjct: 323 ---EFLEEARLMKSLRHPNLVTLLGACTREPPYYIVTEFMCNGNLLDYLRTHPRTELTPS 379

Query: 227 ELIY---QAANGLAYIHEKNLMHRDVAARNCLYG 257
            L++   Q A G+AY+ + N +HRD+AARNCL G
Sbjct: 380 VLLHMATQVARGMAYLEQHNFIHRDLAARNCLVG 413


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score = 98.2 bits (243), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 87/273 (31%), Positives = 133/273 (48%), Gaps = 33/273 (12%)

Query: 6   LLHQK--YYHGLLPREDIQEMLN----KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           +LH+K  ++HG + RE+ ++ +     + G FL+R     + E   F L V    K    
Sbjct: 156 ILHRKQLWFHGAISREESEQRMKAFGLRDGLFLVRE----RTEVNSFALCVA--VKNDIY 209

Query: 60  HFVVRESDHKVYVDKIG--FPTIIELVNHYVSTKESFSTKDGTVKAVLK---QAVERQKW 114
           H+++  +       + G  F  ++++V+HY  T +        V AV +   QAV     
Sbjct: 210 HYLLEMNTLGQLSIENGRKFENLLQVVDHYSRTPDGLLCTLVDVCAVTRFEAQAVPMPGA 269

Query: 115 ELYH--------EDVELTKK--LGEGAFGEVWKGKLLKILDANHQP-VLVAVKTAKLESM 163
            +          ED EL+ +  LG G FG V   +L      N +P V  A+K  K    
Sbjct: 270 VVKRVKHGPRRIEDSELSTQGELGAGTFGTV---RLGVYRPKNGEPEVQCALKYLKQSEE 326

Query: 164 TKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-FPM 222
              Q  EI+REA  M  LDH N+V+ FG+  G +P+ ++MELA  G L+  L K   FP+
Sbjct: 327 LPNQKAEILREADAMAALDHCNIVRLFGICVG-DPICLVMELARQGPLNKFLRKRPTFPV 385

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
           IK   +  Q + G+AY+ E   +HRD+AARN L
Sbjct: 386 IKILNMALQVSRGMAYLEEVRFVHRDLAARNVL 418


>UniRef50_C4XV88 Venus kinase receptor (Fragment) n=3 Tax=Coelomata RepID=C4XV88_STRPU
          Length = 1566

 Score = 97.8 bits (242), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 60/157 (38%), Positives = 87/157 (55%), Gaps = 18/157 (11%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +WE+  E+V L +KLGEGAFG V+ G+ L  LD N     VAVKT KL +  +E++ + +
Sbjct: 1012 EWEMPRENVVLNRKLGEGAFGTVYGGEAL--LDDNKWAA-VAVKTLKLGASVEEKL-DFL 1067

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDS-ALGKLHFPMIKKYE---- 227
             EA +M+  +H N+V   GV    EP+Y +ME    G L +  LG+ H      YE    
Sbjct: 1068 SEAEVMKRFNHKNIVNLLGVCTRGEPMYAVMEFMLYGDLKTFLLGRRHLVGEGVYERNQH 1127

Query: 228  ---------LIYQAANGLAYIHEKNLMHRDVAARNCL 255
                     ++   A+GL+Y+   N +HRD+A RNCL
Sbjct: 1128 VMCPDQLTSMVSDIASGLSYLASINYVHRDLACRNCL 1164


>UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax=Coelomata
           RepID=BMX_HUMAN
          Length = 675

 Score = 97.4 bits (241), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 78/261 (29%), Positives = 127/261 (48%), Gaps = 29/261 (11%)

Query: 11  YYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVR-ES 66
           ++ G + R   +++L    K G F++R S  V           V +KK +  H+ V   +
Sbjct: 296 WFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNA 355

Query: 67  DHKVYV-DKIGFPTIIELVNHY--------VSTKESFSTKDGTVKAVLKQAVERQKWELY 117
           ++K+Y+ +   F +I +L++++           +   STK   V   +  ++    WEL 
Sbjct: 356 ENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSV--SLGNGIWELK 413

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
            E++ L K+LG G FG V  GK     D       VAVK  K  SM+++   E  +EA+ 
Sbjct: 414 REEITLLKELGSGQFGVVQLGKWKGQYD-------VAVKMIKEGSMSED---EFFQEAQT 463

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKYELIYQAAN 234
           M  L H  +VKF+GV +   P+Y++ E    G L + L   GK   P  +  E+ Y    
Sbjct: 464 MMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPS-QLLEMCYDVCE 522

Query: 235 GLAYIHEKNLMHRDVAARNCL 255
           G+A++     +HRD+AARNCL
Sbjct: 523 GMAFLESHQFIHRDLAARNCL 543


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score = 96.3 bits (238), Expect = 8e-19,   Method: Compositional matrix adjust.
 Identities = 78/271 (28%), Positives = 131/271 (48%), Gaps = 36/271 (13%)

Query: 9   QKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGE-KRQFVLSVVGEKKTSANHFVV 63
           + +Y G + R D +++L    ++ G FL+R SE   G+    F LSV    K    H+ +
Sbjct: 127 EPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSV--RDKELIRHYRI 184

Query: 64  RESDHKVYVDKIG--FPTIIELVNHYVSTKESFSTK----DGTVKAVLKQAVE------R 111
           + +D   Y   +   F T+ EL+  Y  + +    K       V  + K+ V+      +
Sbjct: 185 KITDSGKYFISLSKEFSTLNELIEFYKISSDGLKIKLLEPCRKVCIMFKKQVQTFGLSHK 244

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            KWE+  + +E   ++G G FG+V+KG         +  + VA+K+ K   M K   K+ 
Sbjct: 245 DKWEISRDSLEFQSRVGSGQFGDVYKG-------VWNSKIPVAIKSLKPGYMDK---KQF 294

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL-----GKLHFPMIKKY 226
           + EA LM+ L H  +V+ + V    EPL ++ E    G+L   L      KL F  +   
Sbjct: 295 LAEANLMKQLRHPKLVQLYAVVTIEEPLLIVTEFMSNGSLLEFLRHNESKKLLFKEL--I 352

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
           ++  + A G+A++  K+ +HRD+AARN L G
Sbjct: 353 DICAEVAQGMAFLELKSFIHRDLAARNILVG 383


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score = 96.3 bits (238), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 71/265 (26%), Positives = 121/265 (45%), Gaps = 41/265 (15%)

Query: 11  YYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDH 68
           +YHG + R   + +L+    G FL+R SE  +G      LSV      S  H+       
Sbjct: 87  WYHGAVSRAAAEYLLSSGINGSFLVRDSESCRGH-----LSVSVRFNASVYHY------- 134

Query: 69  KVYVDKIG---------FPTIIELVNHYVSTKES------FSTKDGTVKAVLKQAVERQK 113
           ++ VD  G         F T+ ELV+H+    +       +     T  AV   A +  +
Sbjct: 135 RINVDTAGLFYISPEHRFQTLPELVHHHSYASDGLAAILHYPAAKSTKPAVYSMAPDYDE 194

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   ++ + ++LG G +G+V++    +          +AVKT + ++   E   E ++
Sbjct: 195 WEIDRSEIHMKQRLGGGQYGDVYEAVWKRYNKT------IAVKTFREDTTNTE---EFLK 245

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKYELIY 230
           EA +M+++ H N+V+  GV     P Y++ E    G L   L    K+    +    +  
Sbjct: 246 EAAVMKSIKHPNLVQLLGVCTREPPFYIVTEFMSEGNLLEYLRRCNKVELDGVVLLHISV 305

Query: 231 QAANGLAYIHEKNLMHRDVAARNCL 255
           Q A  + Y+  +N +HRD+AARNCL
Sbjct: 306 QVALAMEYLETRNYIHRDLAARNCL 330


>UniRef50_Q9U3B5 Protein K09B11.5a, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q9U3B5_CAEEL
          Length = 589

 Score = 96.3 bits (238), Expect = 8e-19,   Method: Compositional matrix adjust.
 Identities = 80/251 (31%), Positives = 130/251 (51%), Gaps = 19/251 (7%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKV 70
           +YHG++  + ++++L     +L+R +   +  K+   LSV  + K    HF +  +    
Sbjct: 76  WYHGMMFGQTVEKLLKWDYAYLVRRAM-QRNSKKVLCLSVKIDGKIC--HFTLNSNKDGW 132

Query: 71  YVDKI--GFPTII-ELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKL 127
              K+   FP I  +   H     +++S     V +++   V R++  L H  + L   L
Sbjct: 133 SCGKLLAKFPKITPKRFQHIHHLLDAWSL---VVNSIV--PVPRRQLVLQHNCIHLENIL 187

Query: 128 GEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVV 187
           G GAFGEV K + +     N   V VAVK   + +  +EQ++E   EA++M  L H NVV
Sbjct: 188 GNGAFGEVLKARYIPRGHTNG--VEVAVKRV-IGTAQREQMQEFCHEAQIMGTLKHDNVV 244

Query: 188 KFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQA---ANGLAYIHEKNL 244
           K +G+A+  +P+ ++MEL  GG L   L     P I   +LI  A   ANG+ ++  K +
Sbjct: 245 KLYGIASLEQPIMLVMELITGGDLKKYLQST--PSIPNRQLIAFALDIANGMRHLVIKKV 302

Query: 245 MHRDVAARNCL 255
           +HRD+AARNCL
Sbjct: 303 IHRDLAARNCL 313


>UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RNL0_TETNG
          Length = 509

 Score = 95.1 bits (235), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 85/275 (30%), Positives = 127/275 (46%), Gaps = 44/275 (16%)

Query: 9   QKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEK------RQ---------FVLS 49
           +++Y G + R+D +  L    N+ G FL+R SE  KGE       RQ         +   
Sbjct: 66  EEWYFGKMGRKDAERQLLAHGNQRGTFLIRESETTKGEHSHAHTLRQLPGRGLYVGYTSV 125

Query: 50  VVGEKKTSANHFVVRESDHKVYVDKIGFPTIIELVN--HYVSTKESFSTKDGTVKAVLKQ 107
            +  +   A    +R+ D     D +    I +L N  +Y++T    S K G  K     
Sbjct: 126 PLHSRFPGAYSLSIRDWDDNK-GDHVKHYKIRKLDNGGYYITT----SCKRGMPKLADLS 180

Query: 108 AVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
              +  WE+  E ++L KKLG G FGEVW G         +    VAVKT K  +M+ E 
Sbjct: 181 VKTKDMWEIPRESLQLIKKLGNGQFGEVWMGMW-------NGTTKVAVKTLKPGTMSPEA 233

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGAL-----DSALGKLHFPM 222
             E   EA++M+ L H  +V+ + V +  EP+Y+I E    G+L     D     L  P 
Sbjct: 234 FLE---EAQIMKRLRHDKLVQLYAVVS-EEPIYIITEFMSQGSLLDFLKDGEGQNLKLPQ 289

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
           +   ++  Q A+G+AYI   N +HRD+ A N L G
Sbjct: 290 L--VDMAAQIASGMAYIERMNYIHRDLRAANILVG 322


>UniRef50_C5H7R9 Venus kinase receptor (Fragment) n=2 Tax=Tribolium castaneum
            RepID=C5H7R9_TRICA
          Length = 1293

 Score = 94.7 bits (234), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 61/173 (35%), Positives = 89/173 (51%), Gaps = 23/173 (13%)

Query: 106  KQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQP---VLVAVKTAKLES 162
             Q  +  KWE+    V + +KLGEGAFG V+ G      +AN      V VAVKT K+ S
Sbjct: 886  SQITDLDKWEIPRNSVVINRKLGEGAFGTVYGG------EANFPDKGWVAVAVKTLKVGS 939

Query: 163  MTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDS-ALGKLHFP 221
             T+E++ + + EA +M+  DH N++K  GV    EP+Y IME    G L +  L + H  
Sbjct: 940  STEEKL-DFLSEAEVMKRFDHKNIIKLLGVCTKEEPIYTIMEFMLYGDLKTFLLARRHLV 998

Query: 222  MIKKYE------------LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              K  E            +    A GL+Y+ +   +HRDVA+RNCL    +++
Sbjct: 999  NDKTIEESDEISSKKLTMMALDVARGLSYLAQLKYVHRDVASRNCLINAQRIV 1051


>UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine kinase n=3 Tax=Hydra
           magnipapillata RepID=UPI0001925EBD
          Length = 730

 Score = 94.7 bits (234), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 78/261 (29%), Positives = 129/261 (49%), Gaps = 29/261 (11%)

Query: 11  YYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES- 66
           +Y G++ R      L      G FL+R S    G+   + LS+  E  TS  H+ ++++ 
Sbjct: 100 WYTGVMGRSSANLALLSNGSAGSFLVRKSTSKPGD---YTLSLHNE--TSLKHYHIKKTK 154

Query: 67  DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-WELYHEDVELTK 125
           +   Y+ K  F  +  LV HY           G +   LK A  ++K W++ H  + LTK
Sbjct: 155 NCTFYILKEEFSNLPSLVEHYKKV-------SGGLPRTLKDACSQKKLWDIPHNKITLTK 207

Query: 126 K-LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHI 184
           K LG+G FG V +G+L          V VAVK  K ++   ++ K  ++EA  M+ L H 
Sbjct: 208 KHLGKGNFGIVLEGRLF-------SSVNVAVKVLKTDNCKMKETK-FLKEANNMKELSHK 259

Query: 185 NVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY---QAANGLAYIHE 241
           N++  +GV      +Y+++ELA  GAL   L       +  ++L++   Q ++G+ ++  
Sbjct: 260 NLIHCYGVCYFDSYVYIVLELALHGALHKFLQTSTGQNLTLHDLVHIATQISSGMTHLSH 319

Query: 242 KNLMHRDVAARNCLYGGGQVL 262
             L+HRD+AARN L     V+
Sbjct: 320 IRLLHRDIAARNMLVASKMVI 340


>UniRef50_Q25197 Putative insulin-like peptide receptor n=3 Tax=Eumetazoa
            RepID=HTK7_HYDAT
          Length = 1477

 Score = 93.2 bits (230), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 53/150 (35%), Positives = 92/150 (61%), Gaps = 10/150 (6%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +WEL  E +EL ++LG+G+FG V++G    I D  H  + VAVKT    +   ++I +I+
Sbjct: 1036 EWELNREKIELIRELGQGSFGMVFEGIAHGIGD--HAELRVAVKTTNENASIHDRI-QIL 1092

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-----FPMIKK-- 225
            +EA +M+  +  +VVK  GV +  +P +V+MEL   G L S L +        P++++  
Sbjct: 1093 QEASIMKAFNCNHVVKLIGVVSQGQPTFVVMELMGRGDLKSYLKERRPDDGGIPLMRQEI 1152

Query: 226  YELIYQAANGLAYIHEKNLMHRDVAARNCL 255
            Y+++ + A+G+AY+  +  +H D+AARNC+
Sbjct: 1153 YQMVAEIADGMAYLAARKFVHCDLAARNCM 1182


>UniRef50_UPI000186EE87 tyrosine kinase receptor, putative n=4 Tax=Neoptera
           RepID=UPI000186EE87
          Length = 630

 Score = 93.2 bits (230), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 57/165 (34%), Positives = 86/165 (52%), Gaps = 17/165 (10%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           KWE     +++   LGEG FG+VW+ + L I D      +VAVKT K ES  +++ K+++
Sbjct: 319 KWEFPRHHLKVFNILGEGCFGQVWRCEALNI-DGREGTTVVAVKTLK-ESAGEKERKDLL 376

Query: 173 REARLMRNLD-HINVVKFFGVAAGTEPLYVIMELADGGALDSAL---------GKLH--- 219
           +E  +M++L+ H N+V+  G     +PL+VIME    G L S L         G +H   
Sbjct: 377 QELEVMKSLEPHPNIVRLLGCCTKKDPLFVIMEFVSLGKLQSYLRNSRAERCYGNMHGES 436

Query: 220 --FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                       YQ A G+ ++  K ++HRD+AARN L    QV 
Sbjct: 437 KTLTSRDLTSFAYQCARGMEFLSNKGIIHRDLAARNILVNNDQVC 481


>UniRef50_UPI00017915D5 PREDICTED: similar to tyrosine-protein kinase n=1 Tax=Acyrthosiphon
           pisum RepID=UPI00017915D5
          Length = 1135

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 58/167 (34%), Positives = 89/167 (53%), Gaps = 9/167 (5%)

Query: 99  GTVKAVLKQAVERQKW-ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT 157
           G  +AVL Q  +  +   +  + + LTK+LG GAFGEV++G +  I++   + V   V  
Sbjct: 717 GYQRAVLFQKRDNNELIRIKRKQITLTKRLGSGAFGEVFEGNVKDIIN---EKVEYCVAL 773

Query: 158 AKLESMTKEQI-KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG 216
             L   T + + +E ++EA++M NL H N+++ FGV    EP ++IMEL   G L S L 
Sbjct: 774 KSLNGCTSQYVLEEFLKEAKIMNNLKHKNILRVFGVCLDNEPNFIIMELMKEGDLLSYLR 833

Query: 217 KLHFPMI----KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
           K     I        +    A G +Y+   +L+HRD+AARNCL    
Sbjct: 834 KTRPTQILNRMDYMRMCIDVAEGCSYLKNMHLVHRDLAARNCLVSSS 880


>UniRef50_UPI0001792C07 PREDICTED: similar to tyrosine-protein kinase n=1 Tax=Acyrthosiphon
            pisum RepID=UPI0001792C07
          Length = 1518

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 55/162 (33%), Positives = 95/162 (58%), Gaps = 7/162 (4%)

Query: 99   GTVKAVLKQAVERQKW-ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT 157
            G   AVL Q  ++ +   +  E + LTK+LG GAFGEV++GK+  ++    +   VA+K+
Sbjct: 1128 GYQGAVLFQKKKKNELPSIKREQITLTKRLGSGAFGEVFEGKIKDVVRGECE-TRVAIKS 1186

Query: 158  AKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK 217
             K E  +  +++E ++EA+LM N +H ++++  GV    +P ++IMEL + G L S L K
Sbjct: 1187 LK-EGASHCEVEEFLKEAKLMNNFNHKHILQLIGVCLDNDPNFIIMELMEEGDLLSYLRK 1245

Query: 218  ---LHFPMIKKY-ELIYQAANGLAYIHEKNLMHRDVAARNCL 255
                +   +  Y ++    A G +Y+ + + +HRD+A RNCL
Sbjct: 1246 NRQTNVLNLSDYGQMCIDVAEGCSYLEQMHFIHRDLACRNCL 1287


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score = 92.4 bits (228), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 72/251 (28%), Positives = 125/251 (49%), Gaps = 30/251 (11%)

Query: 24  MLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVY--VDKIGFPTII 81
           M  + G FL+R SE   G    + LSV  + K    H+ ++  D  +Y   ++  F +I 
Sbjct: 298 MCGQDGAFLVRESESTPG---SYSLSVFYQGKL--KHYKIKH-DQDMYRVSERHTFASIS 351

Query: 82  ELVNHY------VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEV 135
           EL+ ++      + T+     +D      +   +   +WEL   ++EL ++LG G FG V
Sbjct: 352 ELIEYHKHNGGGLVTRLRKPVQDANTP--ITAGLGHDRWELDAREIELGRELGSGNFGVV 409

Query: 136 WKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAG 195
             G    +  +N     VA+K  K  SM+++   + + EA++M    H N+V+  GV   
Sbjct: 410 RAG----VYKSNRP---VAIKMMKEGSMSED---DFIAEAQVMMKFRHKNLVELLGVVTS 459

Query: 196 TEPLYVIMELADGGALDSALGKLHFPMIKKYELIY----QAANGLAYIHEKNLMHRDVAA 251
            +P+Y++ EL   G L   L K    +  K ++++    Q A+G+A++ +   +HRD+AA
Sbjct: 460 VKPIYIVTELMSNGNLLDYLKKNQSMLQGKPQILHYMSVQVASGMAFLEDHGFIHRDLAA 519

Query: 252 RNCLYGGGQVL 262
           RNCL G   V+
Sbjct: 520 RNCLVGDNNVV 530


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 82/294 (27%), Positives = 136/294 (46%), Gaps = 57/294 (19%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           K L  + ++ G + R   +++L  P    G FL+R SE   G    F LS+  +   +  
Sbjct: 334 KSLEAEPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPG---TFSLSM--KDGENVR 388

Query: 60  HFVVRESDHKVYVDKIGFPT-----IIELVNHYVSTKESFSTKDGTVKAVLKQAVE---- 110
           HF V++    + +   G P+     +  L+ ++   +   +T   T+K    + +     
Sbjct: 389 HFRVKKVAGGIKLQ--GSPSSPHKDLPSLIKYHKRHRGGLTT---TLKVPCPREIRAPDI 443

Query: 111 ----RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKE 166
               + KWE+  + + L K+LGEG +GEV+KG+     +       VA+KT K  + + E
Sbjct: 444 GYAVKDKWEVDRDTIVLEKQLGEGQYGEVYKGRWNGTTE-------VAIKTLKSAATSAE 496

Query: 167 QIKEIMREARLM-------------RNLDHINVVKFFGVAAGTEPLYVIMELADGGAL-- 211
              E ++EA+LM             R L H N+VK   V    EP+++I EL   G+L  
Sbjct: 497 ---EFLQEAQLMKVRARVGIALARARKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLD 553

Query: 212 ---DSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                A   L  P +   ++    A+G+AY+ E N +HRD+AARN L G   + 
Sbjct: 554 YLRSPAGESLRLPTL--IDMASDVAHGMAYLEENNYIHRDLAARNILVGENNIC 605


>UniRef50_C4XV92 Venus kinase receptor (Fragment) n=6 Tax=Drosophila
           RepID=C4XV92_DROMO
          Length = 1107

 Score = 91.3 bits (225), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 56/164 (34%), Positives = 89/164 (54%), Gaps = 20/164 (12%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           KWE+  ++V + ++LGEGAFG V+ G+    LD++ +   VAVKT K    T++++ + +
Sbjct: 720 KWEVQKDNVVINRRLGEGAFGTVYGGEAR--LDSD-EWTAVAVKTLKAGQSTEDRL-DFL 775

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--------------GKL 218
            EA  M+  +H N++K  GV   TEP+Y IME    G L + L                +
Sbjct: 776 AEAEAMKKFNHKNIIKLLGVCLQTEPIYTIMEFMLYGDLKTYLLARRNMVNEKLTDESDI 835

Query: 219 HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               +  Y +    A+GLAY+ E+  +HRD+A RNCL    +V+
Sbjct: 836 SSKRLTMYAM--DVASGLAYLAEQKYVHRDIACRNCLVNSQRVV 877


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 76/263 (28%), Positives = 126/263 (47%), Gaps = 32/263 (12%)

Query: 9   QKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           + ++HG + R +   +L+   + G FL+R SE   GE   + LSV      S  H+ +++
Sbjct: 300 EAWFHGRISRAEAAALLHVAKQEGCFLVRESESKVGE---YSLSV--SHGDSLRHYHIKK 354

Query: 66  SDHKVYV-DKIGFPTIIELVNHY------VSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
              + Y+ D+  FP I +L+ ++      + T+   S  D    A     +   KWEL  
Sbjct: 355 EGEEFYINDRHRFPDICKLIEYHKLNSGGLVTRLRKSIADLHTPAA--AGLGHGKWELDP 412

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
            D  + ++LG G FG V +   +           VAVK  K  +M+++   + + EA  M
Sbjct: 413 ADFAIGRQLGSGQFGVVHEATYIGEKK-------VAVKMMKQGTMSED---DFISEALAM 462

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK----LHFPMIKKYELIYQAAN 234
           +N  H N+V+ +GV   T P+++I E+   G L   L       H P + +Y +  Q A 
Sbjct: 463 KNFTHPNLVQLYGVCTRTRPMWIITEIMTQGCLLDHLRNNQDLQHRPELLQY-MGVQIAA 521

Query: 235 GLAYIHEKNLMHRDVAARNCLYG 257
            + Y+     +HRD+AARNCL G
Sbjct: 522 AMMYLESLRFIHRDLAARNCLLG 544


>UniRef50_Q17JW1 Tyrosine protein kinase n=2 Tax=Culicini RepID=Q17JW1_AEDAE
          Length = 722

 Score = 90.5 bits (223), Expect = 5e-17,   Method: Compositional matrix adjust.
 Identities = 57/162 (35%), Positives = 88/162 (54%), Gaps = 16/162 (9%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           KWE+  + V + ++LGEGAFG V+ G+  +I D       VAVKT K+ S T++++ + +
Sbjct: 285 KWEVPKDRVVINRRLGEGAFGTVYGGEA-QIGDEGW--TAVAVKTLKIGSTTEDKV-DFL 340

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDS-ALGKLHFPMIKKYE---- 227
            EA  M+  DH N+VK  GV   TEP+Y IME    G L +  L + H    K+ E    
Sbjct: 341 SEAEAMKRFDHNNIVKLLGVCLQTEPVYTIMEFMLYGDLKTYLLARRHLVNSKQSEDSDI 400

Query: 228 -------LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                  +    +  L+Y+ E+  +HRD+A RNC+    +V+
Sbjct: 401 SPKRLTMMALDVSRALSYLAEQKYVHRDLACRNCMVNAQRVV 442


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score = 90.5 bits (223), Expect = 5e-17,   Method: Compositional matrix adjust.
 Identities = 79/266 (29%), Positives = 126/266 (47%), Gaps = 40/266 (15%)

Query: 11  YYHGLLPREDIQEMLNKP--GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDH 68
           ++HG + RED +++L  P  G+FL+R S+   G+   + L V  + +   N+ V R    
Sbjct: 109 WFHGRISREDAEKLLTPPKNGRFLVRESQNYPGD---YTLCVSYDGRVE-NYRVRRNEKG 164

Query: 69  KVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDV------ 121
            V VD    F  +I+LV HY    +   T+       LK  V+++   L+  DV      
Sbjct: 165 LVTVDDDEYFDNLIKLVEHYQKEADGLCTR-------LKAPVDKEGQHLFVVDVNDFKEK 217

Query: 122 -------ELTKK--LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
                   L KK  +G+G FGEVW G        +++   VA+K+ K     ++   + +
Sbjct: 218 GWAIPKASLLKKSLIGKGEFGEVWLG--------DYEGKKVAMKSMKDHLKDEKAKTQFL 269

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQA 232
            EA +M  L H N+V   G++    P+Y+I E    G+L   L      +I K   I  A
Sbjct: 270 AEASVMTTLRHPNLVCLIGISLDDNPIYLITEFMAKGSLIDYLRSRGRAVITKQNQIDFA 329

Query: 233 AN---GLAYIHEKNLMHRDVAARNCL 255
            +   G+ Y+  +N +HRD+AARN L
Sbjct: 330 RDVVKGMVYLESQNFVHRDLAARNVL 355


>UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Suberites domuncula
           RepID=Q7YZX2_SUBDO
          Length = 700

 Score = 90.5 bits (223), Expect = 6e-17,   Method: Compositional matrix adjust.
 Identities = 71/255 (27%), Positives = 120/255 (47%), Gaps = 37/255 (14%)

Query: 19  EDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIGFP 78
           E+I +   + G F++R S      +  + LS+  E +    H  + ES+     +K  FP
Sbjct: 329 ENILKGEGREGGFVVRNSS----RENMYTLSICHEGQVRHYHIKLDESNKYFISEKHRFP 384

Query: 79  TIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK--------WELYHEDVELTKKLGEG 130
           +I EL+ ++        T+    K  ++ A   Q         WE+    + L K+LG G
Sbjct: 385 SIKELIEYHKLNGGGLVTR--LRKPPVQLAPNPQSLGPLFDEAWEIDKVSLSLGKELGSG 442

Query: 131 AFGEV----WKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINV 186
            FG V    WKGK           + VA+K  +  +M ++   + + EA++M+   H N+
Sbjct: 443 QFGRVVSGKWKGK-----------IDVAIKMMREGAMNED---DFIEEAKVMKQFQHENL 488

Query: 187 VKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY----QAANGLAYIHEK 242
           VK +GV     P++++ EL   G L   L +    +++K E+I     Q  + + Y+ E 
Sbjct: 489 VKLYGVCTKNGPIFIVQELMVNGCLLQFL-RQRKELVEKTEIILDMATQICSAMKYLEES 547

Query: 243 NLMHRDVAARNCLYG 257
             +HRD+AARNCL G
Sbjct: 548 GFIHRDLAARNCLVG 562


>UniRef50_A8NM59 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NM59_BRUMA
          Length = 212

 Score = 90.1 bits (222), Expect = 6e-17,   Method: Compositional matrix adjust.
 Identities = 56/160 (35%), Positives = 85/160 (53%), Gaps = 16/160 (10%)

Query: 105 LKQAVERQKWELYHEDVELTKK---LGEGAFGEVWKGKLLKILDANHQPVLVAVKTA--- 158
           L    E+ KW + H++V    +   +G G F +V++GKL          + VA+K     
Sbjct: 6   LVHPFEKPKWFIRHQNVAYNLERGLIGTGNFSDVYEGKLCG-------KISVALKVCHGP 58

Query: 159 KLESMTKEQIKE-IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK 217
             ES+  E  KE ++REA LM    H N+VKFFG+      + VIME   GG+LD+ L  
Sbjct: 59  TGESLNLEDAKEALVREACLMSQFKHPNIVKFFGICYDVPSICVIMEQCTGGSLDNHLQH 118

Query: 218 LHFPMIKKYELIY--QAANGLAYIHEKNLMHRDVAARNCL 255
             + +     ++Y  + A G+ Y+  K+L+HRD+A RNCL
Sbjct: 119 WAYKITIGERILYGLETAKGMCYLQGKDLIHRDLATRNCL 158


>UniRef50_Q52V39 Tyrosine-protein kinase receptor n=3 Tax=Branchiostoma floridae
           RepID=Q52V39_BRAFL
          Length = 797

 Score = 90.1 bits (222), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 55/155 (35%), Positives = 84/155 (54%), Gaps = 19/155 (12%)

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           + +    +LGEGAFG V+ GK  K L  +    LVAVKT K E   ++  K+  REA L+
Sbjct: 508 DTIHFVGELGEGAFGRVYLGKCEK-LKPDEDASLVAVKTLK-EMSVEDARKDFDREAELL 565

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP----------------M 222
            N+ H N+VKF+GV    EP  +I E  + G L++ L + H P                +
Sbjct: 566 TNMQHENIVKFYGVCTEGEPWLMIFEYMENGDLNNYL-RSHGPDAAFLIKNPATHKELSI 624

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
           ++  ++  Q A+G+ Y+  ++ +HRD+A RNCL G
Sbjct: 625 VELLQISVQVASGVEYMASQHFVHRDLATRNCLVG 659


>UniRef50_C5H7S1 Venus kinase receptor n=3 Tax=Culicidae RepID=C5H7S1_ANOGA
          Length = 1465

 Score = 90.1 bits (222), Expect = 7e-17,   Method: Compositional matrix adjust.
 Identities = 55/162 (33%), Positives = 88/162 (54%), Gaps = 16/162 (9%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            KWE+  + V + ++LGEGAFG V+ G+  +I D       VAVKT K+ S T++++ + +
Sbjct: 946  KWEIPKDRVVINRRLGEGAFGTVYGGEA-QIGDEGW--TAVAVKTLKVGSTTEDKV-DFL 1001

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDS-ALGKLHFPMIKKYE---- 227
             EA  M+  DH N+V+  GV   +EP+Y +ME    G L +  L + H    K+ E    
Sbjct: 1002 SEAEAMKRFDHNNIVRLLGVCLQSEPVYTVMEFMLYGDLKTYLLARRHLVNSKQSEDSDI 1061

Query: 228  -------LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                   +    +  L+Y+ E+  +HRDVA RNC+    +V+
Sbjct: 1062 SNKRLTVMALDVSRALSYLAEQKYVHRDVACRNCMVNAQRVV 1103


>UniRef50_B7QM19 Tyrosine-protein kinase receptor n=2 Tax=Ixodes scapularis
            RepID=B7QM19_IXOSC
          Length = 1458

 Score = 90.1 bits (222), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 56/163 (34%), Positives = 86/163 (52%), Gaps = 20/163 (12%)

Query: 110  ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
            E  +WE+  E + L K LG+G+FG V++G L+  L  +      AVKT    +  +E+I 
Sbjct: 1038 EPDEWEVPRESINLVKALGQGSFGMVYEG-LIYNLKPDKPETKCAVKTVNESASMRERI- 1095

Query: 170  EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE-- 227
            E ++EA +M+     +VVK  GV +  +P+YVIMEL   G L S L + H P  +  E  
Sbjct: 1096 EFLQEAAVMKAFSCQHVVKLLGVVSKDQPVYVIMELMSNGDLKSYL-RSHRPPTEGEEDD 1154

Query: 228  ---------------LIYQAANGLAYIHEKNLMHRDVAARNCL 255
                           +  + A+G+AY+     +HRD+AARNC+
Sbjct: 1155 SKPRGQPPSLKQILQMAAEIADGMAYLTASKFVHRDLAARNCM 1197


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score = 89.7 bits (221), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 75/257 (29%), Positives = 128/257 (49%), Gaps = 31/257 (12%)

Query: 11  YYHGLLPREDIQEMLNKP---GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESD 67
           ++HG + RE+ + +L KP   G FL+R S    G+   + L V   +K    H+ ++ ++
Sbjct: 378 WFHGRIKREEAENLL-KPREDGLFLVRESTNFPGD---YTLCVCFNEKVE--HYRIKYAE 431

Query: 68  HKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAV-----ERQKWELYHEDV 121
           +K+ +D    F  + +LV HY    +   TK   +KA+ K+       +   WE+  ED+
Sbjct: 432 NKLTIDDDEYFDNLGQLVEHYTLDSDGLCTK--LMKALPKEEFCVKDFQDNGWEIKMEDL 489

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
           +L + +G+G FG+V    +L IL        VAVK  K       +    + EA +M  L
Sbjct: 490 QLKENIGKGEFGDV----MLGILKGEK----VAVKVLKDAGRASNKF---LAEAGVMTTL 538

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKYELIYQAANGLAY 238
           +H N+VKF G+    + +Y++ E    G+L   L   G+ H     +    +   +G+ Y
Sbjct: 539 EHENLVKFIGLVFHDKYIYLVTEYMSKGSLVDYLRSRGRQHITRRDQINFAFDTCSGMEY 598

Query: 239 IHEKNLMHRDVAARNCL 255
           +  K ++HRD+AARN L
Sbjct: 599 LEMKKVIHRDLAARNVL 615


>UniRef50_P08922 Proto-oncogene tyrosine-protein kinase ROS n=24 Tax=Coelomata
            RepID=ROS_HUMAN
          Length = 2347

 Score = 89.7 bits (221), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 55/145 (37%), Positives = 77/145 (53%), Gaps = 9/145 (6%)

Query: 119  EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
            E + L   LG GAFGEV++G  + IL      + VAVKT K  S  +E+I E ++EA LM
Sbjct: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKI-EFLKEAHLM 2001

Query: 179  RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI--------KKYELIY 230
               +H N++K  GV    EP Y+I+EL +GG L + L K                 +L  
Sbjct: 2002 SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCV 2061

Query: 231  QAANGLAYIHEKNLMHRDVAARNCL 255
              + G  Y+   + +HRD+AARNCL
Sbjct: 2062 DISKGCVYLERMHFIHRDLAARNCL 2086


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score = 89.7 bits (221), Expect = 9e-17,   Method: Compositional matrix adjust.
 Identities = 69/259 (26%), Positives = 116/259 (44%), Gaps = 23/259 (8%)

Query: 10  KYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
           ++Y   + R   +++L    K G F++R S               G+ +    H+VV  +
Sbjct: 280 EWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCST 339

Query: 67  DHKVY--VDKIGFPTIIELVNHY------VSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
               Y   +K  F TI EL+N++      + ++  +        A     +    WE+  
Sbjct: 340 PQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDP 399

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           +D+   K+LG G FG V  GK     D       VA+K  K  SM+++   E + EA++M
Sbjct: 400 KDLTFLKELGTGQFGVVKYGKWRGQYD-------VAIKMIKEGSMSED---EFIEEAKVM 449

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGL 236
            NL H  +V+ +GV     P+++I E    G L + L ++   F   +  E+       +
Sbjct: 450 MNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAM 509

Query: 237 AYIHEKNLMHRDVAARNCL 255
            Y+  K  +HRD+AARNCL
Sbjct: 510 EYLESKQFLHRDLAARNCL 528


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score = 89.7 bits (221), Expect = 9e-17,   Method: Compositional matrix adjust.
 Identities = 71/269 (26%), Positives = 133/269 (49%), Gaps = 32/269 (11%)

Query: 10  KYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSV-VGEKKTSANHFVVRE 65
           ++Y G + R+  + +L   +K G F++R S      K  + LS+     ++   H+ +++
Sbjct: 409 EWYVGDMSRQRAESLLKQGDKEGCFVVRKSS----TKGLYTLSLHTKVPQSHVKHYHIKQ 464

Query: 66  SDHKVYV--DKIGFPTIIELVNHY------VSTKESFSTKDGTVKAVLKQAVERQKWELY 117
           +    Y   +K    TI +L+N++      ++ +   S  D  V       +   KWE++
Sbjct: 465 NARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPT--AGLSHDKWEIH 522

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
             ++ L ++LG G FG V +GK    +D        AVK  K  +M+++   + + EA++
Sbjct: 523 PMELMLMEELGSGQFGVVRRGKWRGSID-------TAVKMMKEGTMSED---DFIEEAKV 572

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKY----ELIYQAA 233
           M  L H N+V+ +GV +   P+Y++ E    G+L + L +    +I       ++  Q +
Sbjct: 573 MTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVS 632

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            G+ Y+   N +HRD+AARNCL G   V+
Sbjct: 633 KGMTYLERHNYIHRDLAARNCLVGSENVV 661


>UniRef50_A8XS61 Putative uncharacterized protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8XS61_CAEBR
          Length = 238

 Score = 89.4 bits (220), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 54/143 (37%), Positives = 73/143 (51%), Gaps = 34/143 (23%)

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           + +  KLGEGAFGEV  G +                                R  + ++ 
Sbjct: 2   ITIQAKLGEGAFGEVAAGTM-----------------------------NFKRRGKTVK- 31

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-FPMIKKYELIYQAANGLAYI 239
              + V +F+GVA   EPLY++MEL   GALDS L K     M K+ E++ Q A GL YI
Sbjct: 32  ---VAVKQFYGVAVMQEPLYLVMELVSNGALDSYLKKNEDLSMEKRVEMLLQVAWGLEYI 88

Query: 240 HEKNLMHRDVAARNCLYGGGQVL 262
           H K ++HRD+AARNCLYG G++ 
Sbjct: 89  HGKPMLHRDIAARNCLYGDGKIC 111


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score = 89.4 bits (220), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 25/260 (9%)

Query: 9   QKYYHGLLPREDIQ---EMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           + +Y G + R + Q   ++ N  G FL+R SE   G    + LSV    +   N+ +  +
Sbjct: 256 EPWYVGKMSRVEAQSKLQIFNLDGTFLVRESETSAG---SYTLSVYFNGQPR-NYRIQHD 311

Query: 66  SDHKVYVDKIGFPTIIELVNHYVSTKESFSTK----DGTVKAVLKQAVERQKWELYHEDV 121
            +      +    TI EL++++        T+        +A     +   KWE+   ++
Sbjct: 312 GNEYYITTRHRQKTIKELIDYHKLNGGGLCTRLKKPACDDEAPTPHDLGSDKWEIDPSEI 371

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
            L K LG G FG V+KGK   + D       VAVK  K  +M ++   E + EA +M+  
Sbjct: 372 SLGKVLGSGQFGVVYKGKFQGVTD-------VAVKKVKGGAMAED---EFIAEAEIMKQF 421

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE-LIY---QAANGLA 237
            H N+V  +GV     PL ++ E    G L + L   +  +  +   L+Y   Q AN + 
Sbjct: 422 KHKNLVNLYGVVTKKRPLMIVTEFMRNGCLLNYLRDHNSELQGRAPVLLYMSIQVANAMV 481

Query: 238 YIHEKNLMHRDVAARNCLYG 257
           ++ E   +HRD+AARNCL G
Sbjct: 482 FLEEHGFIHRDLAARNCLVG 501


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score = 89.4 bits (220), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 78/268 (29%), Positives = 125/268 (46%), Gaps = 34/268 (12%)

Query: 6   LLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    ++HG + R D +++L   K G FL+R S    G+    V S  GE      H+ V
Sbjct: 103 LTAMPWFHGKITRSDAEDLLTPRKDGLFLVRESTNYPGDYTMCV-SFAGE----VEHYRV 157

Query: 64  RESDHKVYVDKIG-FPTIIELVNHY--------VSTKESFSTKDGTVKAVLKQAVERQKW 114
              D+KV +D+   F  + +LV HY         +  +    K G   +V  +   +  W
Sbjct: 158 IFKDNKVTIDEEEYFENLTKLVEHYERDADGLVCTLTQPLIKKGGHEYSVDTEEFRKSGW 217

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
            +   D++L   LG+G FG+V++G         ++   VAVK+ K  S   +  +  + E
Sbjct: 218 AINFTDLKLGTILGKGDFGDVYEG--------TYKDQKVAVKSVKDRS---KAAQAFLAE 266

Query: 175 ARLMRNLDHINVVKFFGV----AAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY 230
           A +M  L H N++K  GV        +P+YV++E    GA+   L      ++   +L  
Sbjct: 267 ASVMTQLHHKNLIKLLGVVIPQTMSNDPIYVVLEFMTKGAMLEYLRSRGRALVTSNDLWK 326

Query: 231 QA---ANGLAYIHEKNLMHRDVAARNCL 255
            A   A G+ Y+  K L+HRD+AARN L
Sbjct: 327 FAKDIALGMEYLENKQLVHRDLAARNIL 354


>UniRef50_Q5MCM8 Protein-tyrosine kinase (Fragment) n=4 Tax=Anthomedusae
           RepID=Q5MCM8_HYDEC
          Length = 1162

 Score = 89.4 bits (220), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 55/149 (36%), Positives = 87/149 (58%), Gaps = 11/149 (7%)

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ-----I 168
           +E+  +D+ L + +G+G FG+V++G     + +   PV  AVKT K+E + KEQ      
Sbjct: 422 YEVARDDLTLDEIIGQGQFGDVYQGTFKSKISSVEIPV--AVKTYKIE-LDKEQEDGTRA 478

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYEL 228
           ++ + EA LM+  DH +V+K  G+ + + P Y+IMELA  G L S L +       +  L
Sbjct: 479 EKFLEEAYLMQQFDHPHVIKLIGIVSDS-PSYIIMELASYGELRSYLQQYRTQTESERLL 537

Query: 229 --IYQAANGLAYIHEKNLMHRDVAARNCL 255
             IYQ +  L+Y+  +N +HRD+AARN L
Sbjct: 538 TYIYQLSTALSYLESRNFVHRDIAARNIL 566


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score = 89.0 bits (219), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 72/261 (27%), Positives = 130/261 (49%), Gaps = 35/261 (13%)

Query: 11  YYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDH 68
           ++HG + R++ + +L   + G FL+R S    G+   + L V  + K    H+ V+  ++
Sbjct: 684 WFHGSITRDEAEHLLQPREDGLFLVRESTNFPGD---YTLCVCFQSKVE--HYRVKYLEN 738

Query: 69  KVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER----------QKWELY 117
           K+ +D +  F  + +LV HY +  +   T+   +K + K   +           + W + 
Sbjct: 739 KLTIDDEEYFENLGQLVAHYEADADGLCTQ--LIKCLPKLGKQEFCINSKDFVDKGWVIP 796

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
             +++L + +G+G FG+V  G L      N +   VAVK  K E      +++ + EA +
Sbjct: 797 EAELQLRESIGKGEFGDVMLGIL-----RNEK---VAVKMLKDEG----AVQKFLAEASV 844

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKYELIYQAAN 234
           M  L+H N+VKF G+   ++ LY++ E    G+L   L   G+ H     +    Y  A+
Sbjct: 845 MTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTAS 904

Query: 235 GLAYIHEKNLMHRDVAARNCL 255
           G+ Y+  K ++HRD+AARN L
Sbjct: 905 GMEYLEAKKVVHRDLAARNVL 925


>UniRef50_UPI0001791F4A PREDICTED: similar to AGAP011648-PA n=1 Tax=Acyrthosiphon pisum
           RepID=UPI0001791F4A
          Length = 701

 Score = 88.6 bits (218), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 57/160 (35%), Positives = 91/160 (56%), Gaps = 16/160 (10%)

Query: 110 ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
           E   WE+    V +   LGEG+FG+VWK +   ++      ++VAVKT K  +  +E++ 
Sbjct: 387 EGDPWEIPRHHVRVCSILGEGSFGQVWKCEAYNVMGFKGN-MVVAVKTLKDNAGERERL- 444

Query: 170 EIMREARLMRNLD-HINVVKFFGVAAGTEPLYVIMELADGGALDSAL---------GKLH 219
           ++++E ++M++L+ H +VVK  G  +  +PL+VIME A  G L S L            H
Sbjct: 445 DLVQELQVMKSLEPHPHVVKLLGCCSERDPLFVIMEYAKLGKLQSVLRNSRGANYYTNTH 504

Query: 220 FP-MIKKYELI---YQAANGLAYIHEKNLMHRDVAARNCL 255
            P  +  +ELI   YQ A G+ ++  K ++HRD+AARN L
Sbjct: 505 GPSSLTSHELIMFCYQIAKGMDFLSSKGIIHRDLAARNIL 544


>UniRef50_C4XV89 Venus kinase receptor (Fragment) n=2 Tax=Pediculus humanus corporis
           RepID=C4XV89_9NEOP
          Length = 1154

 Score = 88.6 bits (218), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 55/173 (31%), Positives = 89/173 (51%), Gaps = 18/173 (10%)

Query: 104 VLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESM 163
           +L   ++  KWE+  + + + +KLGEGAFG V+ G+      ++   V  AVK  K+ S 
Sbjct: 830 LLAPNLDSDKWEIPRDRLVINRKLGEGAFGTVYGGEAYF---SDKGWVAAAVKALKVNST 886

Query: 164 TKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDS-ALGKLHFPM 222
           T++++ + + EA +M+  DH N+VK  GV    EP+Y +ME    G L +  L + H   
Sbjct: 887 TEQKL-DFLSEAEVMKKFDHKNIVKLLGVCTKQEPVYTVMEFMLYGDLKTFLLARRHLVN 945

Query: 223 IKKY-------------ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            KK               +    A GL+Y+ +   +HRD+A RNCL    +V+
Sbjct: 946 NKKIHEESDEISSKKLTAMALDVARGLSYLAQLKYVHRDIACRNCLINYARVV 998


>UniRef50_UPI00004D86FC Tyrosine-protein kinase Tec (EC 2.7.10.2). n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=UPI00004D86FC
          Length = 647

 Score = 88.6 bits (218), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 70/257 (27%), Positives = 121/257 (47%), Gaps = 24/257 (9%)

Query: 20  DIQ-EML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDH--KVYV-D 73
           DIQ +ML  +K G F++R S               GE  T   H+ ++E+ +  K Y+ +
Sbjct: 299 DIQMQMLQIDKEGGFIVRNSSQAGLYTVSLYTKYGGEGSTCIRHYHIKETQYPKKYYLAE 358

Query: 74  KIGFPTIIELVNHY------VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKL 127
           K  F TI E++ ++      + T+  +        A         KWE+   ++   K+L
Sbjct: 359 KHVFNTIPEMIEYHKHNAAGLVTRLRYPVCSKNKSAPTTAGFSYDKWEINPSELTFMKEL 418

Query: 128 GEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVV 187
           G G FG V  GK      A ++   VA+K  +  +M++E   + + EA++M  L H+ +V
Sbjct: 419 GSGLFGVVRLGKW----RAQYK---VAIKAIREGAMSEE---DFIEEAKVMMKLTHLKLV 468

Query: 188 KFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLM 245
           + +GV     P+Y++ E  + G L + L + H  F       +       ++Y+ + N +
Sbjct: 469 QLYGVCTQQRPIYIVTEFMEHGCLLNYLRQRHGQFSPDILLSMCQDVCEAMSYLEQNNFI 528

Query: 246 HRDVAARNCLYGGGQVL 262
           HRD+AARNCL     V+
Sbjct: 529 HRDLAARNCLVNDAGVV 545


>UniRef50_UPI00004D7E5F Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1)
           (C- mer) (Receptor tyrosine kinase MerTK). n=2
           Tax=Euteleostomi RepID=UPI00004D7E5F
          Length = 763

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 51/147 (34%), Positives = 78/147 (53%), Gaps = 15/147 (10%)

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           + L K LGEG FG V +G+L      NH+   VAVKT K+++ ++ +I+E + EA  M++
Sbjct: 471 LNLGKVLGEGEFGSVMEGELQYSDGTNHK---VAVKTMKMDNFSQREIEEFLSEAACMKD 527

Query: 181 LDHINVVKFFGVAAGTEP-----LYVIMELADGGALDSAL-------GKLHFPMIKKYEL 228
            +H NV++  GV     P       VI+     G L S L       G  H P+    + 
Sbjct: 528 FNHPNVIRLLGVCLEVGPRRIPKPMVILPFMKYGDLHSFLLSSRIGSGPQHVPLRTLVKF 587

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCL 255
           +   A G+ Y+  +N +HRD+AARNC+
Sbjct: 588 MIDIATGMEYLSSRNFLHRDLAARNCM 614


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 73/262 (27%), Positives = 131/262 (50%), Gaps = 29/262 (11%)

Query: 9   QKYYHGLLPRED----IQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF-VV 63
           + ++ G + R +    +Q   N  G FL+R SE    +   +VLSV      +  H+ + 
Sbjct: 76  EPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSAD---YVLSV--RDTQAVRHYKIW 130

Query: 64  RESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER----QKWELYH 118
           R +  ++++++ + F ++ ELVN++ +  +S S          K   E       WE   
Sbjct: 131 RRAGGRLHLNEAVSFLSLPELVNYHRA--QSLSHGLRLAAPCRKHEPEPLPHWDDWERPR 188

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           E+  L +KLG G FGEV++G L K        V VA+K    +++  +Q+  +  E + M
Sbjct: 189 EEFTLCRKLGSGYFGEVFEG-LWK------DRVQVAIKVISRDNLLHQQM--LQSEIQAM 239

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIYQAANG 235
           + L H +++  + V +  +P+Y+I EL   G+L   L        P+ +  ++ +Q A G
Sbjct: 240 KKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEG 299

Query: 236 LAYIHEKNLMHRDVAARNCLYG 257
           + Y+  +N +HRD+AARN L G
Sbjct: 300 MCYLESQNYIHRDLAARNILVG 321


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 77/273 (28%), Positives = 122/273 (44%), Gaps = 39/273 (14%)

Query: 11  YYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
           ++ G + R   ++ LN P    G FL+R SE   G   Q+ LS+      +  H+ V   
Sbjct: 237 WFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPG---QYSLSL--RDGDTVRHYRVENY 291

Query: 67  DHKVY----VDKIGFPTIIELVNHYVSTKESFST--KDGTVKAVLKQAVE-----RQKWE 115
           +  +Y         F ++ EL+  +   K   +T  ++   K     A +       +WE
Sbjct: 292 EGGLYKLQGSPTQKFASLPELIAFHGQRKAGLATALREPCPKESAPMASDLTFDTHDQWE 351

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +    ++L K LG G +GEV+ G              VAVKT K  S      K+ + EA
Sbjct: 352 VPRTSIKLGKLLGTGQYGEVYSGIF-------QDSTKVAVKTLKAASANP---KDFLAEA 401

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGAL------DSALGKLHFPMIKKYELI 229
            +M+ L H+N+V    V +   P+ +I+EL   G+L      D A  +L  P +   ++ 
Sbjct: 402 TIMKKLRHLNIVSLLAVCSVGSPILIIVELLSKGSLLDFLRSDDA-KELRIPNL--VDMG 458

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            Q A G+AY+     +HRD+AARN L G   V 
Sbjct: 459 AQVAAGMAYLESMKFIHRDLAARNVLVGDNNVC 491


>UniRef50_P34152 Focal adhesion kinase 1 n=16 Tax=Eutheria RepID=FAK1_MOUSE
          Length = 1090

 Score = 88.2 bits (217), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 58/163 (35%), Positives = 86/163 (52%), Gaps = 23/163 (14%)

Query: 110 ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVL-VAVKTAKLESMTKEQI 168
           E + +E+  E +EL + +GEG FG+V +G  L    +   P L VA+KT K  + T + +
Sbjct: 449 EARDYEIQRERIELGRCIGEGQFGDVHQGVYL----SPENPALAVAIKTCK--NCTSDSV 502

Query: 169 KE-IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE 227
           +E  ++EA  MR  DH ++VK  GV     P+++IMEL   G L S      F  ++KY 
Sbjct: 503 REKFLQEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRS------FLQVRKYS 555

Query: 228 L--------IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L         YQ +  LAY+  K  +HRD+AARN L      +
Sbjct: 556 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCV 598


>UniRef50_B7P3J2 Leukocyte tyrosine kinase receptor, putative n=1 Tax=Ixodes
           scapularis RepID=B7P3J2_IXOSC
          Length = 662

 Score = 87.8 bits (216), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 61/175 (34%), Positives = 88/175 (50%), Gaps = 28/175 (16%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLK--ILDANHQPV--------------LVAVKTA 158
           ++  E++ L K LG+GAFGEV++G LL   +  +   PV               VAVKT 
Sbjct: 305 DIPRENLTLVKALGQGAFGEVYQGFLLPAAVPTSPTSPVSEGAPPLASAAADVPVAVKTL 364

Query: 159 KLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--- 215
             E  + E  K+ + EA +M   +H N+V+F GV     P ++++EL  GG L S L   
Sbjct: 365 P-ELSSPESEKDFVTEACIMSKFNHPNIVRFIGVCFEKMPRFIVLELLAGGDLKSFLRES 423

Query: 216 -GKLHFP----MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLY---GGGQVL 262
             K   P    M     L    A G  Y+ +K+ +HRD+AARNCL    G G+V+
Sbjct: 424 RPKPSIPPSLTMTDLLNLAIDVAKGCQYLEDKHFIHRDIAARNCLLTTKGPGRVV 478


>UniRef50_UPI0000DB6DD4 PREDICTED: similar to Insulin-like growth factor 1 receptor
           precursor (Insulin-like growth factor I receptor) (IGF-I
           receptor) n=1 Tax=Apis mellifera RepID=UPI0000DB6DD4
          Length = 855

 Score = 87.4 bits (215), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 53/153 (34%), Positives = 83/153 (54%), Gaps = 13/153 (8%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WE+  E +E+ + LG G FG V++G    I+    + V  AVKT   ++  +E+I E +
Sbjct: 322 EWEVPREKIEMLRSLGTGTFGMVYEGIAKDIVKGKSE-VRCAVKTVNKDATDRERI-EFL 379

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP----------M 222
            EA +M+  D  +VVK  GV    +P  VIMEL   G L   L + H P          +
Sbjct: 380 NEASVMKGFDAHHVVKLLGVVTRGQPTLVIMELMVNGDLKRYL-RSHRPCENMSNAPPKL 438

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
            +  ++  + A+G+AY+  K  +HRD+AARNC+
Sbjct: 439 DRILQMAIEIADGMAYLSTKKFVHRDLAARNCM 471


>UniRef50_P00529 Tyrosine-protein kinase transforming protein ros n=12 Tax=root
           RepID=ROS_AVISU
          Length = 402

 Score = 87.4 bits (215), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 55/145 (37%), Positives = 76/145 (52%), Gaps = 9/145 (6%)

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           + + L K LG GAFGEV++G  L IL        VAVKT K    T ++  E ++EA LM
Sbjct: 96  DKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLK-RGATDQEKSEFLKEAHLM 154

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL-----GKLHFP---MIKKYELIY 230
              DH +++K  GV    EP Y+I+EL +GG L S L      K   P   +    ++  
Sbjct: 155 SKFDHPHILKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICL 214

Query: 231 QAANGLAYIHEKNLMHRDVAARNCL 255
               G  Y+ +   +HRD+AARNCL
Sbjct: 215 DICKGCVYLEKMRFIHRDLAARNCL 239


>UniRef50_P06213 Insulin receptor subunit beta n=70 Tax=Euteleostomi RepID=INSR_HUMAN
          Length = 1382

 Score = 87.4 bits (215), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 54/154 (35%), Positives = 84/154 (54%), Gaps = 13/154 (8%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +WE+  E + L ++LG+G+FG V++G    I+    +   VAVKT    +  +E+I E +
Sbjct: 1015 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAE-TRVAVKTVNESASLRERI-EFL 1072

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIK 224
             EA +M+     +VV+  GV +  +P  V+MEL   G L S L  L          P   
Sbjct: 1073 NEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPT 1132

Query: 225  KYELIYQAA---NGLAYIHEKNLMHRDVAARNCL 255
              E+I  AA   +G+AY++ K  +HRD+AARNC+
Sbjct: 1133 LQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCM 1166


>UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona intestinalis
           RepID=UPI000180C4F3
          Length = 512

 Score = 87.4 bits (215), Expect = 5e-16,   Method: Compositional matrix adjust.
 Identities = 73/260 (28%), Positives = 123/260 (47%), Gaps = 37/260 (14%)

Query: 21  IQEMLNKPGQFLLR--TSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVY-VDK-IG 76
           + +  N  G FL R  T+ P      ++ LSV      + NH  + +   + Y +D    
Sbjct: 145 LMQPCNNHGDFLARRRTTNP-----NEYALSV--RNGATVNHIKIEKMGGQGYSIDHHTM 197

Query: 77  FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ------------KWELYHEDVELT 124
           F T+ +LV +Y   +E+    D  +++  KQ V               +WE+  + +EL 
Sbjct: 198 FATLNDLVGYY---QENMLANDIRLRSPCKQVVMESPQTAGLSHDLADEWEIDRKSIELK 254

Query: 125 KKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHI 184
           +KLG+G FGEV+KG        N    +   K  K + + KE   E ++EA++M+ L H 
Sbjct: 255 EKLGKGNFGEVYKGLW------NGTTRVAVKKMIKSDLLDKE---EFLKEAKIMKKLHHP 305

Query: 185 NVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK--YELIYQAANGLAYIHEK 242
            +V+ + V   +EP Y++ EL   G+L   L +    + +    E+  Q A G+ Y+   
Sbjct: 306 KLVQLYAVCTHSEPFYIVTELMCNGSLREYLREKGKDLNEDTLIEMAIQVATGMVYLEVN 365

Query: 243 NLMHRDVAARNCLYGGGQVL 262
           + +HRD+AARN L G   + 
Sbjct: 366 DYIHRDLAARNILVGKNNIC 385


>UniRef50_Q25410 Putative molluscan insulin-related peptide(s) receptor beta chain n=8
            Tax=Coelomata RepID=MIPR_LYMST
          Length = 1607

 Score = 87.0 bits (214), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 51/154 (33%), Positives = 88/154 (57%), Gaps = 13/154 (8%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +WE+  + ++L K+LG+G+FG V++G    I D  ++ + VAVKT    +   ++ +E +
Sbjct: 1029 EWEVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRASFSDR-REFL 1087

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP----------- 221
            +EA  M+     +VVK  GV +  +P  VIMEL   G L + L + H P           
Sbjct: 1088 KEATTMKEFHCHHVVKLLGVVSTGQPALVIMELMALGDLKNYL-RGHRPDEDHPGVMPPH 1146

Query: 222  MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
            ++   ++  + A+G+AY+ +K  +HRD+AARNC+
Sbjct: 1147 LLDILQMAGEIADGMAYLADKKFVHRDLAARNCM 1180


>UniRef50_B3XVX1 Protein tyrosine kinase syk (Fragment) n=1 Tax=Monosiga ovata
           RepID=B3XVX1_9EUKA
          Length = 835

 Score = 87.0 bits (214), Expect = 6e-16,   Method: Compositional matrix adjust.
 Identities = 84/298 (28%), Positives = 133/298 (44%), Gaps = 63/298 (21%)

Query: 13  HGLLPREDIQEMLN----KPGQFLLR-TSEPVK-----GEKRQFVLSVVGEKKTSANHFV 62
           +GLL R+  + +L     K G +L+R T +P       G    FV+SV+   K    H +
Sbjct: 113 YGLLGRDAAEALLQRLSPKDGSYLVRQTDKPTPDDRFPGAMAHFVVSVL--HKGRGQHLL 170

Query: 63  VRESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTK---------------DGTVKAVL 105
           +R+     Y   D + + T+ ELV+HY   ++    +                G + + +
Sbjct: 171 IRKFPSGKYGIDDGLRYRTLAELVDHYRHGRDGLCCELRENVFLLDQARPNDAGRIISAI 230

Query: 106 KQAVER-----------------------QKWELYHEDVELTKKLGEGAFGEVWKGKLLK 142
           K    +                       +   +  + +  + KLGEG FG V KG L K
Sbjct: 231 KTRFAKLSAAAPAQSRSSSSSSLPKPASLESAVILSKYISTSTKLGEGEFGTVLKGVLTK 290

Query: 143 ILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVI 202
                  P+ VAVK  K+ +       E+ +EA  M NLDH NVV+  GV   +  L ++
Sbjct: 291 ---PGQSPIAVAVKALKIGA----DDNELRKEALTMVNLDHPNVVRMLGVCTDSPTLQLV 343

Query: 203 MELADGGALDSALGKLHFPMIKKYEL---IYQAANGLAYIHEKNLMHRDVAARNCLYG 257
           +EL   GA++S L + H   I+  +L   I Q A G+ Y+   +++HRD+AARN L G
Sbjct: 344 VELLPNGAINSYL-RAHETSIQLGQLMSFITQIAEGMLYLEGMHVIHRDLAARNVLVG 400


>UniRef50_Q05397 Focal adhesion kinase 1 n=105 Tax=cellular organisms
           RepID=FAK1_HUMAN
          Length = 1052

 Score = 86.7 bits (213), Expect = 7e-16,   Method: Compositional matrix adjust.
 Identities = 65/205 (31%), Positives = 98/205 (47%), Gaps = 31/205 (15%)

Query: 76  GFPTIIELVN--------HYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKL 127
             P+I +L N        H VS  E+    +   +         + +E+  E +EL + +
Sbjct: 369 ALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCI 428

Query: 128 GEGAFGEVWKGKLLKILDANHQPVL-VAVKTAKLESMTKEQIKE-IMREARLMRNLDHIN 185
           GEG FG+V +G    I  +   P L VA+KT K  + T + ++E  ++EA  MR  DH +
Sbjct: 429 GEGQFGDVHQG----IYMSPENPALAVAIKTCK--NCTSDSVREKFLQEALTMRQFDHPH 482

Query: 186 VVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYEL--------IYQAANGLA 237
           +VK  GV     P+++IMEL   G L S      F  ++KY L         YQ +  LA
Sbjct: 483 IVKLIGVIT-ENPVWIIMELCTLGELRS------FLQVRKYSLDLASLILYAYQLSTALA 535

Query: 238 YIHEKNLMHRDVAARNCLYGGGQVL 262
           Y+  K  +HRD+AARN L      +
Sbjct: 536 YLESKRFVHRDIAARNVLVSSNDCV 560


>UniRef50_Q9VBW3 Tyrosine kinase receptor Cad96Ca n=14 Tax=Coelomata
           RepID=CAD96_DROME
          Length = 773

 Score = 86.7 bits (213), Expect = 7e-16,   Method: Compositional matrix adjust.
 Identities = 54/158 (34%), Positives = 81/158 (51%), Gaps = 17/158 (10%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WE     ++    LGEGAFG+VW+ +   I + N     VAVKT K ES T+   K+++
Sbjct: 462 RWEFPRYRLKFFNILGEGAFGQVWRCEATNI-NGNEGITTVAVKTLK-ESATEVDRKDLL 519

Query: 173 REARLMRNLD-HINVVKFFGVAAGTEPLYVIMELADGGALDSAL---------GKLH--- 219
            E  +M++L+ HINVV   G     +P +VI+E  + G L + L         G  H   
Sbjct: 520 SELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKS 579

Query: 220 --FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
                      +YQ A G+ Y+  + ++HRD+AARN L
Sbjct: 580 NVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNIL 617


>UniRef50_B3RWF6 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax
           adhaerens RepID=B3RWF6_TRIAD
          Length = 259

 Score = 86.7 bits (213), Expect = 7e-16,   Method: Compositional matrix adjust.
 Identities = 51/158 (32%), Positives = 82/158 (51%), Gaps = 21/158 (13%)

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           +E+   D+++ K+LG G FG V+ G            + VAVK  K +SM++E   + +R
Sbjct: 4   FEINRNDLQIGKQLGRGQFGVVYFGTY-------RNSIEVAVKMLKSDSMSEE---DFLR 53

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE------ 227
           EA++M  L H N+V+ +G+ +  +PL++I E    G L   L + HF             
Sbjct: 54  EAKVMHKLKHENLVQLYGICSIGKPLFIISEFMSRGCLLDYL-REHFSSTTALSSQQTVE 112

Query: 228 ----LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
               +  Q  + + Y+ E N +HRD+AARNCL GG  +
Sbjct: 113 VLLNMALQICSAMLYLEENNFIHRDLAARNCLIGGTNI 150


>UniRef50_P14616 Insulin receptor-related protein beta chain n=11 Tax=Eutheria
            RepID=INSRR_HUMAN
          Length = 1297

 Score = 86.7 bits (213), Expect = 7e-16,   Method: Composition-based stats.
 Identities = 54/154 (35%), Positives = 85/154 (55%), Gaps = 13/154 (8%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +WE+  E + + ++LG+G+FG V++G L + L+A  +   VA+KT    +  +E I E +
Sbjct: 971  EWEVPREQISIIRELGQGSFGMVYEG-LARGLEAGEESTPVALKTVNELASPRECI-EFL 1028

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIK 224
            +EA +M+     +VV+  GV +  +P  VIMEL   G L S L  L          P   
Sbjct: 1029 KEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPA 1088

Query: 225  KYELIYQA---ANGLAYIHEKNLMHRDVAARNCL 255
              E+I  A   A+G+AY+     +HRD+AARNC+
Sbjct: 1089 LGEMIQMAGEIADGMAYLAANKFVHRDLAARNCM 1122


>UniRef50_UPI0000DB7426 PREDICTED: similar to insulin-like growth factor 1 receptor isoform 1
            n=1 Tax=Apis mellifera RepID=UPI0000DB7426
          Length = 1422

 Score = 86.7 bits (213), Expect = 7e-16,   Method: Composition-based stats.
 Identities = 48/148 (32%), Positives = 84/148 (56%), Gaps = 13/148 (8%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +WE+  E VE++ +LG G FG V++G    + D   + + VA+KT    +  +E+  E +
Sbjct: 1083 EWEVPRESVEISNELGLGNFGMVYRG----VYD---KTIPVAIKTISKTASQREK-NEFL 1134

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI-----KKYE 227
             EA +M+N    +++K  GV +   P +VIMEL + G L + L ++    +     +   
Sbjct: 1135 NEASVMKNFSTFHIIKLIGVVSIENPPFVIMELMENGDLKTYLRRIRDTRLVPDTCRIMR 1194

Query: 228  LIYQAANGLAYIHEKNLMHRDVAARNCL 255
            +  + A+G+AY+  K  +HRD+AARNC+
Sbjct: 1195 MAAEIADGMAYLESKKYVHRDLAARNCM 1222


>UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera RepID=SRC64_DROME
          Length = 552

 Score = 86.7 bits (213), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 63/207 (30%), Positives = 99/207 (47%), Gaps = 46/207 (22%)

Query: 86  HYVSTKESFSTKDGTVKAVLKQAVE-----------------------RQKWELYHEDVE 122
           +Y++T ++F +    V A  K A+                        R K+E+   +++
Sbjct: 226 YYIATNQTFPSLQALVMAYSKNALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQ 285

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L +KLG G FGEV+ GK    +D       VAVKT +  +M+       ++EA +M+   
Sbjct: 286 LLRKLGRGNFGEVFYGKWRNSID-------VAVKTLREGTMS---TAAFLQEAAIMKKFR 335

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGK-----LHFPMIKKYELIY---QAAN 234
           H  +V  + V +  EP+Y++ E    G+L   L +     LHF      +LIY   Q A+
Sbjct: 336 HNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFE-----DLIYIATQVAS 390

Query: 235 GLAYIHEKNLMHRDVAARNCLYGGGQV 261
           G+ Y+  K L+HRD+AARN L G   V
Sbjct: 391 GMEYLESKQLIHRDLAARNVLIGENNV 417


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score = 86.7 bits (213), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 60/194 (30%), Positives = 95/194 (48%), Gaps = 24/194 (12%)

Query: 26  NKPGQFLLRTSEPVKGEKRQFVLSV--VGEKKTSANHFVVRESDHKVY--VDKIGFPTII 81
           N  G FL+R SE   G    + LS+           H+ +R  D+  +    KI F ++ 
Sbjct: 135 NTQGSFLVRESETTPG---SYSLSMRDFDNNGDGVKHYRIRNMDNGGFYITTKISFNSLK 191

Query: 82  ELVNHYVSTKESFSTKDGTVKAVLKQAVER----QKWELYHEDVELTKKLGEGAFGEVWK 137
           ELV HY    +   TK   VK    +A ++     +WE+  E ++L +KLG G FGEVW 
Sbjct: 192 ELVQHYSRDSDGLCTK--LVKPCQSKAPQKPWWQDEWEIPRESLKLERKLGAGQFGEVWM 249

Query: 138 GKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE 197
           G         +    VA+K  K+ +M+   ++  + EA +M+NL H  +V+ F V    E
Sbjct: 250 G-------VYNNERRVAIKCLKIGTMS---VEAFLAEANMMKNLQHARLVRLFAVVT-QE 298

Query: 198 PLYVIMELADGGAL 211
           P+Y++ E  + G+L
Sbjct: 299 PIYIVTEYMENGSL 312


>UniRef50_Q2LC18 Tyrosine-protein kinase receptor (Fragment) n=2
           Tax=Strongylocentrotus purpuratus RepID=Q2LC18_STRPU
          Length = 1072

 Score = 86.7 bits (213), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 48/156 (30%), Positives = 87/156 (55%), Gaps = 11/156 (7%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WE   + +E+ ++LG+G+FG V++G    IL    +   VA+K+ +  +  +++I E +
Sbjct: 691 EWEFPRDKLEIIRELGKGSFGMVYEGLAKGILPEEEEISRVAIKSVQANASMRDRI-EFL 749

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL------GKLHFPMIKKY 226
            EA +M+ +D  NVV+  GV +  +P YVIME    G L + L       +   P +   
Sbjct: 750 NEASVMKLIDAHNVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQQDLPSVPTL 809

Query: 227 E----LIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           E    +  + A+G++++  +  +HRD++ARNCL  G
Sbjct: 810 EQLLNMAAEIADGMSFLAARKYVHRDLSARNCLVSG 845


>UniRef50_Q5C5Y5 SJCHGC03615 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5C5Y5_SCHJA
          Length = 327

 Score = 86.7 bits (213), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 55/154 (35%), Positives = 85/154 (55%), Gaps = 9/154 (5%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKG--KLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
           +++E    ++++  +LG GAFG V++G  K L I    ++ + VAVKT K +  T+E + 
Sbjct: 167 ERYEFSRRNLQIVCRLGSGAFGIVYRGTAKNLTIGVKKYEIIEVAVKTLK-DDFTEEDVS 225

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPM------I 223
           E ++E  +M+ L H +V++ +GV        +IME A  G L   L  L          +
Sbjct: 226 EFLKEMDIMKQLHHKHVIELYGVCTENGSPLLIMEYAPYGNLKEYLRHLEIQSNCNKLRL 285

Query: 224 KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
           K  E  YQ ANG+ Y+  K L+HRD+AARN L G
Sbjct: 286 KLLEYGYQVANGMKYLETKCLIHRDLAARNILVG 319


>UniRef50_Q4RM64 Chromosome 10 SCAF15019, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Tetraodontidae RepID=Q4RM64_TETNG
          Length = 410

 Score = 86.3 bits (212), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 53/151 (35%), Positives = 90/151 (59%), Gaps = 14/151 (9%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK-EIMR 173
           E+  +++ L + LG GAFGEV++G+LL  ++ +++P+ VA+KT  L  +  EQ + + + 
Sbjct: 54  EVPRKNITLLRALGHGAFGEVYEGQLLG-MNNDNKPMQVAIKT--LPEICSEQDEMDFLM 110

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP------MIKKYE 227
           EA +M    H N+V+  GV+    P ++++EL  GG + S L + + P      ++   E
Sbjct: 111 EALIMSKFSHENIVRCIGVSLNILPRFILLELMTGGDMKSFL-RQNRPRAGQTSLLSMRE 169

Query: 228 LIYQA---ANGLAYIHEKNLMHRDVAARNCL 255
           L+  A   A G  Y+ E + +HRD+AARNCL
Sbjct: 170 LLQMARDIAFGCRYLEENHFIHRDIAARNCL 200


>UniRef50_UPI0000EC9DFD Insulin receptor related tyrosine kinase n=1 Tax=Gallus gallus
           RepID=UPI0000EC9DFD
          Length = 972

 Score = 85.9 bits (211), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 52/154 (33%), Positives = 87/154 (56%), Gaps = 13/154 (8%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WE+  E + + ++LG+G+FG V++G  + ++ A  +   VA+KT    +  +E+I E +
Sbjct: 637 EWEVSREKITVIRELGQGSFGMVYEGLAMGLV-AEGEETKVALKTVNELATMRERI-EFL 694

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIK 224
           +EA +M+     +VV+  GV +  +P  VIMEL   G L S L  L          P   
Sbjct: 695 KEASVMKAFKCHHVVRLLGVVSQGQPALVIMELMTRGDLKSYLRSLRPDAENNPGLPPPS 754

Query: 225 KYELIYQA---ANGLAYIHEKNLMHRDVAARNCL 255
             ++I  A   A+G+AY++ K  +HRD+AARNC+
Sbjct: 755 LKDMIQMAGEIADGMAYLNAKKFVHRDLAARNCM 788


>UniRef50_UPI000194BA20 PREDICTED: EPH receptor A3 n=2 Tax=Euteleostomi RepID=UPI000194BA20
          Length = 1106

 Score = 85.9 bits (211), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 51/151 (33%), Positives = 88/151 (58%), Gaps = 6/151 (3%)

Query: 107 QAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKE 166
           QAV     EL   ++ + K +G G FGEV  G+L K+   + + + VA+KT K+   T++
Sbjct: 730 QAVHEFAKELDASNISIDKVVGAGEFGEVCSGRL-KL--PSKKEISVAIKTLKV-GYTEK 785

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIK 224
           Q ++ + EA +M   DH N+++  GV   ++P+ ++ E  + G+LDS L K    F +I+
Sbjct: 786 QRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQ 845

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
              ++   A+G+ Y+ +   +HRD+AARN L
Sbjct: 846 LVGMLRGIASGMKYLSDMGYVHRDLAARNIL 876


>UniRef50_B7QAX3 Tyrosine-protein kinase receptor n=1 Tax=Ixodes scapularis
           RepID=B7QAX3_IXOSC
          Length = 711

 Score = 85.9 bits (211), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 51/155 (32%), Positives = 83/155 (53%), Gaps = 17/155 (10%)

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
            E +   + LGEGAFG V+ G +   L  +    LVAVKT K  S+ + ++ +  REA L
Sbjct: 422 REKISFIQSLGEGAFGRVFLGTV-DYLTPDEPTTLVAVKTLKNMSVDEARL-DFDREAEL 479

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL------------GKLHFPMIKK 225
           + NL H N+V+F+G++   +PL ++ E  + G L++ L                 P + +
Sbjct: 480 LTNLQHANIVRFYGISTDGDPLMILFEYMEYGDLNNFLRDRGPDSTVLDPKSKQVPPLSR 539

Query: 226 YELI---YQAANGLAYIHEKNLMHRDVAARNCLYG 257
            +L+    Q A G+ Y+  ++ +HRD+A RNCL G
Sbjct: 540 ADLLKISTQVACGMEYLASQHFVHRDLATRNCLVG 574


>UniRef50_P08069 Insulin-like growth factor 1 receptor beta chain n=67
            Tax=Euteleostomi RepID=IGF1R_HUMAN
          Length = 1367

 Score = 85.9 bits (211), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 50/154 (32%), Positives = 86/154 (55%), Gaps = 13/154 (8%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +WE+  E + ++++LG+G+FG V++G + K +  +     VA+KT    +  +E+I E +
Sbjct: 991  EWEVAREKITMSRELGQGSFGMVYEG-VAKGVVKDEPETRVAIKTVNEAASMRERI-EFL 1048

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPM---------- 222
             EA +M+  +  +VV+  GV +  +P  VIMEL   G L S L  L   M          
Sbjct: 1049 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS 1108

Query: 223  -IKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
              K  ++  + A+G+AY++    +HRD+AARNC+
Sbjct: 1109 LSKMIQMAGEIADGMAYLNANKFVHRDLAARNCM 1142


>UniRef50_UPI000155484B PREDICTED: similar to type 1 IGF receptor n=1 Tax=Ornithorhynchus
           anatinus RepID=UPI000155484B
          Length = 1055

 Score = 85.5 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 51/155 (32%), Positives = 87/155 (56%), Gaps = 14/155 (9%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WE+  E + + ++LG+G+FG V++G + K +  +     VA+KT    +  +E+I E +
Sbjct: 683 EWEVPREKITMCRELGQGSFGMVYEG-IAKGVVKDEPETRVAIKTVNESASMRERI-EFL 740

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHF-----------P 221
            EA +M+  +  +VV+  GV +  +P  VIMEL   G L S L  L             P
Sbjct: 741 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTEQNNPGQAPP 800

Query: 222 MIKKY-ELIYQAANGLAYIHEKNLMHRDVAARNCL 255
            +KK  ++  + A+G+AY++    +HRD+AARNC+
Sbjct: 801 TLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCM 835


>UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7QBP3_IXOSC
          Length = 626

 Score = 85.1 bits (209), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 75/287 (26%), Positives = 128/287 (44%), Gaps = 53/287 (18%)

Query: 6   LLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGEK-KTSANHF 61
           L   ++Y G + R+  +++L    K G F++R S      +  F LS++      S    
Sbjct: 239 LWQHEWYAGDMSRQRAEQVLRQETKEGAFVVRNS----STQGFFTLSLLANSIMNSWASS 294

Query: 62  VVRESDHKVYVDKIGFPTIIELVNHYVST-------------KESFSTKDGTVKAVLKQA 108
           + +   HK+        T   L NH +S                 +  ++   +      
Sbjct: 295 LFKSLRHKIEATDQYLETSYAL-NHAMSIMVFERRGKDCLFRNSCYYCQNSCCQPDSTNN 353

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
               KWE+   ++ L ++LG G FG V +GK     D       VAVK  K  +M+++  
Sbjct: 354 PSLDKWEIDPSELALLEELGSGQFGVVRRGKWRGCRD-------VAVKMMKEGTMSED-- 404

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE- 227
            + + EA+LM  L H N+V+ +GV +   P++++ E    G+L      LHF  ++++E 
Sbjct: 405 -DFIEEAKLMTKLQHPNLVQLYGVCSKHRPIFIVAEYMKHGSL------LHF--LRRHEK 455

Query: 228 ------------LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                       +  Q A+G+AY+   N +HRD+AARNCL G   V+
Sbjct: 456 ALSERGPLLLLDVCLQVASGMAYLELHNYIHRDLAARNCLVGENYVV 502


>UniRef50_Q9GRH1 Tyrosine-protein kinase receptor n=4 Tax=Porifera
           RepID=Q9GRH1_9METZ
          Length = 614

 Score = 85.1 bits (209), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 57/179 (31%), Positives = 92/179 (51%), Gaps = 26/179 (14%)

Query: 105 LKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT-AKLESM 163
           L++ VE   WEL  + + + K++GEGAFG+V++G L  I D +   + VA+KT +  E++
Sbjct: 227 LEEYVEDPAWELVPDSLTMVKEVGEGAFGKVYEGVLATIEDGD---LTVAIKTLSTCENV 283

Query: 164 TKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---- 219
              Q    + EA +M+  D   V++ FG+ +      V+ME    G L   L K      
Sbjct: 284 A--QRNAFLGEASIMKKFDCPYVMRLFGLVSTVNKPLVVMEFMAEGDLRGYLMKCRPQEE 341

Query: 220 ---------------FPMIKKYEL-IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                           P + +++L   Q A G+A++HEK+ +HRD+AARNC+     VL
Sbjct: 342 QFATRFSGSSQSTSKAPSVDQFKLWALQLAKGMAHVHEKHFVHRDLAARNCMIATNLVL 400


>UniRef50_Q7Q0F6 Tyrosine-protein kinase receptor n=1 Tax=Anopheles gambiae
            RepID=Q7Q0F6_ANOGA
          Length = 1318

 Score = 85.1 bits (209), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 18/157 (11%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +WE+  E +   ++LG+G+FG V+KG + K+   N   V  A+KT   E+ T+ +    +
Sbjct: 985  EWEVPREHIIQLEELGQGSFGMVYKGIMTKL--GNDVNVPCAIKTVT-ENATERERDSFL 1041

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP----------- 221
             EA +M+     +VV+ +GV +  +P  VIMEL   G L S L + H P           
Sbjct: 1042 IEATIMKEFHTHHVVRLYGVVSVGQPTLVIMELMANGDLKSYL-RRHRPDYENGEESSPQ 1100

Query: 222  ---MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
               + + Y++  + A+G+AY+  K  +HRD+AARNC+
Sbjct: 1101 PPTLKQIYQMAIEIADGMAYLAAKKFVHRDLAARNCM 1137


>UniRef50_UPI0001757DA5 PREDICTED: similar to insulin receptor, partial n=1 Tax=Tribolium
            castaneum RepID=UPI0001757DA5
          Length = 1450

 Score = 85.1 bits (209), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 66/253 (26%), Positives = 114/253 (45%), Gaps = 37/253 (14%)

Query: 27   KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIGFPTIIELVNH 86
             PG + +R S    G+   F         +   +F + E     YV  I    I+ ++  
Sbjct: 985  SPGNYSVRVSATTSGDYANF---------SPYAYFYIEERPSNTYVTLIVCMLILVIILA 1035

Query: 87   YVS---------TKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWK 137
              +          KES           +       +WE+  + +EL ++LG+G+FG V++
Sbjct: 1036 LCAFCFYKKKKADKESMRLIPSVNPEYVPSVYVPDEWEVPRKKIELIRELGQGSFGMVYE 1095

Query: 138  GKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE 197
            G + + +    Q +  AVKT    +  +E++ E + EA +M+  D  +VV+  GV +  +
Sbjct: 1096 G-IAQDVRGKAQ-IKCAVKTVNEHATNRERL-EFLNEASVMKAFDTAHVVRLLGVVSQGQ 1152

Query: 198  PLYVIMELADGGALDSALGKLHFPMIKKYE---------------LIYQAANGLAYIHEK 242
            P  VIMEL   G L + L + H P  + Y+               +  + A+G+AY+  K
Sbjct: 1153 PTLVIMELMANGDLKTYL-RSHRPDAEVYDPATAKQPPTLKQILQMAIEIADGMAYLSAK 1211

Query: 243  NLMHRDVAARNCL 255
              +HRD+AARNC+
Sbjct: 1212 KFVHRDLAARNCM 1224


>UniRef50_UPI0001927441 PREDICTED: similar to cDNA sequence BC021891 n=2 Tax=Hydra
           magnipapillata RepID=UPI0001927441
          Length = 612

 Score = 85.1 bits (209), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 50/141 (35%), Positives = 80/141 (56%), Gaps = 9/141 (6%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           ++ +E++EL KK+G G FGEV+   L K  DA     +VAVK  +L+ ++K ++K+  +E
Sbjct: 333 DVAYEELELIKKIGSGGFGEVY---LSKWKDA-----IVAVKKLRLQRISKNRLKDFTKE 384

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAAN 234
                 L+H NVVKF G    T  L +IME  D    ++ +  + F   ++ ++I Q   
Sbjct: 385 VTNYYTLNHPNVVKFLGACTVTPNLCIIMEYMDMSLFEAKI-DIDFSEEERLKIISQVCK 443

Query: 235 GLAYIHEKNLMHRDVAARNCL 255
           GL Y+HEK + H D+  +N L
Sbjct: 444 GLLYLHEKGIAHCDLKTQNIL 464


>UniRef50_A9V908 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V908_MONBE
          Length = 1591

 Score = 84.7 bits (208), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 76/267 (28%), Positives = 109/267 (40%), Gaps = 32/267 (11%)

Query: 20   DIQEMLNKP---------GQFLLRTSEPVKGEKRQFV-LSVVGEKKTSAN---------- 59
            D  E L KP         G  L R + P  G KR    +S +     SAN          
Sbjct: 1042 DALEGLTKPPIPAHVVGAGPLLFRPTTPPDGAKRTVSRMSNMTASLRSANLPQQRELARM 1101

Query: 60   HFVVRESDHKVYVDKIGF----PTIIELVNHYVSTKESFS---TKDGTVKAVLKQAVERQ 112
               V      +  D  G     P ++  ++H  S + +      +D      L+Q     
Sbjct: 1102 QAAVSPVSSSINDDSDGIEYETPGVLRGLSHKDSVRNAHDMRRVRDRAADVQLQQLRRAS 1161

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
               L   +V+    LG G FG V + +L +      Q  LVAVK  K  S + EQ    +
Sbjct: 1162 SSMLNGSNVKFLDDLGRGEFGVVRRARLRR----GSQEDLVAVKLLK-HSASVEQEIAFL 1216

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQA 232
             EA +M    H NV++         P+ +++EL + G+L   L       I+K +  Y  
Sbjct: 1217 EEATIMTYFSHQNVLRLVDTVTNERPIMLVLELMEQGSLQRVLRHETMEDIRKLKYSYDI 1276

Query: 233  ANGLAYIHEKNLMHRDVAARNCLYGGG 259
             NGL YIHE+  +HRD+AARN L G G
Sbjct: 1277 LNGLQYIHEEGFIHRDLAARNVLLGQG 1303


>UniRef50_Q4RVA1 Chromosome 15 SCAF14992, whole genome shotgun sequence n=1
           Tax=Tetraodon nigroviridis RepID=Q4RVA1_TETNG
          Length = 885

 Score = 84.7 bits (208), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 50/151 (33%), Positives = 86/151 (56%), Gaps = 6/151 (3%)

Query: 107 QAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKE 166
           +AV     E+    V++ + +G G FGEV+KG+L K+     + + VA+KT K     ++
Sbjct: 407 EAVREFAKEIDVSTVKIEEVIGAGEFGEVYKGRL-KL--PGKREIYVAIKTLK-SGYVEK 462

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIK 224
           Q ++ + EA +M   DH N+++  GV   + P+ ++ E  + GALDS L +    F +I+
Sbjct: 463 QRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEFMENGALDSFLRQNDGQFTVIQ 522

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
              ++   + G+ Y+ E N +HRD+AARN L
Sbjct: 523 LVGMMRGISAGMKYLSEMNYVHRDLAARNIL 553


>UniRef50_B4JP34 GH13860 n=4 Tax=Diptera RepID=B4JP34_DROGR
          Length = 1129

 Score = 84.7 bits (208), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 51/150 (34%), Positives = 82/150 (54%), Gaps = 10/150 (6%)

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           +DVE  ++LGEGAFG+V+KG+L +    N + V VA+K  K  +  K Q ++  RE  L+
Sbjct: 851 QDVEFFEELGEGAFGKVYKGQLTQ---TNKKVVNVAIKALKENASVKTQ-QDFRREIELI 906

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGAL------DSALGKLHFPMIKKYELIYQA 232
            +L H N+V   GV    EP  ++ E    G L      +S + K     ++  ++  Q 
Sbjct: 907 SDLKHQNIVCILGVILNKEPFCMLFEYMANGDLHEFLISNSPVEKKSLLQLEFLQIAMQI 966

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + G+ Y+   + +HRD+AARNCL   G ++
Sbjct: 967 SEGMEYLSGHHYVHRDLAARNCLVNEGLIV 996


>UniRef50_Q4SP88 Ephrin receptor (Fragment) n=4 Tax=Euteleostomi RepID=Q4SP88_TETNG
          Length = 950

 Score = 84.7 bits (208), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 49/137 (35%), Positives = 79/137 (57%), Gaps = 6/137 (4%)

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V++ + +G G FGEV +G+L +   A  + ++VA+KT K    T+ Q ++ + EA +M  
Sbjct: 636 VKIEEVIGAGEFGEVCRGRLKQ---AGRREMVVAIKTLK-AGYTERQRRDFLAEASIMGQ 691

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDS--ALGKLHFPMIKKYELIYQAANGLAY 238
            DH NV++  GV   + P+ +I E  + GALDS   L    F M +   ++   A G+ Y
Sbjct: 692 FDHPNVIRLEGVLTRSCPVLIITEFMENGALDSFLRLNDGRFTMTQLVGMLRGVAAGMKY 751

Query: 239 IHEKNLMHRDVAARNCL 255
           + + N +HRD+AARN L
Sbjct: 752 LSDMNYVHRDLAARNIL 768


>UniRef50_Q21299 Protein W08D2.8, partially confirmed by transcript evidence n=2
           Tax=Caenorhabditis RepID=Q21299_CAEEL
          Length = 543

 Score = 84.7 bits (208), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 69/256 (26%), Positives = 122/256 (47%), Gaps = 20/256 (7%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           LL + +YHG++  +  +++L     +++R S    G   +F L +    +    HF    
Sbjct: 67  LLQRNWYHGMMFGKAAEKLLKWESSYIVRRS---MGPTHKF-LCITARVEDKYFHFQFNW 122

Query: 66  SDHKVYVDKI--GFPTI-IELVNHYVSTKESFSTKDGTVKAVLKQ--AVERQKWELYHED 120
           +        +   FP I ++   H     +++S        V+ Q   + R    L H  
Sbjct: 123 NSEGWSCPILYEKFPRIPVKRYEHIYQLLDAWSL-------VVNQLVPISRCSMILQHSS 175

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           + L  +LG GAFGEV K K + +      P  VAVK   +    + Q+ +   EA +M  
Sbjct: 176 IALENQLGRGAFGEVIKAKYVPM--GATVPTEVAVKRL-IGDAKRPQLVDFCNEANIMTL 232

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYI 239
           L+H N+V  +G A+  +P+ +++E   GG L   L +  + P  +  +   + A+G+ ++
Sbjct: 233 LEHKNIVALYGFASLQQPIMLVIEFVPGGDLRKYLQRTPNVPSKQIIKFAMEIASGMKHL 292

Query: 240 HEKNLMHRDVAARNCL 255
             KN++HRD+AARNCL
Sbjct: 293 SSKNVIHRDLAARNCL 308


>UniRef50_C5H7S0 Venus kinase receptor (Fragment) n=2 Tax=Apis mellifera
            RepID=C5H7S0_APIME
          Length = 1238

 Score = 84.3 bits (207), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 52/163 (31%), Positives = 83/163 (50%), Gaps = 17/163 (10%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            KWE+    V + +KLGEGAFG V+ G+           + VAVKT K+ S T+E++ + +
Sbjct: 869  KWEIPRHRVVINRKLGEGAFGTVYGGEAFF---PEKGWLAVAVKTLKIGSSTEEKL-DFL 924

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDS-ALGKLHFPMIKKYE---- 227
             E  +M+  +H N++K  GV   +EP+  +ME    G L +  L + H      YE    
Sbjct: 925  SEVEVMKQFEHKNIIKLLGVCIKSEPVLTVMEFMLYGDLKTYLLARRHLVNDNSYEDSDE 984

Query: 228  --------LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                    +    A  L+Y+ +   +HRD+A+RNCL    +V+
Sbjct: 985  ISNKKLTAMALDVARALSYLAQSKYVHRDIASRNCLVNAQRVV 1027


>UniRef50_Q4T272 Chromosome undetermined SCAF10323, whole genome shotgun sequence.
           (Fragment) n=2 Tax=Tetraodontidae RepID=Q4T272_TETNG
          Length = 815

 Score = 84.3 bits (207), Expect = 4e-15,   Method: Composition-based stats.
 Identities = 49/154 (31%), Positives = 86/154 (55%), Gaps = 6/154 (3%)

Query: 107 QAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKE 166
           QAV +   E++   + + + +G G FGEV  G L        + +LVA+KT K    T++
Sbjct: 464 QAVHQFAQEIHLSSISIERIIGAGEFGEVCSGPLRL---PGKREILVAIKTLK-AGYTEQ 519

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIK 224
           Q ++ + EA +M   +H N+++  GV   ++P+ +I E  + G+LD+ L K    F +I+
Sbjct: 520 QRRDFLWEASIMGQFNHPNIIRLEGVVTKSKPVMIITEYMENGSLDTFLKKNDGQFTVIQ 579

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
              ++   A+G+ Y+ +   +HRD+AARN L  G
Sbjct: 580 LVGMLRGIASGMRYLSDMGYVHRDLAARNILVDG 613


>UniRef50_Q9U5A8 Tyrosine-protein kinase receptor n=4 Tax=Coelomata RepID=Q9U5A8_BOMMO
          Length = 1472

 Score = 84.3 bits (207), Expect = 4e-15,   Method: Composition-based stats.
 Identities = 46/160 (28%), Positives = 84/160 (52%), Gaps = 16/160 (10%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +WE+  + +   ++LG+G+FG V++G   +I+    +    A+KT    +  +E+I E +
Sbjct: 1074 EWEVTRDSIHFIRELGQGSFGMVYEGIAKEIVKGKPE-TRCAIKTVNEHATDRERI-EFL 1131

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH------------- 219
             EA +M+  D  +VV+  GV +  +P  V+MEL + G L + L  +              
Sbjct: 1132 NEASVMKAFDTFHVVRLLGVVSRGQPTLVVMELMERGDLKTYLRSMRPDAEGSLPSSPPV 1191

Query: 220  -FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
               +    ++  + A+G+AY+  K  +HRD+AARNC+  G
Sbjct: 1192 PPTLQNILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAG 1231


>UniRef50_UPI0000ECD739 Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow
           tyrosine kinase gene in chromosome X protein)
           (Epithelial and endothelial tyrosine kinase) (ETK)
           (NTK38). n=2 Tax=Gallus gallus RepID=UPI0000ECD739
          Length = 633

 Score = 84.0 bits (206), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 67/215 (31%), Positives = 106/215 (49%), Gaps = 26/215 (12%)

Query: 54  KKTSANHFVVRESDHKVY--VDKIGFPTIIELVNHYVST--------KESFSTKDGTVKA 103
           KK +  H+ V ++    Y   +   F TI +L+N++           +   ST+   V A
Sbjct: 297 KKGTVKHYHVHKTPENKYYLTENHCFETIPKLINYHQHNSAGMVPRLRHVVSTQINKVPA 356

Query: 104 VLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESM 163
               ++    WEL  E++   ++LG G FG V  GK   + D       VAVK  K E +
Sbjct: 357 T--ASLGNGIWELKREEIVPLRELGSGQFGAVHLGKWKGLYD-------VAVKMIK-EGV 406

Query: 164 TKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHF 220
             E   E + EA+ M  L+H  +V+ +GV +   P+Y++ME    G+L S L   GK   
Sbjct: 407 VSED--EFVEEAQTMMKLNHPKLVRLYGVCSKLYPIYLVMEYMPNGSLLSYLQIHGKELQ 464

Query: 221 PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
           P+ +  E+ Y   + +A++    L+HRD+AARNCL
Sbjct: 465 PL-QLLEICYDVCDAMAFLESCQLIHRDLAARNCL 498


>UniRef50_B7Q0S4 Tyrosine-protein kinase receptor n=1 Tax=Ixodes scapularis
           RepID=B7Q0S4_IXOSC
          Length = 829

 Score = 84.0 bits (206), Expect = 5e-15,   Method: Composition-based stats.
 Identities = 54/162 (33%), Positives = 80/162 (49%), Gaps = 21/162 (12%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+    V   ++LGEGAFG+V++G+LL +      P+ VA+KT K  +  K Q ++  RE
Sbjct: 474 EVPSPQVRFLQELGEGAFGKVYRGELLPVKRDCSLPIQVAIKTLKENAAMKTQ-QDFQRE 532

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAAN 234
           A LM +L H N+V   GV    EPL ++ E    G L   L + H P  +    +   A+
Sbjct: 533 AELMSDLQHPNIVCLLGVCTKEEPLCMLFEYMPHGDLHEFLVQ-HSPRCEGTTQVLDLAD 591

Query: 235 -------------------GLAYIHEKNLMHRDVAARNCLYG 257
                              G+ Y+   + +HRD+AARNCL G
Sbjct: 592 FLHISRQASQSINAFFVAAGMEYLSAHHYVHRDLAARNCLVG 633


>UniRef50_B4JPQ9 GH13351 n=3 Tax=Drosophila RepID=B4JPQ9_DROGR
          Length = 1165

 Score = 84.0 bits (206), Expect = 5e-15,   Method: Composition-based stats.
 Identities = 53/157 (33%), Positives = 80/157 (50%), Gaps = 20/157 (12%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           KWE+  E+V + ++LGEGAFG V+ G+     D       VAVKT K    T++++ + +
Sbjct: 773 KWEVPRENVVVNRRLGEGAFGTVYGGEAKFNSD---DWTAVAVKTLKSGGSTEDRL-DFL 828

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--------------GKL 218
            EA  M+  +H N++K  GV    EP+Y IM+    G L + L                +
Sbjct: 829 AEAEAMKKFNHKNIIKLLGVCLQKEPIYTIMQFMLYGDLKTYLLARRNMVNEKITDESDI 888

Query: 219 HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
               +  Y +    A GLAY+ E+  +HRD+A RNCL
Sbjct: 889 SSKRLTMYAM--DVARGLAYLAEQKYVHRDIACRNCL 923


>UniRef50_A8XT57 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8XT57_CAEBR
          Length = 579

 Score = 84.0 bits (206), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 76/294 (25%), Positives = 128/294 (43%), Gaps = 51/294 (17%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           L H  +YHG++    ++++L     +L+R +      K+   +SV  + K         E
Sbjct: 66  LKHHLWYHGMMFGGTVEKLLKWEHSYLVRRAIQRSSMKKTLCISVKIDGKVLNFQLTWNE 125

Query: 66  SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTK 125
                      FP + +    Y    +       +V A+    V R +  L+H  + L  
Sbjct: 126 DGWGSTKLVAKFPKMAQ--KRYAHIYQLLDAWSLSVNAI--TPVPRNRIVLHHSSITLGN 181

Query: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
           KLG GAFGEV++ K L   +   + + VAVK A +    +  I+E   EA++M  L H+N
Sbjct: 182 KLGSGAFGEVYRAKYLP--NGASESIEVAVKRA-IGDAQRSTIQEFCHEAQVMGVLQHVN 238

Query: 186 VVKFFGVAAGTEPLYVIMELADGGAL-------------------DSALGKLHF-----P 221
           +V  +G+A+  +P+ ++MEL  GG L                   + A    HF     P
Sbjct: 239 IVCLYGIASLEQPVMLVMELVTGGDLRLCREMLLNTFRDAHALNFEGAEINTHFRYMNNP 298

Query: 222 M-----------------IKKYELIYQAAN---GLAYIHEKNLMHRDVAARNCL 255
           +                 I   +LI  AA+   G+ ++ ++ ++HRD+AARNCL
Sbjct: 299 IRFPNSLKFQKHLQTTHNISHRQLITFAADIASGMKHMAQRRVIHRDLAARNCL 352


>UniRef50_Q29D86 GA13409 n=5 Tax=Drosophila RepID=Q29D86_DROPS
          Length = 1071

 Score = 84.0 bits (206), Expect = 5e-15,   Method: Composition-based stats.
 Identities = 60/175 (34%), Positives = 92/175 (52%), Gaps = 13/175 (7%)

Query: 89  STKESFSTKDGTVKAVLKQAVERQKWELYHE-DVELTKKLGEGAFGEVWKGKLLKILDAN 147
           S K++ +T+D T      Q    Q   L HE D+ +  KLG+G+FG V +G+        
Sbjct: 95  SKKQASATRDST------QGNGTQLTCLIHEKDITMGLKLGDGSFGVVRRGEWSASPAGK 148

Query: 148 HQPVLVAVKTAKLESMTKEQI-KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELA 206
             PV  AVK  K +++T+  I  +  RE + M  LDH N+V+ +GV   ++P+ +I ELA
Sbjct: 149 VIPV--AVKVLKSDNLTQPGIIDDFFREVQAMHALDHSNLVRLYGVVL-SQPMMMITELA 205

Query: 207 DGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
           + G+L   L K   H  +   +    Q   G+AY+ +K  +HRD+A RN L   G
Sbjct: 206 ERGSLLDTLRKQCRHTALTHIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAG 260


>UniRef50_Q24488 Tyrosine-protein kinase transmembrane receptor Ror n=7
           Tax=Drosophila RepID=ROR1_DROME
          Length = 685

 Score = 83.6 bits (205), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 51/150 (34%), Positives = 80/150 (53%), Gaps = 10/150 (6%)

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           +DVE  ++LGEGAFG+V+KG+LL+    N   + VA+K  K  +  K Q ++  RE  L+
Sbjct: 408 QDVEFLEELGEGAFGKVYKGQLLQ---PNKTTITVAIKALKENASVKTQ-QDFKREIELI 463

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGAL------DSALGKLHFPMIKKYELIYQA 232
            +L H N+V   GV    EP  ++ E    G L      +S         ++  ++  Q 
Sbjct: 464 SDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQI 523

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + G+ Y+   + +HRD+AARNCL   G V+
Sbjct: 524 SEGMQYLSAHHYVHRDLAARNCLVNEGLVV 553


>UniRef50_Q05688 Insulin-like growth factor 1 receptor beta chain (Fragment) n=41
           Tax=Euteleostomi RepID=IGF1R_BOVIN
          Length = 640

 Score = 83.6 bits (205), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 50/154 (32%), Positives = 86/154 (55%), Gaps = 13/154 (8%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WE+  E + ++++LG+G+FG V++G + K +  +     VA+KT    +  +E+I E +
Sbjct: 264 EWEVAREKITMSRELGQGSFGMVYEG-VAKGVVKDEPETRVAIKTVNEAASMRERI-EFL 321

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPM---------- 222
            EA +M+  +  +VV+  GV +  +P  VIMEL   G L S L  L   M          
Sbjct: 322 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS 381

Query: 223 -IKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
             K  ++  + A+G+AY++    +HRD+AARNC+
Sbjct: 382 LSKMIQMAGEIADGMAYLNANKFVHRDLAARNCM 415


>UniRef50_UPI000186E0DC Insulin receptor precursor, putative n=2 Tax=Pediculus humanus
            corporis RepID=UPI000186E0DC
          Length = 1289

 Score = 83.6 bits (205), Expect = 7e-15,   Method: Compositional matrix adjust.
 Identities = 50/154 (32%), Positives = 87/154 (56%), Gaps = 13/154 (8%)

Query: 113  KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +WE+  E++EL ++LG+G+FG V++G    I+    + V  AVKT    S  ++++ E +
Sbjct: 929  EWEVPRENIELIRELGQGSFGMVYEGIARDIVQGEPE-VRCAVKTVNEVSTDRDRM-EFL 986

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL----------GKLHFPM 222
             EA +M+  +  +VV+  GV +  +P  V+MEL   G L + L           K   P 
Sbjct: 987  NEASVMKAFNTHHVVQLLGVVSEGQPTLVVMELMVNGDLKTYLRSHRPEFCEDKKKQPPT 1046

Query: 223  IKKY-ELIYQAANGLAYIHEKNLMHRDVAARNCL 255
            +++   +  + A+G+AY+  K  +HRD+AARNC+
Sbjct: 1047 LRRIIRMAMEIADGMAYLAAKKFVHRDLAARNCM 1080


>UniRef50_B6HTA0 Pc22g17780 protein n=1 Tax=Penicillium chrysogenum Wisconsin
           54-1255 RepID=B6HTA0_PENCW
          Length = 1342

 Score = 83.6 bits (205), Expect = 7e-15,   Method: Composition-based stats.
 Identities = 55/170 (32%), Positives = 88/170 (51%), Gaps = 18/170 (10%)

Query: 89  STKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANH 148
           + +E    +D  +K+  K   E +       D +L   LG+GAFG V++      L+ N 
Sbjct: 39  TKREEKPKEDKVLKSSAKDVAELK-------DYQLGDCLGKGAFGSVYRA-----LNWNT 86

Query: 149 QPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADG 208
               VAVK  KL  + K +++ IM E  L++NLDH N+VK+ G     E L +I+E  + 
Sbjct: 87  GET-VAVKQIKLTDLPKSELRVIMLEIDLLKNLDHPNIVKYHGFVKSAETLNIILEYCEN 145

Query: 209 GALDSA---LGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
           G+L S     G+    ++  Y  + Q  +GL Y+HE+ ++HRD+   N L
Sbjct: 146 GSLHSIAKNFGRFPENLVGLY--MSQVLHGLLYLHEQGVIHRDIKGANIL 193


>UniRef50_UPI0000D57178 PREDICTED: similar to Ret oncogene CG14396-PA n=1 Tax=Tribolium
           castaneum RepID=UPI0000D57178
          Length = 1065

 Score = 83.2 bits (204), Expect = 8e-15,   Method: Composition-based stats.
 Identities = 61/198 (30%), Positives = 98/198 (49%), Gaps = 35/198 (17%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVL-- 152
           S  D  +  ++ +     KWE     + + + LGEG FG+V + K L I   + QP L  
Sbjct: 717 SLADTAILNIINKYAPDPKWEFPRNRLIIEQTLGEGEFGKVLRAKALNI---SGQPGLTT 773

Query: 153 VAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGV-AAGTEPLYVIMELADGGAL 211
           VAVKT K +   + ++ +++ E +L++ + H NV++  GV  A   P+Y+I+E A+ G+L
Sbjct: 774 VAVKTLK-DDARESELNDLLSEYQLLKEVSHPNVIRLLGVCTAPGGPIYLIIEFAEHGSL 832

Query: 212 DSAL----------GKL----------HF--PMIKK------YELIYQAANGLAYIHEKN 243
            + L          G+L          H+  P I K          +Q   G+AY+ E  
Sbjct: 833 RNYLRRSRHLKSECGRLPSSTVDENDVHYDEPNISKVTPKEILSFAWQICKGMAYLSEIK 892

Query: 244 LMHRDVAARNCLYGGGQV 261
           L+HRD+AARN L    Q+
Sbjct: 893 LVHRDLAARNVLLAADQI 910


>UniRef50_UPI000194C599 PREDICTED: similar to leukocyte tyrosine kinase protein n=1
            Tax=Taeniopygia guttata RepID=UPI000194C599
          Length = 1390

 Score = 83.2 bits (204), Expect = 8e-15,   Method: Composition-based stats.
 Identities = 53/167 (31%), Positives = 90/167 (53%), Gaps = 13/167 (7%)

Query: 106  KQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTK 165
            K A   +  E+  +++ L + LG GAFGEV++G ++ I   +  P+ VA+KT   E  ++
Sbjct: 846  KAATLSELKEIPRKNISLLRALGHGAFGEVYEGTVVGIA-GDPNPLQVAIKTLP-EVCSE 903

Query: 166  EQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK 225
            +   + + EA ++   +H N+V+  GV+  T P ++++EL  GG + S L +    M + 
Sbjct: 904  QDEMDFLMEALIISKFNHQNIVQCIGVSLQTLPRFILLELMAGGDMKSFLRQNRPRMNQP 963

Query: 226  YELIYQ--------AANGLAYIHEKNLMHRDVAARNCLY---GGGQV 261
              L  Q         A G  Y+ E + +HRD+AARNCL    G G++
Sbjct: 964  STLTMQDLLNIARDIACGCKYLEENHFIHRDIAARNCLLTCTGAGRI 1010


>UniRef50_UPI000186EF8B ALK tyrosine kinase receptor precursor, putative n=1 Tax=Pediculus
           humanus corporis RepID=UPI000186EF8B
          Length = 1259

 Score = 83.2 bits (204), Expect = 9e-15,   Method: Composition-based stats.
 Identities = 53/149 (35%), Positives = 79/149 (53%), Gaps = 10/149 (6%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+  E++ L K LG+GAFGEV++G   +    +   + VAVKT   E  T +   + + E
Sbjct: 800 EVPRENLRLVKALGQGAFGEVYQG-FYRYRTGDIIEMPVAVKTLP-ELSTSQAETDFLME 857

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH------FPMIKKYEL 228
           A +M    H N+V F GV     P ++++EL  GG L + L +         P++ K  L
Sbjct: 858 ALIMSKFTHPNIVHFIGVCFDKHPRFIVLELLAGGDLKNFLRESRPKPERPSPLVMKDLL 917

Query: 229 I--YQAANGLAYIHEKNLMHRDVAARNCL 255
           +     A G AY+ E   +HRD+AARNCL
Sbjct: 918 MCAIDVAKGCAYLEEHRFIHRDIAARNCL 946


>UniRef50_Q9Y1X8 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X8_9METZ
          Length = 1193

 Score = 83.2 bits (204), Expect = 9e-15,   Method: Composition-based stats.
 Identities = 53/138 (38%), Positives = 79/138 (57%), Gaps = 7/138 (5%)

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           +E  + LG GAFG V+KG      D N   V  A+K  K E+ T +   E++RE  +M  
Sbjct: 841 LEQGQVLGSGAFGTVYKGHWRPEGDPNCYEV--AIKVLKEETATPQSQTELLREGAVMAT 898

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELI---YQAANGLA 237
           +DHINVV+ + V  G + + +I E    G+L S L K +   +  Y ++    Q A+G+A
Sbjct: 899 MDHINVVRLYCVCMGKQ-MMLITEFVRLGSLLSYL-KNNQATLDAYSMLNFSRQIADGMA 956

