Phyre 2 Results for O61768

Phyre Home | Retrieve Phyre Job Id

Email | l.a.kelley@imperial.ac.uk
Description | O61768
Date | Sat Apr 13 13:04:39 BST 2013
Unique Job ID | cba8a7bd53f021fa

Summary |

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å): | X:63.065 Y:66.029 Z:49.470
| Close Jmol

Model (left) based on template c2fo0A_
Top template information
PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
Confidence and coverage
Confidence: | 100.0% | Coverage: | 94%
247 residues ( 94% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | T | D | K | D | L | L | H | Q | K | Y | Y | H | G | L | L | P | R | E | D | I | Q | E | M | L | N | K | P | G | Q | F | L | L | R | T | S | E | P | V | K | G | E | K | R | Q | F | V | L | S | V | V | G | E | K | K | T | S | A | N | H
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | F | V | V | R | E | S | D | H | K | V | Y | V | D | K | I | G | F | P | T | I | I | E | L | V | N | H | Y | V | S | T | K | E | S | F | S | T | K | D | G | T | V | K | A | V | L | K | Q | A | V | E | R | Q | K | W | E | L | Y | H | E | D
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  | ? |  | ? |  |  | ? | ? | ? | ? |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  | ? |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | V | E | L | T | K | K | L | G | E | G | A | F | G | E | V | W | K | G | K | L | L | K | I | L | D | A | N | H | Q | P | V | L | V | A | V | K | T | A | K | L | E | S | M | T | K | E | Q | I | K | E | I | M | R | E | A | R | L | M | R | N
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | L | D | H | I | N | V | V | K | F | F | G | V | A | A | G | T | E | P | L | Y | V | I | M | E | L | A | D | G | G | A | L | D | S | A | L | G | K | L | H | F | P | M | I | K | K | Y | E | L | I | Y | Q | A | A | N | G | L | A | Y | I | H
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | .
Sequence |  | E | K | N | L | M | H | R | D | V | A | A | R | N | C | L | Y | G | G | G | Q | V | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)
? | Disordered ( 19%)
| Alpha helix ( 25%)
| Beta strand ( 30%)

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c2fo0A_ |

### PDB 2fo0 chain A

Region: 4 - 262
Aligned: 247
Modelled: 259
Confidence: 100.0%
Identity: 30%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2
2 |
| c1oplA_ |

### PDB 1opl chain A

Region: 4 - 262
Aligned: 247
Modelled: 259
Confidence: 100.0%
Identity: 30%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase

Phyre2
3 |
| c1k9aB_ |

### PDB 1k9a chain B

Region: 3 - 262
Aligned: 243
Modelled: 256
Confidence: 100.0%
Identity: 28%
PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution

Phyre2
4 |
| c1y57A_ |

### PDB 1y57 chain A

Region: 3 - 262
Aligned: 249
Modelled: 260
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor

Phyre2
5 |
| c2h8hA_ |

### PDB 2h8h chain A

Region: 4 - 262
Aligned: 245
Modelled: 256
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor

Phyre2
6 |
| c2c0iA_ |

### PDB 2c0i chain A

Region: 4 - 262
Aligned: 245
Modelled: 257
Confidence: 100.0%
Identity: 34%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983

Phyre2
7 |
| c4fl2A_ |

### PDB 4fl2 chain A

Region: 2 - 262
Aligned: 252
Modelled: 261
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch

Phyre2
8 |
| c2ozoA_ |

### PDB 2ozo chain A

Region: 7 - 262
Aligned: 246
Modelled: 256
Confidence: 100.0%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2
9 |
| c3cblA_ |

### PDB 3cbl chain A

Region: 3 - 262
Aligned: 224
Modelled: 237
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide

Phyre2
10 |
| c4im2A_ |

### PDB 4im2 chain A

Region: 115 - 262
Aligned: 137
Modelled: 148
Confidence: 100.0%
Identity: 26%
PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:serine/threonine-protein kinase tbk1;
PDBTitle: structure of tank-binding kinase 1

Phyre2
11 |
| c3qa8H_ |

### PDB 3qa8 chain H

Region: 122 - 260
Aligned: 132
Modelled: 139
Confidence: 100.0%
Identity: 30%
PDB header:immune system, signaling protein
Chain: H: PDB Molecule:mgc80376 protein;
PDBTitle: crystal structure of inhibitor of kappa b kinase beta

