Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionA1A535
DateWed Jul 10 14:03:03 BST 2013
Unique Job ID671d1baf5f3b7c66
SequenceMHQLFRLVLG ... Download FASTA

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:41.104 Y:45.645 Z:39.662
Model (left) based on template c2lulA_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase tec;
PDBTitle: solution nmr structure of ph domain of tyrosine-protein kinase tec2 from homo sapiens, northeast structural genomics consortium (nesg)3 target hr3504c
Confidence and coverage
Confidence: 99.3% Coverage: 14%
114 residues ( 14% of your sequence) have been modelled with 99.3% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
450 residues ( 54%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MHQLFRLVLGQKDLSKAGDLFSLDDAEIEDSLTEALEQIKVISSSLDYQTNNNDQAVVEI
Secondary structure 
















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Disorder  ??










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   .........70.........80.........90.........100.........110.........120
Sequence  CITRITTAIRETESIEKHARALVGLWDSCLEHNLRPAGKDEDTPHAKIASDIMSCILQNY
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??

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   .........130.........140.........150.........160.........170.........180
Sequence  NRTPVMVLAVPIAVKFLHRGSKELCRNMSNYLSLAAITKADLLADHTEGIIKSILQGNAM
Secondary structure 







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   .........190.........200.........210.........220.........230.........240
Sequence  LLRVLPAVYEKQPQPINRHLAELLALMSQLEQTEQYHLLRLLHVAAKRKDVEVVQKCVPF
Secondary structure 





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???
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   .........250.........260.........270.........280.........290.........300
Sequence  LIRNLKDSTYNDIILNILIEIAGHEPLALNSFLPMLKEIAEQFPYLTGQMARIFGAVGHV
Secondary structure 







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??
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   .........310.........320.........330.........340.........350.........360
Sequence  DEERARSCLRYLVSQLANMEHPFHHILLLEIKSITDAFSSILGPHSRDIFRMSNSFTNIA
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Disorder  ??














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   .........370.........380.........390.........400.........410.........420
Sequence  KLLSRQLENSKADSSRRKTSTEVSIPEKLRELNSMEPESEDHEKLQVKIQAFEDKINAES
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Disorder  ?????????????????????????????????????????????????????
??????
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   .........430.........440.........450.........460.........470.........480
Sequence  NTPGSGRRYSLDHISKEERKSIRFSRSRSLALNTVLTNGVSVEDNEVEEKAGMHASISLS
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Disorder  ????????????????????????????????????????????????????????????
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   .........490.........500.........510.........520.........530.........540
Sequence  QIDPLSHGIGKLPFKTDTHESPLRNSSASHPSIIHIEPETMPETFKENIQEEILEAATSP
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Disorder  ???????????????????????????????????????????????????
????????
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   .........550.........560.........570.........580.........590.........600
Sequence  VEYQDKLYLHLRENLSKVKAYALEIAKKVPIPDQCTIEDTMRSCVAKLFFTCSLKGHYCL
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Disorder  ???????
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??





?


??
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   .........610.........620.........630.........640.........650.........660
Sequence  YSKSSFILVSQAPQPWIQVMFLSQQSLFPEPLSIQSGSVQFLKALWEKTQDTGAHSFEVA
Secondary structure 




















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Disorder 







?
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???
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   .........670.........680.........690.........700.........710.........720
Sequence  MTESTFPQQKDLEQLQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIE
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   .........730.........740.........750.........760.........770.........780
Sequence  GKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDPPIELSKVQSVKAVAKKRR
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?????
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??????
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   .........790.........800.........810.........820.........830...
Sequence  DRSLPRAFEIFTDSKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTTYL
Secondary structure 

















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??????????????
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Confidence Key
High(9)                    Low (0)
?Disordered ( 44%)
Alpha helix ( 52%)
Beta strand ( 8%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2lul chain A

3D model

Region: 714 - 827
Aligned: 114
Modelled: 114
Confidence: 99.3%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase tec;
PDBTitle: solution nmr structure of ph domain of tyrosine-protein kinase tec2 from homo sapiens, northeast structural genomics consortium (nesg)3 target hr3504c