Query: 238 YIHEKNLMHRDVAARNCL 255
           Y+ EK ++HRD+AARN L
Sbjct: 957 YLEEKRMVHRDLAARNVL 974


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score = 82.8 bits (203), Expect = 9e-15,   Method: Compositional matrix adjust.
 Identities = 75/263 (28%), Positives = 135/263 (51%), Gaps = 39/263 (14%)

Query: 11  YYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDH 68
           ++HG + R++ + +L   + G FL+R S    G+   + L V  + K    H+ V+  ++
Sbjct: 479 WFHGSITRDEAEHLLQPREDGLFLVRESTNFPGD---YTLCVCFQSKV--EHYRVKYLEN 533

Query: 69  KVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER----------QKWELY 117
           K+ +D +  F  + +LV HY +  +   T+   +K + K   +           + W + 
Sbjct: 534 KLTIDDEEYFENLGQLVAHYEADADGLCTQ--LIKCLPKLGKQEFCINSKDFVDKGWVIP 591

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
             +++L + +G+G FG+V    +L IL        VAVK  K E      +++ + EA +
Sbjct: 592 EAELQLRESIGKGEFGDV----MLGILRNEK----VAVKMLKDEGA----VQKFLAEASV 639

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKYELI--YQA 232
           M  L+H N+VKF G+   ++ LY++ E    G+L   L   G+ H  + KK ++I  Y  
Sbjct: 640 MTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQH--ITKKDQIIFAYDT 697

Query: 233 ANGLAYIHEKNLMHRDVAARNCL 255
           A+G+ Y+  K ++HRD+AARN L
Sbjct: 698 ASGMEYLEAKKVVHRDLAARNVL 720


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score = 82.8 bits (203), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 68/264 (25%), Positives = 127/264 (48%), Gaps = 31/264 (11%)

Query: 6   LLHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L+   ++HG + RE  + +L   + G FL+R S    G+   + L V  + +   +H+ +
Sbjct: 96  LIPMPWFHGKISRELAESLLMPREDGLFLVRESAHFPGD---YTLCVCFQDQV--DHYRM 150

Query: 64  RESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA-----VERQK---W 114
           +  + K+ +D+ + F ++ ELV HY    +   T+    K V+KQ      ++ +K   W
Sbjct: 151 QGKNGKLTIDEEVYFSSLEELVQHYEKDADGLCTR--LRKPVVKQGGREFKIDARKFVNW 208

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+   ++  + ++G G FG+V++G         ++   VA+KT  L+ +  + I + + E
Sbjct: 209 EISPREIVKSAQIGSGQFGDVFEGL--------YRGQKVAIKT--LKDVQGDAIDQFLLE 258

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKYELIYQ 231
           A  M  L H N+V+  GV     P+ ++ E    G L   L   G+    +  +      
Sbjct: 259 ADTMTRLRHKNLVQLIGVCTQGSPIMIVSEFMGKGCLLDYLRSRGRAVINLATQLGFCRD 318

Query: 232 AANGLAYIHEKNLMHRDVAARNCL 255
               + Y+ E+  +HRD+AARN L
Sbjct: 319 ICAAMEYLEEQKFVHRDLAARNIL 342


>UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n=1 Tax=Ciona intestinalis
           RepID=UPI000180C4D7
          Length = 525

 Score = 82.8 bits (203), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 55/153 (35%), Positives = 80/153 (52%), Gaps = 19/153 (12%)

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+  E +   KKLG GAFGEVWKG         HQ   VA+K  +  +M+ E     ++
Sbjct: 254 WEIGREHLTQQKKLGAGAFGEVWKGGF-------HQD--VAIKELQPCTMSPE---AFLQ 301

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL----GKLHFPMIKKYELI 229
           EA +MR L H N+V  + V   TEP+ ++ E    G+L   L    G   FP +   ++ 
Sbjct: 302 EAEIMRKLRHPNIVSIYAVI--TEPINIVTEFMCHGSLLDYLKDGPGSF-FPFVDLIDMA 358

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            Q A G+A+I ++  +HRD+ A N L G  +V 
Sbjct: 359 AQIAAGMAFIEQEKYIHRDLRADNVLVGENRVC 391


>UniRef50_Q03351 NT-3 growth factor receptor n=21 Tax=Euteleostomi RepID=NTRK3_RAT
          Length = 864

 Score = 82.8 bits (203), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 51/157 (32%), Positives = 80/157 (50%), Gaps = 22/157 (14%)

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           D+ L ++LGEGAFG+V+  +    L      +LVAVK  K  ++     K+  REA L+ 
Sbjct: 537 DIVLKRELGEGAFGKVFLAECYN-LSPTKDKMLVAVKALKDPTLAAR--KDFQREAELLT 593

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP------------------ 221
           NL H ++VKF+GV    +PL ++ E    G L+  L + H P                  
Sbjct: 594 NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL-RAHGPDAMILVDGQPRQAKGELG 652

Query: 222 MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           + +   +  Q A+G+ Y+  ++ +HRD+A RNCL G 
Sbjct: 653 LSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA 689


>UniRef50_Q16288 NT-3 growth factor receptor n=57 Tax=Euteleostomi RepID=NTRK3_HUMAN
          Length = 839

 Score = 82.8 bits (203), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 51/157 (32%), Positives = 80/157 (50%), Gaps = 22/157 (14%)

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           D+ L ++LGEGAFG+V+  +    L      +LVAVK  K  ++     K+  REA L+ 
Sbjct: 537 DIVLKRELGEGAFGKVFLAECYN-LSPTKDKMLVAVKALKDPTLAAR--KDFQREAELLT 593

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP------------------ 221
           NL H ++VKF+GV    +PL ++ E    G L+  L + H P                  
Sbjct: 594 NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL-RAHGPDAMILVDGQPRQAKGELG 652

Query: 222 MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           + +   +  Q A+G+ Y+  ++ +HRD+A RNCL G 
Sbjct: 653 LSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA 689


>UniRef50_Q98TD0 Ephrin receptor n=6 Tax=Amniota RepID=Q98TD0_CHICK
          Length = 969

 Score = 82.4 bits (202), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 47/137 (34%), Positives = 75/137 (54%), Gaps = 6/137 (4%)

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V +   +GEG FGEV++G L        + ++VA+KT K  + +  Q    +REA +M  
Sbjct: 616 VTMENVIGEGEFGEVYRGSLRL---PGKERIVVAIKTLK-STYSDSQWWNFLREATIMGQ 671

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAY 238
            +H N+V   GV     P+ +I E  + GALD+ L   +  F  ++   ++   A+G+ Y
Sbjct: 672 FNHPNIVHLEGVVTKRRPMMIITEYMENGALDTFLRENEEKFSPVQLVNMLQGIASGMTY 731

Query: 239 IHEKNLMHRDVAARNCL 255
           + E N +HRD+AARN L
Sbjct: 732 LSEHNYVHRDLAARNIL 748


>UniRef50_C4V8N0 Putative uncharacterized protein n=1 Tax=Nosema ceranae BRL01
           RepID=C4V8N0_NOSCE
          Length = 271

 Score = 82.4 bits (202), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 51/147 (34%), Positives = 77/147 (52%), Gaps = 9/147 (6%)

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLES-MTKEQIKEIMREARL 177
           +D EL K LG G FGEVW  K        ++  +VA+K  K  S +TKE  K+I RE  +
Sbjct: 10  DDFELGKPLGRGKFGEVWMAK------EKNKDFIVALKIIKRASILTKETAKQIRREIDI 63

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY--QAANG 235
            R L H N+++ +G    +E LY+I+E A  G     L + +    +K   +Y  Q  + 
Sbjct: 64  HRRLKHDNILRMYGYFYDSERLYLILEFAGKGEFFKILNENNGKFSEKTTSVYIKQLIDA 123

Query: 236 LAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L Y+H+ +++HRD+   N L G    L
Sbjct: 124 LIYMHKNDVIHRDIKPENLLLGSDDRL 150


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score = 82.0 bits (201), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 72/268 (26%), Positives = 131/268 (48%), Gaps = 32/268 (11%)

Query: 9   QKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           + ++ G + R +   ML    + G FL+R SE   GE   + LS+         H+ ++ 
Sbjct: 343 EPWFRGRISRAEAAAMLQITKQEGCFLVRESETQPGE---YTLSL--SHNEGVRHYRIQH 397

Query: 66  SDHKVYVDKI-GFPTIIELVNHY------VSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
            + + +V++   F +I +L+ ++      + T+   +  D    A +   +    WEL  
Sbjct: 398 IEGQYFVNENHRFDSIPQLIEYHKLNGGGIVTRLRRAIND--ANAPISVGLGHDMWELSR 455

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           ++ EL ++LG G FG V + +       N Q   VA+K  K   M+ +   + + EA +M
Sbjct: 456 DEFELGRELGSGQFGIVQQARY-----RNGQ--AVAIKMMKEGKMSAD---DFISEAVVM 505

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY----QAAN 234
           R+L H ++V+  GV     PL++I EL   G L + L + H  +  + ++++      A+
Sbjct: 506 RDLSHPHLVQLLGVCTKGGPLWIITELMSKGCLLNYL-RDHKELRGEPQILHMMCVHIAS 564

Query: 235 GLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + Y+  K  +HRD+AARNCL G   V+
Sbjct: 565 AMEYLESKGFIHRDLAARNCLLGDNYVV 592


>UniRef50_A3KPS2 Tyrosine-protein kinase receptor (Fragment) n=11 Tax=Clupeocephala
           RepID=A3KPS2_DANRE
          Length = 853

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 51/155 (32%), Positives = 81/155 (52%), Gaps = 21/155 (13%)

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           ++ L ++LGEGAFG+V+  +    L  + + +LVAVKT K  S +     +  REA L+ 
Sbjct: 566 NILLKRELGEGAFGKVFLAECYN-LSPDQEKILVAVKTLKEASESGR--ADFHREAELLT 622

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP-----------------M 222
           NL H ++VKF+GV   ++PL ++ E    G L+  L + H P                  
Sbjct: 623 NLQHEHIVKFYGVCVESDPLIMVFEYMKHGDLNKFL-RAHGPDAVLMADGQQSLLVELTQ 681

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
            +   +  Q A G+ Y+  ++ +HRD+A RNCL G
Sbjct: 682 PQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG 716


>UniRef50_Q4SUM3 Ephrin receptor (Fragment) n=5 Tax=Tetraodontidae
           RepID=Q4SUM3_TETNG
          Length = 1173

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 47/137 (34%), Positives = 78/137 (56%), Gaps = 6/137 (4%)

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V++ + +G G FGEV  G L +      + +LVA+KT K+   T+ Q ++ + EA +M  
Sbjct: 661 VKIEQVIGAGEFGEVCSGNLRQ---PGKREILVAIKTLKV-GYTERQRRDFLSEASIMGQ 716

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAY 238
            DH N++   GV   + P+ +I E  + G+LDS L +    F +I+   ++   A G+ Y
Sbjct: 717 FDHPNIIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGVKY 776

Query: 239 IHEKNLMHRDVAARNCL 255
           + + N +HRD+AARN L
Sbjct: 777 LCDMNYVHRDLAARNIL 793


>UniRef50_UPI000194BE92 PREDICTED: similar to fusion protein EML4-ALK n=1 Tax=Taeniopygia
            guttata RepID=UPI000194BE92
          Length = 1378

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 50/150 (33%), Positives = 83/150 (55%), Gaps = 12/150 (8%)

Query: 115  ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK-EIMR 173
            E+  +++ L + LG GAFGEV++G++  I  ++  P+ VAVKT  L  +  EQ + + + 
Sbjct: 866  EVPRKNISLIRGLGHGAFGEVYEGQVTGI-PSDPTPLQVAVKT--LPEVCSEQDELDFLM 922

Query: 174  EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIKK 225
            EA ++   +H N+V+  GV+    P ++++EL  GG L S L +            M+  
Sbjct: 923  EALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPSSLSMLDL 982

Query: 226  YELIYQAANGLAYIHEKNLMHRDVAARNCL 255
              +    A G  Y+ E + +HRD+AARNCL
Sbjct: 983  LHVARDIACGCQYLEENHFIHRDIAARNCL 1012


>UniRef50_A9UQ73 Predicted protein (Fragment) n=1 Tax=Monosiga brevicollis
           RepID=A9UQ73_MONBE
          Length = 278

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 52/158 (32%), Positives = 79/158 (50%), Gaps = 9/158 (5%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVK------TAKLESMTKE 166
           +WE   + +     LGEG FG V + + L I D   + V VAVK      +   +S++ E
Sbjct: 5   QWEYDRQQLFFKGHLGEGQFGTVSRARALDIRDQVGE-VDVAVKQCGSRKSGTTDSISVE 63

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK- 225
            +   ++EA +M+  DH NV++  GV    EPLYVI EL + G L S L      +  + 
Sbjct: 64  NMYRFVKEANVMKRFDHRNVLRLLGVCLQEEPLYVITELMEKGDLLSYLRTAAKSLTTRQ 123

Query: 226 -YELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              +    A G++Y+H    +H D+A RNCL     V+
Sbjct: 124 LTAMSSDVAEGMSYLHSLQFVHGDLACRNCLVNANGVV 161


>UniRef50_A8NGE1 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NGE1_BRUMA
          Length = 1009

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 54/144 (37%), Positives = 78/144 (54%), Gaps = 17/144 (11%)

Query: 119 EDVELTKKLGEGAFG----EVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+++L ++LGEG+F      VW  K  + LD       VA K   L   T E I+++ RE
Sbjct: 119 EEIKLMERLGEGSFAVVKRAVWTPKTGRKLD-------VAAKI--LRDSTPEIIEDLQRE 169

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELI---YQ 231
              M+ L H N+++ +G+   + P  +I+E  DGGAL   L     P+I    LI    Q
Sbjct: 170 VTNMQKLKHPNLIQLYGIVF-SNPAMMIVEFCDGGALIDRLRSTEKPVILVSMLIDYAQQ 228

Query: 232 AANGLAYIHEKNLMHRDVAARNCL 255
            A G+AY+  KN +HRD+AARN L
Sbjct: 229 IAQGMAYLESKNCVHRDLAARNVL 252


>UniRef50_Q12866 Tyrosine-protein kinase Mer n=37 Tax=root RepID=MERTK_HUMAN
          Length = 999

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 60/193 (31%), Positives = 97/193 (50%), Gaps = 25/193 (12%)

Query: 82  ELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE-------LTKKLGEGAFGE 134
           ELV +Y++ K+SF  +   ++  L      ++ +   EDV        L K LGEG FG 
Sbjct: 544 ELVVNYIA-KKSFCRR--AIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS 600

Query: 135 VWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGV-- 192
           V +G L +    +   + VAVKT KL++ ++ +I+E + EA  M++  H NV++  GV  
Sbjct: 601 VMEGNLKQ---EDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCI 657

Query: 193 ---AAGTEPLYVIMELADGGALDSAL-------GKLHFPMIKKYELIYQAANGLAYIHEK 242
              + G     VI+     G L + L       G  H P+    + +   A G+ Y+  +
Sbjct: 658 EMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNR 717

Query: 243 NLMHRDVAARNCL 255
           N +HRD+AARNC+
Sbjct: 718 NFLHRDLAARNCM 730


>UniRef50_C4QEV8 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4QEV8_SCHMA
          Length = 643

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 53/157 (33%), Positives = 86/157 (54%), Gaps = 14/157 (8%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKG---KLLKILDANHQPVLVAVKTAKLESMTKEQI 168
           + +E   ++++LT +LG GAFG V++G    L   ++ N + + VAVKT K +  T+  +
Sbjct: 344 EDYEFSRKNLQLTCRLGSGAFGIVYRGVAENLPNCINTNEK-IDVAVKTLK-DDFTEGDV 401

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPM------ 222
            E + E  +M+ L H ++++F+GV        +IME A  G L   L + H  +      
Sbjct: 402 SEFLMEVNIMKQLRHKHIIEFYGVCTENGSPLLIMEYAPYGNLKEYLRR-HRKIWLNCDN 460

Query: 223 --IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
             +K     YQ A+G+ Y+  K L+HRD+AARN L G
Sbjct: 461 LSLKLLNFGYQVADGMKYLESKCLIHRDLAARNILVG 497


>UniRef50_C4Q2H0 Tyrosine kinase n=2 Tax=Schistosoma mansoni RepID=C4Q2H0_SCHMA
          Length = 1560

 Score = 81.6 bits (200), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 55/151 (36%), Positives = 81/151 (53%), Gaps = 18/151 (11%)

Query: 120  DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
            D+ L +++G+GAFG V+ G+  +    N +   VAVK       T E   + + EA+LMR
Sbjct: 995  DIVLNRRVGQGAFGMVYGGEAKR----NGRWEAVAVKVIG-NKATYEGKTDFLSEAKLMR 1049

Query: 180  NLDHINVVKFFGVA--AGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQA--- 232
            +LDH NVV+  G+        LY+IME    G L + L   ++    +  ++ +  A   
Sbjct: 1050 SLDHRNVVRLVGICLYPKENHLYLIMEFMLNGDLKTYLLSRRVLAQQVPDHDGVCPATLT 1109

Query: 233  ------ANGLAYIHEKNLMHRDVAARNCLYG 257
                  A GLAY+H KNL+HRD+A RNCL G
Sbjct: 1110 GMAIDIAEGLAYLHRKNLIHRDIACRNCLVG 1140


>UniRef50_Q7PYY7 AGAP011648-PA (Fragment) n=2 Tax=Culicidae RepID=Q7PYY7_ANOGA
          Length = 706

 Score = 81.6 bits (200), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 49/163 (30%), Positives = 92/163 (56%), Gaps = 17/163 (10%)

Query: 108 AVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
           ++ + +WE     +++   LGEGAFG+VW+ +   I D +    + AVKT K E+ ++ +
Sbjct: 390 SIVKDRWEFPRHRLKVFNILGEGAFGQVWRCEATDI-DGHEGVSVTAVKTLK-ENASEAE 447

Query: 168 IKEIMREARLMRNLD-HINVVKFFGVAAGTEPLYVIMELADGGALDSAL---------GK 217
             +++ E +++++L+ HINVV+  G     +P++VI+E  + G L + L         G 
Sbjct: 448 RNDLLSELQVLKSLEPHINVVRLLGCCTEKDPIFVILEYVNMGKLQTFLRNSRVEKHYGN 507

Query: 218 LH--FPMIKKYEL---IYQAANGLAYIHEKNLMHRDVAARNCL 255
            H    ++   +L   +YQ A G+ ++  + ++HRD+AARN L
Sbjct: 508 THGKSKILTSGDLTSFMYQVARGMDFLTSRGIIHRDLAARNIL 550


>UniRef50_B4LZ52 GJ23294 n=4 Tax=Coelomata RepID=B4LZ52_DROVI
          Length = 1966

 Score = 81.3 bits (199), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 53/152 (34%), Positives = 83/152 (54%), Gaps = 16/152 (10%)

Query: 114  WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANH--QPVLVAVKTAKLESMTKEQIKEI 171
            WE+  E +     LG+G+FG V++G    IL A +  + +  A+KT   E+ T  +    
Sbjct: 1150 WEVPRERIIQLGPLGQGSFGMVYEG----ILKAQNTGEDIPCAIKTVN-ENATDRERTNF 1204

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK----YE 227
            + EA +M+  D  +VV+  GV +  +P  V+MEL   G L S L + H P  ++    Y 
Sbjct: 1205 LSEASVMKEFDTYHVVRLLGVCSCGQPALVVMELMKKGDLKSYL-RAHRPDEREDPPPYS 1263

Query: 228  LIYQAA----NGLAYIHEKNLMHRDVAARNCL 255
             I+Q A    +G+AY+  K  +HRD+AARNC+
Sbjct: 1264 RIFQMAIEIADGMAYLAAKKFVHRDLAARNCM 1295


>UniRef50_A2QHV0 Contig An04c0070, complete genome n=2 Tax=Aspergillus
           RepID=A2QHV0_ASPNC
          Length = 1336

 Score = 81.3 bits (199), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 56/168 (33%), Positives = 86/168 (51%), Gaps = 18/168 (10%)

Query: 91  KESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQP 150
           K+     D  VK+  K   E +       D +L   LG+GAFG V++      L+ N   
Sbjct: 36  KQDKPKDDRVVKSSAKDVAELK-------DYQLGDCLGKGAFGSVYRA-----LNWNTGE 83

Query: 151 VLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGA 210
             VAVK  KL  + K +++ IM E  L++NLDH N+VK+ G     E L +I+E  + G+
Sbjct: 84  T-VAVKQIKLVDLPKSELRVIMLEIDLLKNLDHPNIVKYQGFVKSAETLNIILEYCENGS 142

Query: 211 LDSA---LGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
           L S     G+    ++  Y  + Q  +GL Y+HE+ ++HRD+   N L
Sbjct: 143 LHSIAKNFGRFPENLVGLY--MSQVLHGLLYLHEQGVIHRDIKGANIL 188


>UniRef50_UPI000186EA5D proto-oncogene receptor tyrosine protein kinase ret, putative n=1
           Tax=Pediculus humanus corporis RepID=UPI000186EA5D
          Length = 870

 Score = 81.3 bits (199), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 56/188 (29%), Positives = 95/188 (50%), Gaps = 24/188 (12%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           S ++GT+K + +     +KWE     + + + LGEG FG+V K K   I   N     VA
Sbjct: 432 SVQNGTIKEISEHY--DKKWEFPRYRLTIEEILGEGEFGKVLKAKADGI-GGNPGSTTVA 488

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE-PLYVIMELADGGALDS 213
           VKT K +   + ++ ++M E +L++++DH NV+   G    ++ P+Y+I+E A  G+L +
Sbjct: 489 VKTLK-DDAKETELSDLMSEYQLLKDIDHPNVIHLLGACTKSDGPVYIIIEYAKHGSLRN 547

Query: 214 ALGKLHFPMIKKYE-------------------LIYQAANGLAYIHEKNLMHRDVAARNC 254
            L K    +I++                       +Q A G+ Y+ +  L+HRD+AARN 
Sbjct: 548 YLRKHRAAIIEQLNHNDNNMGVEKNVTPKDLLTFAWQIAKGMNYLTDMKLVHRDLAARNI 607

Query: 255 LYGGGQVL 262
           L   G + 
Sbjct: 608 LVAEGLIC 615


>UniRef50_Q7KJ08 Alk n=7 Tax=melanogaster group RepID=Q7KJ08_DROME
          Length = 1701

 Score = 81.3 bits (199), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 53/159 (33%), Positives = 89/159 (55%), Gaps = 13/159 (8%)

Query: 115  ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
            ++  + ++L   LG+GAFGEV+   L +  D +   + VAVKT + E   +E+ ++ ++E
Sbjct: 1187 QVARDSLQLVNALGKGAFGEVYMA-LYRHRDGDAVEMGVAVKTLR-EDPKREKEEDFLKE 1244

Query: 175  ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK-LHFP----MIKKYELI 229
            A +M   +H N+V   GV    +P Y+++EL  GG L   L +  + P    ++   +L+
Sbjct: 1245 AAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLL 1304

Query: 230  YQA---ANGLAYIHEKNLMHRDVAARNCLY---GGGQVL 262
            + A   A G  Y+  K  +HRD+AARNCL    G G+V+
Sbjct: 1305 FCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVV 1343


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score = 81.3 bits (199), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 68/247 (27%), Positives = 116/247 (46%), Gaps = 34/247 (13%)

Query: 23  EMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIGFP-TII 81
           + LN+P Q    +S P          ++   +    N F V    H+   +   FP T I
Sbjct: 335 QFLNQPMQQSCYSSVP---------QTLPSSRIPGPNQFEVNPIVHQSNAEISNFPLTHI 385

Query: 82  ELVNH--------YVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFG 133
             V+H        +++  E  S    ++ ++     E   WE+   ++ + +KLG G +G
Sbjct: 386 NPVSHVPRPFHPSHINNSERLSAYSDSIGSM-----EFDGWEIDRPEIIMRQKLGCGQYG 440

Query: 134 EVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVA 193
           +V++  + K  ++     +VAVKT K +      + + ++EA +M+ L + N+V+  GV 
Sbjct: 441 DVYEA-VWKRFNS-----VVAVKTLKQD--VNLNVNDFLKEAAIMKKLRNRNLVQLLGVC 492

Query: 194 AGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY---QAANGLAYIHEKNLMHRDVA 250
               PLY+I E    G L + L       +    L+Y   Q A+G+AY+   N +HRD+A
Sbjct: 493 TRELPLYLITEYMPNGNLLNYLRTRSPGELTPLTLLYMAVQIASGMAYLEANNFIHRDLA 552

Query: 251 ARNCLYG 257
           ARNCL G
Sbjct: 553 ARNCLVG 559


>UniRef50_Q8T2I8 Putative uncharacterized protein sepA n=1 Tax=Dictyostelium
           discoideum RepID=Q8T2I8_DICDI
          Length = 1167

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 45/130 (34%), Positives = 72/130 (55%), Gaps = 7/130 (5%)

Query: 127 LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINV 186
           +G+G FG V++G  L I D +     VA+K   L  + K+Q++ IM E  L++NL+H N+
Sbjct: 24  IGKGGFGTVYQG--LDIEDGD----FVAIKQINLTKIPKDQLQGIMNEIDLLKNLNHANI 77

Query: 187 VKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIHEKNLM 245
           VK+       + LY+++E  + G+L   + K   FP       I Q   GL Y+HE+ ++
Sbjct: 78  VKYIKYVKTKDNLYIVLEYVENGSLSGIIKKFGKFPETLVCVYIRQVLEGLVYLHEQGVV 137

Query: 246 HRDVAARNCL 255
           HRD+   N L
Sbjct: 138 HRDIKGANIL 147


>UniRef50_B2W0T3 Serine/threonine-protein kinase 3 n=5 Tax=Leotiomyceta
           RepID=B2W0T3_PYRTR
          Length = 1354

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 46/140 (32%), Positives = 77/140 (55%), Gaps = 11/140 (7%)

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           +D +L   LG+GAFG V++       +       VA+K  +LE++    +K +  E  L+
Sbjct: 48  KDYQLGDCLGKGAFGSVYRALNWGTGET------VAIKQVRLENLGAADLKNMEMEIDLL 101

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA---LGKLHFPMIKKYELIYQAANG 235
           +NL+H N+VK+ G    +E LY+I+E  + G+L S     GK    ++  Y  + Q  +G
Sbjct: 102 KNLNHANIVKYHGFVRSSESLYIILEYCENGSLHSICKNFGKFPENLVALY--MSQVLHG 159

Query: 236 LAYIHEKNLMHRDVAARNCL 255
           L Y+HE+ ++HRD+   N L
Sbjct: 160 LLYLHEQGVIHRDIKGANIL 179


>UniRef50_Q7PZ80 AGAP011776-PA n=4 Tax=Culicidae RepID=Q7PZ80_ANOGA
          Length = 1082

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 53/152 (34%), Positives = 83/152 (54%), Gaps = 16/152 (10%)

Query: 116 LYHE-DVELTKKLGEGAFGEVWKGKLLKILDANHQP----VLVAVKTAKLESMTKEQ-IK 169
           L HE DV L+ KLG+G+FG V +G+        H P    V VAVK  K +++ +   I+
Sbjct: 114 LIHEKDVTLSVKLGDGSFGVVRRGEW-------HAPGNHLVPVAVKVLKADTLAQPGVIE 166

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYE 227
           +  +E + M  ++H N+++  GV   ++P+ ++ ELA  G+L   L K   H P+   + 
Sbjct: 167 DFFKEVQAMHAMNHPNLIRLHGVVL-SQPMMMVTELAVNGSLLDLLRKQCKHTPLPMIWS 225

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
              Q A G+AY+  K  +HRD+A RN L   G
Sbjct: 226 WSVQIATGMAYLESKRFLHRDLACRNVLLAAG 257


>UniRef50_Q9VZI2 Ack n=9 Tax=Drosophila RepID=Q9VZI2_DROME
          Length = 1073

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 58/173 (33%), Positives = 88/173 (50%), Gaps = 7/173 (4%)

Query: 91  KESFSTKDGTVKAVLKQAVERQKWELYHE-DVELTKKLGEGAFGEVWKGKLLKILDANHQ 149
           K+  S K  +      Q    Q   L HE D+ +  KLG+G+FG V +G+          
Sbjct: 92  KQPSSKKQSSAARESSQGNGTQLTCLIHEKDITMGLKLGDGSFGVVRRGEWSASPAGKVI 151

Query: 150 PVLVAVKTAKLESMTKEQI-KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADG 208
           PV  AVK  K +++T+  I  +  RE + M  LDH N+V+ +GV   ++P+ +I ELA+ 
Sbjct: 152 PV--AVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVL-SQPMMMITELAER 208

Query: 209 GALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
           G+L   L K   H  +   +    Q   G+AY+ +K  +HRD+A RN L   G
Sbjct: 209 GSLLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAG 261


>UniRef50_Q28WN9 GA20930 n=6 Tax=Drosophila RepID=Q28WN9_DROPS
          Length = 1705

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 53/155 (34%), Positives = 87/155 (56%), Gaps = 13/155 (8%)

Query: 119  EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
            + ++L   LG+GAFGEV+   L +  D +   + VAVKT + E   +E+ ++ ++EA +M
Sbjct: 1195 DSLQLVNALGKGAFGEVYMA-LYRHRDGDAVEMGVAVKTLR-EDPKREKEEDFLKEAAIM 1252

Query: 179  RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK-LHFP----MIKKYELIYQA- 232
               +H N+V   GV    +P Y+++EL  GG L   L +  + P    ++   +L++ A 
Sbjct: 1253 AKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCAL 1312

Query: 233  --ANGLAYIHEKNLMHRDVAARNCLY---GGGQVL 262
              A G  Y+  K  +HRD+AARNCL    G G+V+
Sbjct: 1313 DVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVV 1347


>UniRef50_B4DSE0 Ephrin receptor n=19 Tax=Euteleostomi RepID=B4DSE0_HUMAN
          Length = 928

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 64/213 (30%), Positives = 107/213 (50%), Gaps = 15/213 (7%)

Query: 48  LSVVGEKKTSANHFVVRE---SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAV 104
           ++V G K  +   F VR    + +  Y  K+ F T+ E+        + F+ +D      
Sbjct: 493 VTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEVTPGMKIYIDPFTYEDPN---- 548

Query: 105 LKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMT 164
             +AV     E+    V++ + +G G FGEV  G L K+     + + VA+KT K    T
Sbjct: 549 --EAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHL-KL--PGKREIFVAIKTLK-SGYT 602

Query: 165 KEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPM 222
           ++Q ++ + EA +M   DH NV+   GV   + P+ +I E  + G+LDS L +    F +
Sbjct: 603 EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTV 662

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
           I+   ++   A G+ Y+ + N +HRD+AARN L
Sbjct: 663 IQLVGMLRGIAAGMKYLADMNYVHRDLAARNIL 695


>UniRef50_Q4SK07 Tyrosine-protein kinase receptor (Fragment) n=2 Tax=Tetraodontidae
           RepID=Q4SK07_TETNG
          Length = 1084

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 49/150 (32%), Positives = 78/150 (52%), Gaps = 12/150 (8%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK-EIMR 173
           E+   ++ LT+ LG GAFGEV++G  + I      P+ VAVKT  L  +  EQ + + + 
Sbjct: 493 EVSRRNISLTRGLGHGAFGEVYEGLAVGI-PGEPSPLQVAVKT--LPEVCSEQDELDFLM 549

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIKK 225
           EA ++    H N+V+  GV+    P ++++EL  GG L + + +            M+  
Sbjct: 550 EALIISKFSHQNIVRCVGVSLQAMPRFILLELMTGGDLKTFMRETRPRPEHPSSLTMVDL 609

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCL 255
             +    A G  Y+ E   +HRD+AARNCL
Sbjct: 610 LNIARDIAKGCQYLEENQFIHRDIAARNCL 639


>UniRef50_Q16620 BDNF/NT-3 growth factors receptor n=90 Tax=Euteleostomi
           RepID=NTRK2_HUMAN
          Length = 822

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 51/153 (33%), Positives = 83/153 (54%), Gaps = 19/153 (12%)

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           ++ L ++LGEGAFG+V+  +    L      +LVAVKT  L+  +    K+  REA L+ 
Sbjct: 537 NIVLKRELGEGAFGKVFLAECYN-LCPEQDKILVAVKT--LKDASDNARKDFHREAELLT 593

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP------------MIKKYE 227
           NL H ++VKF+GV    +PL ++ E    G L+  L + H P             + + +
Sbjct: 594 NLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFL-RAHGPDAVLMAEGNPPTELTQSQ 652

Query: 228 LIY---QAANGLAYIHEKNLMHRDVAARNCLYG 257
           +++   Q A G+ Y+  ++ +HRD+A RNCL G
Sbjct: 653 MLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG 685


>UniRef50_P09208 Insulin-like receptor subunit beta 2 n=48 Tax=Coelomata
            RepID=INSR_DROME
          Length = 2144

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 51/165 (30%), Positives = 81/165 (49%), Gaps = 25/165 (15%)

Query: 114  WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
            WE+  E++     LG+G+FG V++G +LK    N      A+KT   E+ T  +    + 
Sbjct: 1364 WEVLRENIIQLAPLGQGSFGMVYEG-ILKSFPPNGVDRECAIKTVN-ENATDRERTNFLS 1421

Query: 174  EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL------------------ 215
            EA +M+  D  +VV+  GV +  +P  V+MEL   G L S L                  
Sbjct: 1422 EASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNR 1481

Query: 216  ----GKLHFPMIKK-YELIYQAANGLAYIHEKNLMHRDVAARNCL 255
                G +  P   + Y++  + A+G+AY+  K  +HRD+AARNC+
Sbjct: 1482 IGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCM 1526


>UniRef50_C3XPN4 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3XPN4_BRAFL
          Length = 585

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 52/143 (36%), Positives = 76/143 (53%), Gaps = 7/143 (4%)

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTK-EQIKEIMREARLMRNL 181
           L +KLG+G+FG V KG            + VAVK  K E + + +   + ++E   M  L
Sbjct: 19  LYEKLGDGSFGVVRKGDWTTPGGCT---IPVAVKCLKNEVLVQPDAFMDFVKEVNAMHQL 75

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYI 239
           DH N+++ +GV   + PL ++ ELA  GAL   L K    FP+    E   Q ANG+AY+
Sbjct: 76  DHPNLIRLYGVVLSS-PLMMVTELAPKGALLDKLRKAGHRFPIATLCEYAIQIANGMAYL 134

Query: 240 HEKNLMHRDVAARNCLYGGGQVL 262
                +HRD+AARN L    +V+
Sbjct: 135 ESHRYIHRDLAARNILLASNEVV 157


>UniRef50_C5DPQ3 ZYRO0A05214p n=1 Tax=Zygosaccharomyces rouxii RepID=C5DPQ3_ZYGRO
          Length = 941

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 48/158 (30%), Positives = 89/158 (56%), Gaps = 9/158 (5%)

Query: 106 KQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTK 165
           +Q+V+++  +      +L + +G+G++G V+K      ++   Q  LVA+K    E+   
Sbjct: 20  EQSVKQEPQKRNQIQYQLKQVIGKGSYGVVYKA-----INRKTQK-LVAIKEVHYEN--D 71

Query: 166 EQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-FPMIK 224
           +++ +IM E  L++NL+HIN+VK+ G    +  LY+I+E    G+L + + + +  P  K
Sbjct: 72  DELTDIMSEIDLLKNLNHINIVKYHGFIQKSHNLYIILEYCSHGSLKNYISRGNGLPESK 131

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               + Q  NGL Y+HE+ ++HRD+ A N L     V+
Sbjct: 132 AKVYVKQTLNGLNYLHEQGVIHRDIKAANLLLDSNNVV 169


>UniRef50_O81809 MAP3K epsilon protein kinase n=9 Tax=Magnoliophyta
           RepID=O81809_ARATH
          Length = 1368

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 46/136 (33%), Positives = 78/136 (57%), Gaps = 9/136 (6%)

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L  ++G+GA+G V+KG  L+  D       VA+K   LE++ +E +  IM+E  L++NL+
Sbjct: 22  LGDEIGKGAYGRVYKGLDLENGD------FVAIKQVSLENIVQEDLNTIMQEIDLLKNLN 75

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHF-PMIKKYELIY--QAANGLAYI 239
           H N+VK+ G +     L++I+E  + G+L + +    F P  +    +Y  Q   GL Y+
Sbjct: 76  HKNIVKYLGSSKHKTHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYL 135

Query: 240 HEKNLMHRDVAARNCL 255
           HE+ ++HRD+   N L
Sbjct: 136 HEQGVIHRDIKGANIL 151


>UniRef50_UPI000176070B PREDICTED: v-ros UR2 sarcoma virus oncogene homolog 1 n=1 Tax=Danio
            rerio RepID=UPI000176070B
          Length = 1696

 Score = 80.5 bits (197), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 51/144 (35%), Positives = 79/144 (54%), Gaps = 10/144 (6%)

Query: 121  VELTKKLGEGAFGEVWKGKLLKILDANHQPVL-VAVKTAKLESMTKEQIKEIMREARLMR 179
            ++L + LG GAFGEV++G  +       +P   VA+KT + ++   E+  E ++EA LM 
Sbjct: 1157 LKLQRLLGSGAFGEVYEGVTVGSQINGVEPERKVAIKTLQKDASDYEK-TEFLKEAHLMS 1215

Query: 180  NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--------GKLHFPMIKKYELIYQ 231
              +H N+++  GV    EP Y+I+EL +GG L S L         K    +    ++   
Sbjct: 1216 QFNHPNILRLLGVCLLNEPHYLILELMEGGDLRSYLRGARPTNNHKELLSLSSLLDISLD 1275

Query: 232  AANGLAYIHEKNLMHRDVAARNCL 255
            AA G AY+   + +HRD+AARNCL
Sbjct: 1276 AATGCAYLERMHFVHRDIAARNCL 1299


>UniRef50_UPI00019252ED PREDICTED: similar to predicted protein n=1 Tax=Hydra
           magnipapillata RepID=UPI00019252ED
          Length = 686

 Score = 80.5 bits (197), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 53/159 (33%), Positives = 80/159 (50%), Gaps = 19/159 (11%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKL--LKILDANHQPVLVAVKTAKLESMTKEQIKE 170
           +WE+  + + +T+ LGEGAFG V K     LK  + NH    VAVK  K ++ T+ ++ +
Sbjct: 356 EWEVDRDCLHITETLGEGAFGVVVKADAVGLKKCEENH--TTVAVKMLKADA-TENELLD 412

Query: 171 IMREARLMRNLD-HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK---- 225
           ++ E   M+ +  HIN++ F G    ++P+YVI+E A  G L   L     PM       
Sbjct: 413 LLSEMETMKQIGRHINIINFLGCCTQSDPVYVIVEYAPNGNLRQFLRSKRPPMSDNGYRS 472

Query: 226 ---------YELIYQAANGLAYIHEKNLMHRDVAARNCL 255
                         Q A G+ Y+  K  +HRD+AARN L
Sbjct: 473 DPLLSVKDIVSFALQIAKGMEYLASKKCIHRDLAARNIL 511


>UniRef50_C4QVZ2 Putative uncharacterized protein n=1 Tax=Pichia pastoris GS115
           RepID=C4QVZ2_PICPG
          Length = 492

 Score = 80.5 bits (197), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 51/148 (34%), Positives = 79/148 (53%), Gaps = 8/148 (5%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E   +  EL ++LG+GAFG V+ G   K+ + +     VA+K   LES T + I+EI  E
Sbjct: 3   EFNADQFELFERLGKGAFGVVYHG-FDKVTNMH-----VAIKQIDLES-TDDSIEEIQNE 55

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAAN 234
             L+ N  H N++++ G       L+++ME  DGG+ +  L    F   +   + Y    
Sbjct: 56  ITLLSNCSHPNIIQYHGSFVKGYKLWIVMEYLDGGSCNDLLEAGPFDETEISVICYNLLQ 115

Query: 235 GLAYIHEKNLMHRDVAARNCLYGG-GQV 261
           GLAY+H+   +HRD+ A N + G  GQV
Sbjct: 116 GLAYLHKSGKIHRDIKAANIMIGRLGQV 143


>UniRef50_Q170Z1 Tyrosine-protein kinase receptor (Fragment) n=1 Tax=Aedes aegypti
            RepID=Q170Z1_AEDAE
          Length = 2073

 Score = 80.5 bits (197), Expect = 6e-14,   Method: Composition-based stats.
 Identities = 52/152 (34%), Positives = 82/152 (53%), Gaps = 15/152 (9%)

Query: 115  ELYHEDVELTKK--LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            ++  E + +T    LG GAFGEV++G +  +         VA+KT + +  T+++  E +
Sbjct: 1804 QIRREQISMTSSPFLGSGAFGEVYEGIVKGV--GGEAETRVAIKTLR-KGATEQEKAEFL 1860

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP------MIKKY 226
            +EA LM N  H +++K  GV    + LY++MEL  GG L S L + + P      M+   
Sbjct: 1861 QEAHLMSNFKHKHILKLIGVCLDLDSLYIVMELMQGGDLLSYL-RSNRPTPGNPSMLTLL 1919

Query: 227  ELI---YQAANGLAYIHEKNLMHRDVAARNCL 255
            +LI      A G  Y+ E + +HRD+A RNCL
Sbjct: 1920 DLISMCVDVATGCRYLEEMHFVHRDLACRNCL 1951


>UniRef50_A8NSH8 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea
           okayama7#130 RepID=A8NSH8_COPC7
          Length = 1265

 Score = 80.5 bits (197), Expect = 6e-14,   Method: Compositional matrix adjust.
 Identities = 47/135 (34%), Positives = 76/135 (56%), Gaps = 7/135 (5%)

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
           +L   LG+GAFG+V++    +  +       VAVK  +L ++ K ++ EIM E  L++NL
Sbjct: 25  QLGDSLGKGAFGQVYRALNWETGET------VAVKEIQLSNIPKGELPEIMSEIDLLKNL 78

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIH 240
           +H N+VK+ G     E LY+I+E  + G+L + + K   FP       I Q   GL Y+H
Sbjct: 79  NHENIVKYKGFVKTREFLYIILEFCENGSLHNIIKKFGKFPENLVAVYISQVLEGLVYLH 138

Query: 241 EKNLMHRDVAARNCL 255
           ++ ++HRD+   N L
Sbjct: 139 DQGVIHRDIKGANIL 153


>UniRef50_C1EGF7 Predicted protein n=1 Tax=Micromonas sp. RCC299 RepID=C1EGF7_9CHLO
          Length = 1032

 Score = 80.1 bits (196), Expect = 6e-14,   Method: Composition-based stats.
 Identities = 49/143 (34%), Positives = 81/143 (56%), Gaps = 15/143 (10%)

Query: 119 EDV-ELTKKLGEGAFGEVWKGKLLKILDANHQP--VLVAVKTAKLESMTKEQIKEIMREA 175
           ED+ EL ++LG+G++G V+K        A H+P   +VAVK   L    +E +++I RE 
Sbjct: 8   EDLFELLEQLGKGSYGAVYK--------ARHRPSGTIVAVKVIPLSGEDEEGLEDIRREI 59

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY---QA 232
            ++R   H NVV++FG   GTE L+++ME   GG++   L   + P+ ++ ++ Y   + 
Sbjct: 60  AVLRECVHPNVVRYFGSFTGTEYLWIVMEHCGGGSVRDILSASNRPL-REAQIAYLCGET 118

Query: 233 ANGLAYIHEKNLMHRDVAARNCL 255
             GL Y+H    +HRD+   N L
Sbjct: 119 LKGLVYLHSIFKVHRDIKCSNIL 141


>UniRef50_P29323 Ephrin type-B receptor 2 n=364 Tax=Eumetazoa RepID=EPHB2_HUMAN
          Length = 1055

 Score = 80.1 bits (196), Expect = 7e-14,   Method: Composition-based stats.
 Identities = 48/137 (35%), Positives = 78/137 (56%), Gaps = 6/137 (4%)

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V++ + +G G FGEV  G L K+     + + VA+KT K    T++Q ++ + EA +M  
Sbjct: 621 VKIEQVIGAGEFGEVCSGHL-KL--PGKREIFVAIKTLK-SGYTEKQRRDFLSEASIMGQ 676

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAY 238
            DH NV+   GV   + P+ +I E  + G+LDS L +    F +I+   ++   A G+ Y
Sbjct: 677 FDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKY 736

Query: 239 IHEKNLMHRDVAARNCL 255
           + + N +HRD+AARN L
Sbjct: 737 LADMNYVHRDLAARNIL 753


>UniRef50_B0XJJ2 Testis-specific serine/threonine-protein kinase 6 n=1 Tax=Culex
           quinquefasciatus RepID=B0XJJ2_CULQU
          Length = 590

 Score = 80.1 bits (196), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 57/164 (34%), Positives = 82/164 (50%), Gaps = 17/164 (10%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILD-ANHQPVLVAVKTAKLESMTKEQIKEI 171
           +WEL  + + L K LGEGAFG V +GK     + AN  P  VAVK  + E+ T E +K++
Sbjct: 310 RWELPRQRIVLGKLLGEGAFGRVVQGKASGFAEGANSIP--VAVKMLR-ENHTDEDVKDL 366

Query: 172 MREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHF---------- 220
           + E  +M+ +  H NV+   G  +   PLYVI+E A  G L + L    F          
Sbjct: 367 VCELEIMKMIGKHPNVISLVGCCSNKGPLYVIIEYATHGNLKNFLRGFRFEGSFDKLDKQ 426

Query: 221 --PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              + +      Q A G+ Y+     +HRD+AARN L   G V+
Sbjct: 427 AISVQRLVTFALQIATGMEYLSSIKCIHRDLAARNILVSEGYVM 470


>UniRef50_Q9UM73 ALK tyrosine kinase receptor n=79 Tax=root RepID=ALK_HUMAN
          Length = 1620

 Score = 80.1 bits (196), Expect = 8e-14,   Method: Composition-based stats.
 Identities = 49/150 (32%), Positives = 84/150 (56%), Gaps = 12/150 (8%)

Query: 115  ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK-EIMR 173
            E+  +++ L + LG GAFGEV++G++  + + +  P+ VAVKT  L  +  EQ + + + 
Sbjct: 1110 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPN-DPSPLQVAVKT--LPEVCSEQDELDFLM 1166

Query: 174  EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIKK 225
            EA ++   +H N+V+  GV+  + P ++++EL  GG L S L +            M+  
Sbjct: 1167 EALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDL 1226

Query: 226  YELIYQAANGLAYIHEKNLMHRDVAARNCL 255
              +    A G  Y+ E + +HRD+AARNCL
Sbjct: 1227 LHVARDIACGCQYLEENHFIHRDIAARNCL 1256


>UniRef50_UPI00017930FA PREDICTED: similar to protein kinase protein n=1 Tax=Acyrthosiphon
           pisum RepID=UPI00017930FA
          Length = 934

 Score = 79.7 bits (195), Expect = 8e-14,   Method: Composition-based stats.
 Identities = 46/143 (32%), Positives = 85/143 (59%), Gaps = 7/143 (4%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI-KEIMRE 174
           +  +D++L++K+G+G+FG V +G+      +  + V VAVK  K +  +  Q+ ++ ++E
Sbjct: 116 ILEKDIKLSEKIGDGSFGIVSRGEWTT---STGRVVQVAVKMLKQDVPSLPQMFEDFVKE 172

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQA 232
            + M  LDH++++K +G+   T+P+ ++ ELA  G+L   L K   H  +   +E   Q 
Sbjct: 173 VQAMHTLDHVHLIKLYGIVL-TQPMMMVTELAALGSLRDYLRKQCGHIMITDLWEYALQV 231

Query: 233 ANGLAYIHEKNLMHRDVAARNCL 255
           A G+ Y+ +K  +HRD+A RN L
Sbjct: 232 ATGMEYLEKKRCIHRDLACRNIL 254


>UniRef50_Q07912 Activated CDC42 kinase 1 n=46 Tax=Euteleostomi RepID=ACK1_HUMAN
          Length = 1038

 Score = 79.7 bits (195), Expect = 8e-14,   Method: Composition-based stats.
 Identities = 52/141 (36%), Positives = 82/141 (58%), Gaps = 9/141 (6%)

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDA-NHQPVLVAVKTAKLESMTK-EQIKEIMREAR 176
           +D+ L +KLG+G+FG V +G+     DA + + V VAVK  K + +++ E + + +RE  
Sbjct: 124 KDLRLLEKLGDGSFGVVRRGEW----DAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 179

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAAN 234
            M +LDH N+++ +GV   T P+ ++ ELA  G+L   L K   HF +        Q A 
Sbjct: 180 AMHSLDHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 238

Query: 235 GLAYIHEKNLMHRDVAARNCL 255
           G+ Y+  K  +HRD+AARN L
Sbjct: 239 GMGYLESKRFIHRDLAARNLL 259


>UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata RepID=TEC_HUMAN
          Length = 631

 Score = 79.7 bits (195), Expect = 8e-14,   Method: Compositional matrix adjust.
 Identities = 66/266 (24%), Positives = 122/266 (45%), Gaps = 25/266 (9%)

Query: 5   DLLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           +L   ++Y   + R   +++L   +K G F++R S               GE  +   H+
Sbjct: 241 NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY 300

Query: 62  VVRE---SDHKVYV-DKIGFPTIIELVNHY------VSTKESFSTKDGTVKAVLKQAVER 111
            ++E   S  K Y+ +K  F +I E++ ++      + T+  +        A        
Sbjct: 301 HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY 360

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
           +KWE+   ++   ++LG G FG V  GK      A ++   VA+K  +  +M +E   + 
Sbjct: 361 EKWEINPSELTFMRELGSGLFGVVRLGKW----RAQYK---VAIKAIREGAMCEE---DF 410

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELI 229
           + EA++M  L H  +V+ +GV    +P+Y++ E  + G L + L +   HF       + 
Sbjct: 411 IEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMC 470

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCL 255
                G+ Y+   + +HRD+AARNCL
Sbjct: 471 QDVCEGMEYLERNSFIHRDLAARNCL 496


>UniRef50_B3XVW0 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVW0_9EUKA
          Length = 954

 Score = 79.7 bits (195), Expect = 8e-14,   Method: Composition-based stats.
 Identities = 46/146 (31%), Positives = 80/146 (54%), Gaps = 9/146 (6%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
           ++W     +++L  +LG GA+G+V++ + + +  A+   + VA KT   E+     ++EI
Sbjct: 673 KRWNFPRSNLKLVNELGSGAYGKVYRYEAIGLGPAS---ISVAAKTCTDEANQSRFLQEI 729

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELI 229
                LM++L H ++V+         P  +I+E    G+LD  L   K+     +   ++
Sbjct: 730 ----ELMKSLRHPHIVQMLAACTSDGPPLMILEFMAEGSLDHFLRRPKVQLTTTELQSIL 785

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCL 255
           +QAA  LAYI  + L+HRDV+ARNCL
Sbjct: 786 FQAATALAYITSRQLVHRDVSARNCL 811



 Score = 63.5 bits (153), Expect = 7e-09,   Method: Composition-based stats.
 Identities = 46/143 (32%), Positives = 67/143 (46%), Gaps = 6/143 (4%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           EL    +  T  LG G FG V +  L    + +     VA K  K ++ +  +    + E
Sbjct: 388 ELDRSKLRFTTPLGYGFFGIVKRATLT---NPDGSTTTVAGKQLK-DTASPAEEDAFLNE 443

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQA 232
              +  L H NVV+ +G    ++P+++IMEL   G+L   L              L+   
Sbjct: 444 IHKVSQLSHPNVVRSYGAITRSKPMFLIMELCSEGSLHDMLKANDKRLDQRTSITLLKDF 503

Query: 233 ANGLAYIHEKNLMHRDVAARNCL 255
           A GL YI   N++HRDVAARNCL
Sbjct: 504 ALGLEYIAGLNIVHRDVAARNCL 526


>UniRef50_Q14289 Protein-tyrosine kinase 2-beta n=51 Tax=Euteleostomi
           RepID=FAK2_HUMAN
          Length = 1009

 Score = 79.7 bits (195), Expect = 8e-14,   Method: Compositional matrix adjust.
 Identities = 60/180 (33%), Positives = 92/180 (51%), Gaps = 18/180 (10%)

Query: 92  ESFSTKDGTVKAVLKQAVERQ---KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANH 148
           ES S +      +  + + R    ++ +  EDV L + LGEG FGEV++G     +  NH
Sbjct: 393 ESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEG-----VYTNH 447

Query: 149 --QPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELA 206
             + + VAVKT K +  T +  ++ M EA +M+NLDH ++VK  G+    EP ++IMEL 
Sbjct: 448 KGEKINVAVKTCK-KDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIE-EEPTWIIMELY 505

Query: 207 DGGALDSALGK----LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             G L   L +    L    +  Y L  Q    +AY+   N +HRD+A RN L    + +
Sbjct: 506 PYGELGHYLERNKNSLKVLTLVLYSL--QICKAMAYLESINCVHRDIAVRNILVASPECV 563


>UniRef50_C4M8T8 Protein kinase, putative n=3 Tax=Entamoeba RepID=C4M8T8_ENTHI
          Length = 457

 Score = 79.7 bits (195), Expect = 9e-14,   Method: Compositional matrix adjust.
 Identities = 47/135 (34%), Positives = 75/135 (55%), Gaps = 8/135 (5%)

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
           T +LGEGAF  V  G+++K  +       VA+K    + + ++Q++ I RE +LMR L H
Sbjct: 169 TSELGEGAFSIVVAGEIIKTKER------VAIKKITKKDIPEDQLEMIKREIQLMRQLHH 222

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIHEKN 243
            N+VK F V    E LY+I+E  +GG L   L +      +   ++YQ  + + Y+H+ N
Sbjct: 223 KNIVKLFDVYENNEILYLILEYVEGGELYDRLVQGALNERQAACVLYQLVSAITYLHKNN 282

Query: 244 LMHRDVAARN--CLY 256
           + HRD+   N  C+Y
Sbjct: 283 IAHRDLKPENILCVY 297


>UniRef50_Q9GRH2 Tyrosine-protein kinase receptor n=1 Tax=Sycon raphanus
           RepID=Q9GRH2_9METZ
          Length = 616

 Score = 79.7 bits (195), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 53/181 (29%), Positives = 86/181 (47%), Gaps = 27/181 (14%)

Query: 105 LKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMT 164
           L+  VE   WEL  + + + +++GEGAFG+V++G L  + D +   + VA+KT  +   T
Sbjct: 201 LEDYVEDPAWELVPDSLTMIREVGEGAFGKVYEGLLATVEDGD---MTVAIKTLSVCD-T 256

Query: 165 KEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGAL------------- 211
             Q    + EA +M+  D   V++  G+ +      V+ME    G L             
Sbjct: 257 MGQRNAFLAEASIMKKFDSPYVMRLMGLVSTENKPLVVMEFMAEGDLRGYVRKCRPQNRQ 316

Query: 212 ---------DSALGKLHFPMIKKYEL-IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
                     SA      P  +++ L   Q + G+AY+HEK+ +HRD+AARNC+      
Sbjct: 317 FSINSIETNGSAASVYGIPTAERFMLWALQLSKGMAYVHEKHFVHRDLAARNCMLSSNLT 376

Query: 262 L 262
           L
Sbjct: 377 L 377


>UniRef50_B3RT16 Tyrosine-protein kinase receptor (Fragment) n=1 Tax=Trichoplax
           adhaerens RepID=B3RT16_TRIAD
          Length = 449

 Score = 79.7 bits (195), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 52/161 (32%), Positives = 86/161 (53%), Gaps = 18/161 (11%)

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE   E + L K+LG+GAFG V+ G+   I+    +   VAVKT   ++  +E+ +E + 
Sbjct: 7   WEFEREKIALLKELGKGAFGMVYLGEAADIIYGELK-TKVAVKTVNEKASFRER-QEFLN 64

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--------------- 218
           EA +M+  D  +VV+  G+ +   P  VIMEL   G L + L  L               
Sbjct: 65  EACIMKQFDCNHVVRLLGIVSQGLPPLVIMELMANGDLKNHLRSLREDADSPDYYLKPNP 124

Query: 219 HFPM-IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           + P  ++ +++  + A+G+ Y+ +K  +HRD+AARNC+  G
Sbjct: 125 NRPSDVQFHKMAAEIADGMLYLSDKKFVHRDLAARNCMVSG 165


>UniRef50_O97191 Tyrosine-protein kinase receptor n=1 Tax=Geodia cydonium
           RepID=O97191_GEOCY
          Length = 570

 Score = 79.7 bits (195), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 55/159 (34%), Positives = 82/159 (51%), Gaps = 18/159 (11%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           L  + + LT+ LGEGAFG V+KG + K  D + + V VA+KT K  S  +E I   ++E+
Sbjct: 264 LAEDQLILTESLGEGAFGRVYKGSM-KTGDDDDRTVEVAIKTLKDISQ-QENIDNFVQES 321

Query: 176 RLMRNLDHINVVKFFGVAAGTE---PLYVIMELADGGALDSALGK---------LHFPMI 223
            LM   +H NV++  GV   T    PL V+  +A+G      + K          HFP  
Sbjct: 322 ILMLGFNHPNVLELLGVCFDTTDRHPLIVLPFMANGDLRSYLMSKRDPSVTTKFTHFPQG 381

Query: 224 KKYE----LIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
              E    +  + A G+ Y+   + +HRD+AARNC+  G
Sbjct: 382 LDEERALVMCLEVARGMEYLSNSSFVHRDLAARNCMVSG 420


>UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2 Tax=Eumetazoa
           RepID=UPI0001925126
          Length = 914

 Score = 79.7 bits (195), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 67/271 (24%), Positives = 133/271 (49%), Gaps = 45/271 (16%)

Query: 11  YYHGLLPREDIQEMLNKP--GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVR-ESD 67
           +YH  + R++  +++     G FL+R +   K     F    V        H+ ++ +SD
Sbjct: 547 WYHADMTRQEADQVMQNTNDGTFLVRNASKPKMYTLSFSFQGV------VKHYHIKTDSD 600

Query: 68  HKVYVD-KIGFPTIIELVNHY------VSTKESFS-TKDGTVKAVLKQAVERQKWELYHE 119
           +  YV  +  F ++++L+ ++      ++T+  F  T       +L   V    +++   
Sbjct: 601 NLFYVSQRHSFESVVQLIEYHKLNSAGLATRLRFPYTGTNNPPVLLGYGV----FQINRN 656

Query: 120 DVELTKKLGEGAFGEV----WKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           ++ + K++G G FG V    WK              LVAVK  K +SM++    + + EA
Sbjct: 657 ELTIMKQIGTGQFGTVHEALWKNN-----------KLVAVKMMKPDSMSE---NDFIEEA 702

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK----YELIYQ 231
           ++M+   H N++  +GV   T PLY+++EL   G+L   L + +  +++K     ++I +
Sbjct: 703 KVMQRFQHRNLITLYGVCT-THPLYIVVELMKNGSLLDYL-RNNKQLLEKTQVLIDIILK 760

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            ++ + Y+ +   +HRD+AARNCL G   ++
Sbjct: 761 VSSAMEYLEKNKFIHRDLAARNCLVGENNMI 791


>UniRef50_UPI000186D702 tyrosine-protein kinase pr2, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186D702
          Length = 1156

 Score = 79.7 bits (195), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 46/141 (32%), Positives = 76/141 (53%), Gaps = 9/141 (6%)

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           E + + K+LG+G FG V +G    +       + VA+K    E M    I E ++EA +M
Sbjct: 113 ESIVVNKELGQGEFGTVQQG----VWTDEDDRIQVAIKCLSREKMQNNPI-EFLKEAAIM 167

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG----KLHFPMIKKYELIYQAAN 234
             +DH ++V+ +GV   T  L ++ ELA   +L   L     + +FP++   +   Q  +
Sbjct: 168 HGIDHEHIVRLYGVVLDTNSLMLVTELAPLRSLLECLKEPSLRCNFPVLSLCDFAIQVCD 227

Query: 235 GLAYIHEKNLMHRDVAARNCL 255
           G+ Y+ +K L+HRD+AARN L
Sbjct: 228 GMQYLEQKRLIHRDLAARNIL 248


>UniRef50_A9SD09 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9SD09_PHYPA
          Length = 1243

 Score = 79.3 bits (194), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 48/138 (34%), Positives = 77/138 (55%), Gaps = 13/138 (9%)

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L  ++G+GA+G V+KG  L+  D       VA+K   LE++  E +  IM E  L++NL+
Sbjct: 22  LGDEIGKGAYGRVYKGLDLENGD------FVAIKQVSLENIPPEDLASIMSEIDLLKNLN 75

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSAL-----GKLHFPMIKKYELIYQAANGLA 237
           H N+VK+ G       LY+I+E  + G+L + +     G L   ++ +Y  I Q   GL 
Sbjct: 76  HRNIVKYQGSFKTKTHLYIILEFVENGSLANNIKPNKFGALPENVVGRY--IAQVLEGLV 133

Query: 238 YIHEKNLMHRDVAARNCL 255
           Y+HE+ ++HRD+   N L
Sbjct: 134 YLHEQGVIHRDIKGANIL 151


>UniRef50_C4R9I2 Tyrosine kinase non-receptor n=10 Tax=Euteleostomi RepID=C4R9I2_PIG
          Length = 1037

 Score = 79.3 bits (194), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 52/141 (36%), Positives = 82/141 (58%), Gaps = 9/141 (6%)

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDA-NHQPVLVAVKTAKLESMTK-EQIKEIMREAR 176
           +D+ L +KLG+G+FG V +G+     DA + + V VAVK  K + +++ E + + +RE  
Sbjct: 124 KDLHLFEKLGDGSFGVVRRGEW----DAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 179

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAAN 234
            M +LDH N+++ +GV   T P+ ++ ELA  G+L   L K   HF +        Q A 
Sbjct: 180 AMHSLDHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 238

Query: 235 GLAYIHEKNLMHRDVAARNCL 255
           G+ Y+  K  +HRD+AARN L
Sbjct: 239 GMGYLESKRFIHRDLAARNLL 259


>UniRef50_Q4SQX3 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SQX3_TETNG
          Length = 780

 Score = 79.3 bits (194), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 50/151 (33%), Positives = 84/151 (55%), Gaps = 6/151 (3%)

Query: 107 QAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKE 166
           QAV     E+    +++ K +G G FGEV  G++        + + VA+KT K+   T++
Sbjct: 401 QAVHEFAREIEASRIKIEKIIGSGEFGEVCYGRMRL---PGKRDIPVALKTLKV-GYTEK 456

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIK 224
           Q ++ + EA +M   DH NV++  GV   ++P+ +I E  + G+LDS L +    F +I+
Sbjct: 457 QKRDFLAEASIMAQFDHPNVIRLEGVVTHSKPVMIITEYMENGSLDSFLRRHDGQFTIIQ 516

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
              L+   A G+ Y+ +   +HRD+AARN L
Sbjct: 517 LVGLLRGIAAGMTYLSDLGYIHRDLAARNIL 547


>UniRef50_C9DED1 Fibroblast growth factor receptor B n=1 Tax=Saccoglossus
           kowalevskii RepID=C9DED1_SACKO
          Length = 928

 Score = 79.3 bits (194), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 22/169 (13%)

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+  + +EL + LGEGAFG+V K +   I     +   VAVK  K+ S T+ ++ +++ 
Sbjct: 534 WEIPRDKLELKEPLGEGAFGQVIKAEAKGIF-GKDKTTTVAVKMLKV-SATERELSDLVH 591

Query: 174 EARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP----------M 222
           E  +M+ +  H+N++   G +    PLYV++E A  G L   L     P          +
Sbjct: 592 EMEMMKTIGKHLNIINLIGCSTQDGPLYVVVEFAPHGNLRDFLRSKRPPNPDYDCEKTRL 651

Query: 223 IKKYE---------LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +  YE           YQ A  + ++  K  +HRD+AARN L     ++
Sbjct: 652 VNNYEPLLNKHLVSFAYQIAKAMEFLSSKRCIHRDLAARNVLVAENNIM 700


>UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E52F9
          Length = 588

 Score = 79.3 bits (194), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 69/268 (25%), Positives = 122/268 (45%), Gaps = 38/268 (14%)

Query: 11  YYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVV-------GEKKTSANH 60
           +Y   + R   QE+L    K G F++R S         + +SV        GEK     H
Sbjct: 213 WYSKNMNRMQAQELLMREGKEGAFMVRDS----SHMGVYTVSVFTKAPSQSGEKNPKVKH 268

Query: 61  FVVRESDHKV----YVDKIGFPTIIELVNHYVSTKESFSTK-------DGTVKAVLKQAV 109
           + +R+++         +   F TI EL++++        T+       DG+    +    
Sbjct: 269 YQIRQTETGAGPFYLAENYLFNTIPELIHYHQHNAAGLITRLRHPVSPDGSSAQQVSAPF 328

Query: 110 ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
           E  +WEL  +++ L +++G G FG V        L+   +   VAVK  +   M+++ ++
Sbjct: 329 EADQWELNPDELTLGQEIGSGQFGLV--------LEGWWKKKKVAVKMIRDGCMSEDDLQ 380

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK--YE 227
           E   EAR+M  L H  +V+ + V++   PL ++ E  + G L   L      + ++    
Sbjct: 381 E---EARVMMKLSHHKLVQLYAVSSQRSPLCLVFEFMENGCLSDYLRARKGSLSQETLLN 437

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCL 255
           +    + G+AY+   N +HRD+AARNCL
Sbjct: 438 MCMDVSEGMAYLESSNFLHRDLAARNCL 465


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score = 79.0 bits (193), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 74/264 (28%), Positives = 125/264 (47%), Gaps = 43/264 (16%)

Query: 11  YYHGLLPREDIQEMLNKP--GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDH 68
           ++HG + RE  + +L  P  G FL+R S    G+   + L V  + K    H+ +     
Sbjct: 82  WFHGKITREQAERLLYPPETGLFLVRESTNYPGD---YTLCVSCDGKV--EHYRIMYHAS 136

Query: 69  KVYVDK-IGFPTIIELVNHYVSTKESFSTK-------DGTVKAVLKQAVERQKWELYHED 120
           K+ +D+ + F  +++LV HY S  +   T+       +GTV A  +    R  W L  ++
Sbjct: 137 KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAA--QDEFYRSGWALNMKE 194

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           ++L + +G+G FG+V  G        +++   VAVK  K ++  +      + EA +M  
Sbjct: 195 LKLLQTIGKGEFGDVMLG--------DYRGNKVAVKCIKNDATAQA----FLAEASVMTQ 242

Query: 181 LDHINVVKFFGVAAGTEP-LYVIME-LADGGALD-------SALGKLHFPMIKKYELIYQ 231
           L H N+V+  GV    +  LY++ E +A G  +D       S LG      + K+ L   
Sbjct: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG---DCLLKFSL--D 297

Query: 232 AANGLAYIHEKNLMHRDVAARNCL 255
               + Y+   N +HRD+AARN L
Sbjct: 298 VCEAMEYLEGNNFVHRDLAARNVL 321


>UniRef50_A7TJU8 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora
           DSM 70294 RepID=A7TJU8_VANPO
          Length = 977

 Score = 79.0 bits (193), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 51/174 (29%), Positives = 90/174 (51%), Gaps = 16/174 (9%)

Query: 90  TKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQ 149
           + E  S K+    + +KQ+  R +++L          +G+G+FG V+K    K    N  
Sbjct: 39  STEVESIKETQEASAVKQSQPRIQYQL-------KAVIGKGSFGVVYKAVNRK---TNQ- 87

Query: 150 PVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGG 209
             +VA+K    ++   E++ +IM E  L++NL+H+N+VK+ G     + LY+I+E    G
Sbjct: 88  --VVAIKEVNYDN--DEELNDIMSEIHLLKNLNHVNIVKYHGFIQKMDTLYIILEYCSRG 143

Query: 210 ALDSALG-KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +L   +      P I+    I Q   GL+Y+HE+ ++HRD+ + N L     V+
Sbjct: 144 SLKKLISPNRGIPEIEAQSYIRQTLQGLSYLHEQGVIHRDIKSANLLLDSSNVV 197


>UniRef50_UPI000186D99E conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186D99E
          Length = 1007

 Score = 79.0 bits (193), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 46/140 (32%), Positives = 83/140 (59%), Gaps = 7/140 (5%)

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI-KEIMREARL 177
           +D+  + KLG+G+FG V KG+ +         + VA+K  K +++T+  + ++  +E + 
Sbjct: 114 KDLTQSVKLGDGSFGIVRKGEWVT---PTGNVINVALKILKQDALTQPGVFEDFFKEVQA 170

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPM--IKKYELIYQAANG 235
           M +L+H N+++ +G+   ++PL ++ ELA  G+L   L K +F M  +K Y+   Q A G
Sbjct: 171 MHSLNHTNLIRLYGIVL-SQPLMMVTELAPLGSLLDYLRKHNFQMSLLKIYDYALQVAAG 229

Query: 236 LAYIHEKNLMHRDVAARNCL 255
           + Y+  K  +HRD+A RN L
Sbjct: 230 MQYLESKRFIHRDLACRNVL 249


>UniRef50_UPI000175855D PREDICTED: similar to focal adhesion kinase n=1 Tax=Tribolium
           castaneum RepID=UPI000175855D
          Length = 1134

 Score = 79.0 bits (193), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 51/146 (34%), Positives = 82/146 (56%), Gaps = 7/146 (4%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
           + +EL  + ++L + LGEG FG+V KG   K  D +  PV  AVKT K E+      ++ 
Sbjct: 419 KSYELQRDQIQLGEILGEGQFGDVHKGTY-KAKDGSLIPV--AVKTCKREA-DLNTTEKF 474

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELI 229
           + EA +M+  DH +++K  GV + + P++++MELA  G L + L   K    +       
Sbjct: 475 LEEAYIMQKFDHQHIIKLIGVCSES-PVWIVMELAKLGELRAYLQNNKDDLDLATLLLYA 533

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCL 255
           +Q +  L+Y+  K  +HRD+AARN L
Sbjct: 534 FQLSTALSYLESKKFVHRDIAARNVL 559


>UniRef50_D1I166 Whole genome shotgun sequence of line PN40024,
           scaffold_11.assembly12x (Fragment) n=7 Tax=Magnoliophyta
           RepID=D1I166_VITVI
          Length = 1396

 Score = 79.0 bits (193), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 46/136 (33%), Positives = 77/136 (56%), Gaps = 9/136 (6%)

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L  ++G+GA+G V+KG  L+  D       VA+K   LE++ +E +  IM+E  L++NL+
Sbjct: 22  LGDEIGKGAYGRVYKGLDLENGD------FVAIKQVSLENIAQEDLNIIMQEIDLLKNLN 75

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHF-PMIKKYELIY--QAANGLAYI 239
           H N+VK+ G       L++I+E  + G+L + +    F P  +    +Y  Q   GL Y+
Sbjct: 76  HKNIVKYLGSLKTRSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYISQVLEGLVYL 135

Query: 240 HEKNLMHRDVAARNCL 255
           HE+ ++HRD+   N L
Sbjct: 136 HEQGVIHRDIKGANIL 151


>UniRef50_Q7Z1D3 Focal adhesion kinase n=1 Tax=Lytechinus variegatus
           RepID=Q7Z1D3_LYTVA
          Length = 1006

 Score = 79.0 bits (193), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 53/145 (36%), Positives = 81/145 (55%), Gaps = 10/145 (6%)

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           +E+  E V L + +G+G FG+V KG    I     + V VAVKT K+ES T+   +  + 
Sbjct: 431 YEISRELVTLVETIGQGQFGDVHKG----IYIDQDEKVEVAVKTCKVES-TQALGERFLE 485

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELI---Y 230
           EA +M+  DH +++K  GV     P++++MELA  G +   L + H   +    LI   Y
Sbjct: 486 EAYIMKQFDHPHIIKLIGVCTDP-PIWIVMELAPFGEMRMFL-QTHKEELTLASLILYAY 543

Query: 231 QAANGLAYIHEKNLMHRDVAARNCL 255
           Q +  L+Y+  K  +HRD+AARN L
Sbjct: 544 QLSMALSYLESKKFVHRDIAARNLL 568


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q18865 Putative uncharacterized protein n=6 Tax=Caenorh...   397   e-109
UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorh...   330   2e-89
UniRef50_Q18684 Protein T13H10.1, confirmed by transcript eviden...   315   6e-85
UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA    311   2e-83
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...   311   2e-83
UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateri...   303   5e-81
UniRef50_P34265 Probable tyrosine-protein kinase kin-31 n=4 Tax=...   302   1e-80
UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, part...   302   1e-80
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   301   2e-80
UniRef50_Q20933 Putative uncharacterized protein n=1 Tax=Caenorh...   300   3e-80
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   300   4e-80
UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=...   299   5e-80
UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria...   299   6e-80
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   299   7e-80
UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax...   297   3e-79
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   295   8e-79
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   295   8e-79
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          295   8e-79
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          295   8e-79
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   295   8e-79
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...   295   9e-79
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...   292   8e-78
UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1...   292   9e-78
UniRef50_A8WMP8 Putative uncharacterized protein n=1 Tax=Caenorh...   292   1e-77
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   290   2e-77
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   289   8e-77
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   288   2e-76
UniRef50_UPI000186DA97 tyrosine-protein kinase transforming prot...   287   2e-76
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   286   5e-76
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...   284   2e-75
UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76...   283   4e-75
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   282   6e-75
UniRef50_C4Q4A1 Term=tyrosine kinase 5;db_xref=PMID:11289068;wit...   281   1e-74
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   281   2e-74
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...   281   2e-74
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...   280   2e-74
UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax...   280   3e-74
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   280   5e-74
UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepI...   278   1e-73
UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes relate...   278   1e-73
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   278   1e-73
UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephyd...   278   2e-73
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...   277   3e-73
UniRef50_A8XAK9 Putative uncharacterized protein n=1 Tax=Caenorh...   276   6e-73
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   275   9e-73
UniRef50_Q7YSY1 Fes-like tyrosine kinase protein n=5 Tax=Schisto...   275   9e-73
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...   275   1e-72
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...   274   2e-72
UniRef50_A8PMN8 Protein kinase domain containing protein n=1 Tax...   274   2e-72
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   274   2e-72
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...   273   3e-72
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...   273   3e-72
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...   273   4e-72
UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia mal...   273   4e-72
UniRef50_Q4S351 Chromosome 4 SCAF14752, whole genome shotgun seq...   273   5e-72
UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni ...   272   7e-72
UniRef50_O17755 Protein F01D4.3, partially confirmed by transcri...   269   6e-71
UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Su...   269   6e-71
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...   268   1e-70
UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidenc...   268   1e-70
UniRef50_Q23554 Putative uncharacterized protein n=1 Tax=Caenorh...   268   1e-70
UniRef50_Q9TYX4 Putative uncharacterized protein R11E3.1 n=3 Tax...   267   3e-70
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...   267   3e-70
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...   267   3e-70
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...   266   4e-70
UniRef50_Q9N4T6 Putative uncharacterized protein n=1 Tax=Caenorh...   266   5e-70
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...   266   6e-70
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...   265   7e-70
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...   265   1e-69
UniRef50_O01798 Defective spermatogenesis protein 8 n=3 Tax=Caen...   264   2e-69
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...   264   2e-69
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   262   1e-68
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE     260   3e-68
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...   260   3e-68
UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax...   260   3e-68
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...   259   7e-68
UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera...   258   1e-67
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   256   4e-67
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...   256   5e-67
UniRef50_Q22765 Protein T25B9.4, partially confirmed by transcri...   255   9e-67
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...   254   2e-66
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...   254   3e-66
UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative ...   253   5e-66
UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein ...   252   7e-66
UniRef50_A8PJL3 Protein kinase domain containing protein n=1 Tax...   252   7e-66
UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata R...   251   2e-65
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...   251   2e-65
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...   250   4e-65
UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosi...   249   6e-65
UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun se...   249   6e-65
UniRef50_A8Q767 Protein kinase domain containing protein n=1 Tax...   249   9e-65
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...   248   1e-64
UniRef50_P91360 Putative uncharacterized protein n=3 Tax=root Re...   248   1e-64
UniRef50_A8NEQ9 Protein kinase domain containing protein (Fragme...   248   1e-64
UniRef50_Q19726 Protein F22D6.1, partially confirmed by transcri...   246   5e-64
UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia ...   244   3e-63
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...   243   6e-63
UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes...   242   1e-62
UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona inte...   241   1e-62
UniRef50_A8Q7I8 Protein kinase domain containing protein n=1 Tax...   241   2e-62
UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californic...   240   4e-62
UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   240   5e-62
UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2...   240   5e-62
UniRef50_A8QBK0 Protein kinase domain containing protein n=1 Tax...   239   8e-62
UniRef50_A8XFQ1 Putative uncharacterized protein n=2 Tax=Caenorh...   235   2e-60
UniRef50_UPI00004D86FC Tyrosine-protein kinase Tec (EC 2.7.10.2)...   234   2e-60
UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase...   232   8e-60
UniRef50_Q21764 Protein R05H5.4, partially confirmed by transcri...   232   1e-59
UniRef50_A8WPD7 Putative uncharacterized protein n=4 Tax=Caenorh...   230   4e-59
UniRef50_Q9XXE5 Protein Y43C5B.2, partially confirmed by transcr...   228   2e-58
UniRef50_A8QEG4 Protein kinase domain containing protein n=1 Tax...   227   3e-58
UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Tak...   227   3e-58
UniRef50_A8WSQ7 Putative uncharacterized protein n=2 Tax=Caenorh...   226   5e-58
UniRef50_UPI0000ECD739 Cytoplasmic tyrosine-protein kinase BMX (...   225   1e-57
UniRef50_Q9XW34 Protein Y69E1A.3, partially confirmed by transcr...   223   4e-57
UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine ki...   222   1e-56
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   221   2e-56
UniRef50_O44570 Putative uncharacterized protein n=1 Tax=Caenorh...   221   2e-56
UniRef50_Q9U3B5 Protein K09B11.5a, confirmed by transcript evide...   221   2e-56
UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine ki...   220   4e-56
UniRef50_Q23102 Protein W01B6.5, partially confirmed by transcri...   220   4e-56
UniRef50_Q21299 Protein W08D2.8, partially confirmed by transcri...   220   4e-56
UniRef50_Q19704 Protein F22B3.8, partially confirmed by transcri...   219   7e-56
UniRef50_A8P3F9 Protein kinase domain containing protein n=1 Tax...   218   1e-55
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...   218   2e-55
UniRef50_B3XVX8 Protein tyrosine kinase fes/fps n=1 Tax=Codonosi...   217   2e-55
UniRef50_C4Q0E9 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   217   3e-55
UniRef50_Q21292 Protein K07F5.4a, partially confirmed by transcr...   213   7e-54
UniRef50_B4DSE0 Ephrin receptor n=19 Tax=Euteleostomi RepID=B4DS...   212   9e-54
UniRef50_B3XVX1 Protein tyrosine kinase syk (Fragment) n=1 Tax=M...   211   3e-53
UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n...   210   3e-53
UniRef50_Q4RVA1 Chromosome 15 SCAF14992, whole genome shotgun se...   209   9e-53
UniRef50_UPI00005A03D8 PREDICTED: similar to Ephrin type-A recep...   208   2e-52
UniRef50_UPI000194BA20 PREDICTED: EPH receptor A3 n=2 Tax=Eutele...   207   3e-52
UniRef50_Q4SQX3 Chromosome 11 SCAF14528, whole genome shotgun se...   206   8e-52
UniRef50_A8XT57 Putative uncharacterized protein n=1 Tax=Caenorh...   206   8e-52
UniRef50_Q6PFV6 Ephrin receptor n=8 Tax=Amniota RepID=Q6PFV6_MOUSE    205   1e-51
UniRef50_P29323 Ephrin type-B receptor 2 n=364 Tax=Eumetazoa Rep...   204   2e-51
UniRef50_Q07497 Ephrin type-B receptor 5 n=68 Tax=Euteleostomi R...   204   3e-51
UniRef50_A8XI09 Putative uncharacterized protein n=1 Tax=Caenorh...   204   3e-51
UniRef50_UPI0001757DA5 PREDICTED: similar to insulin receptor, p...   204   3e-51
UniRef50_Q4T272 Chromosome undetermined SCAF10323, whole genome ...   203   4e-51
UniRef50_P54756 Ephrin type-A receptor 5 n=102 Tax=Euteleostomi ...   203   5e-51
UniRef50_Q4RV12 Ephrin receptor (Fragment) n=3 Tax=Euteleostomi ...   203   6e-51
UniRef50_Q9Y1Y3 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   201   2e-50
UniRef50_P29317 Ephrin type-A receptor 2 n=31 Tax=Euteleostomi R...   201   2e-50
UniRef50_C4PYF4 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   201   2e-50
UniRef50_UPI0000E47549 PREDICTED: similar to Cek8 n=2 Tax=Strong...   199   6e-50
UniRef50_Q8I4A8 Protein ZK20.2, partially confirmed by transcrip...   199   8e-50
UniRef50_B7QJ81 Eph receptor tyrosine kinase, putative n=1 Tax=I...   199   9e-50
UniRef50_Q4SUM3 Ephrin receptor (Fragment) n=5 Tax=Tetraodontida...   199   1e-49
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...   198   1e-49
UniRef50_Q4SP88 Ephrin receptor (Fragment) n=4 Tax=Euteleostomi ...   198   1e-49
UniRef50_UPI0000DB7426 PREDICTED: similar to insulin-like growth...   198   2e-49
UniRef50_UPI000180C9B0 PREDICTED: ephrin receptor gamma n=1 Tax=...   197   3e-49
UniRef50_Q4H3M7 Ephrin receptor n=3 Tax=Ciona RepID=Q4H3M7_CIOIN      197   3e-49
UniRef50_Q5D184 Ephrin receptor n=5 Tax=Neoptera RepID=Q5D184_APIME   195   1e-48
UniRef50_C4XV89 Venus kinase receptor (Fragment) n=2 Tax=Pedicul...   195   2e-48
UniRef50_Q4H3M4 Ephrin receptor n=1 Tax=Ciona intestinalis RepID...   194   2e-48
UniRef50_Q9V4E5 Eph receptor tyrosine kinase, isoform C n=25 Tax...   194   2e-48
UniRef50_C4XV88 Venus kinase receptor (Fragment) n=3 Tax=Coeloma...   193   4e-48
UniRef50_Q93105 Insulin-like receptor beta chain n=1 Tax=Aedes a...   193   4e-48
UniRef50_Q4SFJ9 Chromosome 7 SCAF14601, whole genome shotgun seq...   193   5e-48
UniRef50_C5H7R9 Venus kinase receptor (Fragment) n=2 Tax=Triboli...   193   5e-48
UniRef50_UPI00019252ED PREDICTED: similar to predicted protein n...   193   5e-48
UniRef50_Q25410 Putative molluscan insulin-related peptide(s) re...   193   6e-48
UniRef50_Q98TD0 Ephrin receptor n=6 Tax=Amniota RepID=Q98TD0_CHICK    193   7e-48
UniRef50_B7QM19 Tyrosine-protein kinase receptor n=2 Tax=Ixodes ...   192   9e-48
UniRef50_C4XV92 Venus kinase receptor (Fragment) n=6 Tax=Drosoph...   192   1e-47
UniRef50_Q05397 Focal adhesion kinase 1 n=105 Tax=cellular organ...   191   2e-47
UniRef50_B2WR86 Fibroblast growth factor receptor A n=3 Tax=Nema...   191   3e-47
UniRef50_UPI0000DB6DD4 PREDICTED: similar to Insulin-like growth...   190   3e-47
UniRef50_B7Q0S4 Tyrosine-protein kinase receptor n=1 Tax=Ixodes ...   190   3e-47
UniRef50_UPI00017923B4 PREDICTED: similar to insulin receptor n=...   190   4e-47
UniRef50_Q7Q0F6 Tyrosine-protein kinase receptor n=1 Tax=Anophel...   190   5e-47
UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rer...   190   5e-47
UniRef50_Q17JW1 Tyrosine protein kinase n=2 Tax=Culicini RepID=Q...   189   6e-47
UniRef50_UPI000186E0DC Insulin receptor precursor, putative n=2 ...   189   7e-47
UniRef50_P00529 Tyrosine-protein kinase transforming protein ros...   189   7e-47
UniRef50_C5H7S1 Venus kinase receptor n=3 Tax=Culicidae RepID=C5...   189   8e-47
UniRef50_Q8IXC7 Isoform of FGFR2 n=10 Tax=Euteleostomi RepID=Q8I...   189   9e-47
UniRef50_P21802 Fibroblast growth factor receptor 2 n=316 Tax=Eu...   189   9e-47
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...   189   1e-46
UniRef50_B4JPQ9 GH13351 n=3 Tax=Drosophila RepID=B4JPQ9_DROGR         189   1e-46
UniRef50_Q16620 BDNF/NT-3 growth factors receptor n=90 Tax=Eutel...   189   1e-46
UniRef50_Q2EKC1 Fibroblast growth factor receptor n=3 Tax=Eumeta...   188   1e-46
UniRef50_UPI0001925F5B PREDICTED: similar to ephrin receptor Eph...   188   1e-46
UniRef50_Q9U5A8 Tyrosine-protein kinase receptor n=4 Tax=Coeloma...   188   1e-46
UniRef50_C5H7S0 Venus kinase receptor (Fragment) n=2 Tax=Apis me...   188   1e-46
UniRef50_C4QEV8 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   188   1e-46
UniRef50_UPI0001792C07 PREDICTED: similar to tyrosine-protein ki...   188   2e-46
UniRef50_P08922 Proto-oncogene tyrosine-protein kinase ROS n=24 ...   188   2e-46
UniRef50_UPI000155484B PREDICTED: similar to type 1 IGF receptor...   187   3e-46
UniRef50_Q7KJ08 Alk n=7 Tax=melanogaster group RepID=Q7KJ08_DROME     187   3e-46
UniRef50_UPI0001926939 PREDICTED: similar to eph receptor A7 n=4...   187   3e-46
UniRef50_UPI000186EE87 tyrosine kinase receptor, putative n=4 Ta...   187   3e-46
UniRef50_P06213 Insulin receptor subunit beta n=70 Tax=Euteleost...   187   3e-46
UniRef50_UPI000175802D PREDICTED: similar to leukocyte receptor ...   187   4e-46
UniRef50_B7P3J2 Leukocyte tyrosine kinase receptor, putative n=1...   187   4e-46
UniRef50_Q0P4R9 Discoidin domain receptor family, member 2 n=5 T...   187   4e-46
UniRef50_P08069 Insulin-like growth factor 1 receptor beta chain...   187   4e-46
UniRef50_B4LZ52 GJ23294 n=4 Tax=Coelomata RepID=B4LZ52_DROVI          187   4e-46
UniRef50_Q52V39 Tyrosine-protein kinase receptor n=3 Tax=Branchi...   187   4e-46
UniRef50_Q9U2T8 Protein Y116A8C.38, partially confirmed by trans...   186   5e-46
UniRef50_Q28WN9 GA20930 n=6 Tax=Drosophila RepID=Q28WN9_DROPS         186   5e-46
UniRef50_Q8JG38 Fibroblast growth factor receptor 2 n=25 Tax=Eut...   186   5e-46
UniRef50_B0XJJ2 Testis-specific serine/threonine-protein kinase ...   186   6e-46
UniRef50_Q05688 Insulin-like growth factor 1 receptor beta chain...   186   6e-46
UniRef50_P34152 Focal adhesion kinase 1 n=16 Tax=Eutheria RepID=...   186   6e-46
UniRef50_B3RWF6 Putative uncharacterized protein (Fragment) n=1 ...   186   6e-46
UniRef50_B2WR85 Fibroblast growth factor receptor B n=4 Tax=Nema...   186   8e-46
UniRef50_C9DED1 Fibroblast growth factor receptor B n=1 Tax=Sacc...   186   1e-45
UniRef50_Q170Z1 Tyrosine-protein kinase receptor (Fragment) n=1 ...   185   1e-45
UniRef50_P14616 Insulin receptor-related protein beta chain n=11...   185   1e-45
UniRef50_Q03351 NT-3 growth factor receptor n=21 Tax=Euteleostom...   185   1e-45
UniRef50_UPI0000EC9DFD Insulin receptor related tyrosine kinase ...   185   1e-45
UniRef50_B8JIA2 Fibroblast growth factor receptor 3 (Fragment) n...   185   2e-45
UniRef50_Q59FL9 Fibroblast growth factor receptor 3 isoform 1 va...   185   2e-45
UniRef50_A3KPS2 Tyrosine-protein kinase receptor (Fragment) n=11...   185   2e-45
UniRef50_UPI000180B27C PREDICTED: similar to proto-oncogene c-ro...   184   2e-45
UniRef50_UPI000180BC98 PREDICTED: similar to V-yes-1 Yamaguchi s...   184   2e-45
UniRef50_UPI000186EA5D proto-oncogene receptor tyrosine protein ...   184   3e-45
UniRef50_Q16288 NT-3 growth factor receptor n=57 Tax=Euteleostom...   184   3e-45
UniRef50_Q4SMF1 Chromosome 8 SCAF14552, whole genome shotgun seq...   184   3e-45
UniRef50_A9RMB5 Predicted protein n=12 Tax=Viridiplantae RepID=A...   184   3e-45
UniRef50_UPI000186E417 tyrosine-protein kinase transmembrane rec...   184   4e-45
UniRef50_Q7QIP0 AGAP006988-PA n=5 Tax=Endopterygota RepID=Q7QIP0...   183   4e-45
UniRef50_A8WVF6 Putative uncharacterized protein n=2 Tax=root Re...   183   5e-45
UniRef50_Q16832 Discoidin domain-containing receptor 2 n=50 Tax=...   183   5e-45
UniRef50_C3XPN4 Putative uncharacterized protein n=1 Tax=Branchi...   183   6e-45
UniRef50_C3Y1A6 Putative uncharacterized protein (Fragment) n=1 ...   183   6e-45
UniRef50_Q4RM64 Chromosome 10 SCAF15019, whole genome shotgun se...   183   7e-45
UniRef50_B3RT16 Tyrosine-protein kinase receptor (Fragment) n=1 ...   183   8e-45
UniRef50_Q2LC18 Tyrosine-protein kinase receptor (Fragment) n=2 ...   182   1e-44
UniRef50_C9DED0 Fibroblast growth factor receptor A n=2 Tax=Sacc...   182   1e-44

Sequences not found previously or not previously below threshold:

UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni ...   226   7e-58
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...   213   4e-54
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...   206   7e-52
UniRef50_Q9N3S5 Putative uncharacterized protein n=4 Tax=Caenorh...   206   9e-52
UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   200   3e-50
UniRef50_P42687 Tyrosine-protein kinase SPK-1 n=1 Tax=Girardia t...   196   4e-49
UniRef50_Q4S6E0 Chromosome 10 SCAF14728, whole genome shotgun se...   188   2e-46
UniRef50_B4DP99 cDNA FLJ51496, highly similar to Tyrosine-protei...   187   4e-46
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...   185   1e-45
UniRef50_UPI00017B4565 UPI00017B4565 related cluster n=1 Tax=Tet...   184   3e-45
UniRef50_UPI0001A2C9CC UPI0001A2C9CC related cluster n=1 Tax=Dan...   184   3e-45
UniRef50_C4Q5Z3 Ephrin receptor, putative n=1 Tax=Schistosoma ma...   183   4e-45
UniRef50_P07949 Proto-oncogene tyrosine-protein kinase receptor ...   183   6e-45
UniRef50_Q4RXA0 Chromosome 11 SCAF14979, whole genome shotgun se...   183   7e-45
UniRef50_Q4S1S8 Chromosome undetermined SCAF14764, whole genome ...   183   8e-45

>UniRef50_Q18865 Putative uncharacterized protein n=6 Tax=Caenorhabditis
           RepID=Q18865_CAEEL
          Length = 431

 Score =  397 bits (1022), Expect = e-109,   Method: Composition-based stats.
 Identities = 257/261 (98%), Positives = 258/261 (98%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEK TSANH
Sbjct: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKNTSANH 60

Query: 61  FVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           FVVRE+DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVK VLK AVERQKWELYHED
Sbjct: 61  FVVREADHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKVVLKHAVERQKWELYHED 120

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN
Sbjct: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIH 240
           LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIH
Sbjct: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIH 240

Query: 241 EKNLMHRDVAARNCLYGGGQV 261
           EKNLMHRDVAARNCLYGGGQV
Sbjct: 241 EKNLMHRDVAARNCLYGGGQV 261


>UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorhabditis briggsae
           RepID=A8XFT2_CAEBR
          Length = 577

 Score =  330 bits (848), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 155/266 (58%), Positives = 194/266 (72%), Gaps = 13/266 (4%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKK---TS 57
           M DKD+  + +YHGLLPREDI+ ML K G FL+R++EP +GE RQ+VLS +  ++     
Sbjct: 1   MFDKDIHTEPWYHGLLPREDIKAMLRKTGDFLIRSTEPKQGEARQYVLSAMQNEELEDAG 60

Query: 58  ANHFVVR-ESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL 116
             H+V+R  ++++++++  GF TI  LVN+Y++TK+           VLK  + +Q WE+
Sbjct: 61  VKHYVMRVNANNQIFLETKGFETITSLVNYYMTTKDPIKK-----MTVLKTPIVKQDWEI 115

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
            H  VELTKKLGEGAFGEVWKG   KI   N +    A+KTAKLES+ KEQIKEIMREAR
Sbjct: 116 EHSQVELTKKLGEGAFGEVWKG---KITMKNGKVEDCAIKTAKLESLNKEQIKEIMREAR 172

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANG 235
           LMRNLDH NVVKFFGV AG EPLYVIMELAD GALDS L K  + P  KK E+IYQAA G
Sbjct: 173 LMRNLDHPNVVKFFGVGAGQEPLYVIMELADCGALDSYLQKNTNLPPAKKMEMIYQAACG 232

Query: 236 LAYIHEKNLMHRDVAARNCLYGGGQV 261
           + Y+HE+ L+HRD+AARNCLYGGGQV
Sbjct: 233 IGYMHERKLLHRDIAARNCLYGGGQV 258


>UniRef50_Q18684 Protein T13H10.1, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q18684_CAEEL
          Length = 533

 Score =  315 bits (809), Expect = 6e-85,   Method: Composition-based stats.
 Identities = 131/261 (50%), Positives = 174/261 (66%), Gaps = 9/261 (3%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           ++ L  + +YHGLLPRED++++L + G FL+R ++P  GE R+FVLSV         H+V
Sbjct: 8   EQVLAKEPWYHGLLPREDMKQLLTQRGDFLVRFTDPKVGEPRKFVLSVYVGVIEDIRHYV 67

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           +RE ++K  VDK  F +I +L+N+Y  +KE  +   G  + V+ + + R+ WE  H DV 
Sbjct: 68  IREHNNKFAVDKKWFSSIADLLNYYHRSKEPVA---GGPETVIIRPIGREPWEKQHSDVT 124

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L KKLGEGAFGEV  G+    +   +     A+K AKLES+TKEQIKEIM EARLMR   
Sbjct: 125 LIKKLGEGAFGEVQLGE----IRIGNTVKKAAIKLAKLESLTKEQIKEIMHEARLMRKFK 180

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIH 240
           H NVV F+GVAAG EPL VIMELAD GALDS L K     P+ KK+ ++ QA  GL Y+H
Sbjct: 181 HPNVVTFYGVAAGQEPLMVIMELADNGALDSYLKKNIGSLPISKKHTMVLQAGLGLEYLH 240

Query: 241 EKNLMHRDVAARNCLYGGGQV 261
              ++HRD+A+RNCLYG GQV
Sbjct: 241 SLQIIHRDIASRNCLYGNGQV 261


>UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA
          Length = 1315

 Score =  311 bits (798), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 91/264 (34%), Positives = 155/264 (58%), Gaps = 17/264 (6%)

Query: 2    TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
            T++ L  ++++HG+LPRE++  +L   G FL+R  E  + ++ Q VLSV         HF
Sbjct: 942  TNRPLHEEEWFHGVLPREEVVRLLRNEGDFLVR--ETTRNDESQTVLSVCWNG---HKHF 996

Query: 62   VVRESDHKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
            +V+ +    Y  +   FP+I EL+ H   ++   + + G   AVL++ V R++WEL ++D
Sbjct: 997  IVQTTAEGHYRFEGPAFPSIQELIVHQYQSELPVTGRSG---AVLRKPVLRERWELSNDD 1053

Query: 121  VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
            V L  K+G G FG+V+K KL      + +  LVAVKT ++ ++ +EQ ++ ++E R+++ 
Sbjct: 1054 VILLDKIGRGNFGDVYKAKLK-----SSKNTLVAVKTCRM-TLPEEQKRKFLQEGRILKQ 1107

Query: 181  LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK--YELIYQAANGLAY 238
             DH N+VK  G+    +P+ ++MEL  GG+L   L K    + ++    +   AA G+ Y
Sbjct: 1108 YDHPNIVKLIGICVQKQPIMIVMELVAGGSLLMFLRKNASTLGQRQMMGMCRDAAAGMRY 1167

Query: 239  IHEKNLMHRDVAARNCLYGGGQVL 262
            +  KN +HRD+AARNCL G   ++
Sbjct: 1168 LESKNCIHRDLAARNCLIGSENIV 1191


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score =  311 bits (797), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 99/265 (37%), Positives = 149/265 (56%), Gaps = 19/265 (7%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           +++K L  Q +YHG +PR + QE+L K G FL+R S    GE   +VLSV  + +    H
Sbjct: 450 ISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGE---YVLSVYSDGQ--RRH 504

Query: 61  FVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-WELYHE 119
           F+++  D+    +  GF  I +L++H+ +TK+  + K G    VL   + + K W L HE
Sbjct: 505 FIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSG---VVLLNPIPKDKKWILSHE 561

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           DV L + LG+G FGEV+KG L            VAVKT K E + +E   + ++EA++++
Sbjct: 562 DVILGELLGKGNFGEVYKGTL-------KDKTSVAVKTCK-EDLPQELKIKFLQEAKILK 613

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLA 237
             DH N+VK  GV    +P+Y+IMEL  GG   + L +      + +  +    AA G+ 
Sbjct: 614 QYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGML 673

Query: 238 YIHEKNLMHRDVAARNCLYGGGQVL 262
           Y+  KN +HRD+AARNCL G   VL
Sbjct: 674 YLESKNCIHRDLAARNCLVGENNVL 698


>UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateria RepID=FPS_DROME
          Length = 1325

 Score =  303 bits (776), Expect = 5e-81,   Method: Composition-based stats.
 Identities = 88/259 (33%), Positives = 150/259 (57%), Gaps = 18/259 (6%)

Query: 2    TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
            T++ L  ++++HG+LPRE++  +LN  G FL+R  E ++ E+ Q VLSV         HF
Sbjct: 951  TNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVR--ETIRNEESQIVLSVCWNG---HKHF 1005

Query: 62   VVRESD-HKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
            +V+ +       +   F +I EL+ H   ++   + K G   A+L++ V R++WEL ++D
Sbjct: 1006 IVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSG---AILRRPVCRERWELSNDD 1062

Query: 121  VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
            V L +++G G FG+V+K KL          + VAVKT ++ ++  EQ ++ ++E R+++ 
Sbjct: 1063 VVLLERIGRGNFGDVYKAKLKST------KLDVAVKTCRM-TLPDEQKRKFLQEGRILKQ 1115

Query: 181  LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAY 238
             DH N+VK  G+    +P+ ++MEL  GG+L + L K        ++  +   AA G+ Y
Sbjct: 1116 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRY 1175

Query: 239  IHEKNLMHRDVAARNCLYG 257
            +  KN +HRD+AARNCL  
Sbjct: 1176 LESKNCIHRDLAARNCLVD 1194


>UniRef50_P34265 Probable tyrosine-protein kinase kin-31 n=4 Tax=Caenorhabditis
           RepID=KIN31_CAEEL
          Length = 437

 Score =  302 bits (773), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 111/264 (42%), Positives = 164/264 (62%), Gaps = 13/264 (4%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKK----TSAN 59
             +  + Y+HGL+ RED+ ++L+  G +++R S+P  GE R ++LSV+   K    +S  
Sbjct: 13  PTIEKEAYFHGLIQREDVFQLLDNNGDYVVRLSDPKPGEPRSYILSVMFNNKLDENSSVK 72

Query: 60  HFVVRESDHKVYVDKI-GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
           HFV+   ++K +V+    F TI ++++HY  ++             +   V RQ WEL H
Sbjct: 73  HFVINSVENKYFVNNNMSFNTIQQMLSHYQKSRTEI-----LEACKILHPVRRQFWELDH 127

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
            ++ + KKLGEGAFGEV  G +        + V VAVK  K + + K+QIK+ + EAR M
Sbjct: 128 GNIVIEKKLGEGAFGEVSSGVMK--FKRGGRLVKVAVKQVKTDGIGKDQIKDFLMEARTM 185

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-FPMIKKYELIYQAANGLA 237
           RNL H N+V+F G+A   EPL+++MELA GGALDS L      P+ K++E++ QAA GL 
Sbjct: 186 RNLGHPNIVRFLGIAVLQEPLFLVMELATGGALDSYLKHNELLPIDKRHEMLLQAAWGLE 245

Query: 238 YIHEKNLMHRDVAARNCLYGGGQV 261
           YIH K ++HRD+AARNCLYG G+V
Sbjct: 246 YIHGKPMLHRDIAARNCLYGDGKV 269


>UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, partial n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793081
          Length = 770

 Score =  302 bits (773), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 87/256 (33%), Positives = 148/256 (57%), Gaps = 18/256 (7%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           K L+ ++++HG+LPRE++  +L K G FL+R  E  + ++ Q VLSV         HF+V
Sbjct: 530 KSLIEEEWFHGVLPREEVVRLLTKEGDFLVR--ETTRNDENQTVLSVCWGG---HKHFIV 584

Query: 64  RES-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           + + + +   +   FPTI EL+ +   +    +++ G   A+L+Q + R++WEL ++DV 
Sbjct: 585 QTTSEGEFRFEGPSFPTIQELITYQYQSALPVTSRSG---AILRQPIPRERWELNNDDVL 641

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L +K+G G FG+V+K +L             AVKT ++ ++  E  K+ ++E R+++  D
Sbjct: 642 LLEKIGRGNFGDVYKARLRSTNK------EAAVKTCRV-TVPDEHKKKFLQEGRILKQYD 694

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIH 240
           H NVVK  G+    +P+ ++MEL  GG+L S L        +++   +   AA G+ Y+ 
Sbjct: 695 HPNVVKLIGICVQKQPIMIVMELVAGGSLLSYLRNNSKTLSVLQLVSMCRDAAAGMMYLE 754

Query: 241 EKNLMHRDVAARNCLY 256
            KN +HRD+AARNCL 
Sbjct: 755 SKNCIHRDLAARNCLV 770


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  301 bits (771), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 78/272 (28%), Positives = 129/272 (47%), Gaps = 27/272 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G+     LS+    +    H+
Sbjct: 166 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQ-----LSISLRYEGRVYHY 220

Query: 62  VVRES-DHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA------VERQK 113
            +  + D KVYV  +  F T+ ELV+H+ +  +   T          +           K
Sbjct: 221 RINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK 280

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV+ G   K        + VAVKT K ++M   +++E ++
Sbjct: 281 WEMERTDITMKHKLGGGQYGEVYVGVWKKY------SLTVAVKTLKEDTM---EVEEFLK 331

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK---KYELIY 230
           EA +M+ + H N+V+  GV     P Y++ E    G L   L + +   +       +  
Sbjct: 332 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 391

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q ++ + Y+ +KN +HRD+AARNCL G   V+
Sbjct: 392 QISSAMEYLEKKNFIHRDLAARNCLVGENHVV 423


>UniRef50_Q20933 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q20933_CAEEL
          Length = 444

 Score =  300 bits (769), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 130/259 (50%), Positives = 165/259 (63%), Gaps = 12/259 (4%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVV-GEKKTSANHFV 62
            ++  Q ++HGLLPRE+++ +L K G +L+RTSEP  G+ R  ++SV+  E      H+V
Sbjct: 1   MEINEQPFFHGLLPREEVKLLLQKNGDYLMRTSEPQ-GQARHLIISVMQNETSQEVAHYV 59

Query: 63  VRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDV 121
           +R SD    + DKI F T+ ELVNH+   K S    +    +VL   + RQ WEL H D+
Sbjct: 60  IRTSDGAYSITDKIKFGTLTELVNHHKQAKIS----EEVASSVLVNPIGRQSWELNHADI 115

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
            +TK LGEGAFGEV  G L          V VA+K AKLE +TKEQIKEI+ EARLMR  
Sbjct: 116 TMTKVLGEGAFGEVKLGTLK----MGSTTVDVAIKVAKLEKVTKEQIKEIITEARLMRGF 171

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIH 240
           DH NVVK +GVAA  EPL V+MEL  GGALD  L K       +K ++I Q A GLAYIH
Sbjct: 172 DHKNVVKCYGVAAIDEPLLVVMELVPGGALDKYLQKNSSVQWPEKLDIIAQVAAGLAYIH 231

Query: 241 EKNLMHRDVAARNCLYGGG 259
            KN++HRD+AARN LYG G
Sbjct: 232 SKNIIHRDIAARNILYGKG 250


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  300 bits (768), Expect = 4e-80,   Method: Composition-based stats.
 Identities = 80/274 (29%), Positives = 129/274 (47%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+         H+
Sbjct: 190 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYDGRVYHY 244

Query: 62  VVRE-SDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ--------AVER 111
            + E SD KVYV  +  F T+ ELV+H+    E        +    KQ        + E 
Sbjct: 245 RISEDSDGKVYVTAEAKFNTLAELVHHHSVLHEGHGLITPLLYPAPKQNKPTVFPLSPEP 304

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ 
Sbjct: 305 DEWEICRTDIVMKHKLGGGQYGEVYEAVWKRYGNT------VAVKTLKEDTM---ALKDF 355

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYEL 228
           + EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +
Sbjct: 356 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYM 415

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+  +N +HRD+AARNCL G   ++
Sbjct: 416 ATQIASGMSYLESRNFIHRDLAARNCLVGDNNLV 449


>UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=4 Tax=Endopterygota
           RepID=P18106-3
          Length = 475

 Score =  299 bits (767), Expect = 5e-80,   Method: Composition-based stats.
 Identities = 88/259 (33%), Positives = 150/259 (57%), Gaps = 18/259 (6%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           T++ L  ++++HG+LPRE++  +LN  G FL+R  E ++ E+ Q VLSV         HF
Sbjct: 101 TNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVR--ETIRNEESQIVLSVCWNG---HKHF 155

Query: 62  VVRESD-HKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           +V+ +       +   F +I EL+ H   ++   + K G   A+L++ V R++WEL ++D
Sbjct: 156 IVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSG---AILRRPVCRERWELSNDD 212

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V L +++G G FG+V+K KL          + VAVKT ++ ++  EQ ++ ++E R+++ 
Sbjct: 213 VVLLERIGRGNFGDVYKAKLKST------KLDVAVKTCRM-TLPDEQKRKFLQEGRILKQ 265

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAY 238
            DH N+VK  G+    +P+ ++MEL  GG+L + L K        ++  +   AA G+ Y
Sbjct: 266 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRY 325

Query: 239 IHEKNLMHRDVAARNCLYG 257
           +  KN +HRD+AARNCL  
Sbjct: 326 LESKNCIHRDLAARNCLVD 344


>UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria RepID=Q2VXS8_HUMAN
          Length = 764

 Score =  299 bits (767), Expect = 6e-80,   Method: Composition-based stats.
 Identities = 90/261 (34%), Positives = 149/261 (57%), Gaps = 18/261 (6%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           K L  Q +YHG +PR ++ E+L   G FL+R S+     K+++VLSV+ +      HF++
Sbjct: 395 KPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ----GKQEYVLSVLWDGLP--RHFII 448

Query: 64  RESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
           +  D+   ++  GFP+I  L++H +ST++  + K G    VL +AV + KW L HED+ L
Sbjct: 449 QSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSG---VVLHRAVPKDKWVLNHEDLVL 505

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
            +++G G FGEV+ G+L           LVAVK+ + E++  +   + ++EAR+++   H
Sbjct: 506 GEQIGRGNFGEVFSGRLRA------DNTLVAVKSCR-ETLPPDLKAKFLQEARILKQYSH 558

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHE 241
            N+V+  GV    +P+Y++MEL  GG   + L        +    +++  AA G+ Y+  
Sbjct: 559 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 618

Query: 242 KNLMHRDVAARNCLYGGGQVL 262
           K  +HRD+AARNCL     VL
Sbjct: 619 KCCIHRDLAARNCLVTEKNVL 639


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  299 bits (766), Expect = 7e-80,   Method: Composition-based stats.
 Identities = 84/275 (30%), Positives = 136/275 (49%), Gaps = 31/275 (11%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
           D+ L  + ++ G + R D ++ L    NK G FL+R SE  KGE   F LSV+       
Sbjct: 108 DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGE---FSLSVL--DGAVV 162

Query: 59  NHFVVRESD-HKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ---- 112
            H+ ++  D    ++ +   F T+ E V+HY  T +    K G     ++          
Sbjct: 163 KHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYK 222

Query: 113 ---KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
              +WE+    ++L K+LG G FGEVW+G         +    VAVKT K  SM      
Sbjct: 223 TVDQWEIDRNSIQLLKRLGSGQFGEVWEGLW-------NNTTPVAVKTLKPGSMDPN--- 272

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKY 226
           + +REA++M+NL H  +++ + V    +P+Y+I EL   G+L   L         + ++ 
Sbjct: 273 DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQV 332

