Phyre 2 Results for Q99M51

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Email | l.a.kelley@imperial.ac.uk
Description | Q99M51
Date | Tue Jul 30 13:14:31 BST 2013
Unique Job ID | f11c4db5197c08fc
Sequence | MAEEVVVVAK ... Download FASTA

Summary |

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å): | X:56.286 Y:53.786 Z:29.373
| Close Jmol

Model (left) based on template c1k9aB_
Top template information
PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
Confidence and coverage
Confidence: | 100.0% | Coverage: | 44%
167 residues ( 44% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
358 residues ( 95%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | A | E | E | V | V | V | V | A | K | F | D | Y | V | A | Q | Q | E | Q | E | L | D | I | K | K | N | E | R | L | W | L | L | D | D | S | K | S | W | W | R | V | R | N | S | M | N | K | T | G | F | V | P | S | N | Y | V | E | R | K | N
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | S | A | R | K | A | S | I | V | K | N | L | K | D | T | L | G | I | G | K | V | K | R | K | P | S | V | P | D | T | A | S | P | A | D | D | S | F | V | D | P | G | E | R | L | Y | D | L | N | M | P | A | F | V | K | F | N | Y | M | A | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | R | E | D | E | L | S | L | I | K | G | T | K | V | I | V | M | E | K | C | S | D | G | W | W | R | G | S | Y | N | G | Q | I | G | W | F | P | S | N | Y | V | T | E | E | G | D | S | P | L | G | D | H | V | G | S | L | S | E | K | L | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | A | V | V | N | N | L | N | T | G | Q | V | L | H | V | V | Q | A | L | Y | P | F | S | S | S | N | D | E | E | L | N | F | E | K | G | D | V | M | D | V | I | E | K | P | E | N | D | P | E | W | W | K | C | R | K | I | N | G | M | V | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  | ? |  | ? | ? | ? | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300
Sequence |  | L | V | P | K | N | Y | V | T | I | M | Q | N | N | P | L | T | S | G | L | E | P | S | P | P | Q | C | D | Y | I | R | P | S | L | T | G | K | F | A | G | N | P | W | Y | Y | G | K | V | T | R | H | Q | A | E | M | A | L | N | E | R | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  | ? |  |  | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360
Sequence |  | H | E | G | D | F | L | I | R | D | S | E | S | S | P | N | D | F | S | V | S | L | K | A | Q | G | K | N | K | H | F | K | V | Q | L | K | E | T | V | Y | C | I | G | Q | R | K | F | S | T | M | E | E | L | V | E | H | Y | K | K | A | P
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | .
Sequence |  | I | F | T | S | E | Q | G | E | K | L | Y | L | V | K | H | L | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)
? | Disordered ( 33%)
| Alpha helix ( 7%)
| Beta strand ( 31%)

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c1k9aB_ |

### PDB 1k9a chain B

Region: 186 - 377
Aligned: 167
Modelled: 169
Confidence: 100.0%
Identity: 31%
PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution

Phyre2
2 |
| c2fo0A_ |

### PDB 2fo0 chain A

Region: 179 - 377
Aligned: 167
Modelled: 175
Confidence: 100.0%
Identity: 31%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2
3 |
| c1oplA_ |

### PDB 1opl chain A

Region: 193 - 377
Aligned: 153
Modelled: 161
Confidence: 100.0%
Identity: 34%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase

Phyre2
4 |
| c1y57A_ |

### PDB 1y57 chain A

Region: 191 - 377
Aligned: 156
Modelled: 158
Confidence: 100.0%
Identity: 31%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor

Phyre2
5 |
| c2ablA_ |

### PDB 2abl chain A

Region: 187 - 376
Aligned: 158
Modelled: 166
Confidence: 100.0%
Identity: 33%
PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase

Phyre2
6 |
| c3nhnA_ |

### PDB 3nhn chain A

Region: 193 - 375
Aligned: 152
Modelled: 159
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region

Phyre2
7 |
| c2h8hA_ |

### PDB 2h8h chain A

Region: 194 - 375
Aligned: 151
Modelled: 158
Confidence: 100.0%
Identity: 32%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor

Phyre2
8 |
| c2c0iA_ |

### PDB 2c0i chain A

Region: 194 - 377
Aligned: 152
Modelled: 160
Confidence: 100.0%
Identity: 39%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983

