Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionA1IGU4
DateTue Jul 30 13:18:16 BST 2013
Unique Job IDfbc27482fbf21594
SequenceMADFGADEAS ... Download FASTA

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:56.994 Y:50.168 Z:51.351
Model (left) based on template c2dx1A_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
Confidence and coverage
Confidence:100.0% Coverage: 31%
209 residues ( 31% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
623 residues ( 92%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol
For other options to view your downloaded structure offline see the FAQ

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MADFGADEASSKSESPEQEDQGSEDRSLLHQRLAIRELIDTEVSYLHTLRLCASDIRSHL
Secondary structure 
SS confidence 
Disorder  ????????????????????????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  QQLPPGDLDILFSNIDDIIQVSSRFLRGLQETACREEEQAHLIGNLFLEFQEEFEQVYKV
Secondary structure 
SS confidence 
Disorder 
????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  YCANYDQALLLVKAYQKEPELQKEIQGIIEAAMPQAGPSGLSFFLVIPLQRITKYPLLLQ
Secondary structure 
SS confidence 
Disorder 
?????????
?
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  KILENTPADASAHPALQRATSALQDVNGNINEYKMRKEVALKYTKVEQLSLRERLARINT
Secondary structure 
SS confidence 
Disorder 
??
?
????
????
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  HTLSKKTTRLSQMLKQEAGLVSRTEDKEFDDLEERFQWVSLCVKELRNNVVDFMGNLEVF
Secondary structure 
SS confidence 
Disorder  ??
??????
?????????
???
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  LSFRPHERSLDIPGGPAEQYCSLARDLQLHAFLQFKQRLRSLVWQPLCSLARALAGPQNL
Secondary structure 
SS confidence 
Disorder 
??????????????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  IKKRLDKLLDFDRVEEKLLDVGSVTWEEEAARHEYQALNSLLVAELPQFNQLVMQWLGQI
Secondary structure 
SS confidence 
Disorder 
???????
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  LCTFVVLQRDLADQVLRRAESTMALLPHHHVSEPDFQKLLEHTLGQSSSQLRLFQESFEK
Secondary structure 
SS confidence 
Disorder 
????????????????
?
?????????????????
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  VLPPSTTQPLLPGSEHQMQALLTRYGPEKLYQVSSNINGTGTLDLTLLRGQIVALLQNKD
Secondary structure 
SS confidence 
Disorder  ??????????????????????????
?
??
?
????
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  TKGNNSRWLVDTGGHRGYVPAGKLQLYHPIIPSEKELRGQTGTHEDSWLPAPEPTQLSVP
Secondary structure 
SS confidence 
Disorder  ??
?
???????????????????????????????????
Disorder confidence 
 
   .........610.........620.........630.........640.........650.........660
Sequence  TVPTMSQVVAVYPFVARSTHELSLQAGQPVTILEAQDKKGNPEWSLVEANGQRGYVPSNF
Secondary structure 
SS confidence 
Disorder  ???
??
??
???????
Disorder confidence 
 
   .........670......
Sequence  LARTPSPTPWGWNLPS
Secondary structure 
SS confidence 
Disorder 
?
???????????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered ( 33%)
Alpha helix ( 57%)
Beta strand ( 6%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2dx1 chain A

3D model

Region: 18 - 229
Aligned: 209
Modelled: 212
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef

Phyre2

PDB 3ky9 chain B

3D model

Region: 29 - 229
Aligned: 196
Modelled: 201
Confidence: 100.0%
Identity: 28%
PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1

Phyre2

PDB 2vrw chain B

3D model

Region: 29 - 229
Aligned: 196
Modelled: 201
Confidence: 100.0%
Identity: 27%
PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor

Phyre2

PDB 3odo chain A

3D model

Region: 8 - 228
Aligned: 219
Modelled: 221
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef

Phyre2

PDB 1xcg chain A

3D model

Region: 10 - 229
Aligned: 218
Modelled: 220
Confidence: 100.0%
Identity: 24%
PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef

Phyre2

PDB 4gou chain A

3D model

Region: 20 - 223
Aligned: 196
Modelled: 204
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:ehrgs-rhogef;
PDBTitle: crystal structure of an rgs-rhogef from entamoeba histolytica