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
           ++  Q A+G+AY+  +N +HRD+AARN L G   +
Sbjct: 333 DMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNI 367


>UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax=Brugia malayi
           RepID=A8P4D4_BRUMA
          Length = 428

 Score =  297 bits (761), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 110/266 (41%), Positives = 159/266 (59%), Gaps = 9/266 (3%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA-N 59
           M   +L  + YYHGLLPRED+  +L   G FL+R+SE    + RQ ++S++ EK+ +   
Sbjct: 1   MGGGNLEDENYYHGLLPREDLPHLLINEGDFLVRSSETAPNQPRQVIISILVEKRGAILR 60

Query: 60  HFVVRESDHKVYVD--KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
           H VV+++ +  YV   +  F ++ EL+  Y    E         KAVLK+A+ R  WEL 
Sbjct: 61  HIVVQQNAYGKYVTDARASFDSVPELIQFYQKCGEPVL--STVPKAVLKRAITRPPWELR 118

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
           HE V +  K+GEG FGEV+ GK         + + VA+K AK    +KE+IKE+M+EARL
Sbjct: 119 HETVIIENKIGEGEFGEVFSGKYKL---PTGRVIEVAIKLAKTAETSKEKIKEMMKEARL 175

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYE-LIYQAANGL 236
           MRN +H NV++ +GV    +PL ++MEL DGGALD  L K    +  K E ++   A G+
Sbjct: 176 MRNYEHPNVIRMYGVCVEHDPLLIVMELVDGGALDDFLKKNRVSVKDKVEKMVAGGAWGV 235

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQVL 262
            Y+H KN +HRD+AARNCL     ++
Sbjct: 236 EYLHSKNCIHRDIAARNCLLTRTGII 261


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  295 bits (757), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 75/273 (27%), Positives = 128/273 (46%), Gaps = 28/273 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 167 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 221

Query: 62  VVRE--SDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA------VERQ 112
            + E  SD KVYV  +  F T+ ELV+H+    +   T+         +        E  
Sbjct: 222 RINEDTSDGKVYVTTESRFNTLAELVHHHSMHSDGLITQLLYPAPKHNKPTVFALSPEPD 281

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WE+   D+ +  KLG G +G+V++    +        + VAVKT K ++M    +K+ +
Sbjct: 282 EWEINRTDIVMRHKLGGGQYGDVYEAVWKRYN------MTVAVKTLKEDTM---ALKDFL 332

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELI 229
            EA +M+ + H N+V+  GV     P Y+I E    G L   L    + +   +    + 
Sbjct: 333 EEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMSKGNLLDYLRQGNRENINAVVLMYMA 392

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            Q A+ ++Y+  +  +HRD+AARNCL G   ++
Sbjct: 393 TQIASAMSYLESRMFIHRDLAARNCLVGENHLV 425


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  295 bits (757), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 77/272 (28%), Positives = 130/272 (47%), Gaps = 27/272 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 120 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 174

Query: 62  VVRE-SDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA------VERQK 113
            +   SD K+YV  +  F T+ ELV+H+ +  +   T          +           K
Sbjct: 175 RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK 234

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++G   K        + VAVKT K ++M   +++E ++
Sbjct: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKY------SLTVAVKTLKEDTM---EVEEFLK 285

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK---KYELIY 230
           EA +M+ + H N+V+  GV     P Y+I E    G L   L + +   +       +  
Sbjct: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q ++ + Y+ +KN +HRD+AARNCL G   ++
Sbjct: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLV 377


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  295 bits (757), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 78/274 (28%), Positives = 130/274 (47%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 255 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 309

Query: 62  VVRES-DHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ--------AVER 111
            + E  D KV+V  +  F T+ ELV+H+    E        +    KQ        + E 
Sbjct: 310 RISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEP 369

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ 
Sbjct: 370 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT------VAVKTLKEDTM---ALKDF 420

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYEL 228
           + EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +
Sbjct: 421 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYM 480

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+  +N +HRD+AARNCL G  +++
Sbjct: 481 ATQIASGMSYLESRNYIHRDLAARNCLVGDNKLV 514


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  295 bits (757), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 78/274 (28%), Positives = 130/274 (47%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 246 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 300

Query: 62  VVRES-DHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ--------AVER 111
            + E  D KV+V  +  F T+ ELV+H+    E        +    KQ        + E 
Sbjct: 301 RISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEP 360

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ 
Sbjct: 361 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT------VAVKTLKEDTM---ALKDF 411

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYEL 228
           + EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +
Sbjct: 412 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYM 471

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+  +N +HRD+AARNCL G  +++
Sbjct: 472 ATQIASGMSYLESRNYIHRDLAARNCLVGDNKLV 505


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  295 bits (757), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 78/274 (28%), Positives = 130/274 (47%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 247 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 301

Query: 62  VVRES-DHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ--------AVER 111
            + E  D KV+V  +  F T+ ELV+H+    E        +    KQ        + E 
Sbjct: 302 RISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEP 361

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ 
Sbjct: 362 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT------VAVKTLKEDTM---ALKDF 412

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYEL 228
           + EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +
Sbjct: 413 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYM 472

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+  +N +HRD+AARNCL G  +++
Sbjct: 473 ATQIASGMSYLESRNYIHRDLAARNCLVGDNKLV 506


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score =  295 bits (756), Expect = 9e-79,   Method: Composition-based stats.
 Identities = 77/272 (28%), Positives = 130/272 (47%), Gaps = 27/272 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 6   NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 60

Query: 62  VVRE-SDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA------VERQK 113
            +   SD K+YV  +  F T+ ELV+H+ +  +   T          +           K
Sbjct: 61  RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK 120

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++G   K        + VAVKT K ++M   +++E ++
Sbjct: 121 WEMERTDITMKHKLGGGQYGEVYEGVWKKY------SLTVAVKTLKEDTM---EVEEFLK 171

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK---KYELIY 230
           EA +M+ + H N+V+  GV     P Y+I E    G L   L + +   +       +  
Sbjct: 172 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMAT 231

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q ++ + Y+ +KN +HRD+AARNCL G   ++
Sbjct: 232 QISSAMEYLEKKNFIHRDLAARNCLVGENHLV 263


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score =  292 bits (748), Expect = 8e-78,   Method: Composition-based stats.
 Identities = 80/272 (29%), Positives = 130/272 (47%), Gaps = 27/272 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G +     S+         H+
Sbjct: 180 NSLEKHSWYHGPISRNAAEYLLSSGIDGSFLVRDSESSPGHR-----SISLRFDGRVYHY 234

Query: 62  VVRE-SDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER------QK 113
            +   SD KV+V  +  F TI ELV+H+    +   T      A +++ +         +
Sbjct: 235 RISSGSDGKVFVTTESKFSTIAELVHHHCKQSDGLITTLRYPAAKMQKPIIYGVSPLPDE 294

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++    K         +VAVKT + E+M   ++ E +R
Sbjct: 295 WEIERTDISMKNKLGGGQYGEVYEAIWKKHNK------IVAVKTLREENM---RVDEFLR 345

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIY 230
           EA +M+N+ H N+V+  GV     P Y++ E    G L   L    +   P +    +  
Sbjct: 346 EAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYGNLLEYLRDNDETSLPAVTLLYMAT 405

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q A G++Y+ + + +HRD+AARNCL G   +L
Sbjct: 406 QVAFGMSYLEKNSFIHRDLAARNCLLGEHHLL 437


>UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7PSP3_IXOSC
          Length = 674

 Score =  292 bits (748), Expect = 9e-78,   Method: Composition-based stats.
 Identities = 87/260 (33%), Positives = 147/260 (56%), Gaps = 18/260 (6%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           L  + ++HG+LPRE++  +L   G +L+R  E ++ E++Q VLSV  +      HF+V+ 
Sbjct: 308 LQDEDWFHGVLPREEVVRLLVNNGDYLVR--ETMRNEEKQVVLSVCWQG---HKHFIVQT 362

Query: 66  S-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT 124
           + D K   +   F T+ EL+ +        ++K G   A+L+  + R++WEL ++DVEL 
Sbjct: 363 TSDGKYRFEGPAFGTVQELIVYQHHLGLPVTSKSG---AILQNPIFRERWELNNDDVELV 419

Query: 125 KKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHI 184
           +K+G G FG+V++  L        Q   VAVKT ++ ++  E  K+ ++E R+++  DH 
Sbjct: 420 EKIGRGNFGDVYRAVLHP------QRTEVAVKTCRV-NLPDEHKKKFLQEGRILKQYDHP 472

Query: 185 NVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEK 242
           N+VKF G+    +P+ ++MEL  GG+L + L          +   +    A G+AY+  K
Sbjct: 473 NIVKFIGICVQKQPIMIVMELVPGGSLLAFLRNQGPKLNPKELLNMCIDTAAGMAYLESK 532

Query: 243 NLMHRDVAARNCLYGGGQVL 262
           N +HRD+AARNCL G    +
Sbjct: 533 NCIHRDLAARNCLVGRNNTV 552


>UniRef50_A8WMP8 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8WMP8_CAEBR
          Length = 284

 Score =  292 bits (747), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 127/266 (47%), Positives = 164/266 (61%), Gaps = 19/266 (7%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN----- 59
            ++ + YYHGLLPRED   +L + G FL+R SEP  G ++ F+LS + + K+ +N     
Sbjct: 10  TIIREGYYHGLLPREDAAALLTQNGDFLIRISEPTDGAEQNFILSCMTDDKSKSNDENPG 69

Query: 60  --HFVVRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL 116
             +FVV   + +  V +   FPTI +LV  +         K+      L + + RQ WEL
Sbjct: 70  MQNFVVGFQNGRYLVAENHSFPTIEKLVEFHK--------KNRIQNIFLNRPIMRQSWEL 121

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
            HE V + KKLGEGAFGEV  G+         +PV VAVK AK E +TK QIKE MREAR
Sbjct: 122 DHETVVILKKLGEGAFGEVSMGEY--TPKMGGKPVKVAVKQAKPEKLTKVQIKEFMREAR 179

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKY-ELIYQAANG 235
           +M+NL H NVVKF+GVAA  EPLY++MELA  G+LD  L K      + Y E+I QAA G
Sbjct: 180 IMKNLSHENVVKFYGVAAVQEPLYMVMELASNGSLDGYLKKNPDLRPEVYNEMILQAAWG 239

Query: 236 LAYIHEKNLMHRDVAARNCLYGGGQV 261
           L Y HEKN++HRD+A RNCLYG  QV
Sbjct: 240 LEYCHEKNIIHRDMAVRNCLYGDRQV 265


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  290 bits (744), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 76/277 (27%), Positives = 129/277 (46%), Gaps = 33/277 (11%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           K +  + +Y   + R + ++ L    N+ G FL+R SE    +   + LSV      +  
Sbjct: 123 KSIEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHND---YSLSV--RDGDTVK 177

Query: 60  HFVVRESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE------- 110
           H+ +R+ D   +    +  F T+ ELV HY    +            +++ V        
Sbjct: 178 HYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRT 237

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
           R +WE+    ++  +KLG G FG+VW+G         +    VA+KT K  +M     K+
Sbjct: 238 RDQWEIDRTSLKFVRKLGSGQFGDVWEGLW-------NNTTPVAIKTLKSGTMDP---KD 287

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL-----GKLHFPMIKK 225
            + EA++M+ L H  +++ + V    EP+Y+I EL   G+L   L           M   
Sbjct: 288 FLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTL 347

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            ++  Q A G+AY+  +N +HRD+AARN L G G ++
Sbjct: 348 IDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIV 384


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  289 bits (740), Expect = 8e-77,   Method: Composition-based stats.
 Identities = 77/272 (28%), Positives = 127/272 (46%), Gaps = 27/272 (9%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLN----KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
           +K    +++Y G + R + ++ L       G FL+R +E   G    F LSV      S 
Sbjct: 118 EKSYEAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVG---NFSLSV--RDGDSV 172

Query: 59  NHFVVRESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ---AVERQK 113
            H+ VR+ D   Y    +  F ++ ELV HY    +             K     + +  
Sbjct: 173 KHYRVRKLDTGGYFITTRAPFNSLYELVQHYTKDADGLVCALTLPCPKDKPVTGGIAKDA 232

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+  E + L +KLG G FGEVW G         +    VAVKT K  +M+       + 
Sbjct: 233 WEIPRESLRLNRKLGAGQFGEVWAGVW-------NNTTQVAVKTLKPGTMSPAS---FLD 282

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIY 230
           EA +M+ L H ++V+ + + +  EP+Y++ E   GG+L   L K   ++  +    ++  
Sbjct: 283 EAGVMKKLRHKHLVQLYAICSDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAA 342

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q A+G+A++  +  +HRD+AARN L G   + 
Sbjct: 343 QVASGMAFLEAQGYIHRDLAARNILVGENYIC 374


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  288 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 79/271 (29%), Positives = 130/271 (47%), Gaps = 23/271 (8%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQ----FLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
             +  +++Y G + R+D + +L  PG     FL+R SE  KG     +      +  +  
Sbjct: 151 DSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVK 210

Query: 60  HFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLK---QAVERQKW 114
           H+ +R+ D+  Y    +  F T+ +LV HY    +    K  TV   +K   Q + +  W
Sbjct: 211 HYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAW 270

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+  E + L  KLG+G FGEVW G         +    VA+KT K  +M  E     ++E
Sbjct: 271 EIPRESLRLEVKLGQGCFGEVWMGTW-------NGTTKVAIKTLKPGTMMPEA---FLQE 320

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIYQ 231
           A++M+ L H  +V  + V +  EP+Y++ E    G+L   L +    +  + +  ++  Q
Sbjct: 321 AQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQ 379

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            A+G+AYI   N +HRD+ A N L G   V 
Sbjct: 380 IADGMAYIERMNYIHRDLRAANILVGENLVC 410


>UniRef50_UPI000186DA97 tyrosine-protein kinase transforming protein FPS, putative n=1
           Tax=Pediculus humanus corporis RepID=UPI000186DA97
          Length = 850

 Score =  287 bits (736), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 85/262 (32%), Positives = 150/262 (57%), Gaps = 18/262 (6%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           K L+ ++++HG+LPRE++  +L   G FL+R  E  + ++ Q VLSV         HF+V
Sbjct: 479 KALIDEEWFHGVLPREEVVRLLRHEGDFLVR--ETTRNDECQTVLSVAWGG---HKHFIV 533

Query: 64  RES-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           + + +     +   FPTI EL+ +   +    +++ G   A+LK+ + R+ WEL ++DV+
Sbjct: 534 QTNLEGHFRFEGPSFPTIQELILYQYQSGLPVTSRSG---AILKKPILREVWELNNDDVQ 590

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L  K+G G FG+V+K KL            VAVKT ++ ++  E  ++ ++E R+++  D
Sbjct: 591 LLDKIGRGNFGDVYKAKLKSTNQ------EVAVKTCRV-ALPDENKRKFLQEGRILKQYD 643

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK--YELIYQAANGLAYIH 240
           H N+VK  G+    +P+ ++MEL  GG+L + L      + +K   ++    A+G+ Y+ 
Sbjct: 644 HPNIVKLIGICVQKQPIMIVMELVPGGSLLTFLRNNASTLTQKLLLKMCRDTASGMQYLE 703

Query: 241 EKNLMHRDVAARNCLYGGGQVL 262
            +N +HRD+AARNCL G   ++
Sbjct: 704 SRNCIHRDLAARNCLIGYENMV 725


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  286 bits (733), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 77/267 (28%), Positives = 125/267 (46%), Gaps = 29/267 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+         H+
Sbjct: 266 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYDGRVYHY 320

Query: 62  VVRES-DHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ--------AVER 111
            + E  D KV+V  +  F T+ ELV+H+    E        +    KQ        + E 
Sbjct: 321 RISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEP 380

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ 
Sbjct: 381 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT------VAVKTLKEDTM---ALKDF 431

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYEL 228
           + EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +
Sbjct: 432 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYM 491

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCL 255
             Q A+G++Y+  +N +HRD+AARNCL
Sbjct: 492 ATQIASGMSYLESRNYIHRDLAARNCL 518


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score =  284 bits (728), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 91/295 (30%), Positives = 144/295 (48%), Gaps = 51/295 (17%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           ++ L  Q +YHG +PR ++Q++L K G FL+R S+   G    +VLSV      +  HF+
Sbjct: 520 ERPLEQQTWYHGAIPRLEVQQLLTKDGDFLVRKSQEKPG----YVLSV--HWSGACKHFL 573

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           V+  D+   +D   F TI +L+  Y ++++  + K    + VL++ V + KW L H+D+ 
Sbjct: 574 VQNKDNMYCLDGESFHTIPQLIQQYQTSQQHVTKKS---EVVLRRPVLKDKWVLEHDDII 630

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA------- 175
           L   +G G FGEV+KG+L            VAVKT K  ++  EQ  + + EA       
Sbjct: 631 LGHIIGRGNFGEVYKGQLRP------DNTPVAVKTCK-NNLPLEQKSKFLIEARSAHTHT 683

Query: 176 -------------------------RLMRNLDHINVVKFFGVAAGTEPLYVIMELADG-G 209
                                    R+++  DH NVVK  GV    +P+Y++MEL  G G
Sbjct: 684 HTHTHTHTHTHAHAHAALYSHPTLSRILKQYDHPNVVKLIGVCTQKQPIYIVMELIQGSG 743

Query: 210 ALDSALGKLHFPMIKK--YELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              + L      +  K   ++    A+G+AY+  K  +HRD+AARNCL      +
Sbjct: 744 DFLTFLRNQGRDLKPKALVKMAENVASGMAYLESKKCIHRDLAARNCLVAENNSV 798


>UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76978_9METZ
          Length = 879

 Score =  283 bits (725), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 79/262 (30%), Positives = 142/262 (54%), Gaps = 24/262 (9%)

Query: 7   LHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
             + +YHG + R++   +L K G FL+R S     +K  + L+V  E      HF+++ +
Sbjct: 513 EEEPWYHGEISRQEATGLLKKMGDFLVRYS----ADKEHYTLTVKMEG---IKHFIIQHN 565

Query: 67  DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ---KWELYHEDVEL 123
           +     +   +P+I  L++H+   +   + K    +A+L+Q V++    ++ + H+++ +
Sbjct: 566 EEGFRFEGDPYPSIPMLIDHHFKNRLPVTRKS---QAILRQPVKKPDLREYNISHDNILI 622

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
            +K+G+G FG+V+KG L          + VAVK+ + E    +Q  + ++EA +++   H
Sbjct: 623 GEKIGKGNFGDVFKGYLKTHN------MEVAVKSCRSEDFPDKQ--KFLQEAEILKQYRH 674

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIYQAANGLAYIH 240
            N+V+  GV A  EPLY+IMEL  GG   S L         +    E+  +AA G+ ++ 
Sbjct: 675 PNIVELIGVCAEKEPLYIIMELMAGGNFLSFLRGPEGKRLKVNNLTEMCVEAAAGMVFLE 734

Query: 241 EKNLMHRDVAARNCLYGGGQVL 262
           ++N +HRD+AARNCL G   VL
Sbjct: 735 QRNCIHRDLAARNCLVGDNNVL 756


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  282 bits (723), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 74/274 (27%), Positives = 126/274 (45%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R D + +L     G FL+R SE   G   Q+ +SV  + +    H+
Sbjct: 187 NSLDKYTWYHGKISRSDSEAILGSGITGSFLVRESETSIG---QYTISVRHDGR--VFHY 241

Query: 62  VVR--ESDHKVYVDKIGFPTIIELVNHYVSTKESF--------STKDGTVKAVLKQAVER 111
            +    ++      ++ F T+ ELV+H+    +          S KD             
Sbjct: 242 RINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRGLFSLSPNAP 301

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WEL   ++ +  KLG G +G+V++G   +          +AVK  K ++M    + E 
Sbjct: 302 DEWELDRSEIIMHNKLGGGQYGDVYEGYWKRH------DCTIAVKALKEDAMP---LHEF 352

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYEL 228
           + EA +M++L H N+V+  GV     P Y+I E    G L   L +      P I   ++
Sbjct: 353 LAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQM 412

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+  ++ +HRD+AARNCL     ++
Sbjct: 413 ASQIASGMSYLEARHFIHRDLAARNCLVSEHNIV 446


>UniRef50_C4Q4A1 Term=tyrosine kinase
           5;db_xref=PMID:11289068;with=UniProt:Q9NH62;evidence=tra
           cea ble author statement n=2 Tax=Schistosoma mansoni
           RepID=C4Q4A1_SCHMA
          Length = 653

 Score =  281 bits (720), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 79/279 (28%), Positives = 133/279 (47%), Gaps = 35/279 (12%)

Query: 5   DLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKK----- 55
            +  ++++  +L R+D + +L    N  G FL+R SE  +G      LSV  E++     
Sbjct: 173 SVEAEEWFMPMLSRKDSERLLLLEGNAQGVFLVRESETSQG---SLTLSVRDEERGLSGI 229

Query: 56  -TSANHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE-- 110
             +  H+ ++  D++ Y    K  F ++ EL+  Y         K               
Sbjct: 230 MNTVKHYRIKHPDYRYYYITTKCSFSSLQELIQFYSIDSHGLCCKLTRACLCPPPITSDL 289

Query: 111 ----RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKE 166
               +  WE+    + L +KLG G FGEVWKG         +    VAVKT K  +MTKE
Sbjct: 290 SVKTKDHWEISKSSIVLIEKLGAGQFGEVWKGTW-------NGTTEVAVKTLKQGTMTKE 342

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMI 223
              + ++EAR+MR   H  +V+ + V    +P+Y++ EL   G+L   L      +  + 
Sbjct: 343 ---DFLKEARIMRAAQHPKLVRLYAVCT-EDPIYIVTELMCNGSLLQYLRDGPGKNLLIN 398

Query: 224 KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +  +++ Q ANG+AY+ +++ +HRD+AARN L G    +
Sbjct: 399 QLVDMMAQIANGMAYLEKEHYIHRDLAARNILVGENNCV 437


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  281 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 78/274 (28%), Positives = 138/274 (50%), Gaps = 30/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           K L  ++++ G + R + ++MLN+     G FL+R SE   G+   F LSV  + +    
Sbjct: 115 KSLDAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGD---FSLSV--KDQDRVR 169

Query: 60  HFVVRES-DHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAV-------E 110
           H+ VR   D  ++V +   F  + ELV+HY    +    K        ++          
Sbjct: 170 HYRVRRLEDGSLFVTRRSTFQILHELVDHYKIETDGLCCKLLYPCLQAEKPQTAGLLRQA 229

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
            ++WE+    ++L ++LG G FGEVW+G         +    VAVKT K  +M+   ++E
Sbjct: 230 NEEWEIEKTQIKLLRRLGAGQFGEVWEGLW-------NGTTSVAVKTLKPGTMS---VEE 279

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYEL 228
            ++EA +M+ L H  +++ + V    EP+Y++ EL   G+L   L        + +  ++
Sbjct: 280 FLQEASIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQLVDV 339

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+ ++N +HRD+AARN L G   + 
Sbjct: 340 AAQVASGMSYLEQQNYIHRDLAARNILVGEHGIC 373


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score =  281 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 75/271 (27%), Positives = 121/271 (44%), Gaps = 28/271 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L  +K+YHG + R   + +LN    G FL+R SE   G   Q  +S+  E +    H+ +
Sbjct: 162 LESEKWYHGAIQRSYAEYLLNSGITGSFLIRESESHPG---QLTISLRYEGQIW--HYRI 216

Query: 64  RESDHKVY--VDKIGFPTIIELVNHYVSTKESFST-------KDGTVKAVLKQAVERQKW 114
              D  +Y  ++   F ++ +LV+H+    +  +        K     + L+        
Sbjct: 217 HRDDSNMYYVIESNKFTSVSDLVHHHEKHSDGLACTLLYPAPKRDRTSSELRMDPSFDIR 276

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+   ++ +  KLG G +G V++             VLVAVKT K     ++   E + E
Sbjct: 277 EIDRTEIVMKHKLGSGQYGVVYEAVWKPYN------VLVAVKTLKENVTVRD---EFLEE 327

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIYQ 231
           ARLM++L H N+V   G      P Y++ E    G L   L    +          +  Q
Sbjct: 328 ARLMKSLRHPNLVTLLGACTREPPYYIVTEFMCNGNLLDYLRTHPRTELTPSVLLHMATQ 387

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            A G+AY+ + N +HRD+AARNCL G    +
Sbjct: 388 VARGMAYLEQHNFIHRDLAARNCLVGTQHTI 418


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score =  280 bits (718), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 83/262 (31%), Positives = 142/262 (54%), Gaps = 18/262 (6%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           K +  Q ++HG +PR +   +L + G FLLR S    G+   FVLS   + +    HF V
Sbjct: 463 KTIKEQTWFHGTIPRTESLRLLQQDGDFLLRESNNSLGD---FVLSAKADGQ--VRHFKV 517

Query: 64  RESDHKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           + +D+ +Y  +   FPT++ L++H+   +E  + +      +L   + + KW+L H+D  
Sbjct: 518 QVTDNGMYRFEADQFPTVLNLISHHYQKREPVTKR---TNCLLLNPICKDKWQLSHDDFT 574

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           +  K+G+G FGEV+K   ++      +   VAVKT K E++     ++ + EA++++  D
Sbjct: 575 IDCKIGQGNFGEVYKALFIR------ENYYVAVKTCK-ETVDNNTKEKFLMEAKILKGYD 627

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK--YELIYQAANGLAYIH 240
           H N+V+  GV    +P+Y++ME   GG L   L +    +  +   +  + A  GLAY+ 
Sbjct: 628 HKNIVRLIGVCTDRQPIYIVMEFVSGGDLVKYLKQNQHELCPRHLVQFCHDACMGLAYLE 687

Query: 241 EKNLMHRDVAARNCLYGGGQVL 262
           +K  +HRDVAARNCL     V+
Sbjct: 688 DKKCIHRDVAARNCLVSDDLVV 709


>UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QDY0_BRUMA
          Length = 384

 Score =  280 bits (718), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 102/256 (39%), Positives = 153/256 (59%), Gaps = 11/256 (4%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           +  L   ++YHGLLPR+DI  +L+K GQFL+R +E  KGE  Q VLSV    KT   HF+
Sbjct: 5   EPGLEFAEWYHGLLPRKDINILLSKQGQFLVRETEIKKGEGLQLVLSVKWNDKTM--HFI 62

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           +R  D KV+++K  F +I  L+ +++ +K+  + + G   A+L  AV RQ WE+ HE +E
Sbjct: 63  IRHVDGKVFIEKRQFNSIHALIRYHLVSKDPITDQSG---AMLLHAVPRQSWEVRHEQIE 119

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L + LGEGA   V+KG    I   +     VA+K  K   + +E +++I REAR+MR L+
Sbjct: 120 LHELLGEGAMSAVYKG----IFRGDESEKQVAIKVRKGRRLDRETVEQICREARIMRRLE 175

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAYIH 240
           H NVV+ +G+A   EP+ ++MEL   G+LD  L          +K       A+GL ++H
Sbjct: 176 HPNVVRLYGIAISKEPIMLLMELLKDGSLDVFLVTKGSKLSTREKLYFCLDIASGLEFLH 235

Query: 241 EKNLMHRDVAARNCLY 256
              ++HRD++ARNCL 
Sbjct: 236 NNGVIHRDISARNCLV 251


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score =  280 bits (716), Expect = 5e-74,   Method: Composition-based stats.
 Identities = 70/268 (26%), Positives = 122/268 (45%), Gaps = 26/268 (9%)

Query: 6   LLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           L  + ++ G + R +   ML    + G FL+R SE   GE   + LS+         H+ 
Sbjct: 340 LEGEPWFRGRISRAEAAAMLQITKQEGCFLVRESETQPGE---YTLSLSHN--EGVRHYR 394

Query: 63  VRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTV----KAVLKQAVERQKWELY 117
           ++  + + +V +   F +I +L+ ++        T+         A +   +    WEL 
Sbjct: 395 IQHIEGQYFVNENHRFDSIPQLIEYHKLNGGGIVTRLRRAINDANAPISVGLGHDMWELS 454

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
            ++ EL ++LG G FG V + +             VA+K  K   M+ +   + + EA +
Sbjct: 455 RDEFELGRELGSGQFGIVQQARYRN-------GQAVAIKMMKEGKMSAD---DFISEAVV 504

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIYQAAN 234
           MR+L H ++V+  GV     PL++I EL   G L + L    +L       + +    A+
Sbjct: 505 MRDLSHPHLVQLLGVCTKGGPLWIITELMSKGCLLNYLRDHKELRGEPQILHMMCVHIAS 564

Query: 235 GLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + Y+  K  +HRD+AARNCL G   V+
Sbjct: 565 AMEYLESKGFIHRDLAARNCLLGDNYVV 592


>UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepID=Q8T6F8_CAEEL
          Length = 533

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 78/273 (28%), Positives = 126/273 (46%), Gaps = 32/273 (11%)

Query: 5   DLLHQKYYHGLLPREDIQEM-LNKP---GQFLLRTSEPVKGEKRQFVLSVVG----EKKT 56
            +  +++Y G +PR   + + L+     G FL+R  E    + R+F L++          
Sbjct: 132 TIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIRERE---ADTREFALTIRDTDDQRNGG 188

Query: 57  SANHFVVRESD---HKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE--- 110
           +  H+ ++  D         +  F ++ ELV +Y    +    +       L        
Sbjct: 189 TVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLS 248

Query: 111 ---RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
              +Q WE+    + L +KLG+G FGEVW GK   I       V VA+KT K  +M+ E 
Sbjct: 249 HDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGI-------VEVAIKTMKPGTMSPEA 301

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKK 225
               ++EA++M+  DH N+VK + V    EP Y+I E    G+L   L        +   
Sbjct: 302 ---FLQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQAL 358

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
            ++  Q ANG+ Y+ E+ L+HRD+AARN L G 
Sbjct: 359 VDMAAQIANGMMYLEERKLVHRDLAARNVLVGD 391


>UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes related) tyrosine kinase
           (phosphoprotein NCP94), partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E47E92
          Length = 527

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 85/266 (31%), Positives = 149/266 (56%), Gaps = 20/266 (7%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           T+  L  +++YHG LPR++ + +L   G F++R      G   ++VLS     K    HF
Sbjct: 198 TELRLEEEEFYHGALPRKETEALLVNDGDFVVREKSDAWG---RYVLSAKHASK--VRHF 252

Query: 62  VVRESDHKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWE--LYH 118
            ++ +D  +Y ++   F T+ EL+   +++++  +      +A+L + V R + E  L H
Sbjct: 253 PIQINDENMYRLEGDAFQTVGELIRFQLNSRQPVTKAS---QAILLKPVCRVRNEHDLRH 309

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           E+++L +KLG G FG+V +G++ +        + VAVKT K E++     ++ ++EA ++
Sbjct: 310 EEIDLEEKLGAGHFGDVHRGRIKRT------QLAVAVKTCK-ETVDAATRRKFLQEANIL 362

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYELIYQAANGL 236
           +  DH N+VK  GV     P+Y++MEL  GG L S L   +      ++ ++   AA+G+
Sbjct: 363 KQYDHANIVKLIGVCTDKHPIYIVMELVPGGDLLSFLRTDQNELSTKQRVKMGEDAASGM 422

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQVL 262
           AY+  K  +HRD+AARNCL G   V+
Sbjct: 423 AYLESKQCIHRDLAARNCLVGNKNVI 448


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  278 bits (711), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 73/271 (26%), Positives = 125/271 (46%), Gaps = 29/271 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           KD+    +YH  + R   + +L     G FL+R S    GE   + +++  + K    H+
Sbjct: 121 KDINRNPWYHSNISRNTAEYLLKSGVDGSFLVRESLSSPGE---YSITLRCDGKART-HY 176

Query: 62  VVRESDHKVYVDKIGF-PTIIELVNHYVSTKESF-------STKDGTVKAVLKQAVERQK 113
            +       +V    F  T+ +LV H+    +           +    K ++    E ++
Sbjct: 177 RINHDARGYFVAAGKFFATVEQLVAHHAVVADGLVACLKQHPVEKAEAKPLVLSKEEDEQ 236

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   ++ L  +LGEG +GEV+ G+          P  VA+KT K  +M   + K+ M+
Sbjct: 237 WEIARSEIVLGHRLGEGQYGEVYVGEW--------GPHRVAIKTIKDGAM---EAKDFMK 285

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL----GKLHFPMIKKYELI 229
           EA +M+ + H N+V+  GV     PL+++ E  + G L   L    G+            
Sbjct: 286 EADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQSERGRAEIDPTSMMHCA 345

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
            Q A G++++ EK+ +HRD+AARNCL G   
Sbjct: 346 LQIAEGMSFLEEKHFIHRDLAARNCLVGDNL 376


>UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y1_9METZ
          Length = 893

 Score =  278 bits (711), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 80/269 (29%), Positives = 143/269 (53%), Gaps = 27/269 (10%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           +  +  +++++  + R++ +E     G +L+R S        ++VL+V    +    HFV
Sbjct: 518 ETRVEEERWFYPNMERKEAEEKCKNTGDYLIRYSSKQ----NRYVLTVCWAGQG--KHFV 571

Query: 63  VRESDH-----KVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ--KWE 115
           ++E+       K   +   FP++ EL++ +V+++   +   G   A+L + + R+  KW 
Sbjct: 572 IQEAPDEQTKTKYRFESRSFPSVRELLDFHVNSQTPVTKASG---AILSRPILREDDKWA 628

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           L HED+++ +KLG+GAFG+VW+  L            VAVKT +   +     ++ ++EA
Sbjct: 629 LKHEDIKMGRKLGKGAFGDVWEAALKGQGK-------VAVKTCRSTDVP--DREKFLQEA 679

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAA 233
            +++  DH N+VK  GV+  TEP+ ++MEL  GG+L   L K        K   +   A 
Sbjct: 680 EILKQYDHPNIVKLIGVSWDTEPVLIVMELMPGGSLLDYLRKKAAQMTKGKLLHMSIDAC 739

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            G+ Y+  KN +HRD+AARNCL G   ++
Sbjct: 740 GGMEYLESKNCIHRDLAARNCLVGENDIV 768


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score =  277 bits (709), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 69/271 (25%), Positives = 124/271 (45%), Gaps = 27/271 (9%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
            L    +YHG + R   + +L+    G FL+R SE  +G      LSV      S  H+ 
Sbjct: 81  SLNMHTWYHGAVSRAAAEYLLSSGINGSFLVRDSESCRGH-----LSVSVRFNASVYHYR 135

Query: 63  VR-ESDHKVYV-DKIGFPTIIELVNHYVSTKESF------STKDGTVKAVLKQAVERQKW 114
           +  ++    Y+  +  F T+ ELV+H+    +             T  AV   A +  +W
Sbjct: 136 INVDTAGLFYISPEHRFQTLPELVHHHSYASDGLAAILHYPAAKSTKPAVYSMAPDYDEW 195

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+   ++ + ++LG G +G+V++    +          +AVKT + ++   E   E ++E
Sbjct: 196 EIDRSEIHMKQRLGGGQYGDVYEAVWKRYNKT------IAVKTFREDTTNTE---EFLKE 246

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK---KYELIYQ 231
           A +M+++ H N+V+  GV     P Y++ E    G L   L + +   +       +  Q
Sbjct: 247 AAVMKSIKHPNLVQLLGVCTREPPFYIVTEFMSEGNLLEYLRRCNKVELDGVVLLHISVQ 306

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            A  + Y+  +N +HRD+AARNCL     ++
Sbjct: 307 VALAMEYLETRNYIHRDLAARNCLVEDNNLV 337


>UniRef50_A8XAK9 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8XAK9_CAEBR
          Length = 417

 Score =  276 bits (706), Expect = 6e-73,   Method: Composition-based stats.
 Identities = 159/243 (65%), Positives = 178/243 (73%), Gaps = 41/243 (16%)

Query: 20  DIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHK-VYVDKIGFP 78
           +  EML+KPG FL+RTSEP+KG+ RQF+LS +G  ++S NHFV+RES++K V+VD+ GF 
Sbjct: 53  ETSEMLHKPGDFLVRTSEPIKGQPRQFILSAIGSGQSSLNHFVIRESENKKVFVDQRGFS 112

Query: 79  TIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKG 138
           TIIELVNHYVS K+   TKD  VK VLK AVERQKWEL HEDV+LTKKLGEGAFGEVWKG
Sbjct: 113 TIIELVNHYVSQKDPIFTKDQKVKVVLKNAVERQKWELQHEDVQLTKKLGEGAFGEVWKG 172

Query: 139 KLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEP 198
           KL                                        L HINVVKF+GVAAGTEP
Sbjct: 173 KL----------------------------------------LKHINVVKFYGVAAGTEP 192

Query: 199 LYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           LYVIMELADGGALDSAL K +FPMIKKYE+IYQAA GLAYIHEK LMHRDVAARNCLYGG
Sbjct: 193 LYVIMELADGGALDSALSKQNFPMIKKYEMIYQAACGLAYIHEKELMHRDVAARNCLYGG 252

Query: 259 GQV 261
           GQV
Sbjct: 253 GQV 255


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  275 bits (705), Expect = 9e-73,   Method: Composition-based stats.
 Identities = 76/274 (27%), Positives = 123/274 (44%), Gaps = 26/274 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
             +  +++Y G L R+D +  L    N  G FL+R SE  KG     +      K     
Sbjct: 142 DSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVK 201

Query: 60  HFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTK------DGTVKAVLKQAVER 111
           H+ +R+ D+  Y    +  F T+ +LV HY         +       G  +        +
Sbjct: 202 HYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTK 261

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             WE+  E ++L K+LG G FGEVW G         +    VA+KT K  +M+ E     
Sbjct: 262 DVWEIPRESLQLIKRLGNGQFGEVWMGTW-------NGNTKVAIKTLKPGTMSPES---F 311

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYEL 228
           + EA++M+ L H  +V+ + V +  EP+Y++ E  + G+L   L         +    ++
Sbjct: 312 LEEAQIMKKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDM 370

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A G+AYI   N +HRD+ + N L G G + 
Sbjct: 371 AAQVAAGMAYIERMNYIHRDLRSANILVGNGLIC 404


>UniRef50_Q7YSY1 Fes-like tyrosine kinase protein n=5 Tax=Schistosoma mansoni
            RepID=Q7YSY1_SCHMA
          Length = 1259

 Score =  275 bits (705), Expect = 9e-73,   Method: Composition-based stats.
 Identities = 81/297 (27%), Positives = 142/297 (47%), Gaps = 52/297 (17%)

Query: 1    MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSE----------------------- 37
            + D D+  + ++HG+LPR +++ +L   G FL+R +                        
Sbjct: 811  ICDMDINKEPWFHGVLPRAEVERLLQNQGDFLVRQTSKRSSGRDTIGHWNGTNGDLINGN 870

Query: 38   ----------PVKGEKRQFVLSVVGEKKTSANHFVVR---ESDHKVYVDKIGFPTIIELV 84
                       + G   + VLSV         HF++    E+    +++   F TI EL+
Sbjct: 871  HNETILNKDHNMDGTVLRMVLSVFWHG---HRHFILYGGPETGEGWHLEDGHFSTIRELI 927

Query: 85   NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKIL 144
             +++ T+   + K G   A L   + R  WEL + DV+L +K+G+G FG+V++G      
Sbjct: 928  EYHMKTQTPVTAKSG---ACLVTPISRPDWELDNRDVQLLQKIGQGNFGDVYRGVY---- 980

Query: 145  DANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIME 204
                    VAVKT +++    +  ++ ++      N +H N+VK  G+A  + P+ ++ME
Sbjct: 981  ----NGCEVAVKTCRVDMTASDLRRKFLQGETTALNFNHPNIVKLVGIAVQSYPIMIVME 1036

Query: 205  LADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
               GG+L + L K     P++K  ++   AANG+ Y+  +N +HRD+AARNCL    
Sbjct: 1037 YVPGGSLLNHLRKSKNALPVMKLLQMSLDAANGMMYLEARNCIHRDLAARNCLISDD 1093


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score =  275 bits (703), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 68/271 (25%), Positives = 130/271 (47%), Gaps = 28/271 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGE-KKTSANHF 61
           L   ++Y G + R+  + +L    K G F++R S      K  + LS+  +  ++   H+
Sbjct: 405 LERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST----KGLYTLSLHTKVPQSHVKHY 460

Query: 62  VVRESD--HKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVK----AVLKQAVERQKWE 115
            ++++        +K    TI +L+N++       + +  +            +   KWE
Sbjct: 461 HIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWE 520

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           ++  ++ L ++LG G FG V +GK    +D        AVK  K  +M+++   + + EA
Sbjct: 521 IHPMELMLMEELGSGQFGVVRRGKWRGSIDT-------AVKMMKEGTMSED---DFIEEA 570

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI----KKYELIYQ 231
           ++M  L H N+V+ +GV +   P+Y++ E    G+L + L +    +I       ++  Q
Sbjct: 571 KVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQ 630

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + G+ Y+   N +HRD+AARNCL G   V+
Sbjct: 631 VSKGMTYLERHNYIHRDLAARNCLVGSENVV 661


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score =  274 bits (701), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 76/287 (26%), Positives = 129/287 (44%), Gaps = 43/287 (14%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           K L  + ++ G + R   +++L     K G FL+R SE   G    F LS+  +   +  
Sbjct: 334 KSLEAEPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPG---TFSLSM--KDGENVR 388

Query: 60  HFVVRESDHKVYVD---KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE-----R 111
           HF V++    + +          +  L+ ++   +   +T          +A +     +
Sbjct: 389 HFRVKKVAGGIKLQGSPSSPHKDLPSLIKYHKRHRGGLTTTLKVPCPREIRAPDIGYAVK 448

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            KWE+  + + L K+LGEG +GEV+KG+        +    VA+KT K  + + E   E 
Sbjct: 449 DKWEVDRDTIVLEKQLGEGQYGEVYKGRW-------NGTTEVAIKTLKSAATSAE---EF 498

Query: 172 MREARLMR-------------NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK- 217
           ++EA+LM+              L H N+VK   V    EP+++I EL   G+L   L   
Sbjct: 499 LQEAQLMKVRARVGIALARARKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLDYLRSP 558

Query: 218 --LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                 +    ++    A+G+AY+ E N +HRD+AARN L G   + 
Sbjct: 559 AGESLRLPTLIDMASDVAHGMAYLEENNYIHRDLAARNILVGENNIC 605


>UniRef50_A8PMN8 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8PMN8_BRUMA
          Length = 420

 Score =  274 bits (701), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 86/258 (33%), Positives = 143/258 (55%), Gaps = 12/258 (4%)

Query: 7   LHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
             + +YHG +   + + +L   G FL+R +E + GE  Q+V++V+ E      +F+++++
Sbjct: 31  EDEPFYHGFMSNNECKPLLTNAGDFLVRRAE-IDGEM-QYVITVLPENSNEITNFIIKKT 88

Query: 67  --DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT 124
              H  YV    F TI +L+ ++   K+  + ++      + + + R  W+L HE +E  
Sbjct: 89  RPKHLYYVYIYAFKTISDLIAYHSRMKKPLNNEN----VCILKGIARSDWQLAHEQIERN 144

Query: 125 KKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHI 184
           KKLGEGAFGEVW+G L   L      + VA+KT    +++ ++  + +REA LM  L H 
Sbjct: 145 KKLGEGAFGEVWEGTL--NLGVFRGYIPVAIKTLHSGNISADERIKFLREANLMLKLSHP 202

Query: 185 NVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI--KKYELIYQAANGLAYIHEK 242
           N++KF+GVA   +P+ ++ME A GG+L + +     P     K      AA+GLAY+   
Sbjct: 203 NIIKFYGVATLKDPIMIVMEFASGGSLLARVQNTKRPPTDADKIRYCAGAASGLAYLETM 262

Query: 243 NLMHRDVAARNCLYGGGQ 260
            ++HRD+AARNCL     
Sbjct: 263 QIIHRDIAARNCLLSADD 280


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score =  274 bits (701), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 75/269 (27%), Positives = 126/269 (46%), Gaps = 28/269 (10%)

Query: 6   LLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           +  + ++HG + R +   +L    + G FL+R SE   GE   + LSV      S  H+ 
Sbjct: 297 IESEAWFHGRISRAEAAALLHVAKQEGCFLVRESESKVGE---YSLSVSH--GDSLRHYH 351

Query: 63  VRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA----VERQKWELY 117
           +++   + Y+ D+  FP I +L+ ++        T+     A L       +   KWEL 
Sbjct: 352 IKKEGEEFYINDRHRFPDICKLIEYHKLNSGGLVTRLRKSIADLHTPAAAGLGHGKWELD 411

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
             D  + ++LG G FG V +   +           VAVK  K  +M+++   + + EA  
Sbjct: 412 PADFAIGRQLGSGQFGVVHEATYIG-------EKKVAVKMMKQGTMSED---DFISEALA 461

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL----HFPMIKKYELIYQAA 233
           M+N  H N+V+ +GV   T P+++I E+   G L   L       H P + +Y +  Q A
Sbjct: 462 MKNFTHPNLVQLYGVCTRTRPMWIITEIMTQGCLLDHLRNNQDLQHRPELLQY-MGVQIA 520

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + Y+     +HRD+AARNCL G   ++
Sbjct: 521 AAMMYLESLRFIHRDLAARNCLLGEKYIV 549


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 76/278 (27%), Positives = 131/278 (47%), Gaps = 32/278 (11%)

Query: 5   DLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQ-FVLSVVGEKKTSAN 59
            L  + +Y G + R D +++L    ++ G FL+R SE   G+    F LSV    K    
Sbjct: 123 TLEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSV--RDKELIR 180

Query: 60  HFVVRESDHKVYVDKIG--FPTIIELVNHYVSTKESFSTK----DGTVKAVLKQAVE--- 110
           H+ ++ +D   Y   +   F T+ EL+  Y  + +    K       V  + K+ V+   
Sbjct: 181 HYRIKITDSGKYFISLSKEFSTLNELIEFYKISSDGLKIKLLEPCRKVCIMFKKQVQTFG 240

Query: 111 ---RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
              + KWE+  + +E   ++G G FG+V+KG         +  + VA+K+ K   M K  
Sbjct: 241 LSHKDKWEISRDSLEFQSRVGSGQFGDVYKGVW-------NSKIPVAIKSLKPGYMDK-- 291

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIK 224
            K+ + EA LM+ L H  +V+ + V    EPL ++ E    G+L   L           +
Sbjct: 292 -KQFLAEANLMKQLRHPKLVQLYAVVTIEEPLLIVTEFMSNGSLLEFLRHNESKKLLFKE 350

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             ++  + A G+A++  K+ +HRD+AARN L G   ++
Sbjct: 351 LIDICAEVAQGMAFLELKSFIHRDLAARNILVGEHNLV 388


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 73/268 (27%), Positives = 120/268 (44%), Gaps = 27/268 (10%)

Query: 7   LHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
             + +Y G + R + Q  L   N  G FL+R SE   G    + LSV    +    ++ +
Sbjct: 254 ESEPWYVGKMSRVEAQSKLQIFNLDGTFLVRESETSAG---SYTLSVYFNGQP--RNYRI 308

Query: 64  RESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTV----KAVLKQAVERQKWELYH 118
           +   ++ Y+  +    TI EL++++        T+        +A     +   KWE+  
Sbjct: 309 QHDGNEYYITTRHRQKTIKELIDYHKLNGGGLCTRLKKPACDDEAPTPHDLGSDKWEIDP 368

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
            ++ L K LG G FG V+KGK   + D       VAVK  K  +M ++   E + EA +M
Sbjct: 369 SEISLGKVLGSGQFGVVYKGKFQGVTD-------VAVKKVKGGAMAED---EFIAEAEIM 418

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI----KKYELIYQAAN 234
           +   H N+V  +GV     PL ++ E    G L + L   +  +         +  Q AN
Sbjct: 419 KQFKHKNLVNLYGVVTKKRPLMIVTEFMRNGCLLNYLRDHNSELQGRAPVLLYMSIQVAN 478

Query: 235 GLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + ++ E   +HRD+AARNCL G    +
Sbjct: 479 AMVFLEEHGFIHRDLAARNCLVGEHYAV 506


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 72/269 (26%), Positives = 123/269 (45%), Gaps = 24/269 (8%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L  + YYHG +PR   +  L+    G FL+R S+   GE     +S+  + K    H+
Sbjct: 172 NSLDSEPYYHGRIPRTTAEFFLSNGINGSFLVRESQSNAGEH---TISLRCDGK--VFHY 226

Query: 62  VVRESDHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAV---ERQKWELY 117
            +  +D  V++     F T+ +LV  Y    +             +Q +      KWE+ 
Sbjct: 227 RISRTDKGVFIAADRVFSTVQDLVKFYHQQSDGLVHPLRHAVPKNRQEITASPSDKWEID 286

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
              + +  +LG G +GEV++  L       ++   VAVKT K E+M   + K+ ++EA +
Sbjct: 287 RSSIMMGTRLGAGQYGEVYEAVL------TNKNRHVAVKTLKEEAM---EAKDFLKEAEV 337

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG----KLHFPMIKKYELIYQAA 233
           M+ L H N+V+  GV     PLY++ E    G L   +     +          +  Q +
Sbjct: 338 MKKLKHPNLVELIGVCTLESPLYIVTEYMCNGCLLDYIRDPIKQKEITPTAMMYIAEQIS 397

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            G+ ++  +N +HRD+AARNCL     ++
Sbjct: 398 AGMEFLESQNFIHRDLAARNCLVADNLLV 426


>UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NNY7_BRUMA
          Length = 303

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 101/253 (39%), Positives = 146/253 (57%), Gaps = 14/253 (5%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV-RESDHK 69
           YYHGL+PR DI+ +L K G FLLR +E   GE    VL++      +  HF+V ++ D  
Sbjct: 24  YYHGLIPRTDIEPLLKKEGDFLLRKTELTPGE---IVLAISVRHNNAVRHFMVNQDQDGS 80

Query: 70  VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
            Y +     ++ +L+ +Y STKE  S      +A L++ +ER +W L H+ + L KKLGE
Sbjct: 81  FYCEHHHEKSVSDLIQYYKSTKEPLSASS---QARLRRPIERPQWLLNHDSIRLVKKLGE 137

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           GAFGEV+  +         +   VAVKT + E+ T+E   + M+EARLMR  +H +VV+ 
Sbjct: 138 GAFGEVFLAEY----SFGTEKQEVAVKTMRQEA-TREARLKFMKEARLMRRYEHKHVVRI 192

Query: 190 FGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHR 247
            GVA    PL +IME   GG+L S L K     P+  K     +AA+G+AY+H++  +HR
Sbjct: 193 LGVAVHEHPLMIIMENCPGGSLLSYLRKEKVKVPLAMKLRFATEAADGMAYLHKQKCIHR 252

Query: 248 DVAARNCLYGGGQ 260
           D+AARN L  G  
Sbjct: 253 DIAARNVLLSGKL 265


>UniRef50_Q4S351 Chromosome 4 SCAF14752, whole genome shotgun sequence n=2
           Tax=Tetraodon nigroviridis RepID=Q4S351_TETNG
          Length = 810

 Score =  273 bits (698), Expect = 5e-72,   Method: Composition-based stats.
 Identities = 89/263 (33%), Positives = 133/263 (50%), Gaps = 46/263 (17%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           +++ L  Q++YHG +PR + QE+L + G+FL                             
Sbjct: 470 SERPLAEQEWYHGAIPRTEAQELLRQQGEFL----------------------------- 500

Query: 62  VVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDV 121
                  +   +  GF TI +L+ H+ S+K+  + K G V  +L   V+ +KW L HEDV
Sbjct: 501 ------GQYRFEGTGFTTIPQLIEHHFSSKQVITKKSGVV--LLNPVVKDKKWILNHEDV 552

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
            L + LG+G FGEV+KG L +          VAVKT K +  ++ +I+  + EAR+++  
Sbjct: 553 VLGELLGKGNFGEVFKGTLQR------DKTPVAVKTCKEDLPSELKIR-FLSEARILKQY 605

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYI 239
           DH N+VK  GV    +P+Y++MEL  GG   S L K        +       AA G+AY+
Sbjct: 606 DHPNIVKLIGVCTQRQPIYIVMELVPGGDFLSYLRKKKDELKTKQLLRFAVDAAAGMAYL 665

Query: 240 HEKNLMHRDVAARNCLYGGGQVL 262
             KN +HRD+AARNCL G    L
Sbjct: 666 ESKNCIHRDLAARNCLVGDNNAL 688


>UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni RepID=Q70DV1_SCHMA
          Length = 647

 Score =  272 bits (697), Expect = 7e-72,   Method: Composition-based stats.
 Identities = 79/280 (28%), Positives = 126/280 (45%), Gaps = 37/280 (13%)

Query: 5   DLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
            L   ++Y G L R + +  L    N  G FL+R SE    E   + LSV  E   +  H
Sbjct: 216 SLESNEWYFGELKRIEAEHYLQLPGNDHGSFLVRISESQSSE---YSLSVREE--NTVKH 270

Query: 61  FVVR----ESD---HKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER- 111
           + +R     +D    + Y+ + + F  I +LVNHY+  +     + G             
Sbjct: 271 YRIRSRYSRTDPTLKRFYISRQLPFVNIQQLVNHYLENQSGLCCRLGKPCIRPTHPEPVG 330

Query: 112 ------QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTK 165
                  KWE+    + L +K+G+G FGEV+K          ++  +VAVKT K  S   
Sbjct: 331 LSHKLIDKWEIPKSSIILKEKIGQGQFGEVFKAVW-------NKTTIVAVKTLKPSSCDA 383

Query: 166 EQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPM 222
               + +REA+ M+ L H N+++ + V   TEP Y++ E    G+L + L         M
Sbjct: 384 A---DFLREAQTMKRLHHPNLIQLYAVCTQTEPFYIVTEYMSKGSLLNYLQSPEGNALNM 440

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                +  + A G+AY+  +  +HRD+AARN L G    +
Sbjct: 441 QCLIMMAAKIAPGMAYLESRRHIHRDLAARNVLVGEQHAV 480


>UniRef50_O17755 Protein F01D4.3, partially confirmed by transcript evidence n=2
           Tax=Caenorhabditis elegans RepID=O17755_CAEEL
          Length = 561

 Score =  269 bits (689), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 98/276 (35%), Positives = 153/276 (55%), Gaps = 25/276 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEK---RQFVLSVV--------G 52
             L    +YHG LPRED+   L+  G +L+R SE V+GE    R+ +LS++         
Sbjct: 143 MKLREFNFYHGFLPREDLHSTLHNSGDYLIRVSEVVEGETKVNREVILSLIPIQSDGKED 202

Query: 53  EKKTSANHFVVRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER 111
            +K +  + V++   +K + +    F ++ +L+ +Y  T  S S  +G  +  LK  + +
Sbjct: 203 TEKKNCRNVVIKRVGNKCFCEPTRTFESVTDLIKYY--TDNSGSCSNGRFQ--LKNPILQ 258

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLES-MTKEQIKE 170
           Q WE  H DV   K LGEGAFG+V+ G L      +     VA+K  K+ + ++K +IKE
Sbjct: 259 QPWEYMHSDVTAGKVLGEGAFGKVFSGTLKL---KDGSSAEVAIKMTKVSAFLSKIKIKE 315

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-----FPMIKK 225
           +M EAR +RN +H NVV+ +GVA   +PLY+++EL  GG+L   + K        P+ +K
Sbjct: 316 MMNEARFIRNFNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDHMKKAKATGTVVPIAEK 375

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
                 AA G+ Y+H+ N +HRD+AARNCL    +V
Sbjct: 376 VRFCIGAARGIEYLHQNNCIHRDIAARNCLLSEKEV 411


>UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Suberites domuncula
           RepID=Q7YZX2_SUBDO
          Length = 700

 Score =  269 bits (689), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 68/269 (25%), Positives = 121/269 (44%), Gaps = 26/269 (9%)

Query: 6   LLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           L  ++++   L R   + +L    + G F++R S      +  + LS+  E +    H  
Sbjct: 313 LDSEEWFFPQLSRTRAENILKGEGREGGFVVRNSSR----ENMYTLSICHEGQVRHYHIK 368

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ------AVERQKWEL 116
           + ES+     +K  FP+I EL+ ++        T+       L         +  + WE+
Sbjct: 369 LDESNKYFISEKHRFPSIKELIEYHKLNGGGLVTRLRKPPVQLAPNPQSLGPLFDEAWEI 428

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
               + L K+LG G FG V  GK           + VA+K  +  +M ++   + + EA+
Sbjct: 429 DKVSLSLGKELGSGQFGRVVSGKWKG-------KIDVAIKMMREGAMNED---DFIEEAK 478

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK---KYELIYQAA 233
           +M+   H N+VK +GV     P++++ EL   G L   L +    + K     ++  Q  
Sbjct: 479 VMKQFQHENLVKLYGVCTKNGPIFIVQELMVNGCLLQFLRQRKELVEKTEIILDMATQIC 538

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + + Y+ E   +HRD+AARNCL G   V+
Sbjct: 539 SAMKYLEESGFIHRDLAARNCLVGERNVV 567


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score =  268 bits (687), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 80/274 (29%), Positives = 127/274 (46%), Gaps = 30/274 (10%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNK---PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           D  L    + HG + R     +L +    G +L+R S+   G   Q+ L V  E K+   
Sbjct: 66  DGSLELFDWCHGAISRNGADYLLKQHGIDGMYLVRESQSQPG---QYTLDVWKEGKSV-- 120

Query: 60  HFVVRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAV------ERQ 112
           H+ + + D   +    + FPTI EL+ H+ +  +   +    +                +
Sbjct: 121 HYRITKGDEGYFFRQGVCFPTIPELIQHHQTRSDGLCSSLDHIAPKAHAKTIVIGMDMEK 180

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           KWEL   +V L  +LG G +GEV+KG              VA+KT K ESM   +  E M
Sbjct: 181 KWELKRSEVILGDRLGGGNYGEVFKGIY--------NNKTVAIKTIKEESM---ETVEFM 229

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG----KLHFPMIKKYEL 228
           +EA +M+ L H N+VK  GV +   P+Y++ E    G L S L     ++    +    +
Sbjct: 230 KEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLRLPQSRIQLDHVSMLYI 289

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++ +  +N +HRD+AARNCL G    +
Sbjct: 290 AQQIADGMSALEAQNTIHRDLAARNCLVGENLSV 323


>UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=O01325_CAEEL
          Length = 474

 Score =  268 bits (686), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 92/255 (36%), Positives = 140/255 (54%), Gaps = 12/255 (4%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           L  + +YHG + RE+ ++++   G+FLLR +E  K      VLSV  +     +H VV +
Sbjct: 86  LDDEPFYHGYMSREESEKLVRSQGEFLLRKTELTK-RGEVVVLSVFWD--EGVHHLVVEK 142

Query: 66  SDHK-VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT 124
           +++   Y+ +  F  I +LV ++  T+ S           L   V R++W+LYHE + L 
Sbjct: 143 ANNGLYYLKEFCFENISDLVRYHHQTRASVYKSGIK----LFSWVVREEWQLYHEQINLG 198

Query: 125 KKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHI 184
           KKLG G FGEV++G L   +  N   V VAVKT K   +T ++    +REA LM  L+H 
Sbjct: 199 KKLGNGEFGEVFQGVLSVGIFTND--VEVAVKTMKGSKVTADERITFLREANLMLKLNHK 256

Query: 185 NVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEK 242
            VV+ +GVA   EP+ ++MEL  GG L S + K       + K +   Q A G+ Y+ +K
Sbjct: 257 YVVRLYGVATQQEPIMIVMELCSGGCLKSRIEKKDEQLSDVLKRKYCKQIAKGMRYLEKK 316

Query: 243 NLMHRDVAARNCLYG 257
            ++HRD+AARN L  
Sbjct: 317 QVIHRDLAARNVLLD 331


>UniRef50_Q23554 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q23554_CAEEL
          Length = 419

 Score =  268 bits (686), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 97/265 (36%), Positives = 143/265 (53%), Gaps = 14/265 (5%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           T K      +YHGLLPR DI  +L   G FL+RTS  V  +  + VLSV  + K   +H+
Sbjct: 23  TRKKHQDMDWYHGLLPRADINTLLENDGDFLVRTSHIVGQDSAKTVLSVKWKGK--CHHW 80

Query: 62  VVRES-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
            ++E  D  + +++  F +++++V      +   S       A+L   + +Q WEL H+ 
Sbjct: 81  QLQEKEDGSIVIEERKFESVLDMVTTLRMKRLPVSAN---CPALLLNPINKQDWELRHDQ 137

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLES--MTKEQIKEIMREARLM 178
           ++L K LGEGAFG V+K           +  +VAVK  K      T+  I+++ +EAR+M
Sbjct: 138 IKLGKMLGEGAFGGVYKAAFYC----KGEKRMVAVKVNKGNEKISTRAMIEDVCKEARIM 193

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYELIYQAANGL 236
           R   H NVV FFGV    EP+ ++MELA  GALDS L   K +  +  K +  + A+ GL
Sbjct: 194 RQYQHPNVVCFFGVCVEKEPIMLVMELASQGALDSFLKNEKNNVSLRDKLKYSFDASKGL 253

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQV 261
            Y+H+   +HRDVAARN L     V
Sbjct: 254 EYLHQHGCIHRDVAARNFLMHKNVV 278


>UniRef50_Q9TYX4 Putative uncharacterized protein R11E3.1 n=3 Tax=root
           RepID=Q9TYX4_CAEEL
          Length = 549

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 103/287 (35%), Positives = 150/287 (52%), Gaps = 36/287 (12%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVK------GEKRQFVLSVVGE---- 53
           K L    +YHG LPR+D+  ++   G +L+R SE         G KR  +LSV       
Sbjct: 73  KSLQAMPFYHGFLPRDDLGVIIRNEGDYLIRVSEITTKKEGTTGIKRDIILSVCSSERGG 132

Query: 54  ------------------KKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFS 95
                              +    + V+R  D K  +    FPTI  L+ +Y  T    +
Sbjct: 133 TETEQTNTKSDAKSELNLGERKMRNMVIRRFDGKFGIKGNLFPTIEALLANYHVTNALET 192

Query: 96  TKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAV 155
            ++      LK  ++ Q WE  H  V+L  KLGEGA+GEV KG L +     ++ + VAV
Sbjct: 193 KENR----FLKTPIDLQVWENRHSAVKLGDKLGEGAYGEVRKGVLHR----KNKKLDVAV 244

Query: 156 KTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL 215
           K  K   + K +I+E+M EARLMRN  H N+V+FFGVA   +PLY+++EL +GGAL++ L
Sbjct: 245 KLMKGGELNKMKIREMMNEARLMRNFKHKNIVRFFGVAVVEQPLYILLELVNGGALNTYL 304

Query: 216 GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            K     ++   +   AA GL Y+H  + +HRD+AARNCLY   +V+
Sbjct: 305 QKNKVSDLELMRMCLGAAQGLQYLHANHCIHRDIAARNCLYSNDKVV 351


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 71/274 (25%), Positives = 127/274 (46%), Gaps = 31/274 (11%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
            +  L    ++HG + R++ + +L   + G FL+R S    G+   + L V  + K    
Sbjct: 675 CEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGD---YTLCVCFQSKVE-- 729

Query: 60  HFVVRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA--------VE 110
           H+ V+  ++K+ +D +  F  + +LV HY +  +   T+       L +           
Sbjct: 730 HYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFV 789

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
            + W +   +++L + +G+G FG+V  G L            VAVK  K E      +++
Sbjct: 790 DKGWVIPEAELQLRESIGKGEFGDVMLGILRNE--------KVAVKMLKDEGA----VQK 837

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYE 227
            + EA +M  L+H N+VKF G+   ++ LY++ E    G+L   L    + H     +  
Sbjct: 838 FLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQII 897

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
             Y  A+G+ Y+  K ++HRD+AARN L     V
Sbjct: 898 FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCV 931


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 71/274 (25%), Positives = 127/274 (46%), Gaps = 31/274 (11%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
            +  L    ++HG + R++ + +L   + G FL+R S    G+   + L V  + K    
Sbjct: 470 CEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGD---YTLCVCFQSKVE-- 524

Query: 60  HFVVRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA--------VE 110
           H+ V+  ++K+ +D +  F  + +LV HY +  +   T+       L +           
Sbjct: 525 HYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFV 584

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
            + W +   +++L + +G+G FG+V  G L            VAVK  K E      +++
Sbjct: 585 DKGWVIPEAELQLRESIGKGEFGDVMLGILRNE--------KVAVKMLKDEGA----VQK 632

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYE 227
            + EA +M  L+H N+VKF G+   ++ LY++ E    G+L   L    + H     +  
Sbjct: 633 FLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQII 692

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
             Y  A+G+ Y+  K ++HRD+AARN L     V
Sbjct: 693 FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCV 726


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score =  266 bits (681), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 68/270 (25%), Positives = 121/270 (44%), Gaps = 31/270 (11%)

Query: 6   LLHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L+   ++HG + RE  + +L   + G FL+R S    G+   + L V  + +   +H+ +
Sbjct: 96  LIPMPWFHGKISRELAESLLMPREDGLFLVRESAHFPGD---YTLCVCFQDQ--VDHYRM 150

Query: 64  RESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK--------W 114
           +  + K+ +D+ + F ++ ELV HY    +   T+    K V+KQ     K        W
Sbjct: 151 QGKNGKLTIDEEVYFSSLEELVQHYEKDADGLCTR--LRKPVVKQGGREFKIDARKFVNW 208

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+   ++  + ++G G FG+V++G              VA+KT K   +  + I + + E
Sbjct: 209 EISPREIVKSAQIGSGQFGDVFEGLYRGQ--------KVAIKTLK--DVQGDAIDQFLLE 258

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIYQ 231
           A  M  L H N+V+  GV     P+ ++ E    G L   L    +    +  +      
Sbjct: 259 ADTMTRLRHKNLVQLIGVCTQGSPIMIVSEFMGKGCLLDYLRSRGRAVINLATQLGFCRD 318

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
               + Y+ E+  +HRD+AARN L     V
Sbjct: 319 ICAAMEYLEEQKFVHRDLAARNILLSDDGV 348


>UniRef50_Q9N4T6 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q9N4T6_CAEEL
          Length = 448

 Score =  266 bits (681), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 101/269 (37%), Positives = 153/269 (56%), Gaps = 22/269 (8%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEK---RQFVLSVV-------- 51
           +  L H ++YHG LPRED+Q  L  PG FLLR SE V+GE    R+ +LS++        
Sbjct: 71  ELALRHFEFYHGFLPREDLQSTLQNPGDFLLRVSEVVEGENKVNREIILSLIPIQEEGKE 130

Query: 52  GEKKTSANHFVVRESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE 110
            E K    + V++ + +  + +    F +I EL+N+Y+  K + S    T +  L   + 
Sbjct: 131 DEDKIRTRNVVIKRAGYLFFCETTRSFDSIFELINYYM--KNTGSCSSATFQ--LLNPIL 186

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLES-MTKEQIK 169
           +Q WE  H DV + K LGEGAFG+V  G L      +   V VA+K  K+ + ++K +IK
Sbjct: 187 QQPWEYMHSDVTIGKVLGEGAFGKVCSGTLKL---KDGSNVEVAIKMTKVSAFLSKMKIK 243

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYE 227
           E+M EAR +RN +H NVV+ +GVA   +PLY+++EL  GG+L   + K      + ++  
Sbjct: 244 EMMNEARFIRNFNHKNVVRLYGVAHHEQPLYILLELVKGGSLQDHMKKEKGAVTIAERIR 303

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLY 256
               A  G+ Y+H+ N +HRD+AARNCL 
Sbjct: 304 FCCGAGRGIEYLHQNNCIHRDIAARNCLL 332


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score =  266 bits (681), Expect = 6e-70,   Method: Composition-based stats.
 Identities = 77/266 (28%), Positives = 125/266 (46%), Gaps = 21/266 (7%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
             +  +++++  + R+D +  L    NKPG +L+R SE  KG     +  V  + +    
Sbjct: 120 DTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVVK 179

Query: 60  HFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTK--DGTVKAVLKQAVERQKWE 115
           H+ +R  D+  Y    KI F  I  ++ HY    +    K      K   ++  ++  WE
Sbjct: 180 HYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKAQKPWDKDAWE 239

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +  + +++ KKLG G FGEVW           +    VAVKT K  +M+   ++  + EA
Sbjct: 240 ISKDSIKMVKKLGAGQFGEVWMAFY-------NNSTKVAVKTLKPGTMS---VEAFLEEA 289

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKYELIYQA 232
            LM+ L H  +V+ + V   TEP+Y+I E    G+L   L         + K  +   Q 
Sbjct: 290 NLMKTLQHDRLVRLYAVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSAQI 349

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGG 258
           A G+AYI +KN +HRD+ A N L   
Sbjct: 350 AEGMAYIEKKNYIHRDLRAANVLVSE 375


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score =  265 bits (679), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 73/276 (26%), Positives = 115/276 (41%), Gaps = 33/276 (11%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
            L    ++ G + R   ++ LN P    G FL+R SE   G   Q+ LS+      +  H
Sbjct: 231 SLESHAWFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPG---QYSLSL--RDGDTVRH 285

Query: 61  FVVRESDHKVY----VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE------ 110
           + V   +  +Y         F ++ EL+  +   K   +T            +       
Sbjct: 286 YRVENYEGGLYKLQGSPTQKFASLPELIAFHGQRKAGLATALREPCPKESAPMASDLTFD 345

Query: 111 -RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
              +WE+    ++L K LG G +GEV+ G              VAVKT K  S      K
Sbjct: 346 THDQWEVPRTSIKLGKLLGTGQYGEVYSGIFQD-------STKVAVKTLKAASANP---K 395

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKY 226
           + + EA +M+ L H+N+V    V +   P+ +I+EL   G+L   L         +    
Sbjct: 396 DFLAEATIMKKLRHLNIVSLLAVCSVGSPILIIVELLSKGSLLDFLRSDDAKELRIPNLV 455

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           ++  Q A G+AY+     +HRD+AARN L G   V 
Sbjct: 456 DMGAQVAAGMAYLESMKFIHRDLAARNVLVGDNNVC 491


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 71/269 (26%), Positives = 123/269 (45%), Gaps = 27/269 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           L  + ++     +     +LN   + G FL+R SE   G    + LSV  + K    H+ 
Sbjct: 277 LESEPWFMADTSKAMASALLNMCGQDGAFLVRESESTPG---SYSLSVFYQGK--LKHYK 331

Query: 63  VRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAV----ERQKWELY 117
           ++       V ++  F +I EL+ ++        T+           +       +WEL 
Sbjct: 332 IKHDQDMYRVSERHTFASISELIEYHKHNGGGLVTRLRKPVQDANTPITAGLGHDRWELD 391

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
             ++EL ++LG G FG V  G              VA+K  K  SM+++   + + EA++
Sbjct: 392 AREIELGRELGSGNFGVVRAGVYKSNR-------PVAIKMMKEGSMSED---DFIAEAQV 441

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY----QAA 233
           M    H N+V+  GV    +P+Y++ EL   G L   L K    +  K ++++    Q A
Sbjct: 442 MMKFRHKNLVELLGVVTSVKPIYIVTELMSNGNLLDYLKKNQSMLQGKPQILHYMSVQVA 501

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +G+A++ +   +HRD+AARNCL G   V+
Sbjct: 502 SGMAFLEDHGFIHRDLAARNCLVGDNNVV 530


>UniRef50_O01798 Defective spermatogenesis protein 8 n=3 Tax=Caenorhabditis
           RepID=O01798_CAEEL
          Length = 512

 Score =  264 bits (676), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 87/264 (32%), Positives = 141/264 (53%), Gaps = 15/264 (5%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           + ++ +  +YHG + R + + ML+  G FL+R +E   G++  +V+S+  + +    H +
Sbjct: 106 ENNIDNFPFYHGFMGRNECEAMLSNHGDFLIRMTEI--GKRVAYVISIKWKYQNI--HVL 161

Query: 63  VRESDHK--VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           V+ +  K   +  K  F +I EL+ ++    +        +       + R  W+L +E 
Sbjct: 162 VKRTKTKKLYWTKKYAFKSICELIAYHKRNHKPIYEGMTLIC-----GLARHGWQLNNEQ 216

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V L KKLGEG FGEV KG L   + A   PV VAVKT     ++  +    +REA +M  
Sbjct: 217 VTLNKKLGEGQFGEVHKGSLKTSVFA--APVTVAVKTLHQNHLSANEKILFLREANVMLT 274

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAY 238
           L H NV+KF+GV    EP+ ++ME  DG +L+ AL   +       K   ++ AA G+ Y
Sbjct: 275 LSHPNVIKFYGVCTMKEPIMIVMEFCDGKSLEDALLSKEEKVSAEDKILYLFHAACGIDY 334

Query: 239 IHEKNLMHRDVAARNCLYGGGQVL 262
           +H K ++HRD+AARNCL    ++L
Sbjct: 335 LHGKQVIHRDIAARNCLLNSKKIL 358


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score =  264 bits (676), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 70/268 (26%), Positives = 123/268 (45%), Gaps = 25/268 (9%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           +  L    ++HG + RE+ + +L   + G FL+R S    G+   + L V   +K    H
Sbjct: 370 NAKLNAMPWFHGRIKREEAENLLKPREDGLFLVRESTNFPGD---YTLCVCFNEKVE--H 424

Query: 61  FVVRESDHKVYVDKI-GFPTIIELVNHYVSTKESFSTKDGT---VKAVLKQAVERQKWEL 116
           + ++ +++K+ +D    F  + +LV HY    +   TK       +    +  +   WE+
Sbjct: 425 YRIKYAENKLTIDDDEYFDNLGQLVEHYTLDSDGLCTKLMKALPKEEFCVKDFQDNGWEI 484

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
             ED++L + +G+G FG+V  G L            VAVK  K       +    + EA 
Sbjct: 485 KMEDLQLKENIGKGEFGDVMLGILKGE--------KVAVKVLKDAGRASNK---FLAEAG 533

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIYQAA 233
           +M  L+H N+VKF G+    + +Y++ E    G+L   L    + H     +    +   
Sbjct: 534 VMTTLEHENLVKFIGLVFHDKYIYLVTEYMSKGSLVDYLRSRGRQHITRRDQINFAFDTC 593

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQV 261
           +G+ Y+  K ++HRD+AARN L     V
Sbjct: 594 SGMEYLEMKKVIHRDLAARNVLISEECV 621


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  262 bits (670), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 79/273 (28%), Positives = 135/273 (49%), Gaps = 34/273 (12%)

Query: 10  KYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
            +Y+G + R   +++L    NK G FL+R SE       ++ +S   E K    HF ++ 
Sbjct: 249 PWYYGNINRVKAEKLLLASQNKDGSFLVRISES---HSDEYTISARSEGK--VFHFRIQR 303

Query: 66  SDHKVYV--DKIGFPTIIELVNHYVSTKESF-------STKDGTVKAVL----KQAVERQ 112
           S    Y   D+I F T+ EL+++Y     S          +   +   L    ++  + +
Sbjct: 304 SSIGAYFVSDRISFATLGELISYYQRNNRSLGVLLEEPCAQQRPLTPSLLCLQRELFDME 363

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            WE   E+  L +KLGEG FGEVW+         + +   VA+KT K E   ++   E +
Sbjct: 364 PWERPREEFRLLRKLGEGHFGEVWEALW------STENRRVAIKTLKQEDTKQD---EFV 414

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIY-- 230
           +E + +++L H  +++   + +  EP+Y++ EL   G+L + L      ++    LIY  
Sbjct: 415 KEVQALKSLHHPKLIQLLAMCSRGEPVYIVTELMTKGSLKAYLASAEGQVLTSAHLIYMG 474

Query: 231 -QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            Q A G+AY+ ++N++HRD+AARN L G   V 
Sbjct: 475 SQIAEGMAYLEDRNIVHRDLAARNILVGEDLVC 507



 Score =  211 bits (539), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 68/248 (27%), Positives = 116/248 (46%), Gaps = 25/248 (10%)

Query: 26  NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESD-HKVYVD-KIGFPTIIEL 83
           N  G FL+R SE    +   +VLSV         H+ V ++D ++ YV+    F ++ EL
Sbjct: 733 NSEGAFLIRVSEK---DNVGYVLSV--RSGDQVKHYKVLQTDQNRFYVEPGRRFSSLAEL 787

Query: 84  VNHYVSTKE------SFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWK 137
           V++Y  T            K  T+            WEL  ++ EL ++LG G F  V++
Sbjct: 788 VDYYQKTSLNNAGPLGNPCKRNTLSTPALLPFPTIGWELPKKEFELEEELGSGCFARVYR 847

Query: 138 GKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE 197
           G+   +       + VAVK  K +S       +   E ++++NL H +++  F V   + 
Sbjct: 848 GRWKNL-------IRVAVKILKSDSELNHG--DFQTEVQILKNLRHRHLLSLFAVCTESR 898

Query: 198 PLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNC 254
           P ++I EL + G+L   L      +  +    ++  Q A+G++Y+ E+  +HRD+AARN 
Sbjct: 899 PYWIITELMEKGSLLIFLRSPEGQNQDVASLIDMGTQVADGMSYLEEQKSIHRDLAARNV 958

Query: 255 LYGGGQVL 262
           L G     
Sbjct: 959 LVGEDYTC 966



 Score =  112 bits (282), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 47/169 (27%), Positives = 75/169 (44%), Gaps = 24/169 (14%)

Query: 9   QKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVR 64
           Q ++ G L R   Q  L    N  G FL+R SE    +   +VLSV         H+ V 
Sbjct: 67  QPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEK---DNVGYVLSV--RSGDQVKHYKVL 121

Query: 65  ESD-HKVYVD-KIGFPTIIELVNHYVSTKE------SFSTKDGTVKAVLKQAVERQKWEL 116
           ++D ++ YV+    F ++ ELV++Y  T            K  T+            WEL
Sbjct: 122 QTDQNRFYVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLSTPALLPFPTIGWEL 181

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTK 165
             ++ EL ++LG G F  V++G+   +       + VAVK  K  +++K
Sbjct: 182 PKKEFELEEELGSGCFARVYRGRWKNL-------IRVAVKILKSAAVSK 223


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score =  260 bits (666), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 79/274 (28%), Positives = 124/274 (45%), Gaps = 26/274 (9%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKT 56
           +    +  Q ++ G + R      L    N  G FL+R SE    +   +VLSV    K 
Sbjct: 124 LARDSVESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSES---DDMGYVLSV--RTKE 178

Query: 57  SANHFVVRESDHKVYVDKI-GFPTIIELVNHYVSTK----ESFSTKDGTVKAVLKQAVER 111
           +A HF + ++  + YVD +  F +I+E++ HY S      +  S     +K         
Sbjct: 179 NAKHFKIFQTGDQFYVDALFKFSSIVEVIEHYQSHPLSIGDLLSEPCIRIKPENVPPPST 238

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WEL  E+ +L  +LG G F +V+ GK             VA+K  K        ++E 
Sbjct: 239 DEWELPKEEFQLENQLGSGHFADVYSGKWKNHSK-------VAIKILKNNDAL--VLREF 289

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYEL 228
             E ++M+ L H +++  F V   + P Y+I EL + G L   L         M    ++
Sbjct: 290 QLEVQIMKRLRHKHLISLFAVCTSSSPFYIITELIEKGDLLHFLRNPEGRSLQMESLIDM 349

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G+AY+   N +HRD+AARN L G G V 
Sbjct: 350 AAQVADGMAYLEANNSIHRDLAARNVLVGDGYVC 383


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score =  260 bits (666), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 77/272 (28%), Positives = 122/272 (44%), Gaps = 27/272 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSV--VGEKKTS 57
           + L  ++++     R++ +  L    NK G FL+R SE  KG    F LSV  V  +   
Sbjct: 117 ESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGA---FSLSVKDVTTQGEL 173

Query: 58  ANHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKD--GTVKAVLKQAVERQK 113
             H+ +R  D   Y    +I FP++  LV HY    +    +     V+   +    + +
Sbjct: 174 IKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDE 233

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+  + + L +KLG G FGEVW G            + VA+KT K  +M+ E     + 
Sbjct: 234 WEIPRQSLRLVRKLGSGQFGEVWMGYYKNN-------MKVAIKTLKEGTMSPEA---FLG 283

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIY 230
           EA +M+ L H  +V+ + V    EP+Y++ E    G L   L         + +  ++  
Sbjct: 284 EANVMKALQHERLVRLYAVVT-KEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSA 342

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q A G+AYI   N +HRD+ A N L       
Sbjct: 343 QIAEGMAYIERMNSIHRDLRAANILVSEALCC 374


>UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax=Coelomata
           RepID=BMX_HUMAN
          Length = 675

 Score =  260 bits (665), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 74/271 (27%), Positives = 123/271 (45%), Gaps = 23/271 (8%)

Query: 5   DLLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           +L    ++ G + R   +++L    K G F++R S  V           V +KK +  H+
Sbjct: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHY 349

Query: 62  VVRES-DHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK------ 113
            V  + ++K+Y+ +   F +I +L++++        T+     +     V          
Sbjct: 350 HVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGI 409

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WEL  E++ L K+LG G FG V  GK     D       VAVK  K  SM+++   E  +
Sbjct: 410 WELKREEITLLKELGSGQFGVVQLGKWKGQYD-------VAVKMIKEGSMSED---EFFQ 459

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQ 231
           EA+ M  L H  +VKF+GV +   P+Y++ E    G L + L          +  E+ Y 
Sbjct: 460 EAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYD 519

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              G+A++     +HRD+AARNCL      +
Sbjct: 520 VCEGMAFLESHQFIHRDLAARNCLVDRDLCV 550


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score =  259 bits (662), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 76/271 (28%), Positives = 130/271 (47%), Gaps = 27/271 (9%)

Query: 6   LLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    ++ G + RE  +E+L   + G FL+R S    G+    V+S    KK   ++ V+
Sbjct: 87  LHEMPWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVE-HYRVI 145

Query: 64  RESDHKVYVDKIGF-PTIIELVNHYVSTKESFST---------KDGTVKAVLKQAVERQK 113
             SD++V VD+  F PT+IEL+ HY    +   T          +    A+ K++ +++ 
Sbjct: 146 STSDNQVTVDEEAFFPTLIELIKHYEKDADGLCTMLKKPLKKKTEILQSAIFKESFQKEG 205

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           W +  EDVE  + +G+G FG V+KG   K          VA+K  + +S T +    ++ 
Sbjct: 206 WAVPIEDVEFKELIGKGEFGNVYKGVWAKK--------TVAIKKLRDDSKTAQS---LLA 254

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIY 230
           EA +M  L H N+V    ++   + + ++ E  + G L   L    +    + ++     
Sbjct: 255 EASVMTTLQHKNLVVLVAISFQGDSILILTEYCEKGVLVEYLRTRGRAVITLEEQKGFAI 314

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
              NG+ Y+ EKN++HRD+AARN L      
Sbjct: 315 DVCNGMRYLEEKNIIHRDLAARNVLLSDELC 345


>UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera RepID=SRC64_DROME
          Length = 552

 Score =  258 bits (661), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 70/277 (25%), Positives = 121/277 (43%), Gaps = 31/277 (11%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVG---EKK 55
           ++ +  + ++   + R++  ++L    N  G FL+R SE        + LSV      + 
Sbjct: 154 ERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPN---GYSLSVKDWEDGRG 210

Query: 56  TSANHFVVRESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ------ 107
               H+ ++  D+  Y       FP++  LV  Y                  +       
Sbjct: 211 YHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCPKPQPQMWDLG 270

Query: 108 AVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
              R K+E+   +++L +KLG G FGEV+ GK    +D       VAVKT +  +M+   
Sbjct: 271 PELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSID-------VAVKTLREGTMSTAA 323

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIK 224
               ++EA +M+   H  +V  + V +  EP+Y++ E    G+L   L +    +     
Sbjct: 324 ---FLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFED 380

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
              +  Q A+G+ Y+  K L+HRD+AARN L G   V
Sbjct: 381 LIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNV 417


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  256 bits (656), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 77/269 (28%), Positives = 131/269 (48%), Gaps = 27/269 (10%)

Query: 5   DLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVV--GEKKTSANH 60
           DL ++ ++HG + R + + +L   +PG FL+R SE +KG    + L+++   +     +H
Sbjct: 62  DLTNEPWFHGNIGRIEAENLLQYSEPGTFLIRESETIKG---SYTLTMIQIKDGTKQISH 118

Query: 61  FVVRESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK---WEL 116
           F +   D K ++     F  + +L+ HY+   +  +     V    K ++E  +   WE+
Sbjct: 119 FRINYDDGKYFITSARRFLGLHQLIQHYMQNSDGLACN--LVYPQPKPSIEYMELDVWEI 176

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
               ++L  KLG G FG+VWKG L            VA+K  ++ +MT E     + EA+
Sbjct: 177 DRGRLKLETKLGSGGFGDVWKGTLDGSF-------TVAIKQLQIGTMTTEA---FLEEAK 226

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKYELIYQAA 233
            M+ L H  +VK   V   TEP+Y++ E    G L S L +       +    ++  Q A
Sbjct: 227 AMKQLQHDKLVKLHAVVP-TEPVYIVSEFMCNGDLLSYLKRKGSYDLQLGDLLDMAAQVA 285

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +G+A+I   N +HRD+ A N L G  +  
Sbjct: 286 SGMAFIEANNYIHRDLRAANILVGENKEC 314


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score =  256 bits (655), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 69/271 (25%), Positives = 120/271 (44%), Gaps = 28/271 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    ++HG + RED +++L   K G+FL+R S+   G+   + L V  + +    ++ V
Sbjct: 104 LKTMPWFHGRISREDAEKLLTPPKNGRFLVRESQNYPGD---YTLCVSYDGRVE--NYRV 158

Query: 64  RESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVK--------AVLKQAVERQK 113
           R ++  +    D   F  +I+LV HY    +   T+              V     + + 
Sbjct: 159 RRNEKGLVTVDDDEYFDNLIKLVEHYQKEADGLCTRLKAPVDKEGQHLFVVDVNDFKEKG 218

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           W +    +     +G+G FGEVW G        +++   VA+K+ K     ++   + + 
Sbjct: 219 WAIPKASLLKKSLIGKGEFGEVWLG--------DYEGKKVAMKSMKDHLKDEKAKTQFLA 270

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK---YELIY 230
           EA +M  L H N+V   G++    P+Y+I E    G+L   L      +I K    +   
Sbjct: 271 EASVMTTLRHPNLVCLIGISLDDNPIYLITEFMAKGSLIDYLRSRGRAVITKQNQIDFAR 330

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
               G+ Y+  +N +HRD+AARN L     V
Sbjct: 331 DVVKGMVYLESQNFVHRDLAARNVLIAEDNV 361


>UniRef50_Q22765 Protein T25B9.4, partially confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=Q22765_CAEEL
          Length = 546

 Score =  255 bits (653), Expect = 9e-67,   Method: Composition-based stats.
 Identities = 94/274 (34%), Positives = 155/274 (56%), Gaps = 21/274 (7%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKG--EKRQFVLSVVGEKKT--- 56
           T K L++QK+YHG LPRED+  +L K G F+ R +E   G  +K+  VLS+    ++   
Sbjct: 7   TFKWLMNQKFYHGYLPREDLPYVLKKKGDFIFRVTERTVGKEQKKDIVLSIAWPTESVAM 66

Query: 57  ----SANHFVVRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER 111
                  ++++  S + V++D KI F +I  L NHY   +         ++  L + +  
Sbjct: 67  IDTKDIKNYLIERSANSVWLDLKISFHSIDALYNHYRKNELVHP----NLRIKLGRPICL 122

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLE-SMTKEQIKE 170
             WE  H  + L KK+G+GA+GEV+KG + +     +     A+K  + +     E++KE
Sbjct: 123 FFWEFKHSQINLIKKVGKGAYGEVFKGTVTRGNKTFNG----AIKAMRKDLDAGNEKMKE 178

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYEL 228
           +M EARLMR+L+H N+V+  G+A   +P+Y+++E  +GG LDS L K      M +K  +
Sbjct: 179 VMAEARLMRSLNHPNIVRCRGIAVLEQPVYIVIEFINGGGLDSYLKKNSQTLTMDQKNRM 238

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              AA G+ ++H  +++HRD+AARNCLY    ++
Sbjct: 239 AISAAWGIEFMHSHDIIHRDIAARNCLYDNKNLV 272


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score =  254 bits (650), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 75/273 (27%), Positives = 123/273 (45%), Gaps = 28/273 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
             L  + ++ G   R +    L       G FL+R SE   G     V         +  
Sbjct: 106 NSLEVEGWFFGSCTRSEAIMRLQADNLPKGTFLVRESETRPGTYALTVRETDHGHPPTIK 165

Query: 60  HFVVRESDHK---VYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA-----VE 110
           ++ V ++       +++ +  F T+I++V  + S      +K   +K   KQ      + 
Sbjct: 166 NYRVDKTKDGSELFFINPQRKFNTVIDVVKFHTSQPGGLCSK--LLKPCPKQTPNTRTLG 223

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
            + WEL    ++L  KLG+G FG VWKG            V VAVKT +  +M+ E    
Sbjct: 224 HEVWELPRSSLKLLDKLGQGQFGAVWKGIYDG-------KVEVAVKTLRPGTMSPEA--- 273

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYE 227
            + EA LM+ L H+ +V  +G+ +  EP+Y+I EL   G+L   L +    +  + +  +
Sbjct: 274 FLAEANLMKELKHVKLVNLYGICSDEEPIYIITELMVNGSLLGYLREGGGQYLGLRELVD 333

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
           +  Q A G+ Y+  K  +HRD+AARN L G   
Sbjct: 334 IAAQIARGMNYLESKGYVHRDLAARNVLIGLNN 366


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score =  254 bits (649), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 70/274 (25%), Positives = 115/274 (41%), Gaps = 23/274 (8%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
            +  +   ++Y   + R   +++L    K G F++R S               G+ +   
Sbjct: 272 AEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVI 331

Query: 59  NHFVVRESDHKVYV--DKIGFPTIIELVNHYVSTKESF------STKDGTVKAVLKQAVE 110
            H+VV  +    Y   +K  F TI EL+N++                     A     + 
Sbjct: 332 RHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG 391

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
              WE+  +D+   K+LG G FG V  GK     D       VA+K  K  SM+++   E
Sbjct: 392 YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD-------VAIKMIKEGSMSED---E 441

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYEL 228
            + EA++M NL H  +V+ +GV     P+++I E    G L + L   +  F   +  E+
Sbjct: 442 FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEM 501

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                  + Y+  K  +HRD+AARNCL     V+
Sbjct: 502 CKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVV 535


>UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186E29F
          Length = 466

 Score =  253 bits (646), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 72/250 (28%), Positives = 123/250 (49%), Gaps = 31/250 (12%)

Query: 19  EDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDK 74
            D ++ L    N+ G FL+R SE  + +   + LSV      +  H+ +      ++  K
Sbjct: 109 SDSEKKLLLPENEHGAFLIRDSESRRND---YSLSV--RDGDTVKHYRIDIRRRWIFCSK 163

Query: 75  IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGE 134
             F T+ ELV H         T +  V   L  +  R +WE+  + ++  +KLG G FG+
Sbjct: 164 NNFRTLQELVEH---------TIEKPVTGGLSHST-RDQWEIDRKSLKFVRKLGHGQFGD 213

Query: 135 VWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAA 194
           VW+G         +    VA+KT K  +M     K+ + EA++M+ L H  +++ + V  
Sbjct: 214 VWEGLW-------NNTTPVAIKTLKPGTMDP---KDFLAEAQIMKKLRHQKLIQLYAVCT 263

Query: 195 GTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAAR 252
             EP+Y+I EL   G+L   L        + +  ++  Q A+G+A++  +N +HRD+AAR
Sbjct: 264 MEEPIYIITELMKNGSLLEYLQGKGRQLKLAQLVDMAAQIASGMAFLESQNYIHRDLAAR 323

Query: 253 NCLYGGGQVL 262
           N L G G ++
Sbjct: 324 NVLVGDGNIV 333


>UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein tyrosine kinase n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E4736E
          Length = 387

 Score =  252 bits (645), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 76/269 (28%), Positives = 122/269 (45%), Gaps = 32/269 (11%)

Query: 11  YYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGE---KKTSANHFVV 63
           +  G+  R+D ++ L       GQF++R       +   F LSV      K     H+ +
Sbjct: 7   WDFGMCSRQDAEKKLMAIGINKGQFIVR-----DRDPGTFELSVRDNNPQKGDHVKHYRI 61

Query: 64  RESDHK---VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ---AVERQKWELY 117
            + D            FPT+ ELV HY    +    K              + + KWE  
Sbjct: 62  WKMDGGNSFFIFQGSVFPTVSELVRHYQMNSDGLCCKLTEACPKENPNTIGLGKDKWETP 121

Query: 118 HEDV-ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
            + + ++ ++LGEG FGEVW+G         +    VAVKT K  +M+       + EA 
Sbjct: 122 RKSLGQMNRRLGEGKFGEVWQGVW-------NGNTPVAVKTLKERTMSPAA---FLAEAN 171

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAA 233
           +M+ L H  +V+ + V +  EP+Y++ EL   G L + L      +  M    ++    A
Sbjct: 172 VMKKLRHEGIVQLYAVCSDKEPIYIVTELMSNGDLRTYLKSDKCKNTKMTTLIDMGAHIA 231

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +G+ Y+  KN++HRD+AARN L G G V+
Sbjct: 232 SGMDYLGSKNVVHRDLAARNVLVGKGNVV 260


>UniRef50_A8PJL3 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8PJL3_BRUMA
          Length = 668

 Score =  252 bits (645), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 108/254 (42%), Positives = 145/254 (57%), Gaps = 11/254 (4%)

Query: 11  YYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN-HFVVRESDHK 69
           Y+HG LPRED   +    G FLLRT+E   GE R+  LSV    K     H+  +  +  
Sbjct: 243 YFHGFLPREDANMLCILDGDFLLRTTEVFSGEDRKLCLSVAWHGKHHIILHYD-KLKNRY 301

Query: 70  VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
                  FPTI +LVN+Y   +     +    + +LK  +  Q WEL H+ ++L +KLGE
Sbjct: 302 GIKPSRTFPTITDLVNYYAQHRFKILKE----RVLLKNPIVTQSWELKHQQLQLLQKLGE 357

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           GAFGEV    L      +   V  AVK  K ++MTKE+++E M E R++RNL H N+V+F
Sbjct: 358 GAFGEVHSANLALTPRFH---VKAAVKVLKCDAMTKEKVREAMCEVRMLRNLRHENIVRF 414

Query: 190 FGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELIYQAANGLAYIHEKNLMHR 247
           +GVA   EPL ++MEL   GALD  L K   +  M  K  +I  AA GLAY+H +N+MHR
Sbjct: 415 YGVANRKEPLMIVMELVKEGALDVFLRKNGNNLSMKNKLLMIRDAAFGLAYLHSQNIMHR 474

Query: 248 DVAARNCLYGGGQV 261
           D+A RNCLY G  V
Sbjct: 475 DLATRNCLYTGEIV 488


>UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata RepID=TEC_HUMAN
          Length = 631

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 65/274 (23%), Positives = 118/274 (43%), Gaps = 25/274 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
            +L   ++Y   + R   +++L    K G F++R S               GE  +   H
Sbjct: 240 NNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRH 299

Query: 61  FVVRES---DHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGT------VKAVLKQAVE 110
           + ++E+     K Y+ +K  F +I E++ ++        T+           A       
Sbjct: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
            +KWE+   ++   ++LG G FG V  GK             VA+K  +  +M +E   +
Sbjct: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYK-------VAIKAIREGAMCEE---D 409

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYEL 228
            + EA++M  L H  +V+ +GV    +P+Y++ E  + G L + L +   HF       +
Sbjct: 410 FIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSM 469

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                 G+ Y+   + +HRD+AARNCL     V+
Sbjct: 470 CQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVV 503


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 68/269 (25%), Positives = 116/269 (43%), Gaps = 29/269 (10%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNKP--GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
            L    ++HG + RE  + +L  P  G FL+R S    G+   + L V  + K    H+ 
Sbjct: 76  KLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGD---YTLCVSCDGKVE--HYR 130

Query: 63  VRESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAV-----LKQAVERQKWEL 116
           +     K+ +D+ + F  +++LV HY S  +   T+    K +      +    R  W L
Sbjct: 131 IMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWAL 190

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
             ++++L + +G+G FG+V  G              VAVK  K ++      +  + EA 
Sbjct: 191 NMKELKLLQTIGKGEFGDVMLGDYRGN--------KVAVKCIKNDATA----QAFLAEAS 238

Query: 177 LMRNLDHINVVKFFGVAAGTEP-LYVIMELADGGALDSALGKLHFPMI---KKYELIYQA 232
           +M  L H N+V+  GV    +  LY++ E    G+L   L      ++      +     
Sbjct: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
              + Y+   N +HRD+AARN L     V
Sbjct: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNV 327


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score =  250 bits (638), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 74/277 (26%), Positives = 121/277 (43%), Gaps = 34/277 (12%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           +  L    ++HG + R D +++L   K G FL+R S    G+   + + V         H
Sbjct: 100 EVKLTAMPWFHGKITRSDAEDLLTPRKDGLFLVRESTNYPGD---YTMCVSFAG--EVEH 154

Query: 61  FVVRESDHKVYVDKI-GFPTIIELVNHYVSTKESFST--------KDGTVKAVLKQAVER 111
           + V   D+KV +D+   F  + +LV HY    +            K G   +V  +   +
Sbjct: 155 YRVIFKDNKVTIDEEEYFENLTKLVEHYERDADGLVCTLTQPLIKKGGHEYSVDTEEFRK 214

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             W +   D++L   LG+G FG+V++G          +   VAVK+ K  S   +     
Sbjct: 215 SGWAINFTDLKLGTILGKGDFGDVYEGTY--------KDQKVAVKSVKDRSKAAQA---F 263

Query: 172 MREARLMRNLDHINVVKFFGVA----AGTEPLYVIMELADGGALDSALG---KLHFPMIK 224
           + EA +M  L H N++K  GV        +P+YV++E    GA+   L    +       
Sbjct: 264 LAEASVMTQLHHKNLIKLLGVVIPQTMSNDPIYVVLEFMTKGAMLEYLRSRGRALVTSND 323

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
            ++     A G+ Y+  K L+HRD+AARN L     V
Sbjct: 324 LWKFAKDIALGMEYLENKQLVHRDLAARNILISEECV 360


>UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosine kinase 6 n=1 Tax=Danio
           rerio RepID=UPI000175FB8C
          Length = 510

 Score =  249 bits (637), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 79/274 (28%), Positives = 134/274 (48%), Gaps = 29/274 (10%)

Query: 5   DLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVV-GEKKTSAN 59
            +  Q +Y G L R + + +L    N  G FL+R SE    +   +VLSV+ G++     
Sbjct: 117 TVKEQPWYFGTLNRFETEILLLAPENDVGAFLVRHSEK---DNIGYVLSVLSGDRSREVK 173

Query: 60  HFVVRES-DHKVYVDK-IGFPTIIELVNHYVS---TKESFSTKDGTVKAVLKQAVER--- 111
           H  + ++ +   Y+DK   F ++ +LV++Y       +SF  +         + +     
Sbjct: 174 HIKIHQNQNESFYLDKSQTFQSLEKLVDYYWKYSLDGDSFLKQPCRRPEPKPKDLSHSTV 233

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             WEL  E+  L ++LG+G F +V++GK   +       V VA+K  K +S+     +E 
Sbjct: 234 NDWELPKEEFTLEEELGKGFFADVYRGKWKGM-------VNVAIKILKNDSINH---REF 283

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYEL 228
           M E ++++ L H +++  F V   + P Y+I EL + G L S L              E+
Sbjct: 284 MLETQILKKLRHKHLIALFAVCTSSSPFYIITELMEKGDLLSLLKGKEGQDLNAQMLTEM 343

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G+AY+ E+N +HRD+AARN L G   + 
Sbjct: 344 ASQVADGMAYLEEQNSIHRDLAARNVLVGANYIC 377


>UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RNL0_TETNG
          Length = 509

 Score =  249 bits (637), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 81/297 (27%), Positives = 125/297 (42%), Gaps = 68/297 (22%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQ-------------- 45
             +  +++Y G + R+D +  L    N+ G FL+R SE  KGE                 
Sbjct: 61  DSIQAEEWYFGKMGRKDAERQLLAHGNQRGTFLIRESETTKGEHSHAHTLRQLPGRGLYV 120

Query: 46  --------------FVLSVV---GEKKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYV 88
                         + LS+      K     H+ +R+ D+  Y               Y+
Sbjct: 121 GYTSVPLHSRFPGAYSLSIRDWDDNKGDHVKHYKIRKLDNGGY---------------YI 165

Query: 89  STKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANH 148
           +T    S K G  K        +  WE+  E ++L KKLG G FGEVW G         +
Sbjct: 166 TT----SCKRGMPKLADLSVKTKDMWEIPRESLQLIKKLGNGQFGEVWMGMW-------N 214

Query: 149 QPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADG 208
               VAVKT K  +M+ E     + EA++M+ L H  +V+ + V +  EP+Y+I E    
Sbjct: 215 GTTKVAVKTLKPGTMSPEA---FLEEAQIMKRLRHDKLVQLYAVVS-EEPIYIITEFMSQ 270

Query: 209 GALDSALGK---LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           G+L   L      +  + +  ++  Q A+G+AYI   N +HRD+ A N L G   V 
Sbjct: 271 GSLLDFLKDGEGQNLKLPQLVDMAAQIASGMAYIERMNYIHRDLRAANILVGDNLVC 327


>UniRef50_A8Q767 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q767_BRUMA
          Length = 500

 Score =  249 bits (636), Expect = 9e-65,   Method: Composition-based stats.
 Identities = 103/275 (37%), Positives = 149/275 (54%), Gaps = 20/275 (7%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS---AN 59
            K +L + YYHG LPRED+  +L + G F++R ++    +  + +LS+    + S     
Sbjct: 19  PKKVLDESYYHGFLPREDLPCLLEQVGDFIIRITQLKPRDPCELILSLRVSDQNSPSAIR 78

Query: 60  HFVVRESDHK------VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK 113
           H V+     K      +   +  F ++ EL++ YVS+K+          + L + + RQ 
Sbjct: 79  HVVIHRLKGKDGKIEWLTNQENRFNSLKELIDAYVSSKKPI--NPEIKTSQLIRPIARQS 136

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAV-KTAKLESM---TKEQIK 169
           WE  HE++ L   LGEG FGEV  G+   I+D    PV V + KT K +      KE+IK
Sbjct: 137 WEFLHENIILKDMLGEGQFGEVRAGEA--IIDGKKIPVAVKIAKTIKDKKNIQQAKEKIK 194

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYE 227
           E+M EARLMR  DH NVVK  GVA   EPL +I+EL +GG L   L   K +    +K E
Sbjct: 195 EMMHEARLMRYFDHENVVKIHGVAVCREPLMIIIELVNGGCLSDVLESRKGNIDEDEKIE 254

Query: 228 -LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
            +   +A GL YIH + ++HRD+AARN LY   +V
Sbjct: 255 NMSLGSARGLEYIHAQRIIHRDIAARNVLYTENRV 289


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 68/271 (25%), Positives = 126/271 (46%), Gaps = 25/271 (9%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPG----QFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
            + +  + ++ G + R +    L   G     FL+R SE    +   +VLSV      + 
Sbjct: 70  RETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSAD---YVLSV--RDTQAV 124

Query: 59  NHFVV-RESDHKVYV-DKIGFPTIIELVNHY--VSTKESFSTKDGTVKAVLKQAVERQKW 114
            H+ + R +  ++++ + + F ++ ELVN++   S            K   +       W
Sbjct: 125 RHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDW 184

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E   E+  L +KLG G FGEV++G            V VA+K    +++  +Q+  +  E
Sbjct: 185 ERPREEFTLCRKLGSGYFGEVFEGLW-------KDRVQVAIKVISRDNLLHQQM--LQSE 235

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIYQ 231
            + M+ L H +++  + V +  +P+Y+I EL   G+L   L        P+ +  ++ +Q
Sbjct: 236 IQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQ 295

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            A G+ Y+  +N +HRD+AARN L G   + 
Sbjct: 296 VAEGMCYLESQNYIHRDLAARNILVGENTLC 326


>UniRef50_P91360 Putative uncharacterized protein n=3 Tax=root RepID=P91360_CAEEL
          Length = 577

 Score =  248 bits (634), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 99/294 (33%), Positives = 154/294 (52%), Gaps = 41/294 (13%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTS--------------------EPVKGE 42
           +  +     +HG + RED  ++L  PG +L+R S                    E  KG 
Sbjct: 164 EDYITKMPNFHGYICREDAAQILKHPGDWLVRLSVPPSNDQDKKNKAQNLAKSVERTKGH 223

Query: 43  KRQ----FVLSVVGEKK------TSANHFVVRESDHKVYVDKIGFP-TIIELVNHYVSTK 91
           K      FV+SV+ + K      ++  + V++ ++ K  +D + +   + +L +HY  T 
Sbjct: 224 KSTMQKVFVISVLCKGKALSPAKSNNRNLVIKTNNGKFSIDSVHWLVKLKDLFSHYQGT- 282

Query: 92  ESFSTKDGTVKAVLKQAVERQKWELYHEDVELT-KKLGEGAFGEVWKGKLLKILDANHQP 150
            S   K+G  +  L   +   KWE  HED EL  KKLGEGAFGEV  G+L    D   + 
Sbjct: 283 -SAVHKNGEFQ--LLNPISLSKWEFQHEDTELLAKKLGEGAFGEVRVGRLT-TKDPKKKL 338

Query: 151 VLVAVKTAKL--ESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADG 208
           V VAVK  K   +S+T++Q++E++ E R+MR LDH NV++ +GVA   EPLY+++EL   
Sbjct: 339 VEVAVKMLKSSADSVTRDQVEELLHETRIMRKLDHPNVLRSYGVAVLREPLYLMIELCSN 398

Query: 209 GALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
           GAL   L + H    +  K   +  +A G+AY+H + ++HRD+A RN L    +
Sbjct: 399 GALREYLKENHKTITLADKINFVLGSARGVAYLHSQRILHRDLAVRNILLTEDK 452


>UniRef50_A8NEQ9 Protein kinase domain containing protein (Fragment) n=1 Tax=Brugia
           malayi RepID=A8NEQ9_BRUMA
          Length = 293

 Score =  248 bits (634), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 101/205 (49%), Positives = 139/205 (67%), Gaps = 7/205 (3%)

Query: 58  ANHFVVRES-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL 116
             H+V++ + + K  ++K GF ++ E++N +++  ES        +  L   + RQ WEL
Sbjct: 1   IKHYVIQRTPNGKYTIEKYGFDSVPEMINFHLNKHESLVKN---AEVFLTTPILRQTWEL 57

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
           +HEDVE TKKLGEGAFGEV  G+L      N + V VA+K AKLE++TKEQIKEIM+EAR
Sbjct: 58  HHEDVEPTKKLGEGAFGEVHLGRLRL---RNGRKVDVAIKLAKLEALTKEQIKEIMKEAR 114

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGL 236
           L R  DH NV K +GVAAG EPL ++MELA+ GALDS L K H  + +K ++   A+ GL
Sbjct: 115 LHRTFDHPNVCKCYGVAAGQEPLMIVMELANKGALDSYLQKNHVSVEQKMDMCLGASWGL 174

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQV 261
            Y+H K ++HRD+AARNCL+G  +V
Sbjct: 175 EYLHAKPVLHRDIAARNCLFGDNKV 199


>UniRef50_Q19726 Protein F22D6.1, partially confirmed by transcript evidence n=5
           Tax=root RepID=Q19726_CAEEL
          Length = 418

 Score =  246 bits (629), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 87/264 (32%), Positives = 136/264 (51%), Gaps = 24/264 (9%)

Query: 7   LHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
            + +++HG+L R+D  E+L KPG FLLR SE     K   +LSV  + K   N  V  ++
Sbjct: 26  QNNEWFHGVLQRQDADELLVKPGSFLLRASEVHG--KMSMILSVRHDGKLH-NIAVNSDT 82

Query: 67  DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKK 126
               + +     +I +LV  +++T    +   G     LK  + +  W + HE+V   KK
Sbjct: 83  GENFWFEGHREKSIDQLVQWHMTTSTPITKTSG---VKLKYPIGKADWIISHENVIFIKK 139

Query: 127 LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINV 186
           LGEGAFGEV   +     +   + V  AVKT + + MT++     M+EARLMR   H ++
Sbjct: 140 LGEGAFGEVSLAEC----EIGGRKVETAVKTMRCQ-MTRDTRAAFMKEARLMRKYSHPHI 194

Query: 187 VKFFG-----------VAAGTEPLYVIMELADGGALDSALGKLHF--PMIKKYELIYQAA 233
           V+  G           +A    PL ++ME+   G+L S L K      + ++     ++A
Sbjct: 195 VRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHGSLLSFLRKNKGKTTLSERLRFCIESA 254

Query: 234 NGLAYIHEKNLMHRDVAARNCLYG 257
           +GLAY+ +K  +HRD+AARNCL  
Sbjct: 255 DGLAYLEKKQCLHRDIAARNCLLS 278


>UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia malayi
           RepID=A8Q5B5_BRUMA
          Length = 1138

 Score =  244 bits (623), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 86/272 (31%), Positives = 135/272 (49%), Gaps = 21/272 (7%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             K+L  Q +YHGLL REDI+++L K G FL+R ++       Q VLS+         H 
Sbjct: 714 QRKELEDQHWYHGLLSREDIEKLLVKNGDFLVRVTDNQG--VHQIVLSI--HVGERNIHL 769