Phyre2
9 |
| c1x27F_ |

### PDB 1x27 chain F

Region: 193 - 375
Aligned: 152
Modelled: 159
Confidence: 100.0%
Identity: 35%
PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas

Phyre2
10 |
| c1griA_ |

### PDB 1gri chain A

Region: 5 - 254
Aligned: 211
Modelled: 225
Confidence: 100.0%
Identity: 25%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2
11 |
| c1g83A_ |

### PDB 1g83 chain A

Region: 193 - 375
Aligned: 153
Modelled: 159
Confidence: 100.0%
Identity: 33%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2

Phyre2
12 |
| c2lqnA_ |

### PDB 2lqn chain A

Region: 2 - 258
Aligned: 179
Modelled: 182
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2
13 |
| c2l3sA_ |

### PDB 2l3s chain A

Region: 6 - 165
Aligned: 160
Modelled: 160
Confidence: 100.0%
Identity: 22%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2
14 |
| c2b3oA_ |

### PDB 2b3o chain A

Region: 193 - 376
Aligned: 179
Modelled: 184
Confidence: 100.0%
Identity: 23%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2
15 |
| c2eyzA_ |

### PDB 2eyz chain A

Region: 2 - 173
Aligned: 172
Modelled: 172
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2
16 |
| c2ci8A_ |

### PDB 2ci8 chain A

Region: 281 - 377
Aligned: 97
Modelled: 97
Confidence: 100.0%
Identity: 100%
PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed

Phyre2
17 |
| c3ps5A_ |

### PDB 3ps5 chain A

Region: 193 - 377
Aligned: 180
Modelled: 185
Confidence: 100.0%
Identity: 24%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2
18 |
| c2shpA_ |

### PDB 2shp chain A

Region: 193 - 376
Aligned: 164
Modelled: 165
Confidence: 100.0%
Identity: 26%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2
19 |
| c2eo6A_ |

### PDB 2eo6 chain A

Region: 235 - 377
Aligned: 119
Modelled: 119
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk

Phyre2
20 |
| c1ng2A_ |

### PDB 1ng2 chain A

Region: 6 - 193
Aligned: 154
Modelled: 154
Confidence: 100.0%
Identity: 23%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c1k9aB_ |
|  | 100.0 | 31 | PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
2 | c2fo0A_ |
|  | 100.0 | 31 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
3 | c1oplA_ |
|  | 100.0 | 34 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
4 | c1y57A_ |
|  | 100.0 | 31 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
5 | c2ablA_ |
|  | 100.0 | 33 | PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
6 | c3nhnA_ |
|  | 100.0 | 37 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
7 | c2h8hA_ |
|  | 100.0 | 32 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor
8 | c2c0iA_ |
|  | 100.0 | 39 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983
9 | c1x27F_ |
|  | 100.0 | 35 | PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
10 | c1griA_ |
|  | 100.0 | 25 | PDB header:signal transduction adaptor Chain: A: PDB Molecule:growth factor bound protein 2; PDBTitle: grb2
11 | c1g83A_ |
|  | 100.0 | 33 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2
12 | c2lqnA_ |
|  | 100.0 | 21 | PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl
13 | c2l3sA_ |
|  | 100.0 | 22 | PDB header:structural protein Chain: A: PDB Molecule:autoinhibited crk protein; PDBTitle: structure of the autoinhibited crk
14 | c2b3oA_ |
|  | 100.0 | 23 | PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1
15 | c2eyzA_ |
|  | 100.0 | 23 | PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii
16 | c2ci8A_ |
|  | 100.0 | 100 | PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
17 | c3ps5A_ |
|  | 100.0 | 24 | PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
18 | c2shpA_ |
|  | 100.0 | 26 | PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2
19 | c2eo6A_ |
|  | 100.0 | 23 | PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
20 | c1ng2A_ |
|  | 100.0 | 23 | PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosolic factor 1; PDBTitle: structure of autoinhibited p47phox
21 | c2eo3A_ |
| not modelled | 100.0 | 27 | PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
22 | d2shpa2 |
| not modelled | 100.0 | 32 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
23 | c1x6cA_ |
| not modelled | 99.9 | 35 | PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
24 | d1mila_ |
| not modelled | 99.9 | 26 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
25 | c2gsbA_ |
| not modelled | 99.9 | 24 | PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
26 | c2eobA_ |
| not modelled | 99.9 | 27 | PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
27 | d3c7ia1 |
| not modelled | 99.9 | 35 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
28 | c3hizB_ |
| not modelled | 99.9 | 26 | PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
29 | c2hdxB_ |
| not modelled | 99.9 | 26 | PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
30 | d1ayaa_ |
| not modelled | 99.9 | 33 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
31 | c3gqiB_ |
| not modelled | 99.9 | 31 | PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
32 | c2kk6A_ |
| not modelled | 99.9 | 25 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
33 | d2oq1a1 |
| not modelled | 99.9 | 30 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
34 | d1fhsa_ |
| not modelled | 99.9 | 35 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
35 | c2dlzA_ |
| not modelled | 99.9 | 28 | PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2
36 | c1ov3A_ |
| not modelled | 99.9 | 27 | PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosol factor 1; PDBTitle: structure of the p22phox-p47phox complex
37 | c2dlyA_ |
| not modelled | 99.9 | 30 | PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
38 | c2vifA_ |
| not modelled | 99.9 | 25 | PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
39 | c2oq1A_ |
| not modelled | 99.9 | 29 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
40 | c2crhA_ |
| not modelled | 99.9 | 26 | PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
41 | c2dcrA_ |
| not modelled | 99.9 | 21 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
42 | d2izva2 |
| not modelled | 99.9 | 27 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
43 | d1a81e1 |
| not modelled | 99.9 | 24 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
44 | d1jyra_ |
| not modelled | 99.9 | 36 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
45 | d2shpa3 |
| not modelled | 99.9 | 38 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
46 | c2y3aB_ |
| not modelled | 99.9 | 28 | PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
47 | c2el8A_ |
| not modelled | 99.9 | 22 | PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain
48 | c2c9wA_ |
| not modelled | 99.9 | 30 | PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
49 | d1nrva_ |
| not modelled | 99.9 | 26 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
50 | c1ka6A_ |
| not modelled | 99.9 | 26 | PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py
51 | d1a81a1 |
| not modelled | 99.9 | 24 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
52 | d1rjaa_ |
| not modelled | 99.9 | 26 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
53 | d1pica_ |
| not modelled | 99.9 | 25 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
54 | d1jwoa_ |
| not modelled | 99.9 | 25 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
55 | d2oq1a2 |
| not modelled | 99.9 | 27 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
56 | d1a81e2 |
| not modelled | 99.9 | 28 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
57 | c2ysxA_ |
| not modelled | 99.9 | 27 | PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain
58 | d1i3za_ |
| not modelled | 99.9 | 30 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
59 | d1qada_ |
| not modelled | 99.9 | 26 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
60 | c2lctA_ |
| not modelled | 99.9 | 27 | PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
61 | c2izvA_ |
| not modelled | 99.9 | 27 | PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
62 | d1d4ta_ |
| not modelled | 99.9 | 26 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
63 | d1fu6a_ |
| not modelled | 99.9 | 22 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
64 | d1r1qa_ |
| not modelled | 99.9 | 34 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
65 | c4fl2A_ |
| not modelled | 99.9 | 25 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch
66 | d1k9aa2 |