Phyre2

PDB 1xcg chain A domain 1

3D model

Region: 11 - 229
Aligned: 217
Modelled: 219
Confidence: 100.0%
Identity: 24%
Fold: DBL homology domain (DH-domain)
Superfamily: DBL homology domain (DH-domain)
Family: DBL homology domain (DH-domain)

Phyre2

PDB 1x86 chain A

3D model

Region: 9 - 228
Aligned: 218
Modelled: 220
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa

Phyre2

PDB 3ksy chain A

3D model

Region: 31 - 229
Aligned: 197
Modelled: 199
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)

Phyre2

PDB 3jv3 chain A

3D model

Region: 6 - 223
Aligned: 216
Modelled: 218
Confidence: 100.0%
Identity: 24%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: structure of sh3e-dh unit of murine intersectin-1l

Phyre2

PDB 1foe chain A

3D model

Region: 27 - 245
Aligned: 215
Modelled: 216
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1

Phyre2

PDB 3t06 chain E

3D model

Region: 10 - 229
Aligned: 218
Modelled: 220
Confidence: 100.0%
Identity: 24%
PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa

Phyre2

PDB 2dfk chain A

3D model

Region: 22 - 229
Aligned: 205
Modelled: 208
Confidence: 100.0%
Identity: 26%
PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex

Phyre2

PDB 1txd chain A domain 1

3D model

Region: 9 - 229
Aligned: 219
Modelled: 221
Confidence: 100.0%
Identity: 21%
Fold: DBL homology domain (DH-domain)
Superfamily: DBL homology domain (DH-domain)
Family: DBL homology domain (DH-domain)

Phyre2

PDB 3bji chain A

3D model

Region: 28 - 229
Aligned: 197
Modelled: 202
Confidence: 100.0%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1

Phyre2

PDB 2dfk chain A domain 1

3D model

Region: 23 - 218
Aligned: 193
Modelled: 196
Confidence: 100.0%
Identity: 27%
Fold: DBL homology domain (DH-domain)
Superfamily: DBL homology domain (DH-domain)
Family: DBL homology domain (DH-domain)

Phyre2

PDB 2z0q chain A

3D model

Region: 22 - 226
Aligned: 188
Modelled: 190
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)

Phyre2

PDB 1xdv chain B

3D model

Region: 31 - 238
Aligned: 206
Modelled: 208
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.

Phyre2

PDB 4gyv chain A

3D model

Region: 30 - 231
Aligned: 199
Modelled: 200
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 2;
PDBTitle: crystal strucure of the dh domain of farp2

Phyre2

PDB 1ki1 chain B

3D model

Region: 22 - 229
Aligned: 206
Modelled: 208
Confidence: 100.0%
Identity: 25%
PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42

Phyre2

PDB 2lqn chain A

3D model

Region: 479 - 669
Aligned: 183
Modelled: 183
Confidence: 99.9%
Identity: 17%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 1gri chain A

3D model

Region: 511 - 664
Aligned: 141
Modelled: 141
Confidence: 99.9%
Identity: 18%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 2eyz chain A

3D model

Region: 476 - 669
Aligned: 186
Modelled: 186
Confidence: 99.9%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 2l3s chain A

3D model

Region: 511 - 664
Aligned: 146
Modelled: 146
Confidence: 99.9%
Identity: 21%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2

PDB 1ng2 chain A

3D model

Region: 510 - 667
Aligned: 127
Modelled: 127
Confidence: 99.9%
Identity: 23%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox

Phyre2

PDB 1ov3 chain A

3D model

Region: 502 - 663
Aligned: 131
Modelled: 131
Confidence: 99.9%
Identity: 22%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex

Phyre2

PDB 4avm chain A

3D model

Region: 241 - 455
Aligned: 215
Modelled: 214
Confidence: 99.9%
Identity: 15%
PDB header:protein binding
Chain: A: PDB Molecule:bridging integrator 2;
PDBTitle: crystal structure of the n-bar domain of human bridging2 integrator 2.