Query: 62  VVRESDHKVYV-----DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL 116
            +  ++   +          FP+I +LV +Y   K       G     L   V + KW +
Sbjct: 770 TIAVTEDGHFQLSVLRRGPRFPSIYDLVQYYKMHKIKIKDASGK-DIRLGDGVPKPKWLV 828

Query: 117 YHEDVELTK--------KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLE-SMTKEQ 167
            HE +   K         LG G F +V+ G      D N Q + VA+K  K E    +E 
Sbjct: 829 KHEAINYDKNKACHLNLPLGSGNFADVYLGTFTCEKDGNKQIIPVAIKIIKPEKGGGREA 888

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI--KK 225
            + ++RE ++M   +H N+V+F+GVA    P+ ++ME   GG+L++ L K    ++  ++
Sbjct: 889 KQSMIREGKIMSFYNHENIVQFYGVACDRPPIAIVMEYCPGGSLENHLKKQKENIVIGER 948

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
            E   +AA G+ Y+H +  +HRD+AARNCL  
Sbjct: 949 IEYCLEAALGMRYLHMQGCLHRDLAARNCLIS 980


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score =  243 bits (620), Expect = 6e-63,   Method: Composition-based stats.
 Identities = 82/271 (30%), Positives = 135/271 (49%), Gaps = 27/271 (9%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS 57
           + + L  Q +Y   + R   Q++L    N+PG FL+R SE   G    + LSV  + K  
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLG---GYSLSVRAQAKVC 167

Query: 58  ANHFVVR-ESDHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-W 114
             H+ V   +D  +Y+ K   FP + EL+ +Y +  +    ++  ++  + Q   RQ  W
Sbjct: 168 --HYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLI--QNPLLQPCMPQKAPRQDVW 223

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E  H +  L +KLGEG FGEVW+G  L  L        VA+K  K  +M   ++ ++ +E
Sbjct: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLGSL-------PVAIKVIKSANM---KLTDLAKE 273

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIYQ 231
            + ++ L H  +++   V +G EP+Y++ EL   G L + LG        +        Q
Sbjct: 274 IQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQ 333

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            A G++Y+ E+ ++HRD+AARN L   G   
Sbjct: 334 VAEGMSYLEEQRVVHRDLAARNVLVDDGLAC 364


>UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7QBP3_IXOSC
          Length = 626

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 72/279 (25%), Positives = 125/279 (44%), Gaps = 37/279 (13%)

Query: 6   LLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGEK-KTSANHF 61
           L   ++Y G + R+  +++L    K G F++R S         F LS++      S    
Sbjct: 239 LWQHEWYAGDMSRQRAEQVLRQETKEGAFVVRNSSTQ----GFFTLSLLANSIMNSWASS 294

Query: 62  VVRESDHKVYVDKIGFPTIIELVNHYVS-------------TKESFSTKDGTVKAVLKQA 108
           + +   HK+        T   L NH +S                 +  ++   +      
Sbjct: 295 LFKSLRHKIEATDQYLETSYAL-NHAMSIMVFERRGKDCLFRNSCYYCQNSCCQPDSTNN 353

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
               KWE+   ++ L ++LG G FG V +GK     D       VAVK  K  +M+++  
Sbjct: 354 PSLDKWEIDPSELALLEELGSGQFGVVRRGKWRGCRD-------VAVKMMKEGTMSED-- 404

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK--- 225
            + + EA+LM  L H N+V+ +GV +   P++++ E    G+L   L +    + ++   
Sbjct: 405 -DFIEEAKLMTKLQHPNLVQLYGVCSKHRPIFIVAEYMKHGSLLHFLRRHEKALSERGPL 463

Query: 226 --YELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              ++  Q A+G+AY+   N +HRD+AARNCL G   V+
Sbjct: 464 LLLDVCLQVASGMAYLELHNYIHRDLAARNCLVGENYVV 502


>UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona intestinalis
           RepID=UPI000180C4F3
          Length = 512

 Score =  241 bits (617), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 76/273 (27%), Positives = 123/273 (45%), Gaps = 39/273 (14%)

Query: 11  YYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
           +      R +   +L    N  G FL R       E   + LSV      + NH  + + 
Sbjct: 131 WMFDTADRSEAVSLLMQPCNNHGDFLARRRTTNPNE---YALSV--RNGATVNHIKIEKM 185

Query: 67  DHKVY-VDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER------------Q 112
             + Y +D    F T+ +LV +Y   +E+    D  +++  KQ V               
Sbjct: 186 GGQGYSIDHHTMFATLNDLVGYY---QENMLANDIRLRSPCKQVVMESPQTAGLSHDLAD 242

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVK-TAKLESMTKEQIKEI 171
           +WE+  + +EL +KLG+G FGEV+KG         +    VAVK   K + + KE   E 
Sbjct: 243 EWEIDRKSIELKEKLGKGNFGEVYKGLW-------NGTTRVAVKKMIKSDLLDKE---EF 292

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELI 229
           ++EA++M+ L H  +V+ + V   +EP Y++ EL   G+L   L +           E+ 
Sbjct: 293 LKEAKIMKKLHHPKLVQLYAVCTHSEPFYIVTELMCNGSLREYLREKGKDLNEDTLIEMA 352

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            Q A G+ Y+   + +HRD+AARN L G   + 
Sbjct: 353 IQVATGMVYLEVNDYIHRDLAARNILVGKNNIC 385


>UniRef50_A8Q7I8 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q7I8_BRUMA
          Length = 375

 Score =  241 bits (615), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 84/258 (32%), Positives = 135/258 (52%), Gaps = 24/258 (9%)

Query: 7   LHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
           L + +YHG LP  DI  +L + G F++R +     +K    LS +   K      + + +
Sbjct: 11  LQRTFYHGFLPHADIDPLLKEEGDFVIRKT-----DKDGNHLSKIYNWKI-----IFQSA 60

Query: 67  DHKVYVDKIGF-----PTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDV 121
            +  +     +      T+ +L+N + +T    S       A L   V RQ W L H+++
Sbjct: 61  QNNFFCSCYFYCLQDEKTMHDLINWHKTTGTPISAGS---HAKLVNGVGRQPWLLEHDEI 117

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
           +L +KLGEGAFGEV+  + +++    ++   VAVKT + E+  + ++K  M+EAR+MR  
Sbjct: 118 QLQRKLGEGAFGEVYLAQYVQM----NKITDVAVKTMREEASRQARLK-FMKEARIMRKF 172

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIH 240
            H NVVK  G+     PL ++MEL   G++ S L K        K   + +A+ GLAY+ 
Sbjct: 173 SHPNVVKIMGIVVYENPLMIVMELCPEGSMLSYLRKNVPVNSDLKLRFVTEASAGLAYLE 232

Query: 241 EKNLMHRDVAARNCLYGG 258
            K+ +HRD+AARNCL   
Sbjct: 233 SKHCIHRDIAARNCLLSE 250


>UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californica
           RepID=B6DVV3_APLCA
          Length = 517

 Score =  240 bits (613), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 82/264 (31%), Positives = 121/264 (45%), Gaps = 29/264 (10%)

Query: 9   QKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKK----TSANH 60
           Q ++     R++  +ML    N  G FL+R +     +K  +VLSV    K        H
Sbjct: 125 QDWWF-EFDRKESDKMLLLPGNPRGTFLVREAT----DKSTYVLSVRDNDKASGEPCVKH 179

Query: 61  FVVRESD---HKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
           + VR+ D         K  F T+ +++ HY    +    + G      +  V+ ++ E+ 
Sbjct: 180 YRVRKMDDERGYFISAKKTFKTLFDVIEHYKDNSDGLCCQLGAACPRSRPTVQFRELEIK 239

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
            E +ELT KLG G FGEVWKGKL K+       V VAVKT K  +M+ E     + EA++
Sbjct: 240 REVIELTNKLGAGCFGEVWKGKLRKV-------VEVAVKTLKPGTMSSEA---FLNEAKI 289

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAAN 234
           M  L H  +V+   V +  EP  +I EL   GAL   L              ++  Q A 
Sbjct: 290 MHKLTHAKLVQLMAVVSVQEPFLIITELMVNGALLDYLRSEEGKKLKFDVLIDMNAQVAE 349

Query: 235 GLAYIHEKNLMHRDVAARNCLYGG 258
           G+ Y+   N +HRD+ A N L G 
Sbjct: 350 GMTYLESVNFVHRDLRAANILVGE 373


>UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYY1_SCHMA
          Length = 481

 Score =  240 bits (612), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 67/269 (24%), Positives = 115/269 (42%), Gaps = 34/269 (12%)

Query: 11  YYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS----ANHFV 62
           +Y   + R +    L    N  G +L+R S     E + + LSV             H+ 
Sbjct: 97  WY--NIGRREADRKLLLVGNPKGTYLIRPSS----ETQNYALSVRHYDSEKNMWVVKHYR 150

Query: 63  VR--ESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTK-DGTVKAVLKQAVERQKWELYH 118
           +R  +++   ++  +  FP I +LVN+Y    +    +         +  V+ + +E+  
Sbjct: 151 IRILDNNGGFFISIRTTFPNIQDLVNYYTVHPDGLCCRLSIPCPRAYRPPVQFRDFEINR 210

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           + +   +KLG+G FGEV+  K        +  V VAVK      +        + EARLM
Sbjct: 211 DSITRIRKLGQGTFGEVYLAKW-------NGSVEVAVKM----RLDPTDRSRFIEEARLM 259

Query: 179 RNLDHINVVKFFGVAAG--TEPLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAA 233
               H  +V+  GV      +P+Y+I EL   GAL   L         +    +++ Q A
Sbjct: 260 HAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHKLTLDDLIDIMAQIA 319

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +G++Y+ E N +HRD+ A N L      +
Sbjct: 320 SGMSYLEEMNSVHRDLRAANILVDQDYSV 348


>UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2 Tax=Eumetazoa
           RepID=UPI0001925126
          Length = 914

 Score =  240 bits (612), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 60/269 (22%), Positives = 123/269 (45%), Gaps = 27/269 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             +    +YH  + R++  +++     G FL+R +   K     + LS   +      H+
Sbjct: 540 PRVEKLLWYHADMTRQEADQVMQNTNDGTFLVRNASKPKM----YTLSFSFQG--VVKHY 593

Query: 62  VVRE-SDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA---VERQKWEL 116
            ++  SD+  YV  +  F ++++L+ ++       +T+              +    +++
Sbjct: 594 HIKTDSDNLFYVSQRHSFESVVQLIEYHKLNSAGLATRLRFPYTGTNNPPVLLGYGVFQI 653

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
              ++ + K++G G FG V +              LVAVK  K +SM++    + + EA+
Sbjct: 654 NRNELTIMKQIGTGQFGTVHEALWKNNK-------LVAVKMMKPDSMSEN---DFIEEAK 703

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIYQAA 233
           +M+   H N++  +GV   T PLY+++EL   G+L   L              ++I + +
Sbjct: 704 VMQRFQHRNLITLYGVCT-THPLYIVVELMKNGSLLDYLRNNKQLLEKTQVLIDIILKVS 762

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + + Y+ +   +HRD+AARNCL G   ++
Sbjct: 763 SAMEYLEKNKFIHRDLAARNCLVGENNMI 791


>UniRef50_A8QBK0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QBK0_BRUMA
          Length = 442

 Score =  239 bits (610), Expect = 8e-62,   Method: Composition-based stats.
 Identities = 88/259 (33%), Positives = 139/259 (53%), Gaps = 12/259 (4%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
            + +LL + YYHG++   D++++L + G FL     P + E+   V  V   +   A + 
Sbjct: 63  ANDNLLSETYYHGIVNCVDVEKLLIRDGDFLF--GIPEEDEEESIVWVVRYNRDLWAFNI 120

Query: 62  VVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDV 121
            + E D   +V++  F  I E+V+ Y+ T++       T+  V+K+ V    W + H+ V
Sbjct: 121 GLTEKD-LYFVNQKCFKKISEMVSDYIRTRKPIHE---TLPIVVKRPVPHPAWVVSHDRV 176

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
            L  +LGEGAFG V+KG L       H  + VA KT   ++  K +    ++EA++MR+ 
Sbjct: 177 RLKDELGEGAFGRVYKGILQ----VGHTYMTVAAKTCVGQASDKTKRASFLQEAKVMRDY 232

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYI 239
            H N+V+F G+A   EPL +I+E   GG+L   L K   H  +  +Y    +A+ GL Y+
Sbjct: 233 KHENLVQFIGIACQKEPLMIIVEFCGGGSLLKYLRKKGAHLGIATRYRFGKEASAGLKYL 292

Query: 240 HEKNLMHRDVAARNCLYGG 258
            EK  +HRDVAARNCL   
Sbjct: 293 EEKRCIHRDVAARNCLLTE 311


>UniRef50_A8XFQ1 Putative uncharacterized protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8XFQ1_CAEBR
          Length = 643

 Score =  235 bits (599), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 92/297 (30%), Positives = 144/297 (48%), Gaps = 44/297 (14%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEP------------------------ 38
           ++ +     +HG + RED+  +L   G +L+R S                          
Sbjct: 215 EEHICKMPNFHGYICREDVTILLKNSGDWLVRLSVQPCKENEKKASKGAKSVERGSKARG 274

Query: 39  ----VKGEKRQFVLSV-----VGEKKTSANHFVVRESDHKVYVDKIG-FPTIIELVNHYV 88
                K   + FV+SV     V   K+S  + V++ +D K  +D I  F  + +  ++Y 
Sbjct: 275 SKNRSKDNNKVFVISVHSRKAVSPGKSSCRNLVIKTNDGKFSIDSIKWFMKVADFFSYYQ 334

Query: 89  STKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT-KKLGEGAFGEVWKGKLL-KILDA 146
            T  ++   +      L        WE + +D+EL  KKLGEGAFG+V  G++  K    
Sbjct: 335 GTVATYKESEFQ----LLHPCHLSVWEFHQDDIELMSKKLGEGAFGDVRVGRMTTKDPKK 390

Query: 147 NHQPVLVAVKTAK--LESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIME 204
               V VAVK  K  LES+T++Q+ E++ EAR+MR LDH NV++ +GV+   EPLY++ E
Sbjct: 391 TVAVVDVAVKMLKNSLESITRDQVDELLHEARVMRRLDHPNVLRTYGVSVLREPLYLMNE 450

Query: 205 LADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
           L   GAL   L + H    +  K   +  AA G+AY+H + ++HRD+A RN      
Sbjct: 451 LCANGALREYLKENHKTITISDKLNFVLGAARGVAYLHSQRIIHRDLAVRNVFLTEN 507


>UniRef50_UPI00004D86FC Tyrosine-protein kinase Tec (EC 2.7.10.2). n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=UPI00004D86FC
          Length = 647

 Score =  234 bits (598), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 66/253 (26%), Positives = 112/253 (44%), Gaps = 23/253 (9%)

Query: 23  EMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDH--KVYV-DKIGF 77
           +ML   K G F++R S               GE  T   H+ ++E+ +  K Y+ +K  F
Sbjct: 303 QMLQIDKEGGFIVRNSSQAGLYTVSLYTKYGGEGSTCIRHYHIKETQYPKKYYLAEKHVF 362

Query: 78  PTIIELVNHYVSTKESFSTK------DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGA 131
            TI E++ ++        T+           A         KWE+   ++   K+LG G 
Sbjct: 363 NTIPEMIEYHKHNAAGLVTRLRYPVCSKNKSAPTTAGFSYDKWEINPSELTFMKELGSGL 422

Query: 132 FGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFG 191
           FG V  GK             VA+K  +  +M++E   + + EA++M  L H+ +V+ +G
Sbjct: 423 FGVVRLGKWRAQYK-------VAIKAIREGAMSEE---DFIEEAKVMMKLTHLKLVQLYG 472

Query: 192 VAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
           V     P+Y++ E  + G L + L + H  F       +       ++Y+ + N +HRD+
Sbjct: 473 VCTQQRPIYIVTEFMEHGCLLNYLRQRHGQFSPDILLSMCQDVCEAMSYLEQNNFIHRDL 532

Query: 250 AARNCLYGGGQVL 262
           AARNCL     V+
Sbjct: 533 AARNCLVNDAGVV 545


>UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase n=36
           Tax=Euteleostomi RepID=MATK_HUMAN
          Length = 507

 Score =  232 bits (593), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 71/271 (26%), Positives = 118/271 (43%), Gaps = 29/271 (10%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
            D  L    ++HG +  ++  + L   + G FL+R S    G+   +VL V   +     
Sbjct: 113 ADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGD---YVLCVSFGRD--VI 167

Query: 60  HFVVRESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVK-----AVLKQAVERQK 113
           H+ V   D  + +D+ + F  ++++V HY   K +  TK    K        ++ + R  
Sbjct: 168 HYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAG 227

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           W L  + + L  ++GEG FG V +G+ L           VAVK  K +       +  + 
Sbjct: 228 WLLNLQHLTLGAQIGEGEFGAVLQGEYLGQ--------KVAVKNIKCDVTA----QAFLD 275

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIY 230
           E  +M  + H N+V+  GV      LY++ME    G L + L    +      +  +   
Sbjct: 276 ETAVMTKMQHENLVRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSL 334

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
             A G+ Y+  K L+HRD+AARN L     V
Sbjct: 335 HVAEGMEYLESKKLVHRDLAARNILVSEDLV 365


>UniRef50_Q21764 Protein R05H5.4, partially confirmed by transcript evidence n=6
           Tax=Caenorhabditis RepID=Q21764_CAEEL
          Length = 414

 Score =  232 bits (592), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 78/254 (30%), Positives = 134/254 (52%), Gaps = 14/254 (5%)

Query: 10  KYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHK 69
            Y+HG L   D  ++L   G F++   + +   K Q  L+V    K     + ++ +   
Sbjct: 15  PYFHGALMNIDADQLLVNEGDFMVTMKKQLDINKLQLFLAV--RLKKGIRRYEIKRTSKT 72

Query: 70  VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
             +       I++L+N  +   +    +    K VLK+A+ + K++L H+DV   KK+G 
Sbjct: 73  AKIGGKTSQNIVKLIN--MLKADPIEIRGE--KVVLKRAIPKGKFQLMHKDVIFQKKIGA 128

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           GA+G V++GKL+K  +      ++AVK    E   ++ + E+M+EAR+M+  DH N+VKF
Sbjct: 129 GAYGTVYRGKLVKTDE------VIAVKKLDPEGADEDGLAEMMKEARVMQLYDHPNIVKF 182

Query: 190 FGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHR 247
            G      P  +++E  +GGA++  L        +  + +  Y AA G+ Y+H+KN +HR
Sbjct: 183 HGFILDDLPYLLVLEYCNGGAVEDRLRDKGEKIKVPTRVKYTYMAACGMDYLHKKNCIHR 242

Query: 248 DVAARNCLYGGGQV 261
           D+A+RNCL   G V
Sbjct: 243 DIASRNCLIHKGVV 256


>UniRef50_A8WPD7 Putative uncharacterized protein n=4 Tax=Caenorhabditis
           RepID=A8WPD7_CAEBR
          Length = 423

 Score =  230 bits (587), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 76/257 (29%), Positives = 130/257 (50%), Gaps = 18/257 (7%)

Query: 7   LHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
           L+  Y+HG L  +D  ++L   G F++     +   K    L      K     + ++  
Sbjct: 11  LNLPYFHGALMNQDADQLLVNDGDFMVTMKLQIDINKLVVRL------KKGIRRYEIKRL 64

Query: 67  DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKK 126
                +      TI +L+N   +       +    K VLK+A+ + K++L H+DV   KK
Sbjct: 65  PGSAKLGSRSKETIDKLINSLKTDVLEIKGE----KIVLKRAIAKGKFQLMHKDVIFKKK 120

Query: 127 LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINV 186
           +G GA+G V++G+L+K  +      ++AVK    ES  ++ + E+M+EAR+M+  DH N+
Sbjct: 121 IGAGAYGTVYRGRLVKTNE------VIAVKKLDPESADEDGLAEMMKEARVMQLYDHPNI 174

Query: 187 VKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNL 244
           VKF G      P  +++E  +GG+++  L        +  +    Y AA G+ Y+H+K  
Sbjct: 175 VKFHGFILDDLPYLLVLEFCNGGSVEDRLRDKGSRLTVPTRVHYTYMAACGMDYLHKKGC 234

Query: 245 MHRDVAARNCLYGGGQV 261
           +HRD+A+RNCL   G V
Sbjct: 235 IHRDIASRNCLIHRGIV 251


>UniRef50_Q9XXE5 Protein Y43C5B.2, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q9XXE5_CAEEL
          Length = 245

 Score =  228 bits (582), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 85/225 (37%), Positives = 128/225 (56%), Gaps = 16/225 (7%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVG---EKKTS 57
           M    +  + YYHG LPRED++ +L   G F++R SEP  G  R  +LSV+      +  
Sbjct: 8   MQRPSIEKEPYYHGFLPREDVKTVLKNNGDFVIRISEPQAGSPRSNILSVMHCVPPMEEE 67

Query: 58  ANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
             H+V++    K++++K+ F +I E+V  +++ KES           L +A+ RQ WEL 
Sbjct: 68  IKHYVIKTKGDKIFIEKVSFLSIPEMVEWHLTKKESVQKD-----VFLIKAISRQAWELD 122

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
           H+++E  KKLGEGAFGEV  G +        + V VA+K AKL ++TKEQIKE M EAR+
Sbjct: 123 HDNIEPLKKLGEGAFGEVMMGTMK--FRKGGKSVQVAIKQAKLSNLTKEQIKEFMGEARV 180

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPM 222
           MR+L H +VV+F+GV      + +        +L+  L K H  +
Sbjct: 181 MRSLSHPHVVRFYGVPRRRVNVAL------CRSLNEFLAKCHRKL 219


>UniRef50_A8QEG4 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QEG4_BRUMA
          Length = 392

 Score =  227 bits (580), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 85/253 (33%), Positives = 123/253 (48%), Gaps = 12/253 (4%)

Query: 8   HQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESD 67
               +HG++P ED   +L   G FL+R  E  +G K    LS+        N  +V    
Sbjct: 25  DMDCWHGMIPDEDTAMLLKNSGDFLMRAVEHDRGYK--ITLSIRW-GNEVVNSEIVPGIQ 81

Query: 68  HKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKL 127
                    F    +L++ Y  TK   +     V   L+  + RQ WEL H+ + L KK+
Sbjct: 82  GGYKFQGKHFCQTKDLIDSYQVTKRPLTVNSIVV--TLEIPIRRQHWELQHKMIRLGKKI 139

Query: 128 GEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVV 187
           G G+FG V+KG    I     + + VAVK      +T E    + REAR+MR  DH NVV
Sbjct: 140 GSGSFGTVYKG---AITIGIKKSITVAVKELTE--ITAEASNALWREARVMRMYDHPNVV 194

Query: 188 KFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAYIHEKNLM 245
           K++GVA    P Y++ME   GGA+D  L           + +++ +AA GL Y+H +  +
Sbjct: 195 KYYGVANDYTPYYLVMEFVSGGAVDEYLCKKGKKIAAKARVKILQEAAIGLEYLHRQKCL 254

Query: 246 HRDVAARNCLYGG 258
           HRD+A RN L G 
Sbjct: 255 HRDIACRNLLIGD 267


>UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E52F9
          Length = 588

 Score =  227 bits (579), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 68/273 (24%), Positives = 117/273 (42%), Gaps = 38/273 (13%)

Query: 11  YYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVV-------GEKKTSANH 60
           +Y   + R   QE+L    K G F++R S         + +SV        GEK     H
Sbjct: 213 WYSKNMNRMQAQELLMREGKEGAFMVRDSS----HMGVYTVSVFTKAPSQSGEKNPKVKH 268

Query: 61  FVVRESDHK----VYVDKIGFPTIIELVNHYVSTKESFSTK-------DGTVKAVLKQAV 109
           + +R+++         +   F TI EL++++        T+       DG+    +    
Sbjct: 269 YQIRQTETGAGPFYLAENYLFNTIPELIHYHQHNAAGLITRLRHPVSPDGSSAQQVSAPF 328

Query: 110 ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
           E  +WEL  +++ L +++G G FG V +G   K   A            +   M+++ ++
Sbjct: 329 EADQWELNPDELTLGQEIGSGQFGLVLEGWWKKKKVAVK--------MIRDGCMSEDDLQ 380

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYE 227
           E   EAR+M  L H  +V+ + V++   PL ++ E  + G L   L   K          
Sbjct: 381 E---EARVMMKLSHHKLVQLYAVSSQRSPLCLVFEFMENGCLSDYLRARKGSLSQETLLN 437

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
           +    + G+AY+   N +HRD+AARNCL     
Sbjct: 438 MCMDVSEGMAYLESSNFLHRDLAARNCLVSENN 470


>UniRef50_A8WSQ7 Putative uncharacterized protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8WSQ7_CAEBR
          Length = 481

 Score =  226 bits (578), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 84/308 (27%), Positives = 137/308 (44%), Gaps = 56/308 (18%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQF-------------- 46
           M + +LL   ++HG + +E    +L   G +++R S   + + +                
Sbjct: 26  MIENNLLRYPFFHGFVLQELQLMLLKTNGDYIMRLSHQPEKKAKSIGAKKASAEKTGPVD 85

Query: 47  ---------VLSV------------------VGEKKTSANHFVVRESDHK---VYVDKI- 75
                    VLSV                  V +K+    H  + E + K    +V++  
Sbjct: 86  QSTLTRVILVLSVNITQKPDNTRSFYGDLDEVKQKENMDMHVCIEEINGKWVSFFVERRT 145

Query: 76  GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTK--KLGEGAFG 133
            F +I +L+ +Y +    +       +  LK+ +  Q WEL  + +E+ K  KLGEGA+G
Sbjct: 146 KFASIDDLITYYRTNPICY----QATRVFLKRPIPLQDWELRKDGLEVIKTKKLGEGAYG 201

Query: 134 EVWKGKLLKILDAN----HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           EV+ GK  +    +    H+   VAVK  K +  ++  + EIM EARL   L H NV+ F
Sbjct: 202 EVYLGKWAQPFSVDQKEFHKWCDVAVKMLKKDD-SRAALFEIMHEARLQLQLRHKNVLAF 260

Query: 190 FGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
            GV    +P+ ++ E  + G+L   L K    +  K      ++ GL YIH K L+HRD+
Sbjct: 261 RGVFLLKKPIMLVSEFCENGSLKDYLQKNKVGVDDKLRFCLGSSCGLEYIHFKGLIHRDL 320

Query: 250 AARNCLYG 257
           A RN L  
Sbjct: 321 ATRNILVS 328


>UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C5J9R9_SCHMA
          Length = 565

 Score =  226 bits (576), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 64/269 (23%), Positives = 110/269 (40%), Gaps = 34/269 (12%)

Query: 11  YYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS----ANHFV 62
           +Y   + R +    L    N  G +L+R S     E + + LSV             H+ 
Sbjct: 181 WY--NIGRREADRKLLLVGNPQGTYLIRPSS----ETQNYALSVRHYDSEKNMWVVKHYR 234

Query: 63  VR--ESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTK-DGTVKAVLKQAVERQKWELYH 118
           +R  +++   ++  +  FP I +LVN+Y    +    +         +  V    + +  
Sbjct: 235 IRILDNNGGFFISIRTTFPNIQDLVNYYTVHPDGLCCRLSIPCPRAYRPPVHFVMFAIIR 294

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           + +   +KLG+G FGEV+  K        +  V VAVK      +        + EARLM
Sbjct: 295 DSITRIRKLGQGTFGEVYLAKW-------NGSVEVAVKM----RLDPTDRSRFIEEARLM 343

Query: 179 RNLDHINVVKFFGVAAG--TEPLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAA 233
               H  +V+  GV      +P+Y+I EL    AL   L         +    +++ Q A
Sbjct: 344 HAFHHPRIVQLLGVCTEPEDQPVYIITELMRKXALYDFLRTEEGHKLTLDDLIDIMAQIA 403

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +G++Y+   N +HRD+ A N L      +
Sbjct: 404 SGMSYLEXMNSVHRDLRAANILVDQDYSV 432


>UniRef50_UPI0000ECD739 Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow
           tyrosine kinase gene in chromosome X protein)
           (Epithelial and endothelial tyrosine kinase) (ETK)
           (NTK38). n=2 Tax=Gallus gallus RepID=UPI0000ECD739
          Length = 633

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 67/269 (24%), Positives = 123/269 (45%), Gaps = 24/269 (8%)

Query: 8   HQKYYHGLLPREDIQEMLNKP---GQFLLRTSEPVKGEKRQFVLSVVGE-KKTSANHFVV 63
            + +Y   + R   +++L++      F +  ++  +    +      GE KK +  H+ V
Sbjct: 247 QEIWYVAGISRAQSEQLLHQSPKISGFTVALAQMSRLYTSKMKSPFYGENKKGTVKHYHV 306

Query: 64  -RESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK------WE 115
            +  ++K Y+ +   F TI +L+N++         +   V +     V          WE
Sbjct: 307 HKTPENKYYLTENHCFETIPKLINYHQHNSAGMVPRLRHVVSTQINKVPATASLGNGIWE 366

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           L  E++   ++LG G FG V  GK   + D       VAVK  K   ++++   E + EA
Sbjct: 367 LKREEIVPLRELGSGQFGAVHLGKWKGLYD-------VAVKMIKEGVVSED---EFVEEA 416

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAA 233
           + M  L+H  +V+ +GV +   P+Y++ME    G+L S L         ++  E+ Y   
Sbjct: 417 QTMMKLNHPKLVRLYGVCSKLYPIYLVMEYMPNGSLLSYLQIHGKELQPLQLLEICYDVC 476

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + +A++    L+HRD+AARNCL      +
Sbjct: 477 DAMAFLESCQLIHRDLAARNCLVDSNLTV 505


>UniRef50_Q9XW34 Protein Y69E1A.3, partially confirmed by transcript evidence n=4
           Tax=Caenorhabditis elegans RepID=Q9XW34_CAEEL
          Length = 563

 Score =  223 bits (570), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 72/252 (28%), Positives = 120/252 (47%), Gaps = 13/252 (5%)

Query: 12  YHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVY 71
           YHG+L   + +++L     +L+R +     +     L +    K    H+ +  ++    
Sbjct: 95  YHGVLFGSEAEKLLTWDRAYLVRRAITKPNK----FLCISVNWKNKIFHYQLDFNEDGWC 150

Query: 72  VDKI--GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
             K+   FPT+      ++  ++           ++     R    L H  + L KKLG 
Sbjct: 151 CKKLYEKFPTMPN--RRFLHIRQLLEAWSQATPFLI--PTPRGSNVLIHSTINLDKKLGC 206

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           GAFGEV+KG+   +   N  P+ VAVK   L +  ++QI+E   EA++M  L H N+V F
Sbjct: 207 GAFGEVFKGQYKAVGSTN-PPIEVAVKRI-LGNAKRKQIQEFCNEAQIMTVLQHENIVAF 264

Query: 190 FGVAAGTEPLYVIMELADGGALDSALG-KLHFPMIKKYELIYQAANGLAYIHEKNLMHRD 248
           +G A+  EP+ V+MEL  GG L        + P ++        A+G+ ++  K ++HRD
Sbjct: 265 YGFASLEEPIMVVMELVTGGDLRKYFQTTQNIPKLQILWFAMNVASGMRHLSSKGIIHRD 324

Query: 249 VAARNCLYGGGQ 260
           +AARNCL     
Sbjct: 325 LAARNCLVTQDL 336


>UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine kinase n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793830
          Length = 686

 Score =  222 bits (566), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 64/273 (23%), Positives = 121/273 (44%), Gaps = 36/273 (13%)

Query: 10  KYYHGLLPREDIQEMLNK---PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
           ++YHG L R +   +L      G FL+R        +  +VLS++   +    HF +++ 
Sbjct: 289 QWYHGKLDRHEATAILKTKDVDGCFLVRM-----NRQSGYVLSMMCTNQ--CYHFQIQDR 341

Query: 67  DHKVYVDKIGF-PTIIELVNHYVSTKESFSTK-------------DGTVKAVLKQAVERQ 112
           D   ++D   +  ++  L+ HY    +    K                    LK+   + 
Sbjct: 342 DKYYFIDNGPYLNSLEHLIQHYTLFPDGLPNKLEVPVSPAVIPPLPKGFPFTLKKPKPKH 401

Query: 113 KWE----LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
           + E    +  +++ L + +GEG FG V+KG      + +     VA+K  + + M+    
Sbjct: 402 QTEFQDNIMRDNLILDEVIGEGEFGSVYKGTF---QNRDGFEEKVAIKMLRYD-MSSTNK 457

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHF---PMIKK 225
            E +REA +M +L+H  +++  G+     PL ++ EL   G++ + +        P  + 
Sbjct: 458 SEFLREAHVMMSLNHECIIRLIGIC-EGPPLLMVQELIALGSMLTHIITHPELISPNYEL 516

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
                Q A+G+ Y+ +K  +HRD+AARN L   
Sbjct: 517 KMWAAQIASGMCYLEQKRFVHRDLAARNILLAD 549



 Score = 72.1 bits (176), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 22/119 (18%), Positives = 44/119 (36%), Gaps = 14/119 (11%)

Query: 11  YYHGLLPREDIQEML-----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           +YHG + R+  + +L      + G FL+R S    G+   +VL V+        H+ +R 
Sbjct: 12  WYHGKISRDTAEIILLDHESKEDGLFLVRESNSASGD---YVLCVLQN--NEVVHYQIRR 66

Query: 66  SDHKVYV---DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDV 121
                +    ++     +  L+ HY    +  S      K ++K             ++
Sbjct: 67  HGEDAFFSIDEQNIMHGLETLIEHYCKVNDP-SLGVQLSKPIVKDPPPHDTRRHGRTNL 124


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score =  221 bits (565), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 76/275 (27%), Positives = 124/275 (45%), Gaps = 30/275 (10%)

Query: 8   HQKYYHGLLPREDIQEMLN----KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
            Q ++HG + RE+ ++ +     + G FL+R     + E   F L V    K    H+++
Sbjct: 160 KQLWFHGAISREESEQRMKAFGLRDGLFLVRE----RTEVNSFALCVAV--KNDIYHYLL 213

Query: 64  RESD-HKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLK-------------QA 108
             +   ++ ++    F  ++++V+HY  T +        V AV +             + 
Sbjct: 214 EMNTLGQLSIENGRKFENLLQVVDHYSRTPDGLLCTLVDVCAVTRFEAQAVPMPGAVVKR 273

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
           V+     +   ++    +LG G FG V  G            V  A+K  K       Q 
Sbjct: 274 VKHGPRRIEDSELSTQGELGAGTFGTVRLGVYR--PKNGEPEVQCALKYLKQSEELPNQK 331

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYE 227
            EI+REA  M  LDH N+V+ FG+    +P+ ++MELA  G L+  L K   FP+IK   
Sbjct: 332 AEILREADAMAALDHCNIVRLFGICV-GDPICLVMELARQGPLNKFLRKRPTFPVIKILN 390

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCL-YGGGQV 261
           +  Q + G+AY+ E   +HRD+AARN L      V
Sbjct: 391 MALQVSRGMAYLEEVRFVHRDLAARNVLVVDDDNV 425



 Score = 90.2 bits (223), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 32/125 (25%), Positives = 58/125 (46%), Gaps = 11/125 (8%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNK----PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           DL  + +YHG + R D +++L+      G FL+R S    GE   +VLS+  + K    H
Sbjct: 3   DLSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGE---YVLSLSFQGKK--YH 57

Query: 61  FVV-RESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
           +++ R  D  V + D   F + IEL+ ++    +   T        L     +    + H
Sbjct: 58  YIISRHPDGSVAIQDGAKFDSPIELIQYHTKKVDGLITTLKQPCCRLPGQPPQGYRFISH 117

Query: 119 EDVEL 123
           E++++
Sbjct: 118 EEMQM 122


>UniRef50_O44570 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=O44570_CAEEL
          Length = 448

 Score =  221 bits (564), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 90/283 (31%), Positives = 142/283 (50%), Gaps = 43/283 (15%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEK---RQFVLSVVGEKKTS 57
           + +K L    +YHG  PRED+Q  L+  G FLLR SE V+GE    R+ +LS++     S
Sbjct: 170 ILEKKLREFNFYHGFFPREDLQTTLHNLGDFLLRVSEVVEGEHKVNREVILSLIPVSTVS 229

Query: 58  -----------------------------ANHFVVRESDHKVYVD-KIGFPTIIELVNHY 87
                                          + V++   +  + +    F +I +L+N+Y
Sbjct: 230 RDEEEKKKVRRLIQANAPACCLYFLTYLAPRNVVIKRVRNLFFCEPPRTFESISDLLNYY 289

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
                      GT +  LK  + +Q WE  H DV + K LGEGAFG+V  G L      +
Sbjct: 290 TKNHGG--CASGTFQ--LKHPILQQSWEFMHSDVTIGKVLGEGAFGKVCSGTLKL---KD 342

Query: 148 HQPVLVAVKTAKLES-MTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELA 206
              V VA+K  K+ + ++K +IKE+M EAR +RN +H NVV+ +GVA   +PLY+++EL 
Sbjct: 343 GTNVDVAIKMTKVSAFLSKMKIKEMMNEARFIRNFNHKNVVRLYGVAHHEQPLYILLELV 402

Query: 207 DGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHR 247
            GG+L   + K      ++++ +    A  G+ Y+H+ N +HR
Sbjct: 403 KGGSLQDHMKKEKGAVSIVERIKFCRGAGRGIEYLHQNNCIHR 445


>UniRef50_Q9U3B5 Protein K09B11.5a, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q9U3B5_CAEEL
          Length = 589

 Score =  221 bits (563), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 76/256 (29%), Positives = 125/256 (48%), Gaps = 15/256 (5%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           L    +YHG++  + ++++L     +L+R +   +  K+   LSV  + K    HF +  
Sbjct: 71  LKFYPWYHGMMFGQTVEKLLKWDYAYLVRRA-MQRNSKKVLCLSVKIDGKIC--HFTLNS 127

Query: 66  SDHKVYVDKI--GFPTI-IELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           +       K+   FP I  +   H     +++S    ++       V R++  L H  + 
Sbjct: 128 NKDGWSCGKLLAKFPKITPKRFQHIHHLLDAWSLVVNSIV-----PVPRRQLVLQHNCIH 182

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L   LG GAFGEV K + +     N   V VAVK   + +  +EQ++E   EA++M  L 
Sbjct: 183 LENILGNGAFGEVLKARYIPRGHTNG--VEVAVKRV-IGTAQREQMQEFCHEAQIMGTLK 239

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIHE 241
           H NVVK +G+A+  +P+ ++MEL  GG L   L      P  +        ANG+ ++  
Sbjct: 240 HDNVVKLYGIASLEQPIMLVMELITGGDLKKYLQSTPSIPNRQLIAFALDIANGMRHLVI 299

Query: 242 KNLMHRDVAARNCLYG 257
           K ++HRD+AARNCL  
Sbjct: 300 KKVIHRDLAARNCLIS 315


>UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine kinase n=3 Tax=Hydra
           magnipapillata RepID=UPI0001925EBD
          Length = 730

 Score =  220 bits (561), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 77/266 (28%), Positives = 129/266 (48%), Gaps = 29/266 (10%)

Query: 6   LLHQKYYHGLLPREDIQ-EMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           L    +Y G++ R      +L+    G FL+R S    G+   + LS+    +TS  H+ 
Sbjct: 95  LKKYDWYTGVMGRSSANLALLSNGSAGSFLVRKSTSKPGD---YTLSL--HNETSLKHYH 149

Query: 63  VRESDHK-VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-WELYHED 120
           ++++ +   Y+ K  F  +  LV HY           G +   LK A  ++K W++ H  
Sbjct: 150 IKKTKNCTFYILKEEFSNLPSLVEHYKKV-------SGGLPRTLKDACSQKKLWDIPHNK 202

Query: 121 VELTKK-LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           + LTKK LG+G FG V +G+L          V VAVK  K ++   ++ K  ++EA  M+
Sbjct: 203 ITLTKKHLGKGNFGIVLEGRLF-------SSVNVAVKVLKTDNCKMKETK-FLKEANNMK 254

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAANGL 236
            L H N++  +GV      +Y+++ELA  GAL   L      +  +     +  Q ++G+
Sbjct: 255 ELSHKNLIHCYGVCYFDSYVYIVLELALHGALHKFLQTSTGQNLTLHDLVHIATQISSGM 314

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQVL 262
            ++    L+HRD+AARN L     V+
Sbjct: 315 THLSHIRLLHRDIAARNMLVASKMVI 340


>UniRef50_Q23102 Protein W01B6.5, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q23102_CAEEL
          Length = 536

 Score =  220 bits (561), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 86/314 (27%), Positives = 138/314 (43%), Gaps = 62/314 (19%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGE-------------------- 42
           +  +     +HG + RED+  +L   G FL+RTS                          
Sbjct: 101 EDFITKMPCFHGFIGREDLMSVLKNVGDFLIRTSVQPNKHEVEKMKKNQADVKVLGNLSR 160

Query: 43  ---------------------KRQFVLSVVGEKKTS----------ANHFVVRESDHKVY 71
                                +R+FV+SV  + K              + V++  +  V+
Sbjct: 161 EKCAKKEKEKEEKLAGMGDVGRREFVISVYCKDKEKPATDKPQYTPIRNLVIKRDNGMVH 220

Query: 72  VDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT-KKLGE 129
           V+    F T+ E   +Y         +       L   +    WE  HED+ L  KKLGE
Sbjct: 221 VEPLRKFKTLTEFFGYYQKNS-GICKE---TDFQLITPIPLSNWEFIHEDIALQQKKLGE 276

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKL-ESMTKEQIKEIMREARLMRNLDHINVVK 188
           GAFGEV  GK+   L +  + V VAVK  +  E + +EQ+ E++ EAR+MR +DH NV++
Sbjct: 277 GAFGEVRIGKMK--LKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMMDHKNVLR 334

Query: 189 FFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI--KKYELIYQAANGLAYIHEKNLMH 246
            +G+A   EPLY++ E+   GAL   L +    +   +K   +  ++ G+ Y+H +  +H
Sbjct: 335 SYGIAVLKEPLYLMTEMCACGALREYLRENQETVTLAEKLFFVVGSSRGVQYLHSQKTIH 394

Query: 247 RDVAARNCLYGGGQ 260
           RD+A RN L    +
Sbjct: 395 RDLAVRNILLSEDR 408


>UniRef50_Q21299 Protein W08D2.8, partially confirmed by transcript evidence n=2
           Tax=Caenorhabditis RepID=Q21299_CAEEL
          Length = 543

 Score =  220 bits (561), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 68/254 (26%), Positives = 118/254 (46%), Gaps = 14/254 (5%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           LL + +YHG++  +  +++L     +++R S    G   +F L +    +    HF    
Sbjct: 67  LLQRNWYHGMMFGKAAEKLLKWESSYIVRRS---MGPTHKF-LCITARVEDKYFHFQFNW 122

Query: 66  SDHKVYVDKI--GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
           +        +   FP I   V  Y    +        V  ++   + R    L H  + L
Sbjct: 123 NSEGWSCPILYEKFPRIP--VKRYEHIYQLLDAWSLVVNQLV--PISRCSMILQHSSIAL 178

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
             +LG GAFGEV K K + +      P  VAVK   +    + Q+ +   EA +M  L+H
Sbjct: 179 ENQLGRGAFGEVIKAKYVPM--GATVPTEVAVKRL-IGDAKRPQLVDFCNEANIMTLLEH 235

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIHEK 242
            N+V  +G A+  +P+ +++E   GG L   L +  + P  +  +   + A+G+ ++  K
Sbjct: 236 KNIVALYGFASLQQPIMLVIEFVPGGDLRKYLQRTPNVPSKQIIKFAMEIASGMKHLSSK 295

Query: 243 NLMHRDVAARNCLY 256
           N++HRD+AARNCL 
Sbjct: 296 NVIHRDLAARNCLI 309


>UniRef50_Q19704 Protein F22B3.8, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q19704_CAEEL
          Length = 442

 Score =  219 bits (559), Expect = 7e-56,   Method: Composition-based stats.
 Identities = 91/304 (29%), Positives = 138/304 (45%), Gaps = 54/304 (17%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTS------------------EPVKGE 42
           M D  LL  +++HG + +E    +L   G FLLR S                  +P+   
Sbjct: 1   MIDNYLLRYQFFHGFVLQELQLILLKTNGDFLLRLSHQPEKNAKKPTTPDKSATDPIPLT 60

Query: 43  KRQFVLSVVGEKKTSAN-----------------HFVVRESDHK---VYVDKI-GFPTII 81
           +   VLSV   +KT                    H  + E+  K    Y+++   FPTI 
Sbjct: 61  RVILVLSVNITQKTGTTRSFYGDLEDVKKENMDMHLFIEETAGKWTSFYIERRFKFPTID 120

Query: 82  ELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT-KKLGEGAFGEVWKGKL 140
           EL+N+Y      +       +  LK+ +  Q WEL  E +++T KKLGEGAFG V+ G+ 
Sbjct: 121 ELINYYKVNPICYH----NTRVFLKRPIVLQDWELRAEGIDMTPKKLGEGAFGIVYLGRW 176

Query: 141 LKILDAN----HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGT 196
            +    +    H+   VAVKT K +  ++  + E+M EARL   L H NV+ F GV    
Sbjct: 177 AQPFSVDQKEFHKWCDVAVKTVKNDD-SRAALLEVMHEARLQLQLRHKNVLAFRGVFLLK 235

Query: 197 EPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLY 256
           +P+ ++ E  +       L K    + +K      ++ GL YIH K L+HRD+A RN L 
Sbjct: 236 KPIMLVSEFCEN-----YLQKSKVSVDEKLRFCLGSSCGLEYIHFKGLIHRDLATRNILV 290

Query: 257 GGGQ 260
              +
Sbjct: 291 SADK 294


>UniRef50_A8P3F9 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P3F9_BRUMA
          Length = 441

 Score =  218 bits (557), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 78/263 (29%), Positives = 140/263 (53%), Gaps = 15/263 (5%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           M++++     ++HG L  +D+ ++L   G FLL+T      +K + +L++    +T    
Sbjct: 1   MSEEN--SLPFFHGALLDDDVDKLLELNGDFLLQTKFEQSKKKNKLILAIRHGHRTI--R 56

Query: 61  FVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
             +   +    +    F T+  L+ +Y   +E      G    +L++ +++ ++EL H D
Sbjct: 57  IPISRLEKGYRIFGRSFSTMNTLIKYY---QEHNIEAHGIDSLLLRRPIKKGRFELNHSD 113

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           +++ KK+G GA+G V+KG LLK L        VA+K       +++ + ++M+EAR+M+ 
Sbjct: 114 IKIMKKIGYGAYGTVYKGILLKNL------CPVAIKRIDCADKSEQALIDLMKEARVMQL 167

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELIYQAANGLAY 238
            DHINVVKF+G     EP  ++ME    G+++  L +      +  + ++  Q A GL Y
Sbjct: 168 YDHINVVKFYGFIVDREPFLLVMEYCKDGSVEDKLRQYGRRLSIESRIDIACQIARGLEY 227

Query: 239 IHEKNLMHRDVAARNCLYGGGQV 261
           +H K  +HRD+A RNCL  G  V
Sbjct: 228 LHLKGCIHRDIATRNCLLNGAVV 250


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score =  218 bits (555), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 63/241 (26%), Positives = 106/241 (43%), Gaps = 27/241 (11%)

Query: 5   DLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVG--EKKTSA 58
            +  + ++   + R +    L    N  G FL+R SE   G    + LS+          
Sbjct: 110 TMETEAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPG---SYSLSMRDFDNNGDGV 166

Query: 59  NHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTK--DGTVKAVLKQAVERQKW 114
            H+ +R  D+  +    KI F ++ ELV HY    +   TK          ++   + +W
Sbjct: 167 KHYRIRNMDNGGFYITTKISFNSLKELVQHYSRDSDGLCTKLVKPCQSKAPQKPWWQDEW 226

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+  E ++L +KLG G FGEVW G         +    VA+K  K+ +M+   ++  + E
Sbjct: 227 EIPRESLKLERKLGAGQFGEVWMGVY-------NNERRVAIKCLKIGTMS---VEAFLAE 276

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIYQ 231
           A +M+NL H  +V+ F V    EP+Y++ E  + G+L   L         M    ++  Q
Sbjct: 277 ANMMKNLQHARLVRLFAVVTQ-EPIYIVTEYMENGSLVDYLKTTEGSSLSMNTLIDMASQ 335

Query: 232 A 232
           A
Sbjct: 336 A 336


>UniRef50_B3XVX8 Protein tyrosine kinase fes/fps n=1 Tax=Codonosiga gracilis
           RepID=B3XVX8_9EUKA
          Length = 792

 Score =  217 bits (554), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 78/261 (29%), Positives = 128/261 (49%), Gaps = 19/261 (7%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVR 64
            +   + Y G +PR ++  +L+ PG FL+R     +    ++VLSV+ E      HF + 
Sbjct: 428 SVEDLECYFGPIPRNEVPMILSDPGDFLIRLGS--ENSATKYVLSVLEEGGN-CRHFNIF 484

Query: 65  ESDHKV-YVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL-YHEDVE 122
              +    ++K  FP+I  L+ HY+    S S   G     +   V R+K E+   +D+E
Sbjct: 485 YCPNGYVKIEKQEFPSISHLIRHYIDNDLSLSKNSG---VTIAHGVSRKKMEIWKPKDLE 541

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
              KLG+G FG V K K     D      + AVKT   ES+      E ++EA       
Sbjct: 542 SAAKLGKGCFGVVQKMKSKISDD------VFAVKTCSDESVHP---WEFLKEALDFAKFK 592

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK-KYELIYQAANGLAYIHE 241
           H+N+    G++  + P +++M+L   GA++S L       ++ K++   +A  G+ Y+  
Sbjct: 593 HVNICVHRGISL-SFPYFILMDLCGNGAVNSYLHDHKDTSLEIKFKWALEACEGMEYLTT 651

Query: 242 KNLMHRDVAARNCLYGGGQVL 262
            N++HRD+AARNCL     VL
Sbjct: 652 NNVVHRDLAARNCLLTDDLVL 672


>UniRef50_C4Q0E9 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4Q0E9_SCHMA
          Length = 1057

 Score =  217 bits (554), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 54/204 (26%), Positives = 88/204 (43%), Gaps = 19/204 (9%)

Query: 69  KVYVDKIGFPTIIELVNHYVSTKESFST-------KDGTVKAVLKQAVERQKWELYHEDV 121
              ++   F ++ +LV+H+    +  +        K     + L+        E+   ++
Sbjct: 2   YYVIESNKFTSVSDLVHHHEKHSDGLACTLLYPAPKRDRTSSELRMDPSFDIREIDRTEI 61

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
            +  KLG G +G V++             VLVAVKT K     ++   E + EARLM++L
Sbjct: 62  VMKHKLGSGQYGVVYEAVWKPYN------VLVAVKTLKENVTVRD---EFLEEARLMKSL 112

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIYQAANGLAY 238
            H N+V   G      P Y++ E    G L   L    +          +  Q A G+AY
Sbjct: 113 RHPNLVTLLGACTREPPYYIVTEFMCNGNLLDYLRTHPRTELTPSVLLHMATQVARGMAY 172

Query: 239 IHEKNLMHRDVAARNCLYGGGQVL 262
           + + N +HRD+AARNCL G    +
Sbjct: 173 LEQHNFIHRDLAARNCLVGTQHTI 196


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score =  213 bits (543), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 59/271 (21%), Positives = 108/271 (39%), Gaps = 25/271 (9%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNK---PGQFLLRTSEPVKGEKRQFVLSVVGEKKTS 57
           +T  DL   +++   + R   +++L +    G FL+R S  V          +  E    
Sbjct: 251 LTRFDLEQNRWFCKDITRAKAEQLLRQAGSEGSFLVRESSQVGKLTVSVYSCIPCE---V 307

Query: 58  ANHFVVRE--SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTV-----KAVLKQAVE 110
             H+ V++  +      +K  F TI +L++++        T+         +      + 
Sbjct: 308 VKHYHVKQLPTGEWYLAEKHTFSTISDLIHYHQHNAAGLVTRLRHPVRPGEELPSTAGLS 367

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
             KWEL   ++   ++LG GA G V  G    +         +A++      + ++   +
Sbjct: 368 YGKWELDALELTSLRELGRGALGVVQLGMWRGVR-------HIAIRMLHEGVLAED---D 417

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYEL 228
              E +LM  L H N+V+ +GV     PL ++ME    G L + L             E 
Sbjct: 418 FFHEVKLMMQLSHPNLVQLYGVVTRYRPLRIVMEYLALGCLRTFLQARPGKLGSAWLLEA 477

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
                  + Y+   + +HRD+AAR+CL G  
Sbjct: 478 CSDVCKAMVYLESNSFLHRDLAARHCLVGED 508


>UniRef50_Q21292 Protein K07F5.4a, partially confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q21292_CAEEL
          Length = 517

 Score =  213 bits (542), Expect = 7e-54,   Method: Composition-based stats.
 Identities = 82/289 (28%), Positives = 137/289 (47%), Gaps = 38/289 (13%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVV---GEK 54
           + +  + + K YHG+  R+  ++ L    +PG FL R+     G      LSV    G+ 
Sbjct: 19  VGNSRVHNLKCYHGVRRRKKSRKNLMRGERPGTFLFRSCFVKSGVALALFLSVKVRAGDS 78

Query: 55  KTSANHFVVRESDHKVYV-------------DKIGFPTIIELVNHYVSTKESFSTKDGTV 101
             + +H+ V +   + Y+             +   FPT+ EL+ H+   + +        
Sbjct: 79  DANIHHYQVEDRAGEYYLMQELMEKEELVTRESKAFPTLEELIGHFQHHRLA-------C 131

Query: 102 KAVLKQAVERQKWELYHEDVELTK--KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAK 159
           K  L + ++R  W+L H  V      KLG G F  V++G L K      + + VA+K +K
Sbjct: 132 KIRLGRPLKRPSWQLRHNSVVYDDTGKLGSGNFCIVYRGMLRK----QGKIIPVAIKVSK 187

Query: 160 LESMTKEQIKE----IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL 215
                   + E    ++ EAR+M N ++INV++ +GVA    P  V ME   GG+L+ AL
Sbjct: 188 NSDKESAALMETRNLLLAEARIMMNYNNINVIRIYGVACDVPPFMVCMEFCSGGSLEDAL 247

Query: 216 GK--LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            K        ++  L+  AA G+ Y+H+K  +HRD+A+RNCL     ++
Sbjct: 248 KKYGKDMEEFERQILLIDAARGMRYLHDKKCVHRDLASRNCLISFDGIV 296


>UniRef50_B4DSE0 Ephrin receptor n=19 Tax=Euteleostomi RepID=B4DSE0_HUMAN
          Length = 928

 Score =  212 bits (541), Expect = 9e-54,   Method: Composition-based stats.
 Identities = 64/221 (28%), Positives = 106/221 (47%), Gaps = 15/221 (6%)

Query: 47  VLSVVGEKKTSANHFVVRE---SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKA 103
            ++V G K  +   F VR    + +  Y  K+ F T+ E+        + F+ +D     
Sbjct: 492 TVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEVTPGMKIYIDPFTYEDPN--- 548

Query: 104 VLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESM 163
              +AV     E+    V++ + +G G FGEV  G L        + + VA+KT K    
Sbjct: 549 ---EAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKL---PGKREIFVAIKTLK-SGY 601

Query: 164 TKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFP 221
           T++Q ++ + EA +M   DH NV+   GV   + P+ +I E  + G+LDS L +    F 
Sbjct: 602 TEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT 661

Query: 222 MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +I+   ++   A G+ Y+ + N +HRD+AARN L     V 
Sbjct: 662 VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVC 702


>UniRef50_B3XVX1 Protein tyrosine kinase syk (Fragment) n=1 Tax=Monosiga ovata
           RepID=B3XVX1_9EUKA
          Length = 835

 Score =  211 bits (537), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 79/302 (26%), Positives = 129/302 (42%), Gaps = 61/302 (20%)

Query: 13  HGLLPREDIQEMLN----KPGQFLLRTSEP------VKGEKRQFVLSVVGEKKTSANHFV 62
           +GLL R+  + +L     K G +L+R ++         G    FV+SV+ + +    H +
Sbjct: 113 YGLLGRDAAEALLQRLSPKDGSYLVRQTDKPTPDDRFPGAMAHFVVSVLHKGRGQ--HLL 170

Query: 63  VRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH-- 118
           +R+     Y   D + + T+ ELV+HY   ++    +      +L QA       +    
Sbjct: 171 IRKFPSGKYGIDDGLRYRTLAELVDHYRHGRDGLCCELRENVFLLDQARPNDAGRIISAI 230

Query: 119 ------------------------------------EDVELTKKLGEGAFGEVWKGKLLK 142
                                               + +  + KLGEG FG V KG L K
Sbjct: 231 KTRFAKLSAAAPAQSRSSSSSSLPKPASLESAVILSKYISTSTKLGEGEFGTVLKGVLTK 290

Query: 143 ILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVI 202
                  P+ VAVK  K+ +   E    + +EA  M NLDH NVV+  GV   +  L ++
Sbjct: 291 ---PGQSPIAVAVKALKIGADDNE----LRKEALTMVNLDHPNVVRMLGVCTDSPTLQLV 343

Query: 203 MELADGGALDSALG--KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
           +EL   GA++S L   +    + +    I Q A G+ Y+   +++HRD+AARN L G   
Sbjct: 344 VELLPNGAINSYLRAHETSIQLGQLMSFITQIAEGMLYLEGMHVIHRDLAARNVLVGERD 403

Query: 261 VL 262
           ++
Sbjct: 404 MV 405



 Score = 77.5 bits (190), Expect = 4e-13,   Method: Composition-based stats.
 Identities = 28/126 (22%), Positives = 57/126 (45%), Gaps = 3/126 (2%)

Query: 135 VWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAA 194
           V  G   +     +    V VK  + +   + ++ E++ +   ++   H N+V   G A+
Sbjct: 584 VCVGPYSRAFKGTYGRDPVIVKAMRQKREAR-KLSEVLAKIEGVQKAPHRNLVILHGPAS 642

Query: 195 GTE-PLYVIMELADGGALDSALGKLH-FPMIKKYELIYQAANGLAYIHEKNLMHRDVAAR 252
             +  L ++ E    G LD+ + +     +      I Q A+GLA++H+  ++H D+AAR
Sbjct: 643 LPDLGLVIVAEAVALGPLDAYIRRTPALTLDHCARFITQIASGLAFLHKHGIVHSDLAAR 702

Query: 253 NCLYGG 258
           +     
Sbjct: 703 HVFVAS 708


>UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n=1 Tax=Ciona intestinalis
           RepID=UPI000180C4D7
          Length = 525

 Score =  210 bits (536), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 68/266 (25%), Positives = 115/266 (43%), Gaps = 26/266 (9%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           +  +  ++++ G    ++ + ML   KPG +++  S+   G  R   L++         H
Sbjct: 146 EDSIECERWFFGKKSEKECERMLVQQKPGTYMITESKTEPGIYR-ISLTIQEALTLLVKH 204

Query: 61  FVV-RESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHE 119
             +    D      K  F     + N+    +     K G  +      +    WE+  E
Sbjct: 205 QTIPLPHDRHHKHHKQAF-----IGNYIGRAQRGSIMKYGEHEKPETSGIAPGDWEIGRE 259

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
            +   KKLG GAFGEVWKG   +          VA+K  +  +M+ E     ++EA +MR
Sbjct: 260 HLTQQKKLGAGAFGEVWKGGFHQ---------DVAIKELQPCTMSPEA---FLQEAEIMR 307

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIYQAANGL 236
            L H N+V  + V    EP+ ++ E    G+L   L       FP +   ++  Q A G+
Sbjct: 308 KLRHPNIVSIYAVIT--EPINIVTEFMCHGSLLDYLKDGPGSFFPFVDLIDMAAQIAAGM 365

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQVL 262
           A+I ++  +HRD+ A N L G  +V 
Sbjct: 366 AFIEQEKYIHRDLRADNVLVGENRVC 391


>UniRef50_Q4RVA1 Chromosome 15 SCAF14992, whole genome shotgun sequence n=1
           Tax=Tetraodon nigroviridis RepID=Q4RVA1_TETNG
          Length = 885

 Score =  209 bits (532), Expect = 9e-53,   Method: Composition-based stats.
 Identities = 52/179 (29%), Positives = 90/179 (50%), Gaps = 6/179 (3%)

Query: 86  HYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILD 145
           H+  +       D        +AV     E+    V++ + +G G FGEV+KG+L     
Sbjct: 386 HFSGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSTVKIEEVIGAGEFGEVYKGRLKL--- 442

Query: 146 ANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMEL 205
              + + VA+KT K   + ++Q ++ + EA +M   DH N+++  GV   + P+ ++ E 
Sbjct: 443 PGKREIYVAIKTLKSGYV-EKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEF 501

Query: 206 ADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + GALDS L +    F +I+   ++   + G+ Y+ E N +HRD+AARN L     V 
Sbjct: 502 MENGALDSFLRQNDGQFTVIQLVGMMRGISAGMKYLSEMNYVHRDLAARNILVNSNLVC 560


>UniRef50_UPI00005A03D8 PREDICTED: similar to Ephrin type-A receptor 2 precursor
           (Tyrosine-protein kinase receptor ECK) (Epithelial cell
           kinase) isoform 5 n=2 Tax=Euteleostomi
           RepID=UPI00005A03D8
          Length = 819

 Score =  208 bits (529), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 56/179 (31%), Positives = 88/179 (49%), Gaps = 6/179 (3%)

Query: 86  HYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILD 145
           HY   K   +  D        QAV +   E++   V   K +G G FGEV+KG L     
Sbjct: 422 HYGQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGTLKA--- 478

Query: 146 ANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMEL 205
           +  + V VA+KT K    T++Q  + + EA +M    H N+++  GV +  +P+ +I E 
Sbjct: 479 SGKKEVPVAIKTLKAG-YTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEY 537

Query: 206 ADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + GALD  L +    F +++   ++   A G+ Y+   N +HRD+AARN L     V 
Sbjct: 538 MENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVC 596


>UniRef50_UPI000194BA20 PREDICTED: EPH receptor A3 n=2 Tax=Euteleostomi RepID=UPI000194BA20
          Length = 1106

 Score =  207 bits (527), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 6/178 (3%)

Query: 87  YVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDA 146
           ++      +  D        QAV     EL   ++ + K +G G FGEV  G+L      
Sbjct: 710 HLKLPGLRTYVDPHTYEDPNQAVHEFAKELDASNISIDKVVGAGEFGEVCSGRLKL---P 766

Query: 147 NHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELA 206
           + + + VA+KT K+   T++Q ++ + EA +M   DH N+++  GV   ++P+ ++ E  
Sbjct: 767 SKKEISVAIKTLKVG-YTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYM 825

Query: 207 DGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + G+LDS L K    F +I+   ++   A+G+ Y+ +   +HRD+AARN L     V 
Sbjct: 826 ENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVC 883


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score =  206 bits (524), Expect = 7e-52,   Method: Composition-based stats.
 Identities = 59/275 (21%), Positives = 109/275 (39%), Gaps = 40/275 (14%)

Query: 7   LHQK--YYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
                 +YHG + RE  +++L     G FL+R S    G+   + L +    K    H+ 
Sbjct: 40  EQHPKLWYHGNITREHTEKILSGQADGTFLVRDSTNFPGD---YTLCMAFNGKVE--HYR 94

Query: 63  VRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ--------- 112
           + + +  +  D +  F  + +L+ HY    +    +  T        + R          
Sbjct: 95  IYQLNGILTCDHEETFDNLTQLIAHYKRDADGLCHRLITPVISDDYRITRDNESLEERIR 154

Query: 113 -----KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
                   +   ++ L   +G G FG+V  G        ++    VAVK  K      E 
Sbjct: 155 FFREASLIISRSEIRLGDIIGHGEFGDVLLG--------DYDGQRVAVKVLKRS----EM 202

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGT-EPLYVIMELADGGALDSALG---KLHFPMI 223
           ++ ++ EA+ M  L H+N+V   GV       ++++ E    G L + L    +     +
Sbjct: 203 VQSLLDEAKFMIGLKHVNLVALLGVVIDDAREMFMMTEYMANGNLANFLRSRGRHQVEKM 262

Query: 224 KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           +  +       G+ ++  KN++HRD+AARN L   
Sbjct: 263 QLTQFAIDICEGMKFLEIKNVVHRDLAARNVLLDD 297


>UniRef50_Q4SQX3 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SQX3_TETNG
          Length = 780

 Score =  206 bits (524), Expect = 8e-52,   Method: Composition-based stats.
 Identities = 58/195 (29%), Positives = 93/195 (47%), Gaps = 10/195 (5%)

Query: 74  KIGFPTIIELVNHYVSTKESFS----TKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
              F    E   HY +   SF       D        QAV     E+    +++ K +G 
Sbjct: 364 SKAFQDSDEEKMHYQNGHVSFPDARFYIDPHTYEDPCQAVHEFAREIEASRIKIEKIIGS 423

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           G FGEV  G++        + + VA+KT K+   T++Q ++ + EA +M   DH NV++ 
Sbjct: 424 GEFGEVCYGRMRL---PGKRDIPVALKTLKVG-YTEKQKRDFLAEASIMAQFDHPNVIRL 479

Query: 190 FGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHR 247
            GV   ++P+ +I E  + G+LDS L +    F +I+   L+   A G+ Y+ +   +HR
Sbjct: 480 EGVVTHSKPVMIITEYMENGSLDSFLRRHDGQFTIIQLVGLLRGIAAGMTYLSDLGYIHR 539

Query: 248 DVAARNCLYGGGQVL 262
           D+AARN L     V 
Sbjct: 540 DLAARNILVNSNLVC 554


>UniRef50_A8XT57 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8XT57_CAEBR
          Length = 579

 Score =  206 bits (524), Expect = 8e-52,   Method: Composition-based stats.
 Identities = 70/297 (23%), Positives = 120/297 (40%), Gaps = 51/297 (17%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           L H  +YHG++    ++++L     +L+R +      K+   +SV  + K         E
Sbjct: 66  LKHHLWYHGMMFGGTVEKLLKWEHSYLVRRAIQRSSMKKTLCISVKIDGKVLNFQLTWNE 125

Query: 66  SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTK 125
                      FP + +    Y    +       +V A+    V R +  L+H  + L  
Sbjct: 126 DGWGSTKLVAKFPKMAQ--KRYAHIYQLLDAWSLSVNAIT--PVPRNRIVLHHSSITLGN 181

Query: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
           KLG GAFGEV++ K L   +   + + VAVK A +    +  I+E   EA++M  L H+N
Sbjct: 182 KLGSGAFGEVYRAKYL--PNGASESIEVAVKRA-IGDAQRSTIQEFCHEAQVMGVLQHVN 238

Query: 186 VVKFFGVAAGTEPLYVIMELADGGALD--------------------------------- 212
           +V  +G+A+  +P+ ++MEL  GG L                                  
Sbjct: 239 IVCLYGIASLEQPVMLVMELVTGGDLRLCREMLLNTFRDAHALNFEGAEINTHFRYMNNP 298

Query: 213 ----------SALGKLH-FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
                       L   H     +        A+G+ ++ ++ ++HRD+AARNCL   
Sbjct: 299 IRFPNSLKFQKHLQTTHNISHRQLITFAADIASGMKHMAQRRVIHRDLAARNCLITN 355


>UniRef50_Q9N3S5 Putative uncharacterized protein n=4 Tax=Caenorhabditis
           RepID=Q9N3S5_CAEEL
          Length = 618

 Score =  206 bits (524), Expect = 9e-52,   Method: Composition-based stats.
 Identities = 65/284 (22%), Positives = 110/284 (38%), Gaps = 46/284 (16%)

Query: 8   HQKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
            + ++ G +     ++ + +P    G FL+R +         FVL V      S   +++
Sbjct: 200 REPWFAGNISSILAEQRVMQPQLPIGSFLIRENSKTD----TFVLVVRSSHNESPQAYII 255

Query: 64  RESDHKVYVDKI--------GFPTIIELVNHYVSTKES----FSTKDGTVKAVLKQAVER 111
               ++   +           F ++ +LVNHY   K        TK       L +  E 
Sbjct: 256 YRRPNQEGFEIRDNHRPAVIHFGSLHQLVNHYSCEKVPGEIQICTKLTKAAPPLPEQTEY 315

Query: 112 QKW---ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
                  +   +V   K++G G FGEV+  K           V VAVK+ K +   +   
Sbjct: 316 MAMKKIHVNRSEVRRVKEIGRGQFGEVYLAKWKG--------VDVAVKSLKPDHSEQLAN 367

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKK--- 225
            + + EA+ +  L H NV+    V    +P  +I E    G+L + L KL   +      
Sbjct: 368 TQFLEEAKTLTKLSHQNVIHLLAVCDTDKPYLIITEFMTNGSLLAWLQKLTKTLPPIPLM 427

Query: 226 ------------YELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
                         +  Q A+G+ Y+    ++HRD+AARN L G
Sbjct: 428 SEETGRKNVLIGASISAQVASGMDYLSANKIVHRDLAARNVLVG 471


>UniRef50_Q6PFV6 Ephrin receptor n=8 Tax=Amniota RepID=Q6PFV6_MOUSE
          Length = 819

 Score =  205 bits (522), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 49/178 (27%), Positives = 87/178 (48%), Gaps = 6/178 (3%)

Query: 87  YVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDA 146
           ++      +  D        QAV     E+    + + + +G G FGEV  G+L      
Sbjct: 457 HIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKL---P 513

Query: 147 NHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELA 206
             + + VA+KT K+   T++Q ++ + EA +M   DH N++   GV   ++P+ ++ E  
Sbjct: 514 GKRELPVAIKTLKVG-YTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYM 572

Query: 207 DGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + G+LD+ L K    F +I+   ++   A G+ Y+ +   +HRD+AARN L     V 
Sbjct: 573 ENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVC 630


>UniRef50_P29323 Ephrin type-B receptor 2 n=364 Tax=Eumetazoa RepID=EPHB2_HUMAN
          Length = 1055

 Score =  204 bits (521), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 56/184 (30%), Positives = 88/184 (47%), Gaps = 9/184 (4%)

Query: 84  VNHYVS---TKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKL 140
           + HY S   T       D        +AV     E+    V++ + +G G FGEV  G L
Sbjct: 581 LQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHL 640

Query: 141 LKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLY 200
                   + + VA+KT K    T++Q ++ + EA +M   DH NV+   GV   + P+ 
Sbjct: 641 KL---PGKREIFVAIKTLK-SGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVM 696

Query: 201 VIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           +I E  + G+LDS L +    F +I+   ++   A G+ Y+ + N +HRD+AARN L   
Sbjct: 697 IITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS 756

Query: 259 GQVL 262
             V 
Sbjct: 757 NLVC 760


>UniRef50_Q07497 Ephrin type-B receptor 5 n=68 Tax=Euteleostomi RepID=EPHB5_CHICK
          Length = 1002

 Score =  204 bits (520), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 53/187 (28%), Positives = 91/187 (48%), Gaps = 10/187 (5%)

Query: 81  IELVNHYVSTKESFSTK---DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWK 137
            + +  Y+ST+     K   D +      +A+     E+    +++ + +G G FGEV  
Sbjct: 595 TDRLQQYISTR-GLGVKYYIDPSTYEDPNEAIREFAKEIDVSFIKIEEVIGSGEFGEVCF 653

Query: 138 GKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE 197
           G+L        +   VA+KT K    T EQ +E + EA +M   +H NV+   GV   + 
Sbjct: 654 GRLK---HPGKREYTVAIKTLK-SGYTDEQRREFLSEASIMGQFEHPNVIHLEGVVTKSR 709

Query: 198 PLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
           P+ ++ E  + G+LDS L +    F +++   ++   A G+ Y+ + N +HRD+AARN L
Sbjct: 710 PVMIVTEFMENGSLDSFLRQKEGQFSVLQLVGMLRGIAAGMRYLSDMNYVHRDLAARNIL 769

Query: 256 YGGGQVL 262
                V 
Sbjct: 770 VNSNLVC 776


>UniRef50_A8XI09 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8XI09_CAEBR
          Length = 468

 Score =  204 bits (519), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 79/251 (31%), Positives = 129/251 (51%), Gaps = 17/251 (6%)

Query: 19  EDIQEMLNKPGQFLLRTSEPVKGEKRQF-VLSVVGEKKTSANHFVVRESDHK-----VYV 72
            D +  L   G +LLR +EP +G   QF V+SV  E      H  + +          ++
Sbjct: 56  HDAEMSLRYVGDYLLRRAEPTEGIGGQFLVISVKREGGFV--HVPLSQDREGPLKQFYFM 113

Query: 73  DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAF 132
             +   +++ +++ +++          T  A L++ V R  W + HEDV L KK+G GAF
Sbjct: 114 PTVKDTSVLSVIDGHLARGLPICI---TWNAYLRKPVNRSTWLIAHEDVILYKKIGSGAF 170

Query: 133 GEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFG 191
           GEV+  +++     +   +  AVK  K+E+    +++  M+EAR+MR    H +VV  FG
Sbjct: 171 GEVFLARMVD--PTSEYVLDCAVKKLKMEATMDAKLR-FMKEARMMRKCYKHKHVVMIFG 227

Query: 192 VAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
           +A    PL ++MEL   G+L S L K      ++ K     +A++GLA++ + N +HRDV
Sbjct: 228 IATLNSPLLILMELCPNGSLVSHLRKNKGKVTVLDKLRFSAEASSGLAHLEKMNCIHRDV 287

Query: 250 AARNCLYGGGQ 260
           AARNCL     
Sbjct: 288 AARNCLLSSKN 298


>UniRef50_UPI0001757DA5 PREDICTED: similar to insulin receptor, partial n=1 Tax=Tribolium
            castaneum RepID=UPI0001757DA5
          Length = 1450

 Score =  204 bits (519), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 63/259 (24%), Positives = 110/259 (42%), Gaps = 35/259 (13%)

Query: 27   KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIGFPTIIELV-- 84
             PG + +R S    G+   F         +   +F + E     YV  I    I+ ++  
Sbjct: 985  SPGNYSVRVSATTSGDYANF---------SPYAYFYIEERPSNTYVTLIVCMLILVIILA 1035

Query: 85   -------NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWK 137
                       + KES           +       +WE+  + +EL ++LG+G+FG V++
Sbjct: 1036 LCAFCFYKKKKADKESMRLIPSVNPEYVPSVYVPDEWEVPRKKIELIRELGQGSFGMVYE 1095

Query: 138  GKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE 197
            G    +       +  AVKT    +  +E++ E + EA +M+  D  +VV+  GV +  +
Sbjct: 1096 GIAQDVR--GKAQIKCAVKTVNEHATNRERL-EFLNEASVMKAFDTAHVVRLLGVVSQGQ 1152

Query: 198  PLYVIMELADGGALDSALG--------------KLHFPMIKKYELIYQAANGLAYIHEKN 243
            P  VIMEL   G L + L               K    + +  ++  + A+G+AY+  K 
Sbjct: 1153 PTLVIMELMANGDLKTYLRSHRPDAEVYDPATAKQPPTLKQILQMAIEIADGMAYLSAKK 1212

Query: 244  LMHRDVAARNCLYGGGQVL 262
             +HRD+AARNC+      +
Sbjct: 1213 FVHRDLAARNCMVAEDLTV 1231


>UniRef50_Q4T272 Chromosome undetermined SCAF10323, whole genome shotgun sequence.
           (Fragment) n=2 Tax=Tetraodontidae RepID=Q4T272_TETNG
          Length = 815

 Score =  203 bits (518), Expect = 4e-51,   Method: Composition-based stats.
 Identities = 51/167 (30%), Positives = 88/167 (52%), Gaps = 6/167 (3%)

Query: 98  DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT 157
           D        QAV +   E++   + + + +G G FGEV  G L        + +LVA+KT
Sbjct: 455 DPLTYEDPNQAVHQFAQEIHLSSISIERIIGAGEFGEVCSGPLRL---PGKREILVAIKT 511

Query: 158 AKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK 217
            K    T++Q ++ + EA +M   +H N+++  GV   ++P+ +I E  + G+LD+ L K
Sbjct: 512 LKAG-YTEQQRRDFLWEASIMGQFNHPNIIRLEGVVTKSKPVMIITEYMENGSLDTFLKK 570

Query: 218 L--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               F +I+   ++   A+G+ Y+ +   +HRD+AARN L  G  V 
Sbjct: 571 NDGQFTVIQLVGMLRGIASGMRYLSDMGYVHRDLAARNILVDGHLVC 617


>UniRef50_P54756 Ephrin type-A receptor 5 n=102 Tax=Euteleostomi RepID=EPHA5_HUMAN
          Length = 1037

 Score =  203 bits (517), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 48/178 (26%), Positives = 87/178 (48%), Gaps = 6/178 (3%)

Query: 87  YVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDA 146
           ++      +  D        QAV     E+    + + + +G G FGEV  G+L      
Sbjct: 641 HIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKL---P 697

Query: 147 NHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELA 206
             + + VA+KT K+   T++Q ++ + EA +M   DH N++   GV   ++P+ ++ E  
Sbjct: 698 GKRELPVAIKTLKVG-YTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYM 756

Query: 207 DGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + G+LD+ L K    F +I+   ++   + G+ Y+ +   +HRD+AARN L     V 
Sbjct: 757 ENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVC 814


>UniRef50_Q4RV12 Ephrin receptor (Fragment) n=3 Tax=Euteleostomi RepID=Q4RV12_TETNG
          Length = 1006

 Score =  203 bits (516), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 49/167 (29%), Positives = 83/167 (49%), Gaps = 6/167 (3%)

Query: 98  DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT 157
           D        QA+     E+    + + + +G G FGEV  G+L        + + VA+K+
Sbjct: 638 DPFTYEDPDQAIHEFAKEIDVSSIHIERVIGMGEFGEVCSGRLR---VQGKREIYVAIKS 694

Query: 158 AKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK 217
            K     K Q ++ + EA +M   DH N+++  GV    +PL +I E  + G+LD+ L K
Sbjct: 695 LKAGYSDK-QRRDFLSEASIMGQFDHPNIIRLEGVVTRCKPLMIITEYMENGSLDAFLRK 753

Query: 218 L--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               F +I+   ++   A+G+ Y+ + + +HRD+AARN L     V 
Sbjct: 754 HDGQFTVIQLVGMLRGIASGMKYLSDMSYVHRDLAARNILVNSNLVC 800


>UniRef50_Q9Y1Y3 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y3_9METZ
          Length = 893

 Score =  201 bits (513), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 53/167 (31%), Positives = 79/167 (47%), Gaps = 7/167 (4%)

Query: 98  DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT 157
           D        QAV     E+  + ++L +++G G FG V+KG      +    PV +AVKT
Sbjct: 512 DPRTYQSTTQAVSTVATEIPPKYIKLVEEIGGGEFGTVYKGMW----NERKPPVPIAVKT 567

Query: 158 AKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK 217
            K  S  K    + + EA +M    H NV+K +GV    EP  +IME  D G+L   L  
Sbjct: 568 LKPGSSDK-MRDDFLTEASIMGQFHHPNVIKLYGVITKVEPAMIIMEFMDNGSLYYYLRH 626

Query: 218 L--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                 + +  ++    A G+ Y+ E   +HRD+AARN L    +V 
Sbjct: 627 NDEKLSLQQLLKMACGVAAGMQYLSEVGYVHRDLAARNILVSKDEVC 673


>UniRef50_P29317 Ephrin type-A receptor 2 n=31 Tax=Euteleostomi RepID=EPHA2_HUMAN
          Length = 976

 Score =  201 bits (513), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 57/205 (27%), Positives = 94/205 (45%), Gaps = 12/205 (5%)

Query: 60  HFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHE 119
           H   +    +   + + F    +L       K   +  D        QAV +   E++  
Sbjct: 559 HRRRKNQRARQSPEDVYFSKSEQL-------KPLKTYVDPHTYEDPNQAVLKFTTEIHPS 611

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
            V   K +G G FGEV+KG L     +  + V VA+KT K    T++Q  + + EA +M 
Sbjct: 612 CVTRQKVIGAGEFGEVYKGMLKT--SSGKKEVPVAIKTLKAG-YTEKQRVDFLGEAGIMG 668

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLA 237
              H N+++  GV +  +P+ +I E  + GALD  L +    F +++   ++   A G+ 
Sbjct: 669 QFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMK 728

Query: 238 YIHEKNLMHRDVAARNCLYGGGQVL 262
           Y+   N +HRD+AARN L     V 
Sbjct: 729 YLANMNYVHRDLAARNILVNSNLVC 753


>UniRef50_C4PYF4 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYF4_SCHMA
          Length = 855

 Score =  201 bits (512), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 71/341 (20%), Positives = 128/341 (37%), Gaps = 99/341 (29%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGE-----K 54
              L    +Y+  + R+  + +L   N+ G FL+R S      K  + LSV  +      
Sbjct: 369 PNSLNSFDWYYKDITRQQAEAILLDENREGCFLVRDSVSK---KNTYTLSVTSKDPEAPG 425

Query: 55  KTSANHFVVRESD----------------------------------------------H 68
           K   +H+ +  ++                                              +
Sbjct: 426 KLKVHHYHIHRTESSSLNGHLNGCGVGSGSGSNSGLNSTASVAATSITVTTTTNTIVNMN 485

Query: 69  KVYVDKIGFPTIIELVN----HYVSTKESFST----------KDGTVKAVLKQAVER--- 111
                    P +   +N    +Y+S K +F T            G +   L+    +   
Sbjct: 486 GSTGTGSNTPKVGSTINGEAQYYLSEKHAFPTISDVIHYHKHNSGGLVVRLRSPPTKDRE 545

Query: 112 ---------QKWELYHEDVELTKK-LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLE 161
                     ++EL   ++ L ++ +G+G FG V +GK           + VAVK     
Sbjct: 546 SPVTAGMGLDEFELDPAELHLEREPIGKGQFGVVKRGKFRN--------IPVAVKQMVEG 597

Query: 162 SMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP 221
           +M ++   + + EA+ MR L+H N+V+ FGV     P+ +I E    G+L   + +    
Sbjct: 598 AMNED---DFIEEAKNMRFLNHPNLVQLFGVVLKKRPIMIITEYMKHGSLRDFMRQRQTQ 654

Query: 222 MIKK----YELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
              +     ++  Q ANG+AY+ ++  +HRD+AARNCL   
Sbjct: 655 FCNRPVVMSDICAQVANGMAYLEQEQFVHRDLAARNCLVKS 695


>UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYM5_SCHMA
          Length = 670

 Score =  200 bits (510), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 70/309 (22%), Positives = 118/309 (38%), Gaps = 67/309 (21%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVG--------- 52
           ++L    +YHG + R + + +L+    G FL+R S+   G      L VVG         
Sbjct: 76  ENLKDHCWYHGRISRAESESLLSGSPVGSFLIRESDLYSG---GLTLCVVGPACAVGSPD 132

Query: 53  ------------EKKTSANHFVVRESDHKVY---------------------VDKIGFPT 79
                          T+  H+ +     K                        +   F +
Sbjct: 133 TTEHQNSTVTPPNTMTNVQHYRIVRRPFKATPSNQHSEYSTPLICSKIHYTLDETDWFSS 192

Query: 80  IIELVNHYVSTKESFSTKDGTVKAVLKQA----VERQKWELYHEDVELTKKLGEGAFGEV 135
           ++ELV  Y   K             +++     +++  + ++ +++ L  ++G G FGEV
Sbjct: 193 LLELVQFYSEPKRGLVCALLHPVPDMQRKRLSELQKFGYLIFRKEIALGDRIGRGEFGEV 252

Query: 136 WKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFG-VAA 194
            K               VAVK  K  +        I  EA LM  L+H N+V F G V  
Sbjct: 253 LKATYRGR--------QVAVKIYKKTAS----KLAITYEASLMTKLNHPNLVSFIGLVYE 300

Query: 195 GTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAA 251
             + +Y+I E    G+L + L    +     + K +       GL Y+ E++ +HRD+AA
Sbjct: 301 PDDAVYLITEYLSNGSLLTYLHSRTRDEITELTKLKFSIDVCRGLVYLEERDFIHRDIAA 360

Query: 252 RNCLYGGGQ 260
           RN L  G +
Sbjct: 361 RNVLLSGQK 369


>UniRef50_UPI0000E47549 PREDICTED: similar to Cek8 n=2 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E47549
          Length = 775

 Score =  199 bits (508), Expect = 6e-50,   Method: Composition-based stats.
 Identities = 54/201 (26%), Positives = 94/201 (46%), Gaps = 12/201 (5%)

Query: 64  RESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
            E+ H +Y +      I+  +    +  + F+ +D        QAV+    E+    + +
Sbjct: 366 SENGHLIYANGTNGEVILPHIKKVKTYVDPFTYEDPN------QAVKEFATEIDATQIRI 419

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
            + +G G FG+V  G +L     +   + VAVKT K  +  K++  + + EA +M   DH
Sbjct: 420 LEVIGGGEFGDVCSGLML---MPDKTTIKVAVKTLKTGATDKDR-SDFLSEASIMGQFDH 475

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHE 241
            NV+K  GV   T P  ++ E  + G+LD  L +    F + +   ++     G+ ++ E
Sbjct: 476 PNVIKLLGVVTKTRPAMIVTEFMENGSLDKYLRENDGRFTVTQLLGMMRGVGFGMRFLSE 535

Query: 242 KNLMHRDVAARNCLYGGGQVL 262
            N +HRD+AARN L     V 
Sbjct: 536 MNFVHRDLAARNILVNEHLVC 556


>UniRef50_Q8I4A8 Protein ZK20.2, partially confirmed by transcript evidence n=2
           Tax=Caenorhabditis elegans RepID=Q8I4A8_CAEEL
          Length = 365

 Score =  199 bits (507), Expect = 8e-50,   Method: Composition-based stats.
 Identities = 82/230 (35%), Positives = 129/230 (56%), Gaps = 28/230 (12%)

Query: 39  VKGEKRQFVLSVVGEKKTS------ANHFVVRE--SDHKVY-VDKIGFPTIIELVNHYVS 89
              + R ++LSV      S       N  +++E   + K+Y +    F +I ++VNHY++
Sbjct: 2   FPNDGRHYILSVKHNSPPSPDLVPIINMVIMQEVVCNRKMYSIQCKCFESIQQMVNHYLT 61

Query: 90  TKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQ 149
           TKE  S+      A L +AV RQ WEL H+++ + ++L +GAF E+  G+L      + +
Sbjct: 62  TKELISSIYS--SAHLIKAVPRQHWELDHKNIFIQQRLRDGAFEEIMMGQLK--CRNSGK 117

Query: 150 PVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGG 209
            + VA+K  K+ ++TK+QIKE M+EAR+M                 TEPLY++ ELA  G
Sbjct: 118 MIHVAIKKTKMRNLTKDQIKEFMQEARVM---------------PTTEPLYIVTELAFHG 162

Query: 210 ALDSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
            LD+ L K    + +K E+  QAA G+ Y+H K ++HRD+AARN +YG  
Sbjct: 163 PLDNYLKKNELSIDRKNEMTLQAAWGIEYLHSKPVIHRDIAARNFVYGYN 212


>UniRef50_B7QJ81 Eph receptor tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7QJ81_IXOSC
          Length = 902

 Score =  199 bits (506), Expect = 9e-50,   Method: Composition-based stats.
 Identities = 54/178 (30%), Positives = 84/178 (47%), Gaps = 6/178 (3%)

Query: 87  YVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDA 146
           + +   S +  D        QAV     E+    + +   +G G FG+V +GKL      
Sbjct: 506 HCTGAASRAYVDPHTYEDPNQAVREFTKEIDALHITIEAIIGGGEFGDVCRGKLKC---P 562

Query: 147 NHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELA 206
               V VA+KT K  S  K ++ + + EA +M   DH NV+   GV   + P+ +I E  
Sbjct: 563 GRPEVTVAIKTLKPGSSDKARM-DFLTEASIMGQFDHPNVIFLQGVVTKSNPIMIITEYM 621

Query: 207 DGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + G+LD+ L      F +I+   ++   A G+ Y+ E N +HRD+AARN L     V 
Sbjct: 622 ENGSLDTFLRANDGKFQVIQLVGMLRGIAAGMQYLAEMNYVHRDLAARNVLVNANLVC 679


>UniRef50_Q4SUM3 Ephrin receptor (Fragment) n=5 Tax=Tetraodontidae
           RepID=Q4SUM3_TETNG
          Length = 1173

 Score =  199 bits (506), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 52/167 (31%), Positives = 85/167 (50%), Gaps = 6/167 (3%)

Query: 98  DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT 157
           D        +AV     E+    V++ + +G G FGEV  G L +      + +LVA+KT
Sbjct: 638 DPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGNLRQ---PGKREILVAIKT 694

Query: 158 AKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK 217
            K+   T+ Q ++ + EA +M   DH N++   GV   + P+ +I E  + G+LDS L +
Sbjct: 695 LKVG-YTERQRRDFLSEASIMGQFDHPNIIHLEGVVTKSSPVMIITEFMENGSLDSFLRQ 753

Query: 218 L--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               F +I+   ++   A G+ Y+ + N +HRD+AARN L     V 
Sbjct: 754 NDGQFTVIQLVGMLRGIAAGVKYLCDMNYVHRDLAARNILVNSNLVC 800


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score =  198 bits (505), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 59/219 (26%), Positives = 101/219 (46%), Gaps = 25/219 (11%)

Query: 56  TSANHFVVRESDHKVYVDKIGFP-TIIELVNH--------YVSTKESFSTKDGTVKAVLK 106
              N F V    H+   +   FP T I  V+H        +++  E  S    ++ ++  
Sbjct: 359 PGPNQFEVNPIVHQSNAEISNFPLTHINPVSHVPRPFHPSHINNSERLSAYSDSIGSM-- 416

Query: 107 QAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKE 166
              E   WE+   ++ + +KLG G +G+V++    +         +VAVKT K +     
Sbjct: 417 ---EFDGWEIDRPEIIMRQKLGCGQYGDVYEAVWKRFNS------VVAVKTLKQDVNLN- 466

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMI 223
            + + ++EA +M+ L + N+V+  GV     PLY+I E    G L + L          +
Sbjct: 467 -VNDFLKEAAIMKKLRNRNLVQLLGVCTRELPLYLITEYMPNGNLLNYLRTRSPGELTPL 525

Query: 224 KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               +  Q A+G+AY+   N +HRD+AARNCL G   ++
Sbjct: 526 TLLYMAVQIASGMAYLEANNFIHRDLAARNCLVGDQHLI 564



 Score = 90.2 bits (223), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 24/111 (21%), Positives = 47/111 (42%), Gaps = 11/111 (9%)

Query: 9   QKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
             +YHG + R+  + +L     G FL+R SE   G+     LSV         H+ + + 
Sbjct: 239 YSWYHGAVSRQAGEHLLRSGITGSFLVRASESAPGQ-----LSVTVRHLGRVYHYRISQD 293

Query: 67  DHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWE 115
              ++   +   FPT+++L+ H+  + +        + +V K     Q  +
Sbjct: 294 SRGLFYITEAHRFPTVVQLIEHHSRSADGLVC--PLLYSVPKPQFLNQPMQ 342


>UniRef50_Q4SP88 Ephrin receptor (Fragment) n=4 Tax=Euteleostomi RepID=Q4SP88_TETNG
          Length = 950

 Score =  198 bits (505), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 54/167 (32%), Positives = 85/167 (50%), Gaps = 6/167 (3%)

Query: 98  DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT 157
           D         AV     E+    V++ + +G G FGEV +G+L +   A  + ++VA+KT
Sbjct: 613 DPFTYEDPNDAVHEFAKEIDISCVKIEEVIGAGEFGEVCRGRLKQ---AGRREMVVAIKT 669

Query: 158 AKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG- 216
            K    T+ Q ++ + EA +M   DH NV++  GV   + P+ +I E  + GALDS L  
Sbjct: 670 LKAG-YTERQRRDFLAEASIMGQFDHPNVIRLEGVLTRSCPVLIITEFMENGALDSFLRL 728

Query: 217 -KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               F M +   ++   A G+ Y+ + N +HRD+AARN L     V 
Sbjct: 729 NDGRFTMTQLVGMLRGVAAGMKYLSDMNYVHRDLAARNILVNSNLVC 775


>UniRef50_UPI0000DB7426 PREDICTED: similar to insulin-like growth factor 1 receptor isoform 1
            n=1 Tax=Apis mellifera RepID=UPI0000DB7426
          Length = 1422

 Score =  198 bits (503), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 66/265 (24%), Positives = 118/265 (44%), Gaps = 28/265 (10%)

Query: 16   LPREDIQEMLNKPG---QFLLRTSEPVKGEKRQFVLSVVGEKK-TSANHFVVRESDH--- 68
            +PR   Q      G    +L+R   P K   R    S+ G+ + +   HF +  +D    
Sbjct: 975  IPRSLAQP--RTDGGSSSYLIRNLSPGKYSLRMRSTSLAGDGRFSDVVHFSIDLADSAPV 1032

Query: 69   ----KVYVDKIGFPTIIELV--NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
                 + +  +   +++  V   H+   K             ++      +WE+  E VE
Sbjct: 1033 TLVALLVLCVLAMMSVVLFVVWRHHRKRKNQERLIASVNPDYIETKYVIDEWEVPRESVE 1092

Query: 123  LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
            ++ +LG G FG V++G   K        + VA+KT    +  +E+  E + EA +M+N  
Sbjct: 1093 ISNELGLGNFGMVYRGVYDKT-------IPVAIKTISKTASQREK-NEFLNEASVMKNFS 1144

Query: 183  HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI-----KKYELIYQAANGLA 237
              +++K  GV +   P +VIMEL + G L + L ++    +     +   +  + A+G+A
Sbjct: 1145 TFHIIKLIGVVSIENPPFVIMELMENGDLKTYLRRIRDTRLVPDTCRIMRMAAEIADGMA 1204

Query: 238  YIHEKNLMHRDVAARNCLYGGGQVL 262
            Y+  K  +HRD+AARNC+     V 
Sbjct: 1205 YLESKKYVHRDLAARNCMVSKDLVC 1229


>UniRef50_UPI000180C9B0 PREDICTED: ephrin receptor gamma n=1 Tax=Ciona intestinalis
           RepID=UPI000180C9B0
          Length = 1062

 Score =  197 bits (502), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 50/170 (29%), Positives = 86/170 (50%), Gaps = 6/170 (3%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           +  D T     ++AV     E+    +++ + +G G FGEV +G+L      N     VA
Sbjct: 622 TYIDPTTYEDPQRAVSEFTKEIDATYIKIEQVIGAGEFGEVCRGRLQL---PNKPESDVA 678

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           +KT K    T++++ + + EA +M   DH NV++  GV   + PL +I E  + G+LD+ 
Sbjct: 679 IKTLKTGYSTQQKL-DFLGEASIMGQFDHPNVIRLEGVVTKSRPLMIITEFMENGSLDAF 737

Query: 215 LGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L      F +I+   ++   A G+ Y+ +   +HRD+AARN L     + 
Sbjct: 738 LRNHDNGFTVIQLVGILRNIAAGMKYLSDMGYVHRDLAARNILVNAQLIC 787


>UniRef50_Q4H3M7 Ephrin receptor n=3 Tax=Ciona RepID=Q4H3M7_CIOIN
          Length = 1006

 Score =  197 bits (501), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 14/179 (7%)

Query: 89  STKESFSTK---DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILD 145
           S+ +  ST+   D +       AV+    E+  + V + + +G G FGEV KG       
Sbjct: 611 SSVDLLSTRTYVDPSTYEDPYNAVKEFAKEIDFKLVNIEQVIGRGEFGEVCKGTFFNKC- 669

Query: 146 ANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMEL 205
                  VA+KT K+   T+E+  + + EA +M   DH NV++  GV   + PL +I E 
Sbjct: 670 -------VAIKTLKVGYNTQER-SDFLGEASIMGQFDHPNVIRLEGVVTKSRPLMIITEF 721

Query: 206 ADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + G+LD+ L       P  +  E++   A G+ Y+     +HRD+AARN L     V 
Sbjct: 722 MENGSLDAFLRNQEGKIPSAQLTEMLLSIAQGMEYLSNMGYVHRDLAARNILVNSNLVC 780


>UniRef50_P42687 Tyrosine-protein kinase SPK-1 n=1 Tax=Girardia tigrina
           RepID=SPK1_DUGTI
          Length = 497

 Score =  196 bits (500), Expect = 4e-49,   Method: Composition-based stats.
 Identities = 58/264 (21%), Positives = 110/264 (41%), Gaps = 33/264 (12%)

Query: 16  LPREDIQEMLNK----PGQFLLRTSEPVKGEKRQFVLSVVG----EKKTSANHFVVR--- 64
           + R + ++ L K     G +++R S     ++  + LSV      +K     HF ++   
Sbjct: 105 IQRWEAEKSLMKIGLQKGTYIIRPSR----KENSYALSVRDFDEKKKICIVKHFQIKTLQ 160

Query: 65  -ESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAV--LKQAVERQKWELYHEDV 121
            E      V+   FP I+ L+  Y       +    T       +  V  Q  E+  E++
Sbjct: 161 DEKGISYSVNIRNFPNILTLIQFYEKNGIGNTHIPLTDPMPDNYQPPVHFQDIEINRENI 220

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
           E+  ++G G FG V + K         +   VA K       +K + ++ + EA++M  L
Sbjct: 221 EILNEIGRGFFGSVHRAKW-------GRSYEVAAKML---QSSKAEREKFVLEAKIMHKL 270

Query: 182 DHINVVKFFGVAAGTE--PLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAANGL 236
            H  +V+  GV    +  P+ +I+E    G+L   L         + +   ++ + + G+
Sbjct: 271 RHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGM 330

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQ 260
           AY+  + ++HRD+ A N L     
Sbjct: 331 AYLESEKVVHRDLRADNILVANDL 354


>UniRef50_Q5D184 Ephrin receptor n=5 Tax=Neoptera RepID=Q5D184_APIME
          Length = 996

 Score =  195 bits (497), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 52/170 (30%), Positives = 83/170 (48%), Gaps = 4/170 (2%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           S  D        QAV     E+    + +   +G G FG+V +GKL K+       + VA
Sbjct: 607 SYVDPHTYEDPNQAVREFAREIDAGYITIEAIIGGGEFGDVCRGKL-KLPPDGRTEIDVA 665

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           +KT K  S  K +  + + EA +M   +H NV+   GV   + P+ +I E  + G+LD+ 
Sbjct: 666 IKTLKPGSADKAR-NDFLTEASIMGQFEHPNVIFLQGVVTKSNPVMIITEFMENGSLDTF 724

Query: 215 LGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L      F +++   ++   A+G+ Y+ E N +HRD+AARN L     V 
Sbjct: 725 LRANDGKFQVLQLVGMLRGIASGMQYLAEMNYVHRDLAARNVLVNAALVC 774


>UniRef50_C4XV89 Venus kinase receptor (Fragment) n=2 Tax=Pediculus humanus corporis
           RepID=C4XV89_9NEOP
          Length = 1154

 Score =  195 bits (496), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 55/173 (31%), Positives = 89/173 (51%), Gaps = 18/173 (10%)

Query: 104 VLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESM 163
           +L   ++  KWE+  + + + +KLGEGAFG V+ G+      ++   V  AVK  K+ S 
Sbjct: 830 LLAPNLDSDKWEIPRDRLVINRKLGEGAFGTVYGGEAY---FSDKGWVAAAVKALKVNST 886

Query: 164 TKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL-------- 215
           T++++ + + EA +M+  DH N+VK  GV    EP+Y +ME    G L + L        
Sbjct: 887 TEQKL-DFLSEAEVMKKFDHKNIVKLLGVCTKQEPVYTVMEFMLYGDLKTFLLARRHLVN 945

Query: 216 -GKLH-----FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             K+H         K   +    A GL+Y+ +   +HRD+A RNCL    +V+
Sbjct: 946 NKKIHEESDEISSKKLTAMALDVARGLSYLAQLKYVHRDIACRNCLINYARVV 998


>UniRef50_Q4H3M4 Ephrin receptor n=1 Tax=Ciona intestinalis RepID=Q4H3M4_CIOIN
          Length = 1048

 Score =  194 bits (495), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 49/170 (28%), Positives = 86/170 (50%), Gaps = 5/170 (2%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           +  D T      +AV     E+    + + + +G G FGEV  G++   L  + +   VA
Sbjct: 617 TYIDPTTYEDPARAVLDFTKEIDASYIGIEEVIGGGEFGEVCLGRMR--LPNSKKEHDVA 674

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           +KT K    T++++ + + EA +M   DH NV++  GV   ++P  +I E  + G+LD+ 
Sbjct: 675 IKTLKAGYSTQQKL-DFLGEASIMGQFDHPNVIRLEGVVTKSQPHMIITEYMENGSLDTF 733

Query: 215 LGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L K    F +I+   ++   A G+ Y+ +   +HRD+AARN L     + 
Sbjct: 734 LRKHDGEFTVIQLVGILRNIAAGMKYLSDMGYVHRDLAARNILVNAQLIC 783


>UniRef50_Q9V4E5 Eph receptor tyrosine kinase, isoform C n=25 Tax=Diptera
           RepID=Q9V4E5_DROME
          Length = 1096

 Score =  194 bits (495), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 50/170 (29%), Positives = 85/170 (50%), Gaps = 4/170 (2%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           S  D        QA+     E+    + +   +G G FG+V +G+L KI     Q + VA
Sbjct: 715 SYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRL-KIPPNFVQDIDVA 773

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           +KT K  S +++   + + EA +M   DH NV+   GV   + P+ +I E  + G+LD+ 
Sbjct: 774 IKTLKPGS-SEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTF 832

Query: 215 LGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L      F  ++   ++   A+G++Y+ + N +HRD+AARN L     + 
Sbjct: 833 LRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLIC 882


>UniRef50_C4XV88 Venus kinase receptor (Fragment) n=3 Tax=Coelomata RepID=C4XV88_STRPU
          Length = 1566

 Score =  193 bits (492), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 55/168 (32%), Positives = 88/168 (52%), Gaps = 18/168 (10%)

Query: 109  VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
            +   +WE+  E+V L +KLGEGAFG V+ G+ L     +++   VAVKT KL +  +E++
Sbjct: 1008 ITLDEWEMPRENVVLNRKLGEGAFGTVYGGEALL---DDNKWAAVAVKTLKLGASVEEKL 1064

Query: 169  KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA-LGKLHFP------ 221
             + + EA +M+  +H N+V   GV    EP+Y +ME    G L +  LG+ H        
Sbjct: 1065 -DFLSEAEVMKRFNHKNIVNLLGVCTRGEPMYAVMEFMLYGDLKTFLLGRRHLVGEGVYE 1123

Query: 222  -------MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                     +   ++   A+GL+Y+   N +HRD+A RNCL      +
Sbjct: 1124 RNQHVMCPDQLTSMVSDIASGLSYLASINYVHRDLACRNCLVDASYTV 1171


>UniRef50_Q93105 Insulin-like receptor beta chain n=1 Tax=Aedes aegypti
            RepID=INSR_AEDAE
          Length = 1393

 Score =  193 bits (492), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 64/257 (24%), Positives = 109/257 (42%), Gaps = 30/257 (11%)

Query: 32   LLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKV-------------YVDKIGFP 78
            LL   EP     R    ++ G+   SA  +V+   D  +             ++  +GF 
Sbjct: 925  LLTKLEPGNYSIRVMATTIAGDGAPSAARYVLIAKDDSMGTTLIWLGTLIVIFLCSVGFV 984

Query: 79   TIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKG 138
                    Y+S +     +     A ++  V    WE+    +   ++LG+G+FG V+KG
Sbjct: 985  AFYWYKYRYMSKQIRMYPEVNPDYAGVQYKV--DDWEVERNHIIQLEELGQGSFGMVYKG 1042

Query: 139  KLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEP 198
             L + L         A+KT   ES T  +    + EA +M+  +  +VV+  GV +  +P
Sbjct: 1043 ILTQ-LRGEKCNQPCAIKTVN-ESATAREKDSFLLEASVMKQFNTHHVVRLLGVVSQGDP 1100

Query: 199  LYVIMELADGGALDSALGKLH-------------FPMIKKYELIYQAANGLAYIHEKNLM 245
              VIMEL   G L S L +                 + +  ++  + A+G+AY+  K  +
Sbjct: 1101 TLVIMELMANGDLKSYLRRHRPDYENGEDPSPQPPTLRQIIQMAIEIADGMAYLSAKKFV 1160

Query: 246  HRDVAARNCLYGGGQVL 262
            HRD+AARNC+      +
Sbjct: 1161 HRDLAARNCMVADDMTV 1177


>UniRef50_Q4SFJ9 Chromosome 7 SCAF14601, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SFJ9_TETNG
          Length = 761

 Score =  193 bits (492), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 50/167 (29%), Positives = 81/167 (48%), Gaps = 6/167 (3%)

Query: 98  DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT 157
           D        +AV     E+    V++ + +G G FGEV +G+L        +   VA+KT
Sbjct: 386 DPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVCRGRLK---IPGKKENYVAIKT 442

Query: 158 AKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG- 216
            K    T +Q ++ + EA +M    H N++   GV   + P+ ++ E  + GALDS L  
Sbjct: 443 LK-GGYTDKQRRDFLSEASIMGQFQHPNIIHLEGVITASCPVMILTEFMENGALDSFLRL 501

Query: 217 -KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               F  I+   ++   A+G+ Y+ E + +HRD+AARN L     V 
Sbjct: 502 NDSQFTPIQLVGMLRGIASGMKYLSEMSYVHRDLAARNILINSNLVC 548


>UniRef50_C5H7R9 Venus kinase receptor (Fragment) n=2 Tax=Tribolium castaneum
            RepID=C5H7R9_TRICA
          Length = 1293

 Score =  193 bits (491), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 56/164 (34%), Positives = 83/164 (50%), Gaps = 17/164 (10%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             KWE+    V + +KLGEGAFG V+ G+       +   V VAVKT K+ S T+E++ + 
Sbjct: 892  DKWEIPRNSVVINRKLGEGAFGTVYGGEA---NFPDKGWVAVAVKTLKVGSSTEEKL-DF 947

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL-------------GKL 218
            + EA +M+  DH N++K  GV    EP+Y IME    G L + L                
Sbjct: 948  LSEAEVMKRFDHKNIIKLLGVCTKEEPIYTIMEFMLYGDLKTFLLARRHLVNDKTIEESD 1007

Query: 219  HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                 K   +    A GL+Y+ +   +HRDVA+RNCL    +++
Sbjct: 1008 EISSKKLTMMALDVARGLSYLAQLKYVHRDVASRNCLINAQRIV 1051


>UniRef50_UPI00019252ED PREDICTED: similar to predicted protein n=1 Tax=Hydra
           magnipapillata RepID=UPI00019252ED
          Length = 686

 Score =  193 bits (491), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 49/165 (29%), Positives = 79/165 (47%), Gaps = 15/165 (9%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+  + + +T+ LGEGAFG V K   + +         VAVK  K ++ T+ ++ ++
Sbjct: 355 PEWEVDRDCLHITETLGEGAFGVVVKADAVGLKKCEENHTTVAVKMLKADA-TENELLDL 413

Query: 172 MREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI------- 223
           + E   M+ +  HIN++ F G    ++P+YVI+E A  G L   L     PM        
Sbjct: 414 LSEMETMKQIGRHINIINFLGCCTQSDPVYVIVEYAPNGNLRQFLRSKRPPMSDNGYRSD 473

Query: 224 ------KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                        Q A G+ Y+  K  +HRD+AARN L     ++
Sbjct: 474 PLLSVKDIVSFALQIAKGMEYLASKKCIHRDLAARNILVTEDYIM 518


>UniRef50_Q25410 Putative molluscan insulin-related peptide(s) receptor beta chain n=8
            Tax=Coelomata RepID=MIPR_LYMST
          Length = 1607

 Score =  193 bits (491), Expect = 6e-48,   Method: Composition-based stats.
 Identities = 49/161 (30%), Positives = 86/161 (53%), Gaps = 11/161 (6%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             +WE+  + ++L K+LG+G+FG V++G    I D  ++ + VAVKT   +  +    +E 
Sbjct: 1028 DEWEVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVN-DRASFSDRREF 1086

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP---------- 221
            ++EA  M+     +VVK  GV +  +P  VIMEL   G L + L                
Sbjct: 1087 LKEATTMKEFHCHHVVKLLGVVSTGQPALVIMELMALGDLKNYLRGHRPDEDHPGVMPPH 1146

Query: 222  MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            ++   ++  + A+G+AY+ +K  +HRD+AARNC+    + +
Sbjct: 1147 LLDILQMAGEIADGMAYLADKKFVHRDLAARNCMVSEERTV 1187


>UniRef50_Q98TD0 Ephrin receptor n=6 Tax=Amniota RepID=Q98TD0_CHICK
          Length = 969

 Score =  193 bits (490), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 50/160 (31%), Positives = 79/160 (49%), Gaps = 6/160 (3%)

Query: 105 LKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMT 164
             + V     EL    V +   +GEG FGEV++G L        + ++VA+KT K  + +
Sbjct: 600 PSRGVLEFIKELDVSCVTMENVIGEGEFGEVYRGSLRL---PGKERIVVAIKTLK-STYS 655

Query: 165 KEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPM 222
             Q    +REA +M   +H N+V   GV     P+ +I E  + GALD+ L +    F  
Sbjct: 656 DSQWWNFLREATIMGQFNHPNIVHLEGVVTKRRPMMIITEYMENGALDTFLRENEEKFSP 715