Phyre2
12 |
| c3qa8A_ |

### PDB 3qa8 chain A

Region: 122 - 260
Aligned: 132
Modelled: 139
Confidence: 100.0%
Identity: 30%
PDB header:immune system, signaling protein
Chain: A: PDB Molecule:mgc80376 protein;
PDBTitle: crystal structure of inhibitor of kappa b kinase beta

Phyre2
13 |
| c3c4wB_ |

### PDB 3c4w chain B

Region: 115 - 262
Aligned: 142
Modelled: 148
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: B: PDB Molecule:rhodopsin kinase;
PDBTitle: crystal structure of g protein coupled receptor kinase 1 bound to atp2 and magnesium chloride at 2.7a

Phyre2
14 |
| c2j0kB_ |

### PDB 2j0k chain B

Region: 106 - 262
Aligned: 152
Modelled: 157
Confidence: 100.0%
Identity: 32%
PDB header:transferase
Chain: B: PDB Molecule:focal adhesion kinase 1;
PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains.

Phyre2
15 |
| c1ym7C_ |

### PDB 1ym7 chain C

Region: 116 - 262
Aligned: 141
Modelled: 147
Confidence: 100.0%
Identity: 21%
PDB header:transferase
Chain: C: PDB Molecule:beta-adrenergic receptor kinase 1;
PDBTitle: g protein-coupled receptor kinase 2 (grk2)

Phyre2
16 |
| c3c4yA_ |

### PDB 3c4y chain A

Region: 114 - 262
Aligned: 143
Modelled: 149
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: A: PDB Molecule:rhodopsin kinase;
PDBTitle: crystal structure of apo form of g protein coupled receptor kinase 12 at 7.51a

Phyre2
17 |
| c2acxB_ |

### PDB 2acx chain B

Region: 112 - 262
Aligned: 145
Modelled: 151
Confidence: 100.0%
Identity: 19%
PDB header:transferase
Chain: B: PDB Molecule:g protein-coupled receptor kinase 6;
PDBTitle: crystal structure of g protein coupled receptor kinase 6 bound to2 amppnp

Phyre2
18 |
| c3nyoB_ |

### PDB 3nyo chain B

Region: 114 - 262
Aligned: 143
Modelled: 149
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: B: PDB Molecule:g protein-coupled receptor kinase 6;
PDBTitle: crystal structure of g protein-coupled receptor kinase 6 in complex2 with amp

Phyre2
19 |
| c3pfqA_ |

### PDB 3pfq chain A

Region: 103 - 262
Aligned: 154
Modelled: 160
Confidence: 100.0%
Identity: 19%
PDB header:transferase
Chain: A: PDB Molecule:protein kinase c beta type;
PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii

Phyre2
20 |
| c3tkuB_ |

### PDB 3tku chain B

Region: 116 - 262
Aligned: 141
Modelled: 147
Confidence: 100.0%
Identity: 26%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:serine/threonine-protein kinase mrck beta;
PDBTitle: mrck beta in complex with fasudil