| not modelled | 99.9 | 32 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
67 | c2ozoA_ |
| not modelled | 99.9 | 30 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70
68 | d2fcia1 |
| not modelled | 99.9 | 31 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
69 | c2ekxA_ |
| not modelled | 99.9 | 25 | PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain
70 | d2eyva1 |
| not modelled | 99.9 | 29 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
71 | d1a81a2 |
| not modelled | 99.9 | 29 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
72 | d1lkka_ |
| not modelled | 99.9 | 32 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
73 | c2ge9A_ |
| not modelled | 99.9 | 31 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
74 | d1g83a2 |
| not modelled | 99.9 | 35 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
75 | c2hmhA_ |
| not modelled | 99.9 | 27 | PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
76 | d1opka2 |
| not modelled | 99.9 | 32 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
77 | c1a81E_ |
| not modelled | 99.9 | 18 | PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
78 | d1blja_ |
| not modelled | 99.9 | 31 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
79 | c2augB_ |
| not modelled | 99.9 | 28 | PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain
80 | d1xa6a2 |
| not modelled | 99.9 | 19 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
81 | d1csya_ |
| not modelled | 99.9 | 28 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
82 | c3mazA_ |
| not modelled | 99.9 | 20 | PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
83 | d1rpya_ |
| not modelled | 99.9 | 26 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
84 | d1o48a_ |
| not modelled | 99.9 | 28 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
85 | c1rqqC_ |
| not modelled | 99.9 | 25 | PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
86 | d2c9wa2 |
| not modelled | 99.9 | 26 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
87 | d1luia_ |
| not modelled | 99.9 | 24 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
88 | d2qmsa1 |
| not modelled | 99.9 | 25 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
89 | d1bkla_ |
| not modelled | 99.9 | 32 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
90 | d1f2fa_ |
| not modelled | 99.9 | 32 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
91 | c2cr4A_ |
| not modelled | 99.9 | 23 | PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
92 | d2cs0a1 |
| not modelled | 99.9 | 30 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
93 | d1qcfa2 |
| not modelled | 99.9 | 34 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
94 | c2knoA_ |
| not modelled | 99.9 | 28 | PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
95 | c2dm0A_ |
| not modelled | 99.9 | 21 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
96 | d1cwea_ |
| not modelled | 99.9 | 36 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
97 | c2dvjA_ |
| not modelled | 99.8 | 26 | PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii
98 | c1mv3A_ |
| not modelled | 99.8 | 25 | PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:myc box dependent interacting protein 1; PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc
99 | c3qwxX_ |
| not modelled | 99.8 | 27 | PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174
100 | c3qwyA_ |
| not modelled | 99.8 | 25 | PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2
101 | c3gxxB_ |
| not modelled | 99.8 | 23 | PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
102 | c2jw4A_ |
| not modelled | 99.8 | 93 | PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: nmr solution structure of the n-terminal sh3 domain of2 human nckalpha
103 | c2yt6A_ |
| not modelled | 99.8 | 29 | PDB header:cell cycle Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full- PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1
104 | c2eyyA_ |
| not modelled | 99.8 | 29 | PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i
105 | d1ng2a2 |
| not modelled | 99.8 | 17 | Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain
106 | c2jxbA_ |
| not modelled | 99.8 | 81 | PDB header:signaling protein complex Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain, PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex
107 | c2dybA_ |
| not modelled | 99.8 | 15 | PDB header:oxidoreductase Chain: A: PDB Molecule:neutrophil cytosol factor 4; PDBTitle: the crystal structure of human p40(phox)
108 | c2rqrA_ |
| not modelled | 99.8 | 15 | PDB header:protein binding Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex
109 | c2csqA_ |
| not modelled | 99.8 | 20 | PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:rim binding protein 2; PDBTitle: solution structure of the second sh3 domain of human rim-2 binding protein 2
110 | c2dlpA_ |
| not modelled | 99.8 | 13 | PDB header:structural protein Chain: A: PDB Molecule:kiaa1783 protein; PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein
111 | c2cubA_ |
| not modelled | 99.7 | 22 | PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck1
112 | c2k2mA_ |
| not modelled | 99.7 | 31 | PDB header:signaling protein Chain: A: PDB Molecule:eps8-like protein 1; PDBTitle: structural basis of pxxdy motif recognition in sh3 binding
113 | c2yuoA_ |
| not modelled | 99.7 | 16 | PDB header:signaling protein Chain: A: PDB Molecule:run and tbc1 domain containing 3; PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3
114 | c2egeA_ |
| not modelled | 99.7 | 16 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein kiaa1666; PDBTitle: solution structure of the third sh3 domain from human2 kiaa1666 protein
115 | c3or8A_ |
| not modelled | 99.7 | 23 | PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
116 | c2cudA_ |
| not modelled | 99.7 | 19 | PDB header:signaling protein Chain: A: PDB Molecule:src-like-adapter; PDBTitle: solution structure of the sh3 domain of the human src-like2 adopter protein (slap)
117 | c2xp1A_ |
| not modelled | 99.7 | 20 | PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
118 | c2dx0B_ |
| not modelled | 99.7 | 27 | PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
119 | c1wxtA_ |
| not modelled | 99.7 | 30 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein flj21522; PDBTitle: solution structure of the sh3 domain of human hypothetical2 protein flj21522
120 | d1uffa_ |
| not modelled | 99.7 | 19 | Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain

Binding site prediction |

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