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           ++   ++   A+G+ Y+ E N +HRD+AARN L       
Sbjct: 716 VQLVNMLQGIASGMTYLSEHNYVHRDLAARNILVTRSLQC 755


>UniRef50_B7QM19 Tyrosine-protein kinase receptor n=2 Tax=Ixodes scapularis
            RepID=B7QM19_IXOSC
          Length = 1458

 Score =  192 bits (489), Expect = 9e-48,   Method: Composition-based stats.
 Identities = 54/169 (31%), Positives = 86/169 (50%), Gaps = 18/169 (10%)

Query: 110  ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
            E  +WE+  E + L K LG+G+FG V++G L+  L  +      AVKT    +  +E+I 
Sbjct: 1038 EPDEWEVPRESINLVKALGQGSFGMVYEG-LIYNLKPDKPETKCAVKTVNESASMRERI- 1095

Query: 170  EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP-------- 221
            E ++EA +M+     +VVK  GV +  +P+YVIMEL   G L S L     P        
Sbjct: 1096 EFLQEAAVMKAFSCQHVVKLLGVVSKDQPVYVIMELMSNGDLKSYLRSHRPPTEGEEDDS 1155

Query: 222  --------MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                    + +  ++  + A+G+AY+     +HRD+AARNC+      +
Sbjct: 1156 KPRGQPPSLKQILQMAAEIADGMAYLTASKFVHRDLAARNCMVAEDLTV 1204


>UniRef50_C4XV92 Venus kinase receptor (Fragment) n=6 Tax=Drosophila
           RepID=C4XV92_DROMO
          Length = 1107

 Score =  192 bits (488), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 54/163 (33%), Positives = 84/163 (51%), Gaps = 16/163 (9%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            KWE+  ++V + ++LGEGAFG V+ G+     D   +   VAVKT K    T++++ + 
Sbjct: 719 DKWEVQKDNVVINRRLGEGAFGTVYGGEARLDSD---EWTAVAVKTLKAGQSTEDRL-DF 774

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL------------GKLH 219
           + EA  M+  +H N++K  GV   TEP+Y IME    G L + L             +  
Sbjct: 775 LAEAEAMKKFNHKNIIKLLGVCLQTEPIYTIMEFMLYGDLKTYLLARRNMVNEKLTDESD 834

Query: 220 FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               +        A+GLAY+ E+  +HRD+A RNCL    +V+
Sbjct: 835 ISSKRLTMYAMDVASGLAYLAEQKYVHRDIACRNCLVNSQRVV 877


>UniRef50_Q05397 Focal adhesion kinase 1 n=105 Tax=cellular organisms
           RepID=FAK1_HUMAN
          Length = 1052

 Score =  191 bits (486), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 60/212 (28%), Positives = 96/212 (45%), Gaps = 19/212 (8%)

Query: 61  FVVRESDHKVYVDKIGFPTIIELVN--------HYVSTKESFSTKDGTVKAVLKQAVERQ 112
           F++R         +   P+I +L N        H VS  E+    +   +         +
Sbjct: 358 FIIRPQKEG----ERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTR 413

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +E+  E +EL + +GEG FG+V +G     +   +  + VA+KT K    +    ++ +
Sbjct: 414 DYEIQRERIELGRCIGEGQFGDVHQGIY---MSPENPALAVAIKTCK-NCTSDSVREKFL 469

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIY 230
           +EA  MR  DH ++VK  GV     P+++IMEL   G L S L   K    +       Y
Sbjct: 470 QEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAY 528

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q +  LAY+  K  +HRD+AARN L      +
Sbjct: 529 QLSTALAYLESKRFVHRDIAARNVLVSSNDCV 560


>UniRef50_B2WR86 Fibroblast growth factor receptor A n=3 Tax=Nematostella vectensis
           RepID=B2WR86_NEMVE
          Length = 877

 Score =  191 bits (485), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 52/194 (26%), Positives = 86/194 (44%), Gaps = 21/194 (10%)

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
            S  +S S           +    + WE+    + + ++LGEGAFG V K + L + D  
Sbjct: 522 SSRLDSSSVITEESFLDFYELPIDEDWEIDRSQITIKEQLGEGAFGLVMKAEALGLTDMP 581

Query: 148 HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELA 206
           ++   VAVK  K ++ T+ ++ +++ E   M+N+  H N++   G      PLYV++E A
Sbjct: 582 YRHT-VAVKMLKADA-TENELADLLSEMDTMKNIGSHKNIINLIGACTQNGPLYVVVEFA 639

Query: 207 DGGALDSALGKLHFP------------------MIKKYELIYQAANGLAYIHEKNLMHRD 248
             G L   L +                      +       +Q A G+ Y+  K  +HRD
Sbjct: 640 PHGNLRQFLRERRPSDYHRSRSDSSTHSQPSLIVRDFISFAFQIARGMEYLSFKKCIHRD 699

Query: 249 VAARNCLYGGGQVL 262
           +AARN L G   V+
Sbjct: 700 LAARNILVGEDYVM 713


>UniRef50_UPI0000DB6DD4 PREDICTED: similar to Insulin-like growth factor 1 receptor
           precursor (Insulin-like growth factor I receptor) (IGF-I
           receptor) n=1 Tax=Apis mellifera RepID=UPI0000DB6DD4
          Length = 855

 Score =  190 bits (484), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 24/236 (10%)

Query: 49  SVVGEKK-TSANHFVVRESDHKVYVDKIG---FPTII---ELVNHYVSTKESFSTKDGTV 101
           S+ G    T   +F + E +       +    F  ++    LV  Y   ++         
Sbjct: 245 SLAGNGAYTHVKYFYIEERNTMNTFWIVFWLLFCAVLAALSLVAFYACKRKFLRNVPNVT 304

Query: 102 ------KAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAV 155
                    +       +WE+  E +E+ + LG G FG V++G    I+    + V  AV
Sbjct: 305 LIATVNPEYVSTPYVLDEWEVPREKIEMLRSLGTGTFGMVYEGIAKDIVKGKSE-VRCAV 363

Query: 156 KTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL 215
           KT   ++  +E+I E + EA +M+  D  +VVK  GV    +P  VIMEL   G L   L
Sbjct: 364 KTVNKDATDRERI-EFLNEASVMKGFDAHHVVKLLGVVTRGQPTLVIMELMVNGDLKRYL 422

Query: 216 GKLH---------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                          + +  ++  + A+G+AY+  K  +HRD+AARNC+      +
Sbjct: 423 RSHRPCENMSNAPPKLDRILQMAIEIADGMAYLSTKKFVHRDLAARNCMVAEDLTV 478


>UniRef50_B7Q0S4 Tyrosine-protein kinase receptor n=1 Tax=Ixodes scapularis
           RepID=B7Q0S4_IXOSC
          Length = 829

 Score =  190 bits (484), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 53/166 (31%), Positives = 79/166 (47%), Gaps = 19/166 (11%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+    V   ++LGEGAFG+V++G+LL +      P+ VA+KT K  +  K Q ++  RE
Sbjct: 474 EVPSPQVRFLQELGEGAFGKVYRGELLPVKRDCSLPIQVAIKTLKENAAMKTQ-QDFQRE 532

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---------FPMIKK 225
           A LM +L H N+V   GV    EPL ++ E    G L   L +             +   
Sbjct: 533 AELMSDLQHPNIVCLLGVCTKEEPLCMLFEYMPHGDLHEFLVQHSPRCEGTTQVLDLADF 592

Query: 226 YELIYQ---------AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             +  Q          A G+ Y+   + +HRD+AARNCL G    +
Sbjct: 593 LHISRQASQSINAFFVAAGMEYLSAHHYVHRDLAARNCLVGESLTV 638


>UniRef50_UPI00017923B4 PREDICTED: similar to insulin receptor n=1 Tax=Acyrthosiphon pisum
            RepID=UPI00017923B4
          Length = 1475

 Score =  190 bits (483), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 51/191 (26%), Positives = 89/191 (46%), Gaps = 15/191 (7%)

Query: 83   LVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLK 142
            L  +Y +   S           +    +  +WE+  +DVE+ + LG G+FG V++G   K
Sbjct: 1051 LHRYYKNKLASTRLFVTCNPDYVSCEYQTDEWEIPRDDVEVLEPLGRGSFGMVYRGNWKK 1110

Query: 143  ILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVI 202
                 ++ V  A+KT   E+       + + EA +M+     +VV+ +GV +  +P +V+
Sbjct: 1111 ---KENEIVPCAIKTV-TENNNMMVRHDFLSEANVMKEFCSAHVVRLYGVVSQGQPAFVL 1166

Query: 203  MELADGGALDSALGKLHFPMI-----------KKYELIYQAANGLAYIHEKNLMHRDVAA 251
            MEL   G L S L K    M                +  + A+G++Y+  K  +HRD+AA
Sbjct: 1167 MELMPQGDLKSYLLKHRPEMTTDPSLKPPTLRDNLRMAIEIADGMSYLSFKKYVHRDLAA 1226

Query: 252  RNCLYGGGQVL 262
            RNC+     ++
Sbjct: 1227 RNCMVSDNNIV 1237


>UniRef50_Q7Q0F6 Tyrosine-protein kinase receptor n=1 Tax=Anopheles gambiae
            RepID=Q7Q0F6_ANOGA
          Length = 1318

 Score =  190 bits (483), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 50/164 (30%), Positives = 85/164 (51%), Gaps = 16/164 (9%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             +WE+  E +   ++LG+G+FG V+KG + K+   N   V  A+KT   E+ T+ +    
Sbjct: 984  DEWEVPREHIIQLEELGQGSFGMVYKGIMTKL--GNDVNVPCAIKTV-TENATERERDSF 1040

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH------------ 219
            + EA +M+     +VV+ +GV +  +P  VIMEL   G L S L +              
Sbjct: 1041 LIEATIMKEFHTHHVVRLYGVVSVGQPTLVIMELMANGDLKSYLRRHRPDYENGEESSPQ 1100

Query: 220  -FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               + + Y++  + A+G+AY+  K  +HRD+AARNC+      +
Sbjct: 1101 PPTLKQIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVAEDLTV 1144


>UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rerio
           RepID=Q910A2_DANRE
          Length = 586

 Score =  190 bits (483), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 70/302 (23%), Positives = 117/302 (38%), Gaps = 59/302 (19%)

Query: 7   LHQKYYHGLLPREDIQEMLNK----PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
               ++HG + RED +  L       GQ   +T      ++    L ++   +    H+ 
Sbjct: 159 EKMPWFHGKIDREDSELRLLNTSRVNGQISNQTKRKQWQKRVPNALCLLHNNQ--VMHYR 216

Query: 63  V-RESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ------------- 107
           + ++   K+ + D   F T+ +LV HY    +                            
Sbjct: 217 IDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHSEGSAENPYKIT 276

Query: 108 ------------------AVERQKWE-------------LYHEDVELTK-KLGEGAFGEV 135
                              ++ Q +E             +   D+ L   +LG G FG V
Sbjct: 277 SNGKDNYSKQGNFLDSAMPMDTQVYESPYADPDELRSTKVNRSDLTLEDGELGSGNFGTV 336

Query: 136 WKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAG 195
            +G             +VAVK  K +        E++REA +M+ LD+  +V+  G+   
Sbjct: 337 LRGVYQ----MKKTQKVVAVKILKNDDDNAAVKDEMLREANVMQQLDNPYIVRMIGIC-E 391

Query: 196 TEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNC 254
            E L ++MELA+ G L   L K  H  +    EL++Q + G+ Y+ E N +HRD+AARN 
Sbjct: 392 AENLMLVMELAELGPLHKFLQKNKHITVKNLTELVHQVSMGMKYLEEHNFVHRDLAARNV 451

Query: 255 LY 256
           L 
Sbjct: 452 LL 453



 Score = 58.2 bits (140), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 21/119 (17%), Positives = 45/119 (37%), Gaps = 14/119 (11%)

Query: 10  KYYHGLLPREDIQEMLNK----PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
            Y+ G + RE+ +  L +     G +LLR S    G    + LS+   ++    H+ +  
Sbjct: 9   PYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLG---GYALSLSYGRQ--FYHYTIER 63

Query: 66  --SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
             +D           T I+++N++    +        +K    +    +      ED++
Sbjct: 64  ELNDTYAIAGGKSHRTPIDVINYHSQESDGLIC---LLKKPFHRPRGTEPKVGPFEDLK 119


>UniRef50_Q17JW1 Tyrosine protein kinase n=2 Tax=Culicini RepID=Q17JW1_AEDAE
          Length = 722

 Score =  189 bits (482), Expect = 6e-47,   Method: Composition-based stats.
 Identities = 53/163 (32%), Positives = 84/163 (51%), Gaps = 16/163 (9%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            KWE+  + V + ++LGEGAFG V+ G+       +     VAVKT K+ S T++++ + 
Sbjct: 284 DKWEVPKDRVVINRRLGEGAFGTVYGGEA---QIGDEGWTAVAVKTLKIGSTTEDKV-DF 339

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA-LGKLHF---------- 220
           + EA  M+  DH N+VK  GV   TEP+Y IME    G L +  L + H           
Sbjct: 340 LSEAEAMKRFDHNNIVKLLGVCLQTEPVYTIMEFMLYGDLKTYLLARRHLVNSKQSEDSD 399

Query: 221 -PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               +   +    +  L+Y+ E+  +HRD+A RNC+    +V+
Sbjct: 400 ISPKRLTMMALDVSRALSYLAEQKYVHRDLACRNCMVNAQRVV 442


>UniRef50_UPI000186E0DC Insulin receptor precursor, putative n=2 Tax=Pediculus humanus
            corporis RepID=UPI000186E0DC
          Length = 1289

 Score =  189 bits (481), Expect = 7e-47,   Method: Composition-based stats.
 Identities = 49/162 (30%), Positives = 85/162 (52%), Gaps = 13/162 (8%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             +WE+  E++EL ++LG+G+FG V++G    I+      V  AVKT    S  ++++ E 
Sbjct: 928  DEWEVPRENIELIRELGQGSFGMVYEGIARDIVQG-EPEVRCAVKTVNEVSTDRDRM-EF 985

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG-----------KLHF 220
            + EA +M+  +  +VV+  GV +  +P  V+MEL   G L + L            K   
Sbjct: 986  LNEASVMKAFNTHHVVQLLGVVSEGQPTLVVMELMVNGDLKTYLRSHRPEFCEDKKKQPP 1045

Query: 221  PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + +   +  + A+G+AY+  K  +HRD+AARNC+      +
Sbjct: 1046 TLRRIIRMAMEIADGMAYLAAKKFVHRDLAARNCMVAEDLTV 1087


>UniRef50_P00529 Tyrosine-protein kinase transforming protein ros n=12 Tax=root
           RepID=ROS_AVISU
          Length = 402

 Score =  189 bits (481), Expect = 7e-47,   Method: Composition-based stats.
 Identities = 56/153 (36%), Positives = 77/153 (50%), Gaps = 9/153 (5%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
              + + L K LG GAFGEV++G  L IL        VAVKT K  +  +E+  E ++EA
Sbjct: 93  FPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEK-SEFLKEA 151

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPM-----IKKYE 227
            LM   DH +++K  GV    EP Y+I+EL +GG L S L    K  F           +
Sbjct: 152 HLMSKFDHPHILKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLD 211

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
           +      G  Y+ +   +HRD+AARNCL    Q
Sbjct: 212 ICLDICKGCVYLEKMRFIHRDLAARNCLVSEKQ 244


>UniRef50_C5H7S1 Venus kinase receptor n=3 Tax=Culicidae RepID=C5H7S1_ANOGA
          Length = 1465

 Score =  189 bits (481), Expect = 8e-47,   Method: Composition-based stats.
 Identities = 51/163 (31%), Positives = 84/163 (51%), Gaps = 16/163 (9%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             KWE+  + V + ++LGEGAFG V+ G+       +     VAVKT K+ S T++++ + 
Sbjct: 945  DKWEIPKDRVVINRRLGEGAFGTVYGGEA---QIGDEGWTAVAVKTLKVGSTTEDKV-DF 1000

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA-LGKLHF---------- 220
            + EA  M+  DH N+V+  GV   +EP+Y +ME    G L +  L + H           
Sbjct: 1001 LSEAEAMKRFDHNNIVRLLGVCLQSEPVYTVMEFMLYGDLKTYLLARRHLVNSKQSEDSD 1060

Query: 221  -PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                +   +    +  L+Y+ E+  +HRDVA RNC+    +V+
Sbjct: 1061 ISNKRLTVMALDVSRALSYLAEQKYVHRDVACRNCMVNAQRVV 1103


>UniRef50_Q8IXC7 Isoform of FGFR2 n=10 Tax=Euteleostomi RepID=Q8IXC7_HUMAN
          Length = 709

 Score =  189 bits (480), Expect = 9e-47,   Method: Composition-based stats.
 Identities = 52/173 (30%), Positives = 78/173 (45%), Gaps = 20/173 (11%)

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKI-LDANHQPVLVAVKTAKLESMTKEQ 167
            E  KWE   + + L K LGEG FG+V   + + I  D   + V VAVK  K ++ T++ 
Sbjct: 357 PEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA-TEKD 415

Query: 168 IKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP----- 221
           + +++ E  +M+ +  H N++   G      PLYVI+E A  G L   L     P     
Sbjct: 416 LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 475

Query: 222 ------------MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                               YQ A G+ Y+  +  +HRD+AARN L     V+
Sbjct: 476 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 528


>UniRef50_P21802 Fibroblast growth factor receptor 2 n=316 Tax=Euteleostomi
           RepID=FGFR2_HUMAN
          Length = 821

 Score =  189 bits (480), Expect = 9e-47,   Method: Composition-based stats.
 Identities = 52/173 (30%), Positives = 78/173 (45%), Gaps = 20/173 (11%)

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKI-LDANHQPVLVAVKTAKLESMTKEQ 167
            E  KWE   + + L K LGEG FG+V   + + I  D   + V VAVK  K ++ T++ 
Sbjct: 469 PEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA-TEKD 527

Query: 168 IKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP----- 221
           + +++ E  +M+ +  H N++   G      PLYVI+E A  G L   L     P     
Sbjct: 528 LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 587

Query: 222 ------------MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                               YQ A G+ Y+  +  +HRD+AARN L     V+
Sbjct: 588 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 640


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score =  189 bits (480), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 75/333 (22%), Positives = 128/333 (38%), Gaps = 85/333 (25%)

Query: 5   DLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           +L    ++ G + RE  +E+L   + G FL+R S    G+    V+S    KK   ++ V
Sbjct: 26  ELDLANWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVE-HYRV 84

Query: 63  VRESDHKVYVDKIGF-PTIIELVNHYVSTKESFST----------KDGTVKAVLKQAVER 111
           +  +D++V VD+  F P +IEL+ HY    +   T          +     A+ K++ ++
Sbjct: 85  ISTNDNRVTVDEDAFFPNLIELIKHYERDADGLCTMLKKPLKKKTEMVLQSAIFKESFQK 144

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMT------- 164
           + W +  EDVE  + +G+G FG+V+KG   K          VA+K  + +S T       
Sbjct: 145 EGWAVPIEDVEFKELIGKGEFGDVYKGVWAKK--------TVAIKKLRDDSKTAQSLLAE 196

Query: 165 ------KEQIKEIMREARLMRNLDHINVVK--------------------FFGVAAG--- 195
                  + + + M   R +        +K                    F GV      
Sbjct: 197 ASMRYDDDMVAKFMHMNRFLAYFYTPAWIKPSGGADASMNNLQFVYDMIDFRGVIKDIAD 256

Query: 196 -------TEPLYV--------------IMELA---DGGALDSALG---KLHFPMIKKYEL 228
                      Y+              +M  A   + G L   L    +    + ++   
Sbjct: 257 FVINKLHNHHWYLSEKVVLFALFGKHPLMTHALKKEMGVLVEYLRTRGRAVITLEEQKGF 316

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
                NG+ Y+ EKN++HRD+AARN L      
Sbjct: 317 AIDVCNGMRYLEEKNIIHRDLAARNVLLSDELC 349


>UniRef50_B4JPQ9 GH13351 n=3 Tax=Drosophila RepID=B4JPQ9_DROGR
          Length = 1165

 Score =  189 bits (480), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 52/163 (31%), Positives = 81/163 (49%), Gaps = 16/163 (9%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            KWE+  E+V + ++LGEGAFG V+ G+     D       VAVKT K    T++++ + 
Sbjct: 772 DKWEVPRENVVVNRRLGEGAFGTVYGGEAKFNSDD---WTAVAVKTLKSGGSTEDRL-DF 827

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL------------GKLH 219
           + EA  M+  +H N++K  GV    EP+Y IM+    G L + L             +  
Sbjct: 828 LAEAEAMKKFNHKNIIKLLGVCLQKEPIYTIMQFMLYGDLKTYLLARRNMVNEKITDESD 887

Query: 220 FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               +        A GLAY+ E+  +HRD+A RNCL    +++
Sbjct: 888 ISSKRLTMYAMDVARGLAYLAEQKYVHRDIACRNCLVDSQRMV 930


>UniRef50_Q16620 BDNF/NT-3 growth factors receptor n=90 Tax=Euteleostomi
           RepID=NTRK2_HUMAN
          Length = 822

 Score =  189 bits (480), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 48/161 (29%), Positives = 78/161 (48%), Gaps = 17/161 (10%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +   ++ L ++LGEGAFG+V+  +   +       +LVAVKT K    +    K+  REA
Sbjct: 533 IKRHNIVLKRELGEGAFGKVFLAECYNLC-PEQDKILVAVKTLK--DASDNARKDFHREA 589

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--------------HFP 221
            L+ NL H ++VKF+GV    +PL ++ E    G L+  L                    
Sbjct: 590 ELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELT 649

Query: 222 MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             +   +  Q A G+ Y+  ++ +HRD+A RNCL G   ++
Sbjct: 650 QSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV 690


>UniRef50_Q2EKC1 Fibroblast growth factor receptor n=3 Tax=Eumetazoa
           RepID=Q2EKC1_BRABE
          Length = 856

 Score =  188 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 49/168 (29%), Positives = 79/168 (47%), Gaps = 19/168 (11%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             WE   + + L K LGEG FG+V     + I++       VAVK  K ++ T+ ++ ++
Sbjct: 506 PDWEFPRDRLHLGKPLGEGCFGQVVMADAVGIIE-KETVTTVAVKMLKEDA-TERELADL 563

Query: 172 MREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYEL-- 228
           + E   M+ +  H N++   G      PL+VI+E A+ G L   L     P +  Y++  
Sbjct: 564 VSEMETMKRIGKHKNIINLLGCCTQDGPLFVIVEYAEHGNLRDFLRARRPPSMDYYKMAV 623

Query: 229 --------------IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                          YQ   G+ ++H K  +HRD+AARN L   G V+
Sbjct: 624 ECDKPLTHKDLVSFAYQIGRGMEFLHSKKCIHRDLAARNVLVAEGNVM 671


>UniRef50_UPI0001925F5B PREDICTED: similar to ephrin receptor EphA5 n=2 Tax=Hydra
           magnipapillata RepID=UPI0001925F5B
          Length = 747

 Score =  188 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 45/167 (26%), Positives = 82/167 (49%), Gaps = 7/167 (4%)

Query: 98  DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT 157
           D     ++  AV +  +E+   ++   + +G G F +V KG L+K      +   VA+K 
Sbjct: 320 DPKTFLLVSDAVSQFAYEIERSEIVFGELIGSGEFADVHKGVLMK----EGKKEPVAIKV 375

Query: 158 AKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK 217
            K    ++   ++ + EA ++    + NV+   GV    EP  +++E  + GALDS L +
Sbjct: 376 LK-NGASESDREDFLSEAAILGQFSNPNVIFLEGVVLKDEPNLIVLEYMEYGALDSYLKE 434

Query: 218 --LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + F + +  E+    A+G+ Y+ E   +HRD+AARN L    +  
Sbjct: 435 HDMQFTIEQLLEMARGVASGMKYLSEMGFVHRDLAARNILVNEKKTC 481


>UniRef50_Q9U5A8 Tyrosine-protein kinase receptor n=4 Tax=Coelomata RepID=Q9U5A8_BOMMO
          Length = 1472

 Score =  188 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 52/194 (26%), Positives = 94/194 (48%), Gaps = 20/194 (10%)

Query: 83   LVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLK 142
            L++H  ++K   S     V  V        +WE+  + +   ++LG+G+FG V++G   +
Sbjct: 1048 LMSHAEASKLFASVNPEYVPTVYVP----DEWEVTRDSIHFIRELGQGSFGMVYEGIAKE 1103

Query: 143  ILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVI 202
            I+         A+KT    +  +E+I E + EA +M+  D  +VV+  GV +  +P  V+
Sbjct: 1104 IVKG-KPETRCAIKTVNEHATDRERI-EFLNEASVMKAFDTFHVVRLLGVVSRGQPTLVV 1161

Query: 203  MELADGGALDSALGKLH--------------FPMIKKYELIYQAANGLAYIHEKNLMHRD 248
            MEL + G L + L  +                 +    ++  + A+G+AY+  K  +HRD
Sbjct: 1162 MELMERGDLKTYLRSMRPDAEGSLPSSPPVPPTLQNILQMAIEIADGMAYLSAKKFVHRD 1221

Query: 249  VAARNCLYGGGQVL 262
            +AARNC+  G   +
Sbjct: 1222 LAARNCMVAGDLTV 1235


>UniRef50_C5H7S0 Venus kinase receptor (Fragment) n=2 Tax=Apis mellifera
            RepID=C5H7S0_APIME
          Length = 1238

 Score =  188 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 51/179 (28%), Positives = 84/179 (46%), Gaps = 17/179 (9%)

Query: 97   KDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVK 156
            K   +      + +  KWE+    V + +KLGEGAFG V+ G+           + VAVK
Sbjct: 853  KSMGISYACDDSSDLDKWEIPRHRVVINRKLGEGAFGTVYGGEA---FFPEKGWLAVAVK 909

Query: 157  TAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL- 215
            T K+ S T+E++ + + E  +M+  +H N++K  GV   +EP+  +ME    G L + L 
Sbjct: 910  TLKIGSSTEEKL-DFLSEVEVMKQFEHKNIIKLLGVCIKSEPVLTVMEFMLYGDLKTYLL 968

Query: 216  ------------GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                                K   +    A  L+Y+ +   +HRD+A+RNCL    +V+
Sbjct: 969  ARRHLVNDNSYEDSDEISNKKLTAMALDVARALSYLAQSKYVHRDIASRNCLVNAQRVV 1027


>UniRef50_C4QEV8 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4QEV8_SCHMA
          Length = 643

 Score =  188 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 53/205 (25%), Positives = 100/205 (48%), Gaps = 11/205 (5%)

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-WELYHEDV 121
           + +   +   ++       +L N +   ++    K+     +    +++ + +E   +++
Sbjct: 294 INKIKERYTTNRYVSSESQQLYNRFTHEEDLQRLKELDKLFLSNYQLKKDEDYEFSRKNL 353

Query: 122 ELTKKLGEGAFGEVWKGKLLKILD--ANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           +LT +LG GAFG V++G    + +    ++ + VAVKT K +  T+  + E + E  +M+
Sbjct: 354 QLTCRLGSGAFGIVYRGVAENLPNCINTNEKIDVAVKTLK-DDFTEGDVSEFLMEVNIMK 412

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPM-------IKKYELIYQA 232
            L H ++++F+GV        +IME A  G L   L +            +K     YQ 
Sbjct: 413 QLRHKHIIEFYGVCTENGSPLLIMEYAPYGNLKEYLRRHRKIWLNCDNLSLKLLNFGYQV 472

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYG 257
           A+G+ Y+  K L+HRD+AARN L G
Sbjct: 473 ADGMKYLESKCLIHRDLAARNILVG 497


>UniRef50_UPI0001792C07 PREDICTED: similar to tyrosine-protein kinase n=1 Tax=Acyrthosiphon
            pisum RepID=UPI0001792C07
          Length = 1518

 Score =  188 bits (478), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 54/170 (31%), Positives = 93/170 (54%), Gaps = 7/170 (4%)

Query: 96   TKDGTVKAVLKQAVERQKW-ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
               G   AVL Q  ++ +   +  E + LTK+LG GAFGEV++GK+  ++    +   VA
Sbjct: 1125 VNVGYQGAVLFQKKKKNELPSIKREQITLTKRLGSGAFGEVFEGKIKDVVRGECE-TRVA 1183

Query: 155  VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
            +K+ K E  +  +++E ++EA+LM N +H ++++  GV    +P ++IMEL + G L S 
Sbjct: 1184 IKSLK-EGASHCEVEEFLKEAKLMNNFNHKHILQLIGVCLDNDPNFIIMELMEEGDLLSY 1242

Query: 215  LGKLHFPMIKKY----ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
            L K     +       ++    A G +Y+ + + +HRD+A RNCL     
Sbjct: 1243 LRKNRQTNVLNLSDYGQMCIDVAEGCSYLEQMHFIHRDLACRNCLVSSSD 1292


>UniRef50_Q4S6E0 Chromosome 10 SCAF14728, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4S6E0_TETNG
          Length = 713

 Score =  188 bits (477), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 52/190 (27%), Positives = 82/190 (43%), Gaps = 22/190 (11%)

Query: 94  FSTKDGTVKAVLKQA--VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN-HQP 150
            S+ DG + A + +       KWE     + L K LGEG FG+V     + I     ++P
Sbjct: 304 LSSSDGPMLANVSELELPPDPKWEFPRTRLTLGKPLGEGCFGQVVMADAVGIDKEKPNKP 363

Query: 151 VLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGG 209
           + VAVK  K ++  K+ + +++ E  +M+ +  H N++   G      PLYV++E A  G
Sbjct: 364 LTVAVKMLKDDATDKD-LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKG 422

Query: 210 ALDSALG-----------------KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAAR 252
            L   L                               YQ A G+ Y+  +  +HRD+AAR
Sbjct: 423 NLREYLRARRPPGMDYSFDTCKIPDEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAAR 482

Query: 253 NCLYGGGQVL 262
           N L     V+
Sbjct: 483 NVLVTDDNVM 492


>UniRef50_P08922 Proto-oncogene tyrosine-protein kinase ROS n=24 Tax=Coelomata
            RepID=ROS_HUMAN
          Length = 2347

 Score =  188 bits (477), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 55/150 (36%), Positives = 78/150 (52%), Gaps = 9/150 (6%)

Query: 116  LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
               E + L   LG GAFGEV++G  + IL      + VAVKT K  S  +E+I E ++EA
Sbjct: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKI-EFLKEA 1998

Query: 176  RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPM--------IKKYE 227
             LM   +H N++K  GV    EP Y+I+EL +GG L + L K             +   +
Sbjct: 1999 HLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVD 2058

Query: 228  LIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
            L    + G  Y+   + +HRD+AARNCL  
Sbjct: 2059 LCVDISKGCVYLERMHFIHRDLAARNCLVS 2088


>UniRef50_UPI000155484B PREDICTED: similar to type 1 IGF receptor n=1 Tax=Ornithorhynchus
           anatinus RepID=UPI000155484B
          Length = 1055

 Score =  187 bits (476), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 48/163 (29%), Positives = 85/163 (52%), Gaps = 14/163 (8%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+  E + + ++LG+G+FG V++G    ++  +     VA+KT    +  +E+I E 
Sbjct: 682 DEWEVPREKITMCRELGQGSFGMVYEGIAKGVVK-DEPETRVAIKTVNESASMRERI-EF 739

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH------------ 219
           + EA +M+  +  +VV+  GV +  +P  VIMEL   G L S L  L             
Sbjct: 740 LNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTEQNNPGQAP 799

Query: 220 FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + K  ++  + A+G+AY++    +HRD+AARNC+      +
Sbjct: 800 PTLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV 842


>UniRef50_Q7KJ08 Alk n=7 Tax=melanogaster group RepID=Q7KJ08_DROME
          Length = 1701

 Score =  187 bits (476), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 51/159 (32%), Positives = 81/159 (50%), Gaps = 13/159 (8%)

Query: 115  ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
            ++  + ++L   LG+GAFGEV+   L +  D +   + VAVKT + E   +E+ ++ ++E
Sbjct: 1187 QVARDSLQLVNALGKGAFGEVYMA-LYRHRDGDAVEMGVAVKTLR-EDPKREKEEDFLKE 1244

Query: 175  ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIKKY 226
            A +M   +H N+V   GV    +P Y+++EL  GG L   L +            M    
Sbjct: 1245 AAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLL 1304

Query: 227  ELIYQAANGLAYIHEKNLMHRDVAARNCLY---GGGQVL 262
                  A G  Y+  K  +HRD+AARNCL    G G+V+
Sbjct: 1305 FCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVV 1343


>UniRef50_UPI0001926939 PREDICTED: similar to eph receptor A7 n=4 Tax=Hydra magnipapillata
           RepID=UPI0001926939
          Length = 838

 Score =  187 bits (476), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 60/216 (27%), Positives = 96/216 (44%), Gaps = 20/216 (9%)

Query: 46  FVLSVVGEKKTSANHFV-VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAV 104
           F+L +   KK    +F  VR  D  V +    F +            +     D T    
Sbjct: 403 FILGLYIWKKRHPMYFQAVRMEDGTVKLPSGPFKS------------QGKVYVDPTTYKD 450

Query: 105 LKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMT 164
           +  AVE   +EL  +D++    LG G F EV+KG LL+    + +P+ VA+K  K    +
Sbjct: 451 VDDAVEEFAYELERKDLKFGTLLGGGEFAEVYKGTLLR----DGKPIDVAIKILK-NGAS 505

Query: 165 KEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPM 222
           K    + + EA ++      NV+   GV    +P  +++E    GALD  L +    F  
Sbjct: 506 KHDRDDFLGEAAILGQFADQNVICLEGVILRDKPNLIVLEYMANGALDKFLQENDNQFTT 565

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           ++   +    A+G+ Y+ E   +HRD+AARN L   
Sbjct: 566 LQLLGMARGVASGMKYLSEMGFIHRDLAARNILVDE 601


>UniRef50_UPI000186EE87 tyrosine kinase receptor, putative n=4 Tax=Neoptera
           RepID=UPI000186EE87
          Length = 630

 Score =  187 bits (476), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 55/168 (32%), Positives = 83/168 (49%), Gaps = 17/168 (10%)

Query: 110 ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
              KWE     +++   LGEG FG+VW+ + L I D      +VAVKT K ES  +++ K
Sbjct: 316 PGDKWEFPRHHLKVFNILGEGCFGQVWRCEALNI-DGREGTTVVAVKTLK-ESAGEKERK 373

Query: 170 EIMREARLMRNLD-HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------- 219
           ++++E  +M++L+ H N+V+  G     +PL+VIME    G L S L             
Sbjct: 374 DLLQELEVMKSLEPHPNIVRLLGCCTKKDPLFVIMEFVSLGKLQSYLRNSRAERCYGNMH 433

Query: 220 -----FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                          YQ A G+ ++  K ++HRD+AARN L    QV 
Sbjct: 434 GESKTLTSRDLTSFAYQCARGMEFLSNKGIIHRDLAARNILVNNDQVC 481


>UniRef50_P06213 Insulin receptor subunit beta n=70 Tax=Euteleostomi RepID=INSR_HUMAN
          Length = 1382

 Score =  187 bits (475), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 50/162 (30%), Positives = 85/162 (52%), Gaps = 13/162 (8%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             +WE+  E + L ++LG+G+FG V++G    I+    +   VAVKT    +  +E+I E 
Sbjct: 1014 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAE-TRVAVKTVNESASLRERI-EF 1071

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-----------F 220
            + EA +M+     +VV+  GV +  +P  V+MEL   G L S L  L             
Sbjct: 1072 LNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPP 1131

Query: 221  PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + +  ++  + A+G+AY++ K  +HRD+AARNC+      +
Sbjct: 1132 TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTV 1173


>UniRef50_UPI000175802D PREDICTED: similar to leukocyte receptor tyrosine protein kinase
           n=1 Tax=Tribolium castaneum RepID=UPI000175802D
          Length = 1282

 Score =  187 bits (475), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 51/159 (32%), Positives = 79/159 (49%), Gaps = 13/159 (8%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           ++  E + L K LG+GAFGEV++G   +    +   + VAVKT   E  T +   + + E
Sbjct: 812 DIPREQLRLVKALGQGAFGEVYQGFYRQ-RPCDTVEMPVAVKTL-PEMSTSQAEMDFLME 869

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIKKY 226
           A +M   +H N+V F GV     P ++++EL  GG L + L +            M    
Sbjct: 870 ALIMSKFNHPNIVHFIGVCFDKHPRFIVLELLAGGDLKNFLRESRPKPERGSPLTMKDLV 929

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLY---GGGQVL 262
            +    A G  Y+ +   +HRD+AARNCL    G G+V+
Sbjct: 930 LIAVDVAKGCKYLEDNRFIHRDIAARNCLLTTKGPGRVV 968


>UniRef50_B7P3J2 Leukocyte tyrosine kinase receptor, putative n=1 Tax=Ixodes
           scapularis RepID=B7P3J2_IXOSC
          Length = 662

 Score =  187 bits (475), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 58/175 (33%), Positives = 84/175 (48%), Gaps = 28/175 (16%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQP----------------VLVAVKTA 158
           ++  E++ L K LG+GAFGEV++G LL                         V VAVKT 
Sbjct: 305 DIPRENLTLVKALGQGAFGEVYQGFLLPAAVPTSPTSPVSEGAPPLASAAADVPVAVKTL 364

Query: 159 KLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL 218
             E  + E  K+ + EA +M   +H N+V+F GV     P ++++EL  GG L S L + 
Sbjct: 365 -PELSSPESEKDFVTEACIMSKFNHPNIVRFIGVCFEKMPRFIVLELLAGGDLKSFLRES 423

Query: 219 H--------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLY---GGGQVL 262
                      M     L    A G  Y+ +K+ +HRD+AARNCL    G G+V+
Sbjct: 424 RPKPSIPPSLTMTDLLNLAIDVAKGCQYLEDKHFIHRDIAARNCLLTTKGPGRVV 478


>UniRef50_Q0P4R9 Discoidin domain receptor family, member 2 n=5 Tax=Euteleostomi
           RepID=Q0P4R9_XENTR
          Length = 879

 Score =  187 bits (475), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 22/169 (13%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDA--------NHQPVLVAVKTAKLESMTKE 166
           E     + L +KLGEG FGEV   +   + +         + QP +VAVK  + + +TK 
Sbjct: 579 EFPRNQLRLKEKLGEGQFGEVHLCEAEGLQEFLEMSPNEFSDQPNMVAVKMLRPD-VTKT 637

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHF------ 220
              + ++E +++  L H N+++  GV    +PL +I E  + G L+  L +         
Sbjct: 638 ARNDFLKEIKIISRLKHPNIIRLLGVCVRDDPLCMITEYMENGDLNQFLSQREIRSQFTK 697

Query: 221 -------PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                         +  Q A G+ Y+   N +HRD+A RNCL G    +
Sbjct: 698 ANNIPSVSRQNLLYMAAQIAAGMKYLASLNFVHRDLATRNCLVGNSYTI 746


>UniRef50_P08069 Insulin-like growth factor 1 receptor beta chain n=67
            Tax=Euteleostomi RepID=IGF1R_HUMAN
          Length = 1367

 Score =  187 bits (475), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 48/162 (29%), Positives = 86/162 (53%), Gaps = 13/162 (8%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             +WE+  E + ++++LG+G+FG V++G    ++  +     VA+KT    +  +E+I E 
Sbjct: 990  DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVK-DEPETRVAIKTVNEAASMRERI-EF 1047

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-----------F 220
            + EA +M+  +  +VV+  GV +  +P  VIMEL   G L S L  L             
Sbjct: 1048 LNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPP 1107

Query: 221  PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + K  ++  + A+G+AY++    +HRD+AARNC+      +
Sbjct: 1108 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV 1149


>UniRef50_B4DP99 cDNA FLJ51496, highly similar to Tyrosine-protein kinase CSK (EC
           2.7.10.2) n=6 Tax=Euteleostomi RepID=B4DP99_HUMAN
          Length = 399

 Score =  187 bits (475), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 49/198 (24%), Positives = 85/198 (42%), Gaps = 21/198 (10%)

Query: 73  DKIGFPTIIELVNHYVSTKESFSTKDGTVKAV-----LKQAVERQKWELYHEDVELTKKL 127
           +++ F  +++LV HY S  +   T+    K +      +    R  W L  ++++L + +
Sbjct: 91  EEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTI 150

Query: 128 GEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVV 187
           G+G FG+V  G              VAVK  K ++      +  + EA +M  L H N+V
Sbjct: 151 GKGEFGDVMLGDYRGN--------KVAVKCIKNDATA----QAFLAEASVMTQLRHSNLV 198

Query: 188 KFFGVAAGTEP-LYVIMELADGGALDSALGKLHFPMI---KKYELIYQAANGLAYIHEKN 243
           +  GV    +  LY++ E    G+L   L      ++      +        + Y+   N
Sbjct: 199 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 258

Query: 244 LMHRDVAARNCLYGGGQV 261
            +HRD+AARN L     V
Sbjct: 259 FVHRDLAARNVLVSEDNV 276


>UniRef50_B4LZ52 GJ23294 n=4 Tax=Coelomata RepID=B4LZ52_DROVI
          Length = 1966

 Score =  187 bits (475), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 46/158 (29%), Positives = 78/158 (49%), Gaps = 10/158 (6%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
              WE+  E +     LG+G+FG V++G L        + +  A+KT    +  +E+    
Sbjct: 1148 DDWEVPRERIIQLGPLGQGSFGMVYEGILKA--QNTGEDIPCAIKTVNENATDRERT-NF 1204

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-------FPMIK 224
            + EA +M+  D  +VV+  GV +  +P  V+MEL   G L S L            P  +
Sbjct: 1205 LSEASVMKEFDTYHVVRLLGVCSCGQPALVVMELMKKGDLKSYLRAHRPDEREDPPPYSR 1264

Query: 225  KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             +++  + A+G+AY+  K  +HRD+AARNC+      +
Sbjct: 1265 IFQMAIEIADGMAYLAAKKFVHRDLAARNCMVAEDLTV 1302


>UniRef50_Q52V39 Tyrosine-protein kinase receptor n=3 Tax=Branchiostoma floridae
           RepID=Q52V39_BRAFL
          Length = 797

 Score =  187 bits (475), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 54/162 (33%), Positives = 85/162 (52%), Gaps = 17/162 (10%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +  + +    +LGEGAFG V+ GK  K L  +    LVAVKT K  S+ ++  K+  REA
Sbjct: 505 IQRDTIHFVGELGEGAFGRVYLGKCEK-LKPDEDASLVAVKTLKEMSV-EDARKDFDREA 562

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---------------HF 220
            L+ N+ H N+VKF+GV    EP  +I E  + G L++ L                    
Sbjct: 563 ELLTNMQHENIVKFYGVCTEGEPWLMIFEYMENGDLNNYLRSHGPDAAFLIKNPATHKEL 622

Query: 221 PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            +++  ++  Q A+G+ Y+  ++ +HRD+A RNCL G   V+
Sbjct: 623 SIVELLQISVQVASGVEYMASQHFVHRDLATRNCLVGDKLVV 664


>UniRef50_Q9U2T8 Protein Y116A8C.38, partially confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=Q9U2T8_CAEEL
          Length = 528

 Score =  186 bits (474), Expect = 5e-46,   Method: Composition-based stats.
 Identities = 79/275 (28%), Positives = 138/275 (50%), Gaps = 32/275 (11%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           + L    YYHG++ R+ ++  L + G +L+R ++    E  +F+LS   +K+  + H  +
Sbjct: 63  RTLEGVSYYHGMVARDLVESKLTRCGDYLIRATDNRIME-FEFILSFFNKKRIHS-HLTI 120

Query: 64  RES--DHKV---YVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
           +      K     +    F ++++L N Y +               LK+A+ + K+ + H
Sbjct: 121 KCDVEAGKWALGLLSVNQFSSVVDLTNFYKTNPIG-------AGFFLKRAISKGKYMIAH 173

Query: 119 EDVELTKK---LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ-------- 167
           + ++ + K   LG G F +V++GK    ++  +Q V VA+KT KL   T +         
Sbjct: 174 DRIKYSPKDDLLGTGNFSDVFRGK----IELENQMVNVALKTTKLLDDTMDPTKNVKANK 229

Query: 168 -IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIK 224
             KE+++EA +M  L H NV  FFG+A    P+ +I+E  +GG L   L K        +
Sbjct: 230 IKKEMIQEAEVMSQLRHANVTSFFGIAVDRLPILLIIEFCNGGNLQGHLIKFGDRIGTNE 289

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
           ++  ++ A+ GL YIH  ++ HRD+AARNCL    
Sbjct: 290 RFLYLHDASAGLNYIHAMSITHRDIAARNCLISVN 324


>UniRef50_Q28WN9 GA20930 n=6 Tax=Drosophila RepID=Q28WN9_DROPS
          Length = 1705

 Score =  186 bits (474), Expect = 5e-46,   Method: Composition-based stats.
 Identities = 51/156 (32%), Positives = 79/156 (50%), Gaps = 13/156 (8%)

Query: 118  HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
             + ++L   LG+GAFGEV+   L +  D +   + VAVKT + E   +E+ ++ ++EA +
Sbjct: 1194 RDSLQLVNALGKGAFGEVYMA-LYRHRDGDAVEMGVAVKTLR-EDPKREKEEDFLKEAAI 1251

Query: 178  MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIKKYELI 229
            M   +H N+V   GV    +P Y+++EL  GG L   L +            M       
Sbjct: 1252 MAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCA 1311

Query: 230  YQAANGLAYIHEKNLMHRDVAARNCLY---GGGQVL 262
               A G  Y+  K  +HRD+AARNCL    G G+V+
Sbjct: 1312 LDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVV 1347


>UniRef50_Q8JG38 Fibroblast growth factor receptor 2 n=25 Tax=Euteleostomi
           RepID=FGFR2_DANRE
          Length = 817

 Score =  186 bits (474), Expect = 5e-46,   Method: Composition-based stats.
 Identities = 52/173 (30%), Positives = 78/173 (45%), Gaps = 20/173 (11%)

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKI-LDANHQPVLVAVKTAKLESMTKEQ 167
            E  +WE   + + L K LGEG FG+V   + L I  D   + V VAVK  K ++ T++ 
Sbjct: 465 PEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDA-TEKD 523

Query: 168 IKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP----- 221
           + +++ E  +M+ +  H N++   G      PLYVI+E A  G L   L     P     
Sbjct: 524 LSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 583

Query: 222 ------------MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                               YQ A G+ Y+  +  +HRD+AARN L     V+
Sbjct: 584 YDIARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVM 636


>UniRef50_B0XJJ2 Testis-specific serine/threonine-protein kinase 6 n=1 Tax=Culex
           quinquefasciatus RepID=B0XJJ2_CULQU
          Length = 590

 Score =  186 bits (474), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 54/163 (33%), Positives = 81/163 (49%), Gaps = 15/163 (9%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WEL  + + L K LGEGAFG V +GK     +  +  + VAVK  + E+ T E +K+++
Sbjct: 310 RWELPRQRIVLGKLLGEGAFGRVVQGKASGFAEGAN-SIPVAVKMLR-ENHTDEDVKDLV 367

Query: 173 REARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALG------------KLH 219
            E  +M+ +  H NV+   G  +   PLYVI+E A  G L + L             K  
Sbjct: 368 CELEIMKMIGKHPNVISLVGCCSNKGPLYVIIEYATHGNLKNFLRGFRFEGSFDKLDKQA 427

Query: 220 FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + +      Q A G+ Y+     +HRD+AARN L   G V+
Sbjct: 428 ISVQRLVTFALQIATGMEYLSSIKCIHRDLAARNILVSEGYVM 470


>UniRef50_Q05688 Insulin-like growth factor 1 receptor beta chain (Fragment) n=41
           Tax=Euteleostomi RepID=IGF1R_BOVIN
          Length = 640

 Score =  186 bits (474), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 48/162 (29%), Positives = 86/162 (53%), Gaps = 13/162 (8%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+  E + ++++LG+G+FG V++G    ++  +     VA+KT    +  +E+I E 
Sbjct: 263 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVK-DEPETRVAIKTVNEAASMRERI-EF 320

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-----------F 220
           + EA +M+  +  +VV+  GV +  +P  VIMEL   G L S L  L             
Sbjct: 321 LNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPP 380

Query: 221 PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + K  ++  + A+G+AY++    +HRD+AARNC+      +
Sbjct: 381 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV 422


>UniRef50_P34152 Focal adhesion kinase 1 n=16 Tax=Eutheria RepID=FAK1_MOUSE
          Length = 1090

 Score =  186 bits (473), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 52/155 (33%), Positives = 79/155 (50%), Gaps = 7/155 (4%)

Query: 110 ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
           E + +E+  E +EL + +GEG FG+V +G  L      +  + VA+KT K    +    +
Sbjct: 449 EARDYEIQRERIELGRCIGEGQFGDVHQGVYL---SPENPALAVAIKTCK-NCTSDSVRE 504

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYE 227
           + ++EA  MR  DH ++VK  GV     P+++IMEL   G L S L   K    +     
Sbjct: 505 KFLQEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKYSLDLASLIL 563

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             YQ +  LAY+  K  +HRD+AARN L      +
Sbjct: 564 YAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCV 598


>UniRef50_B3RWF6 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax
           adhaerens RepID=B3RWF6_TRIAD
          Length = 259

 Score =  186 bits (473), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 49/160 (30%), Positives = 82/160 (51%), Gaps = 19/160 (11%)

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
           +  +E+   D+++ K+LG G FG V+ G            + VAVK  K +SM++E   +
Sbjct: 1   KDIFEINRNDLQIGKQLGRGQFGVVYFGTYRN-------SIEVAVKMLKSDSMSEE---D 50

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---------HFP 221
            +REA++M  L H N+V+ +G+ +  +PL++I E    G L   L +             
Sbjct: 51  FLREAKVMHKLKHENLVQLYGICSIGKPLFIISEFMSRGCLLDYLREHFSSTTALSSQQT 110

Query: 222 MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
           +     +  Q  + + Y+ E N +HRD+AARNCL GG  +
Sbjct: 111 VEVLLNMALQICSAMLYLEENNFIHRDLAARNCLIGGTNI 150


>UniRef50_B2WR85 Fibroblast growth factor receptor B n=4 Tax=Nematostella vectensis
           RepID=B2WR85_NEMVE
          Length = 894

 Score =  186 bits (472), Expect = 8e-46,   Method: Composition-based stats.
 Identities = 47/168 (27%), Positives = 80/168 (47%), Gaps = 19/168 (11%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
           ++WEL    + L   LGEGAFG V K   + + +  ++   VAVK  K ++ T+ ++ ++
Sbjct: 487 EEWELDRSQISLLGILGEGAFGRVVKADAIGLPNMPYR-CNVAVKMLKEDA-TEHELADL 544

Query: 172 MREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALG-------------- 216
           + E  +M+ +  H+N++   G      PL+V++E A  G L   L               
Sbjct: 545 VSEMEVMKTIGQHVNIINLIGACTQKGPLFVVVEYASQGNLRQFLRARRPIPEYANPLTE 604

Query: 217 --KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             +    ++      YQ A G+ Y+  K  +HRD+AARN L     V+
Sbjct: 605 PPREKLKLVDLVSFSYQVARGMEYLESKKCIHRDLAARNVLVSDNHVI 652


>UniRef50_C9DED1 Fibroblast growth factor receptor B n=1 Tax=Saccoglossus
           kowalevskii RepID=C9DED1_SACKO
          Length = 928

 Score =  186 bits (472), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 48/171 (28%), Positives = 78/171 (45%), Gaps = 22/171 (12%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             WE+  + +EL + LGEGAFG+V K +   I     +   VAVK  K+ S T+ ++ ++
Sbjct: 532 PDWEIPRDKLELKEPLGEGAFGQVIKAEAKGIF-GKDKTTTVAVKMLKV-SATERELSDL 589

Query: 172 MREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK------ 224
           + E  +M+ +  H+N++   G +    PLYV++E A  G L   L     P         
Sbjct: 590 VHEMEMMKTIGKHLNIINLIGCSTQDGPLYVVVEFAPHGNLRDFLRSKRPPNPDYDCEKT 649

Query: 225 -------------KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                             YQ A  + ++  K  +HRD+AARN L     ++
Sbjct: 650 RLVNNYEPLLNKHLVSFAYQIAKAMEFLSSKRCIHRDLAARNVLVAENNIM 700


>UniRef50_Q170Z1 Tyrosine-protein kinase receptor (Fragment) n=1 Tax=Aedes aegypti
            RepID=Q170Z1_AEDAE
          Length = 2073

 Score =  185 bits (471), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 48/154 (31%), Positives = 77/154 (50%), Gaps = 13/154 (8%)

Query: 115  ELYHEDVELTKK--LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            ++  E + +T    LG GAFGEV++G +  +         VA+KT +  + T+++  E +
Sbjct: 1804 QIRREQISMTSSPFLGSGAFGEVYEGIVKGV--GGEAETRVAIKTLRKGA-TEQEKAEFL 1860

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIK 224
            +EA LM N  H +++K  GV    + LY++MEL  GG L S L              ++ 
Sbjct: 1861 QEAHLMSNFKHKHILKLIGVCLDLDSLYIVMELMQGGDLLSYLRSNRPTPGNPSMLTLLD 1920

Query: 225  KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
               +    A G  Y+ E + +HRD+A RNCL   
Sbjct: 1921 LISMCVDVATGCRYLEEMHFVHRDLACRNCLVSS 1954


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score =  185 bits (470), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 52/200 (26%), Positives = 95/200 (47%), Gaps = 28/200 (14%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           K +  + +Y G + R + ++ L    N+ G FL+R SE  + +   F LSV      +  
Sbjct: 140 KSIEAEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDSESRRND---FSLSV--RDGDTVK 194

Query: 60  HFVVRESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE------- 110
           H+ +R+ D   +    +  F T+ ELV+HY +  +            +++ +        
Sbjct: 195 HYRIRQLDEGGFFIARRTTFRTLQELVDHYGNEADGLCVNLRKPCVQVEKPMTSGLSHST 254

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
           R +WE+    ++  +KLG+G FGEVW+G         +    VA+KT K  +M     K+
Sbjct: 255 RDQWEIERSSLKFVRKLGQGQFGEVWEGLW-------NNTTPVAIKTLKPGTMDP---KD 304

Query: 171 IMREARLMRNLDHINVVKFF 190
            + EA++M+ L H  +V+ +
Sbjct: 305 FLAEAQIMKKLRHQKLVQLY 324


>UniRef50_P14616 Insulin receptor-related protein beta chain n=11 Tax=Eutheria
            RepID=INSRR_HUMAN
          Length = 1297

 Score =  185 bits (470), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 50/162 (30%), Positives = 86/162 (53%), Gaps = 13/162 (8%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             +WE+  E + + ++LG+G+FG V++G L + L+A  +   VA+KT    +  +E I E 
Sbjct: 970  DEWEVPREQISIIRELGQGSFGMVYEG-LARGLEAGEESTPVALKTVNELASPRECI-EF 1027

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP---------- 221
            ++EA +M+     +VV+  GV +  +P  VIMEL   G L S L  L             
Sbjct: 1028 LKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQP 1087

Query: 222  -MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + +  ++  + A+G+AY+     +HRD+AARNC+      +
Sbjct: 1088 ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTV 1129


>UniRef50_Q03351 NT-3 growth factor receptor n=21 Tax=Euteleostomi RepID=NTRK3_RAT
          Length = 864

 Score =  185 bits (470), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 51/164 (31%), Positives = 80/164 (48%), Gaps = 20/164 (12%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +   D+ L ++LGEGAFG+V+  +    L      +LVAVK  K    T    K+  REA
Sbjct: 533 IKRRDIVLKRELGEGAFGKVFLAECYN-LSPTKDKMLVAVKALK--DPTLAARKDFQREA 589

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG-----------------KL 218
            L+ NL H ++VKF+GV    +PL ++ E    G L+  L                  K 
Sbjct: 590 ELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKG 649

Query: 219 HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              + +   +  Q A+G+ Y+  ++ +HRD+A RNCL G   ++
Sbjct: 650 ELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV 693


>UniRef50_UPI0000EC9DFD Insulin receptor related tyrosine kinase n=1 Tax=Gallus gallus
           RepID=UPI0000EC9DFD
          Length = 972

 Score =  185 bits (470), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 49/162 (30%), Positives = 87/162 (53%), Gaps = 13/162 (8%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+  E + + ++LG+G+FG V++G  + ++ A  +   VA+KT    +  +E+I E 
Sbjct: 636 DEWEVSREKITVIRELGQGSFGMVYEGLAMGLV-AEGEETKVALKTVNELATMRERI-EF 693

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-----------F 220
           ++EA +M+     +VV+  GV +  +P  VIMEL   G L S L  L             
Sbjct: 694 LKEASVMKAFKCHHVVRLLGVVSQGQPALVIMELMTRGDLKSYLRSLRPDAENNPGLPPP 753

Query: 221 PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            +    ++  + A+G+AY++ K  +HRD+AARNC+      +
Sbjct: 754 SLKDMIQMAGEIADGMAYLNAKKFVHRDLAARNCMVSEDFTV 795


>UniRef50_B8JIA2 Fibroblast growth factor receptor 3 (Fragment) n=4 Tax=Coelomata
           RepID=B8JIA2_DANRE
          Length = 497

 Score =  185 bits (470), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 51/191 (26%), Positives = 78/191 (40%), Gaps = 20/191 (10%)

Query: 91  KESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN-HQ 149
           + S S           +     KWE     + L K LGEG FG+V   + + I     ++
Sbjct: 127 RLSSSDGPMLPNVSELELPSDPKWEFTRTKLTLGKPLGEGCFGQVVMAEAIGIDKEKPNK 186

Query: 150 PVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADG 208
           P+ VAVK  K +   K+ + +++ E  +M+ +  H N++   G      PLYV++E A  
Sbjct: 187 PLTVAVKMLKDDGTDKD-LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASK 245

Query: 209 GALDSALG-----------------KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAA 251
           G L   L                               YQ A G+ Y+  K  +HRD+AA
Sbjct: 246 GNLREYLRARRPPGMDYSFDTCKIPNETLTFKDLVSCAYQVARGMEYLASKKCIHRDLAA 305

Query: 252 RNCLYGGGQVL 262
           RN L     V+
Sbjct: 306 RNVLVTEDNVM 316


>UniRef50_Q59FL9 Fibroblast growth factor receptor 3 isoform 1 variant (Fragment)
           n=14 Tax=Mammalia RepID=Q59FL9_HUMAN
          Length = 879

 Score =  185 bits (470), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 51/170 (30%), Positives = 77/170 (45%), Gaps = 20/170 (11%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKI-LDANHQPVLVAVKTAKLESMTKEQIKE 170
            KWEL    + L K LGEG FG+V   + + I  D   +PV VAVK  K ++  K+ + +
Sbjct: 551 PKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD-LSD 609

Query: 171 IMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALG------------- 216
           ++ E  +M+ +  H N++   G      PLYV++E A  G L   L              
Sbjct: 610 LVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT 669

Query: 217 ----KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               +            YQ A G+ Y+  +  +HRD+AARN L     V+
Sbjct: 670 CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVM 719


>UniRef50_A3KPS2 Tyrosine-protein kinase receptor (Fragment) n=11 Tax=Clupeocephala
           RepID=A3KPS2_DANRE
          Length = 853

 Score =  185 bits (470), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 48/163 (29%), Positives = 81/163 (49%), Gaps = 19/163 (11%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +   ++ L ++LGEGAFG+V+  +    L  + + +LVAVKT K    ++    +  REA
Sbjct: 562 IKRHNILLKRELGEGAFGKVFLAECYN-LSPDQEKILVAVKTLKE--ASESGRADFHREA 618

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL----------------H 219
            L+ NL H ++VKF+GV   ++PL ++ E    G L+  L                    
Sbjct: 619 ELLTNLQHEHIVKFYGVCVESDPLIMVFEYMKHGDLNKFLRAHGPDAVLMADGQQSLLVE 678

Query: 220 FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               +   +  Q A G+ Y+  ++ +HRD+A RNCL G   ++
Sbjct: 679 LTQPQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV 721


>UniRef50_UPI000180B27C PREDICTED: similar to proto-oncogene c-ros, partial n=1 Tax=Ciona
           intestinalis RepID=UPI000180B27C
          Length = 1050

 Score =  184 bits (469), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 46/152 (30%), Positives = 72/152 (47%), Gaps = 10/152 (6%)

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
             + ++L   +G GAFGEV+KG    I     +   VAVKT K +  ++ +  E + EA 
Sbjct: 598 PRDQLKLGMLIGSGAFGEVYKGTAAGISGGEGEA-SVAVKTLK-DGASENEKMEFLMEAY 655

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--------LHFPMIKKYEL 228
            M   DH N++   GV    EP ++I+EL +GG L   L               +   ++
Sbjct: 656 FMSLFDHRNIISLLGVCLDNEPQFLILELMEGGDLLKYLRHARPTQMMSSKLSFLDLIDI 715

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
               + G  Y+  ++ +HRD+AARNCL     
Sbjct: 716 CLDLSAGCKYLESQHFIHRDLAARNCLVSSKD 747


>UniRef50_UPI000180BC98 PREDICTED: similar to V-yes-1 Yamaguchi sarcoma viral oncogene
           homolog 1 n=1 Tax=Ciona intestinalis RepID=UPI000180BC98
          Length = 432

 Score =  184 bits (468), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 65/274 (23%), Positives = 114/274 (41%), Gaps = 36/274 (13%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           + +  +  Y G + RE+ +  L       G FL+R      GE R  +LS   +      
Sbjct: 18  ETIESEPCYFGTISREEAETNLLERGENDGTFLVRKG--TDGEYRISLLSSTSDGSCRVY 75

Query: 60  HFVVRESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
           ++ V+ + ++ Y   D   FP + +LV +Y        +K   V    K+ +E++    +
Sbjct: 76  NYRVKLATNRTYSIDDTYSFPAVHQLVRYYSQKCSGLPSK--LVAPCPKEDLEKEPESGF 133

Query: 118 H--------EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
           H          VE+  +L  G++ E+WK   L+           A K A     T     
Sbjct: 134 HPLLPVIAGSSVEMRSQLSCGSYSEIWKANYLR--------TTFAAKCALSNHCT----- 180

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMIKKY 226
            +++EA +MR L H NVV+  GV    EP  ++ +      L   +    K       + 
Sbjct: 181 LLVKEANIMRELRHNNVVQISGVIL--EPQTIVFDYYPNRDLLDYMLRGEKYEMTNYHRT 238

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
           ++  Q A+GL YI ++ ++HR++ A N L     
Sbjct: 239 QMAIQVASGLEYISKRGIIHRNIRASNILVDQNL 272


>UniRef50_UPI00017B4565 UPI00017B4565 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B4565
          Length = 992

 Score =  184 bits (468), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 46/163 (28%), Positives = 76/163 (46%), Gaps = 6/163 (3%)

Query: 98  DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKT 157
           D         AV +   E++   +   K +G G FGEV++G L        +   VA+KT
Sbjct: 607 DPHTYEDPNTAVMKFATEIHPSHIAKEKVIGAGEFGEVYRGILK---VPGRKESAVAIKT 663

Query: 158 AKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK 217
            K    T++Q ++ + EA +M    H N+++  GV    +   +I E  + GALD  L  
Sbjct: 664 LKPG-YTEKQRQDFLSEASIMGQFAHQNIIRLEGVVTKFKHAMIITEYMENGALDRYLRD 722

Query: 218 L--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
               F   +   ++   A G+ Y+ + + +HRD+AARN L   
Sbjct: 723 HDGEFTSFQLVGMLRGIAAGMKYLSDMSYVHRDLAARNILVNN 765


>UniRef50_UPI0001A2C9CC UPI0001A2C9CC related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2C9CC
          Length = 388

 Score =  184 bits (468), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 63/268 (23%), Positives = 109/268 (40%), Gaps = 34/268 (12%)

Query: 11  YYHGLL-PREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEK---KTSANHFV 62
           +Y   +  R + +  L    NK G FL+   +    E   + LS    K      A H+ 
Sbjct: 1   WYFENVKTRVEAKRCLLRPENKEGAFLVWKCD----ENNHYYLSGKVHKVKNGPHARHYR 56

Query: 63  VR--ESDHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER-----QKW 114
           ++  E+D + ++     F ++ +L+  Y   +     K       L Q V +      K 
Sbjct: 57  IKQGENDQQFFLVHHTTFQSLRKLIEFYSKHEGGLCAKLHEACVKLDQPVPQTLSFDSKC 116

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+    +   +KLG G F +VW+G         +    VA+K  K   M      +I  E
Sbjct: 117 EIDRSSLTKQQKLGSGEFADVWQGLW-------NNTTEVAIKEFK--GMGGVNYSDIQTE 167

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL----GKLHFPMIKKYELIY 230
             +M++L H  ++K + V   ++P+ ++ EL   G+L + L     K         +   
Sbjct: 168 IEIMKDLHHERLLKLYAVCTTSQPMCIVTELMKNGSLKTFLLRHKEKQDLEFSLMLDFAI 227

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGG 258
           Q   G+ YI  K ++HRD+ A N L   
Sbjct: 228 QITEGMIYIENK-IVHRDLRAENILLTE 254


>UniRef50_UPI000186EA5D proto-oncogene receptor tyrosine protein kinase ret, putative n=1
           Tax=Pediculus humanus corporis RepID=UPI000186EA5D
          Length = 870

 Score =  184 bits (467), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 55/188 (29%), Positives = 92/188 (48%), Gaps = 24/188 (12%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           S ++GT+K + +     +KWE     + + + LGEG FG+V K K   I   N     VA
Sbjct: 432 SVQNGTIKEISEHY--DKKWEFPRYRLTIEEILGEGEFGKVLKAKADGIG-GNPGSTTVA 488

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE-PLYVIMELADGGALDS 213
           VKT K ++  + ++ ++M E +L++++DH NV+   G    ++ P+Y+I+E A  G+L +
Sbjct: 489 VKTLKDDAK-ETELSDLMSEYQLLKDIDHPNVIHLLGACTKSDGPVYIIIEYAKHGSLRN 547

Query: 214 ALGKLH-------------------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNC 254
            L K                               +Q A G+ Y+ +  L+HRD+AARN 
Sbjct: 548 YLRKHRAAIIEQLNHNDNNMGVEKNVTPKDLLTFAWQIAKGMNYLTDMKLVHRDLAARNI 607

Query: 255 LYGGGQVL 262
           L   G + 
Sbjct: 608 LVAEGLIC 615


>UniRef50_Q16288 NT-3 growth factor receptor n=57 Tax=Euteleostomi RepID=NTRK3_HUMAN
          Length = 839

 Score =  184 bits (467), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 51/164 (31%), Positives = 80/164 (48%), Gaps = 20/164 (12%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +   D+ L ++LGEGAFG+V+  +    L      +LVAVK  K    T    K+  REA
Sbjct: 533 IKRRDIVLKRELGEGAFGKVFLAECYN-LSPTKDKMLVAVKALK--DPTLAARKDFQREA 589

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG-----------------KL 218
            L+ NL H ++VKF+GV    +PL ++ E    G L+  L                  K 
Sbjct: 590 ELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKG 649

Query: 219 HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              + +   +  Q A+G+ Y+  ++ +HRD+A RNCL G   ++
Sbjct: 650 ELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV 693


>UniRef50_Q4SMF1 Chromosome 8 SCAF14552, whole genome shotgun sequence. (Fragment)
           n=13 Tax=Clupeocephala RepID=Q4SMF1_TETNG
          Length = 714

 Score =  184 bits (467), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 7/182 (3%)

Query: 84  VNHYVSTKESFSTK-DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLK 142
           +  Y+S +       D +      +AV+    E+    +++ + +G   FGEV +G+   
Sbjct: 315 LQRYISNRGGVKYYVDPSTYEDPSEAVKEFAREIDPTHLKIEEVIGAAQFGEVSRGRYRP 374

Query: 143 ILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVI 202
           +     + VLVAVKT +  +  +E+    + EA ++   DH NV+K  GV   T P  ++
Sbjct: 375 L---GRREVLVAVKTLRWGASDREK-GMFLSEAGVLGQFDHPNVLKLEGVITRTPPERIV 430

Query: 203 MELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
            E  + G LDS L +    F +++   ++     G+ Y+ E+N +HRD+AARN L     
Sbjct: 431 TEFMENGPLDSFLRENEGQFSVLQLVGMLRGIGAGMRYLAERNFVHRDLAARNVLVNSNL 490

Query: 261 VL 262
           V 
Sbjct: 491 VC 492


>UniRef50_A9RMB5 Predicted protein n=12 Tax=Viridiplantae RepID=A9RMB5_PHYPA
          Length = 582

 Score =  184 bits (467), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 44/177 (24%), Positives = 84/177 (47%), Gaps = 10/177 (5%)

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
           V  + +   ++G + A    +     WE+ +  ++ T+K+  G+FG++++G         
Sbjct: 262 VVHETAVHPENGQIPAPALPSTGTDDWEIDYNQLKFTQKVANGSFGDLFQGTYCGQ---- 317

Query: 148 HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELAD 207
                VA+K  K E + +   +E ++E R+MR + H NVV+F G       L ++ E   
Sbjct: 318 ----DVAIKILKPERLNENLQREFLQEIRIMRKVRHKNVVQFIGACTKPPNLCIVTEFMS 373

Query: 208 GGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           GG++   L K      M     +    + G+ Y+H+  ++HRD+ A N L    +V+
Sbjct: 374 GGSVYDYLHKQKAVLKMPMLLRVAIDISKGMDYLHQNKIIHRDLKAANLLMDENEVV 430


>UniRef50_UPI000186E417 tyrosine-protein kinase transmembrane receptor ROR1 precursor,
           putative n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186E417
          Length = 932

 Score =  184 bits (467), Expect = 4e-45,   Method: Composition-based stats.
 Identities = 49/159 (30%), Positives = 76/159 (47%), Gaps = 14/159 (8%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E    +V+  ++LGEGAFG+V+KG++   +      + VA+KT K  +  K Q ++  RE
Sbjct: 479 EYQLSNVKFLEELGEGAFGKVYKGEI--HVSKTDPVLQVAIKTLKENATLKTQ-QDFRRE 535

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL-----------GKLHFPMI 223
             LM  L H N+V   GV    +P  ++ E    G L   L           G       
Sbjct: 536 VELMSELRHPNIVCLLGVVKRQQPYAMLFEYMTQGDLHEYLMVHSPRSADDNGGHILDQQ 595

Query: 224 KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +  ++  Q A G+ Y+   + +HRD+AARNCL G    +
Sbjct: 596 EFLQIALQIAAGMDYLSSHHYVHRDLAARNCLVGDNLTV 634


>UniRef50_C4Q5Z3 Ephrin receptor, putative n=1 Tax=Schistosoma mansoni
           RepID=C4Q5Z3_SCHMA
          Length = 1148

 Score =  183 bits (466), Expect = 4e-45,   Method: Composition-based stats.
 Identities = 41/150 (27%), Positives = 78/150 (52%), Gaps = 5/150 (3%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+    + +   +GEG FG+V  G    I    ++  LVA+K    + ++++  ++ + E
Sbjct: 708 EIDPRRIMIRSTIGEGEFGKVCAGDF--ITTDENKVQLVAIKMLHPD-VSEKTRQDFLTE 764

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELIYQA 232
           A ++  LDH N+V+  G+   +EP  +++E  + G+LD+ L +      M +   ++   
Sbjct: 765 ANILSQLDHPNIVQLIGLVIKSEPKMIVIEFMENGSLDNYLRRNGNTLSMEQLLYMLRDI 824

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           A G+ Y+   N +HRD+AARN L     + 
Sbjct: 825 ACGMNYLSHLNYVHRDLAARNILVDKFNIC 854


>UniRef50_Q7QIP0 AGAP006988-PA n=5 Tax=Endopterygota RepID=Q7QIP0_ANOGA
          Length = 699

 Score =  183 bits (466), Expect = 4e-45,   Method: Composition-based stats.
 Identities = 50/165 (30%), Positives = 79/165 (47%), Gaps = 16/165 (9%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
           +K E    ++   K LG+GAFG V++ K   ++ A     LVAVK  K E+ +++   + 
Sbjct: 407 EKLEFPRNNIIYIKDLGQGAFGRVFQAKAPGLV-AGEDFTLVAVKMLKDEA-SQDLQVDF 464

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL------------- 218
            REA L+   DH N+VK  GV A   P+ ++ E    G L+  L +              
Sbjct: 465 EREACLLAEFDHPNIVKLLGVCAIGRPMCLLFEFMARGDLNEFLRQCSPFAQQNRADSIS 524

Query: 219 -HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                     + +Q A+G+ Y+ E+  +HRD+A RNCL     V+
Sbjct: 525 TELSHGDLLNIAHQIASGMVYLSERKFVHRDLATRNCLIDDHMVV 569


>UniRef50_A8WVF6 Putative uncharacterized protein n=2 Tax=root RepID=A8WVF6_CAEBR
          Length = 579

 Score =  183 bits (466), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 76/287 (26%), Positives = 127/287 (44%), Gaps = 39/287 (13%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRT------------------------- 35
           M    L    Y+HG +   + +EML   G FL+R                          
Sbjct: 1   MEMTTLTSLPYFHGTIDTRECREMLPDLGDFLIRNPTNEMVKSGGTRTFACILTTAVTPD 60

Query: 36  --SEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKES 93
             SE  K   + + L +    +  +   ++    + +      + ++ EL N Y S++++
Sbjct: 61  QASENSKMLPKDYSLRLECTTRLKSYGIILENGVYSLLGTPETYQSVEELCNAYTSSRKA 120

Query: 94  FSTKDGTVKAVLKQAVERQKWELYHEDVEL---TKKLGEGAFGEVWKGKLLKILDANHQP 150
           F      +     + V R+ W+L   D+E       LG G FG+V +GKLL+       P
Sbjct: 121 FPQGGMAL-----RPVARRPWQLLLSDIEFPVPEVVLGSGEFGKVIRGKLLRHGVP---P 172

Query: 151 VLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGA 210
           + VA+K A  E+   E I E+  EAR MR L H N+++F GV     PLY+++E  +G +
Sbjct: 173 IDVALKRATAENH-AEIISEMFTEARAMRALMHPNIIRFEGVVVEKLPLYLVIEFLEGSS 231

Query: 211 LDSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
           L  AL K     + ++ +       + ++H  N +HRD+AARN +  
Sbjct: 232 LLDALRKKKVNNVYRFPICMAVLYAVLWMHMHNYIHRDIAARNVMIS 278


>UniRef50_Q16832 Discoidin domain-containing receptor 2 n=50 Tax=Chordata
           RepID=DDR2_HUMAN
          Length = 855

 Score =  183 bits (465), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 46/169 (27%), Positives = 77/169 (45%), Gaps = 22/169 (13%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILD----------ANHQPVLVAVKTAKLESMT 164
           E   + +   +KLGEG FGEV   ++  +            + +QPVLVAVK  + ++  
Sbjct: 557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA-N 615

Query: 165 KEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK 224
           K    + ++E ++M  L   N++    V    +PL +I E  + G L+  L +   P   
Sbjct: 616 KNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSS 675

Query: 225 KYE-----------LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             +           +  Q A+G+ Y+   N +HRD+A RNCL G    +
Sbjct: 676 SSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI 724


>UniRef50_C3XPN4 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3XPN4_BRAFL
          Length = 585

 Score =  183 bits (465), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 52/150 (34%), Positives = 79/150 (52%), Gaps = 7/150 (4%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESM-TKEQIKEIMRE 174
           +  +++ L +KLG+G+FG V KG            + VAVK  K E +   +   + ++E
Sbjct: 12  ISEKELCLYEKLGDGSFGVVRKGDWTT---PGGCTIPVAVKCLKNEVLVQPDAFMDFVKE 68

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELIYQA 232
              M  LDH N+++ +GV   + PL ++ ELA  GAL   L K    FP+    E   Q 
Sbjct: 69  VNAMHQLDHPNLIRLYGVVLSS-PLMMVTELAPKGALLDKLRKAGHRFPIATLCEYAIQI 127

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           ANG+AY+     +HRD+AARN L    +V+
Sbjct: 128 ANGMAYLESHRYIHRDLAARNILLASNEVV 157


>UniRef50_P07949 Proto-oncogene tyrosine-protein kinase receptor Ret n=73
           Tax=Eumetazoa RepID=RET_HUMAN
          Length = 1114

 Score =  183 bits (465), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 51/197 (25%), Positives = 89/197 (45%), Gaps = 27/197 (13%)

Query: 89  STKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANH 148
           + + S  + +  V     + +E  KWE   +++ L K LGEG FG+V K      L    
Sbjct: 692 ARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF-HLKGRA 750

Query: 149 QPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADG 208
               VAVK  K E+ +  ++++++ E  +++ ++H +V+K +G  +   PL +I+E A  
Sbjct: 751 GYTTVAVKMLK-ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKY 809

Query: 209 GALDSALGKLH-------------------------FPMIKKYELIYQAANGLAYIHEKN 243
           G+L   L +                             M       +Q + G+ Y+ E  
Sbjct: 810 GSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMK 869

Query: 244 LMHRDVAARNCLYGGGQ 260
           L+HRD+AARN L   G+
Sbjct: 870 LVHRDLAARNILVAEGR 886


>UniRef50_C3Y1A6 Putative uncharacterized protein (Fragment) n=1 Tax=Branchiostoma
           floridae RepID=C3Y1A6_BRAFL
          Length = 977

 Score =  183 bits (465), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 48/149 (32%), Positives = 78/149 (52%), Gaps = 7/149 (4%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
           + +E+  + + L   +GEG FG+V +G      + N   + VAVKT K++  T    ++ 
Sbjct: 412 KDYEIARDKIVLGAIIGEGQFGDVHRGVYKSKEEGN---LDVAVKTCKMD-CTDTVAEKF 467

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELI 229
           + EA  M+  DH ++++  GV     P+++IMELA+ G L S L   K    +       
Sbjct: 468 LEEAYTMKQFDHPHIIRLIGVCTDR-PIWIIMELANFGELRSFLQSNKQSLDLATLILYA 526

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           YQ +  L+Y+  K  +HRD+AARN L   
Sbjct: 527 YQLSTALSYLESKKFVHRDIAARNVLVAA 555


>UniRef50_Q4RM64 Chromosome 10 SCAF15019, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Tetraodontidae RepID=Q4RM64_TETNG
          Length = 410

 Score =  183 bits (464), Expect = 7e-45,   Method: Composition-based stats.
 Identities = 48/150 (32%), Positives = 85/150 (56%), Gaps = 10/150 (6%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+  +++ L + LG GAFGEV++G+LL  ++ +++P+ VA+KT   E  +++   + + E
Sbjct: 54  EVPRKNITLLRALGHGAFGEVYEGQLLG-MNNDNKPMQVAIKTL-PEICSEQDEMDFLME 111

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIKKY 226
           A +M    H N+V+  GV+    P ++++EL  GG + S L +            M +  
Sbjct: 112 ALIMSKFSHENIVRCIGVSLNILPRFILLELMTGGDMKSFLRQNRPRAGQTSLLSMRELL 171

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLY 256
           ++    A G  Y+ E + +HRD+AARNCL 
Sbjct: 172 QMARDIAFGCRYLEENHFIHRDIAARNCLL 201


>UniRef50_Q4RXA0 Chromosome 11 SCAF14979, whole genome shotgun sequence. (Fragment)
           n=4 Tax=Euteleostomi RepID=Q4RXA0_TETNG
          Length = 1042

 Score =  183 bits (464), Expect = 7e-45,   Method: Composition-based stats.
 Identities = 45/170 (26%), Positives = 77/170 (45%), Gaps = 6/170 (3%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           S  D  +      A+++   E+    +   K +G G FGEV++G +          V VA
Sbjct: 656 SYVDPHMYEDPNIAIQKFVTEIDPSAISKQKVIGVGEFGEVFRGVMKTRGQG---EVNVA 712

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           +KT K    +++Q  + + EA +M    H N++   GV    + + ++ E  D GALD+ 
Sbjct: 713 IKTLKPG-YSEKQRLDFLSEASIMGQFSHPNIIHLEGVVTKFKHIMIVTEYMDNGALDTY 771

Query: 215 L--GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L       P  +   ++   A G+ Y+   + +HRD+AARN L       
Sbjct: 772 LKGRDGEIPPYQLVGMLRGIAAGMQYLSNMSYVHRDLAARNILVNSNLEC 821


>UniRef50_Q4S1S8 Chromosome undetermined SCAF14764, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4S1S8_TETNG
          Length = 635

 Score =  183 bits (464), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 48/168 (28%), Positives = 78/168 (46%), Gaps = 20/168 (11%)

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKI-LDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           WEL  + + L K LGEG FG+V   + + +  +   +   VAVK  K ++ T++   +++
Sbjct: 341 WELPRDRLTLGKPLGEGCFGQVVLAEAVGLDKNKPARVTKVAVKMLKADA-TEKDRADLI 399

Query: 173 REARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH------------ 219
            E  +M+ +  H N++   G      PLYV++E A  G L   L                
Sbjct: 400 SEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLRDYLRARRPAGLEYWSSSRP 459

Query: 220 -----FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                  +++     YQ A G+AY+  K  +HRD+AARN L     V+
Sbjct: 460 VSLASMEIMELVSAAYQVARGMAYLASKKCIHRDLAARNVLVTEDNVM 507


>UniRef50_B3RT16 Tyrosine-protein kinase receptor (Fragment) n=1 Tax=Trichoplax
           adhaerens RepID=B3RT16_TRIAD
          Length = 449

 Score =  183 bits (464), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 51/167 (30%), Positives = 86/167 (51%), Gaps = 18/167 (10%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             WE   E + L K+LG+GAFG V+ G+   I+    +   VAVKT   ++  +E+ +E 
Sbjct: 5   DDWEFEREKIALLKELGKGAFGMVYLGEAADIIYGELK-TKVAVKTVNEKASFRER-QEF 62

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHF----------- 220
           + EA +M+  D  +VV+  G+ +   P  VIMEL   G L + L  L             
Sbjct: 63  LNEACIMKQFDCNHVVRLLGIVSQGLPPLVIMELMANGDLKNHLRSLREDADSPDYYLKP 122

Query: 221 -----PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                  ++ +++  + A+G+ Y+ +K  +HRD+AARNC+  G  ++
Sbjct: 123 NPNRPSDVQFHKMAAEIADGMLYLSDKKFVHRDLAARNCMVSGDFIV 169


>UniRef50_Q2LC18 Tyrosine-protein kinase receptor (Fragment) n=2
           Tax=Strongylocentrotus purpuratus RepID=Q2LC18_STRPU
          Length = 1072

 Score =  182 bits (463), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 52/193 (26%), Positives = 94/193 (48%), Gaps = 20/193 (10%)

Query: 80  IIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGK 139
           + + V +     E  ST D  V           +WE   + +E+ ++LG+G+FG V++G 
Sbjct: 667 MPDGVLYASVNPEYMSTSDMYVA---------DEWEFPRDKLEIIRELGKGSFGMVYEGL 717

Query: 140 LLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPL 199
              IL    +   VA+K+ +  +  +++I E + EA +M+ +D  NVV+  GV +  +P 
Sbjct: 718 AKGILPEEEEISRVAIKSVQANASMRDRI-EFLNEASVMKLIDAHNVVRLLGVVSKGQPT 776

Query: 200 YVIMELADGGALDSALGKLH----------FPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
           YVIME    G L + L                + +   +  + A+G++++  +  +HRD+
Sbjct: 777 YVIMEFMAQGDLKNWLRARRPENQQDLPSVPTLEQLLNMAAEIADGMSFLAARKYVHRDL 836

Query: 250 AARNCLYGGGQVL 262
           +ARNCL  G    
Sbjct: 837 SARNCLVSGEGTC 849


>UniRef50_C9DED0 Fibroblast growth factor receptor A n=2 Tax=Saccoglossus
           kowalevskii RepID=C9DED0_SACKO
          Length = 748

 Score =  182 bits (462), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 49/171 (28%), Positives = 78/171 (45%), Gaps = 21/171 (12%)

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQP--VLVAVKTAKLESMTKEQIK 169
           +KWE     + + K LGEGAFG+V + + + I+    +     VAVK  K ++ T+ ++ 
Sbjct: 414 EKWEFPRNRLCIGKMLGEGAFGQVLEAEAVGIMKDGSKTSNTTVAVKMLKSDA-TERELS 472

Query: 170 EIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------- 219
           +++ E  +MR +  HIN++   G      PL VI+E A  G L   L             
Sbjct: 473 DLISEMIMMRQIGKHINIINLIGCVTQDGPLLVIVEYAPQGNLREFLRCRRPQNMDYENA 532

Query: 220 --------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                             YQ + G+ ++  K  +HRD+AARN L G   V+
Sbjct: 533 SLLPQVELLSNKDLVSFAYQISRGMEFLSSKKCVHRDLAARNVLVGENNVM 583


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q18865 Putative uncharacterized protein n=6 Tax=Caenorh...   348   1e-94
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   334   2e-90
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   334   2e-90
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...   332   7e-90
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   329   6e-89
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   328   9e-89
UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA    328   1e-88
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...   328   1e-88
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   327   3e-88
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   326   6e-88
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          325   1e-87
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          325   1e-87
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   325   1e-87
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...   324   2e-87
UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateri...   321   1e-86
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   320   3e-86
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   320   3e-86
UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, part...   318   1e-85
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   318   2e-85
UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1...   317   2e-85
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...   317   2e-85
UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=...   317   2e-85
UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorh...   317   3e-85
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   315   1e-84
UniRef50_C4Q4A1 Term=tyrosine kinase 5;db_xref=PMID:11289068;wit...   314   2e-84
UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria...   313   3e-84
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   313   3e-84
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...   313   3e-84
UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepI...   312   7e-84
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...   311   1e-83
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...   311   1e-83
UniRef50_Q18684 Protein T13H10.1, confirmed by transcript eviden...   310   2e-83
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...   310   4e-83
UniRef50_UPI000186DA97 tyrosine-protein kinase transforming prot...   310   5e-83
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   309   5e-83
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...   309   6e-83
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...   309   7e-83
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...   308   9e-83
UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephyd...   307   3e-82
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   307   3e-82
UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni ...   306   6e-82
UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera...   306   6e-82
UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax...   305   1e-81
UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76...   305   1e-81
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   304   1e-81
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...   304   2e-81
UniRef50_P34265 Probable tyrosine-protein kinase kin-31 n=4 Tax=...   303   5e-81
UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Su...   303   5e-81
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...   302   7e-81
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...   302   9e-81
UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax...   302   9e-81
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   301   1e-80
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...   300   3e-80
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...   299   5e-80
UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes relate...   299   6e-80
UniRef50_Q20933 Putative uncharacterized protein n=1 Tax=Caenorh...   298   1e-79
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...   298   2e-79
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...   297   2e-79
UniRef50_Q7YSY1 Fes-like tyrosine kinase protein n=5 Tax=Schisto...   293   4e-78
UniRef50_Q4S351 Chromosome 4 SCAF14752, whole genome shotgun seq...   293   4e-78
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...   292   9e-78
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...   292   1e-77
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...   291   2e-77
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...   291   2e-77
UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata R...   290   2e-77
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE     289   5e-77
UniRef50_A8WMP8 Putative uncharacterized protein n=1 Tax=Caenorh...   289   5e-77
UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia mal...   288   1e-76
UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax...   287   2e-76
UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative ...   287   3e-76
UniRef50_A8PMN8 Protein kinase domain containing protein n=1 Tax...   286   4e-76
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...   286   4e-76
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   286   5e-76
UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun se...   285   8e-76
UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein ...   284   1e-75
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   283   6e-75
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...   282   1e-74
UniRef50_Q9TYX4 Putative uncharacterized protein R11E3.1 n=3 Tax...   280   4e-74
UniRef50_Q23554 Putative uncharacterized protein n=1 Tax=Caenorh...   280   4e-74
UniRef50_O01798 Defective spermatogenesis protein 8 n=3 Tax=Caen...   279   6e-74
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...   278   1e-73
UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona inte...   277   2e-73
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...   277   2e-73
UniRef50_O17755 Protein F01D4.3, partially confirmed by transcri...   276   4e-73
UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidenc...   276   7e-73
UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes...   274   2e-72
UniRef50_Q9N4T6 Putative uncharacterized protein n=1 Tax=Caenorh...   274   2e-72
UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   273   3e-72
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...   273   3e-72
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...   273   4e-72
UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosi...   273   4e-72
UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2...   273   6e-72
UniRef50_P91360 Putative uncharacterized protein n=3 Tax=root Re...   269   7e-71
UniRef50_UPI00004D86FC Tyrosine-protein kinase Tec (EC 2.7.10.2)...   268   2e-70
UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californic...   267   2e-70
UniRef50_UPI0000ECD739 Cytoplasmic tyrosine-protein kinase BMX (...   265   1e-69
UniRef50_Q19726 Protein F22D6.1, partially confirmed by transcri...   264   3e-69
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...   262   8e-69
UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Tak...   259   5e-68
UniRef50_A8XFQ1 Putative uncharacterized protein n=2 Tax=Caenorh...   259   6e-68
UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni ...   259   7e-68
UniRef50_A8Q767 Protein kinase domain containing protein n=1 Tax...   258   1e-67
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...   258   1e-67
UniRef50_A8PJL3 Protein kinase domain containing protein n=1 Tax...   258   2e-67
UniRef50_A8Q7I8 Protein kinase domain containing protein n=1 Tax...   257   4e-67
UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase...   256   5e-67
UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia ...   255   1e-66
UniRef50_Q22765 Protein T25B9.4, partially confirmed by transcri...   254   2e-66
UniRef50_A8QBK0 Protein kinase domain containing protein n=1 Tax...   252   8e-66
UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n...   251   1e-65
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...   251   2e-65
UniRef50_B4DSE0 Ephrin receptor n=19 Tax=Euteleostomi RepID=B4DS...   251   2e-65
UniRef50_C4Q0E9 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   251   2e-65
UniRef50_UPI0001757DA5 PREDICTED: similar to insulin receptor, p...   249   9e-65
UniRef50_Q9U3B5 Protein K09B11.5a, confirmed by transcript evide...   249   9e-65
UniRef50_Q21299 Protein W08D2.8, partially confirmed by transcri...   247   2e-64
UniRef50_A8NEQ9 Protein kinase domain containing protein (Fragme...   247   2e-64
UniRef50_Q9XW34 Protein Y69E1A.3, partially confirmed by transcr...   247   3e-64
UniRef50_A8WSQ7 Putative uncharacterized protein n=2 Tax=Caenorh...   246   8e-64
UniRef50_Q4RVA1 Chromosome 15 SCAF14992, whole genome shotgun se...   245   1e-63
UniRef50_UPI000194BA20 PREDICTED: EPH receptor A3 n=2 Tax=Eutele...   243   3e-63
UniRef50_Q6PFV6 Ephrin receptor n=8 Tax=Amniota RepID=Q6PFV6_MOUSE    243   5e-63
UniRef50_UPI00005A03D8 PREDICTED: similar to Ephrin type-A recep...   242   7e-63
UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine ki...   242   8e-63
UniRef50_P29323 Ephrin type-B receptor 2 n=364 Tax=Eumetazoa Rep...   242   1e-62
UniRef50_P54756 Ephrin type-A receptor 5 n=102 Tax=Euteleostomi ...   241   2e-62
UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine ki...   240   3e-62
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   240   4e-62
UniRef50_Q07497 Ephrin type-B receptor 5 n=68 Tax=Euteleostomi R...   239   9e-62
UniRef50_Q4SQX3 Chromosome 11 SCAF14528, whole genome shotgun se...   239   9e-62
UniRef50_Q23102 Protein W01B6.5, partially confirmed by transcri...   238   1e-61
UniRef50_Q4RV12 Ephrin receptor (Fragment) n=3 Tax=Euteleostomi ...   238   2e-61
UniRef50_P29317 Ephrin type-A receptor 2 n=31 Tax=Euteleostomi R...   237   2e-61
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...   237   3e-61
UniRef50_UPI0000DB7426 PREDICTED: similar to insulin-like growth...   237   4e-61
UniRef50_UPI0000E47549 PREDICTED: similar to Cek8 n=2 Tax=Strong...   236   8e-61
UniRef50_Q4T272 Chromosome undetermined SCAF10323, whole genome ...   235   1e-60
UniRef50_Q21764 Protein R05H5.4, partially confirmed by transcri...   235   1e-60
UniRef50_UPI0000DB6DD4 PREDICTED: similar to Insulin-like growth...   234   3e-60
UniRef50_B7QJ81 Eph receptor tyrosine kinase, putative n=1 Tax=I...   233   3e-60
UniRef50_Q4SUM3 Ephrin receptor (Fragment) n=5 Tax=Tetraodontida...   233   4e-60
UniRef50_Q93105 Insulin-like receptor beta chain n=1 Tax=Aedes a...   233   5e-60
UniRef50_Q4SP88 Ephrin receptor (Fragment) n=4 Tax=Euteleostomi ...   232   8e-60
UniRef50_A8WPD7 Putative uncharacterized protein n=4 Tax=Caenorh...   232   8e-60
UniRef50_Q19704 Protein F22B3.8, partially confirmed by transcri...   232   1e-59
UniRef50_Q9N3S5 Putative uncharacterized protein n=4 Tax=Caenorh...   232   1e-59
UniRef50_Q9Y1Y3 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   231   2e-59
UniRef50_P42687 Tyrosine-protein kinase SPK-1 n=1 Tax=Girardia t...   231   2e-59
UniRef50_A8QEG4 Protein kinase domain containing protein n=1 Tax...   231   3e-59
UniRef50_B3XVX8 Protein tyrosine kinase fes/fps n=1 Tax=Codonosi...   230   3e-59
UniRef50_O44570 Putative uncharacterized protein n=1 Tax=Caenorh...   230   5e-59
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...   229   8e-59
UniRef50_B3XVX1 Protein tyrosine kinase syk (Fragment) n=1 Tax=M...   229   8e-59
UniRef50_UPI000180C9B0 PREDICTED: ephrin receptor gamma n=1 Tax=...   228   1e-58
UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   228   1e-58
UniRef50_Q5D184 Ephrin receptor n=5 Tax=Neoptera RepID=Q5D184_APIME   228   2e-58
UniRef50_A8XT57 Putative uncharacterized protein n=1 Tax=Caenorh...   228   2e-58
UniRef50_B7QM19 Tyrosine-protein kinase receptor n=2 Tax=Ixodes ...   227   2e-58
UniRef50_C4PYF4 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   227   3e-58
UniRef50_Q25410 Putative molluscan insulin-related peptide(s) re...   227   3e-58
UniRef50_Q4H3M4 Ephrin receptor n=1 Tax=Ciona intestinalis RepID...   227   3e-58
UniRef50_A8P3F9 Protein kinase domain containing protein n=1 Tax...   227   4e-58
UniRef50_Q9V4E5 Eph receptor tyrosine kinase, isoform C n=25 Tax...   227   4e-58
UniRef50_Q4H3M7 Ephrin receptor n=3 Tax=Ciona RepID=Q4H3M7_CIOIN      226   5e-58
UniRef50_UPI00019252ED PREDICTED: similar to predicted protein n...   226   6e-58
UniRef50_A8XI09 Putative uncharacterized protein n=1 Tax=Caenorh...   226   6e-58
UniRef50_Q4SFJ9 Chromosome 7 SCAF14601, whole genome shotgun seq...   225   1e-57
UniRef50_Q98TD0 Ephrin receptor n=6 Tax=Amniota RepID=Q98TD0_CHICK    225   1e-57
UniRef50_UPI00017923B4 PREDICTED: similar to insulin receptor n=...   224   2e-57
UniRef50_UPI000186E0DC Insulin receptor precursor, putative n=2 ...   224   3e-57
UniRef50_Q9XXE5 Protein Y43C5B.2, partially confirmed by transcr...   224   3e-57
UniRef50_C5H7R9 Venus kinase receptor (Fragment) n=2 Tax=Triboli...   223   4e-57
UniRef50_B4LZ52 GJ23294 n=4 Tax=Coelomata RepID=B4LZ52_DROVI          223   5e-57
UniRef50_UPI0001925F5B PREDICTED: similar to ephrin receptor Eph...   222   9e-57
UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rer...   222   1e-56
UniRef50_B2WR86 Fibroblast growth factor receptor A n=3 Tax=Nema...   222   1e-56
UniRef50_P06213 Insulin receptor subunit beta n=70 Tax=Euteleost...   221   2e-56
UniRef50_Q9V6K3 Tyrosine-protein kinase transmembrane receptor R...   221   3e-56
UniRef50_C4QEV8 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   220   3e-56
UniRef50_Q05397 Focal adhesion kinase 1 n=105 Tax=cellular organ...   220   4e-56
UniRef50_Q7Q0F6 Tyrosine-protein kinase receptor n=1 Tax=Anophel...   220   4e-56
UniRef50_Q9U5A8 Tyrosine-protein kinase receptor n=4 Tax=Coeloma...   219   5e-56
UniRef50_UPI000155484B PREDICTED: similar to type 1 IGF receptor...   219   7e-56
UniRef50_Q4RXA0 Chromosome 11 SCAF14979, whole genome shotgun se...   219   7e-56
UniRef50_Q21292 Protein K07F5.4a, partially confirmed by transcr...   219   8e-56
UniRef50_C4XV92 Venus kinase receptor (Fragment) n=6 Tax=Drosoph...   219   9e-56
UniRef50_Q7YT64 Tyrosine-protein kinase receptor (Fragment) n=2 ...   219   9e-56
UniRef50_UPI00017B4565 UPI00017B4565 related cluster n=1 Tax=Tet...   219   1e-55
UniRef50_Q4S6E0 Chromosome 10 SCAF14728, whole genome shotgun se...   218   2e-55
UniRef50_Q16620 BDNF/NT-3 growth factors receptor n=90 Tax=Eutel...   217   2e-55
UniRef50_UPI0000EC9DFD Insulin receptor related tyrosine kinase ...   217   2e-55
UniRef50_B4JPQ9 GH13351 n=3 Tax=Drosophila RepID=B4JPQ9_DROGR         217   2e-55
UniRef50_P08069 Insulin-like growth factor 1 receptor beta chain...   217   3e-55
UniRef50_Q2EKC1 Fibroblast growth factor receptor n=3 Tax=Eumeta...   217   3e-55
UniRef50_UPI000180B037 PREDICTED: insulin receptor, partial n=1 ...   216   4e-55
UniRef50_C4XV89 Venus kinase receptor (Fragment) n=2 Tax=Pedicul...   216   4e-55
UniRef50_Q05688 Insulin-like growth factor 1 receptor beta chain...   216   5e-55
UniRef50_Q8IXC7 Isoform of FGFR2 n=10 Tax=Euteleostomi RepID=Q8I...   216   5e-55
UniRef50_P21802 Fibroblast growth factor receptor 2 n=316 Tax=Eu...   216   5e-55
UniRef50_B7Q0S4 Tyrosine-protein kinase receptor n=1 Tax=Ixodes ...   216   6e-55
UniRef50_Q4SMF1 Chromosome 8 SCAF14552, whole genome shotgun seq...   216   6e-55
UniRef50_Q17JW1 Tyrosine protein kinase n=2 Tax=Culicini RepID=Q...   216   6e-55
UniRef50_UPI0001A2C9CC UPI0001A2C9CC related cluster n=1 Tax=Dan...   216   6e-55
UniRef50_UPI0001926939 PREDICTED: similar to eph receptor A7 n=4...   216   7e-55
UniRef50_B8JIA2 Fibroblast growth factor receptor 3 (Fragment) n...   216   8e-55
UniRef50_C4XV88 Venus kinase receptor (Fragment) n=3 Tax=Coeloma...   216   8e-55
UniRef50_P14616 Insulin receptor-related protein beta chain n=11...   215   1e-54
UniRef50_P29322 Ephrin type-A receptor 8 n=37 Tax=Coelomata RepI...   215   1e-54
UniRef50_Q8JG38 Fibroblast growth factor receptor 2 n=25 Tax=Eut...   215   1e-54
UniRef50_Q0P4R9 Discoidin domain receptor family, member 2 n=5 T...   214   2e-54
UniRef50_C5H7S1 Venus kinase receptor n=3 Tax=Culicidae RepID=C5...   214   2e-54
UniRef50_P09208 Insulin-like receptor subunit beta 2 n=48 Tax=Co...   214   2e-54
UniRef50_C9DED1 Fibroblast growth factor receptor B n=1 Tax=Sacc...   214   2e-54
UniRef50_Q59FL9 Fibroblast growth factor receptor 3 isoform 1 va...   214   2e-54
UniRef50_Q4H3B8 Tyrosine-protein kinase receptor n=2 Tax=Ciona i...   214   2e-54
UniRef50_B0XH62 Fibroblast growth factor receptor 3 n=1 Tax=Cule...   214   2e-54
UniRef50_C5H7S0 Venus kinase receptor (Fragment) n=2 Tax=Apis me...   214   3e-54
UniRef50_A3KPS2 Tyrosine-protein kinase receptor (Fragment) n=11...   214   3e-54
UniRef50_Q2LC18 Tyrosine-protein kinase receptor (Fragment) n=2 ...   214   3e-54
UniRef50_UPI000186EA5D proto-oncogene receptor tyrosine protein ...   213   4e-54
UniRef50_UPI000175802D PREDICTED: similar to leukocyte receptor ...   213   5e-54
UniRef50_P07949 Proto-oncogene tyrosine-protein kinase receptor ...   213   5e-54
UniRef50_UPI00004D7E5F Proto-oncogene tyrosine-protein kinase ME...   213   5e-54
UniRef50_UPI0001923CA2 PREDICTED: similar to predicted protein n...   213   5e-54
UniRef50_C4Q5Z3 Ephrin receptor, putative n=1 Tax=Schistosoma ma...   213   5e-54
UniRef50_Q1JUB8 Fibroblast growth factor receptor n=3 Tax=Endopt...   213   6e-54
UniRef50_P00529 Tyrosine-protein kinase transforming protein ros...   212   7e-54
UniRef50_Q7QIP0 AGAP006988-PA n=5 Tax=Endopterygota RepID=Q7QIP0...   212   8e-54
UniRef50_Q4S1S8 Chromosome undetermined SCAF14764, whole genome ...   212   8e-54
UniRef50_C9DED0 Fibroblast growth factor receptor A n=2 Tax=Sacc...   212   8e-54
UniRef50_B3RWF6 Putative uncharacterized protein (Fragment) n=1 ...   212   9e-54
UniRef50_B2WR85 Fibroblast growth factor receptor B n=4 Tax=Nema...   212   1e-53
UniRef50_Q170Z1 Tyrosine-protein kinase receptor (Fragment) n=1 ...   211   1e-53
UniRef50_B0XJJ2 Testis-specific serine/threonine-protein kinase ...   211   2e-53
UniRef50_UPI0001792C07 PREDICTED: similar to tyrosine-protein ki...   211   2e-53
UniRef50_B0XJ86 Fibroblast growth factor receptor 1 n=1 Tax=Cule...   211   2e-53
UniRef50_UPI000186EE87 tyrosine kinase receptor, putative n=4 Ta...   211   2e-53
UniRef50_Q16832 Discoidin domain-containing receptor 2 n=50 Tax=...   211   2e-53
UniRef50_Q52V39 Tyrosine-protein kinase receptor n=3 Tax=Branchi...   211   2e-53
UniRef50_B4N8K5 GK12078 n=18 Tax=Metazoa RepID=B4N8K5_DROWI           211   2e-53
UniRef50_P21709 Ephrin type-A receptor 1 n=21 Tax=Mammalia RepID...   211   2e-53
UniRef50_UPI000180B27C PREDICTED: similar to proto-oncogene c-ro...   211   2e-53
UniRef50_B4DP99 cDNA FLJ51496, highly similar to Tyrosine-protei...   211   3e-53
UniRef50_A9VBG8 Predicted protein n=1 Tax=Monosiga brevicollis R...   211   3e-53
UniRef50_Q7KJ08 Alk n=7 Tax=melanogaster group RepID=Q7KJ08_DROME     211   3e-53
UniRef50_A9V127 Predicted protein n=2 Tax=Fungi/Metazoa group Re...   211   3e-53
UniRef50_B0XF28 Fibroblast growth factor receptor 2 n=1 Tax=Cule...   210   3e-53
UniRef50_D2H0P6 Tyrosine-protein kinase receptor (Fragment) n=5 ...   210   3e-53
UniRef50_Q28WN9 GA20930 n=6 Tax=Drosophila RepID=Q28WN9_DROPS         210   4e-53

Sequences not found previously or not previously below threshold:

UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...   245   1e-63

>UniRef50_Q18865 Putative uncharacterized protein n=6 Tax=Caenorhabditis
           RepID=Q18865_CAEEL
          Length = 431

 Score =  348 bits (893), Expect = 1e-94,   Method: Composition-based stats.
 Identities = 257/261 (98%), Positives = 258/261 (98%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEK TSANH
Sbjct: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKNTSANH 60

Query: 61  FVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           FVVRE+DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVK VLK AVERQKWELYHED
Sbjct: 61  FVVREADHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKVVLKHAVERQKWELYHED 120

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN
Sbjct: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIH 240
           LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIH
Sbjct: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIH 240

Query: 241 EKNLMHRDVAARNCLYGGGQV 261
           EKNLMHRDVAARNCLYGGGQV
Sbjct: 241 EKNLMHRDVAARNCLYGGGQV 261


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  334 bits (858), Expect = 2e-90,   Method: Composition-based stats.
 Identities = 78/272 (28%), Positives = 129/272 (47%), Gaps = 27/272 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G+     LS+    +    H+
Sbjct: 166 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQ-----LSISLRYEGRVYHY 220

Query: 62  VVRES-DHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE------RQK 113
            +  + D KVYV  +  F T+ ELV+H+ +  +   T          +           K
Sbjct: 221 RINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK 280

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV+ G   K        + VAVKT K ++M   +++E ++
Sbjct: 281 WEMERTDITMKHKLGGGQYGEVYVGVWKKY------SLTVAVKTLKEDTM---EVEEFLK 331

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIY 230
           EA +M+ + H N+V+  GV     P Y++ E    G L   L + +      +    +  
Sbjct: 332 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 391

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q ++ + Y+ +KN +HRD+AARNCL G   V+
Sbjct: 392 QISSAMEYLEKKNFIHRDLAARNCLVGENHVV 423


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  334 bits (857), Expect = 2e-90,   Method: Composition-based stats.
 Identities = 84/275 (30%), Positives = 136/275 (49%), Gaps = 31/275 (11%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
           D+ L  + ++ G + R D ++ L    NK G FL+R SE  KGE   F LSV+       
Sbjct: 108 DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGE---FSLSVL--DGAVV 162

Query: 59  NHFVVRESD-HKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ---- 112
            H+ ++  D    ++ +   F T+ E V+HY  T +    K G     ++          
Sbjct: 163 KHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYK 222

Query: 113 ---KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
              +WE+    ++L K+LG G FGEVW+G         +    VAVKT K  SM      
Sbjct: 223 TVDQWEIDRNSIQLLKRLGSGQFGEVWEGLW-------NNTTPVAVKTLKPGSMDPN--- 272

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKY 226
           + +REA++M+NL H  +++ + V    +P+Y+I EL   G+L   L         + ++ 
Sbjct: 273 DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQV 332

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
           ++  Q A+G+AY+  +N +HRD+AARN L G   +
Sbjct: 333 DMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNI 367


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score =  332 bits (853), Expect = 7e-90,   Method: Composition-based stats.
 Identities = 98/264 (37%), Positives = 150/264 (56%), Gaps = 17/264 (6%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           +++K L  Q +YHG +PR + QE+L K G FL+R S    GE   +VLSV  + +    H
Sbjct: 450 ISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGE---YVLSVYSDGQR--RH 504

Query: 61  FVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           F+++  D+    +  GF  I +L++H+ +TK+  + K G V  +L    + +KW L HED
Sbjct: 505 FIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVV--LLNPIPKDKKWILSHED 562

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V L + LG+G FGEV+KG L            VAVKT K + + +E   + ++EA++++ 
Sbjct: 563 VILGELLGKGNFGEVYKGTLKD-------KTSVAVKTCKED-LPQELKIKFLQEAKILKQ 614

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAY 238
            DH N+VK  GV    +P+Y+IMEL  GG   + L +      + +  +    AA G+ Y
Sbjct: 615 YDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLY 674

Query: 239 IHEKNLMHRDVAARNCLYGGGQVL 262
           +  KN +HRD+AARNCL G   VL
Sbjct: 675 LESKNCIHRDLAARNCLVGENNVL 698


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  329 bits (844), Expect = 6e-89,   Method: Composition-based stats.
 Identities = 75/273 (27%), Positives = 128/273 (46%), Gaps = 28/273 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 167 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 221

Query: 62  VVRE--SDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA------VERQ 112
            + E  SD KVYV  +  F T+ ELV+H+    +   T+         +        E  
Sbjct: 222 RINEDTSDGKVYVTTESRFNTLAELVHHHSMHSDGLITQLLYPAPKHNKPTVFALSPEPD 281

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WE+   D+ +  KLG G +G+V++    +        + VAVKT K ++M    +K+ +
Sbjct: 282 EWEINRTDIVMRHKLGGGQYGDVYEAVWKRYN------MTVAVKTLKEDTM---ALKDFL 332

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELI 229
            EA +M+ + H N+V+  GV     P Y+I E    G L   L    + +   +    + 
Sbjct: 333 EEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMSKGNLLDYLRQGNRENINAVVLMYMA 392