Phyre2

PDB 2fic chain A

3D model

Region: 267 - 449
Aligned: 183
Modelled: 183
Confidence: 99.8%
Identity: 13%
PDB header:endocytosis/exocytosis, membrane protein
Chain: A: PDB Molecule:bridging integrator 1;
PDBTitle: the crystal structure of the bar domain from human bin1/amphiphysin ii2 and its implications for molecular recognition

Phyre2

PDB 1uru chain A

3D model

Region: 256 - 455
Aligned: 200
Modelled: 199
Confidence: 99.8%
Identity: 20%
PDB header:endocytosis
Chain: A: PDB Molecule:amphiphysin;
PDBTitle: amphiphysin bar domain from drosophila

Phyre2

PDB 1uru chain A

3D model

Region: 256 - 455
Aligned: 200
Modelled: 199
Confidence: 99.8%
Identity: 20%
Fold: BAR/IMD domain-like
Superfamily: BAR/IMD domain-like
Family: BAR domain

Phyre2

PDB 3sog chain A

3D model

Region: 266 - 450
Aligned: 185
Modelled: 185
Confidence: 99.7%
Identity: 15%
PDB header:structural protein
Chain: A: PDB Molecule:amphiphysin;
PDBTitle: crystal structure of the bar domain of human amphiphysin, isoform 1