Phyre2

PDB 2dtc chain B

3D model

Region: 717 - 822
Aligned: 104
Modelled: 106
Confidence: 99.3%
Identity: 23%
PDB header:protein binding
Chain: B: PDB Molecule:ral guanine nucleotide exchange factor ralgps1a;
PDBTitle: crystal structure of ms0666

Phyre2

PDB 1bak chain A

3D model

Region: 717 - 830
Aligned: 105
Modelled: 114
Confidence: 99.2%
Identity: 13%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 2bcj chain A domain 2

3D model

Region: 717 - 823
Aligned: 97
Modelled: 107
Confidence: 99.2%
Identity: 19%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 1btk chain A

3D model

Region: 716 - 821
Aligned: 106
Modelled: 106
Confidence: 99.2%
Identity: 18%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 1x1f chain A domain 1

3D model

Region: 713 - 821
Aligned: 102
Modelled: 109
Confidence: 99.2%
Identity: 18%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 2q13 chain A

3D model

Region: 715 - 817
Aligned: 95
Modelled: 103
Confidence: 99.1%
Identity: 22%
PDB header:protein transport
Chain: A: PDB Molecule:dcc-interacting protein 13 alpha;
PDBTitle: crystal structure of bar-ph domain of appl1

Phyre2

PDB 2dhk chain A

3D model

Region: 713 - 830
Aligned: 112
Modelled: 118
Confidence: 99.1%
Identity: 20%
PDB header:immune system
Chain: A: PDB Molecule:tbc1 domain family member 2;
PDBTitle: solution structure of the ph domain of tbc1 domain family2 member 2 protein from human

Phyre2

PDB 2d9x chain A

3D model

Region: 710 - 831
Aligned: 116
Modelled: 122
Confidence: 99.1%
Identity: 14%
PDB header:lipid transport
Chain: A: PDB Molecule:oxysterol binding protein-related protein 11;
PDBTitle: solution structure of the ph domain of oxysterol binding2 protein-related protein 11 from human

Phyre2

PDB 1u5f chain A domain 1

3D model

Region: 713 - 818
Aligned: 104
Modelled: 106
Confidence: 99.0%
Identity: 24%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 3cxb chain B

3D model

Region: 720 - 820
Aligned: 98
Modelled: 101
Confidence: 99.0%
Identity: 20%
PDB header:signaling protein
Chain: B: PDB Molecule:pleckstrin homology domain-containing family m
PDBTitle: crystal structure of sifa and skip

Phyre2

PDB 2d9w chain A

3D model

Region: 714 - 821
Aligned: 106
Modelled: 108
Confidence: 98.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:docking protein 2;
PDBTitle: solution structure of the ph domain of docking protein 22 from human

Phyre2

PDB 1u5d chain A domain 1

3D model

Region: 718 - 820
Aligned: 102
Modelled: 103
Confidence: 98.9%
Identity: 18%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 3a8q chain B

3D model

Region: 720 - 831
Aligned: 105
Modelled: 112
Confidence: 98.9%
Identity: 28%
PDB header:signaling protein
Chain: B: PDB Molecule:t-lymphoma invasion and metastasis-inducing
PDBTitle: low-resolution crystal structure of the tiam2 phccex domain

Phyre2

PDB 2kcj chain A

3D model

Region: 717 - 823
Aligned: 99
Modelled: 107
Confidence: 98.9%
Identity: 18%
PDB header:membrane protein
Chain: A: PDB Molecule:pleckstrin homology domain-containing family a
PDBTitle: solution structure of fapp1 ph domain

Phyre2

PDB 2yry chain A

3D model

Region: 712 - 818
Aligned: 102
Modelled: 107
Confidence: 98.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:pleckstrin homology domain-containing family a
PDBTitle: solution structure of the ph domain of pleckstrin homology2 domain-containing family a member 6 from human