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            Q A+ ++Y+  +  +HRD+AARNCL G   ++
Sbjct: 393 TQIASAMSYLESRMFIHRDLAARNCLVGENHLV 425


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  328 bits (843), Expect = 9e-89,   Method: Composition-based stats.
 Identities = 79/274 (28%), Positives = 130/274 (47%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++    +S+  + +    H+
Sbjct: 190 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR---SISLRYDGR--VYHY 244

Query: 62  VVRE-SDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE--------R 111
            + E SD KVYV  +  F T+ ELV+H+    E        +    KQ            
Sbjct: 245 RISEDSDGKVYVTAEAKFNTLAELVHHHSVLHEGHGLITPLLYPAPKQNKPTVFPLSPEP 304

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ 
Sbjct: 305 DEWEICRTDIVMKHKLGGGQYGEVYEAVWKRYGN------TVAVKTLKEDTM---ALKDF 355

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYEL 228
           + EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +
Sbjct: 356 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYM 415

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+  +N +HRD+AARNCL G   ++
Sbjct: 416 ATQIASGMSYLESRNFIHRDLAARNCLVGDNNLV 449


>UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA
          Length = 1315

 Score =  328 bits (842), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 90/264 (34%), Positives = 153/264 (57%), Gaps = 17/264 (6%)

Query: 2    TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
            T++ L  ++++HG+LPRE++  +L   G FL+R  E  + ++ Q VLSV         HF
Sbjct: 942  TNRPLHEEEWFHGVLPREEVVRLLRNEGDFLVR--ETTRNDESQTVLSVCWNG---HKHF 996

Query: 62   VVRES-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
            +V+ + +     +   FP+I EL+ H   ++   + + G   AVL++ V R++WEL ++D
Sbjct: 997  IVQTTAEGHYRFEGPAFPSIQELIVHQYQSELPVTGRSG---AVLRKPVLRERWELSNDD 1053

Query: 121  VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
            V L  K+G G FG+V+K KL      + +  LVAVKT ++ ++ +EQ ++ ++E R+++ 
Sbjct: 1054 VILLDKIGRGNFGDVYKAKLK-----SSKNTLVAVKTCRM-TLPEEQKRKFLQEGRILKQ 1107

Query: 181  LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAY 238
             DH N+VK  G+    +P+ ++MEL  GG+L   L K        +   +   AA G+ Y
Sbjct: 1108 YDHPNIVKLIGICVQKQPIMIVMELVAGGSLLMFLRKNASTLGQRQMMGMCRDAAAGMRY 1167

Query: 239  IHEKNLMHRDVAARNCLYGGGQVL 262
            +  KN +HRD+AARNCL G   ++
Sbjct: 1168 LESKNCIHRDLAARNCLIGSENIV 1191


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score =  328 bits (841), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 76/272 (27%), Positives = 128/272 (47%), Gaps = 27/272 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 6   NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 60

Query: 62  VVRES-DHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQA------VERQK 113
            +  + D K+YV     F T+ ELV+H+ +  +   T          +           K
Sbjct: 61  RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK 120

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++G   K        + VAVKT K ++M   +++E ++
Sbjct: 121 WEMERTDITMKHKLGGGQYGEVYEGVWKKY------SLTVAVKTLKEDTM---EVEEFLK 171

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIY 230
           EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +  
Sbjct: 172 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMAT 231

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q ++ + Y+ +KN +HRD+AARNCL G   ++
Sbjct: 232 QISSAMEYLEKKNFIHRDLAARNCLVGENHLV 263


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  327 bits (839), Expect = 3e-88,   Method: Composition-based stats.
 Identities = 76/272 (27%), Positives = 129/272 (47%), Gaps = 27/272 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 120 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 174

Query: 62  VVRES-DHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQA------VERQK 113
            +  + D K+YV     F T+ ELV+H+ +  +   T          +           K
Sbjct: 175 RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK 234

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++G   K        + VAVKT K ++M   +++E ++
Sbjct: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKY------SLTVAVKTLKEDTM---EVEEFLK 285

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK---KYELIY 230
           EA +M+ + H N+V+  GV     P Y+I E    G L   L + +   +       +  
Sbjct: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q ++ + Y+ +KN +HRD+AARNCL G   ++
Sbjct: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLV 377


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  326 bits (836), Expect = 6e-88,   Method: Composition-based stats.
 Identities = 75/277 (27%), Positives = 128/277 (46%), Gaps = 33/277 (11%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           K +  + +Y   + R + ++ L    N+ G FL+R SE    +   + LSV      +  
Sbjct: 123 KSIEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHND---YSLSVR--DGDTVK 177

Query: 60  HFVVRESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA-------VE 110
           H+ +R+ D   +    +  F T+ ELV HY    +            +++          
Sbjct: 178 HYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRT 237

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
           R +WE+    ++  +KLG G FG+VW+G         +    VA+KT K  +M     K+
Sbjct: 238 RDQWEIDRTSLKFVRKLGSGQFGDVWEGLW-------NNTTPVAIKTLKSGTMDP---KD 287

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK-----LHFPMIKK 225
            + EA++M+ L H  +++ + V    EP+Y+I EL   G+L   L           M   
Sbjct: 288 FLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTL 347

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            ++  Q A G+AY+  +N +HRD+AARN L G G ++
Sbjct: 348 IDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIV 384


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  325 bits (834), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 72/274 (26%), Positives = 122/274 (44%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 255 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 309

Query: 62  VVRESDHK--VYVDKIGFPTIIELVNHYV--STKESFSTKDGTVKAVLKQA------VER 111
            + E          +  F T+ ELV+H+          T          +        E 
Sbjct: 310 RISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEP 369

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ 
Sbjct: 370 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGN------TVAVKTLKEDTM---ALKDF 420

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYEL 228
           + EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +
Sbjct: 421 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYM 480

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+  +N +HRD+AARNCL G  +++
Sbjct: 481 ATQIASGMSYLESRNYIHRDLAARNCLVGDNKLV 514


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  325 bits (834), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 72/274 (26%), Positives = 122/274 (44%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 246 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 300

Query: 62  VVRESDHK--VYVDKIGFPTIIELVNHYV--STKESFSTKDGTVKAVLKQA------VER 111
            + E          +  F T+ ELV+H+          T          +        E 
Sbjct: 301 RISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEP 360

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ 
Sbjct: 361 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGN------TVAVKTLKEDTM---ALKDF 411

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYEL 228
           + EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +
Sbjct: 412 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYM 471

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+  +N +HRD+AARNCL G  +++
Sbjct: 472 ATQIASGMSYLESRNYIHRDLAARNCLVGDNKLV 505


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  325 bits (834), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 72/274 (26%), Positives = 122/274 (44%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++     S+    +    H+
Sbjct: 247 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR-----SISLRYEGRVYHY 301

Query: 62  VVRESDHK--VYVDKIGFPTIIELVNHYV--STKESFSTKDGTVKAVLKQA------VER 111
            + E          +  F T+ ELV+H+          T          +        E 
Sbjct: 302 RISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEP 361

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ 
Sbjct: 362 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGN------TVAVKTLKEDTM---ALKDF 412

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYEL 228
           + EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +
Sbjct: 413 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYM 472

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+  +N +HRD+AARNCL G  +++
Sbjct: 473 ATQIASGMSYLESRNYIHRDLAARNCLVGDNKLV 506


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score =  324 bits (832), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 80/272 (29%), Positives = 130/272 (47%), Gaps = 27/272 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G +    +S+  + +    H+
Sbjct: 180 NSLEKHSWYHGPISRNAAEYLLSSGIDGSFLVRDSESSPGHR---SISLRFDGR--VYHY 234

Query: 62  VVRE-SDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA------VERQK 113
            +   SD KV+V  +  F TI ELV+H+    +   T      A +++           +
Sbjct: 235 RISSGSDGKVFVTTESKFSTIAELVHHHCKQSDGLITTLRYPAAKMQKPIIYGVSPLPDE 294

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   D+ +  KLG G +GEV++    K          VAVKT + E+M   ++ E +R
Sbjct: 295 WEIERTDISMKNKLGGGQYGEVYEAIWKKHNKI------VAVKTLREENM---RVDEFLR 345

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKYELIY 230
           EA +M+N+ H N+V+  GV     P Y++ E    G L   L        P +    +  
Sbjct: 346 EAAVMKNVKHPNLVQLLGVCTREPPFYIVTEFMPYGNLLEYLRDNDETSLPAVTLLYMAT 405

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q A G++Y+ + + +HRD+AARNCL G   +L
Sbjct: 406 QVAFGMSYLEKNSFIHRDLAARNCLLGEHHLL 437


>UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateria RepID=FPS_DROME
          Length = 1325

 Score =  321 bits (825), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 88/259 (33%), Positives = 150/259 (57%), Gaps = 18/259 (6%)

Query: 2    TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
            T++ L  ++++HG+LPRE++  +LN  G FL+R  E ++ E+ Q VLSV         HF
Sbjct: 951  TNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVR--ETIRNEESQIVLSVCWNG---HKHF 1005

Query: 62   VVRESDHK-VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
            +V+ +       +   F +I EL+ H   ++   + K G   A+L++ V R++WEL ++D
Sbjct: 1006 IVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSG---AILRRPVCRERWELSNDD 1062

Query: 121  VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
            V L +++G G FG+V+K KL          + VAVKT ++ ++  EQ ++ ++E R+++ 
Sbjct: 1063 VVLLERIGRGNFGDVYKAKLK------STKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQ 1115

Query: 181  LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAY 238
             DH N+VK  G+    +P+ ++MEL  GG+L + L K        ++  +   AA G+ Y
Sbjct: 1116 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRY 1175

Query: 239  IHEKNLMHRDVAARNCLYG 257
            +  KN +HRD+AARNCL  
Sbjct: 1176 LESKNCIHRDLAARNCLVD 1194


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  320 bits (822), Expect = 3e-86,   Method: Composition-based stats.
 Identities = 80/274 (29%), Positives = 130/274 (47%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQ----FLLRTSEPVKGEKRQFVLSVVGEKK---T 56
             +  +++Y G + R+D + +L  PG     FL+R SE  KG    + LS+    +    
Sbjct: 151 DSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGA---YSLSIRDWDEIRGD 207

Query: 57  SANHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE---R 111
           +  H+ +R+ D+  Y    +  F T+ +LV HY    +    K  TV   +K   +   +
Sbjct: 208 NVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAK 267

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             WE+  E + L  KLG+G FGEVW G              VA+KT K  +M  E     
Sbjct: 268 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-------TTKVAIKTLKPGTMMPEA---F 317

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYEL 228
           ++EA++M+ L H  +V  + V +  EP+Y++ E    G+L   L +       + +  ++
Sbjct: 318 LQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDM 376

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G+AYI   N +HRD+ A N L G   V 
Sbjct: 377 AAQIADGMAYIERMNYIHRDLRAANILVGENLVC 410


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  320 bits (821), Expect = 3e-86,   Method: Composition-based stats.
 Identities = 77/272 (28%), Positives = 126/272 (46%), Gaps = 27/272 (9%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLN----KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
           +K    +++Y G + R + ++ L       G FL+R +E   G    F LSV      S 
Sbjct: 118 EKSYEAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVG---NFSLSVR--DGDSV 172

Query: 59  NHFVVRESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ---AVERQK 113
            H+ VR+ D   Y    +  F ++ ELV HY    +             K     + +  
Sbjct: 173 KHYRVRKLDTGGYFITTRAPFNSLYELVQHYTKDADGLVCALTLPCPKDKPVTGGIAKDA 232

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+  E + L +KLG G FGEVW G         +    VAVKT K  +M+       + 
Sbjct: 233 WEIPRESLRLNRKLGAGQFGEVWAGVW-------NNTTQVAVKTLKPGTMSPA---SFLD 282

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKYELIY 230
           EA +M+ L H ++V+ + + +  EP+Y++ E   GG+L   L K    +  +    ++  
Sbjct: 283 EAGVMKKLRHKHLVQLYAICSDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAA 342

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q A+G+A++  +  +HRD+AARN L G   + 
Sbjct: 343 QVASGMAFLEAQGYIHRDLAARNILVGENYIC 374


>UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, partial n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793081
          Length = 770

 Score =  318 bits (815), Expect = 1e-85,   Method: Composition-based stats.
 Identities = 87/256 (33%), Positives = 148/256 (57%), Gaps = 18/256 (7%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           K L+ ++++HG+LPRE++  +L K G FL+R  E  + ++ Q VLSV         HF+V
Sbjct: 530 KSLIEEEWFHGVLPREEVVRLLTKEGDFLVR--ETTRNDENQTVLSVCWGG---HKHFIV 584

Query: 64  RES-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           + + + +   +   FPTI EL+ +   +    +++ G   A+L+Q + R++WEL ++DV 
Sbjct: 585 QTTSEGEFRFEGPSFPTIQELITYQYQSALPVTSRSG---AILRQPIPRERWELNNDDVL 641

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L +K+G G FG+V+K +L             AVKT ++ ++  E  K+ ++E R+++  D
Sbjct: 642 LLEKIGRGNFGDVYKARLRSTNKEA------AVKTCRV-TVPDEHKKKFLQEGRILKQYD 694

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIH 240
           H NVVK  G+    +P+ ++MEL  GG+L S L        +++   +   AA G+ Y+ 
Sbjct: 695 HPNVVKLIGICVQKQPIMIVMELVAGGSLLSYLRNNSKTLSVLQLVSMCRDAAAGMMYLE 754

Query: 241 EKNLMHRDVAARNCLY 256
            KN +HRD+AARNCL 
Sbjct: 755 SKNCIHRDLAARNCLV 770


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  318 bits (815), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 78/274 (28%), Positives = 137/274 (50%), Gaps = 30/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           K L  ++++ G + R + ++MLN+     G FL+R SE   G+   F LSV  + +    
Sbjct: 115 KSLDAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGD---FSLSV--KDQDRVR 169

Query: 60  HFVVRES-DHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAV-------E 110
           H+ VR   D  ++V +   F  + ELV+HY    +    K        ++          
Sbjct: 170 HYRVRRLEDGSLFVTRRSTFQILHELVDHYKIETDGLCCKLLYPCLQAEKPQTAGLLRQA 229

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
            ++WE+    ++L ++LG G FGEVW+G              VAVKT K  +M+   ++E
Sbjct: 230 NEEWEIEKTQIKLLRRLGAGQFGEVWEGLWNG-------TTSVAVKTLKPGTMS---VEE 279

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYEL 228
            ++EA +M+ L H  +++ + V    EP+Y++ EL   G+L   L        + +  ++
Sbjct: 280 FLQEASIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQLVDV 339

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+ ++N +HRD+AARN L G   + 
Sbjct: 340 AAQVASGMSYLEQQNYIHRDLAARNILVGEHGIC 373


>UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7PSP3_IXOSC
          Length = 674

 Score =  317 bits (814), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 87/260 (33%), Positives = 146/260 (56%), Gaps = 18/260 (6%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           L  + ++HG+LPRE++  +L   G +L+R  E ++ E++Q VLSV  +      HF+V+ 
Sbjct: 308 LQDEDWFHGVLPREEVVRLLVNNGDYLVR--ETMRNEEKQVVLSVCWQG---HKHFIVQT 362

Query: 66  S-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT 124
           + D K   +   F T+ EL+ +        ++K G   A+L+  + R++WEL ++DVEL 
Sbjct: 363 TSDGKYRFEGPAFGTVQELIVYQHHLGLPVTSKSG---AILQNPIFRERWELNNDDVELV 419

Query: 125 KKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHI 184
           +K+G G FG+V++  L        Q   VAVKT ++  +  E  K+ ++E R+++  DH 
Sbjct: 420 EKIGRGNFGDVYRAVLHP------QRTEVAVKTCRVN-LPDEHKKKFLQEGRILKQYDHP 472

Query: 185 NVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEK 242
           N+VKF G+    +P+ ++MEL  GG+L + L          +   +    A G+AY+  K
Sbjct: 473 NIVKFIGICVQKQPIMIVMELVPGGSLLAFLRNQGPKLNPKELLNMCIDTAAGMAYLESK 532

Query: 243 NLMHRDVAARNCLYGGGQVL 262
           N +HRD+AARNCL G    +
Sbjct: 533 NCIHRDLAARNCLVGRNNTV 552


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score =  317 bits (814), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 74/276 (26%), Positives = 119/276 (43%), Gaps = 28/276 (10%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
           +    L  +K+YHG + R   + +LN    G FL+R SE   G   Q  +S+  E +   
Sbjct: 157 LARVGLESEKWYHGAIQRSYAEYLLNSGITGSFLIRESESHPG---QLTISLRYEGQIW- 212

Query: 59  NHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAV-------LKQAV 109
            H+ +   D  +Y  ++   F ++ +LV+H+    +  +                L+   
Sbjct: 213 -HYRIHRDDSNMYYVIESNKFTSVSDLVHHHEKHSDGLACTLLYPAPKRDRTSSELRMDP 271

Query: 110 ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
                E+   ++ +  KLG G +G V++             VLVAVKT K     ++   
Sbjct: 272 SFDIREIDRTEIVMKHKLGSGQYGVVYEAVWKPYN------VLVAVKTLKENVTVRD--- 322

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKY 226
           E + EARLM++L H N+V   G      P Y++ E    G L   L              
Sbjct: 323 EFLEEARLMKSLRHPNLVTLLGACTREPPYYIVTEFMCNGNLLDYLRTHPRTELTPSVLL 382

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            +  Q A G+AY+ + N +HRD+AARNCL G    +
Sbjct: 383 HMATQVARGMAYLEQHNFIHRDLAARNCLVGTQHTI 418


>UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=4 Tax=Endopterygota
           RepID=P18106-3
          Length = 475

 Score =  317 bits (813), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 88/259 (33%), Positives = 150/259 (57%), Gaps = 18/259 (6%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           T++ L  ++++HG+LPRE++  +LN  G FL+R  E ++ E+ Q VLSV         HF
Sbjct: 101 TNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVR--ETIRNEESQIVLSVCWNG---HKHF 155

Query: 62  VVRESDHK-VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           +V+ +       +   F +I EL+ H   ++   + K G   A+L++ V R++WEL ++D
Sbjct: 156 IVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSG---AILRRPVCRERWELSNDD 212

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V L +++G G FG+V+K KL          + VAVKT ++ ++  EQ ++ ++E R+++ 
Sbjct: 213 VVLLERIGRGNFGDVYKAKLK------STKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQ 265

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAY 238
            DH N+VK  G+    +P+ ++MEL  GG+L + L K        ++  +   AA G+ Y
Sbjct: 266 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRY 325

Query: 239 IHEKNLMHRDVAARNCLYG 257
           +  KN +HRD+AARNCL  
Sbjct: 326 LESKNCIHRDLAARNCLVD 344


>UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorhabditis briggsae
           RepID=A8XFT2_CAEBR
          Length = 577

 Score =  317 bits (813), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 155/266 (58%), Positives = 194/266 (72%), Gaps = 13/266 (4%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS--- 57
           M DKD+  + +YHGLLPREDI+ ML K G FL+R++EP +GE RQ+VLS +  ++     
Sbjct: 1   MFDKDIHTEPWYHGLLPREDIKAMLRKTGDFLIRSTEPKQGEARQYVLSAMQNEELEDAG 60

Query: 58  ANHFVVR-ESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL 116
             H+V+R  ++++++++  GF TI  LVN+Y++TK+           VLK  + +Q WE+
Sbjct: 61  VKHYVMRVNANNQIFLETKGFETITSLVNYYMTTKDPIKKMT-----VLKTPIVKQDWEI 115

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
            H  VELTKKLGEGAFGEVWKGK   I   N +    A+KTAKLES+ KEQIKEIMREAR
Sbjct: 116 EHSQVELTKKLGEGAFGEVWKGK---ITMKNGKVEDCAIKTAKLESLNKEQIKEIMREAR 172

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANG 235
           LMRNLDH NVVKFFGV AG EPLYVIMELAD GALDS L K  + P  KK E+IYQAA G
Sbjct: 173 LMRNLDHPNVVKFFGVGAGQEPLYVIMELADCGALDSYLQKNTNLPPAKKMEMIYQAACG 232

Query: 236 LAYIHEKNLMHRDVAARNCLYGGGQV 261
           + Y+HE+ L+HRD+AARNCLYGGGQV
Sbjct: 233 IGYMHERKLLHRDIAARNCLYGGGQV 258


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  315 bits (808), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 71/267 (26%), Positives = 120/267 (44%), Gaps = 29/267 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R   + +L+    G FL+R SE   G++    +S+  + +    H+
Sbjct: 266 NSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR---SISLRYDGR--VYHY 320

Query: 62  VVRESDHK--VYVDKIGFPTIIELVNHYV--STKESFSTKDGTVKAVLKQA------VER 111
            + E          +  F T+ ELV+H+          T          +        E 
Sbjct: 321 RISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEP 380

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WE+   D+ +  KLG G +GEV++    +  +       VAVKT K ++M    +K+ 
Sbjct: 381 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGN------TVAVKTLKEDTM---ALKDF 431

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYEL 228
           + EA +M+ + H N+V+  GV     P Y+I E    G L   L    +     +    +
Sbjct: 432 LEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYM 491

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCL 255
             Q A+G++Y+  +N +HRD+AARNCL
Sbjct: 492 ATQIASGMSYLESRNYIHRDLAARNCL 518


>UniRef50_C4Q4A1 Term=tyrosine kinase
           5;db_xref=PMID:11289068;with=UniProt:Q9NH62;evidence=tra
           cea ble author statement n=2 Tax=Schistosoma mansoni
           RepID=C4Q4A1_SCHMA
          Length = 653

 Score =  314 bits (805), Expect = 2e-84,   Method: Composition-based stats.
 Identities = 79/279 (28%), Positives = 132/279 (47%), Gaps = 35/279 (12%)

Query: 5   DLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKK----- 55
            +  ++++  +L R+D + +L    N  G FL+R SE  +G      LSV  E++     
Sbjct: 173 SVEAEEWFMPMLSRKDSERLLLLEGNAQGVFLVRESETSQG---SLTLSVRDEERGLSGI 229

Query: 56  -TSANHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE-- 110
             +  H+ ++  D++ Y    K  F ++ EL+  Y         K               
Sbjct: 230 MNTVKHYRIKHPDYRYYYITTKCSFSSLQELIQFYSIDSHGLCCKLTRACLCPPPITSDL 289

Query: 111 ----RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKE 166
               +  WE+    + L +KLG G FGEVWKG              VAVKT K  +MTKE
Sbjct: 290 SVKTKDHWEISKSSIVLIEKLGAGQFGEVWKGTWNG-------TTEVAVKTLKQGTMTKE 342

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMI 223
              + ++EAR+MR   H  +V+ + V    +P+Y++ EL   G+L   L      +  + 
Sbjct: 343 ---DFLKEARIMRAAQHPKLVRLYAVCT-EDPIYIVTELMCNGSLLQYLRDGPGKNLLIN 398

Query: 224 KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +  +++ Q ANG+AY+ +++ +HRD+AARN L G    +
Sbjct: 399 QLVDMMAQIANGMAYLEKEHYIHRDLAARNILVGENNCV 437


>UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria RepID=Q2VXS8_HUMAN
          Length = 764

 Score =  313 bits (804), Expect = 3e-84,   Method: Composition-based stats.
 Identities = 90/261 (34%), Positives = 149/261 (57%), Gaps = 18/261 (6%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           K L  Q +YHG +PR ++ E+L   G FL+R S+     K+++VLSV+ +      HF++
Sbjct: 395 KPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQG----KQEYVLSVLWDG--LPRHFII 448

Query: 64  RESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
           +  D+   ++  GFP+I  L++H +ST++  + K G    VL +AV + KW L HED+ L
Sbjct: 449 QSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSG---VVLHRAVPKDKWVLNHEDLVL 505

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
            +++G G FGEV+ G+L           LVAVK+ + E++  +   + ++EAR+++   H
Sbjct: 506 GEQIGRGNFGEVFSGRLRA------DNTLVAVKSCR-ETLPPDLKAKFLQEARILKQYSH 558

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHE 241
            N+V+  GV    +P+Y++MEL  GG   + L        +    +++  AA G+ Y+  
Sbjct: 559 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 618

Query: 242 KNLMHRDVAARNCLYGGGQVL 262
           K  +HRD+AARNCL     VL
Sbjct: 619 KCCIHRDLAARNCLVTEKNVL 639


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  313 bits (804), Expect = 3e-84,   Method: Composition-based stats.
 Identities = 71/274 (25%), Positives = 125/274 (45%), Gaps = 29/274 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L    +YHG + R D + +L     G FL+R SE   G   Q+ +SV  + +    H+
Sbjct: 187 NSLDKYTWYHGKISRSDSEAILGSGITGSFLVRESETSIG---QYTISVRHDGR--VFHY 241

Query: 62  VVR--ESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ--------AVER 111
            +    ++      ++ F T+ ELV+H+    +          +   +            
Sbjct: 242 RINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRGLFSLSPNAP 301

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WEL   ++ +  KLG G +G+V++G   +          +AVK  K ++M    + E 
Sbjct: 302 DEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHD------CTIAVKALKEDAMP---LHEF 352

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYEL 228
           + EA +M++L H N+V+  GV     P Y+I E    G L   L +      P I   ++
Sbjct: 353 LAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQM 412

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++Y+  ++ +HRD+AARNCL     ++
Sbjct: 413 ASQIASGMSYLEARHFIHRDLAARNCLVSEHNIV 446


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score =  313 bits (804), Expect = 3e-84,   Method: Composition-based stats.
 Identities = 71/268 (26%), Positives = 117/268 (43%), Gaps = 27/268 (10%)

Query: 7   LHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
             + +Y G + R + Q  L   N  G FL+R SE   G    + LSV    +    ++ +
Sbjct: 254 ESEPWYVGKMSRVEAQSKLQIFNLDGTFLVRESETSAG---SYTLSVYFNGQP--RNYRI 308

Query: 64  RESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ----KWELYH 118
           +   ++ Y+  +    TI EL++++        T+        +          KWE+  
Sbjct: 309 QHDGNEYYITTRHRQKTIKELIDYHKLNGGGLCTRLKKPACDDEAPTPHDLGSDKWEIDP 368

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
            ++ L K LG G FG V+KGK   +         VAVK  K  +M ++   E + EA +M
Sbjct: 369 SEISLGKVLGSGQFGVVYKGKFQGV-------TDVAVKKVKGGAMAED---EFIAEAEIM 418

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI----KKYELIYQAAN 234
           +   H N+V  +GV     PL ++ E    G L + L   +  +         +  Q AN
Sbjct: 419 KQFKHKNLVNLYGVVTKKRPLMIVTEFMRNGCLLNYLRDHNSELQGRAPVLLYMSIQVAN 478

Query: 235 GLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + ++ E   +HRD+AARNCL G    +
Sbjct: 479 AMVFLEEHGFIHRDLAARNCLVGEHYAV 506


>UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepID=Q8T6F8_CAEEL
          Length = 533

 Score =  312 bits (801), Expect = 7e-84,   Method: Composition-based stats.
 Identities = 79/274 (28%), Positives = 129/274 (47%), Gaps = 32/274 (11%)

Query: 5   DLLHQKYYHGLLPREDIQEM-LNKP---GQFLLRTSEPVKGEKRQFVLSVVG----EKKT 56
            +  +++Y G +PR   + + L+     G FL+R  E    + R+F L++          
Sbjct: 132 TIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIRERE---ADTREFALTIRDTDDQRNGG 188

Query: 57  SANHFVVRESDH--KVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE--- 110
           +  H+ ++  DH    ++  +  F ++ ELV +Y    +    +       L        
Sbjct: 189 TVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLS 248

Query: 111 ---RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
              +Q WE+    + L +KLG+G FGEVW GK   I       V VA+KT K  +M+ E 
Sbjct: 249 HDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGI-------VEVAIKTMKPGTMSPEA 301

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKK 225
               ++EA++M+  DH N+VK + V    EP Y+I E    G+L   L        +   
Sbjct: 302 ---FLQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQAL 358

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
            ++  Q ANG+ Y+ E+ L+HRD+AARN L G  
Sbjct: 359 VDMAAQIANGMMYLEERKLVHRDLAARNVLVGDK 392


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score =  311 bits (799), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 73/269 (27%), Positives = 123/269 (45%), Gaps = 24/269 (8%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             L  + YYHG +PR   +  L+    G FL+R S+   GE     +S+  + K    H+
Sbjct: 172 NSLDSEPYYHGRIPRTTAEFFLSNGINGSFLVRESQSNAGEH---TISLRCDGK--VFHY 226

Query: 62  VVRESDHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQ---AVERQKWELY 117
            +  +D  V++     F T+ +LV  Y    +             +Q   A    KWE+ 
Sbjct: 227 RISRTDKGVFIAADRVFSTVQDLVKFYHQQSDGLVHPLRHAVPKNRQEITASPSDKWEID 286

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
              + +  +LG G +GEV++  L       ++   VAVKT K E+M   + K+ ++EA +
Sbjct: 287 RSSIMMGTRLGAGQYGEVYEAVLT------NKNRHVAVKTLKEEAM---EAKDFLKEAEV 337

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG----KLHFPMIKKYELIYQAA 233
           M+ L H N+V+  GV     PLY++ E    G L   +     +          +  Q +
Sbjct: 338 MKKLKHPNLVELIGVCTLESPLYIVTEYMCNGCLLDYIRDPIKQKEITPTAMMYIAEQIS 397

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            G+ ++  +N +HRD+AARNCL     ++
Sbjct: 398 AGMEFLESQNFIHRDLAARNCLVADNLLV 426


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score =  311 bits (799), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 68/271 (25%), Positives = 129/271 (47%), Gaps = 28/271 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGE-KKTSANHF 61
           L   ++Y G + R+  + +L    K G F++R S      K  + LS+  +  ++   H+
Sbjct: 405 LERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST----KGLYTLSLHTKVPQSHVKHY 460

Query: 62  VVRESD--HKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAV----ERQKWE 115
            ++++        +K    TI +L+N++       + +  +                KWE
Sbjct: 461 HIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWE 520

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           ++  ++ L ++LG G FG V +GK    +D        AVK  K  +M+++   + + EA
Sbjct: 521 IHPMELMLMEELGSGQFGVVRRGKWRGSIDT-------AVKMMKEGTMSED---DFIEEA 570

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI----KKYELIYQ 231
           ++M  L H N+V+ +GV +   P+Y++ E    G+L + L +    +I       ++  Q
Sbjct: 571 KVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQ 630

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + G+ Y+   N +HRD+AARNCL G   V+
Sbjct: 631 VSKGMTYLERHNYIHRDLAARNCLVGSENVV 661


>UniRef50_Q18684 Protein T13H10.1, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q18684_CAEEL
          Length = 533

 Score =  310 bits (796), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 131/261 (50%), Positives = 174/261 (66%), Gaps = 9/261 (3%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           ++ L  + +YHGLLPRED++++L + G FL+R ++P  GE R+FVLSV         H+V
Sbjct: 8   EQVLAKEPWYHGLLPREDMKQLLTQRGDFLVRFTDPKVGEPRKFVLSVYVGVIEDIRHYV 67

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           +RE ++K  VDK  F +I +L+N+Y  +KE  +   G  + V+ + + R+ WE  H DV 
Sbjct: 68  IREHNNKFAVDKKWFSSIADLLNYYHRSKEPVA---GGPETVIIRPIGREPWEKQHSDVT 124

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L KKLGEGAFGEV  G++       +     A+K AKLES+TKEQIKEIM EARLMR   
Sbjct: 125 LIKKLGEGAFGEVQLGEIR----IGNTVKKAAIKLAKLESLTKEQIKEIMHEARLMRKFK 180

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIH 240
           H NVV F+GVAAG EPL VIMELAD GALDS L K     P+ KK+ ++ QA  GL Y+H
Sbjct: 181 HPNVVTFYGVAAGQEPLMVIMELADNGALDSYLKKNIGSLPISKKHTMVLQAGLGLEYLH 240

Query: 241 EKNLMHRDVAARNCLYGGGQV 261
              ++HRD+A+RNCLYG GQV
Sbjct: 241 SLQIIHRDIASRNCLYGNGQV 261


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score =  310 bits (794), Expect = 4e-83,   Method: Composition-based stats.
 Identities = 76/287 (26%), Positives = 128/287 (44%), Gaps = 43/287 (14%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           K L  + ++ G + R   +++L     K G FL+R SE   G    F LS+  +   +  
Sbjct: 334 KSLEAEPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPG---TFSLSM--KDGENVR 388

Query: 60  HFVVRESDHKVYVDKIG---FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE-----R 111
           HF V++    + +          +  L+ ++   +   +T          +A +     +
Sbjct: 389 HFRVKKVAGGIKLQGSPSSPHKDLPSLIKYHKRHRGGLTTTLKVPCPREIRAPDIGYAVK 448

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            KWE+  + + L K+LGEG +GEV+KG+             VA+KT K  + + E   E 
Sbjct: 449 DKWEVDRDTIVLEKQLGEGQYGEVYKGRWNG-------TTEVAIKTLKSAATSAE---EF 498

Query: 172 MREARLMR-------------NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK- 217
           ++EA+LM+              L H N+VK   V    EP+++I EL   G+L   L   
Sbjct: 499 LQEAQLMKVRARVGIALARARKLQHDNLVKLHAVCTIGEPIFIITELCKFGSLLDYLRSP 558

Query: 218 --LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                 +    ++    A+G+AY+ E N +HRD+AARN L G   + 
Sbjct: 559 AGESLRLPTLIDMASDVAHGMAYLEENNYIHRDLAARNILVGENNIC 605


>UniRef50_UPI000186DA97 tyrosine-protein kinase transforming protein FPS, putative n=1
           Tax=Pediculus humanus corporis RepID=UPI000186DA97
          Length = 850

 Score =  310 bits (794), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 84/262 (32%), Positives = 147/262 (56%), Gaps = 18/262 (6%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           K L+ ++++HG+LPRE++  +L   G FL+R  E  + ++ Q VLSV         HF+V
Sbjct: 479 KALIDEEWFHGVLPREEVVRLLRHEGDFLVR--ETTRNDECQTVLSVAWGG---HKHFIV 533

Query: 64  RES-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           + + +     +   FPTI EL+ +   +    +++ G   A+LK+ + R+ WEL ++DV+
Sbjct: 534 QTNLEGHFRFEGPSFPTIQELILYQYQSGLPVTSRSG---AILKKPILREVWELNNDDVQ 590

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L  K+G G FG+V+K KL            VAVKT ++ ++  E  ++ ++E R+++  D
Sbjct: 591 LLDKIGRGNFGDVYKAKLKSTNQ------EVAVKTCRV-ALPDENKRKFLQEGRILKQYD 643

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIH 240
           H N+VK  G+    +P+ ++MEL  GG+L + L             ++    A+G+ Y+ 
Sbjct: 644 HPNIVKLIGICVQKQPIMIVMELVPGGSLLTFLRNNASTLTQKLLLKMCRDTASGMQYLE 703

Query: 241 EKNLMHRDVAARNCLYGGGQVL 262
            +N +HRD+AARNCL G   ++
Sbjct: 704 SRNCIHRDLAARNCLIGYENMV 725


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score =  309 bits (793), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 68/268 (25%), Positives = 118/268 (44%), Gaps = 26/268 (9%)

Query: 6   LLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           L  + ++ G + R +   ML    + G FL+R SE   GE   + LS+         H+ 
Sbjct: 340 LEGEPWFRGRISRAEAAAMLQITKQEGCFLVRESETQPGE---YTLSLSHN--EGVRHYR 394

Query: 63  VRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE----RQKWELY 117
           ++  + + +V +   F +I +L+ ++        T+           +        WEL 
Sbjct: 395 IQHIEGQYFVNENHRFDSIPQLIEYHKLNGGGIVTRLRRAINDANAPISVGLGHDMWELS 454

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
            ++ EL ++LG G FG V + +             VA+K  K   M+ +   + + EA +
Sbjct: 455 RDEFELGRELGSGQFGIVQQARYRNGQA-------VAIKMMKEGKMSAD---DFISEAVV 504

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKYELIYQAAN 234
           MR+L H ++V+  GV     PL++I EL   G L + L             + +    A+
Sbjct: 505 MRDLSHPHLVQLLGVCTKGGPLWIITELMSKGCLLNYLRDHKELRGEPQILHMMCVHIAS 564

Query: 235 GLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + Y+  K  +HRD+AARNCL G   V+
Sbjct: 565 AMEYLESKGFIHRDLAARNCLLGDNYVV 592


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score =  309 bits (793), Expect = 6e-83,   Method: Composition-based stats.
 Identities = 73/278 (26%), Positives = 127/278 (45%), Gaps = 32/278 (11%)

Query: 5   DLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQ-FVLSVVGEKKTSAN 59
            L  + +Y G + R D +++L    ++ G FL+R SE   G+    F LSV    K    
Sbjct: 123 TLEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSVR--DKELIR 180

Query: 60  HFVVRESDHKVYVDKIG--FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER------ 111
           H+ ++ +D   Y   +   F T+ EL+  Y  + +    K       +    ++      
Sbjct: 181 HYRIKITDSGKYFISLSKEFSTLNELIEFYKISSDGLKIKLLEPCRKVCIMFKKQVQTFG 240

Query: 112 ----QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
                KWE+  + +E   ++G G FG+V+KG         +  + VA+K+ K   M K+Q
Sbjct: 241 LSHKDKWEISRDSLEFQSRVGSGQFGDVYKGVW-------NSKIPVAIKSLKPGYMDKKQ 293

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIK 224
               + EA LM+ L H  +V+ + V    EPL ++ E    G+L   L           +
Sbjct: 294 ---FLAEANLMKQLRHPKLVQLYAVVTIEEPLLIVTEFMSNGSLLEFLRHNESKKLLFKE 350

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             ++  + A G+A++  K+ +HRD+AARN L G   ++
Sbjct: 351 LIDICAEVAQGMAFLELKSFIHRDLAARNILVGEHNLV 388


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score =  309 bits (792), Expect = 7e-83,   Method: Composition-based stats.
 Identities = 78/270 (28%), Positives = 124/270 (45%), Gaps = 21/270 (7%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
             +  +++++  + R+D +  L    NKPG +L+R SE  KG     +  V  + +    
Sbjct: 120 DTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVVK 179

Query: 60  HFVVRESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLK--QAVERQKWE 115
           H+ +R  D+  Y    KI F  I  ++ HY    +    K        K  +  ++  WE
Sbjct: 180 HYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKAQKPWDKDAWE 239

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +  + +++ KKLG G FGEVW           +    VAVKT K  +M+ E     + EA
Sbjct: 240 ISKDSIKMVKKLGAGQFGEVWMAFY-------NNSTKVAVKTLKPGTMSVEA---FLEEA 289

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKYELIYQA 232
            LM+ L H  +V+ + V   TEP+Y+I E    G+L   L         + K  +   Q 
Sbjct: 290 NLMKTLQHDRLVRLYAVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSAQI 349

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           A G+AYI +KN +HRD+ A N L     + 
Sbjct: 350 AEGMAYIEKKNYIHRDLRAANVLVSEMLLC 379


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score =  308 bits (791), Expect = 9e-83,   Method: Composition-based stats.
 Identities = 66/271 (24%), Positives = 123/271 (45%), Gaps = 27/271 (9%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
            L    +YHG + R   + +L+    G FL+R SE  +G      LSV      S  H+ 
Sbjct: 81  SLNMHTWYHGAVSRAAAEYLLSSGINGSFLVRDSESCRGH-----LSVSVRFNASVYHYR 135

Query: 63  VR-ESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA------VERQKW 114
           +  ++    Y+  +  F T+ ELV+H+    +  +       A   +        +  +W
Sbjct: 136 INVDTAGLFYISPEHRFQTLPELVHHHSYASDGLAAILHYPAAKSTKPAVYSMAPDYDEW 195

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+   ++ + ++LG G +G+V++    +          +AVKT + ++   E   E ++E
Sbjct: 196 EIDRSEIHMKQRLGGGQYGDVYEAVWKRYNK------TIAVKTFREDTTNTE---EFLKE 246

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIYQ 231
           A +M+++ H N+V+  GV     P Y++ E    G L   L + +      +    +  Q
Sbjct: 247 AAVMKSIKHPNLVQLLGVCTREPPFYIVTEFMSEGNLLEYLRRCNKVELDGVVLLHISVQ 306

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            A  + Y+  +N +HRD+AARNCL     ++
Sbjct: 307 VALAMEYLETRNYIHRDLAARNCLVEDNNLV 337


>UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y1_9METZ
          Length = 893

 Score =  307 bits (787), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 79/267 (29%), Positives = 139/267 (52%), Gaps = 23/267 (8%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           +  +  +++++  + R++ +E     G +L+R S        ++VL+V    +    HFV
Sbjct: 518 ETRVEEERWFYPNMERKEAEEKCKNTGDYLIRYSSKQ----NRYVLTVCWAGQG--KHFV 571

Query: 63  VRESDH-----KVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
           ++E+       K   +   FP++ EL++ +V+++   +   G + +      E  KW L 
Sbjct: 572 IQEAPDEQTKTKYRFESRSFPSVRELLDFHVNSQTPVTKASGAILSRP-ILREDDKWALK 630

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
           HED+++ +KLG+GAFG+VW+  L            VAVKT +  S      ++ ++EA +
Sbjct: 631 HEDIKMGRKLGKGAFGDVWEAALKGQG-------KVAVKTCR--STDVPDREKFLQEAEI 681

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANG 235
           ++  DH N+VK  GV+  TEP+ ++MEL  GG+L   L K        K   +   A  G
Sbjct: 682 LKQYDHPNIVKLIGVSWDTEPVLIVMELMPGGSLLDYLRKKAAQMTKGKLLHMSIDACGG 741

Query: 236 LAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + Y+  KN +HRD+AARNCL G   ++
Sbjct: 742 MEYLESKNCIHRDLAARNCLVGENDIV 768


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  307 bits (787), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 78/277 (28%), Positives = 125/277 (45%), Gaps = 32/277 (11%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGE---KKT 56
             +  +++Y G L R+D +  L    N  G FL+R SE  KG    + LS+      K  
Sbjct: 142 DSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGA---YSLSIRDWDDMKGD 198

Query: 57  SANHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKD------GTVKAVLKQA 108
              H+ +R+ D+  Y    +  F T+ +LV HY         +       G  +      
Sbjct: 199 HVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSV 258

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
             +  WE+  E ++L K+LG G FGEVW G              VA+KT K  +M+ E  
Sbjct: 259 KTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNG-------NTKVAIKTLKPGTMSPE-- 309

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKK 225
              + EA++M+ L H  +V+ + V +  EP+Y++ E  + G+L   L         +   
Sbjct: 310 -SFLEEAQIMKKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNL 367

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            ++  Q A G+AYI   N +HRD+ + N L G G + 
Sbjct: 368 VDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLIC 404


>UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni RepID=Q70DV1_SCHMA
          Length = 647

 Score =  306 bits (784), Expect = 6e-82,   Method: Composition-based stats.
 Identities = 76/280 (27%), Positives = 124/280 (44%), Gaps = 37/280 (13%)

Query: 5   DLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
            L   ++Y G L R + +  L    N  G FL+R SE       ++ LSV    + +  H
Sbjct: 216 SLESNEWYFGELKRIEAEHYLQLPGNDHGSFLVRISESQS---SEYSLSVRE--ENTVKH 270

Query: 61  FVVR-------ESDHKVYVDKI-GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER- 111
           + +R        +  + Y+ +   F  I +LVNHY+  +     + G             
Sbjct: 271 YRIRSRYSRTDPTLKRFYISRQLPFVNIQQLVNHYLENQSGLCCRLGKPCIRPTHPEPVG 330

Query: 112 ------QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTK 165
                  KWE+    + L +K+G+G FGEV+K          ++  +VAVKT K  S   
Sbjct: 331 LSHKLIDKWEIPKSSIILKEKIGQGQFGEVFKAVW-------NKTTIVAVKTLKPSSCDA 383

Query: 166 EQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPM 222
               + +REA+ M+ L H N+++ + V   TEP Y++ E    G+L + L         M
Sbjct: 384 A---DFLREAQTMKRLHHPNLIQLYAVCTQTEPFYIVTEYMSKGSLLNYLQSPEGNALNM 440

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                +  + A G+AY+  +  +HRD+AARN L G    +
Sbjct: 441 QCLIMMAAKIAPGMAYLESRRHIHRDLAARNVLVGEQHAV 480


>UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera RepID=SRC64_DROME
          Length = 552

 Score =  306 bits (784), Expect = 6e-82,   Method: Composition-based stats.
 Identities = 69/277 (24%), Positives = 119/277 (42%), Gaps = 31/277 (11%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVG---EKK 55
           ++ +  + ++   + R++  ++L    N  G FL+R SE        + LSV      + 
Sbjct: 154 ERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPN---GYSLSVKDWEDGRG 210

Query: 56  TSANHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ------ 107
               H+ ++  D+  Y       FP++  LV  Y                  +       
Sbjct: 211 YHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCPKPQPQMWDLG 270

Query: 108 AVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
              R K+E+   +++L +KLG G FGEV+ GK           + VAVKT +  +M+   
Sbjct: 271 PELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRN-------SIDVAVKTLREGTMSTAA 323

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIK 224
               ++EA +M+   H  +V  + V +  EP+Y++ E    G+L   L +          
Sbjct: 324 ---FLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFED 380

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
              +  Q A+G+ Y+  K L+HRD+AARN L G   V
Sbjct: 381 LIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNV 417


>UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax=Brugia malayi
           RepID=A8P4D4_BRUMA
          Length = 428

 Score =  305 bits (782), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 109/261 (41%), Positives = 157/261 (60%), Gaps = 9/261 (3%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA-N 59
           M   +L  + YYHGLLPRED+  +L   G FL+R+SE    + RQ ++S++ EK+ +   
Sbjct: 1   MGGGNLEDENYYHGLLPREDLPHLLINEGDFLVRSSETAPNQPRQVIISILVEKRGAILR 60

Query: 60  HFVVRESDHKVYVD--KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
           H VV+++ +  YV   +  F ++ EL+  Y    E         KAVLK+A+ R  WEL 
Sbjct: 61  HIVVQQNAYGKYVTDARASFDSVPELIQFYQKCGEPV--LSTVPKAVLKRAITRPPWELR 118

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
           HE V +  K+GEG FGEV+ GK         + + VA+K AK    +KE+IKE+M+EARL
Sbjct: 119 HETVIIENKIGEGEFGEVFSGKYKL---PTGRVIEVAIKLAKTAETSKEKIKEMMKEARL 175

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKY-ELIYQAANGL 236
           MRN +H NV++ +GV    +PL ++MEL DGGALD  L K    +  K  +++   A G+
Sbjct: 176 MRNYEHPNVIRMYGVCVEHDPLLIVMELVDGGALDDFLKKNRVSVKDKVEKMVAGGAWGV 235

Query: 237 AYIHEKNLMHRDVAARNCLYG 257
            Y+H KN +HRD+AARNCL  
Sbjct: 236 EYLHSKNCIHRDIAARNCLLT 256


>UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76978_9METZ
          Length = 879

 Score =  305 bits (782), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 74/260 (28%), Positives = 137/260 (52%), Gaps = 18/260 (6%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           +  + +YHG + R++   +L K G FL+R S     +K  + L+V  E      HF+++ 
Sbjct: 512 VEEEPWYHGEISRQEATGLLKKMGDFLVRYS----ADKEHYTLTVKMEG---IKHFIIQH 564

Query: 66  SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTK 125
           ++     +   +P+I  L++H+   +   + K   +     +  + +++ + H+++ + +
Sbjct: 565 NEEGFRFEGDPYPSIPMLIDHHFKNRLPVTRKSQAILRQPVKKPDLREYNISHDNILIGE 624

Query: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
           K+G+G FG+V+KG L          + VAVK+ + E       ++ ++EA +++   H N
Sbjct: 625 KIGKGNFGDVFKGYLKTHN------MEVAVKSCRSEDFP--DKQKFLQEAEILKQYRHPN 676

Query: 186 VVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIYQAANGLAYIHEK 242
           +V+  GV A  EPLY+IMEL  GG   S L         +    E+  +AA G+ ++ ++
Sbjct: 677 IVELIGVCAEKEPLYIIMELMAGGNFLSFLRGPEGKRLKVNNLTEMCVEAAAGMVFLEQR 736

Query: 243 NLMHRDVAARNCLYGGGQVL 262
           N +HRD+AARNCL G   VL
Sbjct: 737 NCIHRDLAARNCLVGDNNVL 756


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  304 bits (781), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 72/271 (26%), Positives = 122/271 (45%), Gaps = 29/271 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           KD+    +YH  + R   + +L     G FL+R S    GE   + +++  + K    H+
Sbjct: 121 KDINRNPWYHSNISRNTAEYLLKSGVDGSFLVRESLSSPGE---YSITLRCDGKAR-THY 176

Query: 62  VVRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDG-------TVKAVLKQAVERQK 113
            +       +V     F T+ +LV H+    +                K ++    E ++
Sbjct: 177 RINHDARGYFVAAGKFFATVEQLVAHHAVVADGLVACLKQHPVEKAEAKPLVLSKEEDEQ 236

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+   ++ L  +LGEG +GEV+ G+          P  VA+KT K  +M   + K+ M+
Sbjct: 237 WEIARSEIVLGHRLGEGQYGEVYVGEW--------GPHRVAIKTIKDGAM---EAKDFMK 285

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH----FPMIKKYELI 229
           EA +M+ + H N+V+  GV     PL+++ E  + G L   L                  
Sbjct: 286 EADIMKRMRHPNLVRLLGVCTRGGPLFIVTEFMNNGNLLDFLQSERGRAEIDPTSMMHCA 345

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
            Q A G++++ EK+ +HRD+AARNCL G   
Sbjct: 346 LQIAEGMSFLEEKHFIHRDLAARNCLVGDNL 376


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 90/295 (30%), Positives = 142/295 (48%), Gaps = 51/295 (17%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           ++ L  Q +YHG +PR ++Q++L K G FL+R S+   G    +VLSV      +  HF+
Sbjct: 520 ERPLEQQTWYHGAIPRLEVQQLLTKDGDFLVRKSQEKPG----YVLSVHWSG--ACKHFL 573

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           V+  D+   +D   F TI +L+  Y ++++  + K    + VL++ V + KW L H+D+ 
Sbjct: 574 VQNKDNMYCLDGESFHTIPQLIQQYQTSQQHVTKKS---EVVLRRPVLKDKWVLEHDDII 630

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA------- 175
           L   +G G FGEV+KG+L            VAVKT K  ++  EQ  + + EA       
Sbjct: 631 LGHIIGRGNFGEVYKGQLRP------DNTPVAVKTCK-NNLPLEQKSKFLIEARSAHTHT 683

Query: 176 -------------------------RLMRNLDHINVVKFFGVAAGTEPLYVIMELADG-G 209
                                    R+++  DH NVVK  GV    +P+Y++MEL  G G
Sbjct: 684 HTHTHTHTHTHAHAHAALYSHPTLSRILKQYDHPNVVKLIGVCTQKQPIYIVMELIQGSG 743

Query: 210 ALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              + L             ++    A+G+AY+  K  +HRD+AARNCL      +
Sbjct: 744 DFLTFLRNQGRDLKPKALVKMAENVASGMAYLESKKCIHRDLAARNCLVAENNSV 798


>UniRef50_P34265 Probable tyrosine-protein kinase kin-31 n=4 Tax=Caenorhabditis
           RepID=KIN31_CAEEL
          Length = 437

 Score =  303 bits (776), Expect = 5e-81,   Method: Composition-based stats.
 Identities = 111/264 (42%), Positives = 165/264 (62%), Gaps = 13/264 (4%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKK----TSAN 59
             +  + Y+HGL+ RED+ ++L+  G +++R S+P  GE R ++LSV+   K    +S  
Sbjct: 13  PTIEKEAYFHGLIQREDVFQLLDNNGDYVVRLSDPKPGEPRSYILSVMFNNKLDENSSVK 72

Query: 60  HFVVRESDHKVYVDKI-GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
           HFV+   ++K +V+    F TI ++++HY  ++      +      +   V RQ WEL H
Sbjct: 73  HFVINSVENKYFVNNNMSFNTIQQMLSHYQKSR-----TEILEACKILHPVRRQFWELDH 127

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
            ++ + KKLGEGAFGEV  G +        + V VAVK  K + + K+QIK+ + EAR M
Sbjct: 128 GNIVIEKKLGEGAFGEVSSGVMK--FKRGGRLVKVAVKQVKTDGIGKDQIKDFLMEARTM 185

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-FPMIKKYELIYQAANGLA 237
           RNL H N+V+F G+A   EPL+++MELA GGALDS L      P+ K++E++ QAA GL 
Sbjct: 186 RNLGHPNIVRFLGIAVLQEPLFLVMELATGGALDSYLKHNELLPIDKRHEMLLQAAWGLE 245

Query: 238 YIHEKNLMHRDVAARNCLYGGGQV 261
           YIH K ++HRD+AARNCLYG G+V
Sbjct: 246 YIHGKPMLHRDIAARNCLYGDGKV 269


>UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Suberites domuncula
           RepID=Q7YZX2_SUBDO
          Length = 700

 Score =  303 bits (776), Expect = 5e-81,   Method: Composition-based stats.
 Identities = 68/269 (25%), Positives = 121/269 (44%), Gaps = 26/269 (9%)

Query: 6   LLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           L  ++++   L R   + +L    + G F++R S      +  + LS+  E +    H  
Sbjct: 313 LDSEEWFFPQLSRTRAENILKGEGREGGFVVRNSSR----ENMYTLSICHEGQVRHYHIK 368

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE------RQKWEL 116
           + ES+     +K  FP+I EL+ ++        T+       L    +       + WE+
Sbjct: 369 LDESNKYFISEKHRFPSIKELIEYHKLNGGGLVTRLRKPPVQLAPNPQSLGPLFDEAWEI 428

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
               + L K+LG G FG V  GK           + VA+K  +  +M ++   + + EA+
Sbjct: 429 DKVSLSLGKELGSGQFGRVVSGKWKG-------KIDVAIKMMREGAMNED---DFIEEAK 478

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK---KYELIYQAA 233
           +M+   H N+VK +GV     P++++ EL   G L   L +    + K     ++  Q  
Sbjct: 479 VMKQFQHENLVKLYGVCTKNGPIFIVQELMVNGCLLQFLRQRKELVEKTEIILDMATQIC 538

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + + Y+ E   +HRD+AARNCL G   V+
Sbjct: 539 SAMKYLEESGFIHRDLAARNCLVGERNVV 567


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score =  302 bits (775), Expect = 7e-81,   Method: Composition-based stats.
 Identities = 73/276 (26%), Positives = 115/276 (41%), Gaps = 33/276 (11%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
            L    ++ G + R   ++ LN P    G FL+R SE   G   Q+ LS+      +  H
Sbjct: 231 SLESHAWFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPG---QYSLSLR--DGDTVRH 285

Query: 61  FVVRESDHKVY----VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE------ 110
           + V   +  +Y         F ++ EL+  +   K   +T            +       
Sbjct: 286 YRVENYEGGLYKLQGSPTQKFASLPELIAFHGQRKAGLATALREPCPKESAPMASDLTFD 345

Query: 111 -RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
              +WE+    ++L K LG G +GEV+ G              VAVKT K  S      K
Sbjct: 346 THDQWEVPRTSIKLGKLLGTGQYGEVYSGIF-------QDSTKVAVKTLKAASANP---K 395

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKY 226
           + + EA +M+ L H+N+V    V +   P+ +I+EL   G+L   L         +    
Sbjct: 396 DFLAEATIMKKLRHLNIVSLLAVCSVGSPILIIVELLSKGSLLDFLRSDDAKELRIPNLV 455

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           ++  Q A G+AY+     +HRD+AARN L G   V 
Sbjct: 456 DMGAQVAAGMAYLESMKFIHRDLAARNVLVGDNNVC 491


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score =  302 bits (774), Expect = 9e-81,   Method: Composition-based stats.
 Identities = 75/272 (27%), Positives = 120/272 (44%), Gaps = 27/272 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVG--EKKTS 57
           + L  ++++     R++ +  L    NK G FL+R SE  KG    F LSV     +   
Sbjct: 117 ESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGA---FSLSVKDVTTQGEL 173

Query: 58  ANHFVVRESD-HKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVK--AVLKQAVERQK 113
             H+ +R  D    Y+  +I FP++  LV HY    +    +          +    + +
Sbjct: 174 IKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDE 233

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+  + + L +KLG G FGEVW G            + VA+KT K  +M+ E     + 
Sbjct: 234 WEIPRQSLRLVRKLGSGQFGEVWMGYYKN-------NMKVAIKTLKEGTMSPEA---FLG 283

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIY 230
           EA +M+ L H  +V+ + V    EP+Y++ E    G L   L         + +  ++  
Sbjct: 284 EANVMKALQHERLVRLYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSA 342

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q A G+AYI   N +HRD+ A N L       
Sbjct: 343 QIAEGMAYIERMNSIHRDLRAANILVSEALCC 374


>UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax=Coelomata
           RepID=BMX_HUMAN
          Length = 675

 Score =  302 bits (774), Expect = 9e-81,   Method: Composition-based stats.
 Identities = 73/271 (26%), Positives = 122/271 (45%), Gaps = 23/271 (8%)

Query: 5   DLLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           +L    ++ G + R   +++L    K G F++R S  V           V +KK +  H+
Sbjct: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHY 349

Query: 62  VVRES-DHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK------ 113
            V  + ++K+Y+ +   F +I +L++++        T+     +     V          
Sbjct: 350 HVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGI 409

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WEL  E++ L K+LG G FG V  GK             VAVK  K  SM+++   E  +
Sbjct: 410 WELKREEITLLKELGSGQFGVVQLGKWKGQY-------DVAVKMIKEGSMSED---EFFQ 459

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQ 231
           EA+ M  L H  +VKF+GV +   P+Y++ E    G L + L          +  E+ Y 
Sbjct: 460 EAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYD 519

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              G+A++     +HRD+AARNCL      +
Sbjct: 520 VCEGMAFLESHQFIHRDLAARNCLVDRDLCV 550


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score =  301 bits (773), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 72/268 (26%), Positives = 122/268 (45%), Gaps = 26/268 (9%)

Query: 6   LLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           +  + ++HG + R +   +L    + G FL+R SE   GE   + LSV      S  H+ 
Sbjct: 297 IESEAWFHGRISRAEAAALLHVAKQEGCFLVRESESKVGE---YSLSVSH--GDSLRHYH 351

Query: 63  VRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE----RQKWELY 117
           +++   + Y+ D+  FP I +L+ ++        T+     A L           KWEL 
Sbjct: 352 IKKEGEEFYINDRHRFPDICKLIEYHKLNSGGLVTRLRKSIADLHTPAAAGLGHGKWELD 411

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
             D  + ++LG G FG V +   +           VAVK  K  +M+++   + + EA  
Sbjct: 412 PADFAIGRQLGSGQFGVVHEATYIG-------EKKVAVKMMKQGTMSED---DFISEALA 461

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPM--IKKYE-LIYQAAN 234
           M+N  H N+V+ +GV   T P+++I E+   G L   L          +  + +  Q A 
Sbjct: 462 MKNFTHPNLVQLYGVCTRTRPMWIITEIMTQGCLLDHLRNNQDLQHRPELLQYMGVQIAA 521

Query: 235 GLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + Y+     +HRD+AARNCL G   ++
Sbjct: 522 AMMYLESLRFIHRDLAARNCLLGEKYIV 549


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score =  300 bits (770), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 80/274 (29%), Positives = 127/274 (46%), Gaps = 30/274 (10%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNK---PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
           D  L    + HG + R     +L +    G +L+R S+   G   Q+ L V  E K+   
Sbjct: 66  DGSLELFDWCHGAISRNGADYLLKQHGIDGMYLVRESQSQPG---QYTLDVWKEGKSV-- 120

Query: 60  HFVVRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ------AVERQ 112
           H+ + + D   +    + FPTI EL+ H+ +  +   +    +                +
Sbjct: 121 HYRITKGDEGYFFRQGVCFPTIPELIQHHQTRSDGLCSSLDHIAPKAHAKTIVIGMDMEK 180

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           KWEL   +V L  +LG G +GEV+KG              VA+KT K ESM   +  E M
Sbjct: 181 KWELKRSEVILGDRLGGGNYGEVFKGIYNNK--------TVAIKTIKEESM---ETVEFM 229

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG----KLHFPMIKKYEL 228
           +EA +M+ L H N+VK  GV +   P+Y++ E    G L S L     ++    +    +
Sbjct: 230 KEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLRLPQSRIQLDHVSMLYI 289

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G++ +  +N +HRD+AARNCL G    +
Sbjct: 290 AQQIADGMSALEAQNTIHRDLAARNCLVGENLSV 323


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score =  299 bits (768), Expect = 5e-80,   Method: Composition-based stats.
 Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 29/270 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           L  + ++     +     +LN   + G FL+R SE   G    + LSV  + K    H+ 
Sbjct: 277 LESEPWFMADTSKAMASALLNMCGQDGAFLVRESESTPG---SYSLSVFYQGKL--KHYK 331

Query: 63  VRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE----RQKWELY 117
           ++       V ++  F +I EL+ ++        T+           +       +WEL 
Sbjct: 332 IKHDQDMYRVSERHTFASISELIEYHKHNGGGLVTRLRKPVQDANTPITAGLGHDRWELD 391

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
             ++EL ++LG G FG V  G              VA+K  K  SM+++   + + EA++
Sbjct: 392 AREIELGRELGSGNFGVVRAGVYKSNR-------PVAIKMMKEGSMSED---DFIAEAQV 441

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK-----KYELIYQA 232
           M    H N+V+  GV    +P+Y++ EL   G L   L K    M++      + +  Q 
Sbjct: 442 MMKFRHKNLVELLGVVTSVKPIYIVTELMSNGNLLDYLKKNQ-SMLQGKPQILHYMSVQV 500

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           A+G+A++ +   +HRD+AARNCL G   V+
Sbjct: 501 ASGMAFLEDHGFIHRDLAARNCLVGDNNVV 530


>UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes related) tyrosine kinase
           (phosphoprotein NCP94), partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E47E92
          Length = 527

 Score =  299 bits (767), Expect = 6e-80,   Method: Composition-based stats.
 Identities = 82/264 (31%), Positives = 145/264 (54%), Gaps = 16/264 (6%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           T+  L  +++YHG LPR++ + +L   G F++R      G   ++VLS     K    HF
Sbjct: 198 TELRLEEEEFYHGALPRKETEALLVNDGDFVVREKSDAWG---RYVLSAKHASK--VRHF 252

Query: 62  VVRESDHKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
            ++ +D  +Y ++   F T+ EL+   +++++  +     +       V R + +L HE+
Sbjct: 253 PIQINDENMYRLEGDAFQTVGELIRFQLNSRQPVTKASQAILLKPVCRV-RNEHDLRHEE 311

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           ++L +KLG G FG+V +G++ +        + VAVKT K E++     ++ ++EA +++ 
Sbjct: 312 IDLEEKLGAGHFGDVHRGRIKRTQ------LAVAVKTCK-ETVDAATRRKFLQEANILKQ 364

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYELIYQAANGLAY 238
            DH N+VK  GV     P+Y++MEL  GG L S L   +      ++ ++   AA+G+AY
Sbjct: 365 YDHANIVKLIGVCTDKHPIYIVMELVPGGDLLSFLRTDQNELSTKQRVKMGEDAASGMAY 424

Query: 239 IHEKNLMHRDVAARNCLYGGGQVL 262
           +  K  +HRD+AARNCL G   V+
Sbjct: 425 LESKQCIHRDLAARNCLVGNKNVI 448


>UniRef50_Q20933 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q20933_CAEEL
          Length = 444

 Score =  298 bits (764), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 130/257 (50%), Positives = 163/257 (63%), Gaps = 12/257 (4%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVV-GEKKTSANHFVVR 64
           +  Q ++HGLLPRE+++ +L K G +L+RTSEP  G+ R  ++SV+  E      H+V+R
Sbjct: 3   INEQPFFHGLLPREEVKLLLQKNGDYLMRTSEPQ-GQARHLIISVMQNETSQEVAHYVIR 61

Query: 65  ESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
            SD    + DKI F T+ ELVNH+   K S         +VL   + RQ WEL H D+ +
Sbjct: 62  TSDGAYSITDKIKFGTLTELVNHHKQAKISEEVAS----SVLVNPIGRQSWELNHADITM 117

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
           TK LGEGAFGEV  G L          V VA+K AKLE +TKEQIKEI+ EARLMR  DH
Sbjct: 118 TKVLGEGAFGEVKLGTLK----MGSTTVDVAIKVAKLEKVTKEQIKEIITEARLMRGFDH 173

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIHEK 242
            NVVK +GVAA  EPL V+MEL  GGALD  L K       +K ++I Q A GLAYIH K
Sbjct: 174 KNVVKCYGVAAIDEPLLVVMELVPGGALDKYLQKNSSVQWPEKLDIIAQVAAGLAYIHSK 233

Query: 243 NLMHRDVAARNCLYGGG 259
           N++HRD+AARN LYG G
Sbjct: 234 NIIHRDIAARNILYGKG 250


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score =  298 bits (763), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 83/262 (31%), Positives = 139/262 (53%), Gaps = 18/262 (6%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           K +  Q ++HG +PR +   +L + G FLLR S    G+   FVLS   + +    HF V
Sbjct: 463 KTIKEQTWFHGTIPRTESLRLLQQDGDFLLRESNNSLGD---FVLSAKADGQ--VRHFKV 517

Query: 64  RESDHKVY-VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           + +D+ +Y  +   FPT++ L++H+   +E  +        +L   + + KW+L H+D  
Sbjct: 518 QVTDNGMYRFEADQFPTVLNLISHHYQKREPVTK---RTNCLLLNPICKDKWQLSHDDFT 574

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           +  K+G+G FGEV+K   ++      +   VAVKT K E++     ++ + EA++++  D
Sbjct: 575 IDCKIGQGNFGEVYKALFIR------ENYYVAVKTCK-ETVDNNTKEKFLMEAKILKGYD 627

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIH 240
           H N+V+  GV    +P+Y++ME   GG L   L +           +  + A  GLAY+ 
Sbjct: 628 HKNIVRLIGVCTDRQPIYIVMEFVSGGDLVKYLKQNQHELCPRHLVQFCHDACMGLAYLE 687

Query: 241 EKNLMHRDVAARNCLYGGGQVL 262
           +K  +HRDVAARNCL     V+
Sbjct: 688 DKKCIHRDVAARNCLVSDDLVV 709


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score =  297 bits (762), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 68/274 (24%), Positives = 116/274 (42%), Gaps = 23/274 (8%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
            +  +   ++Y   + R   +++L    K G F++R S               G+ +   
Sbjct: 272 AEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVI 331

Query: 59  NHFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE------ 110
            H+VV  +    Y   +K  F TI EL+N++        ++     +   +         
Sbjct: 332 RHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG 391

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
              WE+  +D+   K+LG G FG V  GK             VA+K  K  SM+++   E
Sbjct: 392 YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQY-------DVAIKMIKEGSMSED---E 441

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYEL 228
            + EA++M NL H  +V+ +GV     P+++I E    G L + L   +  F   +  E+
Sbjct: 442 FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEM 501

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                  + Y+  K  +HRD+AARNCL     V+
Sbjct: 502 CKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVV 535


>UniRef50_Q7YSY1 Fes-like tyrosine kinase protein n=5 Tax=Schistosoma mansoni
            RepID=Q7YSY1_SCHMA
          Length = 1259

 Score =  293 bits (751), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 81/297 (27%), Positives = 141/297 (47%), Gaps = 52/297 (17%)

Query: 1    MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPV--------------------- 39
            + D D+  + ++HG+LPR +++ +L   G FL+R +                        
Sbjct: 811  ICDMDINKEPWFHGVLPRAEVERLLQNQGDFLVRQTSKRSSGRDTIGHWNGTNGDLINGN 870

Query: 40   ------------KGEKRQFVLSVVGEKKTSANHFVVR---ESDHKVYVDKIGFPTIIELV 84
                         G   + VLSV         HF++    E+    +++   F TI EL+
Sbjct: 871  HNETILNKDHNMDGTVLRMVLSVFWHG---HRHFILYGGPETGEGWHLEDGHFSTIRELI 927

Query: 85   NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKIL 144
             +++ T+   + K G   A L   + R  WEL + DV+L +K+G+G FG+V++G      
Sbjct: 928  EYHMKTQTPVTAKSG---ACLVTPISRPDWELDNRDVQLLQKIGQGNFGDVYRGVYNG-- 982

Query: 145  DANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIME 204
                    VAVKT +++    +  ++ ++      N +H N+VK  G+A  + P+ ++ME
Sbjct: 983  ------CEVAVKTCRVDMTASDLRRKFLQGETTALNFNHPNIVKLVGIAVQSYPIMIVME 1036

Query: 205  LADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
               GG+L + L K     P++K  ++   AANG+ Y+  +N +HRD+AARNCL    
Sbjct: 1037 YVPGGSLLNHLRKSKNALPVMKLLQMSLDAANGMMYLEARNCIHRDLAARNCLISDD 1093


>UniRef50_Q4S351 Chromosome 4 SCAF14752, whole genome shotgun sequence n=2
           Tax=Tetraodon nigroviridis RepID=Q4S351_TETNG
          Length = 810

 Score =  293 bits (751), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 88/261 (33%), Positives = 132/261 (50%), Gaps = 46/261 (17%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           +++ L  Q++YHG +PR + QE+L + G+FL                             
Sbjct: 470 SERPLAEQEWYHGAIPRTEAQELLRQQGEFL----------------------------- 500

Query: 62  VVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDV 121
                  +   +  GF TI +L+ H+ S+K+  + K G V  +L   V+ +KW L HEDV
Sbjct: 501 ------GQYRFEGTGFTTIPQLIEHHFSSKQVITKKSGVV--LLNPVVKDKKWILNHEDV 552

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
            L + LG+G FGEV+KG L +          VAVKT K +  ++ +I+  + EAR+++  
Sbjct: 553 VLGELLGKGNFGEVFKGTLQR------DKTPVAVKTCKEDLPSELKIR-FLSEARILKQY 605

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYI 239
           DH N+VK  GV    +P+Y++MEL  GG   S L K        +       AA G+AY+
Sbjct: 606 DHPNIVKLIGVCTQRQPIYIVMELVPGGDFLSYLRKKKDELKTKQLLRFAVDAAAGMAYL 665

Query: 240 HEKNLMHRDVAARNCLYGGGQ 260
             KN +HRD+AARNCL G   
Sbjct: 666 ESKNCIHRDLAARNCLVGDNN 686


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score =  292 bits (748), Expect = 9e-78,   Method: Composition-based stats.
 Identities = 68/270 (25%), Positives = 120/270 (44%), Gaps = 31/270 (11%)

Query: 6   LLHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L+   ++HG + RE  + +L   + G FL+R S    G+   + L V  + +   +H+ +
Sbjct: 96  LIPMPWFHGKISRELAESLLMPREDGLFLVRESAHFPGD---YTLCVCFQDQ--VDHYRM 150

Query: 64  RESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK--------W 114
           +  + K+ +D+ + F ++ ELV HY    +   T+    K V+KQ     K        W
Sbjct: 151 QGKNGKLTIDEEVYFSSLEELVQHYEKDADGLCTRLR--KPVVKQGGREFKIDARKFVNW 208

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+   ++  + ++G G FG+V++G              VA+KT K   +  + I + + E
Sbjct: 209 EISPREIVKSAQIGSGQFGDVFEGLYRGQ--------KVAIKTLKD--VQGDAIDQFLLE 258

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKYELIYQ 231
           A  M  L H N+V+  GV     P+ ++ E    G L   L         +  +      
Sbjct: 259 ADTMTRLRHKNLVQLIGVCTQGSPIMIVSEFMGKGCLLDYLRSRGRAVINLATQLGFCRD 318

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
               + Y+ E+  +HRD+AARN L     V
Sbjct: 319 ICAAMEYLEEQKFVHRDLAARNILLSDDGV 348


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score =  292 bits (748), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 72/271 (26%), Positives = 115/271 (42%), Gaps = 24/271 (8%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
             L  + ++ G   R +    L       G FL+R SE   G     V         +  
Sbjct: 106 NSLEVEGWFFGSCTRSEAIMRLQADNLPKGTFLVRESETRPGTYALTVRETDHGHPPTIK 165

Query: 60  HFVVRESDHK----VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE---RQ 112
           ++ V ++           +  F T+I++V  + S      +K                 +
Sbjct: 166 NYRVDKTKDGSELFFINPQRKFNTVIDVVKFHTSQPGGLCSKLLKPCPKQTPNTRTLGHE 225

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            WEL    ++L  KLG+G FG VWKG            V VAVKT +  +M+ E     +
Sbjct: 226 VWELPRSSLKLLDKLGQGQFGAVWKGIYDG-------KVEVAVKTLRPGTMSPEA---FL 275

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELI 229
            EA LM+ L H+ +V  +G+ +  EP+Y+I EL   G+L   L +    +  + +  ++ 
Sbjct: 276 AEANLMKELKHVKLVNLYGICSDEEPIYIITELMVNGSLLGYLREGGGQYLGLRELVDIA 335

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
            Q A G+ Y+  K  +HRD+AARN L G   
Sbjct: 336 AQIARGMNYLESKGYVHRDLAARNVLIGLNN 366


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score =  291 bits (745), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 71/274 (25%), Positives = 127/274 (46%), Gaps = 31/274 (11%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
            +  L    ++HG + R++ + +L   + G FL+R S    G+   + L V  + K    
Sbjct: 675 CEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGD---YTLCVCFQSK--VE 729

Query: 60  HFVVRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVL--------KQAVE 110
           H+ V+  ++K+ +D +  F  + +LV HY +  +   T+       L         +   
Sbjct: 730 HYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFV 789

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
            + W +   +++L + +G+G FG+V  G L            VAVK  K E      +++
Sbjct: 790 DKGWVIPEAELQLRESIGKGEFGDVMLGILRNE--------KVAVKMLKDEG----AVQK 837

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYE 227
            + EA +M  L+H N+VKF G+   ++ LY++ E    G+L   L    + H     +  
Sbjct: 838 FLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQII 897

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
             Y  A+G+ Y+  K ++HRD+AARN L     V
Sbjct: 898 FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCV 931


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score =  291 bits (745), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 71/274 (25%), Positives = 127/274 (46%), Gaps = 31/274 (11%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
            +  L    ++HG + R++ + +L   + G FL+R S    G+   + L V  + K    
Sbjct: 470 CEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGD---YTLCVCFQSK--VE 524

Query: 60  HFVVRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVL--------KQAVE 110
           H+ V+  ++K+ +D +  F  + +LV HY +  +   T+       L         +   
Sbjct: 525 HYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFV 584

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
            + W +   +++L + +G+G FG+V  G L            VAVK  K E      +++
Sbjct: 585 DKGWVIPEAELQLRESIGKGEFGDVMLGILRNE--------KVAVKMLKDEG----AVQK 632

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYE 227
            + EA +M  L+H N+VKF G+   ++ LY++ E    G+L   L    + H     +  
Sbjct: 633 FLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQII 692

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
             Y  A+G+ Y+  K ++HRD+AARN L     V
Sbjct: 693 FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCV 726


>UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata RepID=TEC_HUMAN
          Length = 631

 Score =  290 bits (744), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 65/274 (23%), Positives = 118/274 (43%), Gaps = 25/274 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
            +L   ++Y   + R   +++L    K G F++R S               GE  +   H
Sbjct: 240 NNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRH 299

Query: 61  FVVRES---DHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTV------KAVLKQAVE 110
           + ++E+     K Y+ +K  F +I E++ ++        T+           A       
Sbjct: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
            +KWE+   ++   ++LG G FG V  GK             VA+K  +  +M +E   +
Sbjct: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQY-------KVAIKAIREGAMCEE---D 409

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYEL 228
            + EA++M  L H  +V+ +GV    +P+Y++ E  + G L + L +   HF       +
Sbjct: 410 FIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSM 469

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                 G+ Y+   + +HRD+AARNCL     V+
Sbjct: 470 CQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVV 503


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score =  289 bits (742), Expect = 5e-77,   Method: Composition-based stats.
 Identities = 79/274 (28%), Positives = 123/274 (44%), Gaps = 26/274 (9%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKT 56
           +    +  Q ++ G + R      L    N  G FL+R SE    +   +VLSV    K 
Sbjct: 124 LARDSVESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSES---DDMGYVLSVR--TKE 178

Query: 57  SANHFVVRESDHKVYVDKI-GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ----AVER 111
           +A HF + ++  + YVD +  F +I+E++ HY S   S           +K         
Sbjct: 179 NAKHFKIFQTGDQFYVDALFKFSSIVEVIEHYQSHPLSIGDLLSEPCIRIKPENVPPPST 238

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
            +WEL  E+ +L  +LG G F +V+ GK             VA+K  K        ++E 
Sbjct: 239 DEWELPKEEFQLENQLGSGHFADVYSGKWKNHS-------KVAIKILKNNDAL--VLREF 289

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYEL 228
             E ++M+ L H +++  F V   + P Y+I EL + G L   L         M    ++
Sbjct: 290 QLEVQIMKRLRHKHLISLFAVCTSSSPFYIITELIEKGDLLHFLRNPEGRSLQMESLIDM 349

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G+AY+   N +HRD+AARN L G G V 
Sbjct: 350 AAQVADGMAYLEANNSIHRDLAARNVLVGDGYVC 383


>UniRef50_A8WMP8 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8WMP8_CAEBR
          Length = 284

 Score =  289 bits (741), Expect = 5e-77,   Method: Composition-based stats.
 Identities = 125/266 (46%), Positives = 161/266 (60%), Gaps = 19/266 (7%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN----- 59
            ++ + YYHGLLPRED   +L + G FL+R SEP  G ++ F+LS + + K+ +N     
Sbjct: 10  TIIREGYYHGLLPREDAAALLTQNGDFLIRISEPTDGAEQNFILSCMTDDKSKSNDENPG 69

Query: 60  --HFVVRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL 116
             +FVV   + +  V +   FPTI +LV  +   +             L + + RQ WEL
Sbjct: 70  MQNFVVGFQNGRYLVAENHSFPTIEKLVEFHKKNRI--------QNIFLNRPIMRQSWEL 121

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
            HE V + KKLGEGAFGEV  G+         +PV VAVK AK E +TK QIKE MREAR
Sbjct: 122 DHETVVILKKLGEGAFGEVSMGEYT--PKMGGKPVKVAVKQAKPEKLTKVQIKEFMREAR 179

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-FPMIKKYELIYQAANG 235
           +M+NL H NVVKF+GVAA  EPLY++MELA  G+LD  L K          E+I QAA G
Sbjct: 180 IMKNLSHENVVKFYGVAAVQEPLYMVMELASNGSLDGYLKKNPDLRPEVYNEMILQAAWG 239

Query: 236 LAYIHEKNLMHRDVAARNCLYGGGQV 261
           L Y HEKN++HRD+A RNCLYG  QV
Sbjct: 240 LEYCHEKNIIHRDMAVRNCLYGDRQV 265


>UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NNY7_BRUMA
          Length = 303

 Score =  288 bits (738), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 102/262 (38%), Positives = 148/262 (56%), Gaps = 14/262 (5%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
            D+    YYHGL+PR DI+ +L K G FLLR +E   GE    VL++      +  HF+V
Sbjct: 17  DDVKGADYYHGLIPRTDIEPLLKKEGDFLLRKTELTPGE---IVLAISVRHNNAVRHFMV 73

Query: 64  RE-SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
            +  D   Y +     ++ +L+ +Y STKE  S      +A L++ +ER +W L H+ + 
Sbjct: 74  NQDQDGSFYCEHHHEKSVSDLIQYYKSTKEPLSASS---QARLRRPIERPQWLLNHDSIR 130

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L KKLGEGAFGEV+  +         +   VAVKT + E+ T+E   + M+EARLMR  +
Sbjct: 131 LVKKLGEGAFGEVFLAEY----SFGTEKQEVAVKTMRQEA-TREARLKFMKEARLMRRYE 185

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIH 240
           H +VV+  GVA    PL +IME   GG+L S L K     P+  K     +AA+G+AY+H
Sbjct: 186 HKHVVRILGVAVHEHPLMIIMENCPGGSLLSYLRKEKVKVPLAMKLRFATEAADGMAYLH 245

Query: 241 EKNLMHRDVAARNCLYGGGQVL 262
           ++  +HRD+AARN L  G   +
Sbjct: 246 KQKCIHRDIAARNVLLSGKLDV 267


>UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QDY0_BRUMA
          Length = 384

 Score =  287 bits (736), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 101/262 (38%), Positives = 153/262 (58%), Gaps = 12/262 (4%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           +  L   ++YHGLLPR+DI  +L+K GQFL+R +E  KGE  Q VLSV    KT   HF+
Sbjct: 5   EPGLEFAEWYHGLLPRKDINILLSKQGQFLVRETEIKKGEGLQLVLSVKWNDKT--MHFI 62

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           +R  D KV+++K  F +I  L+ +++ +K+  + + G   A+L  AV RQ WE+ HE +E
Sbjct: 63  IRHVDGKVFIEKRQFNSIHALIRYHLVSKDPITDQSG---AMLLHAVPRQSWEVRHEQIE 119

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L + LGEGA   V+KG        +     VA+K  K   + +E +++I REAR+MR L+
Sbjct: 120 LHELLGEGAMSAVYKGIFRG----DESEKQVAIKVRKGRRLDRETVEQICREARIMRRLE 175

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAYIH 240
           H NVV+ +G+A   EP+ ++MEL   G+LD  L          +K       A+GL ++H
Sbjct: 176 HPNVVRLYGIAISKEPIMLLMELLKDGSLDVFLVTKGSKLSTREKLYFCLDIASGLEFLH 235

Query: 241 EKNLMHRDVAARNCLYGGGQVL 262
              ++HRD++ARNCL      +
Sbjct: 236 NNGVIHRDISARNCLV-EDMCV 256


>UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186E29F
          Length = 466

 Score =  287 bits (735), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 69/259 (26%), Positives = 124/259 (47%), Gaps = 31/259 (11%)

Query: 10  KYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
            ++       D ++ L    N+ G FL+R SE  + +   + LSV      +  H+ +  
Sbjct: 100 DWWLARSSSSDSEKKLLLPENEHGAFLIRDSESRRND---YSLSVR--DGDTVKHYRIDI 154

Query: 66  SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTK 125
               ++  K  F T+ ELV H  + ++  +               R +WE+  + ++  +
Sbjct: 155 RRRWIFCSKNNFRTLQELVEH--TIEKPVTGGLSHS--------TRDQWEIDRKSLKFVR 204

Query: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
           KLG G FG+VW+G         +    VA+KT K  +M     K+ + EA++M+ L H  
Sbjct: 205 KLGHGQFGDVWEGLW-------NNTTPVAIKTLKPGTMDP---KDFLAEAQIMKKLRHQK 254

Query: 186 VVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAYIHEKN 243
           +++ + V    EP+Y+I EL   G+L   L        + +  ++  Q A+G+A++  +N
Sbjct: 255 LIQLYAVCTMEEPIYIITELMKNGSLLEYLQGKGRQLKLAQLVDMAAQIASGMAFLESQN 314

Query: 244 LMHRDVAARNCLYGGGQVL 262
            +HRD+AARN L G G ++
Sbjct: 315 YIHRDLAARNVLVGDGNIV 333


>UniRef50_A8PMN8 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8PMN8_BRUMA
          Length = 420

 Score =  286 bits (734), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 83/261 (31%), Positives = 144/261 (55%), Gaps = 12/261 (4%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           +  + +YHG +   + + +L   G FL+R +E     + Q+V++V+ E      +F++++
Sbjct: 30  VEDEPFYHGFMSNNECKPLLTNAGDFLVRRAEIDG--EMQYVITVLPENSNEITNFIIKK 87

Query: 66  S--DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
           +   H  YV    F TI +L+ ++   K+  + ++      + + + R  W+L HE +E 
Sbjct: 88  TRPKHLYYVYIYAFKTISDLIAYHSRMKKPLNNEN----VCILKGIARSDWQLAHEQIER 143

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
            KKLGEGAFGEVW+G L   +   +  + VA+KT    +++ ++  + +REA LM  L H
Sbjct: 144 NKKLGEGAFGEVWEGTLNLGVFRGY--IPVAIKTLHSGNISADERIKFLREANLMLKLSH 201

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYELIYQAANGLAYIHE 241
            N++KF+GVA   +P+ ++ME A GG+L + +   K       K      AA+GLAY+  
Sbjct: 202 PNIIKFYGVATLKDPIMIVMEFASGGSLLARVQNTKRPPTDADKIRYCAGAASGLAYLET 261

Query: 242 KNLMHRDVAARNCLYGGGQVL 262
             ++HRD+AARNCL      +
Sbjct: 262 MQIIHRDIAARNCLLSADDEV 282


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score =  286 bits (733), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 71/266 (26%), Positives = 123/266 (46%), Gaps = 25/266 (9%)

Query: 5   DLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
            L    ++HG + RE+ + +L   + G FL+R S    G+   + L V   +K    H+ 
Sbjct: 372 KLNAMPWFHGRIKREEAENLLKPREDGLFLVRESTNFPGD---YTLCVCFNEK--VEHYR 426

Query: 63  VRESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK---WELYH 118
           ++ +++K+ +D    F  + +LV HY    +   TK        +  V+  +   WE+  
Sbjct: 427 IKYAENKLTIDDDEYFDNLGQLVEHYTLDSDGLCTKLMKALPKEEFCVKDFQDNGWEIKM 486

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           ED++L + +G+G FG+V  G L            VAVK  K       +    + EA +M
Sbjct: 487 EDLQLKENIGKGEFGDVMLGILKGE--------KVAVKVLKDAGRASNK---FLAEAGVM 535

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIYQAANG 235
             L+H N+VKF G+    + +Y++ E    G+L   L    + H     +    +   +G
Sbjct: 536 TTLEHENLVKFIGLVFHDKYIYLVTEYMSKGSLVDYLRSRGRQHITRRDQINFAFDTCSG 595

Query: 236 LAYIHEKNLMHRDVAARNCLYGGGQV 261
           + Y+  K ++HRD+AARN L     V
Sbjct: 596 MEYLEMKKVIHRDLAARNVLISEECV 621


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  286 bits (733), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 75/267 (28%), Positives = 129/267 (48%), Gaps = 23/267 (8%)

Query: 5   DLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVV--GEKKTSANH 60
           DL ++ ++HG + R + + +L   +PG FL+R SE +KG    + L+++   +     +H
Sbjct: 62  DLTNEPWFHGNIGRIEAENLLQYSEPGTFLIRESETIKG---SYTLTMIQIKDGTKQISH 118

Query: 61  FVVRESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLK-QAVERQKWELYH 118
           F +   D K ++     F  + +L+ HY+   +  +      +     + +E   WE+  
Sbjct: 119 FRINYDDGKYFITSARRFLGLHQLIQHYMQNSDGLACNLVYPQPKPSIEYMELDVWEIDR 178

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
             ++L  KLG G FG+VWKG L            VA+K  ++ +MT E     + EA+ M
Sbjct: 179 GRLKLETKLGSGGFGDVWKGTLDGSF-------TVAIKQLQIGTMTTEA---FLEEAKAM 228

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKYELIYQAANG 235
           + L H  +VK   V   TEP+Y++ E    G L S L +       +    ++  Q A+G
Sbjct: 229 KQLQHDKLVKLHAVVP-TEPVYIVSEFMCNGDLLSYLKRKGSYDLQLGDLLDMAAQVASG 287

Query: 236 LAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +A+I   N +HRD+ A N L G  +  
Sbjct: 288 MAFIEANNYIHRDLRAANILVGENKEC 314


>UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RNL0_TETNG
          Length = 509

 Score =  285 bits (731), Expect = 8e-76,   Method: Composition-based stats.
 Identities = 79/297 (26%), Positives = 123/297 (41%), Gaps = 68/297 (22%)

Query: 4   KDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQ-------------- 45
             +  +++Y G + R+D +  L    N+ G FL+R SE  KGE                 
Sbjct: 61  DSIQAEEWYFGKMGRKDAERQLLAHGNQRGTFLIRESETTKGEHSHAHTLRQLPGRGLYV 120

Query: 46  --------------FVLSVV---GEKKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYV 88
                         + LS+      K     H+ +R+ D+                 +Y+
Sbjct: 121 GYTSVPLHSRFPGAYSLSIRDWDDNKGDHVKHYKIRKLDNGG---------------YYI 165

Query: 89  STKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANH 148
           +T      K G  K        +  WE+  E ++L KKLG G FGEVW G          
Sbjct: 166 TTS----CKRGMPKLADLSVKTKDMWEIPRESLQLIKKLGNGQFGEVWMGMWNG------ 215

Query: 149 QPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADG 208
               VAVKT K  +M+ E     + EA++M+ L H  +V+ + V +  EP+Y+I E    
Sbjct: 216 -TTKVAVKTLKPGTMSPEA---FLEEAQIMKRLRHDKLVQLYAVVS-EEPIYIITEFMSQ 270

Query: 209 GALDSALGK---LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           G+L   L      +  + +  ++  Q A+G+AYI   N +HRD+ A N L G   V 
Sbjct: 271 GSLLDFLKDGEGQNLKLPQLVDMAAQIASGMAYIERMNYIHRDLRAANILVGDNLVC 327


>UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein tyrosine kinase n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E4736E
          Length = 387

 Score =  284 bits (729), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 76/272 (27%), Positives = 120/272 (44%), Gaps = 32/272 (11%)

Query: 8   HQKYYHGLLPREDIQEMLN----KPGQFLLRTSEPVKGEKRQFVLSVVGE---KKTSANH 60
              +  G+  R+D ++ L       GQF++R       +   F LSV      K     H
Sbjct: 4   DFCWDFGMCSRQDAEKKLMAIGINKGQFIVR-----DRDPGTFELSVRDNNPQKGDHVKH 58

Query: 61  FVVRESDHK---VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAV---ERQKW 114
           + + + D            FPT+ ELV HY    +    K                + KW
Sbjct: 59  YRIWKMDGGNSFFIFQGSVFPTVSELVRHYQMNSDGLCCKLTEACPKENPNTIGLGKDKW 118

Query: 115 ELYHEDV-ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           E   + + ++ ++LGEG FGEVW+G              VAVKT K  +M+       + 
Sbjct: 119 ETPRKSLGQMNRRLGEGKFGEVWQGVWNG-------NTPVAVKTLKERTMSPAA---FLA 168

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIY 230
           EA +M+ L H  +V+ + V +  EP+Y++ EL   G L + L      +  M    ++  
Sbjct: 169 EANVMKKLRHEGIVQLYAVCSDKEPIYIVTELMSNGDLRTYLKSDKCKNTKMTTLIDMGA 228

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             A+G+ Y+  KN++HRD+AARN L G G V+
Sbjct: 229 HIASGMDYLGSKNVVHRDLAARNVLVGKGNVV 260


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  283 bits (724), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 77/273 (28%), Positives = 127/273 (46%), Gaps = 34/273 (12%)

Query: 10  KYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
            +Y+G + R   +++L    NK G FL+R SE    E   + +S   E K    HF ++ 
Sbjct: 249 PWYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDE---YTISARSEGK--VFHFRIQR 303

Query: 66  SDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER-----------Q 112
           S    Y   D+I F T+ EL+++Y     S         A  +                +
Sbjct: 304 SSIGAYFVSDRISFATLGELISYYQRNNRSLGVLLEEPCAQQRPLTPSLLCLQRELFDME 363

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            WE   E+  L +KLGEG FGEVW+         + +   VA+KT K E   ++   E +
Sbjct: 364 PWERPREEFRLLRKLGEGHFGEVWEALW------STENRRVAIKTLKQEDTKQD---EFV 414

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELI 229
           +E + +++L H  +++   + +  EP+Y++ EL   G+L + L               + 
Sbjct: 415 KEVQALKSLHHPKLIQLLAMCSRGEPVYIVTELMTKGSLKAYLASAEGQVLTSAHLIYMG 474

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            Q A G+AY+ ++N++HRD+AARN L G   V 
Sbjct: 475 SQIAEGMAYLEDRNIVHRDLAARNILVGEDLVC 507



 Score =  235 bits (600), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 66/248 (26%), Positives = 118/248 (47%), Gaps = 25/248 (10%)

Query: 26  NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESD-HKVYVD-KIGFPTIIEL 83
           N  G FL+R SE    +   +VLSV    +    H+ V ++D ++ YV+    F ++ EL
Sbjct: 733 NSEGAFLIRVSEK---DNVGYVLSVRSGDQ--VKHYKVLQTDQNRFYVEPGRRFSSLAEL 787

Query: 84  VNHYVSTKESFSTKDGTVKA------VLKQAVERQKWELYHEDVELTKKLGEGAFGEVWK 137
           V++Y  T  + +   G                    WEL  ++ EL ++LG G F  V++
Sbjct: 788 VDYYQKTSLNNAGPLGNPCKRNTLSTPALLPFPTIGWELPKKEFELEEELGSGCFARVYR 847

Query: 138 GKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE 197
           G+   +       + VAVK  K +  ++    +   E ++++NL H +++  F V   + 
Sbjct: 848 GRWKNL-------IRVAVKILKSD--SELNHGDFQTEVQILKNLRHRHLLSLFAVCTESR 898

Query: 198 PLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNC 254
           P ++I EL + G+L   L      +  +    ++  Q A+G++Y+ E+  +HRD+AARN 
Sbjct: 899 PYWIITELMEKGSLLIFLRSPEGQNQDVASLIDMGTQVADGMSYLEEQKSIHRDLAARNV 958

Query: 255 LYGGGQVL 262
           L G     
Sbjct: 959 LVGEDYTC 966



 Score =  118 bits (298), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 46/171 (26%), Positives = 76/171 (44%), Gaps = 24/171 (14%)

Query: 7   LHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
             Q ++ G L R   Q  L    N  G FL+R SE    +   +VLSV    +    H+ 
Sbjct: 65  QTQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEK---DNVGYVLSVRSGDQ--VKHYK 119

Query: 63  VRESD-HKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKA------VLKQAVERQKW 114
           V ++D ++ YV+    F ++ ELV++Y  T  + +   G                    W
Sbjct: 120 VLQTDQNRFYVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLSTPALLPFPTIGW 179

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTK 165
           EL  ++ EL ++LG G F  V++G+   +       + VAVK  K  +++K
Sbjct: 180 ELPKKEFELEEELGSGCFARVYRGRWKNL-------IRVAVKILKSAAVSK 223


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score =  282 bits (722), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 67/271 (24%), Positives = 115/271 (42%), Gaps = 28/271 (10%)

Query: 6   LLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
           L    ++HG + RED +++L   K G+FL+R S+   G+   + L V  + +    ++ V
Sbjct: 104 LKTMPWFHGRISREDAEKLLTPPKNGRFLVRESQNYPGD---YTLCVSYDGR--VENYRV 158

Query: 64  RESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA--------VERQK 113
           R ++  +    D   F  +I+LV HY    +   T+         Q          + + 
Sbjct: 159 RRNEKGLVTVDDDEYFDNLIKLVEHYQKEADGLCTRLKAPVDKEGQHLFVVDVNDFKEKG 218

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           W +    +     +G+G FGEVW G              VA+K+ K     ++   + + 
Sbjct: 219 WAIPKASLLKKSLIGKGEFGEVWLGDYEGK--------KVAMKSMKDHLKDEKAKTQFLA 270

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKYELIY 230
           EA +M  L H N+V   G++    P+Y+I E    G+L   L            + +   
Sbjct: 271 EASVMTTLRHPNLVCLIGISLDDNPIYLITEFMAKGSLIDYLRSRGRAVITKQNQIDFAR 330

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
               G+ Y+  +N +HRD+AARN L     V
Sbjct: 331 DVVKGMVYLESQNFVHRDLAARNVLIAEDNV 361


>UniRef50_Q9TYX4 Putative uncharacterized protein R11E3.1 n=3 Tax=root
           RepID=Q9TYX4_CAEEL
          Length = 549

 Score =  280 bits (717), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 103/287 (35%), Positives = 150/287 (52%), Gaps = 36/287 (12%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVK------GEKRQFVLSVVGE---- 53
           K L    +YHG LPR+D+  ++   G +L+R SE         G KR  +LSV       
Sbjct: 73  KSLQAMPFYHGFLPRDDLGVIIRNEGDYLIRVSEITTKKEGTTGIKRDIILSVCSSERGG 132

Query: 54  ------------------KKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFS 95
                              +    + V+R  D K  +    FPTI  L+ +Y  T    +
Sbjct: 133 TETEQTNTKSDAKSELNLGERKMRNMVIRRFDGKFGIKGNLFPTIEALLANYHVTNALET 192

Query: 96  TKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAV 155
            ++      LK  ++ Q WE  H  V+L  KLGEGA+GEV KG L +     ++ + VAV
Sbjct: 193 KENR----FLKTPIDLQVWENRHSAVKLGDKLGEGAYGEVRKGVLHR----KNKKLDVAV 244

Query: 156 KTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL 215
           K  K   + K +I+E+M EARLMRN  H N+V+FFGVA   +PLY+++EL +GGAL++ L
Sbjct: 245 KLMKGGELNKMKIREMMNEARLMRNFKHKNIVRFFGVAVVEQPLYILLELVNGGALNTYL 304

Query: 216 GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            K     ++   +   AA GL Y+H  + +HRD+AARNCLY   +V+
Sbjct: 305 QKNKVSDLELMRMCLGAAQGLQYLHANHCIHRDIAARNCLYSNDKVV 351


>UniRef50_Q23554 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q23554_CAEEL
          Length = 419

 Score =  280 bits (717), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 97/265 (36%), Positives = 143/265 (53%), Gaps = 14/265 (5%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
           T K      +YHGLLPR DI  +L   G FL+RTS  V  +  + VLSV  + K   +H+
Sbjct: 23  TRKKHQDMDWYHGLLPRADINTLLENDGDFLVRTSHIVGQDSAKTVLSVKWKGK--CHHW 80

Query: 62  VVRES-DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
            ++E  D  + +++  F +++++V      +   S       A+L   + +Q WEL H+ 
Sbjct: 81  QLQEKEDGSIVIEERKFESVLDMVTTLRMKRLPVSA---NCPALLLNPINKQDWELRHDQ 137

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLES--MTKEQIKEIMREARLM 178
           ++L K LGEGAFG V+K           +  +VAVK  K      T+  I+++ +EAR+M
Sbjct: 138 IKLGKMLGEGAFGGVYKA----AFYCKGEKRMVAVKVNKGNEKISTRAMIEDVCKEARIM 193

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYELIYQAANGL 236
           R   H NVV FFGV    EP+ ++MELA  GALDS L   K +  +  K +  + A+ GL
Sbjct: 194 RQYQHPNVVCFFGVCVEKEPIMLVMELASQGALDSFLKNEKNNVSLRDKLKYSFDASKGL 253

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQV 261
            Y+H+   +HRDVAARN L     V
Sbjct: 254 EYLHQHGCIHRDVAARNFLMHKNVV 278


>UniRef50_O01798 Defective spermatogenesis protein 8 n=3 Tax=Caenorhabditis
           RepID=O01798_CAEEL
          Length = 512

 Score =  279 bits (715), Expect = 6e-74,   Method: Composition-based stats.
 Identities = 87/264 (32%), Positives = 141/264 (53%), Gaps = 15/264 (5%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           + ++ +  +YHG + R + + ML+  G FL+R +E   G++  +V+S+  + +    H +
Sbjct: 106 ENNIDNFPFYHGFMGRNECEAMLSNHGDFLIRMTEI--GKRVAYVISIKWKYQN--IHVL 161

Query: 63  VRESDHK--VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           V+ +  K   +  K  F +I EL+ ++    +        +       + R  W+L +E 
Sbjct: 162 VKRTKTKKLYWTKKYAFKSICELIAYHKRNHKPIYEGMTLIC-----GLARHGWQLNNEQ 216

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           V L KKLGEG FGEV KG L   + A   PV VAVKT     ++  +    +REA +M  
Sbjct: 217 VTLNKKLGEGQFGEVHKGSLKTSVFAA--PVTVAVKTLHQNHLSANEKILFLREANVMLT 274

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAY 238
           L H NV+KF+GV    EP+ ++ME  DG +L+ AL   +       K   ++ AA G+ Y
Sbjct: 275 LSHPNVIKFYGVCTMKEPIMIVMEFCDGKSLEDALLSKEEKVSAEDKILYLFHAACGIDY 334

Query: 239 IHEKNLMHRDVAARNCLYGGGQVL 262
           +H K ++HRD+AARNCL    ++L
Sbjct: 335 LHGKQVIHRDIAARNCLLNSKKIL 358


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score =  278 bits (713), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 67/271 (24%), Positives = 120/271 (44%), Gaps = 25/271 (9%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPG----QFLLRTSEPVKGEKRQFVLSVVGEKKTSA 58
            + +  + ++ G + R +    L   G     FL+R SE    +   +VLSV      + 
Sbjct: 70  RETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSAD---YVLSVR--DTQAV 124

Query: 59  NHFVVRESDHK--VYVDKIGFPTIIELVNHY--VSTKESFSTKDGTVKAVLKQAVERQKW 114
            H+ +           + + F ++ ELVN++   S            K   +       W
Sbjct: 125 RHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDW 184

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E   E+  L +KLG G FGEV++G            V VA+K    +++  +Q+  +  E
Sbjct: 185 ERPREEFTLCRKLGSGYFGEVFEGLWKD-------RVQVAIKVISRDNLLHQQM--LQSE 235

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIYQ 231
            + M+ L H +++  + V +  +P+Y+I EL   G+L   L        P+ +  ++ +Q
Sbjct: 236 IQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQ 295

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            A G+ Y+  +N +HRD+AARN L G   + 
Sbjct: 296 VAEGMCYLESQNYIHRDLAARNILVGENTLC 326


>UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona intestinalis
           RepID=UPI000180C4F3
          Length = 512

 Score =  277 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 70/270 (25%), Positives = 115/270 (42%), Gaps = 33/270 (12%)

Query: 11  YYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
           +      R +   +L    N  G FL R       E   + LSV      + NH  + + 
Sbjct: 131 WMFDTADRSEAVSLLMQPCNNHGDFLARRRTTNPNE---YALSVR--NGATVNHIKIEKM 185

Query: 67  DH-KVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER---------QKWE 115
                 +D    F T+ +LV +Y     +   +  +    +     +          +WE
Sbjct: 186 GGQGYSIDHHTMFATLNDLVGYYQENMLANDIRLRSPCKQVVMESPQTAGLSHDLADEWE 245

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVK-TAKLESMTKEQIKEIMRE 174
           +  + +EL +KLG+G FGEV+KG              VAVK   K + + KE   E ++E
Sbjct: 246 IDRKSIELKEKLGKGNFGEVYKGLWNG-------TTRVAVKKMIKSDLLDKE---EFLKE 295

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELIYQA 232
           A++M+ L H  +V+ + V   +EP Y++ EL   G+L   L +           E+  Q 
Sbjct: 296 AKIMKKLHHPKLVQLYAVCTHSEPFYIVTELMCNGSLREYLREKGKDLNEDTLIEMAIQV 355

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           A G+ Y+   + +HRD+AARN L G   + 
Sbjct: 356 ATGMVYLEVNDYIHRDLAARNILVGKNNIC 385


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score =  277 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 67/269 (24%), Positives = 115/269 (42%), Gaps = 29/269 (10%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNKP--GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
            L    ++HG + RE  + +L  P  G FL+R S    G+   + L V  + K    H+ 
Sbjct: 76  KLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGD---YTLCVSCDGK--VEHYR 130

Query: 63  VRESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-----WEL 116
           +     K+ +D+ + F  +++LV HY S  +   T+    K +      + +     W L
Sbjct: 131 IMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWAL 190

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
             ++++L + +G+G FG+V  G              VAVK  K ++  +      + EA 
Sbjct: 191 NMKELKLLQTIGKGEFGDVMLGDYRGN--------KVAVKCIKNDATAQA----FLAEAS 238

Query: 177 LMRNLDHINVVKFFGVAAGTEP-LYVIMELADGGALDSALGKLHFPM---IKKYELIYQA 232
           +M  L H N+V+  GV    +  LY++ E    G+L   L      +       +     
Sbjct: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
              + Y+   N +HRD+AARN L     V
Sbjct: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNV 327


>UniRef50_O17755 Protein F01D4.3, partially confirmed by transcript evidence n=2
           Tax=Caenorhabditis elegans RepID=O17755_CAEEL
          Length = 561

 Score =  276 bits (708), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 96/276 (34%), Positives = 150/276 (54%), Gaps = 25/276 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEK---RQFVLSVV--------G 52
             L    +YHG LPRED+   L+  G +L+R SE V+GE    R+ +LS++         
Sbjct: 143 MKLREFNFYHGFLPREDLHSTLHNSGDYLIRVSEVVEGETKVNREVILSLIPIQSDGKED 202

Query: 53  EKKTSANHFVVRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER 111
            +K +  + V++   +K + +    F ++ +L+ +Y     S S      +  LK  + +
Sbjct: 203 TEKKNCRNVVIKRVGNKCFCEPTRTFESVTDLIKYYTDNSGSCSNG----RFQLKNPILQ 258

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLES-MTKEQIKE 170
           Q WE  H DV   K LGEGAFG+V+ G L      +     VA+K  K+ + ++K +IKE
Sbjct: 259 QPWEYMHSDVTAGKVLGEGAFGKVFSGTLKL---KDGSSAEVAIKMTKVSAFLSKIKIKE 315

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-----FPMIKK 225
           +M EAR +RN +H NVV+ +GVA   +PLY+++EL  GG+L   + K        P+ +K
Sbjct: 316 MMNEARFIRNFNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDHMKKAKATGTVVPIAEK 375

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
                 AA G+ Y+H+ N +HRD+AARNCL    +V
Sbjct: 376 VRFCIGAARGIEYLHQNNCIHRDIAARNCLLSEKEV 411


>UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=O01325_CAEEL
          Length = 474

 Score =  276 bits (706), Expect = 7e-73,   Method: Composition-based stats.
 Identities = 92/261 (35%), Positives = 141/261 (54%), Gaps = 14/261 (5%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSE-PVKGEKRQFVLSVVGEKKTSANHFVVR 64
           L  + +YHG + RE+ ++++   G+FLLR +E   +GE    VLSV  +     +H VV 
Sbjct: 86  LDDEPFYHGYMSREESEKLVRSQGEFLLRKTELTKRGE--VVVLSVFWD--EGVHHLVVE 141

Query: 65  ESDHK-VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
           ++++   Y+ +  F  I +LV ++  T+ S           L   V R++W+LYHE + L
Sbjct: 142 KANNGLYYLKEFCFENISDLVRYHHQTRASVYKSGIK----LFSWVVREEWQLYHEQINL 197

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
            KKLG G FGEV++G L   +  N   V VAVKT K   +T ++    +REA LM  L+H
Sbjct: 198 GKKLGNGEFGEVFQGVLSVGIFTND--VEVAVKTMKGSKVTADERITFLREANLMLKLNH 255

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKY--ELIYQAANGLAYIHE 241
             VV+ +GVA   EP+ ++MEL  GG L S + K    +      +   Q A G+ Y+ +
Sbjct: 256 KYVVRLYGVATQQEPIMIVMELCSGGCLKSRIEKKDEQLSDVLKRKYCKQIAKGMRYLEK 315

Query: 242 KNLMHRDVAARNCLYGGGQVL 262
           K ++HRD+AARN L       
Sbjct: 316 KQVIHRDLAARNVLLDKSDNC 336


>UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7QBP3_IXOSC
          Length = 626

 Score =  274 bits (702), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 71/279 (25%), Positives = 123/279 (44%), Gaps = 37/279 (13%)

Query: 6   LLHQKYYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSVVGEK-KTSANHF 61
           L   ++Y G + R+  +++L    K G F++R S         F LS++      S    
Sbjct: 239 LWQHEWYAGDMSRQRAEQVLRQETKEGAFVVRNSSTQG----FFTLSLLANSIMNSWASS 294

Query: 62  VVRESDHKVYVDKIGFPTIIELVNHYVS-------------TKESFSTKDGTVKAVLKQA 108
           + +   HK+        T   L NH +S                 +  ++   +      
Sbjct: 295 LFKSLRHKIEATDQYLETSYAL-NHAMSIMVFERRGKDCLFRNSCYYCQNSCCQPDSTNN 353

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
               KWE+   ++ L ++LG G FG V +GK             VAVK  K  +M+++  
Sbjct: 354 PSLDKWEIDPSELALLEELGSGQFGVVRRGKWRGCR-------DVAVKMMKEGTMSED-- 404

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK---- 224
            + + EA+LM  L H N+V+ +GV +   P++++ E    G+L   L +    + +    
Sbjct: 405 -DFIEEAKLMTKLQHPNLVQLYGVCSKHRPIFIVAEYMKHGSLLHFLRRHEKALSERGPL 463

Query: 225 -KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              ++  Q A+G+AY+   N +HRD+AARNCL G   V+
Sbjct: 464 LLLDVCLQVASGMAYLELHNYIHRDLAARNCLVGENYVV 502


>UniRef50_Q9N4T6 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q9N4T6_CAEEL
          Length = 448

 Score =  274 bits (702), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 100/269 (37%), Positives = 151/269 (56%), Gaps = 22/269 (8%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEK---RQFVLSVV-------- 51
           +  L H ++YHG LPRED+Q  L  PG FLLR SE V+GE    R+ +LS++        
Sbjct: 71  ELALRHFEFYHGFLPREDLQSTLQNPGDFLLRVSEVVEGENKVNREIILSLIPIQEEGKE 130

Query: 52  GEKKTSANHFVVRESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVE 110
            E K    + V++ + +  + +    F +I EL+N+Y+    S S+        L   + 
Sbjct: 131 DEDKIRTRNVVIKRAGYLFFCETTRSFDSIFELINYYMKNTGSCSSAT----FQLLNPIL 186