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c2fo0A_ |
|  | 100.0 | 30 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
2 | c1oplA_ |
|  | 100.0 | 30 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
3 | c1k9aB_ |
|  | 100.0 | 28 | PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
4 | c1y57A_ |
|  | 100.0 | 29 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
5 | c2h8hA_ |
|  | 100.0 | 29 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor
6 | c2c0iA_ |
|  | 100.0 | 34 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983
7 | c4fl2A_ |
|  | 100.0 | 27 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch
8 | c2ozoA_ |
|  | 100.0 | 28 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70
9 | c3cblA_ |
|  | 100.0 | 37 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
10 | c4im2A_ |
|  | 100.0 | 26 | PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:serine/threonine-protein kinase tbk1; PDBTitle: structure of tank-binding kinase 1
11 | c3qa8H_ |
|  | 100.0 | 30 | PDB header:immune system, signaling protein Chain: H: PDB Molecule:mgc80376 protein; PDBTitle: crystal structure of inhibitor of kappa b kinase beta
12 | c3qa8A_ |
|  | 100.0 | 30 | PDB header:immune system, signaling protein Chain: A: PDB Molecule:mgc80376 protein; PDBTitle: crystal structure of inhibitor of kappa b kinase beta
13 | c3c4wB_ |
|  | 100.0 | 20 | PDB header:transferase Chain: B: PDB Molecule:rhodopsin kinase; PDBTitle: crystal structure of g protein coupled receptor kinase 1 bound to atp2 and magnesium chloride at 2.7a
14 | c2j0kB_ |
|  | 100.0 | 32 | PDB header:transferase Chain: B: PDB Molecule:focal adhesion kinase 1; PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains.
15 | c1ym7C_ |
|  | 100.0 | 21 | PDB header:transferase Chain: C: PDB Molecule:beta-adrenergic receptor kinase 1; PDBTitle: g protein-coupled receptor kinase 2 (grk2)
16 | c3c4yA_ |
|  | 100.0 | 20 | PDB header:transferase Chain: A: PDB Molecule:rhodopsin kinase; PDBTitle: crystal structure of apo form of g protein coupled receptor kinase 12 at 7.51a
17 | c2acxB_ |
|  | 100.0 | 19 | PDB header:transferase Chain: B: PDB Molecule:g protein-coupled receptor kinase 6; PDBTitle: crystal structure of g protein coupled receptor kinase 6 bound to2 amppnp
18 | c3nyoB_ |
|  | 100.0 | 20 | PDB header:transferase Chain: B: PDB Molecule:g protein-coupled receptor kinase 6; PDBTitle: crystal structure of g protein-coupled receptor kinase 6 in complex2 with amp
19 | c3pfqA_ |
|  | 100.0 | 19 | PDB header:transferase Chain: A: PDB Molecule:protein kinase c beta type; PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii
20 | c3tkuB_ |
|  | 100.0 | 26 | PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:serine/threonine-protein kinase mrck beta; PDBTitle: mrck beta in complex with fasudil
21 | c4eutA_ |
| not modelled | 100.0 | 26 | PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:serine/threonine-protein kinase tbk1; PDBTitle: structure of bx-795 complexed with unphosphorylated human tbk1 kinase-2 uld domain
22 | c2pziA_ |
| not modelled | 100.0 | 22 | PDB header:transferase Chain: A: PDB Molecule:probable serine/threonine-protein kinase pkng; PDBTitle: crystal structure of protein kinase pkng from mycobacterium2 tuberculosis in complex with tetrahydrobenzothiophene ax20017
23 | c1koaA_ |
| not modelled | 100.0 | 22 | PDB header:kinase Chain: A: PDB Molecule:twitchin; PDBTitle: twitchin kinase fragment (c.elegans), autoregulated protein2 kinase and immunoglobulin domains
24 | c2vwiC_ |
| not modelled | 100.0 | 25 | PDB header:transferase Chain: C: PDB Molecule:serine/threonine-protein kinase osr1; PDBTitle: structure of the osr1 kinase, a hypertension drug target
25 | c3soaA_ |
| not modelled | 100.0 | 21 | PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase type ii subunit PDBTitle: full-length human camkii
26 | c2c30A_ |
| not modelled | 100.0 | 26 | PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase pak 6; PDBTitle: crystal structure of the human p21-activated kinase 6
27 | c3g0eA_ |
| not modelled | 100.0 | 31 | PDB header:transferase Chain: A: PDB Molecule:mast/stem cell growth factor receptor; PDBTitle: kit kinase domain in complex with sunitinib
28 | c3ckxA_ |