Phyre2

PDB 4h8s chain A

3D model

Region: 702 - 817
Aligned: 109
Modelled: 116
Confidence: 98.9%
Identity: 24%
PDB header:signaling protein
Chain: A: PDB Molecule:dcc-interacting protein 13-beta;
PDBTitle: crystal structure of human appl2barph domain

Phyre2

PDB 3nsu chain A

3D model

Region: 717 - 815
Aligned: 95
Modelled: 99
Confidence: 98.9%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:phosphatidylinositol 4,5-bisphosphate-binding protein slm1;
PDBTitle: a systematic screen for protein-lipid interactions in saccharomyces2 cerevisiae

Phyre2

PDB 2d9z chain A

3D model

Region: 713 - 821
Aligned: 102
Modelled: 109
Confidence: 98.8%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:protein kinase c, nu type;
PDBTitle: solution structure of the ph domain of protein kinase c, nu2 type from human

Phyre2

PDB 1u5f chain A

3D model

Region: 701 - 818
Aligned: 112
Modelled: 118
Confidence: 98.8%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:src-associated adaptor protein;
PDBTitle: crystal structure of the ph domain of skap-hom with 8 vector-derived2 n-terminal residues

Phyre2

PDB 1w63 chain A

3D model

Region: 51 - 339
Aligned: 261
Modelled: 261
Confidence: 97.8%
Identity: 11%
PDB header:endocytosis
Chain: A: PDB Molecule:adapter-related protein complex 1 gamma 1
PDBTitle: ap1 clathrin adaptor core

Phyre2

PDB 1gw5 chain B

3D model

Region: 32 - 340
Aligned: 285
Modelled: 285
Confidence: 97.6%
Identity: 14%
Fold: alpha-alpha superhelix
Superfamily: ARM repeat
Family: Clathrin adaptor core protein

Phyre2

PDB 2db0 chain B

3D model

Region: 127 - 336
Aligned: 208
Modelled: 208
Confidence: 97.4%
Identity: 12%
PDB header:protein binding
Chain: B: PDB Molecule:253aa long hypothetical protein;
PDBTitle: crystal structure of ph0542

Phyre2

PDB 2jkr chain L

3D model

Region: 53 - 340
Aligned: 276
Modelled: 276
Confidence: 97.0%
Identity: 12%
PDB header:endocytosis
Chain: L: PDB Molecule:ap-2 complex subunit alpha-2;
PDBTitle: ap2 clathrin adaptor core with dileucine peptide rm(2 phosphos)qikrllse

Phyre2

PDB 2lg1 chain A

3D model

Region: 687 - 826
Aligned: 134
Modelled: 134
Confidence: 97.0%
Identity: 16%
PDB header:metal binding protein
Chain: A: PDB Molecule:a-kinase anchor protein 13;
PDBTitle: solution structure of the human akap13 ph domain and stabilizing dh2 helix

Phyre2

PDB 2fug chain A

3D model

Region: 612 - 746
Aligned: 126
Modelled: 126
Confidence: 81.0%
Identity: 20%
PDB header:oxidoreductase
Chain: A: PDB Molecule:nadh-quinone oxidoreductase chain 1;
PDBTitle: crystal structure of the hydrophilic domain of respiratory complex i2 from thermus thermophilus

Phyre2
1

c2lulA_
2

c2dtcB_
3

d1baka_
4

d2bcja2
5

d1btka_
6

d1x1fa1
7

c2q13A_
8

c2dhkA_
9

c2d9xA_
10

d1u5fa1
11

c3cxbB_
12

c2d9wA_
13

d1u5da1
14

c3a8qB_
15

c2kcjA_
16

c2yryA_
17

c4h8sA_
18

c3nsuA_
19

c2d9zA_
20

c1u5fA_
21



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c1w63A_
84

d1gw5b_
85



86



87

c2db0B_
88



89



90



91

c2jkrL_
92

c2lg1A_
93



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96



97



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c2fugA_
135



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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2lulA_