Phyre2
1
c2dx1A_
2
c3ky9B_
3
c2vrwB_
4
c3odoA_
5
c1xcgA_
6
c4gouA_
7
d1xcga1
8
c1x86A_
9
c3ksyA_
10
c3jv3A_
11
c1foeA_
12
c3t06E_
13
c2dfkA_
14
d1txda1
15
c3bjiA_
16
d2dfka1
17
c2z0qA_
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c1xdvB_
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c4gyvA_
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c1ki1B_
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c2lqnA_
40
c1griA_
41
c2eyzA_
42
c2l3sA_
43
c1ng2A_
44
c1ov3A_
45
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c4avmA_
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c2ficA_
48
c1uruA_
49
d1urua_
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c3sogA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2dx1A_
100.0 26 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
2c3ky9B_
100.0 28 PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1
3c2vrwB_
100.0 27 PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor
4c3odoA_
100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef
5c1xcgA_
100.0 24 PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef
6c4gouA_
100.0 20 PDB header:signaling protein
Chain: A: PDB Molecule:ehrgs-rhogef;
PDBTitle: crystal structure of an rgs-rhogef from entamoeba histolytica
7d1xcga1
100.0 24 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
8c1x86A_
100.0 22 PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa
9c3ksyA_
100.0 21 PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)
10c3jv3A_
100.0 24 PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: structure of sh3e-dh unit of murine intersectin-1l
11c1foeA_
100.0 23 PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1
12c3t06E_
100.0 24 PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa
13c2dfkA_
100.0 26 PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex
14d1txda1
100.0 21 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
15c3bjiA_
100.0 27 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1
16d2dfka1
100.0 27 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
17c2z0qA_
100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)
18c1xdvB_
100.0 20 PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.
19c4gyvA_
100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 2;
PDBTitle: crystal strucure of the dh domain of farp2
20c1ki1B_
100.0 25 PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42
21d1dbha1
not modelled 100.0 21 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
22d1foea1
not modelled 100.0 26 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
23c2rgnB_
not modelled 100.0 21 PDB header:signaling protein complex
Chain: B: PDB Molecule:rhoa/rac/cdc42 exchange factor;
PDBTitle: crystal structure of p63rhogef complex with galpha-q and rhoa
24c4gzuB_
not modelled 100.0 24 PDB header:signaling protein
Chain: B: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 2;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp2
25c3eo2A_
not modelled 100.0 26 PDB header:splicing
Chain: A: PDB Molecule:neuroepithelial cell-transforming gene 1 protein;
PDBTitle: crystal structure of the rhogef domain of human neuroepithelial cell-2 transforming gene 1 protein
26c1lb1C_
not modelled 100.0 28 PDB header:signaling protein
Chain: C: PDB Molecule:guanine nucleotide exchange factor dbs;
PDBTitle: crystal structure of the dbl and pleckstrin homology2 domains of dbs in complex with rhoa
27d1ki1b1
not modelled 100.0 23 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
28c4h6yA_
not modelled 100.0 18 PDB header:signaling protein
Chain: A: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 1;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp1
29d1by1a_
not modelled 100.0 23 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
30c3mpxA_
not modelled 100.0 21 PDB header:lipid binding protein
Chain: A: PDB Molecule:fyve, rhogef and ph domain-containing protein 5;
PDBTitle: crystal structure of the dh and ph-1 domains of human fgd5
31d1f5xa_
not modelled 100.0 25 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
32c3odwB_
not modelled 100.0 23 PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef
33c1dbhA_
not modelled 100.0 18 PDB header:gene regulation
Chain: A: PDB Molecule:protein (human sos 1);
PDBTitle: dbl and pleckstrin homology domains from hsos1
34c3odxA_
not modelled 100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef
35d1kz7a1
not modelled 100.0 28 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
36c1ntyA_
not modelled 100.0 22 PDB header:signaling protein
Chain: A: PDB Molecule:triple functional domain protein;
PDBTitle: crystal structure of the first dh/ph domain of trio to 1.7 a
37d1ntya1
not modelled 100.0 22 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
38c3gf9A_
not modelled 100.0 28 PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 rhogef domain
39c2lqnA_
99.9 17 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
40c1griA_
99.9 18 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
41c2eyzA_
99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
42c2l3sA_
99.9 21 PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk
43c1ng2A_
99.9 23 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox
44c1ov3A_
99.9 22 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex
45c1mv3A_
not modelled 99.9 15 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc
46c4avmA_
99.9 15 PDB header:protein binding
Chain: A: PDB Molecule:bridging integrator 2;
PDBTitle: crystal structure of the n-bar domain of human bridging2 integrator 2.
47c2ficA_
99.8 13 PDB header:endocytosis/exocytosis, membrane protein
Chain: A: PDB Molecule:bridging integrator 1;
