Over the past few years we have collected information on the preparation and characterisation of HEAVY-ATOM derivatives of protein crystals. This information has been assembled in the form of a DATABANK (called HAD). In addition to the experimental information this databank also contains information resulting from an analysis of the binding of these heavy-atoms with proteins in the crystal environment. In summary, the databank contains the following information:

  • Experimental Conditions for crystallisation
  • Chemical details of the heavy-atom compounds used
  • Bibliographic References
  • Atomic coordinates of heavy-atoms
  • Details of binding sites of heavy-atoms/protein crystal environment
  • Atomic coordinates of heavy-atoms/protein crystal environment
  • This databank will be of interest, not only to protein crystallographers but to anyone interested in the interaction of heavy-atoms with proteins. We would like to thank the many Crystallographers who kindly provided information which was not available in the literature.

    Please send all comments/queries to Suhail A. Islam


    David Carvin, Suhail A Islam, Michael JE Sternberg and Thomas L Blundell
    Establishment of a Heavy-Atom Databank for Protein Structures Isomorphous Replacement and Anomalous Scattering.
    Proceedings of CCP4 Study Weekend - 25-26 January 1991 Science and Engineering Research Council, Daresbury Laboratory

    David Carvin, Suhail A Islam, Michael JE Sternberg and Thomas L Blundell
    HAD, A Databank of Heavy-Atom binding sites in protein crystals: A resource for use in multiple isomorphous replacement and anomalous scattering.
    Acta. Cryst., Sect. D-Biological Crystallography. Nov 1 1998; 54 Part 6 Special Iss. S1: 1199-1206

    Carivn, D, Islam, S.A., Sternberg, S and Blundell, T.L.
    The preparation of heavy-atom derivatives of protein crystals for use in multiple isomorphous replacement
    International Tables for Crystallography, Volume F Chapter 12.1.