99.3 18 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase tec;
PDBTitle: solution nmr structure of ph domain of tyrosine-protein kinase tec2 from homo sapiens, northeast structural genomics consortium (nesg)3 target hr3504c
2c2dtcB_



99.3 23 PDB header:protein binding
Chain: B: PDB Molecule:ral guanine nucleotide exchange factor ralgps1a;
PDBTitle: crystal structure of ms0666
3d1baka_



99.2 13 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
4d2bcja2



99.2 19 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
5d1btka_



99.2 18 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
6d1x1fa1



99.2 18 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
7c2q13A_



99.1 22 PDB header:protein transport
Chain: A: PDB Molecule:dcc-interacting protein 13 alpha;
PDBTitle: crystal structure of bar-ph domain of appl1
8c2dhkA_



99.1 20 PDB header:immune system
Chain: A: PDB Molecule:tbc1 domain family member 2;
PDBTitle: solution structure of the ph domain of tbc1 domain family2 member 2 protein from human
9c2d9xA_



99.1 14 PDB header:lipid transport
Chain: A: PDB Molecule:oxysterol binding protein-related protein 11;
PDBTitle: solution structure of the ph domain of oxysterol binding2 protein-related protein 11 from human
10d1u5fa1



99.0 24 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
11c3cxbB_



99.0 20 PDB header:signaling protein
Chain: B: PDB Molecule:pleckstrin homology domain-containing family m
PDBTitle: crystal structure of sifa and skip
12c2d9wA_



98.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:docking protein 2;
PDBTitle: solution structure of the ph domain of docking protein 22 from human
13d1u5da1



98.9 18 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
14c3a8qB_



98.9 28 PDB header:signaling protein
Chain: B: PDB Molecule:t-lymphoma invasion and metastasis-inducing
PDBTitle: low-resolution crystal structure of the tiam2 phccex domain
15c2kcjA_



98.9 18 PDB header:membrane protein
Chain: A: PDB Molecule:pleckstrin homology domain-containing family a
PDBTitle: solution structure of fapp1 ph domain
16c2yryA_



98.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:pleckstrin homology domain-containing family a
PDBTitle: solution structure of the ph domain of pleckstrin homology2 domain-containing family a member 6 from human
17c4h8sA_



98.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:dcc-interacting protein 13-beta;
PDBTitle: crystal structure of human appl2barph domain
18c3nsuA_



98.9 20 PDB header:signaling protein
Chain: A: PDB Molecule:phosphatidylinositol 4,5-bisphosphate-binding protein slm1;
PDBTitle: a systematic screen for protein-lipid interactions in saccharomyces2 cerevisiae
19c2d9zA_



98.8 22 PDB header:signaling protein
Chain: A: PDB Molecule:protein kinase c, nu type;
PDBTitle: solution structure of the ph domain of protein kinase c, nu2 type from human
20c1u5fA_



98.8 22 PDB header:signaling protein
Chain: A: PDB Molecule:src-associated adaptor protein;
PDBTitle: crystal structure of the ph domain of skap-hom with 8 vector-derived2 n-terminal residues
21d1wgqa_



not modelled 98.8 16 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
22c2dn6A_



not modelled 98.8 24 PDB header:signaling protein
Chain: A: PDB Molecule:kiaa0640 protein;
PDBTitle: solution structure of the ph domain of kiaa0640 protein2 from human
23d1wi1a_



not modelled 98.8 20 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
24d1v5ua_



not modelled 98.8 24 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
25c2rloA_



not modelled 98.8 19 PDB header:signaling protein
Chain: A: PDB Molecule:centaurin-gamma 1;
PDBTitle: split ph domain of pi3-kinase enhancer
26d1v5pa_



not modelled 98.8 25 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
27d1w1ha_



not modelled 98.8 20 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
28d1unqa_



not modelled 98.8 24 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
29c3tfmA_



not modelled 98.7 17 PDB header:motor protein
Chain: A: PDB Molecule:myosin x;
PDBTitle: myosin x ph1n-ph2-ph1c tandem
30c2da0A_