| not modelled | 100.0 | 27 | PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase 24; PDBTitle: crystal structure of sterile 20-like kinase 3 (mst3, stk24)2 in complex with staurosporine
29 | c4dn5A_ |
| not modelled | 100.0 | 23 | PDB header:transferase Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 14; PDBTitle: crystal structure of nf-kb-inducing kinase (nik)
30 | c3d9vA_ |
| not modelled | 100.0 | 26 | PDB header:transferase Chain: A: PDB Molecule:rho-associated protein kinase 1; PDBTitle: crystal structure of rock i bound to h-1152p a di-2 methylated variant of fasudil
31 | c3fbvL_ |
| not modelled | 100.0 | 27 | PDB header:transferase, hydrolase Chain: L: PDB Molecule:serine/threonine-protein kinase/endoribonuclease ire1; PDBTitle: crystal structure of the oligomer formed by the kinase-ribonuclease2 domain of ire1
32 | c3q5iA_ |
| not modelled | 100.0 | 25 | PDB header:transferase Chain: A: PDB Molecule:protein kinase; PDBTitle: crystal structure of pbanka_031420
33 | c2vuwA_ |
| not modelled | 100.0 | 23 | PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase haspin; PDBTitle: structure of human haspin kinase domain
34 | c4fijA_ |
| not modelled | 100.0 | 24 | PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase pak 4; PDBTitle: catalytic domain of human pak4
35 | c2kulA_ |
| not modelled | 100.0 | 20 | PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase vrk1; PDBTitle: solution structure of human vaccinia related kinase 1(vrk1)
36 | c3vw6B_ |
| not modelled | 100.0 | 26 | PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:mitogen-activated protein kinase kinase kinase 5; PDBTitle: crystal structure of human apoptosis signal-regulating kinase 1 (ask1)2 with imidazopyridine inhibitor
37 | c2ivsA_ |
| not modelled | 100.0 | 32 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase receptor PDBTitle: crystal structure of non-phosphorylated ret tyrosine kinase2 domain
38 | c3p23B_ |
| not modelled | 100.0 | 28 | PDB header:hydrolase, transferase Chain: B: PDB Molecule:serine/threonine-protein kinase/endoribonuclease ire1; PDBTitle: crystal structure of the human kinase and rnase domains in complex2 with adp
39 | d1qcfa3 |
| not modelled | 100.0 | 36 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
40 | c3e7eA_ |
| not modelled | 100.0 | 18 | PDB header:transferase Chain: A: PDB Molecule:mitotic checkpoint serine/threonine-protein kinase bub1; PDBTitle: structure and substrate recruitment of the human spindle checkpoint2 kinase bub
41 | c3rp9A_ |
| not modelled | 100.0 | 24 | PDB header:transferase Chain: A: PDB Molecule:mitogen-activated protein kinase; PDBTitle: crystal structure of the apo mapk from toxoplasma gondii, 25.m01780 or2 tgme49_007820
42 | d2j4za1 |
| not modelled | 100.0 | 27 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
43 | d1opja_ |
| not modelled | 100.0 | 33 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
44 | c4fieB_ |
| not modelled | 100.0 | 24 | PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase pak 4; PDBTitle: full-length human pak4
45 | c2clqA_ |
| not modelled | 99.9 | 24 | PDB header:transferase Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 5; PDBTitle: structure of mitogen-activated protein kinase kinase kinase2 5
46 | d1yhwa1 |
| not modelled | 99.9 | 23 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
47 | c3dfaA_ |
| not modelled | 99.9 | 31 | PDB header:transferase Chain: A: PDB Molecule:calcium-dependent protein kinase cgd3_920; PDBTitle: crystal structure of kinase domain of calcium-dependent protein kinase2 cgd3_920 from cryptosporidium parvum
48 | c2jamB_ |
| not modelled | 99.9 | 28 | PDB header:transferase Chain: B: PDB Molecule:calcium/calmodulin-dependent protein kinase type PDBTitle: crystal structure of human calmodulin-dependent protein2 kinase i g
49 | c3zzwA_ |
| not modelled | 99.9 | 31 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase transmembrane receptor ror2; PDBTitle: crystal structure of the kinase domain of ror2
50 | c3hztA_ |
| not modelled | 99.9 | 29 | PDB header:transferase Chain: A: PDB Molecule:calcium-dependent protein kinase 3; PDBTitle: crystal structure of toxoplasma gondii cdpk3, tgme49_105860
51 | c2pvfA_ |