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLES-MTKEQIK 169
           +Q WE  H DV + K LGEGAFG+V  G L      +   V VA+K  K+ + ++K +IK
Sbjct: 187 QQPWEYMHSDVTIGKVLGEGAFGKVCSGTLKL---KDGSNVEVAIKMTKVSAFLSKMKIK 243

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYE 227
           E+M EAR +RN +H NVV+ +GVA   +PLY+++EL  GG+L   + K      + ++  
Sbjct: 244 EMMNEARFIRNFNHKNVVRLYGVAHHEQPLYILLELVKGGSLQDHMKKEKGAVTIAERIR 303

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLY 256
               A  G+ Y+H+ N +HRD+AARNCL 
Sbjct: 304 FCCGAGRGIEYLHQNNCIHRDIAARNCLL 332


>UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYY1_SCHMA
          Length = 481

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 68/269 (25%), Positives = 111/269 (41%), Gaps = 34/269 (12%)

Query: 11  YYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS----ANHFV 62
           +Y   + R +    L    N  G +L+R S     E + + LSV             H+ 
Sbjct: 97  WY--NIGRREADRKLLLVGNPKGTYLIRPSS----ETQNYALSVRHYDSEKNMWVVKHYR 150

Query: 63  VRESDH--KVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ-KWELYH 118
           +R  D+    ++  +  FP I +LVN+Y    +    +         +   +   +E+  
Sbjct: 151 IRILDNNGGFFISIRTTFPNIQDLVNYYTVHPDGLCCRLSIPCPRAYRPPVQFRDFEINR 210

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           + +   +KLG+G FGEV+  K           V VAVK      +        + EARLM
Sbjct: 211 DSITRIRKLGQGTFGEVYLAKWNG-------SVEVAVKM----RLDPTDRSRFIEEARLM 259

Query: 179 RNLDHINVVKFFGVAAGTE--PLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAA 233
               H  +V+  GV    E  P+Y+I EL   GAL   L         +    +++ Q A
Sbjct: 260 HAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHKLTLDDLIDIMAQIA 319

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +G++Y+ E N +HRD+ A N L      +
Sbjct: 320 SGMSYLEEMNSVHRDLRAANILVDQDYSV 348


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 76/272 (27%), Positives = 128/272 (47%), Gaps = 29/272 (10%)

Query: 6   LLHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV- 62
           L    ++ G + RE  +E+L   + G FL+R S    G+    V+S    KK    H+  
Sbjct: 87  LHEMPWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKK--VEHYRV 144

Query: 63  VRESDHKVYVDKIGF-PTIIELVNHYVSTKESFSTKDGTV---------KAVLKQAVERQ 112
           +  SD++V VD+  F PT+IEL+ HY    +   T               A+ K++ +++
Sbjct: 145 ISTSDNQVTVDEEAFFPTLIELIKHYEKDADGLCTMLKKPLKKKTEILQSAIFKESFQKE 204

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            W +  EDVE  + +G+G FG V+KG   K          VA+K  + +S T    + ++
Sbjct: 205 GWAVPIEDVEFKELIGKGEFGNVYKGVWAKK--------TVAIKKLRDDSKTA---QSLL 253

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELI 229
            EA +M  L H N+V    ++   + + ++ E  + G L   L    +    + ++    
Sbjct: 254 AEASVMTTLQHKNLVVLVAISFQGDSILILTEYCEKGVLVEYLRTRGRAVITLEEQKGFA 313

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
               NG+ Y+ EKN++HRD+AARN L      
Sbjct: 314 IDVCNGMRYLEEKNIIHRDLAARNVLLSDELC 345


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 72/277 (25%), Positives = 119/277 (42%), Gaps = 34/277 (12%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           +  L    ++HG + R D +++L   K G FL+R S    G+   + + V    +    H
Sbjct: 100 EVKLTAMPWFHGKITRSDAEDLLTPRKDGLFLVRESTNYPGD---YTMCVSFAGE--VEH 154

Query: 61  FVVRESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKD--------GTVKAVLKQAVER 111
           + V   D+KV + ++  F  + +LV HY    +              G   +V  +   +
Sbjct: 155 YRVIFKDNKVTIDEEEYFENLTKLVEHYERDADGLVCTLTQPLIKKGGHEYSVDTEEFRK 214

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             W +   D++L   LG+G FG+V++G              VAVK+ K  S   +     
Sbjct: 215 SGWAINFTDLKLGTILGKGDFGDVYEGTYKDQ--------KVAVKSVKDRSKAAQA---F 263

Query: 172 MREARLMRNLDHINVVKFFGVA----AGTEPLYVIMELADGGALDSALGKLH---FPMIK 224
           + EA +M  L H N++K  GV        +P+YV++E    GA+   L            
Sbjct: 264 LAEASVMTQLHHKNLIKLLGVVIPQTMSNDPIYVVLEFMTKGAMLEYLRSRGRALVTSND 323

Query: 225 KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
            ++     A G+ Y+  K L+HRD+AARN L     V
Sbjct: 324 LWKFAKDIALGMEYLENKQLVHRDLAARNILISEECV 360


>UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosine kinase 6 n=1 Tax=Danio
           rerio RepID=UPI000175FB8C
          Length = 510

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 77/276 (27%), Positives = 132/276 (47%), Gaps = 29/276 (10%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVV-GEKKTS 57
            + +  Q +Y G L R + + +L    N  G FL+R SE    +   +VLSV+ G++   
Sbjct: 115 RQTVKEQPWYFGTLNRFETEILLLAPENDVGAFLVRHSEK---DNIGYVLSVLSGDRSRE 171

Query: 58  ANHFVVRESDH-KVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER---- 111
             H  + ++ +   Y+DK   F ++ +LV++Y        +         +   +     
Sbjct: 172 VKHIKIHQNQNESFYLDKSQTFQSLEKLVDYYWKYSLDGDSFLKQPCRRPEPKPKDLSHS 231

Query: 112 --QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
               WEL  E+  L ++LG+G F +V++GK   +       V VA+K  K +S+     +
Sbjct: 232 TVNDWELPKEEFTLEEELGKGFFADVYRGKWKGM-------VNVAIKILKNDSINH---R 281

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKY 226
           E M E ++++ L H +++  F V   + P Y+I EL + G L S L              
Sbjct: 282 EFMLETQILKKLRHKHLIALFAVCTSSSPFYIITELMEKGDLLSLLKGKEGQDLNAQMLT 341

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           E+  Q A+G+AY+ E+N +HRD+AARN L G   + 
Sbjct: 342 EMASQVADGMAYLEEQNSIHRDLAARNVLVGANYIC 377


>UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2 Tax=Eumetazoa
           RepID=UPI0001925126
          Length = 914

 Score =  273 bits (698), Expect = 6e-72,   Method: Composition-based stats.
 Identities = 59/269 (21%), Positives = 123/269 (45%), Gaps = 27/269 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             +    +YH  + R++  +++     G FL+R +     + + + LS   +      H+
Sbjct: 540 PRVEKLLWYHADMTRQEADQVMQNTNDGTFLVRNAS----KPKMYTLSFSFQG--VVKHY 593

Query: 62  VVRE-SDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAV---ERQKWEL 116
            ++  SD+  YV  +  F ++++L+ ++       +T+                   +++
Sbjct: 594 HIKTDSDNLFYVSQRHSFESVVQLIEYHKLNSAGLATRLRFPYTGTNNPPVLLGYGVFQI 653

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
              ++ + K++G G FG V +              LVAVK  K +SM++    + + EA+
Sbjct: 654 NRNELTIMKQIGTGQFGTVHEALWKNNK-------LVAVKMMKPDSMSEN---DFIEEAK 703

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIYQAA 233
           +M+   H N++  +GV   T PLY+++EL   G+L   L              ++I + +
Sbjct: 704 VMQRFQHRNLITLYGVCT-THPLYIVVELMKNGSLLDYLRNNKQLLEKTQVLIDIILKVS 762

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + + Y+ +   +HRD+AARNCL G   ++
Sbjct: 763 SAMEYLEKNKFIHRDLAARNCLVGENNMI 791


>UniRef50_P91360 Putative uncharacterized protein n=3 Tax=root RepID=P91360_CAEEL
          Length = 577

 Score =  269 bits (689), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 93/295 (31%), Positives = 150/295 (50%), Gaps = 41/295 (13%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEK------------------- 43
           +  +     +HG + RED  ++L  PG +L+R S P   ++                   
Sbjct: 164 EDYITKMPNFHGYICREDAAQILKHPGDWLVRLSVPPSNDQDKKNKAQNLAKSVERTKGH 223

Query: 44  -----RQFVLSVVGEKK------TSANHFVVRESDHKVYVDKIGFP-TIIELVNHYVSTK 91
                + FV+SV+ + K      ++  + V++ ++ K  +D + +   + +L +HY  T 
Sbjct: 224 KSTMQKVFVISVLCKGKALSPAKSNNRNLVIKTNNGKFSIDSVHWLVKLKDLFSHYQGTS 283

Query: 92  ESFSTKDGTVKAVLKQAVERQKWELYHEDVELT-KKLGEGAFGEVWKGKLLKILDANHQP 150
                     +  L   +   KWE  HED EL  KKLGEGAFGEV  G+L    D   + 
Sbjct: 284 AVHKNG----EFQLLNPISLSKWEFQHEDTELLAKKLGEGAFGEVRVGRLT-TKDPKKKL 338

Query: 151 VLVAVKTAK--LESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADG 208
           V VAVK  K   +S+T++Q++E++ E R+MR LDH NV++ +GVA   EPLY+++EL   
Sbjct: 339 VEVAVKMLKSSADSVTRDQVEELLHETRIMRKLDHPNVLRSYGVAVLREPLYLMIELCSN 398

Query: 209 GALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
           GAL   L + H    +  K   +  +A G+AY+H + ++HRD+A RN L    + 
Sbjct: 399 GALREYLKENHKTITLADKINFVLGSARGVAYLHSQRILHRDLAVRNILLTEDKT 453


>UniRef50_UPI00004D86FC Tyrosine-protein kinase Tec (EC 2.7.10.2). n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=UPI00004D86FC
          Length = 647

 Score =  268 bits (686), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 66/253 (26%), Positives = 111/253 (43%), Gaps = 23/253 (9%)

Query: 23  EMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES--DHKVYV-DKIGF 77
           +ML   K G F++R S               GE  T   H+ ++E+    K Y+ +K  F
Sbjct: 303 QMLQIDKEGGFIVRNSSQAGLYTVSLYTKYGGEGSTCIRHYHIKETQYPKKYYLAEKHVF 362

Query: 78  PTIIELVNHYVSTKESFSTKDGTV------KAVLKQAVERQKWELYHEDVELTKKLGEGA 131
            TI E++ ++        T+           A         KWE+   ++   K+LG G 
Sbjct: 363 NTIPEMIEYHKHNAAGLVTRLRYPVCSKNKSAPTTAGFSYDKWEINPSELTFMKELGSGL 422

Query: 132 FGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFG 191
           FG V  GK             VA+K  +  +M++E   + + EA++M  L H+ +V+ +G
Sbjct: 423 FGVVRLGKWRAQY-------KVAIKAIREGAMSEE---DFIEEAKVMMKLTHLKLVQLYG 472

Query: 192 VAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
           V     P+Y++ E  + G L + L + H  F       +       ++Y+ + N +HRD+
Sbjct: 473 VCTQQRPIYIVTEFMEHGCLLNYLRQRHGQFSPDILLSMCQDVCEAMSYLEQNNFIHRDL 532

Query: 250 AARNCLYGGGQVL 262
           AARNCL     V+
Sbjct: 533 AARNCLVNDAGVV 545


>UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californica
           RepID=B6DVV3_APLCA
          Length = 517

 Score =  267 bits (684), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 81/267 (30%), Positives = 123/267 (46%), Gaps = 29/267 (10%)

Query: 7   LHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGE----KKTSA 58
             Q ++     R++  +ML    N  G FL+R +     +K  +VLSV        +   
Sbjct: 123 QTQDWWFEF-DRKESDKMLLLPGNPRGTFLVREAT----DKSTYVLSVRDNDKASGEPCV 177

Query: 59  NHFVVRESDH--KVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWE 115
            H+ VR+ D     ++  K  F T+ +++ HY    +    + G      +  V+ ++ E
Sbjct: 178 KHYRVRKMDDERGYFISAKKTFKTLFDVIEHYKDNSDGLCCQLGAACPRSRPTVQFRELE 237

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +  E +ELT KLG G FGEVWKGKL K+       V VAVKT K  +M+ E     + EA
Sbjct: 238 IKREVIELTNKLGAGCFGEVWKGKLRKV-------VEVAVKTLKPGTMSSEA---FLNEA 287

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIYQA 232
           ++M  L H  +V+   V +  EP  +I EL   GAL   L              ++  Q 
Sbjct: 288 KIMHKLTHAKLVQLMAVVSVQEPFLIITELMVNGALLDYLRSEEGKKLKFDVLIDMNAQV 347

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGG 259
           A G+ Y+   N +HRD+ A N L G  
Sbjct: 348 AEGMTYLESVNFVHRDLRAANILVGEH 374


>UniRef50_UPI0000ECD739 Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow
           tyrosine kinase gene in chromosome X protein)
           (Epithelial and endothelial tyrosine kinase) (ETK)
           (NTK38). n=2 Tax=Gallus gallus RepID=UPI0000ECD739
          Length = 633

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 65/270 (24%), Positives = 121/270 (44%), Gaps = 24/270 (8%)

Query: 7   LHQKYYHGLLPREDIQEMLNKP---GQFLLRTSEPVKGEKRQFVLSVVG-EKKTSANHFV 62
             + +Y   + R   +++L++      F +  ++  +    +      G  KK +  H+ 
Sbjct: 246 NQEIWYVAGISRAQSEQLLHQSPKISGFTVALAQMSRLYTSKMKSPFYGENKKGTVKHYH 305

Query: 63  VRESD-HKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK------W 114
           V ++  +K Y+ +   F TI +L+N++         +   V +     V          W
Sbjct: 306 VHKTPENKYYLTENHCFETIPKLINYHQHNSAGMVPRLRHVVSTQINKVPATASLGNGIW 365

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           EL  E++   ++LG G FG V  GK   +         VAVK  K   ++++   E + E
Sbjct: 366 ELKREEIVPLRELGSGQFGAVHLGKWKGLY-------DVAVKMIKEGVVSED---EFVEE 415

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQA 232
           A+ M  L+H  +V+ +GV +   P+Y++ME    G+L S L         ++  E+ Y  
Sbjct: 416 AQTMMKLNHPKLVRLYGVCSKLYPIYLVMEYMPNGSLLSYLQIHGKELQPLQLLEICYDV 475

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + +A++    L+HRD+AARNCL      +
Sbjct: 476 CDAMAFLESCQLIHRDLAARNCLVDSNLTV 505


>UniRef50_Q19726 Protein F22D6.1, partially confirmed by transcript evidence n=5
           Tax=root RepID=Q19726_CAEEL
          Length = 418

 Score =  264 bits (675), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 86/265 (32%), Positives = 135/265 (50%), Gaps = 26/265 (9%)

Query: 7   LHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE- 65
            + +++HG+L R+D  E+L KPG FLLR SE     K   +LSV  + K    +  V   
Sbjct: 26  QNNEWFHGVLQRQDADELLVKPGSFLLRASEVHG--KMSMILSVRHDGKLH--NIAVNSD 81

Query: 66  SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTK 125
           +    + +     +I +LV  +++T    +   G     LK  + +  W + HE+V   K
Sbjct: 82  TGENFWFEGHREKSIDQLVQWHMTTSTPITKTSG---VKLKYPIGKADWIISHENVIFIK 138

Query: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
           KLGEGAFGEV   +     +   + V  AVKT + + MT++     M+EARLMR   H +
Sbjct: 139 KLGEGAFGEVSLAEC----EIGGRKVETAVKTMRCQ-MTRDTRAAFMKEARLMRKYSHPH 193

Query: 186 VVKFFG-----------VAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQA 232
           +V+  G           +A    PL ++ME+   G+L S L K      + ++     ++
Sbjct: 194 IVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHGSLLSFLRKNKGKTTLSERLRFCIES 253

Query: 233 ANGLAYIHEKNLMHRDVAARNCLYG 257
           A+GLAY+ +K  +HRD+AARNCL  
Sbjct: 254 ADGLAYLEKKQCLHRDIAARNCLLS 278


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score =  262 bits (671), Expect = 8e-69,   Method: Composition-based stats.
 Identities = 79/272 (29%), Positives = 131/272 (48%), Gaps = 29/272 (10%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS 57
           + + L  Q +Y   + R   Q++L    N+PG FL+R SE   G    + LSV    +  
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLG---GYSLSVRA--QAK 165

Query: 58  ANHFVVRES-DHKVYVDKIG-FPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWE 115
             H+ V  + D  +Y+ K   FP + EL+ +Y +  +           + ++A  +  WE
Sbjct: 166 VCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPC-MPQKAPRQDVWE 224

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
             H +  L +KLGEG FGEVW+G  L         + VA+K  K  +M   ++ ++ +E 
Sbjct: 225 RPHSEFALGRKLGEGYFGEVWEGLWLG-------SLPVAIKVIKSANM---KLTDLAKEI 274

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL-----GKLHFPMIKKYELIY 230
           + ++ L H  +++   V +G EP+Y++ EL   G L + L       L  P         
Sbjct: 275 QTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPP--LLGFAC 332

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q A G++Y+ E+ ++HRD+AARN L   G   
Sbjct: 333 QVAEGMSYLEEQRVVHRDLAARNVLVDDGLAC 364


>UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E52F9
          Length = 588

 Score =  259 bits (664), Expect = 5e-68,   Method: Composition-based stats.
 Identities = 66/275 (24%), Positives = 116/275 (42%), Gaps = 38/275 (13%)

Query: 11  YYHGLLPREDIQEMLN---KPGQFLLRTSEPVKGEKRQFVLSV-------VGEKKTSANH 60
           +Y   + R   QE+L    K G F++R S         + +SV        GEK     H
Sbjct: 213 WYSKNMNRMQAQELLMREGKEGAFMVRDSS----HMGVYTVSVFTKAPSQSGEKNPKVKH 268

Query: 61  FVVRESDHK----VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAV-------LKQAV 109
           + +R+++         +   F TI EL++++        T+     +        +    
Sbjct: 269 YQIRQTETGAGPFYLAENYLFNTIPELIHYHQHNAAGLITRLRHPVSPDGSSAQQVSAPF 328

Query: 110 ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
           E  +WEL  +++ L +++G G FG V +G   K   A            +   M+++ ++
Sbjct: 329 EADQWELNPDELTLGQEIGSGQFGLVLEGWWKKKKVAVK--------MIRDGCMSEDDLQ 380

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--KLHFPMIKKYE 227
           E   EAR+M  L H  +V+ + V++   PL ++ E  + G L   L   K          
Sbjct: 381 E---EARVMMKLSHHKLVQLYAVSSQRSPLCLVFEFMENGCLSDYLRARKGSLSQETLLN 437

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +    + G+AY+   N +HRD+AARNCL      +
Sbjct: 438 MCMDVSEGMAYLESSNFLHRDLAARNCLVSENNEV 472


>UniRef50_A8XFQ1 Putative uncharacterized protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8XFQ1_CAEBR
          Length = 643

 Score =  259 bits (663), Expect = 6e-68,   Method: Composition-based stats.
 Identities = 90/299 (30%), Positives = 142/299 (47%), Gaps = 44/299 (14%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEP------------------------ 38
           ++ +     +HG + RED+  +L   G +L+R S                          
Sbjct: 215 EEHICKMPNFHGYICREDVTILLKNSGDWLVRLSVQPCKENEKKASKGAKSVERGSKARG 274

Query: 39  ----VKGEKRQFVLSVVGE-----KKTSANHFVVRESDHKVYVDKIG-FPTIIELVNHYV 88
                K   + FV+SV         K+S  + V++ +D K  +D I  F  + +  ++Y 
Sbjct: 275 SKNRSKDNNKVFVISVHSRKAVSPGKSSCRNLVIKTNDGKFSIDSIKWFMKVADFFSYYQ 334

Query: 89  STKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT-KKLGEGAFGEVWKGKLL-KILDA 146
            T  ++       +  L        WE + +D+EL  KKLGEGAFG+V  G++  K    
Sbjct: 335 GTVATYK----ESEFQLLHPCHLSVWEFHQDDIELMSKKLGEGAFGDVRVGRMTTKDPKK 390

Query: 147 NHQPVLVAVKTAKL--ESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIME 204
               V VAVK  K   ES+T++Q+ E++ EAR+MR LDH NV++ +GV+   EPLY++ E
Sbjct: 391 TVAVVDVAVKMLKNSLESITRDQVDELLHEARVMRRLDHPNVLRTYGVSVLREPLYLMNE 450

Query: 205 LADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
           L   GAL   L + H    +  K   +  AA G+AY+H + ++HRD+A RN        
Sbjct: 451 LCANGALREYLKENHKTITISDKLNFVLGAARGVAYLHSQRIIHRDLAVRNVFLTENMT 509


>UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C5J9R9_SCHMA
          Length = 565

 Score =  259 bits (663), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 65/269 (24%), Positives = 106/269 (39%), Gaps = 34/269 (12%)

Query: 11  YYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS----ANHFV 62
           +Y   + R +    L    N  G +L+R S     E + + LSV             H+ 
Sbjct: 181 WY--NIGRREADRKLLLVGNPQGTYLIRPSS----ETQNYALSVRHYDSEKNMWVVKHYR 234

Query: 63  VRESDH--KVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKW-ELYH 118
           +R  D+    ++  +  FP I +LVN+Y    +    +         +         +  
Sbjct: 235 IRILDNNGGFFISIRTTFPNIQDLVNYYTVHPDGLCCRLSIPCPRAYRPPVHFVMFAIIR 294

Query: 119 EDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
           + +   +KLG+G FGEV+  K           V VAVK      +        + EARLM
Sbjct: 295 DSITRIRKLGQGTFGEVYLAKWNG-------SVEVAVKM----RLDPTDRSRFIEEARLM 343

Query: 179 RNLDHINVVKFFGVAAGTE--PLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAA 233
               H  +V+  GV    E  P+Y+I EL    AL   L         +    +++ Q A
Sbjct: 344 HAFHHPRIVQLLGVCTEPEDQPVYIITELMRKXALYDFLRTEEGHKLTLDDLIDIMAQIA 403

Query: 234 NGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +G++Y+   N +HRD+ A N L      +
Sbjct: 404 SGMSYLEXMNSVHRDLRAANILVDQDYSV 432


>UniRef50_A8Q767 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q767_BRUMA
          Length = 500

 Score =  258 bits (660), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 100/277 (36%), Positives = 148/277 (53%), Gaps = 24/277 (8%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS---AN 59
            K +L + YYHG LPRED+  +L + G F++R ++    +  + +LS+    + S     
Sbjct: 19  PKKVLDESYYHGFLPREDLPCLLEQVGDFIIRITQLKPRDPCELILSLRVSDQNSPSAIR 78

Query: 60  HFVVRESDHK------VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK 113
           H V+     K      +   +  F ++ EL++ YVS+K+          + L + + RQ 
Sbjct: 79  HVVIHRLKGKDGKIEWLTNQENRFNSLKELIDAYVSSKKPI--NPEIKTSQLIRPIARQS 136

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVK---TAKLESM---TKEQ 167
           WE  HE++ L   LGEG FGEV  G+ +     + + + VAVK   T K +      KE+
Sbjct: 137 WEFLHENIILKDMLGEGQFGEVRAGEAI----IDGKKIPVAVKIAKTIKDKKNIQQAKEK 192

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKK 225
           IKE+M EARLMR  DH NVVK  GVA   EPL +I+EL +GG L   L   K +    +K
Sbjct: 193 IKEMMHEARLMRYFDHENVVKIHGVAVCREPLMIIIELVNGGCLSDVLESRKGNIDEDEK 252

Query: 226 Y-ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
              +   +A GL YIH + ++HRD+AARN LY   +V
Sbjct: 253 IENMSLGSARGLEYIHAQRIIHRDIAARNVLYTENRV 289


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score =  258 bits (660), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 59/271 (21%), Positives = 107/271 (39%), Gaps = 25/271 (9%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNK---PGQFLLRTSEPVKGEKRQFVLSVVGEKKTS 57
           +T  DL   +++   + R   +++L +    G FL+R S  V          +  E    
Sbjct: 251 LTRFDLEQNRWFCKDITRAKAEQLLRQAGSEGSFLVRESSQVGKLTVSVYSCIPCE---V 307

Query: 58  ANHFVVRESDHK--VYVDKIGFPTIIELVNHYVSTKESFSTKDGTV-----KAVLKQAVE 110
             H+ V++         +K  F TI +L++++        T+         +      + 
Sbjct: 308 VKHYHVKQLPTGEWYLAEKHTFSTISDLIHYHQHNAAGLVTRLRHPVRPGEELPSTAGLS 367

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
             KWEL   ++   ++LG GA G V  G    +         +A++      + ++   +
Sbjct: 368 YGKWELDALELTSLRELGRGALGVVQLGMWRGVR-------HIAIRMLHEGVLAED---D 417

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYEL 228
              E +LM  L H N+V+ +GV     PL ++ME    G L + L             E 
Sbjct: 418 FFHEVKLMMQLSHPNLVQLYGVVTRYRPLRIVMEYLALGCLRTFLQARPGKLGSAWLLEA 477

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
                  + Y+   + +HRD+AAR+CL G  
Sbjct: 478 CSDVCKAMVYLESNSFLHRDLAARHCLVGED 508


>UniRef50_A8PJL3 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8PJL3_BRUMA
          Length = 668

 Score =  258 bits (659), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 108/256 (42%), Positives = 147/256 (57%), Gaps = 13/256 (5%)

Query: 10  KYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN-HFVVRESDH 68
            Y+HG LPRED   +    G FLLRT+E   GE R+  LSV    K     H+   +  +
Sbjct: 242 DYFHGFLPREDANMLCILDGDFLLRTTEVFSGEDRKLCLSVAWHGKHHIILHY--DKLKN 299

Query: 69  KVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKL 127
           +  +     FPTI +LVN+Y   +     +    + +LK  +  Q WEL H+ ++L +KL
Sbjct: 300 RYGIKPSRTFPTITDLVNYYAQHRFKILKE----RVLLKNPIVTQSWELKHQQLQLLQKL 355

Query: 128 GEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVV 187
           GEGAFGEV    L      +   V  AVK  K ++MTKE+++E M E R++RNL H N+V
Sbjct: 356 GEGAFGEVHSANLALTPRFH---VKAAVKVLKCDAMTKEKVREAMCEVRMLRNLRHENIV 412

Query: 188 KFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELIYQAANGLAYIHEKNLM 245
           +F+GVA   EPL ++MEL   GALD  L K   +  M  K  +I  AA GLAY+H +N+M
Sbjct: 413 RFYGVANRKEPLMIVMELVKEGALDVFLRKNGNNLSMKNKLLMIRDAAFGLAYLHSQNIM 472

Query: 246 HRDVAARNCLYGGGQV 261
           HRD+A RNCLY G  V
Sbjct: 473 HRDLATRNCLYTGEIV 488


>UniRef50_A8Q7I8 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q7I8_BRUMA
          Length = 375

 Score =  257 bits (657), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 85/272 (31%), Positives = 137/272 (50%), Gaps = 31/272 (11%)

Query: 3   DKDLL-----HQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTS 57
           D  +       + +YHG LP  DI  +L + G F++R +     +K    LS +   K  
Sbjct: 2   DDSIELNNELQRTFYHGFLPHADIDPLLKEEGDFVIRKT-----DKDGNHLSKIYNWK-- 54

Query: 58  ANHFVVRESDHKVYVDKIGF------PTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER 111
               ++ +S    +     F       T+ +L+N + +T    S       A L   V R
Sbjct: 55  ----IIFQSAQNNFFCSCYFYCLQDEKTMHDLINWHKTTGTPISAGSH---AKLVNGVGR 107

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
           Q W L H++++L +KLGEGAFGEV+  + +++    ++   VAVKT + E+ +++   + 
Sbjct: 108 QPWLLEHDEIQLQRKLGEGAFGEVYLAQYVQM----NKITDVAVKTMREEA-SRQARLKF 162

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIY 230
           M+EAR+MR   H NVVK  G+     PL ++MEL   G++ S L K        K   + 
Sbjct: 163 MKEARIMRKFSHPNVVKIMGIVVYENPLMIVMELCPEGSMLSYLRKNVPVNSDLKLRFVT 222

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +A+ GLAY+  K+ +HRD+AARNCL      +
Sbjct: 223 EASAGLAYLESKHCIHRDIAARNCLLSEQLEV 254


>UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase n=36
           Tax=Euteleostomi RepID=MATK_HUMAN
          Length = 507

 Score =  256 bits (656), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 70/271 (25%), Positives = 115/271 (42%), Gaps = 29/271 (10%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
            D  L    ++HG +  ++  + L   + G FL+R S    G+   +VL V         
Sbjct: 113 ADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGD---YVLCVSF--GRDVI 167

Query: 60  HFVVRESDHKVYVDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK----- 113
           H+ V   D  + +D+ + F  ++++V HY   K +  TK    K         ++     
Sbjct: 168 HYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAG 227

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           W L  + + L  ++GEG FG V +G+ L           VAVK  K +   +      + 
Sbjct: 228 WLLNLQHLTLGAQIGEGEFGAVLQGEYLGQ--------KVAVKNIKCDVTAQA----FLD 275

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG---KLHFPMIKKYELIY 230
           E  +M  + H N+V+  GV      LY++ME    G L + L    +      +  +   
Sbjct: 276 ETAVMTKMQHENLVRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSL 334

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
             A G+ Y+  K L+HRD+AARN L     V
Sbjct: 335 HVAEGMEYLESKKLVHRDLAARNILVSEDLV 365


>UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia malayi
           RepID=A8Q5B5_BRUMA
          Length = 1138

 Score =  255 bits (652), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 86/272 (31%), Positives = 134/272 (49%), Gaps = 21/272 (7%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
             K+L  Q +YHGLL REDI+++L K G FL+R ++       Q VLS+         H 
Sbjct: 714 QRKELEDQHWYHGLLSREDIEKLLVKNGDFLVRVTDNQG--VHQIVLSI--HVGERNIHL 769

Query: 62  VVRESDHKVYV-----DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL 116
            +  ++   +          FP+I +LV +Y   K       G     L   V + KW +
Sbjct: 770 TIAVTEDGHFQLSVLRRGPRFPSIYDLVQYYKMHKIKIKDASGKD-IRLGDGVPKPKWLV 828

Query: 117 YHEDVELTK--------KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLE-SMTKEQ 167
            HE +   K         LG G F +V+ G      D N Q + VA+K  K E    +E 
Sbjct: 829 KHEAINYDKNKACHLNLPLGSGNFADVYLGTFTCEKDGNKQIIPVAIKIIKPEKGGGREA 888

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKK 225
            + ++RE ++M   +H N+V+F+GVA    P+ ++ME   GG+L++ L K      + ++
Sbjct: 889 KQSMIREGKIMSFYNHENIVQFYGVACDRPPIAIVMEYCPGGSLENHLKKQKENIVIGER 948

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
            E   +AA G+ Y+H +  +HRD+AARNCL  
Sbjct: 949 IEYCLEAALGMRYLHMQGCLHRDLAARNCLIS 980


>UniRef50_Q22765 Protein T25B9.4, partially confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=Q22765_CAEEL
          Length = 546

 Score =  254 bits (651), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 94/274 (34%), Positives = 155/274 (56%), Gaps = 21/274 (7%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKG--EKRQFVLSVVGEKKT--- 56
           T K L++QK+YHG LPRED+  +L K G F+ R +E   G  +K+  VLS+    ++   
Sbjct: 7   TFKWLMNQKFYHGYLPREDLPYVLKKKGDFIFRVTERTVGKEQKKDIVLSIAWPTESVAM 66

Query: 57  ----SANHFVVRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER 111
                  ++++  S + V++D KI F +I  L NHY   +         ++  L + +  
Sbjct: 67  IDTKDIKNYLIERSANSVWLDLKISFHSIDALYNHYRKNELVH----PNLRIKLGRPICL 122

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLE-SMTKEQIKE 170
             WE  H  + L KK+G+GA+GEV+KG + +     +     A+K  + +     E++KE
Sbjct: 123 FFWEFKHSQINLIKKVGKGAYGEVFKGTVTRGNKTFNG----AIKAMRKDLDAGNEKMKE 178

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYEL 228
           +M EARLMR+L+H N+V+  G+A   +P+Y+++E  +GG LDS L K      M +K  +
Sbjct: 179 VMAEARLMRSLNHPNIVRCRGIAVLEQPVYIVIEFINGGGLDSYLKKNSQTLTMDQKNRM 238

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              AA G+ ++H  +++HRD+AARNCLY    ++
Sbjct: 239 AISAAWGIEFMHSHDIIHRDIAARNCLYDNKNLV 272


>UniRef50_A8QBK0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QBK0_BRUMA
          Length = 442

 Score =  252 bits (645), Expect = 8e-66,   Method: Composition-based stats.
 Identities = 87/260 (33%), Positives = 137/260 (52%), Gaps = 12/260 (4%)

Query: 2   TDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHF 61
            + +LL + YYHG++   D++++L + G FL     P + E+   V  V   +   A + 
Sbjct: 63  ANDNLLSETYYHGIVNCVDVEKLLIRDGDFLF--GIPEEDEEESIVWVVRYNRDLWAFNI 120

Query: 62  VVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDV 121
            + E D   +V++  F  I E+V+ Y+ T++           V+K+ V    W + H+ V
Sbjct: 121 GLTEKD-LYFVNQKCFKKISEMVSDYIRTRKPIHETL---PIVVKRPVPHPAWVVSHDRV 176

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
            L  +LGEGAFG V+KG L       H  + VA KT   ++  K +    ++EA++MR+ 
Sbjct: 177 RLKDELGEGAFGRVYKGIL----QVGHTYMTVAAKTCVGQASDKTKRASFLQEAKVMRDY 232

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYI 239
            H N+V+F G+A   EPL +I+E   GG+L   L K   H  +  +Y    +A+ GL Y+
Sbjct: 233 KHENLVQFIGIACQKEPLMIIVEFCGGGSLLKYLRKKGAHLGIATRYRFGKEASAGLKYL 292

Query: 240 HEKNLMHRDVAARNCLYGGG 259
            EK  +HRDVAARNCL    
Sbjct: 293 EEKRCIHRDVAARNCLLTEH 312


>UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n=1 Tax=Ciona intestinalis
           RepID=UPI000180C4D7
          Length = 525

 Score =  251 bits (643), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 68/266 (25%), Positives = 114/266 (42%), Gaps = 26/266 (9%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           +  +  ++++ G    ++ + ML   KPG +++  S+   G  R   L++         H
Sbjct: 146 EDSIECERWFFGKKSEKECERMLVQQKPGTYMITESKTEPGIYR-ISLTIQEALTLLVKH 204

Query: 61  FVV-RESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHE 119
             +    D      K  F     + N+    +     K G  +      +    WE+  E
Sbjct: 205 QTIPLPHDRHHKHHKQAF-----IGNYIGRAQRGSIMKYGEHEKPETSGIAPGDWEIGRE 259

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
            +   KKLG GAFGEVWKG              VA+K  +  +M+ E     ++EA +MR
Sbjct: 260 HLTQQKKLGAGAFGEVWKG---------GFHQDVAIKELQPCTMSPEA---FLQEAEIMR 307

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYELIYQAANGL 236
            L H N+V  + V    EP+ ++ E    G+L   L       FP +   ++  Q A G+
Sbjct: 308 KLRHPNIVSIYAVIT--EPINIVTEFMCHGSLLDYLKDGPGSFFPFVDLIDMAAQIAAGM 365

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQVL 262
           A+I ++  +HRD+ A N L G  +V 
Sbjct: 366 AFIEQEKYIHRDLRADNVLVGENRVC 391


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 64/245 (26%), Positives = 105/245 (42%), Gaps = 27/245 (11%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVG--EK 54
           +    +  + ++   + R +    L    N  G FL+R SE   G    + LS+      
Sbjct: 106 IAMSTMETEAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPG---SYSLSMRDFDNN 162

Query: 55  KTSANHFVVRESDHK--VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVK--AVLKQAVE 110
                H+ +R  D+       KI F ++ ELV HY    +   TK          ++   
Sbjct: 163 GDGVKHYRIRNMDNGGFYITTKISFNSLKELVQHYSRDSDGLCTKLVKPCQSKAPQKPWW 222

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
           + +WE+  E ++L +KLG G FGEVW G         +    VA+K  K+ +M+ E    
Sbjct: 223 QDEWEIPRESLKLERKLGAGQFGEVWMGVY-------NNERRVAIKCLKIGTMSVEA--- 272

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---FPMIKKYE 227
            + EA +M+NL H  +V+ F V    EP+Y++ E  + G+L   L         M    +
Sbjct: 273 FLAEANMMKNLQHARLVRLFAVVTQ-EPIYIVTEYMENGSLVDYLKTTEGSSLSMNTLID 331

Query: 228 LIYQA 232
           +  QA
Sbjct: 332 MASQA 336


>UniRef50_B4DSE0 Ephrin receptor n=19 Tax=Euteleostomi RepID=B4DSE0_HUMAN
          Length = 928

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 64/221 (28%), Positives = 102/221 (46%), Gaps = 15/221 (6%)

Query: 47  VLSVVGEKKTSANHFVVRES---DHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKA 103
            ++V G K  +   F VR      +  Y  K+ F T+ E+      T       D     
Sbjct: 492 TVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEV------TPGMKIYIDPFTYE 545

Query: 104 VLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESM 163
              +AV     E+    V++ + +G G FGEV  G L        + + VA+KT K    
Sbjct: 546 DPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKL---PGKREIFVAIKTLKSG-Y 601

Query: 164 TKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFP 221
           T++Q ++ + EA +M   DH NV+   GV   + P+ +I E  + G+LDS L +    F 
Sbjct: 602 TEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT 661

Query: 222 MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +I+   ++   A G+ Y+ + N +HRD+AARN L     V 
Sbjct: 662 VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVC 702


>UniRef50_C4Q0E9 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4Q0E9_SCHMA
          Length = 1057

 Score =  251 bits (641), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 53/204 (25%), Positives = 85/204 (41%), Gaps = 19/204 (9%)

Query: 69  KVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAV-------LKQAVERQKWELYHEDV 121
              ++   F ++ +LV+H+    +  +                L+        E+   ++
Sbjct: 2   YYVIESNKFTSVSDLVHHHEKHSDGLACTLLYPAPKRDRTSSELRMDPSFDIREIDRTEI 61

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
            +  KLG G +G V++             VLVAVKT K     ++   E + EARLM++L
Sbjct: 62  VMKHKLGSGQYGVVYEAVWKPYN------VLVAVKTLKENVTVRD---EFLEEARLMKSL 112

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---HFPMIKKYELIYQAANGLAY 238
            H N+V   G      P Y++ E    G L   L               +  Q A G+AY
Sbjct: 113 RHPNLVTLLGACTREPPYYIVTEFMCNGNLLDYLRTHPRTELTPSVLLHMATQVARGMAY 172

Query: 239 IHEKNLMHRDVAARNCLYGGGQVL 262
           + + N +HRD+AARNCL G    +
Sbjct: 173 LEQHNFIHRDLAARNCLVGTQHTI 196


>UniRef50_UPI0001757DA5 PREDICTED: similar to insulin receptor, partial n=1 Tax=Tribolium
            castaneum RepID=UPI0001757DA5
          Length = 1450

 Score =  249 bits (636), Expect = 9e-65,   Method: Composition-based stats.
 Identities = 63/259 (24%), Positives = 108/259 (41%), Gaps = 35/259 (13%)

Query: 27   KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIGFPTIIELVN- 85
             PG + +R S    G+   F             +F + E     YV  I    I+ ++  
Sbjct: 985  SPGNYSVRVSATTSGDYANFS---------PYAYFYIEERPSNTYVTLIVCMLILVIILA 1035

Query: 86   -----HYVSTK---ESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWK 137
                  Y   K   ES           +       +WE+  + +EL ++LG+G+FG V++
Sbjct: 1036 LCAFCFYKKKKADKESMRLIPSVNPEYVPSVYVPDEWEVPRKKIELIRELGQGSFGMVYE 1095

Query: 138  GKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE 197
            G    +       +  AVKT    +  +E++ E + EA +M+  D  +VV+  GV +  +
Sbjct: 1096 GIAQDVR--GKAQIKCAVKTVNEHATNRERL-EFLNEASVMKAFDTAHVVRLLGVVSQGQ 1152

Query: 198  PLYVIMELADGGALDSALGKLH--------------FPMIKKYELIYQAANGLAYIHEKN 243
            P  VIMEL   G L + L                    + +  ++  + A+G+AY+  K 
Sbjct: 1153 PTLVIMELMANGDLKTYLRSHRPDAEVYDPATAKQPPTLKQILQMAIEIADGMAYLSAKK 1212

Query: 244  LMHRDVAARNCLYGGGQVL 262
             +HRD+AARNC+      +
Sbjct: 1213 FVHRDLAARNCMVAEDLTV 1231


>UniRef50_Q9U3B5 Protein K09B11.5a, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q9U3B5_CAEEL
          Length = 589

 Score =  249 bits (636), Expect = 9e-65,   Method: Composition-based stats.
 Identities = 75/256 (29%), Positives = 124/256 (48%), Gaps = 15/256 (5%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           L    +YHG++  + ++++L     +L+R +   +  K+   LSV  + K    HF +  
Sbjct: 71  LKFYPWYHGMMFGQTVEKLLKWDYAYLVRRA-MQRNSKKVLCLSVKIDGKIC--HFTLNS 127

Query: 66  SDHKVYVDK--IGFPTI-IELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           +       K    FP I  +   H     +++S    ++  V ++ +      L H  + 
Sbjct: 128 NKDGWSCGKLLAKFPKITPKRFQHIHHLLDAWSLVVNSIVPVPRRQLV-----LQHNCIH 182

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
           L   LG GAFGEV K + +     N   V VAVK   + +  +EQ++E   EA++M  L 
Sbjct: 183 LENILGNGAFGEVLKARYIPRGHTNG--VEVAVKRV-IGTAQREQMQEFCHEAQIMGTLK 239

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIHE 241
           H NVVK +G+A+  +P+ ++MEL  GG L   L      P  +        ANG+ ++  
Sbjct: 240 HDNVVKLYGIASLEQPIMLVMELITGGDLKKYLQSTPSIPNRQLIAFALDIANGMRHLVI 299

Query: 242 KNLMHRDVAARNCLYG 257
           K ++HRD+AARNCL  
Sbjct: 300 KKVIHRDLAARNCLIS 315


>UniRef50_Q21299 Protein W08D2.8, partially confirmed by transcript evidence n=2
           Tax=Caenorhabditis RepID=Q21299_CAEEL
          Length = 543

 Score =  247 bits (632), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 68/260 (26%), Positives = 117/260 (45%), Gaps = 14/260 (5%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           LL + +YHG++  +  +++L     +++R S    G   +F L +    +    HF    
Sbjct: 67  LLQRNWYHGMMFGKAAEKLLKWESSYIVRRS---MGPTHKF-LCITARVEDKYFHFQFNW 122

Query: 66  SDHKVYVDK--IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
           +            FP I   V  Y    +        V  ++   + R    L H  + L
Sbjct: 123 NSEGWSCPILYEKFPRIP--VKRYEHIYQLLDAWSLVVNQLV--PISRCSMILQHSSIAL 178

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
             +LG GAFGEV K K   +      P  VAVK   +    + Q+ +   EA +M  L+H
Sbjct: 179 ENQLGRGAFGEVIKAKY--VPMGATVPTEVAVKRL-IGDAKRPQLVDFCNEANIMTLLEH 235

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIHEK 242
            N+V  +G A+  +P+ +++E   GG L   L +  + P  +  +   + A+G+ ++  K
Sbjct: 236 KNIVALYGFASLQQPIMLVIEFVPGGDLRKYLQRTPNVPSKQIIKFAMEIASGMKHLSSK 295

Query: 243 NLMHRDVAARNCLYGGGQVL 262
           N++HRD+AARNCL      +
Sbjct: 296 NVIHRDLAARNCLITKELNV 315


>UniRef50_A8NEQ9 Protein kinase domain containing protein (Fragment) n=1 Tax=Brugia
           malayi RepID=A8NEQ9_BRUMA
          Length = 293

 Score =  247 bits (632), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 100/205 (48%), Positives = 138/205 (67%), Gaps = 7/205 (3%)

Query: 58  ANHFVVRESDHK-VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL 116
             H+V++ + +    ++K GF ++ E++N +++  ES        +  L   + RQ WEL
Sbjct: 1   IKHYVIQRTPNGKYTIEKYGFDSVPEMINFHLNKHESLVK---NAEVFLTTPILRQTWEL 57

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
           +HEDVE TKKLGEGAFGEV  G+L      N + V VA+K AKLE++TKEQIKEIM+EAR
Sbjct: 58  HHEDVEPTKKLGEGAFGEVHLGRLRLR---NGRKVDVAIKLAKLEALTKEQIKEIMKEAR 114

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGL 236
           L R  DH NV K +GVAAG EPL ++MELA+ GALDS L K H  + +K ++   A+ GL
Sbjct: 115 LHRTFDHPNVCKCYGVAAGQEPLMIVMELANKGALDSYLQKNHVSVEQKMDMCLGASWGL 174

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQV 261
            Y+H K ++HRD+AARNCL+G  +V
Sbjct: 175 EYLHAKPVLHRDIAARNCLFGDNKV 199


>UniRef50_Q9XW34 Protein Y69E1A.3, partially confirmed by transcript evidence n=4
           Tax=Caenorhabditis elegans RepID=Q9XW34_CAEEL
          Length = 563

 Score =  247 bits (632), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 71/252 (28%), Positives = 119/252 (47%), Gaps = 13/252 (5%)

Query: 12  YHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVY 71
           YHG+L   + +++L     +L+R +     +     L +    K    H+ +  ++    
Sbjct: 95  YHGVLFGSEAEKLLTWDRAYLVRRAITKPNK----FLCISVNWKNKIFHYQLDFNEDGWC 150

Query: 72  VDK--IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
             K    FPT+      ++  ++           ++     R    L H  + L KKLG 
Sbjct: 151 CKKLYEKFPTMPN--RRFLHIRQLLEAWSQATPFLI--PTPRGSNVLIHSTINLDKKLGC 206

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           GAFGEV+KG+   +    + P+ VAVK   L +  ++QI+E   EA++M  L H N+V F
Sbjct: 207 GAFGEVFKGQYKAVGST-NPPIEVAVKRI-LGNAKRKQIQEFCNEAQIMTVLQHENIVAF 264

Query: 190 FGVAAGTEPLYVIMELADGGALDSALG-KLHFPMIKKYELIYQAANGLAYIHEKNLMHRD 248
           +G A+  EP+ V+MEL  GG L        + P ++        A+G+ ++  K ++HRD
Sbjct: 265 YGFASLEEPIMVVMELVTGGDLRKYFQTTQNIPKLQILWFAMNVASGMRHLSSKGIIHRD 324

Query: 249 VAARNCLYGGGQ 260
           +AARNCL     
Sbjct: 325 LAARNCLVTQDL 336


>UniRef50_A8WSQ7 Putative uncharacterized protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8WSQ7_CAEBR
          Length = 481

 Score =  246 bits (628), Expect = 8e-64,   Method: Composition-based stats.
 Identities = 84/312 (26%), Positives = 138/312 (44%), Gaps = 56/312 (17%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQF-------------- 46
           M + +LL   ++HG + +E    +L   G +++R S   + + +                
Sbjct: 26  MIENNLLRYPFFHGFVLQELQLMLLKTNGDYIMRLSHQPEKKAKSIGAKKASAEKTGPVD 85

Query: 47  ---------VLSV------------------VGEKKTSANHFVVRESDHK---VYVDKI- 75
                    VLSV                  V +K+    H  + E + K    +V++  
Sbjct: 86  QSTLTRVILVLSVNITQKPDNTRSFYGDLDEVKQKENMDMHVCIEEINGKWVSFFVERRT 145

Query: 76  GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTK--KLGEGAFG 133
            F +I +L+ +Y +    +       +  LK+ +  Q WEL  + +E+ K  KLGEGA+G
Sbjct: 146 KFASIDDLITYYRTNPICYQA----TRVFLKRPIPLQDWELRKDGLEVIKTKKLGEGAYG 201

Query: 134 EVWKGKLLKILDAN----HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           EV+ GK  +    +    H+   VAVK  K +  ++  + EIM EARL   L H NV+ F
Sbjct: 202 EVYLGKWAQPFSVDQKEFHKWCDVAVKMLKKDD-SRAALFEIMHEARLQLQLRHKNVLAF 260

Query: 190 FGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
            GV    +P+ ++ E  + G+L   L K    +  K      ++ GL YIH K L+HRD+
Sbjct: 261 RGVFLLKKPIMLVSEFCENGSLKDYLQKNKVGVDDKLRFCLGSSCGLEYIHFKGLIHRDL 320

Query: 250 AARNCLYGGGQV 261
           A RN L    + 
Sbjct: 321 ATRNILVSLDKT 332


>UniRef50_Q4RVA1 Chromosome 15 SCAF14992, whole genome shotgun sequence n=1
           Tax=Tetraodon nigroviridis RepID=Q4RVA1_TETNG
          Length = 885

 Score =  245 bits (626), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 52/180 (28%), Positives = 90/180 (50%), Gaps = 6/180 (3%)

Query: 85  NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKIL 144
            H+  +       D        +AV     E+    V++ + +G G FGEV+KG+L    
Sbjct: 385 THFSGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSTVKIEEVIGAGEFGEVYKGRLKL-- 442

Query: 145 DANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIME 204
               + + VA+KT K   + ++Q ++ + EA +M   DH N+++  GV   + P+ ++ E
Sbjct: 443 -PGKREIYVAIKTLKSGYV-EKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTE 500

Query: 205 LADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + GALDS L +    F +I+   ++   + G+ Y+ E N +HRD+AARN L     V 
Sbjct: 501 FMENGALDSFLRQNDGQFTVIQLVGMMRGISAGMKYLSEMNYVHRDLAARNILVNSNLVC 560


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score =  245 bits (626), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 61/285 (21%), Positives = 106/285 (37%), Gaps = 45/285 (15%)

Query: 7   LHQKYYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVR 64
            +Q ++H ++ RE+ +++L     G FL+R S    G+   F L +    K    H+ + 
Sbjct: 144 NNQPWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGD---FTLCMAYHGK--VEHYRIE 198

Query: 65  ESDHK-VYVDKI-GFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ---------- 112
           ++    +  DK   F  + +LV+HY    +    +  T                      
Sbjct: 199 QTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSST 258

Query: 113 -KWE------------LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAK 159
              E            +   ++++   +G G FG+V  G              VA+K +K
Sbjct: 259 VDLEDRTSVFRHAGLVIPSNEIDVGDTIGHGEFGDVRLGTYKNR--------KVALKVSK 310

Query: 160 LESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--- 216
                   +  ++ EA+ M  L H N+V   GV      +Y+I E    G L   L    
Sbjct: 311 RHG--NGMLDSLLDEAKFMVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRG 368

Query: 217 KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
           +      +          G+ Y+  K ++HRD+AARN L     V
Sbjct: 369 RHALERRQLMMFAIDICQGMCYLESKQIVHRDLAARNVLLDEDLV 413


>UniRef50_UPI000194BA20 PREDICTED: EPH receptor A3 n=2 Tax=Euteleostomi RepID=UPI000194BA20
          Length = 1106

 Score =  243 bits (622), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 53/180 (29%), Positives = 92/180 (51%), Gaps = 6/180 (3%)

Query: 85  NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKIL 144
           N ++      +  D        QAV     EL   ++ + K +G G FGEV  G+L    
Sbjct: 708 NGHLKLPGLRTYVDPHTYEDPNQAVHEFAKELDASNISIDKVVGAGEFGEVCSGRLKL-- 765

Query: 145 DANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIME 204
             + + + VA+KT K+   T++Q ++ + EA +M   DH N+++  GV   ++P+ ++ E
Sbjct: 766 -PSKKEISVAIKTLKVG-YTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTE 823

Query: 205 LADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + G+LDS L K    F +I+   ++   A+G+ Y+ +   +HRD+AARN L     V 
Sbjct: 824 YMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVC 883


>UniRef50_Q6PFV6 Ephrin receptor n=8 Tax=Amniota RepID=Q6PFV6_MOUSE
          Length = 819

 Score =  243 bits (621), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 6/180 (3%)

Query: 85  NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKIL 144
           N ++      +  D        QAV     E+    + + + +G G FGEV  G+L    
Sbjct: 455 NGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKL-- 512

Query: 145 DANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIME 204
               + + VA+KT K+   T++Q ++ + EA +M   DH N++   GV   ++P+ ++ E
Sbjct: 513 -PGKRELPVAIKTLKVG-YTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTE 570

Query: 205 LADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + G+LD+ L K    F +I+   ++   A G+ Y+ +   +HRD+AARN L     V 
Sbjct: 571 YMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVC 630


>UniRef50_UPI00005A03D8 PREDICTED: similar to Ephrin type-A receptor 2 precursor
           (Tyrosine-protein kinase receptor ECK) (Epithelial cell
           kinase) isoform 5 n=2 Tax=Euteleostomi
           RepID=UPI00005A03D8
          Length = 819

 Score =  242 bits (619), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 56/179 (31%), Positives = 87/179 (48%), Gaps = 6/179 (3%)

Query: 86  HYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILD 145
           HY   K   +  D        QAV +   E++   V   K +G G FGEV+KG L     
Sbjct: 422 HYGQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGTLKAS-- 479

Query: 146 ANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMEL 205
              + V VA+KT K    T++Q  + + EA +M    H N+++  GV +  +P+ +I E 
Sbjct: 480 -GKKEVPVAIKTLKAG-YTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEY 537

Query: 206 ADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + GALD  L +    F +++   ++   A G+ Y+   N +HRD+AARN L     V 
Sbjct: 538 MENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVC 596


>UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine kinase n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793830
          Length = 686

 Score =  242 bits (619), Expect = 8e-63,   Method: Composition-based stats.
 Identities = 64/272 (23%), Positives = 118/272 (43%), Gaps = 36/272 (13%)

Query: 11  YYHGLLPREDIQEMLNK---PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESD 67
           +YHG L R +   +L      G FL+R        +  +VLS++   +    HF +++ D
Sbjct: 290 WYHGKLDRHEATAILKTKDVDGCFLVRM-----NRQSGYVLSMMCTNQ--CYHFQIQDRD 342

Query: 68  HKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTV-------------KAVLKQAVERQK 113
              ++D      ++  L+ HY    +    K                    LK+   + +
Sbjct: 343 KYYFIDNGPYLNSLEHLIQHYTLFPDGLPNKLEVPVSPAVIPPLPKGFPFTLKKPKPKHQ 402

Query: 114 WE----LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
            E    +  +++ L + +GEG FG V+KG        +     VA+K  + + M+     
Sbjct: 403 TEFQDNIMRDNLILDEVIGEGEFGSVYKGTFQNR---DGFEEKVAIKMLRYD-MSSTNKS 458

Query: 170 EIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHF---PMIKKY 226
           E +REA +M +L+H  +++  G+     PL ++ EL   G++ + +        P  +  
Sbjct: 459 EFLREAHVMMSLNHECIIRLIGIC-EGPPLLMVQELIALGSMLTHIITHPELISPNYELK 517

Query: 227 ELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
               Q A+G+ Y+ +K  +HRD+AARN L   
Sbjct: 518 MWAAQIASGMCYLEQKRFVHRDLAARNILLAD 549



 Score = 73.1 bits (179), Expect = 9e-12,   Method: Composition-based stats.
 Identities = 22/110 (20%), Positives = 43/110 (39%), Gaps = 14/110 (12%)

Query: 11  YYHGLLPREDIQEML-----NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           +YHG + R+  + +L      + G FL+R S    G+   +VL V+   +    H+ +R 
Sbjct: 12  WYHGKISRDTAEIILLDHESKEDGLFLVRESNSASGD---YVLCVLQNNE--VVHYQIRR 66

Query: 66  SDHKVYV---DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ 112
                +    ++     +  L+ HY    +  S      K ++K      
Sbjct: 67  HGEDAFFSIDEQNIMHGLETLIEHYCKVNDP-SLGVQLSKPIVKDPPPHD 115


>UniRef50_P29323 Ephrin type-B receptor 2 n=364 Tax=Eumetazoa RepID=EPHB2_HUMAN
          Length = 1055

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 56/184 (30%), Positives = 88/184 (47%), Gaps = 9/184 (4%)

Query: 84  VNHYVS---TKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKL 140
           + HY S   T       D        +AV     E+    V++ + +G G FGEV  G L
Sbjct: 581 LQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHL 640

Query: 141 LKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLY 200
                   + + VA+KT K    T++Q ++ + EA +M   DH NV+   GV   + P+ 
Sbjct: 641 KL---PGKREIFVAIKTLKSG-YTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVM 696

Query: 201 VIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           +I E  + G+LDS L +    F +I+   ++   A G+ Y+ + N +HRD+AARN L   
Sbjct: 697 IITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS 756

Query: 259 GQVL 262
             V 
Sbjct: 757 NLVC 760


>UniRef50_P54756 Ephrin type-A receptor 5 n=102 Tax=Euteleostomi RepID=EPHA5_HUMAN
          Length = 1037

 Score =  241 bits (615), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 49/180 (27%), Positives = 88/180 (48%), Gaps = 6/180 (3%)

Query: 85  NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKIL 144
           N ++      +  D        QAV     E+    + + + +G G FGEV  G+L    
Sbjct: 639 NGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKL-- 696

Query: 145 DANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIME 204
               + + VA+KT K+   T++Q ++ + EA +M   DH N++   GV   ++P+ ++ E
Sbjct: 697 -PGKRELPVAIKTLKVG-YTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTE 754

Query: 205 LADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + G+LD+ L K    F +I+   ++   + G+ Y+ +   +HRD+AARN L     V 
Sbjct: 755 YMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVC 814


>UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine kinase n=3 Tax=Hydra
           magnipapillata RepID=UPI0001925EBD
          Length = 730

 Score =  240 bits (614), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 72/267 (26%), Positives = 125/267 (46%), Gaps = 27/267 (10%)

Query: 4   KDLLHQKYYHGLLPREDIQ-EMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
             L    +Y G++ R      +L+    G FL+R S    G+   + LS+    +TS  H
Sbjct: 93  DYLKKYDWYTGVMGRSSANLALLSNGSAGSFLVRKSTSKPGD---YTLSL--HNETSLKH 147

Query: 61  FVVRESDHK-VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHE 119
           + ++++ +   Y+ K  F  +  LV HY               +      +++ W++ H 
Sbjct: 148 YHIKKTKNCTFYILKEEFSNLPSLVEHYKKVSGGLPRTLKDACS------QKKLWDIPHN 201

Query: 120 DVELTKK-LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLM 178
            + LTKK LG+G FG V +G+L          V VAVK  K ++  K +  + ++EA  M
Sbjct: 202 KITLTKKHLGKGNFGIVLEGRLF-------SSVNVAVKVLKTDNC-KMKETKFLKEANNM 253

Query: 179 RNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAANG 235
           + L H N++  +GV      +Y+++ELA  GAL   L      +  +     +  Q ++G
Sbjct: 254 KELSHKNLIHCYGVCYFDSYVYIVLELALHGALHKFLQTSTGQNLTLHDLVHIATQISSG 313

Query: 236 LAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + ++    L+HRD+AARN L     V+
Sbjct: 314 MTHLSHIRLLHRDIAARNMLVASKMVI 340


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score =  240 bits (613), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 76/275 (27%), Positives = 123/275 (44%), Gaps = 30/275 (10%)

Query: 8   HQKYYHGLLPREDIQEMLN----KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
            Q ++HG + RE+ ++ +     + G FL+R       E   F L V    K    H+++
Sbjct: 160 KQLWFHGAISREESEQRMKAFGLRDGLFLVRERT----EVNSFALCVAV--KNDIYHYLL 213

Query: 64  RESD-HKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLK-------------QA 108
             +   ++ ++    F  ++++V+HY  T +        V AV +             + 
Sbjct: 214 EMNTLGQLSIENGRKFENLLQVVDHYSRTPDGLLCTLVDVCAVTRFEAQAVPMPGAVVKR 273

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
           V+     +   ++    +LG G FG V  G            V  A+K  K       Q 
Sbjct: 274 VKHGPRRIEDSELSTQGELGAGTFGTVRLGVYR--PKNGEPEVQCALKYLKQSEELPNQK 331

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-FPMIKKYE 227
            EI+REA  M  LDH N+V+ FG+    +P+ ++MELA  G L+  L K   FP+IK   
Sbjct: 332 AEILREADAMAALDHCNIVRLFGICV-GDPICLVMELARQGPLNKFLRKRPTFPVIKILN 390

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCL-YGGGQV 261
           +  Q + G+AY+ E   +HRD+AARN L      V
Sbjct: 391 MALQVSRGMAYLEEVRFVHRDLAARNVLVVDDDNV 425



 Score = 93.5 bits (232), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 29/125 (23%), Positives = 54/125 (43%), Gaps = 11/125 (8%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNK----PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           DL  + +YHG + R D +++L+      G FL+R S    GE   +VLS+  + K    H
Sbjct: 3   DLSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGE---YVLSLSFQGKK--YH 57

Query: 61  FVVRESDHKVYV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYH 118
           +++           D   F + IEL+ ++    +   T        L     +    + H
Sbjct: 58  YIISRHPDGSVAIQDGAKFDSPIELIQYHTKKVDGLITTLKQPCCRLPGQPPQGYRFISH 117

Query: 119 EDVEL 123
           E++++
Sbjct: 118 EEMQM 122


>UniRef50_Q07497 Ephrin type-B receptor 5 n=68 Tax=Euteleostomi RepID=EPHB5_CHICK
          Length = 1002

 Score =  239 bits (610), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 52/186 (27%), Positives = 90/186 (48%), Gaps = 8/186 (4%)

Query: 81  IELVNHYVSTKES--FSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKG 138
            + +  Y+ST+        D +      +A+     E+    +++ + +G G FGEV  G
Sbjct: 595 TDRLQQYISTRGLGVKYYIDPSTYEDPNEAIREFAKEIDVSFIKIEEVIGSGEFGEVCFG 654

Query: 139 KLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEP 198
           +L        +   VA+KT K    T EQ +E + EA +M   +H NV+   GV   + P
Sbjct: 655 RLK---HPGKREYTVAIKTLKSG-YTDEQRREFLSEASIMGQFEHPNVIHLEGVVTKSRP 710

Query: 199 LYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLY 256
           + ++ E  + G+LDS L +    F +++   ++   A G+ Y+ + N +HRD+AARN L 
Sbjct: 711 VMIVTEFMENGSLDSFLRQKEGQFSVLQLVGMLRGIAAGMRYLSDMNYVHRDLAARNILV 770

Query: 257 GGGQVL 262
               V 
Sbjct: 771 NSNLVC 776


>UniRef50_Q4SQX3 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SQX3_TETNG
          Length = 780

 Score =  239 bits (610), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 58/195 (29%), Positives = 93/195 (47%), Gaps = 10/195 (5%)

Query: 74  KIGFPTIIELVNHYVSTKESFS----TKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
              F    E   HY +   SF       D        QAV     E+    +++ K +G 
Sbjct: 364 SKAFQDSDEEKMHYQNGHVSFPDARFYIDPHTYEDPCQAVHEFAREIEASRIKIEKIIGS 423

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           G FGEV  G++        + + VA+KT K+   T++Q ++ + EA +M   DH NV++ 
Sbjct: 424 GEFGEVCYGRMRL---PGKRDIPVALKTLKVG-YTEKQKRDFLAEASIMAQFDHPNVIRL 479

Query: 190 FGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHR 247
            GV   ++P+ +I E  + G+LDS L +    F +I+   L+   A G+ Y+ +   +HR
Sbjct: 480 EGVVTHSKPVMIITEYMENGSLDSFLRRHDGQFTIIQLVGLLRGIAAGMTYLSDLGYIHR 539

Query: 248 DVAARNCLYGGGQVL 262
           D+AARN L     V 
Sbjct: 540 DLAARNILVNSNLVC 554


>UniRef50_Q23102 Protein W01B6.5, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q23102_CAEEL
          Length = 536

 Score =  238 bits (609), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 87/315 (27%), Positives = 138/315 (43%), Gaps = 62/315 (19%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGE-------------------- 42
           +  +     +HG + RED+  +L   G FL+RTS                          
Sbjct: 101 EDFITKMPCFHGFIGREDLMSVLKNVGDFLIRTSVQPNKHEVEKMKKNQADVKVLGNLSR 160

Query: 43  ---------------------KRQFVLSVVGEKKT----------SANHFVVRESDHKVY 71
                                +R+FV+SV  + K              + V++  +  V+
Sbjct: 161 EKCAKKEKEKEEKLAGMGDVGRREFVISVYCKDKEKPATDKPQYTPIRNLVIKRDNGMVH 220

Query: 72  VDK-IGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT-KKLGE 129
           V+    F T+ E   +Y          D      L   +    WE  HED+ L  KKLGE
Sbjct: 221 VEPLRKFKTLTEFFGYYQKNSGICKETD----FQLITPIPLSNWEFIHEDIALQQKKLGE 276

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAK-LESMTKEQIKEIMREARLMRNLDHINVVK 188
           GAFGEV  GK+   L +  + V VAVK  +  E + +EQ+ E++ EAR+MR +DH NV++
Sbjct: 277 GAFGEVRIGKMK--LKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMMDHKNVLR 334

Query: 189 FFGVAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMH 246
            +G+A   EPLY++ E+   GAL   L +      + +K   +  ++ G+ Y+H +  +H
Sbjct: 335 SYGIAVLKEPLYLMTEMCACGALREYLRENQETVTLAEKLFFVVGSSRGVQYLHSQKTIH 394

Query: 247 RDVAARNCLYGGGQV 261
           RD+A RN L    + 
Sbjct: 395 RDLAVRNILLSEDRT 409


>UniRef50_Q4RV12 Ephrin receptor (Fragment) n=3 Tax=Euteleostomi RepID=Q4RV12_TETNG
          Length = 1006

 Score =  238 bits (608), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 52/204 (25%), Positives = 91/204 (44%), Gaps = 12/204 (5%)

Query: 61  FVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
           F++    +K    K        L              D        QA+     E+    
Sbjct: 607 FIISRRRNKYSKTKQDSEEEKHL------NPGVKIYVDPFTYEDPDQAIHEFAKEIDVSS 660

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           + + + +G G FGEV  G+L        + + VA+K+ K    + +Q ++ + EA +M  
Sbjct: 661 IHIERVIGMGEFGEVCSGRLR---VQGKREIYVAIKSLKAG-YSDKQRRDFLSEASIMGQ 716

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAY 238
            DH N+++  GV    +PL +I E  + G+LD+ L K    F +I+   ++   A+G+ Y
Sbjct: 717 FDHPNIIRLEGVVTRCKPLMIITEYMENGSLDAFLRKHDGQFTVIQLVGMLRGIASGMKY 776

Query: 239 IHEKNLMHRDVAARNCLYGGGQVL 262
           + + + +HRD+AARN L     V 
Sbjct: 777 LSDMSYVHRDLAARNILVNSNLVC 800


>UniRef50_P29317 Ephrin type-A receptor 2 n=31 Tax=Euteleostomi RepID=EPHA2_HUMAN
          Length = 976

 Score =  237 bits (607), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 57/205 (27%), Positives = 94/205 (45%), Gaps = 12/205 (5%)

Query: 60  HFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHE 119
           H   +    +   + + F    +L       K   +  D        QAV +   E++  
Sbjct: 559 HRRRKNQRARQSPEDVYFSKSEQL-------KPLKTYVDPHTYEDPNQAVLKFTTEIHPS 611

Query: 120 DVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
            V   K +G G FGEV+KG L     +  + V VA+KT K    T++Q  + + EA +M 
Sbjct: 612 CVTRQKVIGAGEFGEVYKGMLK--TSSGKKEVPVAIKTLKAG-YTEKQRVDFLGEAGIMG 668

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLA 237
              H N+++  GV +  +P+ +I E  + GALD  L +    F +++   ++   A G+ 
Sbjct: 669 QFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMK 728

Query: 238 YIHEKNLMHRDVAARNCLYGGGQVL 262
           Y+   N +HRD+AARN L     V 
Sbjct: 729 YLANMNYVHRDLAARNILVNSNLVC 753


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score =  237 bits (606), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 59/277 (21%), Positives = 107/277 (38%), Gaps = 40/277 (14%)

Query: 7   LHQK--YYHGLLPREDIQEML--NKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
                 +YHG + RE  +++L     G FL+R S    G+   + L +    K    H+ 
Sbjct: 40  EQHPKLWYHGNITREHTEKILSGQADGTFLVRDSTNFPGD---YTLCMAFNGK--VEHYR 94

Query: 63  VRESDHKVYVD-KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ--------- 112
           + + +  +  D +  F  + +L+ HY    +    +  T        + R          
Sbjct: 95  IYQLNGILTCDHEETFDNLTQLIAHYKRDADGLCHRLITPVISDDYRITRDNESLEERIR 154

Query: 113 -----KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQ 167
                   +   ++ L   +G G FG+V  G              VAVK  K      E 
Sbjct: 155 FFREASLIISRSEIRLGDIIGHGEFGDVLLGDYDGQR--------VAVKVLKRS----EM 202

Query: 168 IKEIMREARLMRNLDHINVVKFFGVAAGT-EPLYVIMELADGGALDSALG---KLHFPMI 223
           ++ ++ EA+ M  L H+N+V   GV       ++++ E    G L + L    +     +
Sbjct: 203 VQSLLDEAKFMIGLKHVNLVALLGVVIDDAREMFMMTEYMANGNLANFLRSRGRHQVEKM 262

Query: 224 KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
           +  +       G+ ++  KN++HRD+AARN L     
Sbjct: 263 QLTQFAIDICEGMKFLEIKNVVHRDLAARNVLLDDEL 299


>UniRef50_UPI0000DB7426 PREDICTED: similar to insulin-like growth factor 1 receptor isoform 1
            n=1 Tax=Apis mellifera RepID=UPI0000DB7426
          Length = 1422

 Score =  237 bits (605), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 65/265 (24%), Positives = 118/265 (44%), Gaps = 28/265 (10%)

Query: 16   LPREDIQEMLNKPG---QFLLRTSEPVKGEKRQFVLSVVGEKK-TSANHFVVRESDH--- 68
            +PR   Q      G    +L+R   P K   R    S+ G+ + +   HF +  +D    
Sbjct: 975  IPRSLAQP--RTDGGSSSYLIRNLSPGKYSLRMRSTSLAGDGRFSDVVHFSIDLADSAPV 1032

Query: 69   ----KVYVDKIGFPTIIELV--NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
                 + +  +   +++  V   H+   K             ++      +WE+  E VE
Sbjct: 1033 TLVALLVLCVLAMMSVVLFVVWRHHRKRKNQERLIASVNPDYIETKYVIDEWEVPRESVE 1092

Query: 123  LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
            ++ +LG G FG V++G          + + VA+KT    +  +E+  E + EA +M+N  
Sbjct: 1093 ISNELGLGNFGMVYRGVY-------DKTIPVAIKTISKTASQREK-NEFLNEASVMKNFS 1144

Query: 183  HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI-----KKYELIYQAANGLA 237
              +++K  GV +   P +VIMEL + G L + L ++    +     +   +  + A+G+A
Sbjct: 1145 TFHIIKLIGVVSIENPPFVIMELMENGDLKTYLRRIRDTRLVPDTCRIMRMAAEIADGMA 1204

Query: 238  YIHEKNLMHRDVAARNCLYGGGQVL 262
            Y+  K  +HRD+AARNC+     V 
Sbjct: 1205 YLESKKYVHRDLAARNCMVSKDLVC 1229


>UniRef50_UPI0000E47549 PREDICTED: similar to Cek8 n=2 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E47549
          Length = 775

 Score =  236 bits (602), Expect = 8e-61,   Method: Composition-based stats.
 Identities = 54/201 (26%), Positives = 91/201 (45%), Gaps = 12/201 (5%)

Query: 64  RESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVEL 123
            E+ H +Y +      I+  +      K+  +  D        QAV+    E+    + +
Sbjct: 366 SENGHLIYANGTNGEVILPHI------KKVKTYVDPFTYEDPNQAVKEFATEIDATQIRI 419

Query: 124 TKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDH 183
            + +G G FG+V  G +   L  +   + VAVKT K  +  K+   + + EA +M   DH
Sbjct: 420 LEVIGGGEFGDVCSGLM---LMPDKTTIKVAVKTLKTGATDKD-RSDFLSEASIMGQFDH 475

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHE 241
            NV+K  GV   T P  ++ E  + G+LD  L +    F + +   ++     G+ ++ E
Sbjct: 476 PNVIKLLGVVTKTRPAMIVTEFMENGSLDKYLRENDGRFTVTQLLGMMRGVGFGMRFLSE 535

Query: 242 KNLMHRDVAARNCLYGGGQVL 262
            N +HRD+AARN L     V 
Sbjct: 536 MNFVHRDLAARNILVNEHLVC 556


>UniRef50_Q4T272 Chromosome undetermined SCAF10323, whole genome shotgun sequence.
           (Fragment) n=2 Tax=Tetraodontidae RepID=Q4T272_TETNG
          Length = 815

 Score =  235 bits (601), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 52/180 (28%), Positives = 92/180 (51%), Gaps = 6/180 (3%)

Query: 85  NHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKIL 144
           N ++      +  D        QAV +   E++   + + + +G G FGEV  G L    
Sbjct: 442 NGHLQFTGLRTYVDPLTYEDPNQAVHQFAQEIHLSSISIERIIGAGEFGEVCSGPLRL-- 499

Query: 145 DANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIME 204
               + +LVA+KT K    T++Q ++ + EA +M   +H N+++  GV   ++P+ +I E
Sbjct: 500 -PGKREILVAIKTLKAG-YTEQQRRDFLWEASIMGQFNHPNIIRLEGVVTKSKPVMIITE 557

Query: 205 LADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + G+LD+ L K    F +I+   ++   A+G+ Y+ +   +HRD+AARN L  G  V 
Sbjct: 558 YMENGSLDTFLKKNDGQFTVIQLVGMLRGIASGMRYLSDMGYVHRDLAARNILVDGHLVC 617


>UniRef50_Q21764 Protein R05H5.4, partially confirmed by transcript evidence n=6
           Tax=Caenorhabditis RepID=Q21764_CAEEL
          Length = 414

 Score =  235 bits (601), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 78/256 (30%), Positives = 134/256 (52%), Gaps = 14/256 (5%)

Query: 8   HQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESD 67
           +  Y+HG L   D  ++L   G F++   + +   K Q  L+V  +K      + ++ + 
Sbjct: 13  NLPYFHGALMNIDADQLLVNEGDFMVTMKKQLDINKLQLFLAVRLKKG--IRRYEIKRTS 70

Query: 68  HKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKL 127
               +       I++L+N   +            K VLK+A+ + K++L H+DV   KK+
Sbjct: 71  KTAKIGGKTSQNIVKLINMLKADPIEI----RGEKVVLKRAIPKGKFQLMHKDVIFQKKI 126

Query: 128 GEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVV 187
           G GA+G V++GKL+K  +      ++AVK    E   ++ + E+M+EAR+M+  DH N+V
Sbjct: 127 GAGAYGTVYRGKLVKTDE------VIAVKKLDPEGADEDGLAEMMKEARVMQLYDHPNIV 180

Query: 188 KFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLM 245
           KF G      P  +++E  +GGA++  L        +  + +  Y AA G+ Y+H+KN +
Sbjct: 181 KFHGFILDDLPYLLVLEYCNGGAVEDRLRDKGEKIKVPTRVKYTYMAACGMDYLHKKNCI 240

Query: 246 HRDVAARNCLYGGGQV 261
           HRD+A+RNCL   G V
Sbjct: 241 HRDIASRNCLIHKGVV 256


>UniRef50_UPI0000DB6DD4 PREDICTED: similar to Insulin-like growth factor 1 receptor
           precursor (Insulin-like growth factor I receptor) (IGF-I
           receptor) n=1 Tax=Apis mellifera RepID=UPI0000DB6DD4
          Length = 855

 Score =  234 bits (597), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 24/236 (10%)

Query: 49  SVVGEKK-TSANHFVVRESDHKVYVDKIG---FPTII---ELVNHYVSTKESFSTKDGTV 101
           S+ G    T   +F + E +       +    F  ++    LV  Y   ++         
Sbjct: 245 SLAGNGAYTHVKYFYIEERNTMNTFWIVFWLLFCAVLAALSLVAFYACKRKFLRNVPNVT 304

Query: 102 ------KAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAV 155
                    +       +WE+  E +E+ + LG G FG V++G    I+      V  AV
Sbjct: 305 LIATVNPEYVSTPYVLDEWEVPREKIEMLRSLGTGTFGMVYEGIAKDIVK-GKSEVRCAV 363

Query: 156 KTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL 215
           KT   ++  +E+I E + EA +M+  D  +VVK  GV    +P  VIMEL   G L   L
Sbjct: 364 KTVNKDATDRERI-EFLNEASVMKGFDAHHVVKLLGVVTRGQPTLVIMELMVNGDLKRYL 422

Query: 216 GKLH---------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                          + +  ++  + A+G+AY+  K  +HRD+AARNC+      +
Sbjct: 423 RSHRPCENMSNAPPKLDRILQMAIEIADGMAYLSTKKFVHRDLAARNCMVAEDLTV 478


>UniRef50_B7QJ81 Eph receptor tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7QJ81_IXOSC
          Length = 902

 Score =  233 bits (596), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 54/178 (30%), Positives = 84/178 (47%), Gaps = 6/178 (3%)

Query: 87  YVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDA 146
           + +   S +  D        QAV     E+    + +   +G G FG+V +GKL      
Sbjct: 506 HCTGAASRAYVDPHTYEDPNQAVREFTKEIDALHITIEAIIGGGEFGDVCRGKLK---CP 562

Query: 147 NHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELA 206
               V VA+KT K  S  K ++ + + EA +M   DH NV+   GV   + P+ +I E  
Sbjct: 563 GRPEVTVAIKTLKPGSSDKARM-DFLTEASIMGQFDHPNVIFLQGVVTKSNPIMIITEYM 621

Query: 207 DGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           + G+LD+ L      F +I+   ++   A G+ Y+ E N +HRD+AARN L     V 
Sbjct: 622 ENGSLDTFLRANDGKFQVIQLVGMLRGIAAGMQYLAEMNYVHRDLAARNVLVNANLVC 679


>UniRef50_Q4SUM3 Ephrin receptor (Fragment) n=5 Tax=Tetraodontidae
           RepID=Q4SUM3_TETNG
          Length = 1173

 Score =  233 bits (596), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 52/175 (29%), Positives = 86/175 (49%), Gaps = 6/175 (3%)

Query: 90  TKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQ 149
           +       D        +AV     E+    V++ + +G G FGEV  G L +      +
Sbjct: 630 SPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGNLRQ---PGKR 686

Query: 150 PVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGG 209
            +LVA+KT K+   T+ Q ++ + EA +M   DH N++   GV   + P+ +I E  + G
Sbjct: 687 EILVAIKTLKVG-YTERQRRDFLSEASIMGQFDHPNIIHLEGVVTKSSPVMIITEFMENG 745

Query: 210 ALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +LDS L +    F +I+   ++   A G+ Y+ + N +HRD+AARN L     V 
Sbjct: 746 SLDSFLRQNDGQFTVIQLVGMLRGIAAGVKYLCDMNYVHRDLAARNILVNSNLVC 800


>UniRef50_Q93105 Insulin-like receptor beta chain n=1 Tax=Aedes aegypti
            RepID=INSR_AEDAE
          Length = 1393

 Score =  233 bits (595), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 61/257 (23%), Positives = 109/257 (42%), Gaps = 30/257 (11%)

Query: 32   LLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKV-------------YVDKIGFP 78
            LL   EP     R    ++ G+   SA  +V+   D  +             ++  +GF 
Sbjct: 925  LLTKLEPGNYSIRVMATTIAGDGAPSAARYVLIAKDDSMGTTLIWLGTLIVIFLCSVGFV 984

Query: 79   TIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKG 138
                    Y+S +     +     A ++  V    WE+    +   ++LG+G+FG V+KG
Sbjct: 985  AFYWYKYRYMSKQIRMYPEVNPDYAGVQYKV--DDWEVERNHIIQLEELGQGSFGMVYKG 1042

Query: 139  KLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEP 198
             L ++          A+KT    +  +E+    + EA +M+  +  +VV+  GV +  +P
Sbjct: 1043 ILTQL-RGEKCNQPCAIKTVNESATAREK-DSFLLEASVMKQFNTHHVVRLLGVVSQGDP 1100

Query: 199  LYVIMELADGGALDSALGKLH-------------FPMIKKYELIYQAANGLAYIHEKNLM 245
              VIMEL   G L S L +                 + +  ++  + A+G+AY+  K  +
Sbjct: 1101 TLVIMELMANGDLKSYLRRHRPDYENGEDPSPQPPTLRQIIQMAIEIADGMAYLSAKKFV 1160

Query: 246  HRDVAARNCLYGGGQVL 262
            HRD+AARNC+      +
Sbjct: 1161 HRDLAARNCMVADDMTV 1177


>UniRef50_Q4SP88 Ephrin receptor (Fragment) n=4 Tax=Euteleostomi RepID=Q4SP88_TETNG
          Length = 950

 Score =  232 bits (593), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 54/175 (30%), Positives = 86/175 (49%), Gaps = 6/175 (3%)

Query: 90  TKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQ 149
           +       D         AV     E+    V++ + +G G FGEV +G+L +   A  +
Sbjct: 605 SPGVKVYIDPFTYEDPNDAVHEFAKEIDISCVKIEEVIGAGEFGEVCRGRLKQ---AGRR 661

Query: 150 PVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGG 209
            ++VA+KT K    T+ Q ++ + EA +M   DH NV++  GV   + P+ +I E  + G
Sbjct: 662 EMVVAIKTLKAG-YTERQRRDFLAEASIMGQFDHPNVIRLEGVLTRSCPVLIITEFMENG 720

Query: 210 ALDSALG--KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           ALDS L      F M +   ++   A G+ Y+ + N +HRD+AARN L     V 
Sbjct: 721 ALDSFLRLNDGRFTMTQLVGMLRGVAAGMKYLSDMNYVHRDLAARNILVNSNLVC 775


>UniRef50_A8WPD7 Putative uncharacterized protein n=4 Tax=Caenorhabditis
           RepID=A8WPD7_CAEBR
          Length = 423

 Score =  232 bits (593), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 77/261 (29%), Positives = 133/261 (50%), Gaps = 19/261 (7%)

Query: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
           ++DL +  Y+HG L  +D  ++L   G F++     +   K    L      K     + 
Sbjct: 8   EEDL-NLPYFHGALMNQDADQLLVNDGDFMVTMKLQIDINKLVVRL------KKGIRRYE 60

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           ++       +      TI +L+N   +       +    K VLK+A+ + K++L H+DV 
Sbjct: 61  IKRLPGSAKLGSRSKETIDKLINSLKTDVLEIKGE----KIVLKRAIAKGKFQLMHKDVI 116

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
             KK+G GA+G V++G+L+K  +      ++AVK    ES  ++ + E+M+EAR+M+  D
Sbjct: 117 FKKKIGAGAYGTVYRGRLVKTNE------VIAVKKLDPESADEDGLAEMMKEARVMQLYD 170

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELIYQAANGLAYIH 240
           H N+VKF G      P  +++E  +GG+++  L        +  +    Y AA G+ Y+H
Sbjct: 171 HPNIVKFHGFILDDLPYLLVLEFCNGGSVEDRLRDKGSRLTVPTRVHYTYMAACGMDYLH 230

Query: 241 EKNLMHRDVAARNCLYGGGQV 261
           +K  +HRD+A+RNCL   G V
Sbjct: 231 KKGCIHRDIASRNCLIHRGIV 251


>UniRef50_Q19704 Protein F22B3.8, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q19704_CAEEL
          Length = 442

 Score =  232 bits (592), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 90/305 (29%), Positives = 138/305 (45%), Gaps = 54/305 (17%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTS------------------EPVKGE 42
           M D  LL  +++HG + +E    +L   G FLLR S                  +P+   
Sbjct: 1   MIDNYLLRYQFFHGFVLQELQLILLKTNGDFLLRLSHQPEKNAKKPTTPDKSATDPIPLT 60

Query: 43  KRQFVLSV-----------------VGEKKTSANHFVVRESDHK---VYVDKI-GFPTII 81
           +   VLSV                   +K+    H  + E+  K    Y+++   FPTI 
Sbjct: 61  RVILVLSVNITQKTGTTRSFYGDLEDVKKENMDMHLFIEETAGKWTSFYIERRFKFPTID 120

Query: 82  ELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT-KKLGEGAFGEVWKGKL 140
           EL+N+Y      +       +  LK+ +  Q WEL  E +++T KKLGEGAFG V+ G+ 
Sbjct: 121 ELINYYKVNPICYH----NTRVFLKRPIVLQDWELRAEGIDMTPKKLGEGAFGIVYLGRW 176

Query: 141 LKILDAN----HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGT 196
            +    +    H+   VAVKT K +  ++  + E+M EARL   L H NV+ F GV    
Sbjct: 177 AQPFSVDQKEFHKWCDVAVKTVKNDD-SRAALLEVMHEARLQLQLRHKNVLAFRGVFLLK 235

Query: 197 EPLYVIMELADGGALDSALGKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLY 256
           +P+ ++ E  +       L K    + +K      ++ GL YIH K L+HRD+A RN L 
Sbjct: 236 KPIMLVSEFCEN-----YLQKSKVSVDEKLRFCLGSSCGLEYIHFKGLIHRDLATRNILV 290

Query: 257 GGGQV 261
              + 
Sbjct: 291 SADKT 295


>UniRef50_Q9N3S5 Putative uncharacterized protein n=4 Tax=Caenorhabditis
           RepID=Q9N3S5_CAEEL
          Length = 618

 Score =  232 bits (592), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 67/284 (23%), Positives = 112/284 (39%), Gaps = 46/284 (16%)

Query: 8   HQKYYHGLLPREDIQEMLNKP----GQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVV 63
            + ++ G +     ++ + +P    G FL+R +         FVL V      S   +++
Sbjct: 200 REPWFAGNISSILAEQRVMQPQLPIGSFLIRENSKTD----TFVLVVRSSHNESPQAYII 255

Query: 64  RESDHKVYVDKI--------GFPTIIELVNHYVSTKES----FSTKDGTVKAVLKQAVER 111
               ++   +           F ++ +LVNHY   K        TK       L +  E 
Sbjct: 256 YRRPNQEGFEIRDNHRPAVIHFGSLHQLVNHYSCEKVPGEIQICTKLTKAAPPLPEQTEY 315

Query: 112 ---QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQI 168
              +K  +   +V   K++G G FGEV+  K           V VAVK+ K +   +   
Sbjct: 316 MAMKKIHVNRSEVRRVKEIGRGQFGEVYLAKWKG--------VDVAVKSLKPDHSEQLAN 367

Query: 169 KEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKY 226
            + + EA+ +  L H NV+    V    +P  +I E    G+L + L K     P I   
Sbjct: 368 TQFLEEAKTLTKLSHQNVIHLLAVCDTDKPYLIITEFMTNGSLLAWLQKLTKTLPPIPLM 427

Query: 227 -------------ELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
                         +  Q A+G+ Y+    ++HRD+AARN L G
Sbjct: 428 SEETGRKNVLIGASISAQVASGMDYLSANKIVHRDLAARNVLVG 471


>UniRef50_Q9Y1Y3 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y3_9METZ
          Length = 893

 Score =  231 bits (589), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 59/200 (29%), Positives = 89/200 (44%), Gaps = 12/200 (6%)

Query: 65  ESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT 124
                VY+      T  E+V+     K +    D        QAV     E+  + ++L 
Sbjct: 484 RPGKGVYLP----QTSSEMVD-IPQNKGTRMYVDPRTYQSTTQAVSTVATEIPPKYIKLV 538

Query: 125 KKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHI 184
           +++G G FG V+KG      +    PV +AVKT K  S  K    + + EA +M    H 
Sbjct: 539 EEIGGGEFGTVYKGMW----NERKPPVPIAVKTLKPGSSDK-MRDDFLTEASIMGQFHHP 593

Query: 185 NVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEK 242
           NV+K +GV    EP  +IME  D G+L   L        + +  ++    A G+ Y+ E 
Sbjct: 594 NVIKLYGVITKVEPAMIIMEFMDNGSLYYYLRHNDEKLSLQQLLKMACGVAAGMQYLSEV 653

Query: 243 NLMHRDVAARNCLYGGGQVL 262
             +HRD+AARN L    +V 
Sbjct: 654 GYVHRDLAARNILVSKDEVC 673


>UniRef50_P42687 Tyrosine-protein kinase SPK-1 n=1 Tax=Girardia tigrina
           RepID=SPK1_DUGTI
          Length = 497

 Score =  231 bits (589), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 58/265 (21%), Positives = 110/265 (41%), Gaps = 33/265 (12%)

Query: 16  LPREDIQEMLNK----PGQFLLRTSEPVKGEKRQFVLSVVG----EKKTSANHFVVR--- 64
           + R + ++ L K     G +++R S     ++  + LSV      +K     HF ++   
Sbjct: 105 IQRWEAEKSLMKIGLQKGTYIIRPS----RKENSYALSVRDFDEKKKICIVKHFQIKTLQ 160

Query: 65  -ESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVL--KQAVERQKWELYHEDV 121
            E      V+   FP I+ L+  Y       +    T       +  V  Q  E+  E++
Sbjct: 161 DEKGISYSVNIRNFPNILTLIQFYEKNGIGNTHIPLTDPMPDNYQPPVHFQDIEINRENI 220

Query: 122 ELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL 181
           E+  ++G G FG V + K         +   VA K       +K + ++ + EA++M  L
Sbjct: 221 EILNEIGRGFFGSVHRAKW-------GRSYEVAAKML---QSSKAEREKFVLEAKIMHKL 270

Query: 182 DHINVVKFFGVAAGTE--PLYVIMELADGGALDSALGK---LHFPMIKKYELIYQAANGL 236
            H  +V+  GV    +  P+ +I+E    G+L   L         + +   ++ + + G+
Sbjct: 271 RHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGM 330

Query: 237 AYIHEKNLMHRDVAARNCLYGGGQV 261
           AY+  + ++HRD+ A N L      
Sbjct: 331 AYLESEKVVHRDLRADNILVANDLT 355


>UniRef50_A8QEG4 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QEG4_BRUMA
          Length = 392

 Score =  231 bits (589), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 85/253 (33%), Positives = 123/253 (48%), Gaps = 12/253 (4%)

Query: 8   HQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESD 67
               +HG++P ED   +L   G FL+R  E  +G K    LS+        N  +V    
Sbjct: 25  DMDCWHGMIPDEDTAMLLKNSGDFLMRAVEHDRGYK--ITLSIRW-GNEVVNSEIVPGIQ 81

Query: 68  HKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKL 127
                    F    +L++ Y  TK   +     V   L+  + RQ WEL H+ + L KK+
Sbjct: 82  GGYKFQGKHFCQTKDLIDSYQVTKRPLTVNSIVV--TLEIPIRRQHWELQHKMIRLGKKI 139

Query: 128 GEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVV 187
           G G+FG V+KG    I     + + VAVK      +T E    + REAR+MR  DH NVV
Sbjct: 140 GSGSFGTVYKG---AITIGIKKSITVAVKELTE--ITAEASNALWREARVMRMYDHPNVV 194

Query: 188 KFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIYQAANGLAYIHEKNLM 245
           K++GVA    P Y++ME   GGA+D  L           + +++ +AA GL Y+H +  +
Sbjct: 195 KYYGVANDYTPYYLVMEFVSGGAVDEYLCKKGKKIAAKARVKILQEAAIGLEYLHRQKCL 254

Query: 246 HRDVAARNCLYGG 258
           HRD+A RN L G 
Sbjct: 255 HRDIACRNLLIGD 267


>UniRef50_B3XVX8 Protein tyrosine kinase fes/fps n=1 Tax=Codonosiga gracilis
           RepID=B3XVX8_9EUKA
          Length = 792

 Score =  230 bits (588), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 79/261 (30%), Positives = 127/261 (48%), Gaps = 19/261 (7%)

Query: 5   DLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVR 64
            +   + Y G +PR ++  +L+ PG FL+R     +    ++VLSV+ E      HF + 
Sbjct: 428 SVEDLECYFGPIPRNEVPMILSDPGDFLIRLGS--ENSATKYVLSVLEEGGN-CRHFNIF 484

Query: 65  ESDHKV-YVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL-YHEDVE 122
              +    ++K  FP+I  L+ HY+    S S   G   A     V R+K E+   +D+E
Sbjct: 485 YCPNGYVKIEKQEFPSISHLIRHYIDNDLSLSKNSGVTIA---HGVSRKKMEIWKPKDLE 541

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD 182
              KLG+G FG V K K     D        AVKT   ES+      E ++EA       
Sbjct: 542 SAAKLGKGCFGVVQKMKSKISDDVF------AVKTCSDESVHP---WEFLKEALDFAKFK 592

Query: 183 HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIK-KYELIYQAANGLAYIHE 241
           H+N+    G++  + P +++M+L   GA++S L       ++ K++   +A  G+ Y+  
Sbjct: 593 HVNICVHRGISL-SFPYFILMDLCGNGAVNSYLHDHKDTSLEIKFKWALEACEGMEYLTT 651

Query: 242 KNLMHRDVAARNCLYGGGQVL 262
            N++HRD+AARNCL     VL
Sbjct: 652 NNVVHRDLAARNCLLTDDLVL 672


>UniRef50_O44570 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=O44570_CAEEL
          Length = 448

 Score =  230 bits (587), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 89/283 (31%), Positives = 143/283 (50%), Gaps = 43/283 (15%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEK---RQFVLSVVG----- 52
           + +K L    +YHG  PRED+Q  L+  G FLLR SE V+GE    R+ +LS++      
Sbjct: 170 ILEKKLREFNFYHGFFPREDLQTTLHNLGDFLLRVSEVVEGEHKVNREVILSLIPVSTVS 229

Query: 53  ---EKKTSA---------------------NHFVVRESDHKVYVD-KIGFPTIIELVNHY 87
              E+K                         + V++   +  + +    F +I +L+N+Y
Sbjct: 230 RDEEEKKKVRRLIQANAPACCLYFLTYLAPRNVVIKRVRNLFFCEPPRTFESISDLLNYY 289

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
                  ++        LK  + +Q WE  H DV + K LGEGAFG+V  G L      +
Sbjct: 290 TKNHGGCASGT----FQLKHPILQQSWEFMHSDVTIGKVLGEGAFGKVCSGTLKL---KD 342

Query: 148 HQPVLVAVKTAKLES-MTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELA 206
              V VA+K  K+ + ++K +IKE+M EAR +RN +H NVV+ +GVA   +PLY+++EL 
Sbjct: 343 GTNVDVAIKMTKVSAFLSKMKIKEMMNEARFIRNFNHKNVVRLYGVAHHEQPLYILLELV 402

Query: 207 DGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHR 247
            GG+L   + K      ++++ +    A  G+ Y+H+ N +HR
Sbjct: 403 KGGSLQDHMKKEKGAVSIVERIKFCRGAGRGIEYLHQNNCIHR 445


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score =  229 bits (585), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 56/231 (24%), Positives = 106/231 (45%), Gaps = 23/231 (9%)

Query: 35  TSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESF 94
            S  + G  +  V  +V +     ++F +   +   +V +   P+       +++  E  
Sbjct: 354 PSSRIPGPNQFEVNPIVHQSNAEISNFPLTHINPVSHVPRPFHPS-------HINNSERL 406

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           S    ++ +     +E   WE+   ++ + +KLG G +G+V++    +         +VA
Sbjct: 407 SAYSDSIGS-----MEFDGWEIDRPEIIMRQKLGCGQYGDVYEAVWKRFNS------VVA 455

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           VKT K +      + + ++EA +M+ L + N+V+  GV     PLY+I E    G L + 
Sbjct: 456 VKTLKQDVNL--NVNDFLKEAAIMKKLRNRNLVQLLGVCTRELPLYLITEYMPNGNLLNY 513

Query: 215 LGKL---HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L          +    +  Q A+G+AY+   N +HRD+AARNCL G   ++
Sbjct: 514 LRTRSPGELTPLTLLYMAVQIASGMAYLEANNFIHRDLAARNCLVGDQHLI 564



 Score = 94.7 bits (235), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 21/102 (20%), Positives = 42/102 (41%), Gaps = 9/102 (8%)

Query: 9   QKYYHGLLPREDIQEMLNK--PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES 66
             +YHG + R+  + +L     G FL+R SE   G+     LSV         H+ + + 
Sbjct: 239 YSWYHGAVSRQAGEHLLRSGITGSFLVRASESAPGQ-----LSVTVRHLGRVYHYRISQD 293

Query: 67  DHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLK 106
              ++   +   FPT+++L+ H+  + +             +
Sbjct: 294 SRGLFYITEAHRFPTVVQLIEHHSRSADGLVCPLLYSVPKPQ 335


>UniRef50_B3XVX1 Protein tyrosine kinase syk (Fragment) n=1 Tax=Monosiga ovata
           RepID=B3XVX1_9EUKA
          Length = 835

 Score =  229 bits (585), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 82/302 (27%), Positives = 129/302 (42%), Gaps = 61/302 (20%)

Query: 13  HGLLPREDIQEMLN----KPGQFLLRTSEP------VKGEKRQFVLSVVGEKKTSANHFV 62
           +GLL R+  + +L     K G +L+R ++         G    FV+SV+ + +    H +
Sbjct: 113 YGLLGRDAAEALLQRLSPKDGSYLVRQTDKPTPDDRFPGAMAHFVVSVLHKGRGQ--HLL 170

Query: 63  VRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWEL---- 116
           +R+     Y   D + + T+ ELV+HY   ++    +      +L QA       +    
Sbjct: 171 IRKFPSGKYGIDDGLRYRTLAELVDHYRHGRDGLCCELRENVFLLDQARPNDAGRIISAI 230

Query: 117 ----------------------------YHEDVELTK------KLGEGAFGEVWKGKLLK 142
                                           V L+K      KLGEG FG V KG L K
Sbjct: 231 KTRFAKLSAAAPAQSRSSSSSSLPKPASLESAVILSKYISTSTKLGEGEFGTVLKGVLTK 290

Query: 143 ILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVI 202
                  P+ VAVK  K+ +       E+ +EA  M NLDH NVV+  GV   +  L ++
Sbjct: 291 ---PGQSPIAVAVKALKIGADD----NELRKEALTMVNLDHPNVVRMLGVCTDSPTLQLV 343

Query: 203 MELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
           +EL   GA++S L        + +    I Q A G+ Y+   +++HRD+AARN L G   
Sbjct: 344 VELLPNGAINSYLRAHETSIQLGQLMSFITQIAEGMLYLEGMHVIHRDLAARNVLVGERD 403

Query: 261 VL 262
           ++
Sbjct: 404 MV 405



 Score = 76.6 bits (188), Expect = 8e-13,   Method: Composition-based stats.
 Identities = 30/132 (22%), Positives = 57/132 (43%), Gaps = 15/132 (11%)

Query: 135 VWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD------HINVVK 188
           V  G   +     +    V VK  + +   +E  K  + E  ++  ++      H N+V 
Sbjct: 584 VCVGPYSRAFKGTYGRDPVIVKAMRQK---REARK--LSE--VLAKIEGVQKAPHRNLVI 636

Query: 189 FFGVAAGTE-PLYVIMELADGGALDSALGKLH-FPMIKKYELIYQAANGLAYIHEKNLMH 246
             G A+  +  L ++ E    G LD+ + +     +      I Q A+GLA++H+  ++H
Sbjct: 637 LHGPASLPDLGLVIVAEAVALGPLDAYIRRTPALTLDHCARFITQIASGLAFLHKHGIVH 696

Query: 247 RDVAARNCLYGG 258
            D+AAR+     
Sbjct: 697 SDLAARHVFVAS 708


>UniRef50_UPI000180C9B0 PREDICTED: ephrin receptor gamma n=1 Tax=Ciona intestinalis
           RepID=UPI000180C9B0
          Length = 1062

 Score =  228 bits (583), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 50/175 (28%), Positives = 86/175 (49%), Gaps = 6/175 (3%)

Query: 90  TKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQ 149
                +  D T     ++AV     E+    +++ + +G G FGEV +G+L      N  
Sbjct: 617 QSNHKTYIDPTTYEDPQRAVSEFTKEIDATYIKIEQVIGAGEFGEVCRGRL---QLPNKP 673

Query: 150 PVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGG 209
              VA+KT K    T++++ + + EA +M   DH NV++  GV   + PL +I E  + G
Sbjct: 674 ESDVAIKTLKTGYSTQQKL-DFLGEASIMGQFDHPNVIRLEGVVTKSRPLMIITEFMENG 732

Query: 210 ALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +LD+ L      F +I+   ++   A G+ Y+ +   +HRD+AARN L     + 
Sbjct: 733 SLDAFLRNHDNGFTVIQLVGILRNIAAGMKYLSDMGYVHRDLAARNILVNAQLIC 787


>UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYM5_SCHMA
          Length = 670

 Score =  228 bits (583), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 68/306 (22%), Positives = 114/306 (37%), Gaps = 67/306 (21%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLN--KPGQFLLRTSEPVKGEKRQFVLSVVG--------- 52
           ++L    +YHG + R + + +L+    G FL+R S+   G      L VVG         
Sbjct: 76  ENLKDHCWYHGRISRAESESLLSGSPVGSFLIRESDLYSG---GLTLCVVGPACAVGSPD 132

Query: 53  ------------EKKTSANHFVVRESD---------------------HKVYVDKIGFPT 79
                          T+  H+ +                         H    +   F +
Sbjct: 133 TTEHQNSTVTPPNTMTNVQHYRIVRRPFKATPSNQHSEYSTPLICSKIHYTLDETDWFSS 192

Query: 80  IIELVNHYVSTKESFSTKDGTVKAVLKQAV----ERQKWELYHEDVELTKKLGEGAFGEV 135
           ++ELV  Y   K             +++      ++  + ++ +++ L  ++G G FGEV
Sbjct: 193 LLELVQFYSEPKRGLVCALLHPVPDMQRKRLSELQKFGYLIFRKEIALGDRIGRGEFGEV 252

Query: 136 WKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAG 195
            K               VAVK  K  +        I  EA LM  L+H N+V F G+   
Sbjct: 253 LKATYRGR--------QVAVKIYKKTAS----KLAITYEASLMTKLNHPNLVSFIGLVYE 300

Query: 196 -TEPLYVIMELADGGALDSALGKL---HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAA 251
             + +Y+I E    G+L + L          + K +       GL Y+ E++ +HRD+AA
Sbjct: 301 PDDAVYLITEYLSNGSLLTYLHSRTRDEITELTKLKFSIDVCRGLVYLEERDFIHRDIAA 360

Query: 252 RNCLYG 257
           RN L  
Sbjct: 361 RNVLLS 366


>UniRef50_Q5D184 Ephrin receptor n=5 Tax=Neoptera RepID=Q5D184_APIME
          Length = 996

 Score =  228 bits (582), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 51/170 (30%), Positives = 81/170 (47%), Gaps = 4/170 (2%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           S  D        QAV     E+    + +   +G G FG+V +GKL  +       + VA
Sbjct: 607 SYVDPHTYEDPNQAVREFAREIDAGYITIEAIIGGGEFGDVCRGKLK-LPPDGRTEIDVA 665

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           +KT K  S  K    + + EA +M   +H NV+   GV   + P+ +I E  + G+LD+ 
Sbjct: 666 IKTLKPGSADK-ARNDFLTEASIMGQFEHPNVIFLQGVVTKSNPVMIITEFMENGSLDTF 724

Query: 215 LGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L      F +++   ++   A+G+ Y+ E N +HRD+AARN L     V 
Sbjct: 725 LRANDGKFQVLQLVGMLRGIASGMQYLAEMNYVHRDLAARNVLVNAALVC 774


>UniRef50_A8XT57 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8XT57_CAEBR
          Length = 579

 Score =  228 bits (582), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 68/299 (22%), Positives = 120/299 (40%), Gaps = 51/299 (17%)

Query: 6   LLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRE 65
           L H  +YHG++    ++++L     +L+R +      K+   +SV  + K         E
Sbjct: 66  LKHHLWYHGMMFGGTVEKLLKWEHSYLVRRAIQRSSMKKTLCISVKIDGKVLNFQLTWNE 125

Query: 66  SDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTK 125
                      FP + +    Y    +       +V A+    V R +  L+H  + L  
Sbjct: 126 DGWGSTKLVAKFPKMAQ--KRYAHIYQLLDAWSLSVNAIT--PVPRNRIVLHHSSITLGN 181

Query: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
           KLG GAFGEV++ K   + +   + + VAVK A +    +  I+E   EA++M  L H+N
Sbjct: 182 KLGSGAFGEVYRAKY--LPNGASESIEVAVKRA-IGDAQRSTIQEFCHEAQVMGVLQHVN 238

Query: 186 VVKFFGVAAGTEPLYVIMELADGGALD--------------------------------- 212
           +V  +G+A+  +P+ ++MEL  GG L                                  
Sbjct: 239 IVCLYGIASLEQPVMLVMELVTGGDLRLCREMLLNTFRDAHALNFEGAEINTHFRYMNNP 298

Query: 213 ----------SALG-KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
                       L    +    +        A+G+ ++ ++ ++HRD+AARNCL     
Sbjct: 299 IRFPNSLKFQKHLQTTHNISHRQLITFAADIASGMKHMAQRRVIHRDLAARNCLITNSL 357


>UniRef50_B7QM19 Tyrosine-protein kinase receptor n=2 Tax=Ixodes scapularis
            RepID=B7QM19_IXOSC
          Length = 1458

 Score =  227 bits (581), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 54/177 (30%), Positives = 87/177 (49%), Gaps = 18/177 (10%)

Query: 102  KAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLE 161
               +    E  +WE+  E + L K LG+G+FG V++G L+  L  +      AVKT    
Sbjct: 1030 PEYVSSVYEPDEWEVPRESINLVKALGQGSFGMVYEG-LIYNLKPDKPETKCAVKTVNES 1088

Query: 162  SMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP 221
            +  +E+I E ++EA +M+     +VVK  GV +  +P+YVIMEL   G L S L     P
Sbjct: 1089 ASMRERI-EFLQEAAVMKAFSCQHVVKLLGVVSKDQPVYVIMELMSNGDLKSYLRSHRPP 1147

Query: 222  ----------------MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                            + +  ++  + A+G+AY+     +HRD+AARNC+      +
Sbjct: 1148 TEGEEDDSKPRGQPPSLKQILQMAAEIADGMAYLTASKFVHRDLAARNCMVAEDLTV 1204


>UniRef50_C4PYF4 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYF4_SCHMA
          Length = 855

 Score =  227 bits (580), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 67/339 (19%), Positives = 125/339 (36%), Gaps = 99/339 (29%)

Query: 3   DKDLLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVVGE-----K 54
              L    +Y+  + R+  + +L   N+ G FL+R S   K     + LSV  +      
Sbjct: 369 PNSLNSFDWYYKDITRQQAEAILLDENREGCFLVRDSVSKKN---TYTLSVTSKDPEAPG 425

Query: 55  KTSANHFVVRESD----------------------------------------------H 68
           K   +H+ +  ++                                              +
Sbjct: 426 KLKVHHYHIHRTESSSLNGHLNGCGVGSGSGSNSGLNSTASVAATSITVTTTTNTIVNMN 485

Query: 69  KVYVDKIGFPTIIELVN----HYVSTKE-----------------SFSTKDGTVK----- 102
                    P +   +N    +Y+S K                      +  +       
Sbjct: 486 GSTGTGSNTPKVGSTINGEAQYYLSEKHAFPTISDVIHYHKHNSGGLVVRLRSPPTKDRE 545

Query: 103 AVLKQAVERQKWELYHEDVELTKK-LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLE 161
           + +   +   ++EL   ++ L ++ +G+G FG V +GK           + VAVK     
Sbjct: 546 SPVTAGMGLDEFELDPAELHLEREPIGKGQFGVVKRGKFRN--------IPVAVKQMVEG 597

Query: 162 SMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP 221
           +M ++   + + EA+ MR L+H N+V+ FGV     P+ +I E    G+L   + +    
Sbjct: 598 AMNED---DFIEEAKNMRFLNHPNLVQLFGVVLKKRPIMIITEYMKHGSLRDFMRQRQTQ 654

Query: 222 ----MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLY 256
                +   ++  Q ANG+AY+ ++  +HRD+AARNCL 
Sbjct: 655 FCNRPVVMSDICAQVANGMAYLEQEQFVHRDLAARNCLV 693


>UniRef50_Q25410 Putative molluscan insulin-related peptide(s) receptor beta chain n=8
            Tax=Coelomata RepID=MIPR_LYMST
          Length = 1607

 Score =  227 bits (580), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 51/190 (26%), Positives = 91/190 (47%), Gaps = 14/190 (7%)

Query: 86   HYVSTKESFSTKDGTV---KAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLK 142
            +Y     S      +        +      +WE+  + ++L K+LG+G+FG V++G    
Sbjct: 999  YYKQKIRSDDMTVISRNMNYVPSEILYISDEWEVDRDKIKLIKELGQGSFGMVYEGVAKG 1058