not modelled 98.7 19 PDB header:signaling protein
Chain: A: PDB Molecule:130-kda phosphatidylinositol 4,5-biphosphate-
PDBTitle: solution structure of the ph domain of pip2-dependent arf12 gtpase-activating protein from human
31c2rsgA_



not modelled 98.7 19 PDB header:lipid transport
Chain: A: PDB Molecule:collagen type iv alpha-3-binding protein;
PDBTitle: solution structure of the cert ph domain
32c2dkpA_



not modelled 98.7 21 PDB header:signaling protein
Chain: A: PDB Molecule:pleckstrin homology domain-containing family a
PDBTitle: solution structure of the ph domain of pleckstrin homology2 domain-containing protein family a member 5 from human
33c2lkoA_



not modelled 98.7 14 PDB header:cell adhesion
Chain: A: PDB Molecule:fermitin family homolog 2;
PDBTitle: structural basis of phosphoinositide binding to kindlin-2 pleckstrin2 homology domain in regulating integrin activation
34c2r09A_



not modelled 98.7 21 PDB header:signaling protein
Chain: A: PDB Molecule:cytohesin-3;
PDBTitle: crystal structure of autoinhibited form of grp1 arf gtpase exchange2 factor
35d1wjma_



not modelled 98.7 29 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
36d1v88a_



not modelled 98.7 17 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
37d2coaa1



not modelled 98.7 23 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
38c3a8nA_



not modelled 98.7 27 PDB header:signaling protein
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis-inducing
PDBTitle: crystal structure of the tiam1 phccex domain
39c2j59O_



not modelled 98.7 22 PDB header:hydrolase
Chain: O: PDB Molecule:rho-gtpase activating protein 10;
PDBTitle: crystal structure of the arf1:arhgap21-arfbd complex
40d1eaza_



not modelled 98.7 25 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
41d1plsa_



not modelled 98.7 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
42d2elba2



not modelled 98.7 23 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
43d2i5fa1



not modelled 98.6 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
44c3pp2A_



not modelled 98.6 24 PDB header:hydrolase activator
Chain: A: PDB Molecule:rho gtpase-activating protein 27;
PDBTitle: crystal structure of the pleckstrin homology domain of arhgap27
45d1u5ea1



not modelled 98.6 24 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
46d1wg7a_



not modelled 98.6 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
47d1p6sa_



not modelled 98.6 23 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
48d2j59m1



not modelled 98.6 27 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
49c2ys3A_



not modelled 98.6 16 PDB header:signaling protein
Chain: A: PDB Molecule:unc-112-related protein 2;
PDBTitle: solution structure of the ph domain of kindlin-3 from human
50d2fjla1



not modelled 98.6 15 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
51c2rovA_



not modelled 98.6 19 PDB header:transferase
Chain: A: PDB Molecule:rho-associated protein kinase 2;
PDBTitle: the split ph domain of rock ii
52d1upqa_



not modelled 98.5 22 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
53d2coca1



not modelled 98.5 16 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
54d2coda1



not modelled 98.5 17 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
55c4f7hA_



not modelled 98.5 17 PDB header:cell adhesion
Chain: A: PDB Molecule:fermitin family homolog 2;
PDBTitle: the crystal structure of kindlin-2 pleckstrin homology domain in free2 form
56c1faoA_



not modelled 98.5 26 PDB header:signaling protein
Chain: A: PDB Molecule:dual adaptor of phosphotyrosine and 3-
PDBTitle: structure of the pleckstrin homology domain from2 dapp1/phish in complex with inositol 1,3,4,5-3 tetrakisphosphate
57d1faoa_



not modelled 98.5 26 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
58c4bbkA_



not modelled 98.5 17 PDB header:cell adhesion
Chain: A: PDB Molecule:fermitin family homolog 1;
PDBTitle: structural and functional characterisation of the kindlin-12 pleckstrin homology domain
59c4gzuB_