| not modelled | 99.9 | 34 | PDB header:transferase Chain: A: PDB Molecule:fibroblast growth factor receptor 2; PDBTitle: crystal structure of tyrosine phosphorylated activated fgf receptor 22 (fgfr2) kinase domain in complex with atp analog and substrate3 peptide
52 | c2wtkC_ |
| not modelled | 99.9 | 26 | PDB header:transferase/metal-binding protein Chain: C: PDB Molecule:serine/threonine-protein kinase 11; PDBTitle: structure of the heterotrimeric lkb1-stradalpha-mo25alpha2 complex
53 | c2a27B_ |
| not modelled | 99.9 | 25 | PDB header:transferase Chain: B: PDB Molecule:death-associated protein kinase 2; PDBTitle: human drp-1 kinase, w305s s308a d40 mutant, crystal form with 82 monomers in the asymmetric unit
54 | c2psqA_ |
| not modelled | 99.9 | 33 | PDB header:transferase Chain: A: PDB Molecule:fibroblast growth factor receptor 2; PDBTitle: crystal structure of unphosphorylated unactivated wild type2 fgf receptor 2 (fgfr2) kinase domain
55 | d2psqa1 |
| not modelled | 99.9 | 33 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
56 | d1phka_ |
| not modelled | 99.9 | 19 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
57 | d3bu3a1 |
| not modelled | 99.9 | 34 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
58 | c2y7jB_ |
| not modelled | 99.9 | 17 | PDB header:transferase Chain: B: PDB Molecule:phosphorylase b kinase gamma catalytic chain, PDBTitle: structure of human phosphorylase kinase, gamma 2
59 | c3q60A_ |
| not modelled | 99.9 | 16 | PDB header:transferase Chain: A: PDB Molecule:rop5b; PDBTitle: crystal structure of virulent allele rop5b pseudokinase domain bound2 to atp
60 | c3kvwA_ |
| not modelled | 99.9 | 23 | PDB header:transferase Chain: A: PDB Molecule:dual specificity tyrosine-phosphorylation-regulated kinase PDBTitle: crystal structure of dual-specificity tyrosine phosphorylation2 regulated kinase 2 (dyrk2) in complex with an indirubin ligand
61 | c3otvC_ |
| not modelled | 99.9 | 11 | PDB header:transferase Chain: C: PDB Molecule:probable conserved transmembrane protein; PDBTitle: crystal structure of the intracellular domain of rv3910 from2 mycobacterium tuberculosis
62 | d1lufa_ |
| not modelled | 99.9 | 33 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
63 | c1lufA_ |
| not modelled | 99.9 | 33 | PDB header:transferase Chain: A: PDB Molecule:muscle-specific tyrosine kinase receptor musk; PDBTitle: crystal structure of the musk tyrosine kinase: insights2 into receptor autoregulation
64 | d1qpca_ |
| not modelled | 99.9 | 33 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
65 | c2j51A_ |
| not modelled | 99.9 | 28 | PDB header:transferase Chain: A: PDB Molecule:ste20-like serine/threonine-protein kinase; PDBTitle: crystal structure of human ste20-like kinase bound to 5-2 amino-3-((4-(aminosulfonyl)phenyl)amino)-n-(2,6-3 difluorophenyl)-1h-1,2,4-triazole-1-carbothioamide
66 | d2jfla1 |
| not modelled | 99.9 | 27 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
67 | c3dpkA_ |
| not modelled | 99.9 | 31 | PDB header:transferase Chain: A: PDB Molecule:macrophage colony-stimulating factor 1 receptor; PDBTitle: cfms tyrosine kinase in complex with a pyridopyrimidinone2 inhibitor
68 | c3lxkA_ |
| not modelled | 99.9 | 27 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase jak3; PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6
69 | c2bmcD_ |
| not modelled | 99.9 | 28 | PDB header:transferase Chain: D: PDB Molecule:serine threonine-protein kinase 6; PDBTitle: aurora-2 t287d t288d complexed with pha-680632
70 | c4aojA_ |
| not modelled | 99.9 | 33 | PDB header:transferase Chain: A: PDB Molecule:high affinity nerve growth factor receptor; PDBTitle: human trka in complex with the inhibitor az-23
71 | c2bujA_ |
| not modelled | 99.9 | 23 | PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase 16; PDBTitle: crystal structure of the human serine-threonine kinase 162 in complex with staurosporine
72 | d1jksa_ |
| not modelled | 99.9 | 25 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
73 | c3op5B_ |
| not modelled | 99.9 | 23 | PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase vrk1; PDBTitle: human vaccinia-related kinase 1
74 | d1uwha_ |
| not modelled | 99.9 | 29 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
75 | c2qg5D_ |
| not modelled | 99.9 | 23 | PDB header:transferase Chain: D: PDB Molecule:calcium/calmodulin-dependent protein kinase; PDBTitle: cryptosporidium parvum calcium dependent protein kinase cgd7_1840