Query: 143  ILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVI 202
            I D  ++ + VAVKT   +  +    +E ++EA  M+     +VVK  GV +  +P  VI
Sbjct: 1059 IRDDPNEEIPVAVKTVN-DRASFSDRREFLKEATTMKEFHCHHVVKLLGVVSTGQPALVI 1117

Query: 203  MELADGGALDSALGKLHFP----------MIKKYELIYQAANGLAYIHEKNLMHRDVAAR 252
            MEL   G L + L                ++   ++  + A+G+AY+ +K  +HRD+AAR
Sbjct: 1118 MELMALGDLKNYLRGHRPDEDHPGVMPPHLLDILQMAGEIADGMAYLADKKFVHRDLAAR 1177

Query: 253  NCLYGGGQVL 262
            NC+    + +
Sbjct: 1178 NCMVSEERTV 1187


>UniRef50_Q4H3M4 Ephrin receptor n=1 Tax=Ciona intestinalis RepID=Q4H3M4_CIOIN
          Length = 1048

 Score =  227 bits (579), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 50/193 (25%), Positives = 90/193 (46%), Gaps = 11/193 (5%)

Query: 78  PTIIELVNHYVST------KESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGA 131
             +   V  ++            +  D T      +AV     E+    + + + +G G 
Sbjct: 594 EKLPMFVMGHLKNGSIGYMPGHKTYIDPTTYEDPARAVLDFTKEIDASYIGIEEVIGGGE 653

Query: 132 FGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFG 191
           FGEV  G++   L  + +   VA+KT K    T++++ + + EA +M   DH NV++  G
Sbjct: 654 FGEVCLGRMR--LPNSKKEHDVAIKTLKAGYSTQQKL-DFLGEASIMGQFDHPNVIRLEG 710

Query: 192 VAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
           V   ++P  +I E  + G+LD+ L K    F +I+   ++   A G+ Y+ +   +HRD+
Sbjct: 711 VVTKSQPHMIITEYMENGSLDTFLRKHDGEFTVIQLVGILRNIAAGMKYLSDMGYVHRDL 770

Query: 250 AARNCLYGGGQVL 262
           AARN L     + 
Sbjct: 771 AARNILVNAQLIC 783


>UniRef50_A8P3F9 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P3F9_BRUMA
          Length = 441

 Score =  227 bits (579), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 78/263 (29%), Positives = 139/263 (52%), Gaps = 15/263 (5%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANH 60
           M++++     ++HG L  +D+ ++L   G FLL+T      +K + +L++    +T    
Sbjct: 1   MSEEN--SLPFFHGALLDDDVDKLLELNGDFLLQTKFEQSKKKNKLILAIRHGHRT--IR 56

Query: 61  FVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHED 120
             +   +    +    F T+  L+ +Y    E      G    +L++ +++ ++EL H D
Sbjct: 57  IPISRLEKGYRIFGRSFSTMNTLIKYYQ---EHNIEAHGIDSLLLRRPIKKGRFELNHSD 113

Query: 121 VELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN 180
           +++ KK+G GA+G V+KG LLK L        VA+K       +++ + ++M+EAR+M+ 
Sbjct: 114 IKIMKKIGYGAYGTVYKGILLKNL------CPVAIKRIDCADKSEQALIDLMKEARVMQL 167

Query: 181 LDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGK--LHFPMIKKYELIYQAANGLAY 238
            DHINVVKF+G     EP  ++ME    G+++  L +      +  + ++  Q A GL Y
Sbjct: 168 YDHINVVKFYGFIVDREPFLLVMEYCKDGSVEDKLRQYGRRLSIESRIDIACQIARGLEY 227

Query: 239 IHEKNLMHRDVAARNCLYGGGQV 261
           +H K  +HRD+A RNCL  G  V
Sbjct: 228 LHLKGCIHRDIATRNCLLNGAVV 250


>UniRef50_Q9V4E5 Eph receptor tyrosine kinase, isoform C n=25 Tax=Diptera
           RepID=Q9V4E5_DROME
          Length = 1096

 Score =  227 bits (579), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 50/173 (28%), Positives = 85/173 (49%), Gaps = 4/173 (2%)

Query: 92  ESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPV 151
            S S  D        QA+     E+    + +   +G G FG+V +G+L  I     Q +
Sbjct: 712 NSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLK-IPPNFVQDI 770

Query: 152 LVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGAL 211
            VA+KT K  S +++   + + EA +M   DH NV+   GV   + P+ +I E  + G+L
Sbjct: 771 DVAIKTLKPGS-SEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSL 829

Query: 212 DSALG--KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           D+ L      F  ++   ++   A+G++Y+ + N +HRD+AARN L     + 
Sbjct: 830 DTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLIC 882


>UniRef50_Q4H3M7 Ephrin receptor n=3 Tax=Ciona RepID=Q4H3M7_CIOIN
          Length = 1006

 Score =  226 bits (578), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 51/170 (30%), Positives = 79/170 (46%), Gaps = 11/170 (6%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
           +  D +       AV+    E+  + V + + +G G FGEV KG              VA
Sbjct: 620 TYVDPSTYEDPYNAVKEFAKEIDFKLVNIEQVIGRGEFGEVCKGTFFNKC--------VA 671

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           +KT K+   T+E   + + EA +M   DH NV++  GV   + PL +I E  + G+LD+ 
Sbjct: 672 IKTLKVGYNTQE-RSDFLGEASIMGQFDHPNVIRLEGVVTKSRPLMIITEFMENGSLDAF 730

Query: 215 LGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L       P  +  E++   A G+ Y+     +HRD+AARN L     V 
Sbjct: 731 LRNQEGKIPSAQLTEMLLSIAQGMEYLSNMGYVHRDLAARNILVNSNLVC 780


>UniRef50_UPI00019252ED PREDICTED: similar to predicted protein n=1 Tax=Hydra
           magnipapillata RepID=UPI00019252ED
          Length = 686

 Score =  226 bits (577), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 48/189 (25%), Positives = 83/189 (43%), Gaps = 15/189 (7%)

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
             +K  +          + +     +WE+  + + +T+ LGEGAFG V K   + +    
Sbjct: 331 SESKAMYPGDLDVSFLDVFEIPFDPEWEVDRDCLHITETLGEGAFGVVVKADAVGLKKCE 390

Query: 148 HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELA 206
                VAVK  K ++ T+ ++ +++ E   M+ +  HIN++ F G    ++P+YVI+E A
Sbjct: 391 ENHTTVAVKMLKADA-TENELLDLLSEMETMKQIGRHINIINFLGCCTQSDPVYVIVEYA 449

Query: 207 DGGALDSALGKLH-------------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARN 253
             G L   L                   +        Q A G+ Y+  K  +HRD+AARN
Sbjct: 450 PNGNLRQFLRSKRPPMSDNGYRSDPLLSVKDIVSFALQIAKGMEYLASKKCIHRDLAARN 509

Query: 254 CLYGGGQVL 262
            L     ++
Sbjct: 510 ILVTEDYIM 518


>UniRef50_A8XI09 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8XI09_CAEBR
          Length = 468

 Score =  226 bits (577), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 79/251 (31%), Positives = 129/251 (51%), Gaps = 17/251 (6%)

Query: 19  EDIQEMLNKPGQFLLRTSEPVKGEKRQF-VLSVVGEKKTSANHFVVRESDHK-----VYV 72
            D +  L   G +LLR +EP +G   QF V+SV  E      H  + +          ++
Sbjct: 56  HDAEMSLRYVGDYLLRRAEPTEGIGGQFLVISVKREGGFV--HVPLSQDREGPLKQFYFM 113

Query: 73  DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAF 132
             +   +++ +++ +++          T  A L++ V R  W + HEDV L KK+G GAF
Sbjct: 114 PTVKDTSVLSVIDGHLARGLPIC---ITWNAYLRKPVNRSTWLIAHEDVILYKKIGSGAF 170

Query: 133 GEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRN-LDHINVVKFFG 191
           GEV+  ++  +   +   +  AVK  K+E+    +++  M+EAR+MR    H +VV  FG
Sbjct: 171 GEVFLARM--VDPTSEYVLDCAVKKLKMEATMDAKLR-FMKEARMMRKCYKHKHVVMIFG 227

Query: 192 VAAGTEPLYVIMELADGGALDSALGKLH--FPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
           +A    PL ++MEL   G+L S L K      ++ K     +A++GLA++ + N +HRDV
Sbjct: 228 IATLNSPLLILMELCPNGSLVSHLRKNKGKVTVLDKLRFSAEASSGLAHLEKMNCIHRDV 287

Query: 250 AARNCLYGGGQ 260
           AARNCL     
Sbjct: 288 AARNCLLSSKN 298


>UniRef50_Q4SFJ9 Chromosome 7 SCAF14601, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SFJ9_TETNG
          Length = 761

 Score =  225 bits (574), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 50/169 (29%), Positives = 81/169 (47%), Gaps = 6/169 (3%)

Query: 96  TKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAV 155
             D        +AV     E+    V++ + +G G FGEV +G+L        +   VA+
Sbjct: 384 YIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVCRGRLK---IPGKKENYVAI 440

Query: 156 KTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL 215
           KT K    T +Q ++ + EA +M    H N++   GV   + P+ ++ E  + GALDS L
Sbjct: 441 KTLK-GGYTDKQRRDFLSEASIMGQFQHPNIIHLEGVITASCPVMILTEFMENGALDSFL 499

Query: 216 G--KLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                 F  I+   ++   A+G+ Y+ E + +HRD+AARN L     V 
Sbjct: 500 RLNDSQFTPIQLVGMLRGIASGMKYLSEMSYVHRDLAARNILINSNLVC 548


>UniRef50_Q98TD0 Ephrin receptor n=6 Tax=Amniota RepID=Q98TD0_CHICK
          Length = 969

 Score =  225 bits (574), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 51/170 (30%), Positives = 80/170 (47%), Gaps = 6/170 (3%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
              D        + V     EL    V +   +GEG FGEV++G L        + ++VA
Sbjct: 590 PYVDLQPYDDPSRGVLEFIKELDVSCVTMENVIGEGEFGEVYRGSLRL---PGKERIVVA 646

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           +KT K  + +  Q    +REA +M   +H N+V   GV     P+ +I E  + GALD+ 
Sbjct: 647 IKTLK-STYSDSQWWNFLREATIMGQFNHPNIVHLEGVVTKRRPMMIITEYMENGALDTF 705

Query: 215 LGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L +    F  ++   ++   A+G+ Y+ E N +HRD+AARN L       
Sbjct: 706 LRENEEKFSPVQLVNMLQGIASGMTYLSEHNYVHRDLAARNILVTRSLQC 755


>UniRef50_UPI00017923B4 PREDICTED: similar to insulin receptor n=1 Tax=Acyrthosiphon pisum
            RepID=UPI00017923B4
          Length = 1475

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 15/191 (7%)

Query: 83   LVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLK 142
            L  +Y +   S           +    +  +WE+  +DVE+ + LG G+FG V++G   K
Sbjct: 1051 LHRYYKNKLASTRLFVTCNPDYVSCEYQTDEWEIPRDDVEVLEPLGRGSFGMVYRGNWKK 1110

Query: 143  ILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVI 202
                 ++ V  A+KT   E+       + + EA +M+     +VV+ +GV +  +P +V+
Sbjct: 1111 ---KENEIVPCAIKTV-TENNNMMVRHDFLSEANVMKEFCSAHVVRLYGVVSQGQPAFVL 1166

Query: 203  MELADGGALDSALGKLH-----------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAA 251
            MEL   G L S L K               +     +  + A+G++Y+  K  +HRD+AA
Sbjct: 1167 MELMPQGDLKSYLLKHRPEMTTDPSLKPPTLRDNLRMAIEIADGMSYLSFKKYVHRDLAA 1226

Query: 252  RNCLYGGGQVL 262
            RNC+     ++
Sbjct: 1227 RNCMVSDNNIV 1237


>UniRef50_UPI000186E0DC Insulin receptor precursor, putative n=2 Tax=Pediculus humanus
            corporis RepID=UPI000186E0DC
          Length = 1289

 Score =  224 bits (571), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 48/163 (29%), Positives = 85/163 (52%), Gaps = 13/163 (7%)

Query: 111  RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
              +WE+  E++EL ++LG+G+FG V++G    I+    + V  AVKT    S  ++++ E
Sbjct: 927  PDEWEVPRENIELIRELGQGSFGMVYEGIARDIVQGEPE-VRCAVKTVNEVSTDRDRM-E 984

Query: 171  IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH----------- 219
             + EA +M+  +  +VV+  GV +  +P  V+MEL   G L + L               
Sbjct: 985  FLNEASVMKAFNTHHVVQLLGVVSEGQPTLVVMELMVNGDLKTYLRSHRPEFCEDKKKQP 1044

Query: 220  FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              + +   +  + A+G+AY+  K  +HRD+AARNC+      +
Sbjct: 1045 PTLRRIIRMAMEIADGMAYLAAKKFVHRDLAARNCMVAEDLTV 1087


>UniRef50_Q9XXE5 Protein Y43C5B.2, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q9XXE5_CAEEL
          Length = 245

 Score =  224 bits (571), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 85/226 (37%), Positives = 128/226 (56%), Gaps = 16/226 (7%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVG---EKKTS 57
           M    +  + YYHG LPRED++ +L   G F++R SEP  G  R  +LSV+      +  
Sbjct: 8   MQRPSIEKEPYYHGFLPREDVKTVLKNNGDFVIRISEPQAGSPRSNILSVMHCVPPMEEE 67

Query: 58  ANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELY 117
             H+V++    K++++K+ F +I E+V  +++ KES           L +A+ RQ WEL 
Sbjct: 68  IKHYVIKTKGDKIFIEKVSFLSIPEMVEWHLTKKESVQKD-----VFLIKAISRQAWELD 122

Query: 118 HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
           H+++E  KKLGEGAFGEV  G +        + V VA+K AKL ++TKEQIKE M EAR+
Sbjct: 123 HDNIEPLKKLGEGAFGEVMMGTMK--FRKGGKSVQVAIKQAKLSNLTKEQIKEFMGEARV 180

Query: 178 MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI 223
           MR+L H +VV+F+GV      + +        +L+  L K H  + 
Sbjct: 181 MRSLSHPHVVRFYGVPRRRVNVAL------CRSLNEFLAKCHRKLR 220


>UniRef50_C5H7R9 Venus kinase receptor (Fragment) n=2 Tax=Tribolium castaneum
            RepID=C5H7R9_TRICA
          Length = 1293

 Score =  223 bits (570), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 58/188 (30%), Positives = 91/188 (48%), Gaps = 17/188 (9%)

Query: 88   VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
              T++        ++    Q  +  KWE+    V + +KLGEGAFG V+ G+       +
Sbjct: 868  KYTEQYMRHFGIDLRLNPSQITDLDKWEIPRNSVVINRKLGEGAFGTVYGGEA---NFPD 924

Query: 148  HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELAD 207
               V VAVKT K+ S T+E++ + + EA +M+  DH N++K  GV    EP+Y IME   
Sbjct: 925  KGWVAVAVKTLKVGSSTEEKL-DFLSEAEVMKRFDHKNIIKLLGVCTKEEPIYTIMEFML 983

Query: 208  GGALDSAL--GKL-----------HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNC 254
             G L + L   +                 K   +    A GL+Y+ +   +HRDVA+RNC
Sbjct: 984  YGDLKTFLLARRHLVNDKTIEESDEISSKKLTMMALDVARGLSYLAQLKYVHRDVASRNC 1043

Query: 255  LYGGGQVL 262
            L    +++
Sbjct: 1044 LINAQRIV 1051


>UniRef50_B4LZ52 GJ23294 n=4 Tax=Coelomata RepID=B4LZ52_DROVI
          Length = 1966

 Score =  223 bits (569), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 59/257 (22%), Positives = 101/257 (39%), Gaps = 23/257 (8%)

Query: 25   LNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDHKVYVD-----KIGFPT 79
            LN+ G +++      K   R    S+ GE   +   +V          +      IGF  
Sbjct: 1050 LNQSG-YVVTNLNEGKYSFRIRANSLAGEGDLTDFVYVTVPPPGLSPFEWAGYALIGFMG 1108

Query: 80   IIE--LVNHY-----VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAF 132
            I+   L+ +                                WE+  E +     LG+G+F
Sbjct: 1109 IVVCFLIYYKFFRAKKGHPRDLVINTEVNPFYASLQYVPDDWEVPRERIIQLGPLGQGSF 1168

Query: 133  GEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGV 192
            G V++G L        + +  A+KT    +  +E     + EA +M+  D  +VV+  GV
Sbjct: 1169 GMVYEGILK--AQNTGEDIPCAIKTVNENATDRE-RTNFLSEASVMKEFDTYHVVRLLGV 1225

Query: 193  AAGTEPLYVIMELADGGALDSALGKLHFPMIK-------KYELIYQAANGLAYIHEKNLM 245
             +  +P  V+MEL   G L S L        +        +++  + A+G+AY+  K  +
Sbjct: 1226 CSCGQPALVVMELMKKGDLKSYLRAHRPDEREDPPPYSRIFQMAIEIADGMAYLAAKKFV 1285

Query: 246  HRDVAARNCLYGGGQVL 262
            HRD+AARNC+      +
Sbjct: 1286 HRDLAARNCMVAEDLTV 1302


>UniRef50_UPI0001925F5B PREDICTED: similar to ephrin receptor EphA5 n=2 Tax=Hydra
           magnipapillata RepID=UPI0001925F5B
          Length = 747

 Score =  222 bits (567), Expect = 9e-57,   Method: Composition-based stats.
 Identities = 52/213 (24%), Positives = 93/213 (43%), Gaps = 20/213 (9%)

Query: 52  GEKKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER 111
            +K+  A   VVR  D  V +    +                    D     ++  AV +
Sbjct: 287 WKKRNPAYLQVVRMEDGTVKLPARFY-------------SGGKLYVDPKTFLLVSDAVSQ 333

Query: 112 QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             +E+   ++   + +G G F +V KG L+K      +   VA+K  K  + ++   ++ 
Sbjct: 334 FAYEIERSEIVFGELIGSGEFADVHKGVLMK----EGKKEPVAIKVLKNGA-SESDREDF 388

Query: 172 MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELI 229
           + EA ++    + NV+   GV    EP  +++E  + GALDS L +    F + +  E+ 
Sbjct: 389 LSEAAILGQFSNPNVIFLEGVVLKDEPNLIVLEYMEYGALDSYLKEHDMQFTIEQLLEMA 448

Query: 230 YQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              A+G+ Y+ E   +HRD+AARN L    +  
Sbjct: 449 RGVASGMKYLSEMGFVHRDLAARNILVNEKKTC 481


>UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rerio
           RepID=Q910A2_DANRE
          Length = 586

 Score =  222 bits (567), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 70/302 (23%), Positives = 117/302 (38%), Gaps = 59/302 (19%)

Query: 7   LHQKYYHGLLPREDIQEMLNK----PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFV 62
               ++HG + RED +  L       GQ   +T      ++    L ++   +    H+ 
Sbjct: 159 EKMPWFHGKIDREDSELRLLNTSRVNGQISNQTKRKQWQKRVPNALCLLHNNQ--VMHYR 216

Query: 63  V-RESDHKVYV-DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQ------------- 107
           + ++   K+ + D   F T+ +LV HY    +                            
Sbjct: 217 IDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHSEGSAENPYKIT 276

Query: 108 ------------------AVERQKWE-------------LYHEDVELTK-KLGEGAFGEV 135
                              ++ Q +E             +   D+ L   +LG G FG V
Sbjct: 277 SNGKDNYSKQGNFLDSAMPMDTQVYESPYADPDELRSTKVNRSDLTLEDGELGSGNFGTV 336

Query: 136 WKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAG 195
            +G             +VAVK  K +        E++REA +M+ LD+  +V+  G+   
Sbjct: 337 LRGVY----QMKKTQKVVAVKILKNDDDNAAVKDEMLREANVMQQLDNPYIVRMIGIC-E 391

Query: 196 TEPLYVIMELADGGALDSALGKL-HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNC 254
            E L ++MELA+ G L   L K  H  +    EL++Q + G+ Y+ E N +HRD+AARN 
Sbjct: 392 AENLMLVMELAELGPLHKFLQKNKHITVKNLTELVHQVSMGMKYLEEHNFVHRDLAARNV 451

Query: 255 LY 256
           L 
Sbjct: 452 LL 453



 Score = 64.6 bits (157), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 18/114 (15%), Positives = 40/114 (35%), Gaps = 11/114 (9%)

Query: 4   KDLLHQKYYHGLLPREDIQEMLNK----PGQFLLRTSEPVKGEKRQFVLSVVGEKKTSAN 59
             +    Y+ G + RE+ +  L +     G +LLR S    G    + LS+   ++    
Sbjct: 3   DKVHLLPYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLG---GYALSLSYGRQ--FY 57

Query: 60  HFVVRESDHKVY--VDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER 111
           H+ +    +  Y         T I+++N++    +             +    +
Sbjct: 58  HYTIERELNDTYAIAGGKSHRTPIDVINYHSQESDGLICLLKKPFHRPRGTEPK 111


>UniRef50_B2WR86 Fibroblast growth factor receptor A n=3 Tax=Nematostella vectensis
           RepID=B2WR86_NEMVE
          Length = 877

 Score =  222 bits (566), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 54/219 (24%), Positives = 93/219 (42%), Gaps = 30/219 (13%)

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVE 122
           +R  +      +  F + +       S  +S S           +    + WE+    + 
Sbjct: 506 IRYRNGSY---RSRFSSGV------SSRLDSSSVITEESFLDFYELPIDEDWEIDRSQIT 556

Query: 123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL- 181
           + ++LGEGAFG V K + L + D  ++   VAVK  K ++ T+ ++ +++ E   M+N+ 
Sbjct: 557 IKEQLGEGAFGLVMKAEALGLTDMPYRHT-VAVKMLKADA-TENELADLLSEMDTMKNIG 614

Query: 182 DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFP------------------MI 223
            H N++   G      PLYV++E A  G L   L +                      + 
Sbjct: 615 SHKNIINLIGACTQNGPLYVVVEFAPHGNLRQFLRERRPSDYHRSRSDSSTHSQPSLIVR 674

Query: 224 KKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                 +Q A G+ Y+  K  +HRD+AARN L G   V+
Sbjct: 675 DFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVM 713


>UniRef50_P06213 Insulin receptor subunit beta n=70 Tax=Euteleostomi RepID=INSR_HUMAN
          Length = 1382

 Score =  221 bits (564), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 55/188 (29%), Positives = 92/188 (48%), Gaps = 17/188 (9%)

Query: 86   HYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILD 145
            +  S  E  S  D    +V        +WE+  E + L ++LG+G+FG V++G    I+ 
Sbjct: 992  YASSNPEYLSASDVFPCSVYVP----DEWEVSREKITLLRELGQGSFGMVYEGNARDIIK 1047

Query: 146  ANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMEL 205
               +   VAVKT    +  +E+I E + EA +M+     +VV+  GV +  +P  V+MEL
Sbjct: 1048 GEAE-TRVAVKTVNESASLRERI-EFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMEL 1105

Query: 206  ADGGALDSALGKLH-----------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNC 254
               G L S L  L              + +  ++  + A+G+AY++ K  +HRD+AARNC
Sbjct: 1106 MAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNC 1165

Query: 255  LYGGGQVL 262
            +      +
Sbjct: 1166 MVAHDFTV 1173


>UniRef50_Q9V6K3 Tyrosine-protein kinase transmembrane receptor Ror2 n=6
           Tax=Drosophila RepID=ROR2_DROME
          Length = 724

 Score =  221 bits (563), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 58/256 (22%), Positives = 105/256 (41%), Gaps = 22/256 (8%)

Query: 23  EMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRES--DHKVYVDKIGFPTI 80
             L+K   +    S+P      +  +S+ G      N    RE+   +        + TI
Sbjct: 345 YKLSKHKDY----SQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTI 400

Query: 81  IELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKL 140
                 + +     +  + +     K     +K E    D+   + LG+GAFG V++ + 
Sbjct: 401 RSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARA 460

Query: 141 LKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLY 200
             ++  + + +LVAVK  K ++  + Q+ +  REA L+   DH N+V+  GV A   P+ 
Sbjct: 461 PGLV-PDQEDLLVAVKMLKDDASDQMQM-DFEREACLLAEFDHPNIVRLLGVCALGRPMC 518

Query: 201 VIMELADGGALDSALG--------------KLHFPMIKKYELIYQAANGLAYIHEKNLMH 246
           ++ E    G L   L               +L    +   ++    A G+ Y+ E+  +H
Sbjct: 519 LLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVH 578

Query: 247 RDVAARNCLYGGGQVL 262
           RD+A RNCL      +
Sbjct: 579 RDLATRNCLINEHMAV 594


>UniRef50_C4QEV8 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4QEV8_SCHMA
          Length = 643

 Score =  220 bits (562), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 52/209 (24%), Positives = 98/209 (46%), Gaps = 13/209 (6%)

Query: 63  VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQ-KWELYHEDV 121
           + +   +   ++       +L N +   ++    K+     +    +++   +E   +++
Sbjct: 294 INKIKERYTTNRYVSSESQQLYNRFTHEEDLQRLKELDKLFLSNYQLKKDEDYEFSRKNL 353

Query: 122 ELTKKLGEGAFGEVWKGKLLKILD--ANHQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           +LT +LG GAFG V++G    + +    ++ + VAVKT K +  T+  + E + E  +M+
Sbjct: 354 QLTCRLGSGAFGIVYRGVAENLPNCINTNEKIDVAVKTLKDD-FTEGDVSEFLMEVNIMK 412

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIKKYELIYQ 231
            L H ++++F+GV        +IME A  G L   L +            +       YQ
Sbjct: 413 QLRHKHIIEFYGVCTENGSPLLIMEYAPYGNLKEYLRRHRKIWLNCDNLSLK-LLNFGYQ 471

Query: 232 AANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
            A+G+ Y+  K L+HRD+AARN L G   
Sbjct: 472 VADGMKYLESKCLIHRDLAARNILVGKHY 500


>UniRef50_Q05397 Focal adhesion kinase 1 n=105 Tax=cellular organisms
           RepID=FAK1_HUMAN
          Length = 1052

 Score =  220 bits (562), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 60/212 (28%), Positives = 96/212 (45%), Gaps = 19/212 (8%)

Query: 61  FVVRESDHKVYVDKIGFPTIIELVN--------HYVSTKESFSTKDGTVKAVLKQAVERQ 112
           F++R         +   P+I +L N        H VS  E+    +   +         +
Sbjct: 358 FIIRPQKEG----ERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTR 413

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            +E+  E +EL + +GEG FG+V +G     +   +  + VA+KT K    +    ++ +
Sbjct: 414 DYEIQRERIELGRCIGEGQFGDVHQGIY---MSPENPALAVAIKTCK-NCTSDSVREKFL 469

Query: 173 REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKLHFPMIKKYELIY 230
           +EA  MR  DH ++VK  GV     P+++IMEL   G L S L   K    +       Y
Sbjct: 470 QEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAY 528

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           Q +  LAY+  K  +HRD+AARN L      +
Sbjct: 529 QLSTALAYLESKRFVHRDIAARNVLVSSNDCV 560


>UniRef50_Q7Q0F6 Tyrosine-protein kinase receptor n=1 Tax=Anopheles gambiae
            RepID=Q7Q0F6_ANOGA
          Length = 1318

 Score =  220 bits (561), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 53/195 (27%), Positives = 91/195 (46%), Gaps = 19/195 (9%)

Query: 84   VNHYVSTKESFSTKDGTVKAVLKQA---VERQKWELYHEDVELTKKLGEGAFGEVWKGKL 140
            V +        S      +     A    +  +WE+  E +   ++LG+G+FG V+KG +
Sbjct: 953  VYYLKHNYIPMSNMRLFAQVNPDYAGVTYKVDEWEVPREHIIQLEELGQGSFGMVYKGIM 1012

Query: 141  LKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLY 200
             K+   N   V  A+KT   E+ T+ +    + EA +M+     +VV+ +GV +  +P  
Sbjct: 1013 TKL--GNDVNVPCAIKTV-TENATERERDSFLIEATIMKEFHTHHVVRLYGVVSVGQPTL 1069

Query: 201  VIMELADGGALDSALGKLH-------------FPMIKKYELIYQAANGLAYIHEKNLMHR 247
            VIMEL   G L S L +                 + + Y++  + A+G+AY+  K  +HR
Sbjct: 1070 VIMELMANGDLKSYLRRHRPDYENGEESSPQPPTLKQIYQMAIEIADGMAYLAAKKFVHR 1129

Query: 248  DVAARNCLYGGGQVL 262
            D+AARNC+      +
Sbjct: 1130 DLAARNCMVAEDLTV 1144


>UniRef50_Q9U5A8 Tyrosine-protein kinase receptor n=4 Tax=Coelomata RepID=Q9U5A8_BOMMO
          Length = 1472

 Score =  219 bits (560), Expect = 5e-56,   Method: Composition-based stats.
 Identities = 48/189 (25%), Positives = 89/189 (47%), Gaps = 16/189 (8%)

Query: 88   VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
            +S  E+           +       +WE+  + +   ++LG+G+FG V++G   +I+   
Sbjct: 1049 MSHAEASKLFASVNPEYVPTVYVPDEWEVTRDSIHFIRELGQGSFGMVYEGIAKEIVK-G 1107

Query: 148  HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELAD 207
                  A+KT    +  +E+I E + EA +M+  D  +VV+  GV +  +P  V+MEL +
Sbjct: 1108 KPETRCAIKTVNEHATDRERI-EFLNEASVMKAFDTFHVVRLLGVVSRGQPTLVVMELME 1166

Query: 208  GGALDSALGKLHF--------------PMIKKYELIYQAANGLAYIHEKNLMHRDVAARN 253
             G L + L  +                 +    ++  + A+G+AY+  K  +HRD+AARN
Sbjct: 1167 RGDLKTYLRSMRPDAEGSLPSSPPVPPTLQNILQMAIEIADGMAYLSAKKFVHRDLAARN 1226

Query: 254  CLYGGGQVL 262
            C+  G   +
Sbjct: 1227 CMVAGDLTV 1235


>UniRef50_UPI000155484B PREDICTED: similar to type 1 IGF receptor n=1 Tax=Ornithorhynchus
           anatinus RepID=UPI000155484B
          Length = 1055

 Score =  219 bits (559), Expect = 7e-56,   Method: Composition-based stats.
 Identities = 48/164 (29%), Positives = 85/164 (51%), Gaps = 14/164 (8%)

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
             +WE+  E + + ++LG+G+FG V++G    ++  +     VA+KT    +  +E+I E
Sbjct: 681 PDEWEVPREKITMCRELGQGSFGMVYEGIAKGVVK-DEPETRVAIKTVNESASMRERI-E 738

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH----------- 219
            + EA +M+  +  +VV+  GV +  +P  VIMEL   G L S L  L            
Sbjct: 739 FLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTEQNNPGQA 798

Query: 220 -FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
              + K  ++  + A+G+AY++    +HRD+AARNC+      +
Sbjct: 799 PPTLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV 842


>UniRef50_Q4RXA0 Chromosome 11 SCAF14979, whole genome shotgun sequence. (Fragment)
           n=4 Tax=Euteleostomi RepID=Q4RXA0_TETNG
          Length = 1042

 Score =  219 bits (559), Expect = 7e-56,   Method: Composition-based stats.
 Identities = 46/176 (26%), Positives = 78/176 (44%), Gaps = 6/176 (3%)

Query: 89  STKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANH 148
             K   S  D  +      A+++   E+    +   K +G G FGEV++G +        
Sbjct: 650 QLKPLKSYVDPHMYEDPNIAIQKFVTEIDPSAISKQKVIGVGEFGEVFRGVMKTR---GQ 706

Query: 149 QPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADG 208
             V VA+KT K    +++Q  + + EA +M    H N++   GV    + + ++ E  D 
Sbjct: 707 GEVNVAIKTLKPG-YSEKQRLDFLSEASIMGQFSHPNIIHLEGVVTKFKHIMIVTEYMDN 765

Query: 209 GALDSAL--GKLHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           GALD+ L       P  +   ++   A G+ Y+   + +HRD+AARN L       
Sbjct: 766 GALDTYLKGRDGEIPPYQLVGMLRGIAAGMQYLSNMSYVHRDLAARNILVNSNLEC 821


>UniRef50_Q21292 Protein K07F5.4a, partially confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q21292_CAEEL
          Length = 517

 Score =  219 bits (559), Expect = 8e-56,   Method: Composition-based stats.
 Identities = 81/289 (28%), Positives = 137/289 (47%), Gaps = 38/289 (13%)

Query: 1   MTDKDLLHQKYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSVV---GEK 54
           + +  + + K YHG+  R+  ++ L    +PG FL R+     G      LSV    G+ 
Sbjct: 19  VGNSRVHNLKCYHGVRRRKKSRKNLMRGERPGTFLFRSCFVKSGVALALFLSVKVRAGDS 78

Query: 55  KTSANHFVVRESDHKVYV-------------DKIGFPTIIELVNHYVSTKESFSTKDGTV 101
             + +H+ V +   + Y+             +   FPT+ EL+ H+   + +   + G  
Sbjct: 79  DANIHHYQVEDRAGEYYLMQELMEKEELVTRESKAFPTLEELIGHFQHHRLACKIRLG-- 136

Query: 102 KAVLKQAVERQKWELYHEDVELTK--KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAK 159
                + ++R  W+L H  V      KLG G F  V++G L K      + + VA+K +K
Sbjct: 137 -----RPLKRPSWQLRHNSVVYDDTGKLGSGNFCIVYRGMLRKQ----GKIIPVAIKVSK 187

Query: 160 LESMTKEQIKE----IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL 215
                   + E    ++ EAR+M N ++INV++ +GVA    P  V ME   GG+L+ AL
Sbjct: 188 NSDKESAALMETRNLLLAEARIMMNYNNINVIRIYGVACDVPPFMVCMEFCSGGSLEDAL 247

Query: 216 GK--LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            K        ++  L+  AA G+ Y+H+K  +HRD+A+RNCL     ++
Sbjct: 248 KKYGKDMEEFERQILLIDAARGMRYLHDKKCVHRDLASRNCLISFDGIV 296


>UniRef50_C4XV92 Venus kinase receptor (Fragment) n=6 Tax=Drosophila
           RepID=C4XV92_DROMO
          Length = 1107

 Score =  219 bits (558), Expect = 9e-56,   Method: Composition-based stats.
 Identities = 53/174 (30%), Positives = 86/174 (49%), Gaps = 16/174 (9%)

Query: 101 VKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKL 160
           +     +     KWE+  ++V + ++LGEGAFG V+ G+       + +   VAVKT K 
Sbjct: 708 ISPSRNKVNTLDKWEVQKDNVVINRRLGEGAFGTVYGGEARL---DSDEWTAVAVKTLKA 764

Query: 161 ESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKL 218
              T++++ + + EA  M+  +H N++K  GV   TEP+Y IME    G L + L   + 
Sbjct: 765 GQSTEDRL-DFLAEAEAMKKFNHKNIIKLLGVCLQTEPIYTIMEFMLYGDLKTYLLARRN 823

Query: 219 ----------HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                          +        A+GLAY+ E+  +HRD+A RNCL    +V+
Sbjct: 824 MVNEKLTDESDISSKRLTMYAMDVASGLAYLAEQKYVHRDIACRNCLVNSQRVV 877


>UniRef50_Q7YT64 Tyrosine-protein kinase receptor (Fragment) n=2 Tax=Crassostrea
           gigas RepID=Q7YT64_CRAGI
          Length = 804

 Score =  219 bits (558), Expect = 9e-56,   Method: Composition-based stats.
 Identities = 47/214 (21%), Positives = 94/214 (43%), Gaps = 36/214 (16%)

Query: 70  VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGE 129
            ++ +  F  I +  +      +              +     +WE+  + ++L ++LG+
Sbjct: 297 WFIARSRFKKIPDRPDFTSINPD-------------YEHYNPDEWEVERDKIQLIRELGQ 343

Query: 130 GAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189
           G+FG V++G    +     + + VAVKT    +  +E++ E + EA  M+     +VV+ 
Sbjct: 344 GSFGMVYEGVARDLYGKGGE-IKVAVKTVNEHATYRERM-EFLSEASRMKAFSCNHVVRL 401

Query: 190 FGVAAGTEPLYVIMELADGGALDSALGKLH---------------------FPMIKKYEL 228
            GV +  +P  +IMEL + G L + L                           + +  ++
Sbjct: 402 LGVVSDGQPALLIMELMEKGDLKNFLRMHRPVEEDIDSTFAGIKEHISRTPPTIKRIIQM 461

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             + A+G+AY+ +K  +HRD+AARNC+      +
Sbjct: 462 AGEIADGMAYLADKKFVHRDLAARNCMVAEDLTV 495


>UniRef50_UPI00017B4565 UPI00017B4565 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B4565
          Length = 992

 Score =  219 bits (558), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 47/176 (26%), Positives = 78/176 (44%), Gaps = 6/176 (3%)

Query: 89  STKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANH 148
             K   +  D         AV +   E++   +   K +G G FGEV++G L        
Sbjct: 598 QLKPLKTYVDPHTYEDPNTAVMKFATEIHPSHIAKEKVIGAGEFGEVYRGILK---VPGR 654

Query: 149 QPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADG 208
           +   VA+KT K    T++Q ++ + EA +M    H N+++  GV    +   +I E  + 
Sbjct: 655 KESAVAIKTLKPG-YTEKQRQDFLSEASIMGQFAHQNIIRLEGVVTKFKHAMIITEYMEN 713

Query: 209 GALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           GALD  L      F   +   ++   A G+ Y+ + + +HRD+AARN L       
Sbjct: 714 GALDRYLRDHDGEFTSFQLVGMLRGIAAGMKYLSDMSYVHRDLAARNILVNNTLEC 769


>UniRef50_Q4S6E0 Chromosome 10 SCAF14728, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4S6E0_TETNG
          Length = 713

 Score =  218 bits (556), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 50/191 (26%), Positives = 78/191 (40%), Gaps = 20/191 (10%)

Query: 91  KESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN-HQ 149
           + S S           +     KWE     + L K LGEG FG+V     + I     ++
Sbjct: 303 RLSSSDGPMLANVSELELPPDPKWEFPRTRLTLGKPLGEGCFGQVVMADAVGIDKEKPNK 362

Query: 150 PVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADG 208
           P+ VAVK  K ++  K+ + +++ E  +M+ +  H N++   G      PLYV++E A  
Sbjct: 363 PLTVAVKMLKDDATDKD-LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASK 421

Query: 209 GALDSALGKLH-----------------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAA 251
           G L   L                               YQ A G+ Y+  +  +HRD+AA
Sbjct: 422 GNLREYLRARRPPGMDYSFDTCKIPDEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAA 481

Query: 252 RNCLYGGGQVL 262
           RN L     V+
Sbjct: 482 RNVLVTDDNVM 492


>UniRef50_Q16620 BDNF/NT-3 growth factors receptor n=90 Tax=Euteleostomi
           RepID=NTRK2_HUMAN
          Length = 822

 Score =  217 bits (555), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 48/161 (29%), Positives = 78/161 (48%), Gaps = 17/161 (10%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +   ++ L ++LGEGAFG+V+  +   +       +LVAVKT K    +    K+  REA
Sbjct: 533 IKRHNIVLKRELGEGAFGKVFLAECYNLC-PEQDKILVAVKTLKD--ASDNARKDFHREA 589

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--------------HFP 221
            L+ NL H ++VKF+GV    +PL ++ E    G L+  L                    
Sbjct: 590 ELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELT 649

Query: 222 MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             +   +  Q A G+ Y+  ++ +HRD+A RNCL G   ++
Sbjct: 650 QSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV 690


>UniRef50_UPI0000EC9DFD Insulin receptor related tyrosine kinase n=1 Tax=Gallus gallus
           RepID=UPI0000EC9DFD
          Length = 972

 Score =  217 bits (555), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 53/195 (27%), Positives = 95/195 (48%), Gaps = 20/195 (10%)

Query: 86  HYVSTKESFSTKDGTVKAVLKQ-------AVERQKWELYHEDVELTKKLGEGAFGEVWKG 138
            Y   + +     GT+ A +              +WE+  E + + ++LG+G+FG V++G
Sbjct: 603 FYNKKRSNDGYPSGTLYASVNPEYFSASDMYIPDEWEVSREKITVIRELGQGSFGMVYEG 662

Query: 139 KLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEP 198
             + ++ A  +   VA+KT    +  +E+I E ++EA +M+     +VV+  GV +  +P
Sbjct: 663 LAMGLV-AEGEETKVALKTVNELATMRERI-EFLKEASVMKAFKCHHVVRLLGVVSQGQP 720

Query: 199 LYVIMELADGGALDSALGKLH-----------FPMIKKYELIYQAANGLAYIHEKNLMHR 247
             VIMEL   G L S L  L              +    ++  + A+G+AY++ K  +HR
Sbjct: 721 ALVIMELMTRGDLKSYLRSLRPDAENNPGLPPPSLKDMIQMAGEIADGMAYLNAKKFVHR 780

Query: 248 DVAARNCLYGGGQVL 262
           D+AARNC+      +
Sbjct: 781 DLAARNCMVSEDFTV 795


>UniRef50_B4JPQ9 GH13351 n=3 Tax=Drosophila RepID=B4JPQ9_DROGR
          Length = 1165

 Score =  217 bits (555), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 51/174 (29%), Positives = 83/174 (47%), Gaps = 16/174 (9%)

Query: 101 VKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKL 160
           +     +     KWE+  E+V + ++LGEGAFG V+ G+       +     VAVKT K 
Sbjct: 761 ISPSRNKINTLDKWEVPRENVVVNRRLGEGAFGTVYGGEAK---FNSDDWTAVAVKTLKS 817

Query: 161 ESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKL 218
              T++++ + + EA  M+  +H N++K  GV    EP+Y IM+    G L + L   + 
Sbjct: 818 GGSTEDRL-DFLAEAEAMKKFNHKNIIKLLGVCLQKEPIYTIMQFMLYGDLKTYLLARRN 876

Query: 219 ----------HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                          +        A GLAY+ E+  +HRD+A RNCL    +++
Sbjct: 877 MVNEKITDESDISSKRLTMYAMDVARGLAYLAEQKYVHRDIACRNCLVDSQRMV 930


>UniRef50_P08069 Insulin-like growth factor 1 receptor beta chain n=67
            Tax=Euteleostomi RepID=IGF1R_HUMAN
          Length = 1367

 Score =  217 bits (554), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 55/220 (25%), Positives = 97/220 (44%), Gaps = 30/220 (13%)

Query: 54   KKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK 113
                   +V     +   +           V +     E FS  D  V           +
Sbjct: 949  GGLVIMLYVFHRKRNNSRLGNG--------VLYASVNPEYFSAADVYVP---------DE 991

Query: 114  WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
            WE+  E + ++++LG+G+FG V++G    ++  +     VA+KT    +  +E+I E + 
Sbjct: 992  WEVAREKITMSRELGQGSFGMVYEGVAKGVVK-DEPETRVAIKTVNEAASMRERI-EFLN 1049

Query: 174  EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-----------FPM 222
            EA +M+  +  +VV+  GV +  +P  VIMEL   G L S L  L              +
Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 1109

Query: 223  IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             K  ++  + A+G+AY++    +HRD+AARNC+      +
Sbjct: 1110 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV 1149


>UniRef50_Q2EKC1 Fibroblast growth factor receptor n=3 Tax=Eumetazoa
           RepID=Q2EKC1_BRABE
          Length = 856

 Score =  217 bits (553), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 47/169 (27%), Positives = 74/169 (43%), Gaps = 19/169 (11%)

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
              WE   + + L K LGEG FG+V     + I++       VAVK  K ++ T+ ++ +
Sbjct: 505 DPDWEFPRDRLHLGKPLGEGCFGQVVMADAVGIIEKE-TVTTVAVKMLKEDA-TERELAD 562

Query: 171 IMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---------- 219
           ++ E   M+ +  H N++   G      PL+VI+E A+ G L   L              
Sbjct: 563 LVSEMETMKRIGKHKNIINLLGCCTQDGPLFVIVEYAEHGNLRDFLRARRPPSMDYYKMA 622

Query: 220 ------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                           YQ   G+ ++H K  +HRD+AARN L   G V+
Sbjct: 623 VECDKPLTHKDLVSFAYQIGRGMEFLHSKKCIHRDLAARNVLVAEGNVM 671


>UniRef50_UPI000180B037 PREDICTED: insulin receptor, partial n=1 Tax=Ciona intestinalis
           RepID=UPI000180B037
          Length = 807

 Score =  216 bits (552), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 48/185 (25%), Positives = 91/185 (49%), Gaps = 12/185 (6%)

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
            ++K+S +      +       E  ++E+  E+VEL  ++G G FG+V++G   +++   
Sbjct: 490 HNSKKSQTYVSVNPEYSSIGVYEPDEYEIPEENVELMDEIGHGHFGKVYEGLAKQVVK-G 548

Query: 148 HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELAD 207
                VAVKT    + +  +  E ++EA +M+  +  +VV+  GV + ++   VIME   
Sbjct: 549 QPKTKVAVKTLH-GNESISKRMEFLKEASVMKAFNSHHVVRLLGVVSMSKRPMVIMEFMA 607

Query: 208 GGALDSALGKLH----------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
            G L + L                + +K ++  + A+G++Y+ E   +HRD+AARNCL  
Sbjct: 608 KGDLKTYLRSTRPDAEIRKGDPPSLQQKLQMCGEIADGMSYLSETKYVHRDLAARNCLVH 667

Query: 258 GGQVL 262
               +
Sbjct: 668 EDLTV 672


>UniRef50_C4XV89 Venus kinase receptor (Fragment) n=2 Tax=Pediculus humanus corporis
           RepID=C4XV89_9NEOP
          Length = 1154

 Score =  216 bits (552), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 53/172 (30%), Positives = 86/172 (50%), Gaps = 18/172 (10%)

Query: 105 LKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMT 164
           L   ++  KWE+  + + + +KLGEGAFG V+ G+      ++   V  AVK  K+ S T
Sbjct: 831 LAPNLDSDKWEIPRDRLVINRKLGEGAFGTVYGGEAY---FSDKGWVAAAVKALKVNSTT 887

Query: 165 KEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKL---- 218
           ++++ + + EA +M+  DH N+VK  GV    EP+Y +ME    G L + L   +     
Sbjct: 888 EQKL-DFLSEAEVMKKFDHKNIVKLLGVCTKQEPVYTVMEFMLYGDLKTFLLARRHLVNN 946

Query: 219 --------HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                        K   +    A GL+Y+ +   +HRD+A RNCL    +V+
Sbjct: 947 KKIHEESDEISSKKLTAMALDVARGLSYLAQLKYVHRDIACRNCLINYARVV 998


>UniRef50_Q05688 Insulin-like growth factor 1 receptor beta chain (Fragment) n=41
           Tax=Euteleostomi RepID=IGF1R_BOVIN
          Length = 640

 Score =  216 bits (552), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 55/220 (25%), Positives = 97/220 (44%), Gaps = 30/220 (13%)

Query: 54  KKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK 113
                  +V     +   +           V +     E FS  D  V           +
Sbjct: 222 GGLVIMLYVFHRKRNSSRLGNG--------VLYASVNPEYFSAADVYVP---------DE 264

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WE+  E + ++++LG+G+FG V++G    ++  +     VA+KT    +  +E+I E + 
Sbjct: 265 WEVAREKITMSRELGQGSFGMVYEGVAKGVVK-DEPETRVAIKTVNEAASMRERI-EFLN 322

Query: 174 EARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH-----------FPM 222
           EA +M+  +  +VV+  GV +  +P  VIMEL   G L S L  L              +
Sbjct: 323 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 382

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            K  ++  + A+G+AY++    +HRD+AARNC+      +
Sbjct: 383 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV 422


>UniRef50_Q8IXC7 Isoform of FGFR2 n=10 Tax=Euteleostomi RepID=Q8IXC7_HUMAN
          Length = 709

 Score =  216 bits (552), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 50/173 (28%), Positives = 76/173 (43%), Gaps = 20/173 (11%)

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN-HQPVLVAVKTAKLESMTKEQ 167
            E  KWE   + + L K LGEG FG+V   + + I      + V VAVK  K ++ T++ 
Sbjct: 357 PEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA-TEKD 415

Query: 168 IKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH------- 219
           + +++ E  +M+ +  H N++   G      PLYVI+E A  G L   L           
Sbjct: 416 LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 475

Query: 220 ----------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                               YQ A G+ Y+  +  +HRD+AARN L     V+
Sbjct: 476 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 528


>UniRef50_P21802 Fibroblast growth factor receptor 2 n=316 Tax=Euteleostomi
           RepID=FGFR2_HUMAN
          Length = 821

 Score =  216 bits (552), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 50/173 (28%), Positives = 76/173 (43%), Gaps = 20/173 (11%)

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN-HQPVLVAVKTAKLESMTKEQ 167
            E  KWE   + + L K LGEG FG+V   + + I      + V VAVK  K ++ T++ 
Sbjct: 469 PEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA-TEKD 527

Query: 168 IKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH------- 219
           + +++ E  +M+ +  H N++   G      PLYVI+E A  G L   L           
Sbjct: 528 LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 587

Query: 220 ----------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                               YQ A G+ Y+  +  +HRD+AARN L     V+
Sbjct: 588 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 640


>UniRef50_B7Q0S4 Tyrosine-protein kinase receptor n=1 Tax=Ixodes scapularis
           RepID=B7Q0S4_IXOSC
          Length = 829

 Score =  216 bits (552), Expect = 6e-55,   Method: Composition-based stats.
 Identities = 53/166 (31%), Positives = 79/166 (47%), Gaps = 19/166 (11%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+    V   ++LGEGAFG+V++G+LL +      P+ VA+KT K  +  K Q ++  RE
Sbjct: 474 EVPSPQVRFLQELGEGAFGKVYRGELLPVKRDCSLPIQVAIKTLKENAAMKTQ-QDFQRE 532

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH---------FPMIKK 225
           A LM +L H N+V   GV    EPL ++ E    G L   L +             +   
Sbjct: 533 AELMSDLQHPNIVCLLGVCTKEEPLCMLFEYMPHGDLHEFLVQHSPRCEGTTQVLDLADF 592

Query: 226 YELIYQ---------AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             +  Q          A G+ Y+   + +HRD+AARNCL G    +
Sbjct: 593 LHISRQASQSINAFFVAAGMEYLSAHHYVHRDLAARNCLVGESLTV 638


>UniRef50_Q4SMF1 Chromosome 8 SCAF14552, whole genome shotgun sequence. (Fragment)
           n=13 Tax=Clupeocephala RepID=Q4SMF1_TETNG
          Length = 714

 Score =  216 bits (551), Expect = 6e-55,   Method: Composition-based stats.
 Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 7/182 (3%)

Query: 84  VNHYVSTKESFSTK-DGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLK 142
           +  Y+S +       D +      +AV+    E+    +++ + +G   FGEV +G+   
Sbjct: 315 LQRYISNRGGVKYYVDPSTYEDPSEAVKEFAREIDPTHLKIEEVIGAAQFGEVSRGRYRP 374

Query: 143 ILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVI 202
           +     + VLVAVKT +  +  +E+    + EA ++   DH NV+K  GV   T P  ++
Sbjct: 375 L---GRREVLVAVKTLRWGASDREKGM-FLSEAGVLGQFDHPNVLKLEGVITRTPPERIV 430

Query: 203 MELADGGALDSALGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
            E  + G LDS L +    F +++   ++     G+ Y+ E+N +HRD+AARN L     
Sbjct: 431 TEFMENGPLDSFLRENEGQFSVLQLVGMLRGIGAGMRYLAERNFVHRDLAARNVLVNSNL 490

Query: 261 VL 262
           V 
Sbjct: 491 VC 492


>UniRef50_Q17JW1 Tyrosine protein kinase n=2 Tax=Culicini RepID=Q17JW1_AEDAE
          Length = 722

 Score =  216 bits (551), Expect = 6e-55,   Method: Composition-based stats.
 Identities = 52/173 (30%), Positives = 83/173 (47%), Gaps = 16/173 (9%)

Query: 102 KAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLE 161
                      KWE+  + V + ++LGEGAFG V+ G+       +     VAVKT K+ 
Sbjct: 274 SPSSIPVNTLDKWEVPKDRVVINRRLGEGAFGTVYGGEA---QIGDEGWTAVAVKTLKIG 330

Query: 162 SMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKL- 218
           S T++++ + + EA  M+  DH N+VK  GV   TEP+Y IME    G L + L   +  
Sbjct: 331 STTEDKV-DFLSEAEAMKRFDHNNIVKLLGVCLQTEPVYTIMEFMLYGDLKTYLLARRHL 389

Query: 219 ---------HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                         +   +    +  L+Y+ E+  +HRD+A RNC+    +V+
Sbjct: 390 VNSKQSEDSDISPKRLTMMALDVSRALSYLAEQKYVHRDLACRNCMVNAQRVV 442


>UniRef50_UPI0001A2C9CC UPI0001A2C9CC related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2C9CC
          Length = 388

 Score =  216 bits (551), Expect = 6e-55,   Method: Composition-based stats.
 Identities = 60/268 (22%), Positives = 106/268 (39%), Gaps = 34/268 (12%)

Query: 11  YYHGLL-PREDIQEML----NKPGQFLLRTSEPVKGEKRQFVLSVVGEK---KTSANHFV 62
           +Y   +  R + +  L    NK G FL+   +    E   + LS    K      A H+ 
Sbjct: 1   WYFENVKTRVEAKRCLLRPENKEGAFLVWKCD----ENNHYYLSGKVHKVKNGPHARHYR 56

Query: 63  VRESDHK---VYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVER-----QKW 114
           +++ ++      V    F ++ +L+  Y   +     K       L Q V +      K 
Sbjct: 57  IKQGENDQQFFLVHHTTFQSLRKLIEFYSKHEGGLCAKLHEACVKLDQPVPQTLSFDSKC 116

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E+    +   +KLG G F +VW+G         +    VA+K  K   M      +I  E
Sbjct: 117 EIDRSSLTKQQKLGSGEFADVWQGLW-------NNTTEVAIKEFK--GMGGVNYSDIQTE 167

Query: 175 ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH----FPMIKKYELIY 230
             +M++L H  ++K + V   ++P+ ++ EL   G+L + L +             +   
Sbjct: 168 IEIMKDLHHERLLKLYAVCTTSQPMCIVTELMKNGSLKTFLLRHKEKQDLEFSLMLDFAI 227

Query: 231 QAANGLAYIHEKNLMHRDVAARNCLYGG 258
           Q   G+ YI    ++HRD+ A N L   
Sbjct: 228 QITEGMIYIE-NKIVHRDLRAENILLTE 254


>UniRef50_UPI0001926939 PREDICTED: similar to eph receptor A7 n=4 Tax=Hydra magnipapillata
           RepID=UPI0001926939
          Length = 838

 Score =  216 bits (551), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 60/216 (27%), Positives = 97/216 (44%), Gaps = 20/216 (9%)

Query: 46  FVLSVVGEKKTSANHFV-VRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAV 104
           F+L +   KK    +F  VR  D  V +    F +            +     D T    
Sbjct: 403 FILGLYIWKKRHPMYFQAVRMEDGTVKLPSGPFKS------------QGKVYVDPTTYKD 450

Query: 105 LKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMT 164
           +  AVE   +EL  +D++    LG G F EV+KG LL+    + +P+ VA+K  K  + +
Sbjct: 451 VDDAVEEFAYELERKDLKFGTLLGGGEFAEVYKGTLLR----DGKPIDVAIKILKNGA-S 505

Query: 165 KEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPM 222
           K    + + EA ++      NV+   GV    +P  +++E    GALD  L +    F  
Sbjct: 506 KHDRDDFLGEAAILGQFADQNVICLEGVILRDKPNLIVLEYMANGALDKFLQENDNQFTT 565

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
           ++   +    A+G+ Y+ E   +HRD+AARN L   
Sbjct: 566 LQLLGMARGVASGMKYLSEMGFIHRDLAARNILVDE 601


>UniRef50_B8JIA2 Fibroblast growth factor receptor 3 (Fragment) n=4 Tax=Coelomata
           RepID=B8JIA2_DANRE
          Length = 497

 Score =  216 bits (550), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 51/191 (26%), Positives = 78/191 (40%), Gaps = 20/191 (10%)

Query: 91  KESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN-HQ 149
           + S S           +     KWE     + L K LGEG FG+V   + + I     ++
Sbjct: 127 RLSSSDGPMLPNVSELELPSDPKWEFTRTKLTLGKPLGEGCFGQVVMAEAIGIDKEKPNK 186

Query: 150 PVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADG 208
           P+ VAVK  K +   K+ + +++ E  +M+ +  H N++   G      PLYV++E A  
Sbjct: 187 PLTVAVKMLKDDGTDKD-LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASK 245

Query: 209 GALDSALGKLH-----------------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAA 251
           G L   L                               YQ A G+ Y+  K  +HRD+AA
Sbjct: 246 GNLREYLRARRPPGMDYSFDTCKIPNETLTFKDLVSCAYQVARGMEYLASKKCIHRDLAA 305

Query: 252 RNCLYGGGQVL 262
           RN L     V+
Sbjct: 306 RNVLVTEDNVM 316


>UniRef50_C4XV88 Venus kinase receptor (Fragment) n=3 Tax=Coelomata RepID=C4XV88_STRPU
          Length = 1566

 Score =  216 bits (550), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 54/165 (32%), Positives = 85/165 (51%), Gaps = 18/165 (10%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             +WE+  E+V L +KLGEGAFG V+ G+    L  +++   VAVKT KL +  +E++ + 
Sbjct: 1011 DEWEMPRENVVLNRKLGEGAFGTVYGGEA---LLDDNKWAAVAVKTLKLGASVEEKL-DF 1066

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL-------------GKL 218
            + EA +M+  +H N+V   GV    EP+Y +ME    G L + L                
Sbjct: 1067 LSEAEVMKRFNHKNIVNLLGVCTRGEPMYAVMEFMLYGDLKTFLLGRRHLVGEGVYERNQ 1126

Query: 219  HFP-MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            H     +   ++   A+GL+Y+   N +HRD+A RNCL      +
Sbjct: 1127 HVMCPDQLTSMVSDIASGLSYLASINYVHRDLACRNCLVDASYTV 1171


>UniRef50_P14616 Insulin receptor-related protein beta chain n=11 Tax=Eutheria
            RepID=INSRR_HUMAN
          Length = 1297

 Score =  215 bits (549), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 48/188 (25%), Positives = 86/188 (45%), Gaps = 13/188 (6%)

Query: 86   HYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILD 145
            +      +                   +WE+  E + + ++LG+G+FG V++G    + +
Sbjct: 944  YGKKRNRTLYASVNPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGL-E 1002

Query: 146  ANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMEL 205
            A  +   VA+KT    +  +E I E ++EA +M+     +VV+  GV +  +P  VIMEL
Sbjct: 1003 AGEESTPVALKTVNELASPRECI-EFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMEL 1061

Query: 206  ADGGALDSALGKLHFP-----------MIKKYELIYQAANGLAYIHEKNLMHRDVAARNC 254
               G L S L  L              + +  ++  + A+G+AY+     +HRD+AARNC
Sbjct: 1062 MTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNC 1121

Query: 255  LYGGGQVL 262
            +      +
Sbjct: 1122 MVSQDFTV 1129


>UniRef50_P29322 Ephrin type-A receptor 8 n=37 Tax=Coelomata RepID=EPHA8_HUMAN
          Length = 1005

 Score =  215 bits (548), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 46/208 (22%), Positives = 79/208 (37%), Gaps = 23/208 (11%)

Query: 74  KIGFPTIIELVNHYVSTKESFSTKDG-----------------TVKAVLKQAVERQKWEL 116
              F    E   HY + +                                +A      E+
Sbjct: 571 SKAFQDSDEEKMHYQNGQAPPPVFLPLHHPPGKLPEPQFYAEPHTYEEPGRAGRSFTREI 630

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
               + + K +G G  GEV  G+L        + V VA+K  K    T+ Q ++ + EA 
Sbjct: 631 EASRIHIEKIIGSGDSGEVCYGRLR---VPGQRDVPVAIKALKAG-YTERQRRDFLSEAS 686

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--HFPMIKKYELIYQAAN 234
           +M   DH N+++  GV        ++ E  + G+LD+ L      F +++   ++     
Sbjct: 687 IMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGA 746

Query: 235 GLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           G+ Y+ +   +HRD+AARN L     V 
Sbjct: 747 GMRYLSDLGYVHRDLAARNVLVDSNLVC 774


>UniRef50_Q8JG38 Fibroblast growth factor receptor 2 n=25 Tax=Euteleostomi
           RepID=FGFR2_DANRE
          Length = 817

 Score =  215 bits (548), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 54/193 (27%), Positives = 84/193 (43%), Gaps = 23/193 (11%)

Query: 89  STKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN- 147
           +T+ S +  D   +  L    E  +WE   + + L K LGEG FG+V   + L I     
Sbjct: 448 TTRRSSAHDDPIPEYDLP---EDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKP 504

Query: 148 HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELA 206
            + V VAVK  K ++ T++ + +++ E  +M+ +  H N++   G      PLYVI+E A
Sbjct: 505 KEAVTVAVKMLKDDA-TEKDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYA 563

Query: 207 DGGALDSALGKLH-----------------FPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
             G L   L                               YQ A G+ Y+  +  +HRD+
Sbjct: 564 SKGNLREYLRARRPPGMEYSYDIARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDL 623

Query: 250 AARNCLYGGGQVL 262
           AARN L     V+
Sbjct: 624 AARNVLVTESNVM 636


>UniRef50_Q0P4R9 Discoidin domain receptor family, member 2 n=5 Tax=Euteleostomi
           RepID=Q0P4R9_XENTR
          Length = 879

 Score =  214 bits (547), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 22/169 (13%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKI--------LDANHQPVLVAVKTAKLESMTKE 166
           E     + L +KLGEG FGEV   +   +         + + QP +VAVK  + + +TK 
Sbjct: 579 EFPRNQLRLKEKLGEGQFGEVHLCEAEGLQEFLEMSPNEFSDQPNMVAVKMLRPD-VTKT 637

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHF------ 220
              + ++E +++  L H N+++  GV    +PL +I E  + G L+  L +         
Sbjct: 638 ARNDFLKEIKIISRLKHPNIIRLLGVCVRDDPLCMITEYMENGDLNQFLSQREIRSQFTK 697

Query: 221 -------PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                         +  Q A G+ Y+   N +HRD+A RNCL G    +
Sbjct: 698 ANNIPSVSRQNLLYMAAQIAAGMKYLASLNFVHRDLATRNCLVGNSYTI 746


>UniRef50_C5H7S1 Venus kinase receptor n=3 Tax=Culicidae RepID=C5H7S1_ANOGA
          Length = 1465

 Score =  214 bits (547), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 50/163 (30%), Positives = 83/163 (50%), Gaps = 16/163 (9%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             KWE+  + V + ++LGEGAFG V+ G+       +     VAVKT K+ S T++++ + 
Sbjct: 945  DKWEIPKDRVVINRRLGEGAFGTVYGGEA---QIGDEGWTAVAVKTLKVGSTTEDKV-DF 1000

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKL----------H 219
            + EA  M+  DH N+V+  GV   +EP+Y +ME    G L + L   +            
Sbjct: 1001 LSEAEAMKRFDHNNIVRLLGVCLQSEPVYTVMEFMLYGDLKTYLLARRHLVNSKQSEDSD 1060

Query: 220  FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                +   +    +  L+Y+ E+  +HRDVA RNC+    +V+
Sbjct: 1061 ISNKRLTVMALDVSRALSYLAEQKYVHRDVACRNCMVNAQRVV 1103


>UniRef50_P09208 Insulin-like receptor subunit beta 2 n=48 Tax=Coelomata
            RepID=INSR_DROME
          Length = 2144

 Score =  214 bits (547), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 58/271 (21%), Positives = 93/271 (34%), Gaps = 47/271 (17%)

Query: 27   KPGQFLLRTSEPVKGEKRQFVLSVVGEKKTSANHFVVRESDH--KVYVD----KIGFPTI 80
              G +  R           F             H  V       KV+       + F  I
Sbjct: 1275 NEGLYSFRVRANSIAGYGDFT---------EVEHIKVEPPPSYAKVFFWLLGIGLAFL-I 1324

Query: 81   IELVNH--YVSTK----ESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGE 134
            + L  +  Y+  +                          WE+  E++     LG+G+FG 
Sbjct: 1325 VSLFGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGM 1384

Query: 135  VWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAA 194
            V++G L      N      A+KT    +  +E     + EA +M+  D  +VV+  GV +
Sbjct: 1385 VYEGILK-SFPPNGVDRECAIKTVNENATDRE-RTNFLSEASVMKEFDTYHVVRLLGVCS 1442

Query: 195  GTEPLYVIMELADGGALDSALGKLHFPMIK-----------------------KYELIYQ 231
              +P  V+MEL   G L S L                                 Y++  +
Sbjct: 1443 RGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIE 1502

Query: 232  AANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             A+G+AY+  K  +HRD+AARNC+      +
Sbjct: 1503 IADGMAYLAAKKFVHRDLAARNCMVADDLTV 1533


>UniRef50_C9DED1 Fibroblast growth factor receptor B n=1 Tax=Saccoglossus
           kowalevskii RepID=C9DED1_SACKO
          Length = 928

 Score =  214 bits (547), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 57/247 (23%), Positives = 101/247 (40%), Gaps = 32/247 (12%)

Query: 46  FVLSVVGEKKTSANHFVVRESDHKVYVDKIGFP-----TIIELVNHYVSTKESFSTKDGT 100
             + V G+K+      V+ E+    +VD          T+         ++         
Sbjct: 456 IFVCVRGKKRKVVKSAVIVENGLYHFVDSRTERPHLRRTLSGSSTGSSGSQAPLLRFRSQ 515

Query: 101 VKAVLKQAVERQ-----KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAV 155
           + + L    E +      WE+  + +EL + LGEGAFG+V K +   I   + +   VAV
Sbjct: 516 LSSSLTILSEYEVPCDPDWEIPRDKLELKEPLGEGAFGQVIKAEAKGIFGKD-KTTTVAV 574

Query: 156 KTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           K  K+ + T+ ++ +++ E  +M+ +  H+N++   G +    PLYV++E A  G L   
Sbjct: 575 KMLKVSA-TERELSDLVHEMEMMKTIGKHLNIINLIGCSTQDGPLYVVVEFAPHGNLRDF 633

Query: 215 LGKLHFPMIK-------------------KYELIYQAANGLAYIHEKNLMHRDVAARNCL 255
           L     P                           YQ A  + ++  K  +HRD+AARN L
Sbjct: 634 LRSKRPPNPDYDCEKTRLVNNYEPLLNKHLVSFAYQIAKAMEFLSSKRCIHRDLAARNVL 693

Query: 256 YGGGQVL 262
                ++
Sbjct: 694 VAENNIM 700


>UniRef50_Q59FL9 Fibroblast growth factor receptor 3 isoform 1 variant (Fragment)
           n=14 Tax=Mammalia RepID=Q59FL9_HUMAN
          Length = 879

 Score =  214 bits (547), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 50/173 (28%), Positives = 75/173 (43%), Gaps = 20/173 (11%)

Query: 109 VERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANH-QPVLVAVKTAKLESMTKEQ 167
               KWEL    + L K LGEG FG+V   + + I      +PV VAVK  K ++  K+ 
Sbjct: 548 PADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD- 606

Query: 168 IKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH------- 219
           + +++ E  +M+ +  H N++   G      PLYV++E A  G L   L           
Sbjct: 607 LSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYS 666

Query: 220 ----------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                               YQ A G+ Y+  +  +HRD+AARN L     V+
Sbjct: 667 FDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVM 719


>UniRef50_Q4H3B8 Tyrosine-protein kinase receptor n=2 Tax=Ciona intestinalis
           RepID=Q4H3B8_CIOIN
          Length = 465

 Score =  214 bits (546), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 48/185 (25%), Positives = 91/185 (49%), Gaps = 12/185 (6%)

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
            ++K+S +      +       E  ++E+  E+VEL  ++G G FG+V++G   +++   
Sbjct: 66  HNSKKSQTYVSVNPEYSSIGVYEPDEYEIPEENVELMDEIGHGHFGKVYEGLAKQVVK-G 124

Query: 148 HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELAD 207
                VAVKT    + +  +  E ++EA +M+  +  +VV+  GV + ++   VIME   
Sbjct: 125 QPKTKVAVKTLH-GNESISKRMEFLKEASVMKAFNSHHVVRLLGVVSMSKRPMVIMEFMA 183

Query: 208 GGALDSALGKLH----------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
            G L + L                + +K ++  + A+G++Y+ E   +HRD+AARNCL  
Sbjct: 184 KGDLKTYLRSTRPDAEIRKGDPPSLQQKLQMCGEIADGMSYLSETKYVHRDLAARNCLVH 243

Query: 258 GGQVL 262
               +
Sbjct: 244 EDLTV 248


>UniRef50_B0XH62 Fibroblast growth factor receptor 3 n=1 Tax=Culex quinquefasciatus
           RepID=B0XH62_CULQU
          Length = 589

 Score =  214 bits (546), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 16/203 (7%)

Query: 74  KIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFG 133
            I F  +  ++  Y   K + +     ++     +    +WE   E + + ++LGEGAFG
Sbjct: 234 GIVFLAMAIVITIYKCRKGNVTILKNMLRPPAAISFTESEWEFDREKLTMEEQLGEGAFG 293

Query: 134 EVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGV 192
            V+  +   ++  +     VAVK  K    T   +K+++ E  +M+ +  H N++   G 
Sbjct: 294 RVFSAQAQDLI-PDESTTKVAVKILKENH-TGSDVKDLLDELEVMKKVCRHPNIINLLGC 351

Query: 193 AAGTEPLYVIMELADGGALDSALGKLH-------------FPMIKKYELIYQAANGLAYI 239
                PL+VI+E A  G L   L                     +     +Q A G+ ++
Sbjct: 352 CTKDGPLFVIVEYARYGNLKDFLRDHRPNVGGIKPDESYVLSNDQLISFAHQIAFGMEHL 411

Query: 240 HEKNLMHRDVAARNCLYGGGQVL 262
                +HRD+AARN L      +
Sbjct: 412 SSVKCIHRDLAARNVLVSDALTM 434


>UniRef50_C5H7S0 Venus kinase receptor (Fragment) n=2 Tax=Apis mellifera
            RepID=C5H7S0_APIME
          Length = 1238

 Score =  214 bits (546), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 17/164 (10%)

Query: 112  QKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEI 171
             KWE+    V + +KLGEGAFG V+ G+           + VAVKT K+ S T+E++ + 
Sbjct: 868  DKWEIPRHRVVINRKLGEGAFGTVYGGEA---FFPEKGWLAVAVKTLKIGSSTEEKL-DF 923

Query: 172  MREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL--GKL----------- 218
            + E  +M+  +H N++K  GV   +EP+  +ME    G L + L   +            
Sbjct: 924  LSEVEVMKQFEHKNIIKLLGVCIKSEPVLTVMEFMLYGDLKTYLLARRHLVNDNSYEDSD 983

Query: 219  HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                 K   +    A  L+Y+ +   +HRD+A+RNCL    +V+
Sbjct: 984  EISNKKLTAMALDVARALSYLAQSKYVHRDIASRNCLVNAQRVV 1027


>UniRef50_A3KPS2 Tyrosine-protein kinase receptor (Fragment) n=11 Tax=Clupeocephala
           RepID=A3KPS2_DANRE
          Length = 853

 Score =  214 bits (546), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 47/163 (28%), Positives = 81/163 (49%), Gaps = 19/163 (11%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +   ++ L ++LGEGAFG+V+  +   +   + + +LVAVKT K    ++    +  REA
Sbjct: 562 IKRHNILLKRELGEGAFGKVFLAECYNL-SPDQEKILVAVKTLKE--ASESGRADFHREA 618

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL----------------H 219
            L+ NL H ++VKF+GV   ++PL ++ E    G L+  L                    
Sbjct: 619 ELLTNLQHEHIVKFYGVCVESDPLIMVFEYMKHGDLNKFLRAHGPDAVLMADGQQSLLVE 678

Query: 220 FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
               +   +  Q A G+ Y+  ++ +HRD+A RNCL G   ++
Sbjct: 679 LTQPQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV 721


>UniRef50_Q2LC18 Tyrosine-protein kinase receptor (Fragment) n=2
           Tax=Strongylocentrotus purpuratus RepID=Q2LC18_STRPU
          Length = 1072

 Score =  214 bits (545), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 52/193 (26%), Positives = 94/193 (48%), Gaps = 20/193 (10%)

Query: 80  IIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGK 139
           + + V +     E  ST D  V           +WE   + +E+ ++LG+G+FG V++G 
Sbjct: 667 MPDGVLYASVNPEYMSTSDMYVA---------DEWEFPRDKLEIIRELGKGSFGMVYEGL 717

Query: 140 LLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPL 199
              IL    +   VA+K+ +  +  +++I E + EA +M+ +D  NVV+  GV +  +P 
Sbjct: 718 AKGILPEEEEISRVAIKSVQANASMRDRI-EFLNEASVMKLIDAHNVVRLLGVVSKGQPT 776

Query: 200 YVIMELADGGALDSALGKLH----------FPMIKKYELIYQAANGLAYIHEKNLMHRDV 249
           YVIME    G L + L                + +   +  + A+G++++  +  +HRD+
Sbjct: 777 YVIMEFMAQGDLKNWLRARRPENQQDLPSVPTLEQLLNMAAEIADGMSFLAARKYVHRDL 836

Query: 250 AARNCLYGGGQVL 262
           +ARNCL  G    
Sbjct: 837 SARNCLVSGEGTC 849


>UniRef50_UPI000186EA5D proto-oncogene receptor tyrosine protein kinase ret, putative n=1
           Tax=Pediculus humanus corporis RepID=UPI000186EA5D
          Length = 870

 Score =  213 bits (544), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 22/172 (12%)

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
            +KWE     + + + LGEG FG+V K K   I         VAVKT K ++  + ++ +
Sbjct: 446 DKKWEFPRYRLTIEEILGEGEFGKVLKAKADGIGGNPG-STTVAVKTLKDDAK-ETELSD 503

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTE-PLYVIMELADGGALDSALGKLH---------- 219
           +M E +L++++DH NV+   G    ++ P+Y+I+E A  G+L + L K            
Sbjct: 504 LMSEYQLLKDIDHPNVIHLLGACTKSDGPVYIIIEYAKHGSLRNYLRKHRAAIIEQLNHN 563

Query: 220 ---------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                              +Q A G+ Y+ +  L+HRD+AARN L   G + 
Sbjct: 564 DNNMGVEKNVTPKDLLTFAWQIAKGMNYLTDMKLVHRDLAARNILVAEGLIC 615


>UniRef50_UPI000175802D PREDICTED: similar to leukocyte receptor tyrosine protein kinase
           n=1 Tax=Tribolium castaneum RepID=UPI000175802D
          Length = 1282

 Score =  213 bits (544), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 51/163 (31%), Positives = 80/163 (49%), Gaps = 13/163 (7%)

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
           +   ++  E + L K LG+GAFGEV++G   +    +   + VAVKT   E  T +   +
Sbjct: 808 KDLKDIPREQLRLVKALGQGAFGEVYQGFYRQ-RPCDTVEMPVAVKTL-PEMSTSQAEMD 865

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPM 222
            + EA +M   +H N+V F GV     P ++++EL  GG L + L +            M
Sbjct: 866 FLMEALIMSKFNHPNIVHFIGVCFDKHPRFIVLELLAGGDLKNFLRESRPKPERGSPLTM 925

Query: 223 IKKYELIYQAANGLAYIHEKNLMHRDVAARNCLY---GGGQVL 262
                +    A G  Y+ +   +HRD+AARNCL    G G+V+
Sbjct: 926 KDLVLIAVDVAKGCKYLEDNRFIHRDIAARNCLLTTKGPGRVV 968


>UniRef50_P07949 Proto-oncogene tyrosine-protein kinase receptor Ret n=73
           Tax=Eumetazoa RepID=RET_HUMAN
          Length = 1114

 Score =  213 bits (544), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 58/249 (23%), Positives = 103/249 (41%), Gaps = 40/249 (16%)

Query: 45  QFVLSVV-GEKKTSANHF-----VVRESDHKVYVDKIGFPTIIELVNHYVS--TKESFST 96
            F++SV+         H       +  ++         FP     V++  S   + S  +
Sbjct: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP-----VSYSSSGARRPSLDS 699

Query: 97  KDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVK 156
            +  V     + +E  KWE   +++ L K LGEG FG+V K      L        VAVK
Sbjct: 700 MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF-HLKGRAGYTTVAVK 758

Query: 157 TAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG 216
             K  + +  ++++++ E  +++ ++H +V+K +G  +   PL +I+E A  G+L   L 
Sbjct: 759 MLKENA-SPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLR 817

Query: 217 KLH-------------------------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAA 251
           +                             M       +Q + G+ Y+ E  L+HRD+AA
Sbjct: 818 ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAA 877

Query: 252 RNCLYGGGQ 260
           RN L   G+
Sbjct: 878 RNILVAEGR 886


>UniRef50_UPI00004D7E5F Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1)
           (C- mer) (Receptor tyrosine kinase MerTK). n=2
           Tax=Euteleostomi RepID=UPI00004D7E5F
          Length = 763

 Score =  213 bits (543), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 56/228 (24%), Positives = 99/228 (43%), Gaps = 24/228 (10%)

Query: 47  VLSVVGEKKTSANHFVVRESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLK 106
           V+ +  +K+T   H  +   D  + V+     +       Y       +     +   L+
Sbjct: 406 VMCLRRKKETEFGHAFIHSEDSDIVVNFKAKKS-------YNRRAIEITLSTLGINQDLQ 458

Query: 107 QAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKE 166
           Q  + +   +    + L K LGEG FG V +G+L     ++     VAVKT K+++ ++ 
Sbjct: 459 Q--KLEDVMVERNLLNLGKVLGEGEFGSVMEGEL---QYSDGTNHKVAVKTMKMDNFSQR 513

Query: 167 QIKEIMREARLMRNLDHINVVKFFGVAAGTEP-----LYVIMELADGGALDSALGKLHF- 220
           +I+E + EA  M++ +H NV++  GV     P       VI+     G L S L      
Sbjct: 514 EIEEFLSEAACMKDFNHPNVIRLLGVCLEVGPRRIPKPMVILPFMKYGDLHSFLLSSRIG 573

Query: 221 ------PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                 P+    + +   A G+ Y+  +N +HRD+AARNC+      +
Sbjct: 574 SGPQHVPLRTLVKFMIDIATGMEYLSSRNFLHRDLAARNCMLRDDMTV 621


>UniRef50_UPI0001923CA2 PREDICTED: similar to predicted protein n=1 Tax=Hydra
           magnipapillata RepID=UPI0001923CA2
          Length = 545

 Score =  213 bits (543), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 55/251 (21%), Positives = 93/251 (37%), Gaps = 38/251 (15%)

Query: 48  LSVVGEKKTSANHFVVRE------SDHKVYVDKIGF--PTII---------ELVNHYVS- 89
           LS++   + S  H  +++      +          F    +           L NHY   
Sbjct: 25  LSLLNNPELSHYHTAIKKRCNDAMTPIHYLATNPRFLGKNLPIENEDEAEEWLYNHYPDF 84

Query: 90  TKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQ 149
            +    T D     +     +  +WE   E + +T  LG GAFG V  G    I +  + 
Sbjct: 85  IRSILPTTDINSFELESIFYDSDEWEFPREKLVITSVLGAGAFGIVMSGIARGI-EGTND 143

Query: 150 PVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADG 208
            V VAVK  + +   +   K+++ E  L++ + +H NV++  G     +PLYVI+E    
Sbjct: 144 EVKVAVKIVR-DHSNEAAKKDLLAELNLLKMIPEHENVIRLLGCCTRQDPLYVIVEFCAN 202

Query: 209 GALDSALGKLH-----------------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAA 251
           G L   L                            +   Q   G++ +    ++HRD+AA
Sbjct: 203 GDLQGLLRSSRGIYERYYKTCYGGSVPSLTSKMLLKFALQICKGMSQLSSMKVIHRDLAA 262

Query: 252 RNCLYGGGQVL 262
           RN L     + 
Sbjct: 263 RNVLVDENLIC 273


>UniRef50_C4Q5Z3 Ephrin receptor, putative n=1 Tax=Schistosoma mansoni
           RepID=C4Q5Z3_SCHMA
          Length = 1148

 Score =  213 bits (543), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 45/177 (25%), Positives = 86/177 (48%), Gaps = 8/177 (4%)

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
            ST    +  D +   V  +   +   E+    + +   +GEG FG+V  G    I    
Sbjct: 684 HSTPLKSTMCDSSQPPVSIRETNK---EIDPRRIMIRSTIGEGEFGKVCAGDF--ITTDE 738

Query: 148 HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELAD 207
           ++  LVA+K    + ++++  ++ + EA ++  LDH N+V+  G+   +EP  +++E  +
Sbjct: 739 NKVQLVAIKMLHPD-VSEKTRQDFLTEANILSQLDHPNIVQLIGLVIKSEPKMIVIEFME 797

Query: 208 GGALDSALGK--LHFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            G+LD+ L +      M +   ++   A G+ Y+   N +HRD+AARN L     + 
Sbjct: 798 NGSLDNYLRRNGNTLSMEQLLYMLRDIACGMNYLSHLNYVHRDLAARNILVDKFNIC 854


>UniRef50_Q1JUB8 Fibroblast growth factor receptor n=3 Tax=Endopterygota
           RepID=Q1JUB8_BOMMO
          Length = 856

 Score =  213 bits (543), Expect = 6e-54,   Method: Composition-based stats.
 Identities = 53/168 (31%), Positives = 72/168 (42%), Gaps = 20/168 (11%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            WE+  E + L K LGEG FG+V K + + IL    Q V VAVK  K      E +  ++
Sbjct: 532 DWEVPRESLSLGKVLGEGEFGKVVKAECIGILKPGLQSV-VAVKMLKEGHTDAEMMA-LV 589

Query: 173 REARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH------------ 219
            E  +M+ +  H+N++   G      PLYVI+E A  G L   L                
Sbjct: 590 SEMEMMKMIGKHVNIINLLGCCTQDGPLYVIVEYAPNGNLREFLRNHRPGNRYESPNEDL 649

Query: 220 -----FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                          YQ A G+ Y+  +  +HRD AARN L     VL
Sbjct: 650 KEKKTLTQKDLVSFSYQVARGMEYLASRRCIHRDSAARNVLVSDDCVL 697


>UniRef50_P00529 Tyrosine-protein kinase transforming protein ros n=12 Tax=root
           RepID=ROS_AVISU
          Length = 402

 Score =  212 bits (542), Expect = 7e-54,   Method: Composition-based stats.
 Identities = 56/153 (36%), Positives = 77/153 (50%), Gaps = 9/153 (5%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
              + + L K LG GAFGEV++G  L IL        VAVKT K  +  +E+  E ++EA
Sbjct: 93  FPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEK-SEFLKEA 151

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSAL---GKLHFPMI-----KKYE 227
            LM   DH +++K  GV    EP Y+I+EL +GG L S L    K  F           +
Sbjct: 152 HLMSKFDHPHILKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLD 211

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQ 260
           +      G  Y+ +   +HRD+AARNCL    Q
Sbjct: 212 ICLDICKGCVYLEKMRFIHRDLAARNCLVSEKQ 244


>UniRef50_Q7QIP0 AGAP006988-PA n=5 Tax=Endopterygota RepID=Q7QIP0_ANOGA
          Length = 699

 Score =  212 bits (542), Expect = 8e-54,   Method: Composition-based stats.
 Identities = 52/199 (26%), Positives = 87/199 (43%), Gaps = 30/199 (15%)

Query: 78  PTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWK 137
             +   VN++ +  +                 + +K E    ++   K LG+GAFG V++
Sbjct: 387 NKLPSNVNYHRTGAQLNP--------------KLEKLEFPRNNIIYIKDLGQGAFGRVFQ 432

Query: 138 GKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTE 197
            K   ++ A     LVAVK  K E+ +++   +  REA L+   DH N+VK  GV A   
Sbjct: 433 AKAPGLV-AGEDFTLVAVKMLKDEA-SQDLQVDFEREACLLAEFDHPNIVKLLGVCAIGR 490

Query: 198 PLYVIMELADGGALDSALGKL--------------HFPMIKKYELIYQAANGLAYIHEKN 243
           P+ ++ E    G L+  L +                        + +Q A+G+ Y+ E+ 
Sbjct: 491 PMCLLFEFMARGDLNEFLRQCSPFAQQNRADSISTELSHGDLLNIAHQIASGMVYLSERK 550

Query: 244 LMHRDVAARNCLYGGGQVL 262
            +HRD+A RNCL     V+
Sbjct: 551 FVHRDLATRNCLIDDHMVV 569


>UniRef50_Q4S1S8 Chromosome undetermined SCAF14764, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4S1S8_TETNG
          Length = 635

 Score =  212 bits (542), Expect = 8e-54,   Method: Composition-based stats.
 Identities = 49/195 (25%), Positives = 84/195 (43%), Gaps = 21/195 (10%)

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQK-WELYHEDVELTKKLGEGAFGEVWKGKLLKILDA 146
             ++   +     +  V +  +     WEL  + + L K LGEG FG+V   + + +   
Sbjct: 314 RQSRLPSAATTTILPGVSEYELPYDPVWELPRDRLTLGKPLGEGCFGQVVLAEAVGLDKN 373

Query: 147 NH-QPVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIME 204
              +   VAVK  K ++ T++   +++ E  +M+ +  H N++   G      PLYV++E
Sbjct: 374 KPARVTKVAVKMLKADA-TEKDRADLISEMEMMKMIGKHKNIINLLGACTQDGPLYVLVE 432

Query: 205 LADGGALDSALGKLH-----------------FPMIKKYELIYQAANGLAYIHEKNLMHR 247
            A  G L   L                       +++     YQ A G+AY+  K  +HR
Sbjct: 433 YASKGNLRDYLRARRPAGLEYWSSSRPVSLASMEIMELVSAAYQVARGMAYLASKKCIHR 492

Query: 248 DVAARNCLYGGGQVL 262
           D+AARN L     V+
Sbjct: 493 DLAARNVLVTEDNVM 507


>UniRef50_C9DED0 Fibroblast growth factor receptor A n=2 Tax=Saccoglossus
           kowalevskii RepID=C9DED0_SACKO
          Length = 748

 Score =  212 bits (541), Expect = 8e-54,   Method: Composition-based stats.
 Identities = 50/196 (25%), Positives = 82/196 (41%), Gaps = 21/196 (10%)

Query: 87  YVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDA 146
           +   + S             +    +KWE     + + K LGEGAFG+V + + + I+  
Sbjct: 389 HALIRRSQRLSSNITTISEIEIPFDEKWEFPRNRLCIGKMLGEGAFGQVLEAEAVGIMKD 448

Query: 147 NHQP--VLVAVKTAKLESMTKEQIKEIMREARLMRNL-DHINVVKFFGVAAGTEPLYVIM 203
             +     VAVK  K ++ T+ ++ +++ E  +MR +  HIN++   G      PL VI+
Sbjct: 449 GSKTSNTTVAVKMLKSDA-TERELSDLISEMIMMRQIGKHINIINLIGCVTQDGPLLVIV 507

Query: 204 ELADGGALDSALGKLH-----------------FPMIKKYELIYQAANGLAYIHEKNLMH 246
           E A  G L   L                               YQ + G+ ++  K  +H
Sbjct: 508 EYAPQGNLREFLRCRRPQNMDYENASLLPQVELLSNKDLVSFAYQISRGMEFLSSKKCVH 567

Query: 247 RDVAARNCLYGGGQVL 262
           RD+AARN L G   V+
Sbjct: 568 RDLAARNVLVGENNVM 583


>UniRef50_B3RWF6 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax
           adhaerens RepID=B3RWF6_TRIAD
          Length = 259

 Score =  212 bits (541), Expect = 9e-54,   Method: Composition-based stats.
 Identities = 49/160 (30%), Positives = 82/160 (51%), Gaps = 19/160 (11%)

Query: 111 RQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKE 170
           +  +E+   D+++ K+LG G FG V+ G            + VAVK  K +SM++E   +
Sbjct: 1   KDIFEINRNDLQIGKQLGRGQFGVVYFGTYRN-------SIEVAVKMLKSDSMSEE---D 50

Query: 171 IMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---------HFP 221
            +REA++M  L H N+V+ +G+ +  +PL++I E    G L   L +             
Sbjct: 51  FLREAKVMHKLKHENLVQLYGICSIGKPLFIISEFMSRGCLLDYLREHFSSTTALSSQQT 110

Query: 222 MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQV 261
           +     +  Q  + + Y+ E N +HRD+AARNCL GG  +
Sbjct: 111 VEVLLNMALQICSAMLYLEENNFIHRDLAARNCLIGGTNI 150


>UniRef50_B2WR85 Fibroblast growth factor receptor B n=4 Tax=Nematostella vectensis
           RepID=B2WR85_NEMVE
          Length = 894

 Score =  212 bits (540), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 51/215 (23%), Positives = 94/215 (43%), Gaps = 21/215 (9%)

Query: 65  ESDHKVYVDKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELT 124
           + +H +      + + + L+    S +    +    V  +       ++WEL    + L 
Sbjct: 442 QRNHSMRTSTSSYGSTVPLLARERSMRSRLGSNLSQVSEIELP--LDEEWELDRSQISLL 499

Query: 125 KKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNL-DH 183
             LGEGAFG V K   + + +  ++   VAVK  K ++ T+ ++ +++ E  +M+ +  H
Sbjct: 500 GILGEGAFGRVVKADAIGLPNMPYR-CNVAVKMLKEDA-TEHELADLVSEMEVMKTIGQH 557

Query: 184 INVVKFFGVAAGTEPLYVIMELADGGALDSALG----------------KLHFPMIKKYE 227
           +N++   G      PL+V++E A  G L   L                 +    ++    
Sbjct: 558 VNIINLIGACTQKGPLFVVVEYASQGNLRQFLRARRPIPEYANPLTEPPREKLKLVDLVS 617

Query: 228 LIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             YQ A G+ Y+  K  +HRD+AARN L     V+
Sbjct: 618 FSYQVARGMEYLESKKCIHRDLAARNVLVSDNHVI 652


>UniRef50_Q170Z1 Tyrosine-protein kinase receptor (Fragment) n=1 Tax=Aedes aegypti
            RepID=Q170Z1_AEDAE
          Length = 2073

 Score =  211 bits (539), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 48/154 (31%), Positives = 77/154 (50%), Gaps = 13/154 (8%)

Query: 115  ELYHEDVELTKK--LGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
            ++  E + +T    LG GAFGEV++G +  +         VA+KT +  + T+++  E +
Sbjct: 1804 QIRREQISMTSSPFLGSGAFGEVYEGIVKGV--GGEAETRVAIKTLRKGA-TEQEKAEFL 1860

Query: 173  REARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIK 224
            +EA LM N  H +++K  GV    + LY++MEL  GG L S L              ++ 
Sbjct: 1861 QEAHLMSNFKHKHILKLIGVCLDLDSLYIVMELMQGGDLLSYLRSNRPTPGNPSMLTLLD 1920

Query: 225  KYELIYQAANGLAYIHEKNLMHRDVAARNCLYGG 258
               +    A G  Y+ E + +HRD+A RNCL   
Sbjct: 1921 LISMCVDVATGCRYLEEMHFVHRDLACRNCLVSS 1954


>UniRef50_B0XJJ2 Testis-specific serine/threonine-protein kinase 6 n=1 Tax=Culex
           quinquefasciatus RepID=B0XJJ2_CULQU
          Length = 590

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 53/162 (32%), Positives = 78/162 (48%), Gaps = 15/162 (9%)

Query: 114 WELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMR 173
           WEL  + + L K LGEGAFG V +GK     +  +  + VAVK  +    T E +K+++ 
Sbjct: 311 WELPRQRIVLGKLLGEGAFGRVVQGKASGFAEGAN-SIPVAVKMLRENH-TDEDVKDLVC 368

Query: 174 EARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALG------------KLHF 220
           E  +M+ +  H NV+   G  +   PLYVI+E A  G L + L             K   
Sbjct: 369 ELEIMKMIGKHPNVISLVGCCSNKGPLYVIIEYATHGNLKNFLRGFRFEGSFDKLDKQAI 428

Query: 221 PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            + +      Q A G+ Y+     +HRD+AARN L   G V+
Sbjct: 429 SVQRLVTFALQIATGMEYLSSIKCIHRDLAARNILVSEGYVM 470


>UniRef50_UPI0001792C07 PREDICTED: similar to tyrosine-protein kinase n=1 Tax=Acyrthosiphon
            pisum RepID=UPI0001792C07
          Length = 1518

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 48/147 (32%), Positives = 85/147 (57%), Gaps = 6/147 (4%)

Query: 116  LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
            +  E + LTK+LG GAFGEV++GK+  ++    +   VA+K+ K  + +  +++E ++EA
Sbjct: 1146 IKREQITLTKRLGSGAFGEVFEGKIKDVVRGECE-TRVAIKSLKEGA-SHCEVEEFLKEA 1203

Query: 176  RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH----FPMIKKYELIYQ 231
            +LM N +H ++++  GV    +P ++IMEL + G L S L K        +    ++   
Sbjct: 1204 KLMNNFNHKHILQLIGVCLDNDPNFIIMELMEEGDLLSYLRKNRQTNVLNLSDYGQMCID 1263

Query: 232  AANGLAYIHEKNLMHRDVAARNCLYGG 258
             A G +Y+ + + +HRD+A RNCL   
Sbjct: 1264 VAEGCSYLEQMHFIHRDLACRNCLVSS 1290


>UniRef50_B0XJ86 Fibroblast growth factor receptor 1 n=1 Tax=Culex quinquefasciatus
           RepID=B0XJ86_CULQU
          Length = 579

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 46/161 (28%), Positives = 72/161 (44%), Gaps = 15/161 (9%)

Query: 115 ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
           E   + + L K LGEGAFG V + +   ++        VAVK  K +  T+  I +++ E
Sbjct: 292 EFPRDQLILGKVLGEGAFGRVVQAEAKGLIAGTD-STAVAVKMLKKDH-TEGDINDLLSE 349

Query: 175 ARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHF------------P 221
             +M+ +  H N++ F G      P  +I+E A  G L   L +                
Sbjct: 350 MDIMKMVGRHPNIINFLGFCYKDGPPLIIVEYAAHGNLKDFLRRHQLSSDSTDNSKPILT 409

Query: 222 MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           +       YQ ANG+ ++     +HRD+AARN L   G V+
Sbjct: 410 LNDLVSFAYQVANGMNHLTSMKCVHRDLAARNILVSEGHVM 450


>UniRef50_UPI000186EE87 tyrosine kinase receptor, putative n=4 Tax=Neoptera
           RepID=UPI000186EE87
          Length = 630

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 55/168 (32%), Positives = 82/168 (48%), Gaps = 17/168 (10%)

Query: 110 ERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIK 169
              KWE     +++   LGEG FG+VW+ + L I       V VAVKT K ES  +++ K
Sbjct: 316 PGDKWEFPRHHLKVFNILGEGCFGQVWRCEALNIDGREGTTV-VAVKTLK-ESAGEKERK 373

Query: 170 EIMREARLMRNLD-HINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------- 219
           ++++E  +M++L+ H N+V+  G     +PL+VIME    G L S L             
Sbjct: 374 DLLQELEVMKSLEPHPNIVRLLGCCTKKDPLFVIMEFVSLGKLQSYLRNSRAERCYGNMH 433

Query: 220 -----FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                          YQ A G+ ++  K ++HRD+AARN L    QV 
Sbjct: 434 GESKTLTSRDLTSFAYQCARGMEFLSNKGIIHRDLAARNILVNNDQVC 481


>UniRef50_Q16832 Discoidin domain-containing receptor 2 n=50 Tax=Chordata
           RepID=DDR2_HUMAN
          Length = 855

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 52/214 (24%), Positives = 88/214 (41%), Gaps = 30/214 (14%)

Query: 78  PTIIELVNHY----VSTKESFSTKDGTVKAVLKQAVERQK----WELYHEDVELTKKLGE 129
           P+  E V HY    +   +  +  +      +   +   K     E   + +   +KLGE
Sbjct: 512 PSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGE 571

Query: 130 GAFGEVWKGKLLKILDAN----------HQPVLVAVKTAKLESMTKEQIKEIMREARLMR 179
           G FGEV   ++  +              +QPVLVAVK  + ++  K    + ++E ++M 
Sbjct: 572 GQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA-NKNARNDFLKEIKIMS 630

Query: 180 NLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMI-----------KKYEL 228
            L   N++    V    +PL +I E  + G L+  L +   P                 +
Sbjct: 631 RLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFM 690

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             Q A+G+ Y+   N +HRD+A RNCL G    +
Sbjct: 691 ATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI 724


>UniRef50_Q52V39 Tyrosine-protein kinase receptor n=3 Tax=Branchiostoma floridae
           RepID=Q52V39_BRAFL
          Length = 797

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 53/162 (32%), Positives = 85/162 (52%), Gaps = 17/162 (10%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +  + +    +LGEGAFG V+ GK  K+   +    LVAVKT K  S+ ++  K+  REA
Sbjct: 505 IQRDTIHFVGELGEGAFGRVYLGKCEKL-KPDEDASLVAVKTLKEMSV-EDARKDFDREA 562

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL---------------HF 220
            L+ N+ H N+VKF+GV    EP  +I E  + G L++ L                    
Sbjct: 563 ELLTNMQHENIVKFYGVCTEGEPWLMIFEYMENGDLNNYLRSHGPDAAFLIKNPATHKEL 622

Query: 221 PMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
            +++  ++  Q A+G+ Y+  ++ +HRD+A RNCL G   V+
Sbjct: 623 SIVELLQISVQVASGVEYMASQHFVHRDLATRNCLVGDKLVV 664


>UniRef50_B4N8K5 GK12078 n=18 Tax=Metazoa RepID=B4N8K5_DROWI
          Length = 1984

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 47/203 (23%), Positives = 78/203 (38%), Gaps = 27/203 (13%)

Query: 83   LVNHYVSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLK 142
            L      T                       WE+  + +     LG+G+FG V++G L  
Sbjct: 1154 LYKKKKMTPRDLYINTEVNPFYASHQYIPDDWEVARDCILQLGPLGQGSFGMVYEGILKG 1213

Query: 143  ILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVI 202
             +         A+KT    +  +E++   + EA +M+  D  +VV   GV +  +P  V+
Sbjct: 1214 HM---GVDTPCAIKTVNENATDRERV-NFLSEASVMKEFDTFHVVHLLGVCSHGQPALVV 1269

Query: 203  MELADGGALDSALGKLH-----------------------FPMIKKYELIYQAANGLAYI 239
            MEL   G L S L                               + Y++  + A+G+AY+
Sbjct: 1270 MELMKKGDLKSYLRAHRPEERNEEMLAYLQRIGVTGNASPPTYGRFYQMAIEIADGMAYL 1329

Query: 240  HEKNLMHRDVAARNCLYGGGQVL 262
              K  +HRD+AARNC+      +
Sbjct: 1330 SAKKFVHRDLAARNCMVSDDLTV 1352


>UniRef50_P21709 Ephrin type-A receptor 1 n=21 Tax=Mammalia RepID=EPHA1_HUMAN
          Length = 976

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 46/170 (27%), Positives = 74/170 (43%), Gaps = 6/170 (3%)

Query: 95  STKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVA 154
              D        Q       EL    + +   +GEG FGEV++G L      +     VA
Sbjct: 598 PYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRL---PSQDCKTVA 654

Query: 155 VKTAKLESMTKEQIKEIMREARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSA 214
           +KT K ++    Q    +REA +M    H +++   GV    +P+ +I E  + GALD+ 
Sbjct: 655 IKTLK-DTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAF 713

Query: 215 LGKL--HFPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
           L +        +   ++   A+G+ Y+   N +HRD+AARN L       
Sbjct: 714 LREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCC 763


>UniRef50_UPI000180B27C PREDICTED: similar to proto-oncogene c-ros, partial n=1 Tax=Ciona
           intestinalis RepID=UPI000180B27C
          Length = 1050

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 46/151 (30%), Positives = 72/151 (47%), Gaps = 10/151 (6%)

Query: 117 YHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREAR 176
             + ++L   +G GAFGEV+KG    I     +   VAVKT K  + ++ +  E + EA 
Sbjct: 598 PRDQLKLGMLIGSGAFGEVYKGTAAGISGGEGEA-SVAVKTLKDGA-SENEKMEFLMEAY 655

Query: 177 LMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALG--------KLHFPMIKKYEL 228
            M   DH N++   GV    EP ++I+EL +GG L   L               +   ++
Sbjct: 656 FMSLFDHRNIISLLGVCLDNEPQFLILELMEGGDLLKYLRHARPTQMMSSKLSFLDLIDI 715

Query: 229 IYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
               + G  Y+  ++ +HRD+AARNCL    
Sbjct: 716 CLDLSAGCKYLESQHFIHRDLAARNCLVSSK 746


>UniRef50_B4DP99 cDNA FLJ51496, highly similar to Tyrosine-protein kinase CSK (EC
           2.7.10.2) n=6 Tax=Euteleostomi RepID=B4DP99_HUMAN
          Length = 399

 Score =  211 bits (537), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 48/198 (24%), Positives = 84/198 (42%), Gaps = 21/198 (10%)

Query: 73  DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQAVERQK-----WELYHEDVELTKKL 127
           +++ F  +++LV HY S  +   T+    K +      + +     W L  ++++L + +
Sbjct: 91  EEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTI 150

Query: 128 GEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVV 187
           G+G FG+V  G              VAVK  K ++  +      + EA +M  L H N+V
Sbjct: 151 GKGEFGDVMLGDYRGN--------KVAVKCIKNDATAQA----FLAEASVMTQLRHSNLV 198

Query: 188 KFFGVAAGTEP-LYVIMELADGGALDSALGKLHFPM---IKKYELIYQAANGLAYIHEKN 243
           +  GV    +  LY++ E    G+L   L      +       +        + Y+   N
Sbjct: 199 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 258

Query: 244 LMHRDVAARNCLYGGGQV 261
            +HRD+AARN L     V
Sbjct: 259 FVHRDLAARNVLVSEDNV 276


>UniRef50_A9VBG8 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VBG8_MONBE
          Length = 1803

 Score =  211 bits (537), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 50/175 (28%), Positives = 81/175 (46%), Gaps = 15/175 (8%)

Query: 100  TVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAK 159
                   +  E  ++E   E V L ++LG GAFG V+ G +  I + + + V VAVK   
Sbjct: 1264 KAAEDEWRVPEADEFEYPRERVRLGRQLGSGAFGMVFAGHVTDIREISGE-VAVAVKLCS 1322

Query: 160  LESMTKEQIKEIMREARLMRNLD---HINVVKFFGVAAGTEPLYVIMELADGGALDSALG 216
             ++   ++  + + EA LM+      H NV++  GV    EP+ +I+E    G L   L 
Sbjct: 1323 SKAA--KEKNDFLEEANLMKRFAKPWHPNVLRLLGVVTQEEPMMIILENMANGDLLGFLR 1380

Query: 217  KLH---------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                          M     +    A+G+A++ + N +HRD+AARNCL     V+
Sbjct: 1381 GARPPAPGQDAALTMTDLVYMAADVASGMAFLAQGNFIHRDLAARNCLVAEDMVV 1435


>UniRef50_Q7KJ08 Alk n=7 Tax=melanogaster group RepID=Q7KJ08_DROME
          Length = 1701

 Score =  211 bits (537), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 46/153 (30%), Positives = 74/153 (48%), Gaps = 10/153 (6%)

Query: 115  ELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMRE 174
            ++  + ++L   LG+GAFGEV+        D +   + VAVKT + +   +E+ ++ ++E
Sbjct: 1187 QVARDSLQLVNALGKGAFGEVYMALYR-HRDGDAVEMGVAVKTLRED-PKREKEEDFLKE 1244

Query: 175  ARLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIKKY 226
            A +M   +H N+V   GV    +P Y+++EL  GG L   L +            M    
Sbjct: 1245 AAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLL 1304

Query: 227  ELIYQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
                  A G  Y+  K  +HRD+AARNCL    
Sbjct: 1305 FCALDVAKGCRYMESKRFIHRDIAARNCLLSSK 1337


>UniRef50_A9V127 Predicted protein n=2 Tax=Fungi/Metazoa group RepID=A9V127_MONBE
          Length = 2193

 Score =  211 bits (537), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 49/180 (27%), Positives = 80/180 (44%), Gaps = 12/180 (6%)

Query: 88  VSTKESFSTKDGTVKAVLKQAVERQKWELYHEDVELTKKLGEGAFGEVWKGKLLKILDAN 147
            + + S   + G V     +   R+ WE+   D+EL + LG+GAFG V        +   
Sbjct: 763 RTAQNSHEERLGNVVLAKYKRDGRRLWEIPRHDIELGRLLGQGAFGNVHFATAR-HVVPL 821

Query: 148 HQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLD-HINVVKFFGVAAGTEPLYVIMELA 206
            +   VAVKT   ++      ++ + E R+M+  D H NVV+  G+    EP+ +++E  
Sbjct: 822 EESTKVAVKTLNRDA-DALDKEDFLEEIRVMQQFDEHPNVVRLLGICTLDEPMMLLVEYM 880

Query: 207 DGGALDSALGKLH---------FPMIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYG 257
             G +   L +               +    +   A G+AYI  K  +HRD+AARN L  
Sbjct: 881 PDGNMRDFLREARPKTPGAAASVTSTQMLGFLKDVAAGMAYIAGKRFVHRDLAARNVLLH 940


>UniRef50_B0XF28 Fibroblast growth factor receptor 2 n=1 Tax=Culex quinquefasciatus
           RepID=B0XF28_CULQU
          Length = 511

 Score =  210 bits (536), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 51/157 (32%), Positives = 74/157 (47%), Gaps = 9/157 (5%)

Query: 113 KWELYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIM 172
           +WE   E + L  +LG GAFG V       +L        VAVK  K E  T + +K+++
Sbjct: 211 EWEFPREKLTLANQLGAGAFGNVVLAVAEGLLF-EGVDTPVAVKMLKDEH-TDDDVKDLV 268

Query: 173 REARLMRNL-DHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH------FPMIKK 225
            E  +M+ + +H NVV   G      PL+VI+E A  G L S L              + 
Sbjct: 269 CEMEIMKKIGNHPNVVSLLGSCTRNGPLFVIVEYAVHGNLKSFLQDHRSESTTTLTTNQL 328

Query: 226 YELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
                Q A+G+ ++    L+HRD+AARN L   G V+
Sbjct: 329 VSFASQIASGMQHLSSMKLIHRDLAARNILVSEGFVM 365


>UniRef50_D2H0P6 Tyrosine-protein kinase receptor (Fragment) n=5 Tax=Coelomata
           RepID=D2H0P6_AILME
          Length = 295

 Score =  210 bits (536), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 48/161 (29%), Positives = 78/161 (48%), Gaps = 17/161 (10%)

Query: 116 LYHEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREA 175
           +   ++ L ++LGEGAFG+V+  +   +       +LVAVKT K    +    K+  REA
Sbjct: 6   IKRHNIVLKRELGEGAFGKVFLAECYNLC-PEQDKILVAVKTLKD--ASDNARKDFHREA 62

Query: 176 RLMRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKL--------------HFP 221
            L+ NL H ++VKF+GV    +PL ++ E    G L+  L                    
Sbjct: 63  ELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELT 122

Query: 222 MIKKYELIYQAANGLAYIHEKNLMHRDVAARNCLYGGGQVL 262
             +   +  Q A G+ Y+  ++ +HRD+A RNCL G   ++
Sbjct: 123 QSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV 163


>UniRef50_Q28WN9 GA20930 n=6 Tax=Drosophila RepID=Q28WN9_DROPS
          Length = 1705

 Score =  210 bits (536), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 10/150 (6%)

Query: 118  HEDVELTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARL 177
             + ++L   LG+GAFGEV+        D +   + VAVKT + +   +E+ ++ ++EA +
Sbjct: 1194 RDSLQLVNALGKGAFGEVYMALYR-HRDGDAVEMGVAVKTLRED-PKREKEEDFLKEAAI 1251

Query: 178  MRNLDHINVVKFFGVAAGTEPLYVIMELADGGALDSALGKLH--------FPMIKKYELI 229
            M   +H N+V   GV    +P Y+++EL  GG L   L +            M       
Sbjct: 1252 MAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCA 1311

Query: 230  YQAANGLAYIHEKNLMHRDVAARNCLYGGG 259
               A G  Y+  K  +HRD+AARNCL    
Sbjct: 1312 LDVAKGCRYMESKRFIHRDIAARNCLLSSK 1341


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.312    0.183    0.648 

Lambda     K      H
   0.267   0.0562    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,055,520,874
Number of Sequences: 3077464
Number of extensions: 107198257
Number of successful extensions: 413366
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 27963
Number of HSP's successfully gapped in prelim test: 23029
Number of HSP's that attempted gapping in prelim test: 287617
Number of HSP's gapped (non-prelim): 58675
length of query: 262
length of database: 1,040,396,356
effective HSP length: 126
effective length of query: 136
effective length of database: 652,635,892
effective search space: 88758481312
effective search space used: 88758481312
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.9 bits)
S2: 93 (40.0 bits)