not modelled 98.5 23 PDB header:signaling protein
Chain: B: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 2;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp2
60c3fehA_



not modelled 98.4 19 PDB header:hydrolase activator
Chain: A: PDB Molecule:centaurin-alpha-1;
PDBTitle: crystal structure of full length centaurin alpha-1
61c2p0fA_



not modelled 98.4 20 PDB header:ligand binding protein
Chain: A: PDB Molecule:rho gtpase-activating protein 9;
PDBTitle: arhgap9 ph domain in complex with ins(1,3,5)p3
62d1fgya_



not modelled 98.4 22 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
63d1v89a_



not modelled 98.4 25 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
64c2d9vA_



not modelled 98.4 14 PDB header:membrane protein
Chain: A: PDB Molecule:pleckstrin homology domain-containing protein
PDBTitle: solution structure of the ph domain of pleckstrin homology2 domain-containing protein family b member 1 from mouse
65d1qqga1



not modelled 98.4 18 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
66c2dhiA_



not modelled 98.4 17 PDB header:signaling protein
Chain: A: PDB Molecule:pleckstrin homology domain-containing family b
PDBTitle: solution structure of the ph domain of evectin-2 from mouse
67d1u29a1



not modelled 98.4 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
68d1btna_



not modelled 98.3 23 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
69d1x1ga1



not modelled 98.3 18 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
70c2y7bA_



not modelled 98.3 19 PDB header:cell cycle
Chain: A: PDB Molecule:actin-binding protein anillin;
PDBTitle: crystal structure of the ph domain of human actin-binding2 protein anillin anln
71c1qqgA_



not modelled 98.2 20 PDB header:signal transduction
Chain: A: PDB Molecule:insulin receptor substrate 1;
PDBTitle: crystal structure of the ph-ptb targeting region of irs-1
72d1droa_



not modelled 98.2 17 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
73c3hk0B_



not modelled 98.2 21 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 10;
PDBTitle: crystal structure of the ra and ph domains of grb10
74d2cofa1



not modelled 98.2 19 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
75c4gmvB_



not modelled 98.2 23 PDB header:cell adhesion
Chain: B: PDB Molecule:ras-associated and pleckstrin homology domains-containing
PDBTitle: crystal structure of the coiled-coil, ra and ph domains of2 lamellipodin
76d1ki1b2



not modelled 98.2 23 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
77d2dyna_



not modelled 98.1 18 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
78c2k2jA_



not modelled 98.1 21 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: nmr solution structure of the split ph domain from2 phospholipase c gamma 2
79c3o96A_



not modelled 98.1 23 PDB header:transferase
Chain: A: PDB Molecule:rac-alpha serine/threonine-protein kinase;
PDBTitle: crystal structure of human akt1 with an allosteric inhibitor
80d1xx0a1



not modelled 98.1 24 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
81c3tcaA_



not modelled 98.0 19 PDB header:signaling protein
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member
PDBTitle: crystal structure of the ras-associating and pleckstrin-homology2 domains of riam
82c4h6yA_



not modelled 97.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 1;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp1
83c1w63A_



97.8 11 PDB header:endocytosis
Chain: A: PDB Molecule:adapter-related protein complex 1 gamma 1
PDBTitle: ap1 clathrin adaptor core
84d1gw5b_



97.6 14 Fold:alpha-alpha superhelix
Superfamily:ARM repeat
Family:Clathrin adaptor core protein
85c3ml4D_



not modelled 97.5 19 PDB header:signaling protein
Chain: D: PDB Molecule:protein dok-7;
PDBTitle: crystal structure of a complex between dok7 ph-ptb and the musk2 juxtamembrane region
86d2dfka2



not modelled 97.4 18 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
87c2db0B_



97.4 12 PDB header:protein binding
Chain: B: PDB Molecule:253aa long hypothetical protein;
PDBTitle: crystal structure of ph0542
88d1rj2a2



not modelled 97.3 17 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
89d1maia_



not modelled 97.3 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
90d1v61a_



not modelled 97.2 17 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
91c2jkrL_