76 | c4ebwA_ |
| not modelled | 99.9 | 35 | PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:focal adhesion kinase 1; PDBTitle: structure of focal adhesion kinase catalytic domain in complex with2 novel allosteric inhibitor
77 | c3igoA_ |
| not modelled | 99.9 | 33 | PDB header:transferase Chain: A: PDB Molecule:calmodulin-domain protein kinase 1; PDBTitle: crystal structure of cryptosporidium parvum cdpk1, cgd3_920
78 | c1mruB_ |
| not modelled | 99.9 | 26 | PDB header:transferase Chain: B: PDB Molecule:probable serine/threonine-protein kinase pknb; PDBTitle: intracellular ser/thr protein kinase domain of2 mycobacterium tuberculosis pknb.
79 | c3d4qA_ |
| not modelled | 99.9 | 28 | PDB header:transferase Chain: A: PDB Molecule:b-raf proto-oncogene serine/threonine-protein kinase; PDBTitle: pyrazole-based inhibitors of b-raf kinase
80 | c2jiiA_ |
| not modelled | 99.9 | 13 | PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase vrk3 molecule: vaccinia PDBTitle: structure of vaccinia related kinase 3
81 | c3p1aA_ |
| not modelled | 99.9 | 17 | PDB header:transferase Chain: A: PDB Molecule:membrane-associated tyrosine- and threonine-specific cdc2- PDBTitle: structure of human membrane-associated tyrosine- and threonine-2 specific cdc2-inhibitory kinase myt1 (pkmyt1)
82 | c3lxnA_ |
| not modelled | 99.9 | 25 | PDB header:transferase Chain: A: PDB Molecule:non-receptor tyrosine-protein kinase tyk2; PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6
83 | c2ya9A_ |
| not modelled | 99.9 | 25 | PDB header:transferase Chain: A: PDB Molecule:death-associated protein kinase 2; PDBTitle: crystal structure of the autoinhibited form of mouse dapk2
84 | d1o6ya_ |
| not modelled | 99.9 | 26 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
85 | c2zv2A_ |
| not modelled | 99.9 | 23 | PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase kinase 2; PDBTitle: crystal structure of human calcium/calmodulin-dependent protein kinase2 kinase 2, beta, camkk2 kinase domain in complex with sto-609
86 | c2wtkB_ |
| not modelled | 99.9 | 19 | PDB header:transferase/metal-binding protein Chain: B: PDB Molecule:ste20-related kinase adapter protein alpha; PDBTitle: structure of the heterotrimeric lkb1-stradalpha-mo25alpha2 complex
87 | d1k2pa_ |
| not modelled | 99.9 | 34 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
88 | d1u59a_ |
| not modelled | 99.9 | 37 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
89 | c3dzoA_ |
| not modelled | 99.9 | 13 | PDB header:transferase Chain: A: PDB Molecule:rhoptry kinase domain; PDBTitle: crystal structure of a rhoptry kinase from toxoplasma gondii
90 | c3an0A_ |
| not modelled | 99.9 | 26 | PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:dual specificity mitogen-activated protein kinase kinase 6; PDBTitle: crystal structure of non-phosphorylated map2k6 as a putative auto2 inhibition state
91 | d1uu3a_ |
| not modelled | 99.9 | 26 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
92 | c2zmcA_ |
| not modelled | 99.9 | 15 | PDB header:transferase Chain: A: PDB Molecule:dual specificity protein kinase ttk; PDBTitle: crystal structure of human mitotic checkpoint kinase mps1 catalytic2 domain apo form
93 | c1xjdA_ |
| not modelled | 99.9 | 25 | PDB header:transferase Chain: A: PDB Molecule:protein kinase c, theta type; PDBTitle: crystal structure of pkc-theta complexed with staurosporine2 at 2a resolution
94 | d1xjda_ |
| not modelled | 99.9 | 25 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
95 | c2vd5A_ |
| not modelled | 99.9 | 22 | PDB header:transferase Chain: A: PDB Molecule:dmpk protein; PDBTitle: structure of human myotonic dystrophy protein kinase in2 complex with the bisindoylmaleide inhibitor bim viii
96 | d1s9ja_ |
| not modelled | 99.9 | 29 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
97 | c3i6wB_ |
| not modelled | 99.9 | 20 | PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase chk2; PDBTitle: structure and activation mechanism of the chk2 dna-damage checkpoint2 kinase
98 | c1yvjA_ |
| not modelled | 99.9 | 25 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase jak3; PDBTitle: crystal structure of the jak3 kinase domain in complex with2 a staurosporine analogue