PDBTitle: the crystal structure of the bar domain from human bin1/amphiphysin ii2 and its implications for molecular recognition
48c1uruA_
99.8 20 PDB header:endocytosis
Chain: A: PDB Molecule:amphiphysin;
PDBTitle: amphiphysin bar domain from drosophila
49d1urua_
99.8 20 Fold:BAR/IMD domain-like
Superfamily:BAR/IMD domain-like
Family:BAR domain
50c2e5kA_
not modelled 99.8 14 PDB header:protein binding
Chain: A: PDB Molecule:suppressor of t-cell receptor signaling 1;
PDBTitle: solution structure of sh3 domain in suppressor of t-cell2 receptor signaling 1
51d1ng2a2
not modelled 99.8 19 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
52d1udla_
not modelled 99.8 33 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
53c3sogA_
99.7 15 PDB header:structural protein
Chain: A: PDB Molecule:amphiphysin;
PDBTitle: crystal structure of the bar domain of human amphiphysin, isoform 1
54c2ed0A_
not modelled 99.7 22 PDB header:signaling protein
Chain: A: PDB Molecule:abl interactor 2;
PDBTitle: solution structure of the sh3 domain of abl interactor 22 (abelson interactor 2)
55c2dlpA_
not modelled 99.7 19 PDB header:structural protein
Chain: A: PDB Molecule:kiaa1783 protein;
PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein
56c2rqrA_
not modelled 99.7 20 PDB header:protein binding
Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator
PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex
57c2eyyA_
not modelled 99.7 12 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
58c2csqA_
not modelled 99.7 16 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:rim binding protein 2;
PDBTitle: solution structure of the second sh3 domain of human rim-2 binding protein 2
59d1uhca_
not modelled 99.7 42 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
60c2jxbA_
not modelled 99.7 20 PDB header:signaling protein complex
Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain,
PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex
61c2dl7A_
not modelled 99.7 24 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:kiaa0769 protein;
PDBTitle: solution structure of the second sh3 domain of human2 kiaa0769 protein
62c2cudA_
not modelled 99.7 14 PDB header:signaling protein
Chain: A: PDB Molecule:src-like-adapter;
PDBTitle: solution structure of the sh3 domain of the human src-like2 adopter protein (slap)
63c3nmzD_
not modelled 99.7 17 PDB header:cell adhesion/cell cycle
Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crytal structure of apc complexed with asef
64d1ug1a_
not modelled 99.7 24 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
65c1x6gA_
not modelled 99.7 24 PDB header:signaling protein
Chain: A: PDB Molecule:megakaryocyte-associated tyrosine-protein kinase;
PDBTitle: solution structures of the sh3 domain of human2 megakaryocyte-associated tyrosine-protein kinase.
66c4glmD_
not modelled 99.7 28 PDB header:signaling protein
Chain: D: PDB Molecule:dynamin-binding protein;
PDBTitle: crystal structure of the sh3 domain of dnmbp protein [homo sapiens]
67c2oi3A_
not modelled 99.7 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: nmr structure analysis of the hematopoetic cell kinase sh32 domain complexed with an artificial high affinity ligand3 (pd1)
68d1ov3a2
not modelled 99.7 21 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
69c2dnuA_
not modelled 99.7 19 PDB header:structural genomics, structural protein
Chain: A: PDB Molecule:sh3 multiple domains 1;
PDBTitle: solution structure of rsgi ruh-061, a sh3 domain from human
70c2nwmA_
not modelled 99.7 32 PDB header:cell adhesion
Chain: A: PDB Molecule:vinexin;
PDBTitle: solution structure of the first sh3 domain of human vinexin2 and its interaction with the peptides from vinculin
71c2egeA_
not modelled 99.7 22 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein kiaa1666;
PDBTitle: solution structure of the third sh3 domain from human2 kiaa1666 protein
72d1ycsb2
not modelled 99.7 29 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
73d1i1ja_
not modelled 99.7 21 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
74c2yt6A_
not modelled 99.7 26 PDB header:cell cycle
Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full-
PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1
75c2ekhA_
not modelled 99.7 22 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a;
PDBTitle: solution structures of the sh3 domain of human kiaa0418
76c2kbtA_
not modelled 99.7 32 PDB header:signaling protein
Chain: A: PDB Molecule:chimera of proto-oncogene vav, linker,
PDBTitle: attachment of an nmr-invisible solubility enhancement tag2 (inset) using a sortase-mediated protein ligation method
77c2cubA_
not modelled 99.7 21 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck1
78c2df6A_
not modelled 99.7 28 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 7;
PDBTitle: crystal structure of the sh3 domain of betapix in complex2 with a high affinity peptide from pak2
79c2dilA_
not modelled 99.7 30 PDB header:cell adhesion
Chain: A: PDB Molecule:proline-serine-threonine phosphatase-interacting
PDBTitle: solution structure of the sh3 domain of the human proline-2 serine-threonine phosphatase-interacting protein 1
80c2yuoA_
not modelled 99.7 21 PDB header:signaling protein
Chain: A: PDB Molecule:run and tbc1 domain containing 3;
PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3
81c1zlmA_
not modelled 99.7 28 PDB header:signaling protein
Chain: A: PDB Molecule:osteoclast stimulating factor 1;
PDBTitle: crystal structure of the sh3 domain of human osteoclast2 stimulating factor
82c2djqA_
not modelled 99.7 17 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:sh3 domain containing ring finger 2;