97.0 12 PDB header:endocytosis
Chain: L: PDB Molecule:ap-2 complex subunit alpha-2;
PDBTitle: ap2 clathrin adaptor core with dileucine peptide rm(2 phosphos)qikrllse
92c2lg1A_



97.0 16 PDB header:metal binding protein
Chain: A: PDB Molecule:a-kinase anchor protein 13;
PDBTitle: solution structure of the human akap13 ph domain and stabilizing dh2 helix
93d1ntya2



not modelled 96.5 16 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
94d1zc3b1



not modelled 96.4 16 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
95d1xcga2



not modelled 96.4 23 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
96c3odwB_



not modelled 96.3 13 PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef
97c3mpxA_



not modelled 96.3 21 PDB header:lipid binding protein
Chain: A: PDB Molecule:fyve, rhogef and ph domain-containing protein 5;
PDBTitle: crystal structure of the dh and ph-1 domains of human fgd5
98c3bjiA_



not modelled 96.2 19 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1
99c3ky9B_



not modelled 96.1 23 PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1
100c2vszA_



not modelled 96.0 23 PDB header:apoptosis
Chain: A: PDB Molecule:engulfment and cell motility protein 1;
PDBTitle: crystal structure of the elmo1 ph domain
101c3qwmA_



not modelled 95.9 15 PDB header:signaling protein
Chain: A: PDB Molecule:iq motif and sec7 domain-containing protein 1;
PDBTitle: crystal structure of gep100, the plextrin homology domain of iq motif2 and sec7 domain-containing protein 1 isoform a
102c2vrwB_



not modelled 95.9 23 PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor
103d1dbha2



not modelled 95.6 27 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
104d1kz7a2



not modelled 95.5 20 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
105c1x86A_



not modelled 95.1 18 PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa
106c2dfkA_



not modelled 95.0 19 PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex
107c3w3zA_



not modelled 95.0 13 PDB header:protein transport/nuclear protein
Chain: A: PDB Molecule:importin subunit beta-3;
PDBTitle: crystal structure of kap121p bound to rangtp
108c3odxA_



not modelled 95.0 14 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef
109c3a98B_



not modelled 94.7 23 PDB header:signaling protein
Chain: B: PDB Molecule:engulfment and cell motility protein 1;
PDBTitle: crystal structure of the complex of the interacting regions of dock22 and elmo1
110c1ki1B_



not modelled 94.3 19 PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42
111c1xcgA_



not modelled 94.2 19 PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef
112d1txda2



not modelled 93.5 22 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
113c3v6aA_



not modelled 92.0 20 PDB header:apoptosis inhibitor
Chain: A: PDB Molecule:apoptosis inhibitor 5;
PDBTitle: helical repeat structure of apoptosis inhibitor 5 reveals protein-2 protein interaction modules
114c3ohmB_



not modelled 91.5 15 PDB header:signaling protein / hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3
115d1omwa2



not modelled 91.3 20 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
116c2nppE_



not modelled 89.6 18 PDB header:hydrolase/hydrolase inhibitor
Chain: E: PDB Molecule:serine/threonine-protein phosphatase 2a 56 kda regulatory
PDBTitle: structure of the protein phosphatase 2a holoenzyme
117d2nppb1



not modelled 89.6 18 Fold:alpha-alpha superhelix
Superfamily:ARM repeat
Family:B56-like
118d2bpta1



not modelled 89.5 7 Fold:alpha-alpha superhelix
Superfamily:ARM repeat
Family:Armadillo repeat
119c2rgnB_



not modelled 88.8 16 PDB header:signaling protein complex
Chain: B: PDB Molecule:rhoa/rac/cdc42 exchange factor;
PDBTitle: crystal structure of p63rhogef complex with galpha-q and rhoa
120c3qr0A_



not modelled 88.7 16 PDB header:hydrolase
Chain: A: PDB Molecule:phospholipase c-beta (plc-beta);
PDBTitle: crystal structure of s. officinalis plc21

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