99 | c2h6dA_ |
| not modelled | 99.9 | 23 | PDB header:signaling protein,transferase Chain: A: PDB Molecule:5'-amp-activated protein kinase catalytic subunit PDBTitle: protein kinase domain of the human 5'-amp-activated protein2 kinase catalytic subunit alpha-2 (ampk alpha-2 chain)
100 | c2a1aB_ |
| not modelled | 99.9 | 30 | PDB header:protein synthesis/transferase Chain: B: PDB Molecule:interferon-induced, double-stranded rna-activated protein PDBTitle: pkr kinase domain-eif2alpha complex
101 | c3lijA_ |
| not modelled | 99.9 | 28 | PDB header:transferase Chain: A: PDB Molecule:calcium/calmodulin dependent protein kinase with PDBTitle: crystal structure of full length cpcdpk3 (cgd5_820) in2 complex with ca2+ and amppnp
102 | d1fvra_ |
| not modelled | 99.9 | 29 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
103 | d1mp8a_ |
| not modelled | 99.9 | 35 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
104 | c2wu6A_ |
| not modelled | 99.9 | 20 | PDB header:transferase Chain: A: PDB Molecule:dual specificity protein kinase clk3; PDBTitle: crystal structure of the human clk3 in complex with dki
105 | c2y94A_ |
| not modelled | 99.9 | 25 | PDB header:transferase Chain: A: PDB Molecule:5'-amp-activated protein kinase catalytic subunit alpha-1; PDBTitle: structure of an active form of mammalian ampk
106 | c2x4fA_ |
| not modelled | 99.9 | 19 | PDB header:transferase Chain: A: PDB Molecule:myosin light chain kinase family member 4; PDBTitle: the crystal structure of the human myosin light chain2 kinase loc340156.
107 | c3is5E_ |
| not modelled | 99.9 | 27 | PDB header:transferase Chain: E: PDB Molecule:calcium-dependent protein kinase; PDBTitle: crystal structure of cdpk kinase domain from toxoplasma gondii,2 tgme49_018720
108 | c3lltA_ |
| not modelled | 99.9 | 19 | PDB header:transferase Chain: A: PDB Molecule:serine/threonine kinase-1, pflammer; PDBTitle: crystal structure of pf14_0431, kinase domain.
109 | d1t46a_ |
| not modelled | 99.9 | 31 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
110 | c2cgvA_ |
| not modelled | 99.9 | 31 | PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase chk1; PDBTitle: identification of chemically diverse chk1 inhibitors by2 receptor-based virtual screening
111 | c2vrxB_ |
| not modelled | 99.9 | 21 | PDB header:cell cycle/transferase Chain: B: PDB Molecule:serine/threonine-protein kinase 12-a; PDBTitle: structure of aurora b kinase in complex with zm447439
112 | c3byvA_ |
| not modelled | 99.9 | 16 | PDB header:transferase Chain: A: PDB Molecule:rhoptry kinase; PDBTitle: crystal structure of toxoplasma gondii specific rhoptry2 antigen kinase domain
113 | c1tqmA_ |
| not modelled | 99.9 | 21 | PDB header:ribosome Chain: A: PDB Molecule:conserved hypothetical protein; PDBTitle: crystal structure of a. fulgidus rio2 serine protein kinase bound to2 amppnp
114 | c2r7bA_ |
| not modelled | 99.9 | 27 | PDB header:signaling protein, transferase Chain: A: PDB Molecule:phosphoinositide-dependent protein kinase 1; PDBTitle: crystal structure of the phosphoinositide-dependent kinase-2 1 (pdk-1)catalytic domain bound to a dibenzonaphthyridine3 inhibitor
115 | c3lvpD_ |
| not modelled | 99.9 | 34 | PDB header:transferase Chain: D: PDB Molecule:insulin-like growth factor 1 receptor; PDBTitle: crystal structure of bisphosphorylated igf1-r kinase domain (2p) in2 complex with a bis-azaindole inhibitor
116 | c3l9pA_ |
| not modelled | 99.9 | 32 | PDB header:transferase Chain: A: PDB Molecule:anaplastic lymphoma kinase; PDBTitle: crystal structure of the anaplastic lymphoma kinase catalytic domain
117 | c3kulB_ |
| not modelled | 99.9 | 28 | PDB header:transferase Chain: B: PDB Molecule:ephrin type-a receptor 8; PDBTitle: kinase domain of human ephrin type-a receptor 8 (epha8)
118 | c2r5tA_ |
| not modelled | 99.9 | 25 | PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase sgk1; PDBTitle: crystal structure of inactive serum and glucocorticoid-2 regulated kinase 1 in complex with amp-pnp
119 | d1fmka3 |
| not modelled | 99.9 | 32 | Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit
120 | c3cokB_ |
| not modelled | 99.9 | 21 | PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase plk4; PDBTitle: crystal structure of plk4 kinase

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