PDBTitle: the solution structure of the first sh3 domain of mouse sh32 domain containing ring finger 2
83c1x2qA_
not modelled 99.7 22 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 2;
PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2
84c2dmoA_
not modelled 99.7 29 PDB header:signaling protein
Chain: A: PDB Molecule:neutrophil cytosol factor 2;
PDBTitle: refined solution structure of the 1st sh3 domain from human2 neutrophil cytosol factor 2 (ncf-2)
85c1x6bA_
not modelled 99.7 22 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine exchange factor (gef) 16;
PDBTitle: solution structures of the sh3 domain of human rho guanine2 exchange factor (gef) 16
86c2kymA_
not modelled 99.7 24 PDB header:signaling protein
Chain: A: PDB Molecule:bud emergence protein 1;
PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide
87c2epdA_
not modelled 99.7 23 PDB header:protein binding
Chain: A: PDB Molecule:rho gtpase-activating protein 4;
PDBTitle: solution structure of sh3 domain in rho-gtpase-activating2 protein 4
88d2v1ra1
not modelled 99.7 30 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
89c2dl4A_
not modelled 99.7 28 PDB header:signaling protein
Chain: A: PDB Molecule:protein stac;
PDBTitle: solution structure of the first sh3 domain of stac protein
90d1u5sa1
not modelled 99.7 28 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
91c2dbkA_
not modelled 99.7 17 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structures of the sh3 domain of human crk-like2 protein
92c2csiA_
not modelled 99.7 32 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:rim binding protein 2;
PDBTitle: solution structure of the third sh3 domain of human rim-2 binding protein 2
93c2yupA_
not modelled 99.6 20 PDB header:cell adhesion
Chain: A: PDB Molecule:vinexin;
PDBTitle: solution structure of the second sh3 domain of human vinexin
94c2egaA_
not modelled 99.6 29 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a;
PDBTitle: solution structure of the first sh3 domain from human2 kiaa0418 protein
95d1gcqa_
not modelled 99.6 26 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
96d1gbra_
not modelled 99.6 28 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
97c1x2pA_
not modelled 99.6 25 PDB header:transferase
Chain: A: PDB Molecule:protein arginine n-methyltransferase 2;
PDBTitle: solution structure of the sh3 domain of the protein2 arginine n-methyltransferase 2
98c3qwxX_
not modelled 99.6 25 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
99c2ebpA_
not modelled 99.6 16 PDB header:cell adhesion
Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1;
PDBTitle: solution structure of the sh3 domain from human sam and sh32 domain containing protein 1
100c2l0aA_
not modelled 99.6 32 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 1;
PDBTitle: solution nmr structure of signal transducing adapter molecule 1 stam-12 from homo sapiens, northeast structural genomics consortium target3 hr4479e
101c2ed1A_
not modelled 99.6 20 PDB header:signaling protein
Chain: A: PDB Molecule:130 kda phosphatidylinositol 4,5-biphosphate-
PDBTitle: solution structure of the sh3 domain of 130 kda2 phosphatidylinositol 4,5-biphosphate-dependent arf1 gtpase-3 activating protein
102c1x43A_
not modelled 99.6 21 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:sh3 domain grb2-like protein b1;
PDBTitle: solution structure of the sh3 domain of endophilin b12 (sh3g1b1)
103c2xmfA_
not modelled 99.6 25 PDB header:motor protein
Chain: A: PDB Molecule:myosin 1e sh3;
PDBTitle: myosin 1e sh3
104d1wiea_
not modelled 99.6 25 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
105c2yunA_
not modelled 99.6 29 PDB header:protein transport
Chain: A: PDB Molecule:nostrin;
PDBTitle: solution structure of the sh3 domain of human nostrin
106c1wyxA_
not modelled 99.6 36 PDB header:cell adhesion
Chain: A: PDB Molecule:crk-associated substrate;
PDBTitle: the crystal structure of the p130cas sh3 domain at 1.1 a2 resolution
107c2ysqA_
not modelled 99.6 21 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 9;
PDBTitle: solution structure of the sh3 domain from rho guanine2 nucleotide exchange factor 9
108d1oeba_
not modelled 99.6 28 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
109c1bb9A_
not modelled 99.6 28 PDB header:transferase
Chain: A: PDB Molecule:amphiphysin 2;
PDBTitle: crystal structure of the sh3 domain from rat amphiphysin 2
110d1bb9a_
not modelled 99.6 28 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
111c3qwyA_
not modelled 99.6 27 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
112c2dvjA_
not modelled 99.6 14 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
113d1utia_
not modelled 99.6 29 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
114c2dl8A_
not modelled 99.6 20 PDB header:signaling protein
Chain: A: PDB Molecule:slit-robo rho gtpase-activating protein 2;
PDBTitle: solution structure of the sh3 domain of human slit-robo rho2 gtpase-activating protein 2
115d1oota_
not modelled 99.6 29 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
116d1wlpb2
not modelled 99.6 20 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
117d1nega_
not modelled 99.6 27 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
118c1negA_
not modelled 99.6 27 PDB header:structural protein
Chain: A: PDB Molecule:spectrin alpha chain, brain;
PDBTitle: crystal structure analysis of n-and c-terminal labeled sh3-2 domain of alpha-chicken spectrin
119d1uuea_
not modelled 99.6 29 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
120d1u06a1
not modelled 99.6 29 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain

Binding site prediction 

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