I have just moved the entire Phyre system to a much larger computing farm which should speed things up considerably for users. In addition, there have been some fold library changes and sequence database changes. If you have any problems with the new system please let me know as soon as possible. There are bound to be some teething problems at the beginning.

Also I would like to offer my sincere thanks for the large number of glowing letters of support we received for our grant proposal to continue to develop the Phyre server. The grant is now in the hands of the funding body and it will be quite some time (possbly 6 months) before we hear whether we have been successful or not. Once again I would like to express my gratitude to those who took the time to write a letter.

Lawrence Kelley

Repeated hardware problems have delayed the intended updates to Phyre.

However, I have decided to list some of the most common requests I have had from users, so at least I can remember what they were.

Some news at last! I finally have the time to do a bit of work on the server. Over the next few days I intend to install a new fold library and get the fully automated fold library updates in place. Because this will involve some code alterations, I will have to take Phyre down for a few days. After that *hopefully* we will have fully automated updates.

After that, I will hopefully get a few variants of Phyre in an advanced options page, one of them mimicking very closely the behaviour of 3D-PSSM. So those of you who still like the old school methods will be able to use them.

Thanks for using Phyre!